WO2016183783A1

WO2016183783A1 - Traditional chinese medicine for treating hyperplasia of mammary glands

Info

Publication number: WO2016183783A1
Application number: PCT/CN2015/079226
Authority: WO
Inventors: 张甘霖
Original assignee: 张甘霖
Priority date: 2015-05-18
Filing date: 2015-05-18
Publication date: 2016-11-24

Abstract

Provided is a traditional Chinese medicine for treating hyperplasia of mammary glands. The traditional Chinese medicine is prepared from the following raw medicinal materials in parts by weight: 15 parts of Chinese radish seeds, 15 parts of dandehon herb, 12 parts of curcuma roots, 10 parts of white peony roots, 10 parts of white atractylodes rhizome, 8 parts of bupleurum roots, 8 parts of indian breads, and 5 parts of Chinese angelica.

Description

Traditional Chinese medicine for treating breast hyperplasia

Technical field

The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating breast hyperplasia.

Background technique

Breast hyperplasia is a common breast disease. The naming of this disease is very confusing, also known as lobular hyperplasia, mammary gland dysplasia, fibrocystic disease. The disease is characterized by the proliferation of components of the breast, showing abnormalities in structure, quantity and histomorphology, so it is called cystic hyperplasia or mammary gland dysplasia.

The research status of the medicinal materials involved in the present invention is as follows:

Lai Zizi [Source] This product is a mature seed of the cruciferous plant Laiwu. From May to August, the fruit is fully matured and harvested, dried, and the seeds are removed to remove impurities and stored in a dry place. [Sexual taste] Xin, Gan, Ping. [Return to the spleen] stomach, lung, large intestine. 【Functions and Indications】Digestion and stagnation, lowering gas and phlegm. The staple food is stagnant, the abdominal distension is full, the diarrhea is heavy, and the sputum is heavy; the cough is sputum, and the gas is full and full. [Usage and dosage] 5 ~ 10g.

Dandelion [alias] 凫公英, 蒲公草, 耩褥草, servant pod, servant poppy, diced, calendula, 孛孛丁菜, 黄花苗, 黄花郎, 鹁鸪英,婆婆丁,白鼓Ding, Huanghua Diding, Pugongding, Earweed, Dog Milkweed, Milk Grass, Remnant Pendant, Yellow Dog Head, Budi, Ghost Lantern, Goat Grandma, Shuangyingdi, Huanghuacao, Guguding. [Source] This product is a dried whole grass of the compositae dandelion, alkali dandelion or the same genus. During the spring to autumn, when the flower is first opened, it is excavated to remove impurities, washed and dried. [Sexual taste] bitter, sweet, cold. [Return] to the liver, stomach. 【Indications】 Qingrejiedu, swelling and dispersing, diuretic Tonglin. For hemorrhoids swollen poison, chyle, phlegm, red eyes, sore throat, lung sputum, intestinal fistula, damp heat jaundice, hot dripping pain. [Usage and Dosage] Oral: Jiantang, 15 ~ 30g. [Note] yang deficiency outside the cold, spleen and stomach weakness are hanged. [Excerpt] "Chinese Materia Medica".

Yu Jin [alias] Yujin, Baisi Yujin. [Source] This product is a dry root of the ginger family, such as warm turmeric, turmeric, Guangxi scorpion or scutellaria. The former two are respectively called "Wen Yujin" and "Yellow Silk Yujin", and the rest are called "Gui Yujin" or "Green Silk Yujin" according to different traits. After the winter leaves and leaves are withered, they are excavated to remove sediment and fine roots, steamed or boiled until they are soaked and dried. [Sexual taste] Xin, bitter, cold. [Return] to the liver, heart, lung. [Functions and Indications] qi phlegm, clear heart and stagnation, spleen and yellow. For menstrual dysmenorrhea, chest and abdomen pain, tingling, The fever is faint, the epilepsy is mad, and the jaundice is urinary red. [Usage and dosage] Oral: Jiantang, 3 ~ 9g. [Note] Yin deficiency and blood loss and qi stagnation and blood stasis are not allowed, pregnant women are cautious. [Excerpt] "Chinese Materia Medica".

White 芍 [alias] peony. [Source] This product is the dried root of the peony plant. Excavate in the summer and autumn seasons, wash, remove the head and tail and fine roots, boil in boiling water, remove the skin or peel, then cook and dry. [Sexual taste] bitter, sour, slightly cold. [Return] to the liver, spleen. [Indications] Pinggan pain, nourishing blood, menstruation, yin and antiperspirant. For headache, dizziness, hypochondriac pain, abdominal pain, quadriplegia, blood deficiency, anaerobic, irregular menstruation, spontaneous sweating, night sweats. [Usage and dosage] Oral: Jiantang, 6 ~ 15g. [Note] It should not be used together with the gourd. [Excerpt] "Chinese Materia Medica".

Atractylodes [alias] in surgery, winter surgery, Zhejiang surgery, seed surgery. [Source] This product is the dried rhizome of Atractylodes macrocephala. In the winter, when the lower leaves are yellow and the upper leaves become brittle, they are excavated, removed from the sediment, dried or dried, and then the roots are removed. [Sexual taste] bitter, sweet, warm. [Return to the spleen] stomach, stomach. [Indications] spleen and qi, dampness and water, antiperspirant, and fetus. For spleen deficiency, less bloating, diarrhea, sputum, edema, edema, spontaneous sweating, fetal movement. Earth white surgery spleen, and stomach, fetus. It is used for spleen deficiency, diarrhea and diarrhea, and fetal movement is uneasy. [Usage and dosage] Oral: Jiantang, 6 ~ 12g. [Note] Yin deficiency and thirst, qi stagnation and suffocation should not be served. [Excerpt] "Chinese Materia Medica".

Bupleurum [alias] smoked, simmered, mountain vegetables, grass, firewood. [Source] This product is the dried root of Bupleurum or Bupleurum chinense. According to different traits, they are respectively called "North Bupleurum" and "South Bupleurum". Excavation in spring and autumn, remove stems and leaves and sediment, and dry. [Sexual taste] bitter, slightly cold. [Return] to the liver, gallbladder. [Functions and Indications] In the solution table, Shugan, Shengyang. For colds and fever, cold and heat, chest pain, pain, irregular menstruation, prolapse, prolapse. [Usage and dosage] Oral: Jiantang, 3 ~ 9g. [Note] The dried rhizome of Bupleurum chinense has a dense surface and is toxic. It should not be used as Bupleurum. [Excerpt] "Chinese Materia Medica".

茯苓[alias] 茯苓茯苓, 茯苓 skin, 茯苓 block, red 茯苓, white 茯苓. [Source] This product is a dried sclerotium of the fungus of the Polyporaceae family. More than 7 to 9 months of excavation, remove the sediment after excavation, stack "sweating", spread out to dry the surface, and then "sweating", repeated several times to the current wrinkles, most of the internal moisture lost, dry It is called "茯苓"; or the fresh glutinous rice is cut according to different parts, and dried in the shade, which are called "skin" and "smashing block" respectively. [Sexual taste] sweet, light, flat. [Return] to the heart, lungs, spleen, kidney. [Indications] Lishui soaked, spleen and heart. For edema, oliguria, dizziness, spleen, less spleen, less diarrhea, diarrhea, restlessness, convulsions and insomnia. [Usage and dosage] Oral: Jiantang, 9 ~ 15g. [Note] Those who are debilitated or have a stagnation of qi deficiency should not take it. [Excerpt] "Chinese Materia Medica".

Angelica [alias] dry back. [Source] This product is the dried root of Angelica sinensis. At the end of autumn, the excavation is carried out to remove the roots and sediments. After the water has evaporated slightly, it is bundled into small pieces and placed on the shed, and slowly dried out with fireworks. [Sexual taste] Gan, Xin, Wen. [Return to the classics] to the liver, heart, spleen. 【Indications】Blood and activating blood circulation, regulating menstruation and relieving pain, run Intestines are laxative. For blood deficiency and chlorosis, dizziness, palpitations, irregular menstruation, menstrual cramps, cold and abdominal pain, intestinal dry constipation, rheumatism and pain, fall and fall damage, hemorrhoids. Wine Angelica blood circulation. For menstrual dysmenorrhea, rheumatism, pain, and fall damage. [Usage and Dosage] Oral: Jiantang, 10 ~ 25g. [Note] The wet resistance is full and the stool is suffocating. [Excerpt] "Chinese Materia Medica".

Summary of the invention

The invention aims to provide a traditional Chinese medicine for treating breast hyperplasia, and achieve the purpose of safely and effectively curing breast hyperplasia by selecting appropriate medicinal materials and their ratios.

In order to achieve the above object, the present invention adopts the following technical solutions:

The invention relates to a traditional Chinese medicine for treating breast hyperplasia, which is prepared by the following raw materials of weight ratio: 15 parts of Laiwuzi, 15 parts of dandelion, 10 parts of Yujin Qingxin Jieyu Baiji, 10 parts of Atractylodes 8 parts of Bupleurum, 8 parts of Chinese wolfberry, and 5 parts of Chinese angelica.

Acting on the body's qi and blood, the next behavior. The woman's breast is a stomach, the nipple is a liver, the spleen is easy to qi and blood stasis, the liver stagnation is bloody on the milk, causing breast swelling and pain, causing chyle when it is not scattered for a long time. Expelling blood circulation, soothing the liver and strengthening the spleen.

The invention uses: Chaihu Shugan Jieyu; Yujinqingxinjieyu; Baizhi Rougan pain; Laizizi Jianpi Huayu; Qijian spleen dampness; Baizhu Jianpi Yiqi; Angelica blood and activating blood; Swelling. The combination of various medicines plays a role in promoting blood circulation and removing blood stasis, soothing the liver and strengthening the spleen, and thus effectively treating breast hyperplasia.

The beneficial effects of the present invention will be described below in conjunction with clinical experimental data:

1. General information

Inventors collected a total of 116 outpatients and hospitalized women with breast hyperplasia from October 2012 to October 2013. They were randomly divided into a treatment group of 58 patients and a control group of 58 patients. The treatment group was 18 to 59 years old with an average age of 34 years. The control group was 20 to 56 years old with an average age of 32 years. There were no significant differences in gender, age and duration of disease between the two groups, which were comparable.

Diagnostic criteria

According to the diagnostic criteria of the National Clinical Conference on Mammary Gland Hyperplasia: (1) Patients will have clinical symptoms such as breast tenderness and dull pain, and will continue to have pain for more than 3 months. (2) The patient's breast will have a lump and appear granular or cord-like. Patients with depression before and after menstruation, red tongue and pulse slippery symptoms; (3) nipple discharge: a small number of patients may have nipple discharge, spontaneous discharge, grass yellow or brown serous discharge. (4) menstrual disorders: patients with this disease can also see irregular menstruation before and after, the amount is small or pale, can be associated with dysmenorrhea. (5) Emotional change: patients often have bad emotions or upset and irritated, every time they are angry, nervous or labor Increase after the tired.

2, test methods

2.1 treatment

The treatment group was orally administered the capsule prepared according to the specific example 3 of the present invention 3 times a day. The treatment lasts for one month.

The control group was orally administered with a milk core granule and taken according to its instructions. The treatment lasts for one month.

3, efficacy standards and treatment results

3.1 Efficacy criteria

Cure: breast pain and breast lumps disappeared, no recurrence after 3 months of follow-up;

Significant effect: the diameter of the breast mass decreased to more than 1/2 before the treatment, and the breast pain was significantly reduced;

Effective: breast diameter reduced to less than 1/2 of the pre-treatment, breast pain has been reduced;

Invalid: symptoms such as breast pain and breast lumps have not improved.

3.2 The treatment results are shown in Table 1.

Table 1 Comparison of the two groups

It can be seen that the medicine prepared by the invention can safely and effectively treat breast hyperplasia and has good clinical promotion value.

detailed description

For a better understanding and implementation of the present invention, the invention will be further described in conjunction with the specific embodiments.

Example 1

Weighing: 15 grams of Laiwuzi, 15 grams of dandelion, 12 grams of turmeric, 10 grams of white peony, 10 grams of Atractylodes, 8 grams of Bupleurum, 8 grams of medlar, 5 grams of angelica; plus 8 times the amount of water, boiling for 1.5 hours, Filtration; filter residue plus 6 times the amount of water, boiling for 1 hour, filtration; the filtrate was combined and concentrated to 120 g, which is a decoction that meets the daily dosage of normal adults.

For the treatment of breast hyperplasia. Oral, taken three times a day, morning, evening and evening.

Example 2

Weighing: 15 grams of Laiwuzi, 15 grams of dandelion, 12 grams of turmeric, 10 grams of white peony, 10 grams of Atractylodes, 8 grams of Bupleurum, 8 grams of medlar, 5 grams of angelica; plus 10 times the amount of water, boiling for 2 hours, Filtration; filter residue plus 8 times the amount of water, boiling for 1.5 hours, filtration; the filtrate is combined, concentrated, dried, and packaged, that is, a powder that meets the daily dosage of normal adults.

Example 3

Weighing: 15 grams of Laiwuzi, 15 grams of dandelion, 12 grams of turmeric, 10 grams of white peony, 10 grams of Atractylodes, 8 grams of Bupleurum, 8 grams of medlar, 5 grams of angelica; plus 6 times the amount of water, boiling 3 times, Each time of boiling for 1 hour, the decoction liquid is combined, concentrated, dried, and filled into a capsule shell to obtain a capsule which meets the daily dosage of normal adults.

Claims

A traditional Chinese medicine for treating breast hyperplasia, wherein it is prepared from the following raw materials of weight ratio: 15 parts of Laiwu, 15 parts of dandelion, 12 parts of turmeric, 10 parts of white peony, 10 parts of Atractylodes, and firewood 8 parts of Hu, 8 parts of glutinous rice, 5 parts of angelica.
The traditional Chinese medicine for treating hyperplasia of mammary gland according to claim 1, wherein the preparation method comprises the following steps: weighing: 15 parts of raisin, 15 parts of dandelion, 12 parts of turmeric, 10 parts of white peony, 10 parts of atractylodes, and Bupleurum. 8 parts, 8 parts, 8 parts of angelica; add 8 times the amount of water, decoct for 1.5 hours, filter; add 6 times the amount of water to the filter residue, decoct for 1 hour, filter; combine the filtrate, concentrate to 120 parts, then decoction The above parts are all parts by weight.
The traditional Chinese medicine for treating hyperplasia of mammary gland according to claim 1, wherein the preparation method comprises the following steps: weighing: 15 parts of raisin, 15 parts of dandelion, 12 parts of turmeric, 10 parts of white peony, 10 parts of atractylodes, and Bupleurum. 8 parts, 8 parts, 5 parts of angelica; add 10 times the amount of water, boil for 2 hours, filter; filter residue plus 8 times the amount of water, decoct for 1.5 hours, filter; combine the filtrate, concentrate, dry, package, that is, powder The above parts are all parts by weight.
The traditional Chinese medicine for treating hyperplasia of mammary gland according to claim 1, wherein the preparation method comprises the following steps: weighing: 15 parts of raisin, 15 parts of dandelion, 12 parts of turmeric, 10 parts of white peony, 10 parts of atractylodes, and Bupleurum. 8 parts, 8 parts, 5 parts of angelica; add 6 times the amount of water, decoct 3 times, each time boiling for 1 hour, combine the boiling liquid, concentrate, dry, and put into the capsule shell, that is, capsules; Both refer to parts by weight.