WO2018201549A1 - 含牛奶提取物的保护儿童皮脂膜护肤品 - Google Patents

含牛奶提取物的保护儿童皮脂膜护肤品 Download PDF

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Publication number
WO2018201549A1
WO2018201549A1 PCT/CN2017/087363 CN2017087363W WO2018201549A1 WO 2018201549 A1 WO2018201549 A1 WO 2018201549A1 CN 2017087363 W CN2017087363 W CN 2017087363W WO 2018201549 A1 WO2018201549 A1 WO 2018201549A1
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Prior art keywords
extract
oil
milk
skin care
parts
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PCT/CN2017/087363
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English (en)
French (fr)
Inventor
薛宏英
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小牛哞哞母婴用品(深圳)有限公司
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Publication of WO2018201549A1 publication Critical patent/WO2018201549A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/986—Milk; Derivatives thereof, e.g. butter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the invention belongs to the field of skin care products, in particular to a skin care product specially designed for protecting children's sebum film and containing milk extract.
  • the skin barrier is the outermost layer of human skin. It consists of three parts from the outside to the inside: sebum membrane, keratinocytes, intercellular lipids, which resist harmful, irritating, and sunlight from the outside environment. And to regulate the anti-inflammatory effect, skin barrier damage will cause dry skin, aging, hyperpigmentation atopic dermatitis, eczema, solar dermatitis and other skin problems.
  • the sebum membrane is formed by the sebum secreted by the sebaceous glands, the lipid produced by the disintegration of the stratum corneum cells and the sweat secreted by the sweat glands, which has the function of locking in moisture, protecting keratinocytes and intercellular lipids, and It is acidic and has certain anti-infective and anti-inflammatory effects. Therefore, if you want to be healthy, you must first protect the sebum membrane.
  • the technical problem to be solved by the present invention is that the skin care products of the prior art mostly play a role in treating skin inflammation, and have no effect of preventing problems of the sebum film, thereby proposing a protective film for children to protect the skin.
  • Milk extract for skin care products are not limited to the above mentioned skin care products.
  • the technical solution of the present invention is:
  • the invention provides a skin care product specially designed for protecting children's sebum film and containing milk extract, which comprises the following ingredients in parts by weight:
  • the milk extract is one or more of hydrolyzed milk protein, lactoglobulin, lactoferrin, whey protein;
  • the vegetable oil is olive oil, almond oil, jojoba oil, or wheat germ or One or more of squalane, avocado oil, shea butter, grape seed oil, Qiongyao jellyfish oil, borage oil, and linseed oil extracted from rice bran.
  • the milk extract is composed of hydrolyzed milk protein, lactoglobulin, lactoferrin, and whey protein, and the mass ratio of the above extract is 30-50:5-10:11-18:4-9.
  • the vegetable oil is derived from olive oil, almond oil, jojoba oil, squalane extracted from wheat germ or rice bran, avocado oil, shea butter, grape seed oil, hollywood jellyfish oil, borage oil And linseed oil composition, the mass ratio of each of the above vegetable oils is 10-15:5-10:15-20:3-6:10-15:8-15:10-16:4-8:3-5:5 -9.
  • 3-5 parts of the medlar extract; and 5-8 parts of the Echinacea extract are further included.
  • the hydrolyzed milk protein is extracted by using a protease to hydrolyze milk, and the enzymatic hydrolysate is heated at 40-60 ° C and then filtered.
  • the filtered hydrolyzed milk protein has a molecular mass of less than 500 Daltons.
  • the aloe extract is prepared by peeling aloe leaves, grinding them into a slurry, removing the cellulose therein, and filtering the 0.45 ⁇ m filter membrane to obtain an aloe extract.
  • the oat extract is prepared by mixing the pulverized oat with glycerin and deionized water, the mass ratio of oat, glycerin and water is 1:2:20, heating the mixture to 70-80 ° C, stirring After 1-2 h, extraction was carried out to obtain an oat extract; the alfalfa extract contained 30% of lycium polysaccharide.
  • the skin care product can be a liquid, an emulsion, a cleansing agent, a soap, an oil, a cream or a spray.
  • a skin care product for protecting a child's sebum film and containing a milk extract which comprises, by weight, the following ingredients: milk extract 50-85 parts; vegetable oil 30-55 parts; ceramide 5-10 parts; aloe extract 10-16 parts; oat extract 6-10 parts.
  • the child skin care product formula contains milk extract, the milk extract is a small molecular segment extracted from milk, the larger molecule is more easily absorbed, and the nutrient composition of the milk is retained, and the milk extract also contains water and minerals.
  • Substances sodium, potassium, calcium, magnesium, phosphorus, etc.
  • lipids amino acids
  • the water, mineral lipids and amino acids are similar to human sebum membrane components, forming a thin protective film on the skin surface, which has a good protective effect on children's skin, while fat-soluble vitamins and water-soluble vitamins prevent skin. Dry, rough, itching, desquamation, dermatitis and other skin problems, but also for eczema, and can promote wound healing, prevent skin frostbite, chapped.
  • the skin care product for protecting a child's sebum film and containing milk extract according to the present invention wherein the milk extract is one or more of hydrolyzed milk protein, lactoglobulin, lactoferrin, and whey protein.
  • the vegetable oil is olive oil, almond oil, jojoba oil, squalane extracted from wheat germ or rice bran, avocado oil, shea butter, grape seed oil, hollywood jellyfish oil, borage oil, One or several of linseed oil.
  • the above vegetable oil is a natural source of oil, mild and non-irritating, contains triglycerides and unsaturated fatty acids, can effectively moisturize children's skin, prevent problems such as dryness, itching, inflammation, etc., and the above vegetable oil mixture and milk extract such as hydrolyzed milk protein After blending, it can simulate the composition of the human sebum membrane.
  • This composition which is almost the same as the human sebum membrane, can protect the baby's sebum membrane and protect the skin.
  • the present embodiment provides a skin care product specially designed for protecting children's sebum film and containing milk extract, which comprises the following ingredients in parts by weight: milk extract 50 parts, 55 parts of vegetable oil, 5 parts of ceramide, 16 parts of aloe extract, oat extract 6 parts, also include conventional auxiliaries such as glycerin and butylene glycol.
  • the vegetable oil is grape seed oil
  • the milk extract is hydrolyzed milk protein
  • the hydrolyzed milk protein is extracted from milk by enzymatic hydrolysis: firstly, the milk is obtained by enzymatic hydrolysis according to a conventional enzymatic hydrolysis process, and trypsin is used.
  • Pepsin or neutral protease hydrolyzes milk at 45-55 ° C for 3-5 h, then heats the enzymatic hydrolysate at 40 ° C, then performs ultrafiltration to select small molecular peptides with a molecular mass of less than 500 Daltons.
  • the hydrolyzed milk protein is obtained, and the preparation process can decompose the macromolecular protein which cannot be absorbed by the skin into an easily absorbable small molecule polypeptide, and retain important nutrients in the milk.
  • the aloe extract is prepared by washing and peeling the aloe leaves, grinding into a slurry, removing the cellulose therein, and filtering with a 0.45 ⁇ m microporous filtration membrane.
  • the oat extract is prepared by pulverizing oats and mixing with glycerin and deionized water.
  • the mass ratio of broken oats, glycerin and water is 1:2:20, and the mixture is heated to 70 ° C and stirred for 1 h. Extraction at 85 ° C, that is, oat extract.
  • the ceramide acts as a moisturizing agent, can maintain the integrity of the sebum membrane, and is also a main component of the intercellular lipid, has a strong hydration, and can maintain the skin moisturizing.
  • the child's skin care product may be any one of a liquid, an emulsion, a cleansing agent, a soap, an oil, a cream or a spray.
  • the present embodiment provides a skin care product specially designed for protecting children's sebum film and containing milk extract, which comprises the following ingredients in parts by weight: milk extract 85 parts, 30 parts of vegetable oil, 10 parts of ceramide, 10 parts of aloe extract, oat extract 10 parts also include conventional auxiliaries such as glycerin and butylene glycol.
  • the milk extract is composed of lactoglobulin and hydrolyzed milk protein, and the mass ratio of the two is 1:9, and the hydrolyzed milk protein is extracted from the milk by enzymatic hydrolysis:
  • the enzymatic hydrolysate is prepared according to the conventional enzymatic hydrolysis process, and the hydrolyzed milk is hydrolyzed by trypsin, pepsin or neutral protease at 45-55 ° C for 3-5 h, and then the enzymatic hydrolyzed product is heated at 60 ° C, after which Ultrafiltration is carried out to select small molecular peptides with a molecular mass of less than 500 Daltons to obtain hydrolyzed milk protein.
  • the preparation process can decompose macromolecular proteins that cannot be absorbed by the skin into easily absorbed small molecular polypeptides, and retain important in milk.
  • Nutritional ingredients The aloe extract is prepared by washing and peeling the aloe leaves, grinding into a slurry, removing the cellulose therein, and filtering with a 0.45 ⁇ m microporous filtration membrane.
  • the oat extract is prepared by pulverizing oats and mixing with glycerin and deionized water. The mass ratio of broken oats, glycerin and water is 1:2:20, and the mixture is heated to 80 ° C and stirred for 2 h. The extract is obtained at 90 ° C to obtain an oat extract.
  • the ceramide acts as a moisturizing agent, can maintain the integrity of the sebum membrane, and is also a main component of the intercellular lipid, has a strong hydration, and can maintain the skin moisturizing.
  • the vegetable oil is composed of olive oil, almond oil, jojoba oil, squalane extracted from wheat germ or rice bran, and the mass ratio of each of the above vegetable oils is 10:10:1:6.
  • the child's skin care product may be any one of a liquid, an emulsion, a cleansing agent, a soap, an oil, a cream or a spray.
  • the present embodiment provides a skin care product for protecting children's sebum film and containing milk extract, which comprises the following ingredients in parts by weight: 60 parts of milk extract, 42 parts of vegetable oil, 8 parts of ceramide, aloe extract 13
  • the oat extract is 8 parts, and also includes conventional auxiliaries such as glycerin and butylene glycol.
  • the milk extract is composed of hydrolyzed milk protein, lactoglobulin, lactoferrin, whey protein, and the mass ratio of the above extract is 30:5:11:4, and the hydrolyzed milk protein is hydrolyzed by milk.
  • the enzymatic hydrolysate is prepared according to the conventional enzymatic hydrolysis process, and the hydrolyzed milk is hydrolyzed by trypsin, pepsin or neutral protease at 45-55 ° C for 3-5 h, and then the enzymatic hydrolyzed product is heated at 50 ° C, after which Ultrafiltration is carried out to select small molecular peptides with a molecular mass of less than 500 Daltons to obtain hydrolyzed milk protein.
  • the preparation process can decompose macromolecular proteins that cannot be absorbed by the skin into easily absorbed small molecular polypeptides, and retain important in milk. Nutritional ingredients.
  • the aloe extract is prepared by washing and peeling the aloe leaves, grinding into a slurry, removing the cellulose therein, and filtering with a 0.45 ⁇ m microporous filtration membrane.
  • the oat extract is prepared by pulverizing oats and mixing with glycerin and deionized water. The mass ratio of broken oats, glycerin and water is 1:2:20, and the mixture is heated to 75 ° C and stirred for 1.5 h. Extracted at 90 ° C to obtain oat extract.
  • the ceramide acts as a moisturizing agent, can maintain the integrity of the sebum membrane, and is also a main component of the intercellular lipid, has a strong hydration, and can maintain the skin moisturizing.
  • the vegetable oil is derived from olive oil, almond oil, jojoba oil, squalane extracted from wheat germ or rice bran, avocado oil, shea butter, grape seed oil, hollywood jellyfish oil, borage oil, linseed
  • the oil composition, the mass ratio of each of the above vegetable oils is 15:5:20:3: 15:8:16:4:5:5.
  • the child's skin care product may be any one of a liquid, an emulsion, a cleansing agent, a soap, an oil, a cream or a spray.
  • the present embodiment provides a skin care product specially designed for protecting children's sebum film and containing milk extract, which comprises the following components in parts by weight: 75 parts of milk extract, 55 parts of vegetable oil, 5 parts of ceramide, and aloe extract 16 , oat extract 6 parts, alfalfa extract 5 parts; echinacea extract 5 parts, also include conventional auxiliaries such as glycerin and butylene glycol.
  • the milk extract is composed of hydrolyzed milk protein, lactoglobulin, lactoferrin, whey protein, and the mass ratio of the above extract is 50:10:18:9, and the hydrolyzed milk protein is hydrolyzed by milk.
  • the enzymatic hydrolysate is prepared according to the conventional enzymatic hydrolysis process, and the hydrolyzed milk is hydrolyzed by trypsin, pepsin or neutral protease at 45-55 ° C for 3-5 h, and then the enzymatic hydrolyzed product is heated at 40 ° C, after which Ultrafiltration is carried out to select small molecular peptides with a molecular mass of less than 500 Daltons to obtain hydrolyzed milk protein.
  • the preparation process can decompose macromolecular proteins that cannot be absorbed by the skin into easily absorbed small molecular polypeptides, and retain important in milk. Nutritional ingredients.
  • the aloe extract is prepared by washing and peeling the aloe leaves, grinding into a slurry, removing the cellulose therein, and filtering with a 0.45 ⁇ m microporous filtration membrane.
  • the oat extract is prepared by pulverizing oats and mixing with glycerin and deionized water. The mass ratio of broken oats, glycerin and water is 1:2:20, and the mixture is heated to 70 ° C and stirred for 2 h. Extraction at 80 ° C, that is, oat extract.
  • the ceramide acts as a moisturizing agent, can maintain the integrity of the sebum membrane, and is also a main component of the intercellular lipid, has a strong hydration, and can maintain the skin moisturizing.
  • the alfalfa extract contains 30% of sorghum polysaccharide, which is a commercially available echinacea stem and leaf extract.
  • the vegetable oil is derived from olive oil, almond oil, jojoba oil, squalane extracted from wheat germ or rice bran, avocado oil, shea butter, grape seed oil, hollywood jellyfish oil, borage oil, linseed
  • the oil composition, the mass ratio of each of the above vegetable oils is 10:10:15:6:10:15:10:8:3:9.
  • the child's skin care product may be any one of a liquid, an emulsion, a cleansing agent, a soap, an oil, a cream or a spray.
  • the present embodiment provides a skin care product specially designed for protecting children's sebum film and containing milk extract, which comprises the following ingredients in parts by weight: milk extract 65 parts, 30 parts of vegetable oil, 10 parts of ceramide, 10 parts of aloe extract, 10 parts of oat extract, 3 parts of medlar extract, and also include conventional auxiliaries such as glycerin and butylene glycol; and 8 parts of Echinacea extract.
  • the milk extract is composed of hydrolyzed milk protein, lactoglobulin, lactoferrin, whey protein, and the mass ratio of the above extract is 40:8:15:7, and the hydrolyzed milk protein is extracted from milk by enzymatic hydrolysis.
  • the enzymatic hydrolysate is prepared according to the conventional enzymatic hydrolysis process, and the hydrolyzed milk is hydrolyzed by trypsin, pepsin or neutral protease at 45-55 ° C for 3-5 h, and then the enzymatic hydrolyzed product is heated at 58 ° C, after which Ultrafiltration is carried out to select small molecular peptides with a molecular mass of less than 500 Daltons to obtain hydrolyzed milk protein.
  • the preparation process can decompose macromolecular proteins that cannot be absorbed by the skin into easily absorbed small molecular polypeptides, and retain important in milk. Nutritional ingredients.
  • the aloe extract is prepared by washing and peeling the aloe leaves, grinding into a slurry, removing the cellulose therein, and filtering with a 0.45 ⁇ m microporous filtration membrane.
  • the oat extract is prepared by pulverizing oats and mixing with glycerin and deionized water. The mass ratio of broken oats, glycerin and water is 1:2:20, and the mixture is heated to 75 ° C and stirred for 1.8 h. Extraction at 85 ° C gives an oat extract.
  • the ceramide acts as a moisturizing agent, can maintain the integrity of the sebum membrane, and is also a main component of the intercellular lipid, has a strong hydration, and can maintain the skin moisturizing.
  • the alfalfa extract contains 30% of sorghum polysaccharide, which is a commercially available echinacea stem and leaf extract.
  • the vegetable oil is derived from olive oil, almond oil, jojoba oil, squalane extracted from wheat germ or rice bran, avocado oil, shea butter, grape seed oil, hollywood jellyfish oil, borage oil, linseed
  • the oil composition, the mass ratio of each of the above vegetable oils is 12:7:17:4:12:11:14:6:4:8.
  • the child's skin care product may be any one of a liquid, an emulsion, a cleansing agent, a soap, an oil, a cream or a spray.
  • the present embodiment provides a skin care product specially designed for protecting children's sebum film and containing milk extract, which comprises the following components in parts by weight: milk extract 68 parts, vegetable oil 40 parts, ceramide 7 parts, aloe extract 12 Portion, 8 parts of oat extract, 4 parts of alfalfa extract, 7 parts of Echinacea extract, and also include conventional auxiliaries such as glycerin and butylene glycol.
  • the milk extract is composed of hydrolyzed milk protein, lactoglobulin, lactoferrin, whey protein, and the mass ratio of the above extract is 37:7.5:16:6.5, and the hydrolyzed milk protein is extracted from milk by enzymatic hydrolysis.
  • the enzymatic hydrolysate is prepared according to the conventional enzymatic hydrolysis process, and the hydrolyzed milk is hydrolyzed by trypsin, pepsin or neutral protease at 45-55 ° C for 3-5 h, and then the enzymatic hydrolyzed product is heated at 50 ° C, after which Ultrafiltration is carried out to select small molecular peptides with a molecular mass of less than 500 Daltons to obtain hydrolyzed milk protein.
  • the preparation process can decompose macromolecular proteins that cannot be absorbed by the skin into easily absorbed small molecular polypeptides, and retain important in milk. Nutritional ingredients.
  • the aloe extract is prepared by washing and peeling the aloe leaves, grinding into a slurry, removing the cellulose therein, and filtering with a 0.45 ⁇ m microporous filtration membrane.
  • the oat extract is prepared by pulverizing oats and mixing with glycerin and deionized water. The mass ratio of broken oats, glycerin and water is 1:2:20, and the mixture is heated to 75 ° C and stirred for 2 h. Extraction at 80 ° C, that is, oat extract.
  • the ceramide acts as a moisturizing agent, can maintain the integrity of the sebum membrane, and is also a main component of the intercellular lipid, has a strong hydration, and can maintain the skin moisturizing.
  • the alfalfa extract contains 30% of sorghum polysaccharide, which is a commercially available echinacea stem and leaf extract.
  • the vegetable oil is derived from olive oil, almond oil, jojoba oil, squalane extracted from wheat germ or rice bran, avocado oil, shea butter, grape seed oil, hollywood jellyfish oil, borage oil, linseed
  • the oil composition, the mass ratio of each of the above vegetable oils is 13.5:8.6:16:4.2:13:12:13.5:6:3.9:6.
  • the child's skin care product may be any one of a liquid, an emulsion, a cleansing agent, a soap, an oil, a cream or a spray.

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Abstract

一种保护儿童皮脂膜的护肤品，以重量份计，包括：牛奶提取物10-35份、植物油30-55份、神经酰胺5-10份、芦荟提取物10-16份和燕麦提取物6-10份。该产品中含有水解牛奶蛋白等提取物，植物油与水解牛奶蛋白复配后能够模拟人体皮脂膜的成分，可以起到良好的保护婴幼儿皮脂膜、保护皮肤的作用。

Description

[根据细则37.2由ISA制定的发明名称]　含牛奶提取物的保护儿童皮脂膜护肤品
技术领域
本发明属于护肤品领域，具体地说涉及一种专为保护儿童皮脂膜、含有牛奶提取物的护肤品。
背景技术
皮肤屏障是人体皮肤的最外层保护层，其从外至内由三部分组成：皮脂膜、角质细胞、细胞间脂质，起到抵御外界环境中有害、刺激物、日光进入，同时具有保湿及调节抗炎作用，皮肤屏障受损则会引起皮肤干燥、老化、色素沉着异位性皮炎、湿疹、日光性皮炎等皮肤问题。
皮肤屏障的结构中，皮脂膜由皮脂腺分泌的皮脂、角质层细胞崩解产生的脂质与汗腺分泌的汗液乳化而成，具有锁住水分、保护角质细胞和细胞间脂质的作用，同时其呈酸性，具有一定抗感染、抗炎的作用，因此，若想皮肤健康，首先要保护好皮脂膜。
然而，儿童 由于尚未发育完全，皮肤在结构和功能上与成人的皮肤有所不同，儿童皮肤外观 平滑、细嫩、纹理不清，且皮脂分泌少、细胞间脂质松软，对外界的物理性、化学性、机械性、生物性的侵袭抵御能力较弱，如果不注意护理，会导致皮肤出现如下问题：（1）皮肤的滋润度不够，易出现干燥、脱屑、瘙痒、发红；（2）皮肤的防御力不足导致病菌易侵入皮肤，引起特异性皮炎、湿疹等病症。
为了保护儿童皮肤，越来越多的“儿童专用”、“婴儿专用”的护肤品在市场走俏，但是市面上的很多儿童护肤品成分与成人护肤品无异，并不能真正起到保护儿童皮肤的作用，同时，已有的儿童护肤品多采用抗炎舒缓的原料，起到的是治疗皮肤炎症的作用，而不具备预防皮脂膜出现问题的作用。
发明内容
为此，本发明所要解决的技术问题在于现有技术中的儿童护肤品多起到治疗皮肤炎症的作用，并无预防皮脂膜出现问题的作用，从而提出一种专为保护儿童皮脂膜、含有牛奶提取物的护肤品。
为解决上述技术问题，本发明的技术方案为：
本发明提供一种专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其以重量份计，包括以下成分：
牛奶提取物 50-85份；
植物油 30-55份；
神经酰胺 5-10份；
芦荟提取物 10-16份；
燕麦提取物 6-10份。
作为优选，所述牛奶提取物为水解牛奶蛋白、乳球蛋白、乳铁蛋白、乳清蛋白中的一种或几种；所述植物油为橄榄油、杏仁油、霍霍巴油、由麦胚或米糠中提取的角鲨烷、牛油果油、乳木果油、葡萄籽油、琼崖海棠果油、琉璃苣油、亚麻籽油中的一种或几种。
作为优选，所述牛奶提取物由水解牛奶蛋白、乳球蛋白、乳铁蛋白、乳清蛋白组成，上述提取物的质量比为30-50:5-10:11-18:4-9。
作为优选，所述植物油由橄榄油、杏仁油、霍霍巴油、由麦胚或米糠中提取的角鲨烷、牛油果油、乳木果油、葡萄籽油、琼崖海棠果油、琉璃苣油、亚麻籽油组成，上述各植物油的质量比为10-15：5-10：15-20：3-6：10-15：8-15：10-16：4-8：3-5：5-9。
作为优选，以重量份计，还包括枸杞提取物3-5份；紫锥菊提取物5-8份。
作为优选，所述水解牛奶蛋白的提取过程为：采用蛋白酶酶解牛奶的方法制得酶解产物，对酶解产物在40-60℃下加热后进行过滤即得。
作为优选，过滤后的水解牛奶蛋白的分子质量小于500道尔顿。
作为优选，所述芦荟提取物采用如下方式制备：将芦荟叶去皮后研磨成浆，去除其中的纤维素，并由0.45μm的过滤膜过滤即得芦荟提取物。
作为优选，所述燕麦提取物采用如下方式制备：将粉碎的燕麦与甘油和去离子水混合，燕麦、甘油、水的质量比为1:2:20，将混合物加热至70-80℃，搅拌1-2h后进行萃取，即得燕麦提取物；所述枸杞提取物中含有30%的枸杞多糖。
作为优选，所述护肤品可以为水剂、乳剂、清洁剂、肥皂、油剂、膏霜或喷雾剂。
本发明的上述技术方案相比现有技术具有以下优点：
（1）本发明所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其以重量份计，包括如下成分：牛奶提取物 50-85份；植物油 30-55份；神经酰胺 5-10份；芦荟提取物 10-16份；燕麦提取物 6-10份。所述儿童护肤品配方中含有牛奶提取物，牛奶提取物是从牛奶中提取出的小分子段，其较大分子更易吸收，且保留了牛奶的营养成分，同时牛奶提取物还含有水、矿物质（钠、钾、钙、镁、磷等）、脂类、氨基酸、脂溶性维生素A、D、E，水溶性维生素B5、C，营养物质丰富，适用于皮肤娇嫩的儿童和敏感皮肤，其中的水、矿物质脂类、氨基酸与人体皮脂膜成分相近，可在皮肤表面形成一层轻薄的保护膜，对儿童皮肤具有良好的保护作用，而脂溶性维生素和水溶性维生素则起到防止皮肤干燥、粗糙、瘙痒、脱屑、皮炎等皮肤问题，还对于湿疹具有疗效，且能促进伤口愈合，预防皮肤冻疮、皲裂。
（2）本发明所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，所述牛奶提取物为水解牛奶蛋白、乳球蛋白、乳铁蛋白、乳清蛋白中的一种或几种；所述植物油为橄榄油、杏仁油、霍霍巴油、由麦胚或米糠中提取的角鲨烷、牛油果油、乳木果油、葡萄籽油、琼崖海棠果油、琉璃苣油、亚麻籽油中的一种或几种。上述植物油是天然来源的油脂，温和无刺激，含有甘油三酯和不饱和脂肪酸，能够有效滋润儿童皮肤，预防干燥、瘙痒、炎症等问题的发生，上述植物油混合物与水解牛奶蛋白等牛奶提取物复配后能够模拟出人体皮脂膜的成分，这种与人体皮脂膜几近相同的组合物可以起到良好的保护婴幼儿皮脂膜、保护皮肤的作用。
具体实施方式
为了使本发明的内容更容易被清楚的理解，下面根据本发明的具体实施例对本发明作进一步详细的说明。
实施例1
本实施例提供一种专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其以重量份计，包括以下成分：牛奶提取物 50份，植物油55份，神经酰胺 5份，芦荟提取物16份，燕麦提取物 6份，还包括甘油、丁二醇等常规助剂。其中，所述植物油为葡萄籽油，所述牛奶提取物为水解牛奶蛋白，所述水解牛奶蛋白通过酶解法由牛奶中提取:首先按照常规酶解工艺将牛奶制得酶解产物,采用胰蛋白酶、胃蛋白酶或中性蛋白酶在45-55℃下水解牛奶3-5h，然后在40℃下对酶解产物进行加热处理，之后进行超滤，选取分子质量小于500道尔顿的小分子多肽，即得水解牛奶蛋白，该制备工艺可以将皮肤无法吸收的大分子蛋白质分解为易吸收的小分子多肽，并保留了牛奶中重要的营养成分。所述芦荟提取物采用如下方式制备：将芦荟叶洗净去皮后研磨成浆，去除其中的纤维素后用0.45μm的微孔过滤膜过滤即得。所述燕麦提取物采用如下方式制备：将燕麦粉碎后与甘油和去离子水混合，碎燕麦、甘油、水的质量比为1:2:20，将混合物加热到70℃并搅拌1h后，在85℃下萃取，即得燕麦提取物。所述神经酰胺起到保湿剂的作用，能维持皮脂膜的完整，同时也是细胞间脂质的主要成分，具有较强的水合作用，能够保持皮肤的滋润。
所述儿童护肤品可以为水剂、乳剂、清洁剂、肥皂、油剂、膏霜或喷雾剂中的任一种。
实施例2
本实施例提供一种专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其以重量份计，包括以下成分：牛奶提取物 85份，植物油30份，神经酰胺10份，芦荟提取物10份，燕麦提取物 10份，还包括甘油、丁二醇等常规助剂。其中，牛奶提取物由乳球蛋白和水解牛奶蛋白组成，二者的质量比为1:9，所述水解牛奶蛋白通过酶解法由牛奶中提取: 首先按照常规酶解工艺将牛奶制得酶解产物,采用胰蛋白酶、胃蛋白酶或中性蛋白酶在45-55℃下水解牛奶3-5h，然后在60℃下对酶解产物进行加热处理，之后进行超滤，选取分子质量小于500道尔顿的小分子多肽，即得水解牛奶蛋白，该制备工艺可以将皮肤无法吸收的大分子蛋白质分解为易吸收的小分子多肽，并保留了牛奶中重要的营养成分。所述芦荟提取物采用如下方式制备：将芦荟叶洗净去皮后研磨成浆，去除其中的纤维素后用0.45μm的微孔过滤膜过滤即得。所述燕麦提取物采用如下方式制备：将燕麦粉碎后与甘油和去离子水混合，碎燕麦、甘油、水的质量比为1:2:20，将混合物加热到80℃并搅拌2h后，在90℃下萃取，即得燕麦提取物。所述神经酰胺起到保湿剂的作用，能维持皮脂膜的完整，同时也是细胞间脂质的主要成分，具有较强的水合作用，能够保持皮肤的滋润。
所述植物油由橄榄油、杏仁油、霍霍巴油、由麦胚或米糠中提取的角鲨烷组成，上述各植物油的质量比为10：10：1：6。
所述儿童护肤品可以为水剂、乳剂、清洁剂、肥皂、油剂、膏霜或喷雾剂中的任一种。
实施例3
本实施例提供一种专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其以重量份计，包括以下成分：牛奶提取物60份，植物油42份，神经酰胺8份，芦荟提取物13份，燕麦提取物8份，还包括甘油、丁二醇等常规助剂。其中，所述牛奶提取物由水解牛奶蛋白、乳球蛋白、乳铁蛋白、乳清蛋白组成，上述提取物的质量比为30:5:11:4，所述水解牛奶蛋白通过酶解法由牛奶中提取: 首先按照常规酶解工艺将牛奶制得酶解产物,采用胰蛋白酶、胃蛋白酶或中性蛋白酶在45-55℃下水解牛奶3-5h，然后在50℃下对酶解产物进行加热处理，之后进行超滤，选取分子质量小于500道尔顿的小分子多肽，即得水解牛奶蛋白，该制备工艺可以将皮肤无法吸收的大分子蛋白质分解为易吸收的小分子多肽，并保留了牛奶中重要的营养成分。所述芦荟提取物采用如下方式制备：将芦荟叶洗净去皮后研磨成浆，去除其中的纤维素后用0.45μm的微孔过滤膜过滤即得。所述燕麦提取物采用如下方式制备：将燕麦粉碎后与甘油和去离子水混合，碎燕麦、甘油、水的质量比为1:2:20，将混合物加热到75℃并搅拌1.5h后，在90℃下萃取，即得燕麦提取物。所述神经酰胺起到保湿剂的作用，能维持皮脂膜的完整，同时也是细胞间脂质的主要成分，具有较强的水合作用，能够保持皮肤的滋润。
所述植物油由橄榄油、杏仁油、霍霍巴油、由麦胚或米糠中提取的角鲨烷、牛油果油、乳木果油、葡萄籽油、琼崖海棠果油、琉璃苣油、亚麻籽油组成，上述各植物油的质量比为15：5：20：3： 15：8：16：4：5：5。
所述儿童护肤品可以为水剂、乳剂、清洁剂、肥皂、油剂、膏霜或喷雾剂中的任一种。
实施例4
本实施例提供一种专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其以重量份计，包括以下成分：牛奶提取物75份，植物油55份，神经酰胺5份，芦荟提取物16份，燕麦提取物6份，枸杞提取物5份；紫锥菊提取物 5份，还包括甘油、丁二醇等常规助剂。其中，所述牛奶提取物由水解牛奶蛋白、乳球蛋白、乳铁蛋白、乳清蛋白组成，上述提取物的质量比为50:10:18:9，所述水解牛奶蛋白通过酶解法由牛奶中提取: 首先按照常规酶解工艺将牛奶制得酶解产物,采用胰蛋白酶、胃蛋白酶或中性蛋白酶在45-55℃下水解牛奶3-5h，然后在40℃下对酶解产物进行加热处理，之后进行超滤，选取分子质量小于500道尔顿的小分子多肽，即得水解牛奶蛋白，该制备工艺可以将皮肤无法吸收的大分子蛋白质分解为易吸收的小分子多肽，并保留了牛奶中重要的营养成分。所述芦荟提取物采用如下方式制备：将芦荟叶洗净去皮后研磨成浆，去除其中的纤维素后用0.45μm的微孔过滤膜过滤即得。所述燕麦提取物采用如下方式制备：将燕麦粉碎后与甘油和去离子水混合，碎燕麦、甘油、水的质量比为1:2:20，将混合物加热到70℃并搅拌2h后，在80℃下萃取，即得燕麦提取物。所述神经酰胺起到保湿剂的作用，能维持皮脂膜的完整，同时也是细胞间脂质的主要成分，具有较强的水合作用，能够保持皮肤的滋润。所述枸杞提取物中含有30%的枸杞多糖，所述紫雏菊提取物为市售的紫锥菊茎叶提取物。
所述植物油由橄榄油、杏仁油、霍霍巴油、由麦胚或米糠中提取的角鲨烷、牛油果油、乳木果油、葡萄籽油、琼崖海棠果油、琉璃苣油、亚麻籽油组成，上述各植物油的质量比为10：10：15：6：10：15：10：8：3：9。
所述儿童护肤品可以为水剂、乳剂、清洁剂、肥皂、油剂、膏霜或喷雾剂中的任一种。
实施例5
本实施例提供一种专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其以重量份计，包括以下成分：牛奶提取物 65份，植物油30份，神经酰胺10份，芦荟提取物10份，燕麦提取物10份，枸杞提取物3份，还包括甘油、丁二醇等常规助剂；紫锥菊提取物8份。其中，牛奶提取物由水解牛奶蛋白、乳球蛋白、乳铁蛋白、乳清蛋白组成，上述提取物的质量比为40:8:15:7，所述水解牛奶蛋白通过酶解法由牛奶中提取: 首先按照常规酶解工艺将牛奶制得酶解产物,采用胰蛋白酶、胃蛋白酶或中性蛋白酶在45-55℃下水解牛奶3-5h，然后在58℃下对酶解产物进行加热处理，之后进行超滤，选取分子质量小于500道尔顿的小分子多肽，即得水解牛奶蛋白，该制备工艺可以将皮肤无法吸收的大分子蛋白质分解为易吸收的小分子多肽，并保留了牛奶中重要的营养成分。所述芦荟提取物采用如下方式制备：将芦荟叶洗净去皮后研磨成浆，去除其中的纤维素后用0.45μm的微孔过滤膜过滤即得。所述燕麦提取物采用如下方式制备：将燕麦粉碎后与甘油和去离子水混合，碎燕麦、甘油、水的质量比为1:2:20，将混合物加热到75℃并搅拌1.8h后，在85℃下萃取，即得燕麦提取物。所述神经酰胺起到保湿剂的作用，能维持皮脂膜的完整，同时也是细胞间脂质的主要成分，具有较强的水合作用，能够保持皮肤的滋润。所述枸杞提取物中含有30%的枸杞多糖，所述紫雏菊提取物为市售的紫锥菊茎叶提取物。
所述植物油由橄榄油、杏仁油、霍霍巴油、由麦胚或米糠中提取的角鲨烷、牛油果油、乳木果油、葡萄籽油、琼崖海棠果油、琉璃苣油、亚麻籽油组成，上述各植物油的质量比为12：7：17：4：12：11：14：6：4：8。
所述儿童护肤品可以为水剂、乳剂、清洁剂、肥皂、油剂、膏霜或喷雾剂中的任一种。
实施例6
本实施例提供一种专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其以重量份计，包括以下成分：牛奶提取物68份，植物油40份，神经酰胺7份，芦荟提取物12份，燕麦提取物8份，枸杞提取物4份，紫锥菊提取物7份，还包括甘油、丁二醇等常规助剂。其中，牛奶提取物由水解牛奶蛋白、乳球蛋白、乳铁蛋白、乳清蛋白组成，上述提取物的质量比为37:7.5:16:6.5，所述水解牛奶蛋白通过酶解法由牛奶中提取: 首先按照常规酶解工艺将牛奶制得酶解产物,采用胰蛋白酶、胃蛋白酶或中性蛋白酶在45-55℃下水解牛奶3-5h，然后在50℃下对酶解产物进行加热处理，之后进行超滤，选取分子质量小于500道尔顿的小分子多肽，即得水解牛奶蛋白，该制备工艺可以将皮肤无法吸收的大分子蛋白质分解为易吸收的小分子多肽，并保留了牛奶中重要的营养成分。所述芦荟提取物采用如下方式制备：将芦荟叶洗净去皮后研磨成浆，去除其中的纤维素后用0.45μm的微孔过滤膜过滤即得。所述燕麦提取物采用如下方式制备：将燕麦粉碎后与甘油和去离子水混合，碎燕麦、甘油、水的质量比为1:2:20，将混合物加热到75℃并搅拌2h后，在80℃下萃取，即得燕麦提取物。所述神经酰胺起到保湿剂的作用，能维持皮脂膜的完整，同时也是细胞间脂质的主要成分，具有较强的水合作用，能够保持皮肤的滋润。所述枸杞提取物中含有30%的枸杞多糖，所述紫雏菊提取物为市售的紫锥菊茎叶提取物。
所述植物油由橄榄油、杏仁油、霍霍巴油、由麦胚或米糠中提取的角鲨烷、牛油果油、乳木果油、葡萄籽油、琼崖海棠果油、琉璃苣油、亚麻籽油组成，上述各植物油的质量比为13.5：8.6：16：4.2：13：12：13.5：6：3.9：6。
所述儿童护肤品可以为水剂、乳剂、清洁剂、肥皂、油剂、膏霜或喷雾剂中的任一种。
显然，上述实施例仅仅是为清楚地说明所作的举例，而并非对实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引伸出的显而易见的变化或变动仍处于本发明创造的保护范围之中。

Claims (10)

  1. 一种专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其特征在于，以重量份计，包括以下成分：
    牛奶提取物 50-85份；
    植物油 30-55份；
    神经酰胺 5-10份；
    芦荟提取物 10-16份；
    燕麦提取物 6-10份。
  2. 根据权利要求1所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其特征在于，所述牛奶提取物为水解牛奶蛋白、乳球蛋白、乳铁蛋白、乳清蛋白中的一种或几种；所述植物油为橄榄油、杏仁油、霍霍巴油、由麦胚或米糠中提取的角鲨烷、牛油果油、乳木果油、葡萄籽油、琼崖海棠果油、琉璃苣油、亚麻籽油中的一种或几种。
  3. 根据权利要求2所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其特征在于，所述牛奶提取物由水解牛奶蛋白、乳球蛋白、乳铁蛋白、乳清蛋白组成，上述提取物的质量比为30-50:5-10:11-18:4-9。
  4. 根据权利要求2所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其特征在于，所述植物油由橄榄油、杏仁油、霍霍巴油、由麦胚或米糠中提取的角鲨烷、牛油果油、乳木果油、葡萄籽油、琼崖海棠果油、琉璃苣油、亚麻籽油组成，上述各植物油的质量比为10-15：5-10：15-20：3-6：10-15：8-15：10-16：4-8：3-5：5-9。
  5. 根据权利要求4所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其特征在于，以重量份计，还包括枸杞提取物 3-5份；紫锥菊提取物 5-8份。
  6. 根据权利要求5所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其特征在于，所述水解牛奶蛋白的提取过程为：采用蛋白酶酶解牛奶的方法制得酶解产物，对酶解产物在40-60℃下加热后进行过滤即得。
  7. 根据权利要求6所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其特征在于，过滤后的水解牛奶蛋白的分子质量小于500道尔顿。
  8. 根据权利要求7所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其特征在于，所述芦荟提取物采用如下方式制备：将芦荟叶去皮后研磨成浆，去除其中的纤维素，并由0.45μm的过滤膜过滤即得芦荟提取物。
  9. 根据权利要求8所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其特征在于，所述燕麦提取物采用如下方式制备：将粉碎的燕麦与甘油和去离子水混合，燕麦、甘油、水的质量比为1:2:20，将混合物加热至70-80℃，搅拌1-2h后进行萃取，即得燕麦提取物；所述枸杞提取物中含有30%的枸杞多糖。
  10. 根据权利要求9所述的专为保护儿童皮脂膜、含有牛奶提取物的护肤品，其特征在于，所述护肤品可以为水剂、乳剂、清洁剂、肥皂、油剂、膏霜或喷雾剂。
PCT/CN2017/087363 2017-05-05 2017-06-07 含牛奶提取物的保护儿童皮脂膜护肤品 WO2018201549A1 (zh)

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