WO2018194111A1 - Agent d'élimination du biofilm buccal et composition buccale - Google Patents

Agent d'élimination du biofilm buccal et composition buccale Download PDF

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Publication number
WO2018194111A1
WO2018194111A1 PCT/JP2018/016062 JP2018016062W WO2018194111A1 WO 2018194111 A1 WO2018194111 A1 WO 2018194111A1 JP 2018016062 W JP2018016062 W JP 2018016062W WO 2018194111 A1 WO2018194111 A1 WO 2018194111A1
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Prior art keywords
oral
composition
biofilm
acid
oil
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PCT/JP2018/016062
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English (en)
Japanese (ja)
Inventor
勇介 川延
康彦 高橋
山本　幸司
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ライオン株式会社
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Priority to CN201880023827.0A priority Critical patent/CN110494123A/zh
Priority to JP2019513676A priority patent/JPWO2018194111A1/ja
Priority to MYPI2019005555A priority patent/MY193926A/en
Priority to KR1020197025079A priority patent/KR20190139199A/ko
Publication of WO2018194111A1 publication Critical patent/WO2018194111A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds

Definitions

  • the present invention relates to an oral biofilm remover and an oral composition containing the same.
  • Plaque control is very important. Plaque control means include suppression of plaque formation and sterilization. Among them, removal of plaque is important. In order to chemically remove plaque, not only bacterial extracellular metabolites such as glucan and protein, but also bacterial aggregates, and biofilms composed of bacterial aggregates and extracellular metabolites in combination It is very important to effectively remove the structure.
  • Patent Document 1 JP-A-2015-20970.
  • the present invention has been made in view of the above circumstances, and an object thereof is to provide a new oral biofilm remover that provides an excellent biofilm removal effect and an oral composition containing the same.
  • a polyacrylic acid salt having a relatively low molecular weight whose weight average molecular weight is not more than a specific value an anionic surfactant or an amphoteric surfactant
  • an anionic surfactant or an amphoteric surfactant it has been found that when combined with, it has an excellent oral biofilm removing action. That is, in the present invention, (a) a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less and (b) one or more selected from anionic surfactants and amphoteric surfactants are used in combination. It was found that an oral biofilm remover with excellent biofilm removal effect and good usability can be obtained.
  • the biofilm removal effect is excellent even when the amount of the component (a) is relatively small, and a good feeling of use (oral irritation) It has been found that it is also possible to impart no odor and no odor), and the present invention has been made.
  • polyacrylic acid having a weight average molecular weight of 100,000 or more, usually about 300,000 or a salt thereof is generally used.
  • a polyacrylic acid polymer having a low molecular weight molecular weight of about 4,000 to 5,500
  • the blending amount in the oral composition should be about 2.5% or more.
  • Patent Document 2 Japanese Patent Publication No. 7-29907
  • surfactants have a cleaning, penetrating, and dispersing action, and are recognized to have a slight plaque-removing action, but the action on biofilms is not sufficient.
  • a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less is obtained from (b) an anionic surfactant and an amphoteric surfactant among the surfactants.
  • a biofilm is a structure that is composed of a complex of bacterial aggregates and extracellular metabolites and is firmly constructed and exhibits high resistance.
  • the biofilm which is a highly resistant deposit was peeled off from the tooth surface and dispersed in the oral cavity, and the biofilm could be removed at a high rate.
  • the effects of the present invention are specific to the combined system of the components (a) and (b), and as shown in Comparative Examples described later, polyacrylic acid and polyacrylate having an inappropriate weight average molecular weight are used. When used in combination with component (b), the biofilm removal effect was poor.
  • Patent Document 3 Japanese Patent Application Laid-Open No. 10-287537
  • Patent Document 4 Japanese Patent Application Laid-Open No. 2002-284, 2004
  • No. -47160 is a suppression of irritation derived from phenoxyethanol or the like by polyacrylate, and sodium acrylate having a molecular weight of about 50,000 is used in the experimental example.
  • Patent Documents 3 and 4 do not mention biofilm removal. From Patent Documents 3 and 4, the improvement of the biofilm removal effect by using the components (a) and (b) of the present invention in combination cannot be predicted.
  • the present invention provides the following oral biofilm remover and oral composition.
  • A a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less;
  • B An oral biofilm remover comprising at least one selected from an anionic surfactant and an amphoteric surfactant.
  • A a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less;
  • An oral biofilm remover comprising at least one selected from an anionic surfactant and an amphoteric surfactant.
  • [3] The oral biofilm remover according to [2], wherein (a) / (b) is 0.02 to 1 as a mass ratio.
  • the anionic surfactant is selected from alkyl sulfates, acyl amino acid salts and acyl taurine salts having an alkyl group having 12 to 14 carbon atoms
  • the amphoteric surfactant is an acylaminoacetic acid having an acyl group having 12 to 14 carbon atoms.
  • the oral biofilm remover according to any one of [1] to [3], which is selected from betaine and fatty acid amidopropyl betaine.
  • composition for oral cavity according to [5] or [6] wherein the content of component (a) is 0.01 to 2% by mass and the content of component (b) is 0.5 to 3% by mass.
  • an oral biofilm remover that has an excellent biofilm removal effect and has a good feeling of use, and an oral composition containing the same.
  • the oral biofilm remover and oral composition of the present invention are effective for the prevention or suppression of periodontal diseases.
  • the oral biofilm remover of the present invention is selected from (a) a polyacrylate having a weight average molecular weight of 1,000 or more and 20,000 or less, and (b) an anionic surfactant and an amphoteric surfactant. More than seeds are active ingredients.
  • the polyacrylate of component (a) has a weight average molecular weight (Mw) of 1,000 or more and 20,000 or less.
  • Mw weight average molecular weight
  • the weight average molecular weight is 1,000 or more, and is 20,000 or less, preferably 10,000 or less.
  • the weight average molecular weight is less than 1,000, the biofilm removal effect is poor.
  • it exceeds 20,000 the effect of removing the biofilm is lowered and a sufficient effect cannot be obtained.
  • the weight average molecular weight was measured by GPC (gel permeation chromatography) under the method and measurement conditions described in Japanese Patent No. 5740859. Specifically, it is shown below.
  • the weight average molecular weight is a value measured using a gel permeation chromatograph / multi-angle laser light scattering detector (GPC-MALLS), and the conditions are as follows.
  • Mobile phase 0.3M NaClO 4 NaN 3 aqueous solution column: 2
  • the polyacrylate is preferably a linear polyacrylate from the viewpoint of the biofilm removal effect.
  • the salt is preferably a monovalent salt, more preferably an alkali metal salt or an ammonium salt, still more preferably an alkali metal salt, especially a sodium salt.
  • a biofilm removal rate is bad, and oral irritation
  • a commercial item can be used as such a polyacrylate.
  • the component (b) is one or more selected from the anionic surfactant (b1) and the amphoteric surfactant (b2), and even if the component (b1) or (b2) is used, (b1) and Although the component (b2) may be used, it is preferable to include at least an anionic surfactant (b1) particularly from the viewpoint of feeling in use, and only the component (b1) is used or (b1) and (b2) It is preferable to use the components in combination.
  • anionic surfactant (b1) examples include alkyl sulfates, acylamino acid salts, and acyl taurine salts having an alkyl group of preferably 12 to 14, particularly 12 carbon atoms.
  • the acyl groups of the acyl amino acid salt and the acyl taurine salt each preferably have 12 to 14 carbon atoms, more preferably 12.
  • Specific examples of the alkyl sulfate include lauryl sulfate and myristyl sulfate.
  • acyl amino acid salts include acyl glutamates such as lauroyl glutamate and myristoyl glutamate, and acyl sarcosine salts such as lauroyl sarcosine salt.
  • acyl taurine salt examples include lauroylmethyl taurine salt.
  • the salt is preferably an alkali metal salt such as a sodium salt or a potassium salt. These can be used alone or in combination of two or more, and alkyl sulfates, acyl sarcosine salts, and acyl taurine salts are particularly preferable.
  • anionic surfactants having a hydrocarbon group having 12 carbon atoms (lauryl group) are preferable, and alkyl sulfates (sodium salts) are particularly preferable because they are superior in taste to other surfactants. .
  • the amphoteric surfactant (b2) is preferably a betaine type, and examples thereof include acylaminoacetic acid betaines having a C 12-14 acyl group and fatty acid amidopropyl betaines.
  • the acylaminoacetic acid betaine preferably has an acyl group having 12 to 14 carbon atoms, and examples include lauroyldimethylaminoacetic acid betaine.
  • the fatty acid amidopropyl betaine includes coconut oil fatty acid amidopropyl betaine. These may be used singly or in combination of two or more, and acylaminoacetic acid betaine is particularly preferred. Among them, those having a hydrocarbon group having 12 carbon atoms (lauryl group) are preferable, and lauryldimethylaminoacetic acid betaine is more preferable.
  • (A) / (b) indicating the quantitative ratio of the component (a) to the component (b) is preferably 0.005 to 2, more preferably 0.005 to 1, and still more preferably 0.02 as a mass ratio. To 1, particularly preferably 0.03 to 0.5.
  • the biofilm removing effect is more excellent, and the odor and taste are better and the feeling of use is further improved.
  • it is 0.005 or more the biofilm removing effect is further improved, and when it is 2 or less, it is possible to sufficiently maintain a good feeling of smell and taste.
  • the oral biofilm remover of the present invention can be obtained by combining the components (a) and (b) as active ingredients. Moreover, although it can be used as an oral biofilm remover consisting of only the above active ingredient, it may further contain other optional ingredients known for oral use as necessary, in which case the optional ingredients are the effects of the present invention. Can be blended within a range not hindering
  • the oral composition of the present invention contains the components (a) and (b) as active ingredients.
  • the composition for oral cavity is specifically a paste, gel or liquid dentifrice composition (toothpaste, gel dentifrice, liquid dentifrice, liquid dentifrice, etc.), mouthwash, mouse spray, coating agent, patch Can be prepared. Of these, toothpaste is preferred.
  • the components (a) and (b), which are effective components for removing the oral biofilm can be defined by the above-mentioned specific ratio.
  • the blending amounts of the components (a) and (b) are preferably in the ranges described below, and it is preferable to use both components at a concentration satisfying these.
  • the blending amount of component (a) is preferably 0.01 to 2% (mass%, the same applies hereinafter), more preferably 0.01 to 1%, still more preferably 0.05 to 0.5% of the entire composition. It is. If the content is 0.01% or more, a sufficient biofilm removal effect can be obtained. If it is 2% or less, the odor and taste can be maintained satisfactorily and sufficiently. If too much is blended, the odor and taste may deteriorate and the usability may be inferior.
  • the blending amount of component (b) is preferably 0.5 to 3% of the total composition, more preferably 0.5 to 2%, and still more preferably 1.0 to 2.0%.
  • the content is 0.5% or more, a sufficient biofilm removal effect can be obtained. If it is 3% or less, oral irritation can be sufficiently suppressed, and the odor and taste can be maintained satisfactorily. If too much is added, the oral irritation becomes stronger, the odor and taste become worse, and the usability may be inferior.
  • a known component according to the dosage form can be further blended as necessary.
  • the optional component is preferably added as long as the effects of the present invention are not hindered.
  • dentifrice compositions include abrasives, binders, thickeners, nonionic surfactants and cationic surfactants as surfactants, as well as sweeteners, preservatives, active ingredients, and pigments. Perfumes can be blended, and these components and water can be mixed and manufactured.
  • dibasic calcium hydrogen phosphate, anhydrous and dihydrate, tricalcium phosphate, primary calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, anhydrous silicic acid, aluminum silicate, insoluble Sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, magnesium sulfate, bentonite, zirconium silicate, polymethyl metaphosphate, and other synthetic resins can be blended (the blending amount is usually 5 to 60%, 10 for toothpaste). ⁇ 55%).
  • paste-like dentifrice compositions such as toothpaste, alginic acid derivatives such as sodium alginate and propylene glycol alginate as a binder, gums such as xanthan gum, tragacanth gum, gela gum, karaya gum, gum arabic, carrageenan, carboxymethylcellulose
  • gums such as xanthan gum, tragacanth gum, gela gum, karaya gum, gum arabic, carrageenan, carboxymethylcellulose
  • Cellulose derivatives such as sodium, methylcellulose, hydroxyethylcellulose, sodium carboxymethylhydroxyethylcellulose
  • organic binders such as polyvinyl alcohol, carboxyvinyl polymer, and polyvinylpyrrolidone
  • inorganic binders such as silica gel, aluminum silica gel, bee gum, and laponite can be blended. (The amount is usually 0.3 to 10%).
  • sugar alcohols such as sorbitol, maltitol, lactitol, erythritol, and polyhydric alcohols such as propylene glycol can be blended as a thickening agent.
  • sorbitol maltitol
  • lactitol lactitol
  • erythritol polyhydric alcohols
  • propylene glycol can be blended as a thickening agent.
  • two or more kinds can be blended (the blending amount is usually 5 to 70%).
  • Nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters; sugar alcohol fatty acid esters such as maltitol fatty acid esters; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate; polyoxyethylene cured castor Polyoxyethylene fatty acid esters such as oil; fatty acid diethanolamides such as lauric acid mono- or diethanolamide; polyoxyethylene higher alcohol ethers can be blended.
  • polyoxyethylene fatty acid ester particularly polyoxyethylene hydrogenated castor oil having an added mole number of ethylene oxide (EO, the same applies hereinafter) of 20 to 100, particularly 20 to 80, is effective in removing biofilms. More preferred.
  • the cationic surfactant examples include alkylammonium salts such as distearylmethylammonium chloride, alkylbenzylammonium salts such as stearyldimethylbenzylammonium chloride, and the like.
  • the total amount of the nonionic surfactant and the cationic surfactant is preferably 0.01 to 10%.
  • the odor and taste may be deteriorated depending on the amount added, but when the nonionic surfactant is added together with the component (b) Thus, the biofilm removal effect is further improved without deteriorating the feeling of use.
  • a nonionic surfactant particularly polyoxyethylene hydrogenated castor oil
  • Sweetening agents include sodium saccharin, stevioside, dipotassium glycyrrhizinate, perilartin, thaumatin, neohesperidyl dihydrochalcone, and aspartylphenylalanine methyl ester.
  • Examples of the preservative include p-hydroxybenzoate ester and sodium benzoate.
  • active ingredients enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, SOD (superoxide dismutase); alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate; Fluorides such as sodium fluoride and stannous fluoride; tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyl allantoin, dihydrocholestanol, glycyrrhizic acid, glycyrrhetinic acid, glycerophosphate, chlorophyll, sodium chloride, xylitol, zinc chloride, Examples include water-soluble inorganic phosphates and vitamins such as vitamin A, vitamin B group, vitamin C, and vitamin E. These active ingredients can be used alone or in combination of two or more, and can be blended in an effective amount as long as the effects of the present invention are not
  • Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint Natural fragrances such as absolute rose and orange flower, and fragrances that have been processed (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), and Menthol, Carvone, Anethole, Methyl salicylate, Cinnami Cualdehyde, 3-l-menthoxypropane-1,2-diol, linalool, linalyl acetate,
  • fragrance material can be used, and known fragrance materials used in oral compositions can be used. It is not limited to. Further, the above fragrance material is preferably used in an amount of 0.000001 to 1% of the entire composition. As the flavoring fragrance using the fragrance material, it is preferable to use 0.001 to 2.0% in the preparation composition.
  • the pH (25 ° C.) of the oral composition is preferably 5 to 9, more preferably 6 to 8. If the pH is too low, there is a risk of oral irritation and demineralization of enamel and dentin. If the pH is too high, oral irritation and a decrease in formulation stability may occur.
  • a pH adjuster may be added.
  • inorganic acids, organic acids, and salts thereof can be used.
  • examples include sodium hydrogen, sodium phosphate, and sodium dihydrogen phosphate.
  • the oral composition of the present invention can be used by placing it in a predetermined container such as an aluminum tube, a laminated tube obtained by laminating both surfaces of an aluminum foil with plastic, a plastic tube, a bottle-shaped container, an aerosol container or the like.
  • a predetermined container such as an aluminum tube, a laminated tube obtained by laminating both surfaces of an aluminum foil with plastic, a plastic tube, a bottle-shaped container, an aerosol container or the like.
  • % means “% by mass” unless otherwise specified.
  • the weight average molecular weight is a value measured using a gel permeation chromatograph / multi-angle laser light scattering detector (GPC-MALLS), and the conditions are as follows. Mobile phase: 0.3M NaClO 4 NaN 3 aqueous solution column: 2 TSKgel ⁇ -M Precolumn: TSKguardcolumn ⁇ Standard substance: polyethylene glycol The pH of the composition is a value at 25 ° C.
  • Dentifrice compositions (toothpaste) having the compositions shown in Tables 1 to 3 were prepared by the following method, filled in containers (aluminum laminate tubes), and evaluated by the following methods. The results are shown in the table.
  • ⁇ Preparation method> (1) The component (a), other water-soluble components, and a viscosity modifier were mixed and dissolved at room temperature in purified water (mixture X). (2) A binder was dispersed in propylene glycol at room temperature (mixture Y), and the mixture Y was added and mixed into the stirring mixture X to prepare a mixture Z. (3) In the mixture Z, a fragrance
  • ⁇ Evaluation method of biofilm removal effect (1) Method for producing model biofilm
  • the bacteria used for producing the model biofilm were purchased from American Type Culture Collection (ATCC) and precultured by the following method. Actinomyces viscosus ATCC 43146, Fusobacterium nucleatum ATCC10953, Porphyromonas gingivalis, ATCC 33727 Todd Hewitt broth (manufactured by Becton and Dickinson) medium (THBHM) and Baylonella parvula ATCC 17745 is Todd Hewitt broth containing 1.26% sodium lactate (Sigma) (Becton and Dickins They were cultured by n Co., Ltd.) culture [THBL]. The culture was anaerobic culture overnight at 37 ° C.
  • the culture solution discharged from the culture tank was continuously supplied to another culture tank in which the liquid volume was kept at 300 mL.
  • a hydroxyapatite plate (manufactured by PENTAX) having a diameter of 7 mm was attached to the turntable (rotated at about 80 rpm) in the culture tank as a biofilm adhesion carrier.
  • the culture by the above method was carried out continuously for 10 days, and a biofilm was formed on the hydroxyapatite plate.
  • the biofilm-formed hydroxyapatite plate was washed twice with 5 mL of phosphate buffered saline * 2 (hereinafter referred to as PBS) to obtain a model biofilm.
  • PBS phosphate buffered saline * 2
  • the cells were washed 6 times with 1 mL of PBS (manufactured by Wako Pure Chemical Industries, Ltd.), and remained in the test tube (diameter 13 mm ⁇ 100 mm) to which 2 mL of the same buffer was added by sonication (200 ⁇ A, 10 seconds).
  • the film was forced to disperse.
  • the turbidity (OD) at a wavelength of 550 nm of this dispersion was measured, and the residual amount of the biofilm was measured.
  • the biofilm removal effect of the test composition was determined by calculating the removal rate relative to the control by the following formula, and determining the oral biofilm removal effect from this removal rate according to the following criteria.
  • Biofilm removal rate (%) ⁇ (Turbidity of control-turbidity of treated product of test composition) / turbidity of control ⁇ ⁇ 100 Criteria for Biofilm Removal Effect ⁇ : Biofilm removal rate is 90% or more ⁇ : Biofilm removal rate is 70% or more and less than 90% ⁇ : Biofilm removal rate is 50% or more and less than 70% ⁇ : Biofilm removal rate is Less than 50%
  • Evaluation criteria for oral irritation 4 points I do not feel irritation in the oral cavity 3 points: I feel a little irritation in the oral cavity but no problem 2 points: I feel irritation in the oral cavity 1 point: I feel very irritation in the oral cavity Judgment criteria for oral irritation ⁇ : Average score of 3.0 or more ⁇ : Average score of 2.5 or more and less than 3.0 ⁇ : Average score of 1.5 or more and less than 2.5 ⁇ : Average score of 1.5 Less than the point Evaluation criteria for odor 4 points: Feeling unpleasant odor in the oral cavity 3 points: Feeling an unpleasant odor somewhat in the oral cavity but no problem 2 points: Feeling an unpleasant odor in the oral cavity 1 point: In the oral cavity Unpleasant odor is strongly felt Odor judgment criteria ⁇ : Average score of 3.5 points or more ⁇ : Average score of 3.0 points or more and less than 3.5 points ⁇ : Average score of 2.0 points or more and less than 3.0 points ⁇ : Average point less than 2.0

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  • Cosmetics (AREA)

Abstract

L'invention concerne un agent d'élimination du biofilm buccal, comprenant (a) un sel d'acide polyacrylique de poids moléculaire moyen compris entre 1 000 et 20 000, inclus, et (b) au moins un constituant sélectionné parmi un tensioactif anionique et un tensioactif amphotère, un rapport massique (a)/(b) compris entre 0,005 et 2 étant préféré. L'invention concerne également une composition buccale contenant les constituants (a) et (b), un rapport massique (a)/(b) compris entre 0,005 et 2 étant préféré. Selon la présente invention, il devient possible de produire : un agent d'élimination du biofilm buccal qui présente un excellent effet d'élimination du biofilm et offre une sensation de confort lors de l'utilisation ; et une composition buccale contenant l'agent d'élimination du biofilm buccal.
PCT/JP2018/016062 2017-04-21 2018-04-19 Agent d'élimination du biofilm buccal et composition buccale WO2018194111A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201880023827.0A CN110494123A (zh) 2017-04-21 2018-04-19 口腔生物膜去除剂和口腔用组合物
JP2019513676A JPWO2018194111A1 (ja) 2017-04-21 2018-04-19 口腔バイオフィルム除去剤及び口腔用組成物
MYPI2019005555A MY193926A (en) 2017-04-21 2018-04-19 Oral biofilm removing agent and oral composition
KR1020197025079A KR20190139199A (ko) 2017-04-21 2018-04-19 구강 바이오필름 제거제 및 구강용 조성물

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JP2017084672 2017-04-21
JP2017-084672 2017-04-21

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WO2018194111A1 true WO2018194111A1 (fr) 2018-10-25

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KR (1) KR20190139199A (fr)
CN (1) CN110494123A (fr)
MY (1) MY193926A (fr)
WO (1) WO2018194111A1 (fr)

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WO2019107335A1 (fr) * 2017-11-30 2019-06-06 ライオン株式会社 Inhibiteur de formation de biofilm buccal et composition à usage oral
WO2019107332A1 (fr) * 2017-11-30 2019-06-06 ライオン株式会社 Agent d'élimination de taches buccales, agent inhibiteur de formation de taches buccales, et composition buccale
WO2020137417A1 (fr) * 2018-12-26 2020-07-02 ライオン株式会社 Composition orale
JP2020100596A (ja) * 2018-12-25 2020-07-02 ライオン株式会社 口腔バイオフィルム除去剤及び口腔用組成物
JP2020143023A (ja) * 2019-03-08 2020-09-10 ライオン株式会社 口腔用組成物
JP2021098678A (ja) * 2019-12-24 2021-07-01 ライオン株式会社 口腔用組成物

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Publication number Priority date Publication date Assignee Title
WO2019107335A1 (fr) * 2017-11-30 2019-06-06 ライオン株式会社 Inhibiteur de formation de biofilm buccal et composition à usage oral
WO2019107332A1 (fr) * 2017-11-30 2019-06-06 ライオン株式会社 Agent d'élimination de taches buccales, agent inhibiteur de formation de taches buccales, et composition buccale
WO2019107340A1 (fr) * 2017-11-30 2019-06-06 ライオン株式会社 Composition pour utilisation par voie orale
JP2020100596A (ja) * 2018-12-25 2020-07-02 ライオン株式会社 口腔バイオフィルム除去剤及び口腔用組成物
CN113038925A (zh) * 2018-12-26 2021-06-25 狮王株式会社 口腔用组合物
WO2020137417A1 (fr) * 2018-12-26 2020-07-02 ライオン株式会社 Composition orale
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CN113038925B (zh) * 2018-12-26 2023-10-20 狮王株式会社 口腔用组合物
JP2020143023A (ja) * 2019-03-08 2020-09-10 ライオン株式会社 口腔用組成物
JP7120087B2 (ja) 2019-03-08 2022-08-17 ライオン株式会社 口腔用組成物
JP2021098678A (ja) * 2019-12-24 2021-07-01 ライオン株式会社 口腔用組成物
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JP7342688B2 (ja) 2019-12-24 2023-09-12 ライオン株式会社 口腔用組成物

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KR20190139199A (ko) 2019-12-17
MY193926A (en) 2022-11-01
CN110494123A (zh) 2019-11-22

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