CN104888172B - Treat ginger green onion cough arresting and the application of allergic cough - Google Patents
Treat ginger green onion cough arresting and the application of allergic cough Download PDFInfo
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Abstract
The invention discloses a kind of ginger green onion cough arresting for treating allergic cough and applications, it is characterised in that：It is made of the raw material of following parts by weight：15-20 parts of ginger, 15-20 parts of Bulbus Allii Fistulosi, 10-15 parts of the tuber of pinellia, 10-15 parts of Sweet tea, 30-40 parts of brown sugar.The present invention ginger green onion cough arresting have heat reliving and toxin-eliminating, relieving cough and reducing sputum, warming middle energizer to arrest vomiting, promoting menstruation facilitaing lung, antiallergy, moistening lung effect；Especially for wind-cold affecting lung, Lung Qi obstruction, impairment of dispersing and descending function of the lung is that the allergic cough of main pathogenesis has extraordinary curative effect；And patient take rear adverse reaction it is few, it is easy cure, uneasy to recur, good effect, have no toxic side effect；And prescription is simple, materials are easy, safe and reliable, economic and practical.
Description
Technical field
The present invention relates to Chinese herbal medicine preparation technology fields, and in particular to a kind of ginger green onion cough arresting for treating allergic cough
And application.
Background technology
Allergic cough is chronic cough common in clinical respiratory system, is defined as allergia cough at present, that is, refers to
Clinically certain chronic coughs have the factor of some idiocrasys, and antihistamine and glucocorticoid treatment are effective, but cannot examine
Break as asthma, allergic rhinitis or Eosinophilic bronchitis.In recent years, due to the raising of industrialization degree, environment because
The deterioration of element, the incidence of the disease has the tendency that increasing year by year, few to the document report of allergic cough both at home and abroad, not yet shape
Into unified theoretical system, do not attract people's attention.Doctor trained in Western medicine clinically has certain effect, but have one with antihistamine drug treatment
Fixed adverse reaction, and be easy to recur.Not to the name of disease of allergic cough in traditional Chinese medical science ancient book and records, thus etiology and pathogenesis is discussed
State less, modern Chinese medicine generally believes that the disease is equivalent to " cough " scope of the traditional Chinese medical science, but to still depositing difference on the pathogenesis etiology interpretation of the cause, onset and process of an illness
View.The present inventor is from the symptom analysis of disease, and patient is based on the cough of paroxysmal fierceness, with dry cough with a small amount of white foam
Sample sputum based on dry throat is itched, night or aggravates, the raw meats such as feed, fish, shrimp, egg when lacking clothing to the wind or when meeting other irritative gas
Aggravation during taste, the state of an illness is long, the features such as being mainly in two season of spring in autumn, it is believed that the cause of disease is based on chill, wind-cold affecting lung, lung qi
It does not declare, impairment of dispersing and descending function of the lung is main pathogenesis.
In short, allergic cough is at present still without unified diagnostic criteria, both at home and abroad to the document report of allergic cough
Seldom, unified theoretical system is not yet formed, is not attracted people's attention.Doctor trained in Western medicine with antihistamine and/or glucocorticoid treatment,
Not to the name of disease of allergic cough in traditional Chinese medical science ancient book and records, thus it is less to etiology and pathogenesis discussion, and modern doctor thinks allergy
Property cough should belong to traditional Chinese medicine " cough " scope, the opinion of the disease is controlled and still needs to be inquired into.
Invention content
Itd is proposed the purpose of the present invention is insufficient for the above-mentioned prior art a kind of adverse reaction it is few, it is easy cure, be not easy it is multiple
Hair, good effect, have no toxic side effect；And the treatment allergic cough that prescription is simple, materials are easy, safe and reliable, economic and practical
Ginger green onion cough arresting and application.
Technical scheme is as follows：
The ginger green onion cough arresting of present invention treatment allergic cough, is made of the raw material of following weight ratio：
15-20 parts of ginger, 15-20 parts of Bulbus Allii Fistulosi, 10-15 parts of the tuber of pinellia, 10-15 parts of Sweet tea, 30-40 parts of brown sugar.
The present invention is made of Chinese medicinal materials such as ginger, Bulbus Allii Fistulosi, the tuber of pinellia, Sweet tea, brown sugar, has heat reliving and toxin-eliminating, relieving cough and reducing sputum,
Warming middle energizer to arrest vomiting, promoting menstruation facilitaing lung, antiallergy, moistening lung effect；Especially for wind-cold affecting lung, Lung Qi obstruction, impairment of dispersing and descending function of the lung is
The allergic cough of main pathogenesis has extraordinary curative effect.
Each medicine effective ingredient analysis of the ginger green onion cough arresting Chinese medicine preparation of above-described treatment allergic cough：
Ginger,【Alias】Race, hundred peppery clouds, hook dress refer to, because ground is pungent, hot and cold boy, fresh ginger, honey toast ginger, ginger peel, ginger
Silver, hundred peppery clouds；【Latin】Zingiber officinale Roscoe. ；It is Zingiber herbaceos perennial ginger（Zingiber officinale Roscoe）Fresh rhizome；Flavor efficacy：Pungent, tepor.Can whet the appetite preventing or arresting vomiting, preventing phlegm from forming and stopping coughing,
Inducing sweat and dispelling exogenous evils, warming middle energizer to arrest vomiting, solving toxin of fish and crab, antidote poison.Pharmacological action 1, the effect to digestive system：Ginger be treatment hydrochloric acid-
The active drug of alcohol repellency ulcer, active ingredient are zingiberene, have the function of to protect Gastric Mucosal Cells in fragrant stomach invigorating crude drug
In, it is one of stomach invigorating life the effective elements of the medicine mostly containing terpenes derived essential oils such as zingiberenes particularly in zingiberaceous plant.2nd, to cycle
The effect of system and respiratory system：Ginger alcohol extracting thing has excitation to anesthetized cat vasomotor center and respiratory center, right
Heart also has direct excitation.Normal person's chewing ginger 1g（It does not swallow）, systolic pressure can be made averagely to increase 1.489 kPa
（11.2mmHg）, diastolic pressure rising 1.862kPa（14mmHg）, pulse frequency is then had no significant effect.3rd, resisting pathogenic microbes makees
With：Ginger extract has staphylococcus aureus, staphylococcus albus, typhoid bacillus, bacterium sonnei, Pseudomonas aeruginosa
Obvious inhibiting effect, effect are in dependence with concentration.Especially made with the inhibition of staphylococcus aureus and staphylococcus albus
With most by force.4th, other are acted on：Ginger mud and ginger leachate have wound healing apparent facilitation ginger juice liquid energies one
Determine growth of cancer cells is inhibited to add in Ginger P.E in some antitumor drugs in degree that the secondary work of tumour medicine can be mitigated
With.Ginger has nitrosation reaction under the conditions of simulate the gastric juice apparent blocking effect, inhibits the active ingredient of nitrous acid synthesis
To thermostabilization, after heating the long duration in boiling water, still keep quite strongly active.Ginger P.E has antianaphylactic medicine
Effect, can prevent anaphylactic shock, prevent nettle rash caused by certain fish proteins.①《Mingyi Bielu》：Acrid flavour, tepor.It is main
Control cold headache, nasal obstruction, cough with dyspnea, anti-nausea.Also, ginger, tepor is pungent, Gui Wuzang.Go phlegm, lower gas, anti-nausea, except wind
Evil fever and chills.The small will of long term usage lacks intelligence, sad gas.②《Bencao Shiyi》：Outside this work(, juice antidote from remaining blood-breaking, tune, goes cold, removes
Phlegm, appetizing.It hot must remove the peel, cold and stay skin.③《Drug property cerse》：Acrid flavour, it is warm-natured, it is nontoxic.It rises, sun.It is with having four：System
The tuber of pinellia has the work(of removing toxic substances, and assistant jujube has saying for thick intestines.Wind of the temperature through scattered table heresy, QI invigorating stop the sound of vomiting that stomach turns over.
Bulbus Allii Fistulosi,【Alias】Shallot, chive, chives, spring onion, four seasons green onion；【Latin】Bulbus Allii Fistulosi.For liliaceous plant green onionAllium fistulosum L.The bulb of nearly root, i.e., at the nearly root of green onion.Color is white, therefore
Claim " Bulbus Allii Fistulosi "；【Nature and flavor】Acrid flavour；It is warm-natured.【Major function】It expels pathogenic wind from the body surface, resolving sputum, disperse accumulation dissipates the stasis of blood.Cure cold chill；Cold sensation of the genitalia abdomen
Bitterly；Constipation and anuresis；Dysentery；Sore, carbuncle and painful swelling；Abdominal pain due to enterositosis.Shallot contains abundant nutritional ingredient, contains according to surveying and determination per hectogram shallot
Protein 1~4 grams weary, 0.3 gram of fat, 6~8.6 grams of carbohydrate, 0.5 gram of crude fibre, 12 milligrams of calcium, 46 milligrams of phosphorus, iron
0.6 milligram, 1.2 milligrams of carrotene, 14 milligrams of ascorbic acid, contained carrotene is higher than melon, legume vegetable.Shallot contains volatilization
The aromatic substances such as the allyl sulfides of property, both green onion can stimulate the secretion of human consumption's liquid, spleen benefiting and stimulating the appetite improves a poor appetite.Eat green onion energy more
Inducing blood cell generates interferon, enhances the immune function of human body, improves disease resistance.Often edible green onion can soften blood vessel,
Dilute blood can not only improve coronary flow cycle, prevent coronary heart disease, and have health care prevention effect to cerebral apoplexy.
①《Detailed outline》：Green onion, the disease controlled, more category too yin, yangs are bright, it is all taken to dissipate the work(of ventilation.Ventilation event can detoxify and regulating blood condition disease.②
《It does not record》：Cure the wound cold bone and flesh pain, and larynx numbness is obstructed, tocolysis. ③《This warp》：Main typhoid fever fever and chills, perspiration apoplexy, appearance swell.
The tuber of pinellia,【Alias】Three do not fall, split knife grass, crotons, numb taro fruit, Thunder God, it is literary, water is beautiful, show aunt, sheep eye partly
Summer and aunt, nilgiri nettle, the pearl tuber of pinellia, the jump of three steps, general stone, francolin, old shaven head, nobuo, day fall star；【Latin】Pinellia ternata (Thunb.) Breit.；It is distributed widely in the areas such as Yangtze River in China basin and northeast, North China.Medicine
With plant, there is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, coma due to blocking of the respiratory system head
Bitterly, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus；Raw controlling outward carbuncle swells subcutaneous nodule.【Nature and flavor】Acrid flavour, it is warm-natured.①《This warp》：" main typhoid fever
Fever and chills, hardness in the epigastrium, lower gas, laryngopharynx swelling and pain, dizzy chest is swollen, and cough is inverse, borborygmus, hidroschesis."②《It does not record》：" the trusted subordinate's chest diaphragm phlegm heat that disappears expires
Knot, cough with dyspnea, acute pain in the epigastrium heavily fortified point ruffian, when gas vomit it is inverse；Impotence Huang is treated in subduing inflammation, induced abortion, pleases pool appearance.Life is made us spitting, ripe to make us
Under." "③《Haigoushen》：" dissolving phlegm saliva, Appetizing spleen-tonifying, anti-nausea, go in the heart phlegm expire, lower lung qi, main cough knot.New survivor rubs painting
Carbuncle swells do not disappear, and can remove knurl goitre.The deficiency of vital energy and have mental disorder, add and use it.".
Sweet tea,【Latin】Rubus Suavissmus S, Lee,It is rose family rubus plant also known as sweet leaf stirrup
Son is perennial wait-a-bit, and the leaves of plants is sweet, therefore named Sweet tea.Sweet tea mainly originates in the ground such as Guilin, Wuzhou, Liuzhou
Area is the distinctive plant in Guangxi.With the Wild sweet tea on the ground such as Jinxiu Yao ethnic group in Guangxi province autonomous county, Guangxi Teng County, Maoershan, Guangxi most
It is good.Sweet tea contains the minerals such as rubusoside, flavones, tea polyphenols, protein, amino acid, vitamin and iron, calcium, zinc, has
Blood vessel is delayed in clearing heat and detoxicating, cancer-resisting antiallergy, moistening lung for removing phlegm cough-relieving, anti-fat lipid-lowering and blood-pressure-lowing, reduction cholesterolemia, inhibition and the court of a feudal ruler
Numerous healthcare functions such as hardening, prevention and treatment of coronary heart disease and diabetes.Pharmacological action：1st, reducing blood lipid, blood glucose, cholesterol, research hair
Existing, certain density rubusoside has apparent effect for reducing blood fat, and rubusoside can also reduce normal mouse blood glucose level, to mouse
Gluconeogenesis significantly inhibits；Meanwhile rubusoside can be substantially reduced serum triglyceride level, to cholesterol level
There is reduction effect.2nd, cough-relieving apophlegmatic, sweet tea extract have inhibiting effect to concentrated ammonia liquor trial cough, can significantly increase respiratory tract
Phenol red discharge rate shows cough-relieving apophlegmatic effect, and with preferable analgesia, anti-inflammatory, sedation.In Japan, Sweet tea has been used as
Antisensitizer.3rd, melanin is decomposed, contained brass substance decomposable asymmetric choice net melanin in Sweet tea, the formation for inhibiting blackspot and chloasma.
In addition, a kind of Sweet tea or nontoxic, high sugariness, the low calorie and natural sweet taste plant with healthcare function, are a kind of ideal
Carbohydrate substitute, to avoiding because eating for long-term excess is sugared, human body is caused to get fat and induce hypertension, diabetes, cardiovascular disease, kidney
The people of the diseases such as dirty have good auxiliary curative effect, are a kind of natural plants of great Development volue.
Brown sugar, refers to the sugarcane commerieal sugar with honey, and sugarcane concentrates the band honey of formation through squeezing the juice.Brown sugar presses crystalline particle not
Together, it is divided into brown granulated sugar, brown sugar powder, bowl sugar etc., because no height of passing through is concise, almost remains whole ingredients in sugarcane juice, remove
Outside the function of having sugar, also containing vitamin and trace element, such as iron, zinc, manganese, chromium, nutritional ingredient is higher than white granulated sugar very
It is more.【Nature and flavor】It is sweet, gentle, nontoxic.It cures mainly：Trusted subordinate's heat expansion, dry are intended to drink, swelling and sore throat, cough with lung heat, cardiopulmonary and intestine and small intestine
Heat, wine poison.
By the conventional formulation technique of related dosage form, add in appropriate amount of auxiliary materials and corresponding dosage form is made, above-mentioned Chinese medicine preparation may be used also
The dosage form of particle electuary, paste or other Chinese pharmacologies is made.
The preparation method of the ginger green onion cough arresting of present invention treatment allergic cough is made in above-mentioned each component drug：
（1）First by ginger, Bulbus Allii Fistulosi, the tuber of pinellia, Sweet tea shred, add brown sugar, fall after mixing by ratio of weight and the number of copies
Enter extractor, add in 8-10 times of water for medicine gross weight, rear slow fire infusion 1-2 hours is boiled in heating, treats that fluid temperature drops
During to 30-50 DEG C, filtered through 100-120 mesh screens, obtain extracting solution；
（2）The dregs of a decoction after being filtered in step 1 are added in into 3-5 times of water for medicine gross weight, rear infusion 1-2 is boiled in heating
Hour, when fluid temperature is down to 30-50 DEG C, filtered through 100-120 mesh screens, then the extracting solution of step 1 is mixed
Stirring is filtered with after alcohol precipitation 1-2 days to get ginger green onion cough arresting.
Application of the ginger green onion cough arresting in the drug for treating quick property cough.
The beneficial effects of the invention are as follows：
1st, ginger green onion cough arresting of the invention has a heat reliving and toxin-eliminating, relieving cough and reducing sputum, warming middle energizer to arrest vomiting, promoting menstruation facilitaing lung, antiallergy,
The effect of moistening lung；Especially for wind-cold affecting lung, Lung Qi obstruction, impairment of dispersing and descending function of the lung has non-for the allergic cough of main pathogenesis
The effect of often good.
2nd, it can be fully recovered using 1-2 weeks of the present invention, effective percentage reaches more than 95%, has no toxic and side effect to human body, user
Just, cost is with low.
3rd, ginger green onion cough arresting patient of the invention take rear adverse reaction it is few, it is easy cure, uneasy to recur, good effect, nothing
Toxic side effect；And prescription is simple, materials are easy, safe and reliable, economic and practical.
4th, the present invention compares by long-term experiment and repeatedly and makes according to modern Chinese herbal medicine pharmacology, material composition and parts by weight
With, obtained scientific compatibility, mutually to use, it is inseparable, there is good therapeutic effect.
Specific embodiment
Embodiment 1
（One）The parts by weight of ginger green onion cough arresting raw material for treating allergic cough are：
15 parts of ginger, 15 parts of Bulbus Allii Fistulosi, 10 parts of the tuber of pinellia, 10 parts of Sweet tea, 30 parts of brown sugar
（Two）Preparation method includes the following steps：
（1）First by ginger, Bulbus Allii Fistulosi, the tuber of pinellia, Sweet tea shred, add brown sugar, fall after mixing by ratio of weight and the number of copies
Enter extractor, add in 8-10 times of water for medicine gross weight, rear slow fire infusion 1-2 hours is boiled in heating, treats that fluid temperature drops
During to 30-50 DEG C, filtered through 100-120 mesh screens, obtain extracting solution；
（2）The dregs of a decoction after being filtered in step 1 are added in into 3-5 times of water for medicine gross weight, rear infusion 1-2 is boiled in heating
Hour, when fluid temperature is down to 30-50 DEG C, filtered through 100-120 mesh screens, then the extracting solution of step 1 is mixed
Stirring is filtered with after alcohol precipitation 1-2 days to get ginger green onion cough arresting.
Embodiment 2
（One）The parts by weight of ginger green onion cough arresting raw material for treating allergic cough are：
16 parts of ginger, 16 parts of Bulbus Allii Fistulosi, 12 parts of the tuber of pinellia, 12 parts of Sweet tea, 34 parts of brown sugar
（Two）Preparation method is same as Example 1.
Embodiment 3
（One）The parts by weight of ginger green onion cough arresting raw material for treating allergic cough are：
17 parts of ginger, 17 parts of Bulbus Allii Fistulosi, 13 parts of the tuber of pinellia, 13 parts of Sweet tea, 36 parts of brown sugar
（Two）Preparation method is same as Example 1.
Embodiment 4
（One）The parts by weight of ginger green onion cough arresting raw material for treating allergic cough are：
18 parts of ginger, 18 parts of Bulbus Allii Fistulosi, 14 parts of the tuber of pinellia, 14 parts of Sweet tea, 38 parts of brown sugar
（Two）Preparation method is same as Example 1.
Embodiment 5
（One）The parts by weight of ginger green onion cough arresting raw material for treating allergic cough are：
20 parts of ginger, 20 parts of Bulbus Allii Fistulosi, 15 parts of the tuber of pinellia, 15 parts of Sweet tea, 40 parts of brown sugar
（Two）Preparation method is same as Example 1.
Application example
In April, 2014 in April, 2015 our hospital's outpatient clinic allergic cough's clinical patients 100.Inclusion criteria：Symbol
Close the Clinical symptoms of allergic cough.Irritation dry cough, mostly paroxysmal, daytime, night sky can cough, oil smoke, dust, cold sky
Gas, speech etc. easily induce cough, are often accompanied by throat and itch, pulmonary ventilation function is normal, induction of sputum cytoscopy eosinophils
Ratio is not high.
Exclusion criteria：1. it is associated with other diseases；2. fail to complete to treat as required.
Method：Random grouping, control group：50, observation group 50.Control group Western medicine antiallergy, cough-relieving treatment；Observation group
Oral ginger green onion cough-relieving decoction formulation, adds and subtracts according to clinical syndrome differentiation, often takes daily 2 times, 7d is as a treatment course.
Criterion of therapeutical effect：Emerging is passed according to grandson《Clinical disease diagnosis is according to criterion of cure》(M) is drafted.It cures：Treat 1-2
Course for the treatment of cough stops, in a short time without recurrence；It is effective：Cough mitigates more than 2/3；It improves：Cough mitigates more than 1/2；In vain：Treatment
Front and rear no significant change.
The rear curative effect that table 1 treats medication 2 weeks for two groups of allergic cough's clinical patients compares（Example）
| Group | Number of cases | It cures | It is effective | It improves | In vain | It is efficient（%） |
| Treatment group | 50 | 31 | 13 | 4 | 2 | 96 |
| Control group | 50 | 22 | 8 | 5 | 15 | 70 |
Model case 1
Patient Luo, man, 46 years old, due to air pollution, sucking particle was more, leads to irritation dry cough, takes this hair
For bright ginger green onion cough arresting after 7 days, cough mitigates more than 2/3, hence it is evident that improves.
Model case 2
Patient it is deep certain, female, 35 years old, teacher, since recent course is more, classroom speech is more to wait inductions cough, with throat
It itches, swell and ache, after the course for the treatment of 14 days of ginger green onion cough arresting two for taking the present invention, cough stops, in a short time without recurrence.
Model case 3
Patient Mr. Li, male, 43 years old, unknown cause caused paroxysmal fierceness to be coughed, and was steeped with dry cough with a small amount of white
Foam sample sputum, based on dry throat is itched, after the course for the treatment of 14 days of ginger green onion cough arresting two for taking the present invention, cough stops, in a short time without
Recurrence.
Claims (2)
1. a kind of ginger green onion cough arresting for treating allergic cough, it is characterised in that：It is made of the raw material of following parts by weight：It is raw
15-20 parts of ginger, 15-20 parts of Bulbus Allii Fistulosi, 10-15 parts of the tuber of pinellia, 10-15 parts of Sweet tea, 30-40 parts of brown sugar；
The preparation method of the ginger green onion cough arresting is：
（1）First ginger, Bulbus Allii Fistulosi, the tuber of pinellia, Sweet tea are shredded, brown sugar is added, pours into extraction after mixing by ratio of weight and the number of copies
Tank, adds in 8-10 times of water for medicine gross weight, and heating boils rear slow fire infusion 1-2 hours, treats that fluid temperature is down to 30-
At 50 DEG C, filtered through 100-120 mesh screens, obtain extracting solution；
（2）By step（1）The dregs of a decoction after middle filtering add in 3-5 times that water is medicine gross weight, and it is small that rear infusion 1-2 is boiled in heating
When, when fluid temperature is down to 30-50 DEG C, filtered through 100-120 mesh screens, then step（1）Extracting solution mix and stir
It mixes, with filtering after alcohol precipitation 1-2 days to get ginger green onion cough arresting.
2. application of the ginger green onion cough arresting as described in claim 1 in the drug for preparing treatment allergic cough.
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Citations (4)
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| CN101049171A (en) * | 2007-04-30 | 2007-10-10 | 陈江 | Loquat cough-relieving beverage |
| CN103751732A (en) * | 2012-11-01 | 2014-04-30 | 高景涛 | Prescription for treating cough |
| CN104288397A (en) * | 2014-09-15 | 2015-01-21 | 卜春荣 | Traditional Chinese medicine formula for children allergic cough caused by phlegm obstructed reversed flow of qi |
| CN104413209A (en) * | 2013-09-05 | 2015-03-18 | 董晨 | Body-building and cold-preventing tea bag and production method thereof |
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2015
- 2015-06-08 CN CN201510307774.3A patent/CN104888172B/en not_active Expired - Fee Related
Patent Citations (4)
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|---|---|---|---|---|
| CN101049171A (en) * | 2007-04-30 | 2007-10-10 | 陈江 | Loquat cough-relieving beverage |
| CN103751732A (en) * | 2012-11-01 | 2014-04-30 | 高景涛 | Prescription for treating cough |
| CN104413209A (en) * | 2013-09-05 | 2015-03-18 | 董晨 | Body-building and cold-preventing tea bag and production method thereof |
| CN104288397A (en) * | 2014-09-15 | 2015-01-21 | 卜春荣 | Traditional Chinese medicine formula for children allergic cough caused by phlegm obstructed reversed flow of qi |
Non-Patent Citations (2)
| Title |
|---|
| 中药治疗过敏性咳嗽的研究进展;邢雪飞等;《药物评价研究》;20141008;第37卷(第5期);第477页左栏第2段 * |
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Inventor after: Song Zixian Inventor after: He Jianhua Inventor after: Nong Xiaoqun Inventor after: Mo Xinxian Inventor after: Chen Fangzhong Inventor before: Song Zixian Inventor before: Nong Xiaoqun Inventor before: Mo Xinxian Inventor before: He Jianhua Inventor before: Chen Fangzhong |
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| GR01 | Patent grant | ||
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20180710 Termination date: 20210608 |