KR102659842B1 - Health functional food composition for improvement of bowel function and relief of contipation comprising psyllium husk and complex extract, and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a health functional food composition containing psyllium husk and complex extract for improving intestinal function and promoting bowel movements, and a method for producing the same. Since it can improve symptoms related to bowel function and defecation, such as a feeling of residual stool and abdominal distension, it can be usefully used to improve bowel function and promote defecation.

Description

Health functional food composition for improving intestinal function and promoting bowel movements containing psyllium husk and complex extract, and method for manufacturing the same

The present invention relates to a health functional food composition containing psyllium husk and complex extract for improving intestinal function and promoting bowel movements, and a method for producing the same.

Modern people's physical activity level has decreased due to longer working hours, developed means of transportation, and improved living standards, while their eating habits have become westernized and instantaneous, increasing their intake of calories and decreasing their intake of fiber. As a result, metabolic diseases, which were common in the West, are gradually increasing in Korea, and in particular, the number of people with constipation, which is well known in clinical practice, is increasing.

In general, it is normal for 12-72 hours after ingestion of food to be excreted to the outside. However, for some reason, there are cases where it cannot be discharged outside the human body and stays in the intestines for a long time, which is called constipation.

Constipation is more of a symptom than a disease, and appears as a variety of symptoms and illnesses. The most common symptoms include a decrease in the number of bowel movements (e.g., less than 3 times a week), irregular bowel movements, painful or difficult bowel movements, hard and dry bowel movements, a feeling of residual stool, and abnormally small amounts of bowel movements (e.g., bowel movements per day). 50 g or less) is common.

Medically, constipation is defined as having a bowel movement less than once every 3-4 days, emphasizing the number of bowel movements or difficulty in having a bowel movement. Constipation is known to be more common in women than men and in older patients than young people.

Constipation may result from intestinal obstruction or flow obstruction, anal and pelvic abnormalities, neurological disorders, metabolic or hormonal abnormalities, drug side effects, and dehydration or immobilization. Constipation can occur for no specific reason (chronic constipation), lack of exercise, neglect of bowel movements, low fiber intake, irregular lifestyle habits (e.g. long distance travel or hospital stay), or personal factors (Bosaeus, 2004).

Conventionally, various defecation-promoting medicines, functional foods, etc. have been used to improve or treat constipation, but in most cases, their effects are minimal or temporary, so it is difficult to say that they can fundamentally treat constipation.

Therefore, there is a need to develop functional food compositions for improving intestinal function and promoting bowel movements using natural ingredients that are harmless to the human body.

Republic of Korea Patent Publication No. 10-1450968

Recognizing the problems of the prior art, the present inventors have discovered that when taking a health functional food composition containing a specific extract, symptoms related to bowel function and defecation, such as bowel movement frequency, bowel movement hardness, bowel pain, gas generation, residual stool sensation, and abdominal distension, are reduced. It was demonstrated that it has an improving effect and can be usefully used to improve intestinal function and promote defecation, and the present invention was completed.

The present invention relates to psyllium husk; and complex extracts of kelp, Houttuynia cordata, turmeric root, Cornus officinalis, licorice and gilgyeong; It relates to a food composition for improving intestinal function and promoting bowel movements, including.

The present invention relates to a method of producing the health functional food composition for improving intestinal function and promoting bowel movements.

This will be explained in detail below. All combinations of the various elements disclosed herein fall within the scope of the present invention. Additionally, the scope of the present invention cannot be considered limited by the specific description below.

The present invention relates to psyllium husk; and complex extracts of kelp, Houttuynia cordata, turmeric root, Cornus officinalis, licorice and gilgyeong; It provides a food composition for improving intestinal function and promoting bowel movements, including.

In the present invention, "Psyllium husk" is obtained from the husk of Psyllium, which is a mature seed of the perennial herb Plantago asiatica belonging to the Plantaginaceae family, by extraction, separation, and purification methods well known in the art. Or it refers to a commercially available reagent in powder form. Psyllium is mainly produced in India, which accounts for about 80% of the world's production, and the husk of psyllium seeds, which weigh less than 2 g per 1,000 psyllium seeds, is called psyllium husk. In oriental medicine, psyllium has been widely used as a powerful diuretic for nephritis, cystitis, and urethritis. It contains a lot of minerals, proteins, vitamins, and polysaccharides, and the components contained in psyllium are known to be involved in anti-inflammatory effects. there is.

In the present invention, "Laminaria japonica" refers to perennial large brown algae belonging to the Laminariaceae family, also referred to as Phaeophyceae kelp, seaweed, or seaweed. In appearance, it is divided into leaves, stems, and roots. It is a tropical seaweed distributed along the coasts of the boreal and subarctic zones. In Korea, it grows wild in the northern part of the east coast and Hamgyeongbuk-do north of Wonsan, and is cultivated in areas such as the southern part of the east coast and Wando in the southern sea bay. The kelp has been widely used for food or medicinal purposes in Korea, Japan, and China since ancient times.

In the present invention, "Houttuynia cortata" is called Houttuynia cortata because it is a herb with the smell of fish since ancient times. Houttuynia cordata is known to be effective in treating skin diseases, has an inhibitory effect on viruses, and has excellent antioxidant effects, so it has anti-inflammatory effects, anti-dementia effects, and is effective in Parkinson's disease. It is also being developed as a cosmetic for improving acne. It has been reported that Houttuynia cordata contains abundant flavonoid components.

In the present invention, "Tungtungmadi" is an annual herbaceous plant belonging to the Mongolia family, has strong salt resistance among halophytes, and is an obligate halophyte that absolutely requires salt for growth. Tungtungmadi contains a large amount of vegetable salts (NaCl, KCl, etc.), calcium, magnesium, potassium, etc. in the body, and is also rich in nutrients such as a large amount of dietary fiber and essential amino acids, and plant physiologically active substances such as chlorophyll, polyphenols, and flavonoids. It has been used as a folk remedy to remove toxins and waste accumulated in the body and to treat cancer, high blood pressure, diabetes, hepatitis, skin diseases, arthritis, etc.

In the present invention, "Cornus officinalis" refers to a deciduous small tree belonging to the Dogwood family grown in Korea and other tropical to temperate regions, and includes various varieties and subspecies. The flesh of Cornus officinalis contains glycosides such as cornin and Morroniside, which excite the parasympathetic nerves, and Loganin, tannin, and saponin, which have a slight central nervous stimulating effect. It contains a large amount of tannin and vitamin A, which are astringent ingredients, and is effective in nourishing and astringent. It also has functional ingredients such as selenium, which can prevent cancer, and also contains vitamin A and a large amount of sugar.

In the present invention, the flesh, leaves, stems, seeds and/or roots of Cornus officinalis may be used, and according to embodiments of the present invention, fruits may be preferably used.

In the present invention, “Licorice” refers to a perennial herb belonging to the legume family distributed in northeastern China, Siberia, Mongolia, and northern China. The roots and lower part of the stem of licorice can be used as a sweetener and as a treatment for stomach ulcers and duodenal ulcers, and because they mellow the action of other medicines, they are also used for various purposes in oriental medicine. In general, licorice contains glycyrrhizin, glabric acid, sucrose, glucose, liquiritin, and lycoricidin, and glycyrrhizin is effective in detoxifying diphtheria toxin, snake venom, and puffer fish venom, so it is also used as a treatment for tetanus.

In the present invention, "Platycodon root", also referred to as bellflower, is a perennial plant of the Campanula family that commonly grows in mountains or fields, has a height of 40 to 100 centimeters, and refers to a plant with thick roots and a single stem. . Gilgyeong has been used as a medicinal herb for neuralgia and tonsillitis, and has expectorant, antitussive, analgesic, sedative, and antipyretic effects, so it is also used as an anti-inflammatory analgesic and antitussive expectorant.

In the present invention, psyllium husk, kelp, Houttuynia cordata, cauliflower, Cornus officinalis, licorice, and apricot root used as raw materials can be used without limitation, whether collected from nature, cultivated directly, or commercially available (including processed ones).

In the present invention, “extract” refers to the result of extraction using an appropriate extraction solvent and extraction method, and the extract refers to the extract obtained through extraction, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, a preparation thereof, or Includes purified products or fractions.

In the present invention, “composite extract” refers to an extract extracted through a certain manufacturing process from a mixture of the raw materials of each extract simultaneously.

According to embodiments of the present invention, the raw materials for producing the complex extract may be kelp, Houttuynia cordata, Tungtung mari, Cornus officinalis, licorice, and Gilger root, which are crushed and evenly mixed.

According to embodiments of the present invention, the complex extract may be extracted from a raw material mixture of kelp, Houttuynia cordata, turmeric root, Cornus officinalis, licorice, and Gilger root in a weight ratio of 1:1:1:1:1:1. , the weight ratio may be intended to demonstrate the excellent effect of the active ingredient of the complex extract.

According to embodiments of the present invention, the health functional food composition may include the psyllium husk and the complex extract in a weight ratio of 1:1, and the weight ratio indicates an excellent effect by the active ingredient of the health functional food composition. It may be for.

In the present invention, “active ingredient” refers to an ingredient that can exhibit the desired activity (effect) alone or in combination with a carrier that is not active on its own, and can be used interchangeably with the active ingredient in the present specification. .

The complex extracts of kelp, Houttuynia cordata, turmeric, Cornus officinalis, licorice, and gilgyeong contained in the health functional food composition of the present invention may be extracted and mixed using a specific manufacturing method to enhance the effect of improving intestinal function and promoting defecation.

In the present invention, the complex extract may be extracted by a method comprising the following steps:

S1) pulverizing a mixture of raw materials of kelp, Houttuynia cordata, cauliflower, cornelian perilla, licorice and gilgyeong, adding 80% (w/v) ethanol to the pulverized raw material mixture, and then homogenizing by stirring;

S2) ultrasonically extracting the homogenized raw material mixture solution by sonicating it at 60 to 80° C. for 2 to 4 hours;

S3) filtering the sonicated solution and separating it into a filtrate and a residue;

S4) adding purified water to the separated residue and homogenizing it by stirring;

S5) heat-treating the homogenized solution at 130 to 150°C for 2 to 4 hours to perform hot water extraction;

S6) filtering the heat-treated solution and separating it into a filtrate and a residue; and

S7) Mixing the filtrate separated in steps S3 and S6.

Hereinafter, each step of the complex extract manufacturing method will be described in detail.

In the complex extract production method of the present invention, step S1 is a step of preparing a raw material mixture solution by pulverizing the raw material mixture, adding a solvent, and then stirring and homogenizing.

In step S1, the solvent is preferably 80% (w/v) ethanol for the ultrasonic extraction to be performed following step S1. If purified water is used, the yield of the active ingredient to be extracted may be low.

In step S1, the raw material mixture may be in a frozen state. That is, in step S1 of the present invention, the raw material mixture may be prepared in a frozen state and pulverized through a grinder.

The pulverization in step S1 may be performed to achieve a size of 10 to 500 ㎛, preferably 400 to 500 ㎛.

If pulverized to a size smaller than the above range, time and energy efficiency may be reduced in the process of pulverizing the frozen raw material mixture, and if pulverized larger than the above range, the active ingredients contained in the raw material mixture may not be sufficiently extracted. Otherwise, the effect intended by the present invention may not be sufficiently achieved.

Additionally, in step S1, the raw material mixture may undergo a pretreatment step including the following steps before grinding:

a) washing and mixing kelp, Houttuynia cordata, cauliflower root, Cornus officinalis, licorice root, and Gilger root, adding purified water, leaving for 10 to 20 minutes, and removing moisture;

b) freezing the dried mixture at -40 to -50°C and leaving it at room temperature for 3 to 4 hours; and

c) Drying the left mixture and then freezing it at -40 to -50°C.

In step a), the cutting may be performed so that the size of the raw material is 0.1 to 1.0 cm, preferably 0.3 to 0.7 cm. According to embodiments of the present invention, cutting may be performed to about 0.5 cm, but is not limited thereto.

Step a) is to immerse (permeate) the purified water into each raw material. It is sufficient to leave the purified water for a time to be sufficiently absorbed into the raw material mixture, but for manufacturing efficiency, it may be preferable to leave it for 10 to 20 minutes. there is.

In step a), “removing water” means removing purified water present outside the mixture. For example, it may be removing the mixture and purified water present outside the mixture by passing it through a filter, but is limited to this. That is not the case. Additionally, it may mean removing 90% to 99.9%, preferably 95% to 99.9%, of purified water present outside the mixture, but is not limited thereto.

Step b) is a step of freezing and thawing the raw material mixture immersed in purified water. According to embodiments of the present invention, step b) is repeated three or more times, and may preferably be performed continuously. , more preferably 3 to 5 times, more preferably 4 or 5 times, and may be performed continuously, but is not limited thereto.

If performed less frequently than the above range, the effect of increasing extraction of active ingredients due to pretreatment may be minimal, and if performed more often than the above range, the effect of increasing extraction of active ingredients relative to time and energy consumption may not be significant. It is not appropriate in terms of manufacturing efficiency.

In the experimental example described later, it was specifically demonstrated that when step b) is repeated three or more times, the effect of improving intestinal function and promoting defecation can be greatly improved, and when a pretreatment step is performed in the production of a complex extract, the active ingredient It was confirmed that the extraction yield could be increased.

In the complex extract manufacturing method of the present invention, step S2 is a step of ultrasonic extraction of the homogenized raw material mixture solution.

The S2 step is performed at 60 to 80°C. If the temperature is below the above temperature range, extraction of the components contained in the raw material mixture may not occur sufficiently, and if it exceeds the above range, the extraction yield may increase and the extraction time may be shortened. , there is a problem that the active ingredients contained in the raw material mixture may be denatured by heat. Therefore, considering both the extraction yield and integrity of the active ingredient, the temperature in the above range is very advantageous.

The step S2 may be performed for 2 to 4 hours, and according to embodiments of the present invention, may be performed for about 3 hours, but is not limited thereto.

If the extraction time is less than the above-mentioned time range, the extraction of the active ingredient contained in the raw material mixture may not occur sufficiently, and if it exceeds the above-mentioned range, the extraction yield of the active ingredient relative to the time may be lowered, which may not be appropriate in terms of manufacturing efficiency.

In addition, when the ultrasonic extractor is irradiated with a focus on a specific location, the temperature of the medium may rise and the active ingredients contained in the raw materials may be destroyed or denatured. Therefore, in step S2, ultrasonic extraction is performed with continuous stirring. The stirring may be performed using a stirring device provided in the ultrasonic irradiation device, or may be performed using a separately provided stirring device.

In the complex extract production method of the present invention, steps S3 and S6 are steps of separating the residue and the filtrate containing the active substance by ultrasonic extraction, and the separation can be performed using a known method.

In the complex extract production method of the present invention, steps S4 and S5 are steps of hot water extraction of the residue remaining after separation in step S3.

In step S5, the solvent is preferably purified water, and when an organic solvent is used, the yield of the active ingredient to be extracted remaining in the residue may be lowered.

Step S5 may be performed at 130 to 150°C and may be performed for 2 to 4 hours.

Below the above temperature range, extraction of the components contained in the residue may not occur sufficiently, and if it exceeds the above range, the extraction yield may increase and the extraction time may be shortened, but the active ingredients contained in the residue may be denatured by heat. There is a problem that could happen. Therefore, considering both the extraction yield and integrity of the active ingredient, the temperature in the above range is very advantageous.

In addition, if the extraction time is less than the above time range, the extraction of the active ingredient contained in the residue may not sufficiently occur, and if it exceeds the above range, the extraction yield of the active ingredient relative to time may be lowered, which may not be appropriate in terms of manufacturing efficiency. there is.

Between steps S2 and S3 in the complex extract production method of the present invention; And it may further include the step of cooling the extract obtained between steps S5 and S6 to 2 to 6°C and leaving it to stand (ripen) for 4 to 6 hours, thereby improving intestinal function and defecation of the extracted active ingredient. It can have the effect of increasing the promotion effect.

In the complex extract manufacturing method of the present invention, step S7 is a step of mixing the filtrate separated in steps S3 and S6, and the maximum amount of components extracted from the raw materials is obtained by a manufacturing method in which each different extraction method is performed continuously and sequentially. This is the mixing step.

In the complex extract production method of the present invention, performing steps S1 to S7 continuously and sequentially may be advantageous for extracting maximum active ingredients from the raw materials. In the experimental examples described below, steps S1 to S7 may be performed continuously and sequentially. It was specifically demonstrated that the effect of improving intestinal function and promoting defecation can be increased.

In the present invention, the composition may further include mixed lactic acid bacteria.

The mixed lactic acid bacteria include Lactobacillus acidophilus, Lactobacillus bifidus, Lactobacillus acidophilus, Streptococcus faecalis, and Streptococcus faecium. , Bacillus subtilis, Bacillus licheniformis, Bacillus polyfermenticus, Bacillus mesentericus, Saccharomyces cerevisiae, It may be one or more selected from the group consisting of Clostridium butyricum, Pediococcus pentosaceus, Enterococcus faecium and Bifidobacterium longum. However, it is not limited to this, and any lactic acid bacteria known to have the effect of improving intestinal function and promoting defecation can be used.

In the present invention, “health functional food” refers to food manufactured using nutrients that are easily deficient in daily diet or raw materials or ingredients with useful functions for the human body, and refers to food that helps maintain the health of the human body, but is limited thereto. It does not mean that it is possible and includes all health foods in the conventional sense.

In the present invention, the health functional food can be commercialized as a health functional food by mixing it with food additives in the form of tablets, capsules, pills, granules, liquid, powder, flakes, syrup, gel, jelly, bars, films, etc.

Food additives that can be mixed into the health functional food include, for example, flavoring agents, sweeteners, flavors, preservatives, natural carbohydrates, nutrients, vitamins, electrolytes, colorants, pextan and its salts, alginic acid and its salts, It may be an organic acid, a protective colloidal thickener, a pH adjuster, a stabilizer, a preservative, glycerin, alcohol, etc., but is not limited thereto, and can be added to food as long as it can have a beneficial effect on the health functional food composition of the present invention. May be included without limitation.

In addition, the health functional food composition of the present invention, in addition to the active ingredients, is already known in the art to be safe in order to improve intestinal function and increase/reinforce the effect of promoting defecation, and to improve the convenience of taking or ingesting through the addition of similar activity. It may further include any compounds or natural extracts that have been verified and known to have the corresponding activity. These compounds or extracts include compounds, extracts, and pharmaceuticals listed in compendial documents such as the Pharmacopoeia of each country (in Korea, the "Korean Pharmacopoeia") and the Code of Health Functional Foods of each country (in Korea, it is the "Standards and Specifications for Health Functional Foods" notified by the Ministry of Food and Drug Safety). The laws of each country that govern the manufacture and sale of compounds, extracts, and health functional foods that have received product approval in accordance with the laws of each country (in Korea, this is the “Pharmaceutical Affairs Act”) (in Korea, this is the “Health Functional Foods Act”) 」) includes compounds or extracts whose functionality has been recognized.

Another aspect of the present invention is psyllium husk; and complex extracts of kelp, Houttuynia cordata, Tungtung cauliflower, Cornus officinalis, licorice and gilgyeong; It provides a method of manufacturing a health functional food for improving bowel function and promoting bowel movements, including.

Unless otherwise stated, the method for producing a health functional food for improving intestinal function and promoting defecation of the present invention is the same as described in the composition for health functional food for improving intestinal function and promoting defecation, and the description is provided to avoid excessive repetition of the specification. Omit it.

The health functional food composition of the present invention can improve bowel function and bowel movement-related phenomena such as bowel movement frequency, bowel movement hardness, bowel pain, gas generation, residual stool sensation, and abdominal distension, and is therefore useful for improving bowel function and promoting bowel movements. You can.

In addition, the health functional food composition for improving intestinal function and promoting bowel movements of the present invention contains active ingredients extracted from various natural raw materials, so that the useful effects of the raw materials can be enjoyed.

In addition, the health functional food composition for improving intestinal function and promoting defecation of the present invention can be taken for a long period of time due to its high preference for taste and aroma, so it can be easily used to achieve the purpose of improving intestinal function and promoting defecation.

Hereinafter, the present invention will be described in more detail by examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited by these examples. Additionally, terms not specifically defined in this specification should be understood to have meanings commonly used in the technical field to which the present invention pertains.

Example

(1) Manufacturing of raw material composite extract

1) Pretreatment stage of raw material mixture

1-1) Clean the kelp, Houttuynia cordata, cauliflower, Cornus officinalis, licorice and gilgyeong (purchased at the herbal medicine market in Dongdaemun-gu or online open market) thoroughly, then cut them into pieces of about 0.5 cm and grind them 1:1:1:1:1: It was mixed evenly at a weight ratio of 1. Afterwards, purified water was added to 300 g of the mixture, left for about 15 minutes to allow the purified water to be absorbed into the raw materials, and the raw material mixture was filtered through a strainer to remove moisture.

1-2) The obtained raw material mixture was frozen at a cryogenic temperature of about -40 to -50°C using a freezer (QF-700), and the frozen raw material mixture was taken out at room temperature and left for about 3 to 4 hours ( thawed), and the above process (freezing and thawing) was repeated three additional times (total of four times).

1-3) The raw material mixture that went through the freezing and thawing steps was dried by hot air drying and then frozen at an ultra-low temperature of about -40 to -50°C to complete the raw material mixture pretreatment step.

2) Manufacturing of raw material composite extract

2-1) Grind 100 g of the pretreated raw material mixture in a frozen state through a grinder to a size of approximately 400 to 500 ㎛, add approximately 10 times the volume of 80% (w/v) ethanol, and homogenize by stirring for 10 minutes. did.

2-2) The homogenized raw material mixture was extracted with continuous stirring for 3 hours using an ultrasonic extractor (Power Sonica, Hwashin Tech) while maintaining the temperature at 60 to 80°C.

Thereafter, the obtained extract was cooled to 4°C, left for about 5 hours, filtered through a filter (6 ㎛) to separate the filtrate and residue, and the filtrate (first extract) was stored separately.

2-3) Add about 10 times the volume of purified water to the separated residue, homogenize it by stirring for 10 minutes, perform hot water extraction at about 130 to 150°C for 3 hours, and cool the obtained extract to 4°C, After leaving for about 5 hours, it was filtered through a filter (6 ㎛) to separate the filtrate and residue, and the filtrate (second extract) was stored separately.

2-4) Afterwards, the first and second extracts were mixed, concentrated under reduced pressure, and freeze-dried (Eyela NE, Tokyo, Japan) to prepare a raw material composite extract.

(2) psyllium husk and manufacturing of pills containing the raw material complex extract.

Psyllium husk (purchased in powder form in the open market) and raw material complex extract are mixed at a weight ratio of 1:1, and through a known pill manufacturing method, 80% by weight of the mixture of psyllium husk and raw material complex extract and 0.4% by weight of magnesium hydroxide based on the total weight of the pill. %, 0.4% by weight of magnesium sulfate, 2.4% by weight of fructooligosaccharide, and 4% by weight of salt were prepared.

Comparative example One

In the pretreatment step of the raw material mixture of the example, a ring containing a mixture of psyllium husk and raw material composite extract was prepared through substantially the same method as the example, except that the freezing and thawing of steps 1-2 were repeated a total of two times. did.

Comparative example 2

In the preparation of the raw material composite extract of the Example, a ring containing a mixture of psyllium husk and the raw material composite extract was prepared through substantially the same method as the Example, except that it was extracted by the method below.

3-1) 100 g of the raw material mixture pretreated in steps 1-1 to 1-3 of the above example was crushed to a size of about 400 to 500 ㎛ through a grinder in a frozen state, and then about 10 times the volume of purified water was added, It was homogenized by stirring for 10 minutes.

3-2) The homogenized raw material mixture was subjected to hot water extraction at about 130 to 150°C for 3 hours, and the obtained extract was cooled to 4°C, left for about 5 hours, and then filtered through a filter (6 ㎛). The liquid and residue were separated, and the filtrate (first' extract) was stored separately.

3-3) Approximately 10 times the volume of 80% (w/v) ethanol was added to the separated residue, then homogenized by stirring for 10 minutes, and the homogenized raw material mixture was maintained at 60 to 80° C. using an ultrasonic extractor. Extraction was performed using (Power Sonica, Hwashin Tech) with continuous stirring for 3 hours.

Afterwards, the obtained extract was 4 After cooling and leaving for about 5 hours, it was filtered through a filter (6 ㎛) to separate the filtrate and residue, and the filtrate (second' composite extract) was stored separately.

3-4) Afterwards, the first' and second' extracts were mixed, concentrated under reduced pressure, and freeze-dried (Eyela NE, Tokyo, Japan) to prepare a raw material composite extract.

Experiment example . Confirmed effect of improving intestinal function and promoting bowel movements

In order to confirm whether the composition of the present invention has excellent intestinal function improvement and defecation promotion effects, the following experiment was performed.

The experimental participants were 40 women in their 20s to 40s who frequently suffer from constipation. They were divided into 4 groups and took 10 g of the pills of Examples and Comparative Examples 1 and 2 with plenty of water every morning and evening for two weeks. The food was to be consumed, and if possible, to be consumed at a certain time.

Additionally, during the experiment period, the subjects were advised not to consume functional products or medicines to improve constipation, and they were advised to eat the same meals as usual.

The evaluation criteria are as follows, and the results are shown in Table 1 as average values.

[Evaluation standard]

1. Defecation frequency (%) - Calculated as the number of successful defecation days during the experiment period

2. Bowel consistency - diarrhea 1 point, loose stool 2 points, normal stool 3 points, hard stool 4 points, small stool 5 points

3. Pain in defecation - none at all 1 point, none at 2 points, moderate 3 points, present 4 points, severe 5 points

4. Gas generation - 1 point for none, 2 points for none, 3 points for moderate, 4 points for presence, 5 points for severe.

5. Feeling of residual stool - not at all 1 point, not at all 2 points, moderate 3 points, slightly present 4 points, severe 5 points

6. Abdominal distension - 1 point for none, 2 points for none, 3 points for moderate, 4 points for presence, 5 points for severe.

Example Comparative Example 1 Comparative Example 2 Control group ^* Defecation frequency (%) 86 50 64 29 Bowel change 2.8 4.1 3.6 4.5 bowel movement pain 1.8 3.6 3.6 4.5 Gas generation 2.3 3.6 3.2 4 A feeling of residual change 1.3 3.6 2.8 4 abdominal distension 1.8 3.9 3.3 4

( ^* Pills provided that do not contain psyllium husk or complex extract)

As can be seen in Table 1, the experimental participants administered the examples showed improvements in bowel movement frequency, bowel movement hardness, bowel movement pain, gas production, residual stool sensation, and abdominal distension compared to the control group.

In addition, in the case of Comparative Example 1 and Comparative Example 2, which had a difference in the manufacturing method in the composite weight, there was an effect of improving defecation frequency, defecation hardness, defecation pain, gas generation, residual stool sensation, and abdominal distension, respectively. Compared to this, the example also showed a significant improvement effect. This confirms that the effects of improving intestinal function and promoting defecation can be significantly increased even by differences in manufacturing methods.

Claims (5)

psyllium husk; and
In a health functional food composition for improving intestinal function and promoting defecation, comprising complex extracts of kelp, Houttuynia cordata, turmeric, Cornus officinalis, licorice and gilgyeong,
The complex extract is,
S1) Washing and mixing kelp, Houttuynia cordata, columbine, Cornus officinalis, licorice and Gilger root, adding purified water and leaving for 10 to 20 minutes, then removing moisture;
S2) Freezing the water-removed mixture at -40 to -50°C and leaving it at room temperature for 3 to 4 hours;
S3) drying the left mixture and freezing it at -40 to -50°C;
S4) pulverizing the frozen raw material mixture, adding 80% (w/v) ethanol to the pulverized raw material mixture, and homogenizing it by stirring;
S5) ultrasonically extracting the homogenized raw material mixture solution by sonicating it at 60 to 80° C. for 2 to 4 hours;
S6) filtering the sonicated solution and separating it into a filtrate and a residue;
S7) adding purified water to the separated residue and homogenizing it by stirring;
S8) hydrothermal extraction of the homogenized solution at 130 to 150°C for 2 to 4 hours;
S9) filtering the heat-treated solution and separating it into a filtrate and a residue; and
S10) mixing the filtrate separated in steps S6 and S9; prepared by a method comprising:
Step S2 is repeated 3 to 5 times,
The S5 step is a health functional food composition for improving intestinal function and promoting bowel movements, which is performed with continuous stirring. According to paragraph 1,
The complex extract is a health functional food for improving intestinal function and promoting bowel movements, which is extracted from a mixture of raw materials made by mixing kelp, Houttuynia cordata, turmeric root, Cornus officinalis, licorice and Gilger root in a weight ratio of 1:1:1:1:1:1. Composition. According to paragraph 1,
A health functional food composition for improving intestinal function and promoting bowel movements, wherein the psyllium husk and complex extract are included in a weight ratio of 1:1. According to paragraph 1,
Between steps S5 and S6; And a health functional food composition for improving intestinal function and promoting defecation, further comprising cooling the extract obtained between steps S8 and S9 to 2 to 6°C and leaving it for 4 to 6 hours. According to paragraph 1,
The composition is a health functional food composition for improving intestinal function and promoting bowel movements, further comprising mixed lactic acid bacteria.