WO2018190301A1 - 角栓を除去する方法 - Google Patents

角栓を除去する方法 Download PDF

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Publication number
WO2018190301A1
WO2018190301A1 PCT/JP2018/014941 JP2018014941W WO2018190301A1 WO 2018190301 A1 WO2018190301 A1 WO 2018190301A1 JP 2018014941 W JP2018014941 W JP 2018014941W WO 2018190301 A1 WO2018190301 A1 WO 2018190301A1
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mass
component
amino
composition
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PCT/JP2018/014941
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English (en)
French (fr)
Japanese (ja)
Inventor
敏明 尾沢
隆也 坂井
真理子 三好
大輔 古川
彩 白井
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Kao Corp
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Kao Corp
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Priority to JP2018522155A priority Critical patent/JP6606284B2/ja
Priority to CN201880024002.0A priority patent/CN110494120B/zh
Priority to US16/604,019 priority patent/US11406576B2/en
Priority to EP18784620.9A priority patent/EP3610849B1/en
Publication of WO2018190301A1 publication Critical patent/WO2018190301A1/ja
Anticipated expiration legal-status Critical
Priority to US17/809,661 priority patent/US11975086B2/en
Ceased legal-status Critical Current

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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Definitions

  • the present invention relates to a method for removing horn plugs using a composition containing 2-amino-2-hydroxymethyl-1,3-propanediol and the like.
  • a horn plug is a substance that is found in the pores at sites where the amount of sebum is secreted, such as around the nose, and plugs the pores in the form of plugs. If the keratin plug is left without being removed, the skin becomes rough, and the keratin plug physically expands the pores, so that the pore opening tends to be large, and the surface of the keratin plug is oxidized. There is also a risk that the darkness due to the above may occur and the aesthetics may be impaired. In addition, they tend to cause acne and other skin problems such as rashes and breakouts. For these reasons, horn plugs have become a source of trouble for many women as one of the causes of conspicuous pores. Therefore, various techniques for removing such horn plugs have been developed.
  • Patent Document 1 discloses a skin cleanser composition containing an organic acid such as lactic acid and an N-acyl taurine-type anionic surfactant and having a pH of 3 to 5, and exhibits good foaming. Etc., the effect of removing plugs can be exhibited.
  • Patent Document 2 discloses a cleaning composition containing a specific nonionic surfactant, an oil having a viscosity at 30 ° C. of 15 mPa ⁇ s or less, a water-soluble polymer, and the like.
  • Patent Document 4 discloses a sheet-like pack comprising a multilayer moisture-permeable holder and a cosmetic containing a polymer compound having a halophilic group such as a carboxyl group.
  • Patent Document 1 JP-A-2015-113307 (Patent Document 2) JP-A-2011-12252 (Patent Document 3) JP-A-2007-230929 (Patent Document 4) JP-A-11-12127
  • the present invention relates to 2-amino-2-hydroxymethyl-1,3-propanediol (X1), 2-amino-2-methyl-1-propanol (X2), and 2-amino-2-methyl-1,3
  • the present invention relates to a method for removing horn plugs using a composition containing one or more (X) selected from propanediol (X3).
  • the present invention also provides 2-amino-2-hydroxymethyl-1,3-propanediol (X1), 2-amino-2-methyl-1-propanol (X2), and 2-amino-2-methyl-1 , 3-propanediol (X3)
  • the present invention relates to a horn plug removing composition containing one or more selected from (X).
  • the sheet pack described in Patent Document 4 that exhibits the effect of physically removing square plugs can directly remove the square plugs and can achieve a remarkable reduction in clogging of pores.
  • the physical removal means may damage the skin
  • the emergence of a horn plug removal technique with reduced pain and irritation to the skin is desired. Therefore, the emergence of a new technique that can sufficiently exhibit an excellent effect of removing horn plugs without imposing a burden such as pain or irritation on the skin is desired.
  • the present inventors have used a composition containing a specific component such as 2-amino-2-hydroxymethyl-1,3-propanediol, The present inventors have found a method that can more effectively remove horn plugs without causing excessive pain or irritation to the skin, and have completed the present invention.
  • the present invention it is possible to effectively remove horn plugs without imposing a burden on the skin, and to effectively prevent clogging of pores by significantly suppressing clogging of pores and opening of pores. it can.
  • the skin after removal of the horn plug can realize bright and beautiful skin that is fine and flexible and has no darkening.
  • the brightness of the skin can be increased to reduce skin dullness, and the effect of promoting the penetration of the drug from the pores and enhancing the action of the drug can be expected.
  • the horn plugs be effectively removed, but also protein aggregation can be suppressed, so that it is useful as a skin cosmetic for washing pores, and a protein aggregation inhibitor Or as a skin external preparation for acne suppression.
  • FIG. 1 is a graph showing the relationship between the average amount of change in the average brightness value of the internally scattered light and the number of consecutive days calculated on the 7th, 14th and 21st days calculated in Example 2.
  • plug means a substance that is physiologically formed in the pores of a human skin and closes the pores in the form of plugs.
  • the main components of such horn plugs are proteins derived from the stratum corneum and hair follicle, and these main components include proteins derived from acne bacteria and Staphylococcus aureus, proteins derived from intracellular organelles such as lysosomes, and triglycerides.
  • the horn plug is formed of a substance mixed with free fatty acid, lipid containing lipid peroxide, or the like.
  • the method for removing horn plugs of the present invention comprises 2-amino-2-hydroxymethyl-1,3-propanediol (X1), 2-amino-2-methyl-1-propanol (X2), and 2-amino-
  • a composition containing one or more (X) selected from 2-methyl-1,3-propanediol (X3) (hereinafter also referred to as component (X)) is used.
  • the above composition contains, as component (X), 2-amino-2-hydroxymethyl-1,3-propanediol (X1), 2-amino-2-methyl-1-propanol (X2), and 2-amino- It suffices to contain one or more selected from 2-methyl-1,3-propanediol (X3).
  • composition containing these components (X) may be used alone or in combination of two or more.
  • the composition containing the component (X) quickly penetrates into the horn plugs, effectively removing the lipids that form the horn plugs. Can be eluted.
  • proteins such as stratum corneum easily aggregate and are difficult to remove with a cleaning agent or the like, but by applying a composition containing component (X) to the skin, protein aggregation is also suppressed at the same time. Therefore, even a square plug containing protein can be effectively removed.
  • the corneal plug when water is washed away after application of the composition, water easily penetrates into the keratin plug, so that the corneal plug further disintegrates due to the penetration of water, and it is possible to cleanly wash away proteins and lipids.
  • the included square plug can be effectively removed from the pores.
  • the skin around the pores after the removal of the horn plug can be softened while exhibiting an excellent effect of removing the horn plug, and the skin can be soft, soft, bright and beautiful.
  • the 2-amino-2-hydroxymethyl-1,3-propanediol of the component (X1) is specifically represented by the following structural formula (x1), “tris (hydroxymethyl) aminomethane”, or It is a component also called “Tris”.
  • the component (X1) has a molecular weight of 121.14, a melting point of 169 to 173 ° C., and a boiling point of 219 to 220 ° C. (10 mmHg). In addition, it is a weakly basic component having a pKa of 8.03 at 25 ° C. and easily soluble in water.
  • the component (X2), 2-amino-2-methyl-1-propanol, is specifically a component represented by the following structural formula (x2) and also simply referred to as “AMP”.
  • the component (X2) has a molecular weight of 89.14, a melting point of 30 to 31 ° C., and a boiling point of 165.5 ° C. (10 mmHg). Moreover, pKa in 25 degreeC is 9.72, and is a component which is easy to melt
  • the component (X3), 2-amino-2-methyl-1,3-propanediol, is specifically a component represented by the following structural formula (x3) and also simply referred to as “AMPD”.
  • the component (X3) has a molecular weight of 105.14, a melting point of 107 to 112 ° C., and a boiling point of 151 ° C. (10 mmHg). Moreover, pKa in 25 degreeC is 8.76, and is a component which is easy to melt
  • 2-amino-2-hydroxymethyl-1,3-propanediol (X1) is contained.
  • 2-amino-2-hydroxymethyl-1,3-propanediol (X1) and 2-amino-2-methyl-1-propanol (X2 And 2-amino-2-methyl-1,3-propanediol (X3) preferably 2-amino-2-hydroxymethyl-1,3-propanediol (X1), And 2-amino-2-methyl-1,3-propanediol (X3).
  • mass ratio ((X3) / ((X1) + (X2)) of content of component (X3) and total content of component (X1) and component (X2) ) Is preferably 0.001 or more, more preferably 0.05 or more, and still more preferably 0.08 or more, from the viewpoint of enhancing the effect of removing plugs while suppressing the burden on the skin. More preferably, it is 0.10 or more.
  • the mass ratio ((X3) / ((X1) + (X2))) of the content of component (X3) and the total content of component (X1) and component (X2) suppresses the burden on the skin.
  • the mass ratio ((X3) / ((X1) + (X2))) between the content of component (X3) and the total content of component (X1) and component (X2) is preferably 0.001 to 100, more preferably 0.05 to 50, still more preferably 0.08 to 20, and still more preferably 0.10 to 10.
  • the total content of component (X) is preferably 0.08% by mass or more in the composition to be used, and more preferably 0.8% by mass, from the viewpoint of satisfactorily combining the effect of removing horn plugs and the effect of inhibiting protein aggregation.
  • the total content of component (X) is preferably 35% by mass or less, more preferably 30% by mass in the composition to be used, from the viewpoint of satisfactorily combining the effect of removing horn plugs and the effect of suppressing protein aggregation.
  • % Or less more preferably 25% by mass or less, more preferably 20% by mass or less, further preferably 15% by mass or less, further preferably 12% by mass or less, and further preferably 11% by mass.
  • % Or less and more preferably 10% by mass or less.
  • the total content of component (X) is preferably 0.08 to 35% by mass in the composition to be used, more preferably 0.10 to 30% by mass, and still more preferably 0.5 to 25% by mass, more preferably 0.8 to 20% by mass, further preferably 1.0 to 20% by mass, further preferably 2 to 15% by mass, and further preferably 3 to 12% by mass. %, More preferably 4 to 11% by mass, and further preferably 5 to 10% by mass.
  • composition used in the present invention is combined with the component (X), and from the viewpoint of securing a high effect of removing keratin plugs and from the viewpoint of further softening the skin, a basic substance (Y) other than the component (X) (hereinafter referred to as the component (X)) , Component (Y)).
  • the basic substance other than the component (X) means a compound other than the component (X) and showing basicity. Specifically, it is dissolved in water at 25 ° C. and has a concentration of 1% by mass. When adjusted to an aqueous solution, the aqueous solution indicates a compound having a value of pH 8 or higher. More specifically, the component (Y) includes monoethanolamine, triethanolamine, methylamine, ethylamine, trimethylamine, triethylamine, ethylenediamine, tetramethylethylenediamine, hexamethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepenta.
  • Chain or cyclic aliphatic amines such as min, pentaethylenehexamine and morpholine; basic amino acids such as arginine and lysine; dipotassium hydrogen phosphate, disodium hydrogen phosphate, trisodium citrate, sodium bicarbonate, sodium acetate
  • Inorganic salts consisting of strong bases such as lithium carbonate, sodium carbonate, potassium carbonate, potassium bicarbonate, potassium acetate and weak acids such as carbonic acid, bicarbonate, acetic acid, phosphoric acid, citric acid, and fatty acids
  • aniline One or more selected from aromatic amines such as pyridine and the like.
  • arginine monoethanolamine, triethanol More preferably, one or more selected from amines and morpholines are included, more preferably one or two selected from arginine and triethanolamino, and even more preferably arginine.
  • the total content of the component (Y) is preferably 0.01% by mass or more in the composition to be used, and more preferably from the viewpoint of combining the effect of removing keratin plugs and the effect of softening the skin. It is 05 mass% or more, More preferably, it is 0.10 mass% or more. In addition, the total content of component (Y) is preferably 15% by mass or less in the composition to be used from the viewpoint of preventing irritation to the skin from increasing and improving the effect of removing horn plugs. Preferably it is 12 mass% or less, More preferably, it is 10 mass% or less. The total content of component (Y) is preferably 0.01 to 15% by mass, more preferably 0.05 to 12% by mass, and still more preferably 0.10 to 0.1% by mass in the composition to be used. 10% by mass.
  • the total content of the component (X) and the component (Y) is preferably 50% by mass or less, more preferably 32% by mass or less, in the composition to be used from the viewpoint of preventing irritation to the skin from increasing. More preferably, it is 25 mass% or less, More preferably, it is 20 mass% or less, More preferably, it is 15 mass% or less, More preferably, it is 12 mass% or less.
  • the total content of the component (X) and the component (Y) is preferably 0.09% by mass or more in the composition to be used from the viewpoint of satisfactorily combining the effect of removing the plugs and the effect of suppressing the aggregation of the protein.
  • the total content of the component (X) and the component (Y) is preferably 0.09 to 50% by mass, more preferably 0.15 to 32% by mass, and still more preferably in the composition to be used. Is 0.50 to 25% by mass, 1.0 to 20% by mass, more preferably 2 to 15% by mass, further preferably 3 to 12% by mass, and further preferably 5 to 12% by mass. %, More preferably more than 5 mass% and 12 mass% or less.
  • the mass ratio ((X) / (Y)) of the content of the component (X) and the content of the component (Y) is the effect of removing the horn plug while suppressing the burden on the skin. From the viewpoint of enhancing the amount, it is preferably 0.001 or more, more preferably 0.005 or more, still more preferably 0.008 or more, and further preferably 0.010 or more. Moreover, in the composition used by this invention, mass ratio ((X) / (Y)) with content of the component (X) with respect to content of a component (Y) is suppressing the burden to skin.
  • the mass ratio ((X) / (Y)) of the content of component (X) to the content of component (Y) is preferably 0.001 to 200, More preferably, it is 0.005 to 150, still more preferably 0.008 to 120, and still more preferably 0.01 to 100.
  • the said component (X) exists in a composition with a free form instead of a salt form from a viewpoint of improving a square plug detergency. That is, an acidic component such as unneutralized fatty acid and component (X) do not form a salt such as a fatty acid salt, and at least a part of component (X) is free and component (X) remains alone. It is preferably present in the composition.
  • the mass ratio of the content of the component (X) present in the free form and the content of the component (X) is preferably 0.6 or more, more preferably 0.8 or more, further preferably 0.9 or more, and further preferably 1.0.
  • the component (Y) is preferably present in the composition in a free form, not in a salt form, from the viewpoint of improving corn plug cleaning power and skin flexibility, for example, as an unneutralized fatty acid.
  • the component (Y) is free and the component (Y) is present alone in the composition without forming a salt such as a fatty acid salt between the acidic component and the component (Y).
  • the mass ratio between the content of the component (Y) in the free form and the content of the component (Y) (content of the component (Y) in the free state / content of the component (Y)) is preferably 0.6 or more, more preferably 0.8 or more, further preferably 0.9 or more, and further preferably 1.0.
  • composition used in the present invention may further contain an anionic surfactant (A) from the viewpoint of improving foamability in addition to the above components.
  • an anionic surfactant (A) an anionic surfactant having a carboxylic acid group and / or an anionic interface having a sulfonic acid group or a sulfate ester group It is preferable to contain an activator (A2).
  • Carboxylic acid group means to include a carboxylic acid residue, and examples of the anionic surfactant having a carboxylic acid group of component (A1) include fatty acids or salts thereof, ether carboxylic acids or salts thereof, One or more selected from N-acylamino acid salts are preferred, and ether carboxylic acids or salts thereof are more preferred.
  • the fatty acid or salt thereof that can be used as the component (A1) is a linear or branched alkyl group having 10 to 22 carbon atoms from the viewpoint of exhibiting good foaming properties and further enhancing the effect of removing horn plugs.
  • a fatty acid having a straight chain or branched chain alkyl group having 10 to 18 carbon atoms or a salt thereof is more preferable, and a fatty acid having a straight chain alkyl group having 12 to 16 carbon atoms or a salt thereof Is more preferable, and a fatty acid having a linear alkyl group having 12 to 14 carbon atoms or a salt thereof is more preferable.
  • Specific examples include one or more selected from laurate, myristate, palmitate, stearate, behenate, and salts thereof.
  • 2 types are included.
  • the salt constituting the fatty acid salt of component (A1) preferably contains one or more selected from alkali metals and ammonium, and includes one or more selected from alkali metals. Is more preferable, and it is more preferable that a sodium salt is included.
  • a fatty acid salt formed by an unneutralized fatty acid and a neutralizing agent may be contained.
  • the neutralization rate of the fatty acid is preferably 50 to 100%, more preferably 70 to 100%, and further preferably 90 to 100%, from the viewpoint of improving the foam amount and foamability. Preferably, it is 100%.
  • the neutralizing agent is preferably one or two selected from potassium hydroxide and sodium hydroxide.
  • Examples of the ether carboxylic acid or a salt thereof that can be used as the component (A1) include an ether carboxylic acid represented by the following general formula (1) or a salt thereof.
  • R 1 O (CH 2 CH 2 O) m CH 2 COOM 1 (1) (In the formula (1), R 1 represents an alkyl or alkenyl group having 10 to 22 carbon atoms, m represents an average number of 0.5 to 10, and M 1 represents a hydrogen atom, an alkali metal, an alkaline earth (Indicates metal, ammonium or organic ammonium.)
  • R 1 is preferably an alkyl group having 12 to 16 carbon atoms from the viewpoint of exhibiting good foaming properties and further enhancing the effect of removing the plugs, and has 12 to 14 carbon atoms.
  • the average added mole number m of ethylene oxide is preferably 2 to 5.
  • M 1 includes a hydrogen atom; alkali metals such as sodium and potassium; alkaline earth metals such as calcium and magnesium; ammonium; ammonium derived from alkanolamines such as monoethanolamine, diethanolamine and triethanolamine; arginine and lysine Examples include ammonium derived from basic amino acids. Among these, from the same viewpoint as described above, one or more selected from sodium, potassium, triethanolamine and arginine are preferable, and one or two selected from sodium and potassium are more preferable.
  • ether carboxylic acids or salts thereof include polyoxyethylene lauryl ether carboxylate, polyoxyethylene myristyl ether carboxylate, and polyoxyethylene palmityl ether carboxylate from the same viewpoint as described above. It is preferable to include one or more selected from the group consisting of polyoxyethylene lauryl ether carboxylate and polyoxyethylene myristyl ether carboxylate. More preferably, it contains oxyethylene lauryl ether carboxylate.
  • AKYPO RLM 45CA made by Kao Corporation
  • AKYPO LM 26C made by Kao Corporation
  • an ether carboxylate formed by an unneutralized ether carboxylic acid and a neutralizing agent may be contained.
  • the neutralization rate of the ether carboxylic acid is preferably 50 to 100%, more preferably 70 to 100%, and more preferably 90 to 100% from the viewpoint of improving the amount of foam and foamability. Is more preferable and 100% is more preferable.
  • the neutralizer is preferably one or two selected from potassium hydroxide and sodium hydroxide.
  • Acyl amino acid salts that can be used as component (A1) include N-acyl amino acids or salts thereof.
  • the acyl group of N-acylamino acid or a salt thereof is a saturated or unsaturated linear or branched chain having 4 to 30 carbon atoms from the viewpoint of exhibiting good foaming properties and further enhancing the effect of removing horn plugs.
  • fatty acids examples include caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid and the like.
  • these fatty acids from the same viewpoint as described above, one or more selected from lauric acid, myristic acid, palmitic acid, and oleic acid are preferable, and lauric acid is more preferable.
  • the acyl group of the N-acylamino acid may be derived from a mixed fatty acid of the above fatty acids, for example, obtained from coconut oil, palm kernel oil, or the like as a raw material. Especially, what was obtained from coconut oil fatty acid and palm kernel fatty acid as a raw material is preferable, and what was obtained from coconut oil fatty acid as a raw material is more preferable.
  • the amino acid part of N-acylamino acid or a salt thereof is a neutral amino acid selected from glycine and alanine, glutamic acid, and aspartic acid from the viewpoint of exhibiting good foaming properties and further enhancing the effect of removing horn plugs
  • An acidic amino acid selected from is preferable, an acidic amino acid is more preferable, and glutamic acid is more preferable.
  • these amino acid moieties may be any of D-form, L-form, or a mixture of D-form and L-form, and is preferably L-form.
  • N-acylamino acids or salts thereof may be used alone or in combination of two or more.
  • N-lauroyl glutamic acid, N-myristoyl glutamic acid, N-cocoyl glutamic acid, N-palm fatty acid glutamic acid, N-lauroyl aspartic acid, N-cocoyl glycine from the viewpoint of improving good foaming properties and smoothness of the skin.
  • N-cocoylalanine and one or more thereof selected from these salts, N-lauroyl glutamic acid, N-myristoyl glutamic acid, N-cocoyl glutamic acid, N-palm fatty acid glutamic acid, N-lauroyl aspartic acid, N More preferably one or more selected from cocoyl glycine and salts thereof, from N-lauroyl glutamic acid, N-myristoyl glutamic acid, N-cocoyl glutamic acid, N-lauroyl aspartic acid, and salts thereof It is more preferable to include one or more selected from N-cocoyl glutamic acid, N-lauroyl aspartic acid, and salts thereof, and more preferable to include N-cocoyl glutamic acid or a salt thereof. Even more preferred.
  • the N-acylamino acid or salt thereof is one or more salts selected from alkali metal salts, triethanolamine salts, and arginine salts from the viewpoint of reducing irritation to the skin and availability. It is more preferable that it is one or more salts selected from sodium salts, potassium salts, and triethanolamine salts, and it is more preferable that they are one or more salts selected from sodium salts and potassium salts. More preferably, it is a sodium salt.
  • N-acylamino acid when N-acylamino acid is used, it is preferable to use one that is neutralized with a base.
  • the neutralization rate of the N-acylamino acid is preferably 80 to 100%, more preferably 90 to 100%, and even more preferably 100% from the viewpoint of improving the amount of foam and foamability.
  • the neutralizing agent is preferably one or two selected from potassium hydroxide and sodium hydroxide.
  • the content of the component (A1) is preferably 0.01% by mass or more, and more preferably 0.05% by mass in the composition to be used, from the viewpoint of exhibiting good foaming properties and removal effect of square plugs. % Or more, more preferably 0.10% by mass or more, and further preferably 0.3% by mass or more.
  • the content of the component (A1) is preferably 5% by mass or less in the composition to be used from the viewpoint of preventing an increase in the burden on the skin and exhibiting an excellent effect of removing keratin plugs. Yes, more preferably 3% by mass or less, still more preferably 2.0% by mass or less, further preferably 1.5% by mass or less, and further preferably 1.0% by mass or less.
  • the content of the component (A1) in the composition to be used is preferably 0.01 to 5% by mass, more preferably 0.05 to 3% by mass, and still more preferably 0.05 to 2%. 0.0 mass%, more preferably 0.10 to 1.5 mass%, and still more preferably 0.3 to 1.0 mass%.
  • the content of component (A1) means, for example, when using the above fatty acid or salt thereof as component (A1), the equivalent amount of fatty acid, ether carboxylic acid or salt thereof, N-acylamino acid or When a salt is used, it means an acid equivalent amount.
  • the mass ratio ((X) / (A1)) between the content of the component (X) and the content of the component (A1) is from the viewpoint of exhibiting an excellent effect of removing a square plug. , Preferably it is 0.1 or more, More preferably, it is 0.5 or more, More preferably, it is 1.0 or more. Further, the mass ratio ((X) / (A1)) of the content of component (X) to the content of component (A1) exhibits an excellent removal effect of square plugs and maintains a good foaming property. From this viewpoint, it is preferably 100 or less, more preferably 80 or less, and still more preferably 70 or less.
  • the mass ratio ((X) / (A1)) of the content of component (X) to the content of component (A1) is preferably 0.1 to 100, more preferably 0.5 to 80. More preferably, it is 1.0 to 70.
  • component (X) is either component (X1) or (X2)
  • the mass ratio ((X) / (A1)) between the content of component (X) and the content of component (A1) is From the viewpoint of exhibiting an excellent removal effect of square plugs and maintaining good foamability, it is more preferably 2 or more, more preferably 5 or more, further preferably 8 or more, Preferably it is 60 or less, More preferably, it is 50 or less, More preferably, it is 40 or less, More preferably, it is 30 or less, More preferably, it is 20 or less.
  • the mass ratio ((X) / (A1)) between the content of component (X) and the content of component (A1) is more preferably 2 to 60, still more preferably 2 to 50, More preferably, it is 5 to 40, more preferably 8 to 30, and still more preferably 8 to 20.
  • the mass ratio ((X) / (A1)) between the content of the component (X) and the content of the component (A1) is an excellent square plug. From the viewpoint of exerting the removal effect and maintaining good foamability, it is more preferably 2 or more, more preferably 5 or more, further preferably 8 or more, more preferably 15 or more, Preferably it is 30 or more, More preferably, it is 40 or more.
  • the mass ratio ((X) / (A1)) between the content of component (X) and the content of component (A1) is more preferably 2 to 68, more preferably 5 to 65, More preferably, it is 8 to 62, more preferably 15 to 60, still more preferably 30 to 60, and still more preferably 40 to 60.
  • the “sulfonic acid group or sulfuric acid ester group” of the anionic surfactant having a sulfonic acid group or sulfuric acid ester group of the component (A2) is meant to include a sulfonic acid residue or a sulfuric acid ester residue.
  • examples of the anionic surfactant having a sulfonic acid group or a sulfate ester group of the component (A2) include alkylbenzene sulfonic acid or a salt thereof, alkane sulfonic acid or a salt thereof, alkenyl sulfonic acid or a salt thereof, alkyl sulfonic acid or a salt thereof.
  • the salt constituting the component (A2) is an inorganic salt selected from sodium salt, potassium salt, lithium salt, magnesium salt, ammonium salt, and organic amine selected from monoethanolamine salt, diethanolamine salt, and triethanolamine salt. Salts are preferred.
  • alkylbenzenesulfonic acid or a salt thereof, acylisethionic acid or a salt thereof, an alkylsulfuric acid ester or a salt thereof, an alkylethersulfuric acid from the viewpoint of maintaining a good foaming property while exhibiting an excellent removal effect of a square plug
  • alkyl sulfate ester salt examples include alkyl sulfate ester salts represented by the following general formula (2).
  • R 2 OSO 3 M 2 (2) In the formula (2), R 2 represents an aliphatic hydrocarbon group having 8 to 22 carbon atoms, and M 2 is selected from alkali metals, alkaline earth metals, ammonium, alkylammonium, alkanolammonium, and glucammonium. Indicates a cation.
  • R 2 is preferably an aliphatic hydrocarbon group having 8 to 18 carbon atoms from the viewpoint of maintaining excellent foaming properties while exhibiting excellent removal effects of square plugs.
  • An aliphatic hydrocarbon group having 8 to 16 carbon atoms is more preferable, and an aliphatic hydrocarbon group having 10 to 16 carbon atoms is more preferable.
  • an alkyl group or alkenyl group having 8 to 16 carbon atoms is preferable, an alkyl group or alkenyl group having 10 to 16 carbon atoms is more preferable, and an alkyl group or alkenyl group having 10 to 14 carbon atoms is still more preferable.
  • M 2 is preferably an alkali metal or ammonium, more preferably an alkali metal, and even more preferably a sodium salt, from the same viewpoint as described above.
  • alkyl sulfate salt examples include sodium lauryl sulfate, trilauramine lauryl sulfate, ammonium lauryl sulfate, sodium myristyl sulfate, sodium cetyl sulfate, sodium stearyl sulfate, sodium oleyl sulfate, triethanolamine oleyl sulfate and the like. It is done. Among these, it is preferable to include at least one selected from sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate. One of these compounds may be used alone, or two or more may be used in combination.
  • this alkyl sulfate ester salt for example, Emar 0S (manufactured by Kao Corporation, sodium lauryl sulfate), Emar 10PT (manufactured by Kao Corporation, sodium lauryl sulfate), Emar TD (manufactured by Kao Corporation, triethanol lauryl sulfate) Amine), Emar AD-25R (manufactured by Kao Corporation, ammonium lauryl sulfate) and the like.
  • Emar 0S manufactured by Kao Corporation, sodium lauryl sulfate
  • Emar 10PT manufactured by Kao Corporation, sodium lauryl sulfate
  • Emar TD manufactured by Kao Corporation, triethanol lauryl sulfate
  • Amine Emar AD-25R (manufactured by Kao Corporation, ammonium lauryl sulfate) and the like.
  • alkyl ether sulfate salts represented by the following general formula (3).
  • R 3 O (CH 2 CH 2 O) n SO 3 M 3 (3) (In the formula (3), R 3 represents an aliphatic hydrocarbon group having 8 to 22 carbon atoms, and M 3 is selected from alkali metals, alkaline earth metals, ammonium, alkylammonium, alkanolammonium, and glucammonium. Represents a cation, n represents the average number of moles added, and is 0.5 to 20.)
  • R 3 is preferably an aliphatic hydrocarbon group having 8 to 18 carbon atoms from the viewpoint of maintaining excellent foaming properties while exhibiting an excellent removal effect of square plugs.
  • An aliphatic hydrocarbon group having 8 to 16 carbon atoms is more preferable, and an aliphatic hydrocarbon group having 10 to 16 carbon atoms is more preferable.
  • an alkyl group or alkenyl group having 8 to 16 carbon atoms is preferable, an alkyl group or alkenyl group having 10 to 16 carbon atoms is more preferable, and an alkyl group or alkenyl group having 10 to 14 carbon atoms is still more preferable.
  • n is preferably 0.5 or more, preferably 12 or less, preferably 5 or less, more preferably 4 or less, and still more preferably 2 or less.
  • a specific range of n is preferably 0.5 to 12, more preferably 0.5 to 5, further preferably 0.5 to 4, and still more preferably 0.5 to 2.
  • M 3 is preferably an alkali metal or ammonium, more preferably an alkali metal, and even more preferably a sodium salt, from the same viewpoint as described above.
  • alkyl ether sulfate ester salt examples include polyoxyethylene (1) sodium lauryl ether sulfate, polyoxyethylene (1) ammonium lauryl ether sulfate, polyoxyethylene (1) sodium myristyl ether sulfate, polyoxyethylene ( 2) 1 type, or 2 or more types chosen from sodium lauryl ether sulfate and polyoxyethylene (2) sodium myristyl ether sulfate are mentioned.
  • the numerical value in the parenthesis of these compounds means the average added mole number of ethylene oxide.
  • this alkyl ether sulfate ester salt for example, Emar 125HP (manufactured by Kao Corporation, polyoxyethylene (1) sodium lauryl ether sulfate), Emar 125A (manufactured by Kao Corporation, polyoxyethylene (1) ammonium lauryl ether sulfate) ), Emar 227 (manufactured by Kao Corporation, polyoxyethylene (2) sodium lauryl ether sulfate) and the like.
  • the alkenyl sulfonic acid or salt thereof that can be used as the component (A2) is preferably a straight-chain hydrocarbon having 12 to 22 carbon atoms having a double bond, and more preferably 12 to 12 carbon atoms having a double bond.
  • 18 is an alkenyl sulfonic acid or a salt thereof, which is an 18 straight-chain hydrocarbon in which a sulfo group is bonded to any carbon atom except a terminal carbon atom.
  • alkenyl sulfonic acid having a sulfo group bonded to any carbon atom except the carbon atom or a salt thereof may be used singly or in combination of two or more, from the viewpoint of controlling foamability and foam quality, It is preferable to use a combination of two or more depending on the purpose of use.
  • an alkenyl sulfonic acid having 16 carbon atoms or a salt thereof, or an alkenyl sulfonic acid having 18 carbon atoms or a salt thereof is preferable. Further, it is preferable to use these alkenyl sulfonic acids having 16 carbon atoms or a salt thereof and alkenyl sulfonic acids having 18 carbon atoms or a salt thereof as a mixture.
  • the mass ratio of the alkenyl sulfonic acid of formula 18 or a salt thereof is preferably 1/9 to 9/1, more preferably 2/8 to 8/2, and further preferably 5/5 to 2/8.
  • Salts comprising alkenyl sulfonates include alkali metals such as sodium and potassium; alkaline earth metals such as calcium and magnesium; ammonium; salts composed of organic ammonium derived from monoethanolamine, diethanolamine, triethanolamine, etc. Is mentioned. Of these, alkali metal salts and ammonium salts are preferable from the viewpoint of availability in the market.
  • the alkylsulfonic acid or salt thereof that can be used as component (A2) is preferably a hydroxyalkylsulfonic acid having 12 to 22 carbon atoms or a salt thereof, more preferably a hydroxyalkylsulfonic acid having 12 to 22 carbon atoms or a salt thereof.
  • a salt thereof which is a hydroxyalkylsulfonic acid or a salt thereof having a sulfo group bonded to any carbon atom except the terminal carbon atom, and further a hydroxyalkylsulfonic acid having 12 to 18 carbon atoms or a salt thereof
  • a hydroxyalkylsulfonic acid or a salt thereof, which is a salt and has a sulfo group bonded to any carbon atom except the terminal carbon atom is preferred. More preferably, it is a straight-chain hydrocarbon having 12 to 18 carbon atoms, a hydroxyl group on any carbon atom except the terminal carbon atom, and a sulfo group on any carbon atom except the terminal carbon atom.
  • a hydroxyalkylsulfonic acid or a salt thereof bonded to each other is preferred.
  • hydroxyalkyl sulfonic acids having 12 to 22 carbon atoms or salts thereof may be used alone or in combination of two or more, from the viewpoint of controlling foamability and foam quality. It is preferable to use a combination of two or more depending on the purpose of use. Further, from the viewpoint of foamability and foam quality, a hydroxyalkylsulfonic acid having 16 carbon atoms or a salt thereof, or a hydroxyalkylsulfonic acid having 18 carbon atoms or a salt thereof is preferable.
  • a hydroxyalkyl sulfonic acid having 16 carbon atoms or a salt thereof and a hydroxyalkyl sulfonic acid having 18 carbon atoms or a salt thereof is preferable.
  • the mass ratio of the hydroxyalkylsulfonic acid having 18 carbon atoms or a salt thereof (hydroxyalkylsulfonic acid having 16 carbon atoms or salt thereof / hydroxyalkylsulfonic acid having 18 carbon atoms or salt thereof) from 9/1 to 1/9 It is preferably 8/2 to 2/8, more preferably 5/5 to 2/8.
  • Salts comprising alkyl sulfonates include alkali metals such as sodium and potassium; alkaline earth metals such as calcium and magnesium; ammonium; salts composed of organic ammonium derived from monoethanolamine, diethanolamine, triethanolamine, etc. Is mentioned. Of these, alkali metal salts and ammonium salts are preferable from the viewpoint of availability in the market.
  • any one of alkenyl sulfonic acid or a salt thereof, or alkyl sulfonic acid or a salt thereof may be used. Also good. When these mixtures are used, the mass ratio of alkenyl sulfonic acid or salt thereof to alkyl sulfonic acid or salt thereof (alkenyl sulfonic acid or salt thereof / alkyl sulfonic acid or salt thereof) is 5/95 to 50/50. Is preferable, and 10/90 to 30/70 is more preferable. In addition, alkenyl sulfonic acid or a salt thereof, alkyl sulfonic acid or a salt thereof can be produced, for example, by the method described in JP-A-2015-28123.
  • the content of the component (A2) is preferably 0.01% by mass or more in the composition used in the present invention, and more preferably from the viewpoint of exhibiting a good effect of removing horn plugs and foaming properties.
  • the content of the component (A2) in the composition to be used is more preferably 0.01 to 20% by mass, more preferably 0.03 to 18% by mass, and still more preferably 0.05 to 20% by mass. It is 18% by mass, and more preferably 0.10-15% by mass.
  • the content of the component (A2) is determined in the present invention from the viewpoint of exhibiting a good plug removal effect and foamability.
  • the composition to be used it is more preferably 0.2 or more, further preferably 0.3% by mass or more, and further preferably 0.5% by mass or more. Further, it is more preferably 12% by mass or less, further preferably 10% by mass or less, further preferably 8% by mass, further preferably 5% by mass or less, and further preferably 4% by mass or less. More preferably, it is 3% by mass or less.
  • the content of the component (A2) in the composition to be used is more preferably 0.2 to 12% by mass, further preferably 0.2 to 10% by mass, and 0.2 to 8% by mass. More preferably, it is 0.3 to 5% by mass, more preferably 0.3 to 4% by mass, and further preferably 0.5 to 3% by mass.
  • the content of the component (A2) is preferably in the composition used in the present invention from the viewpoint of exhibiting a good horn plug removal effect and foaming property.
  • 0.2% or more more preferably 0.3% by mass or more, further preferably 0.5% by mass or more, more preferably 1.0% by mass or more, and further preferably 1.5% by mass or more. More preferably, it is 2.0 mass% or more.
  • it is preferably 14% by mass or less, more preferably 13% by mass or less, further preferably 12% by mass or less, further preferably 11% by mass or less, and further preferably 10% by mass or less. .
  • the content of the component (A2) in the composition to be used is preferably 0.2 to 14% by mass, more preferably 0.3 to 14% by mass, and further preferably 0.5 to 13%.
  • % By mass more preferably 1.0 to 12% by mass, further preferably 1.5 to 11% by mass, and further preferably 2.0 to 10% by mass.
  • the mass ratio ((X) / (A2)) between the content of component (X) and the content of component (A2) is preferably from the viewpoint of maintaining good foamability.
  • 0.005 or more more preferably 0.01 or more, further preferably 0.10 or more, more preferably 0.20 or more, still more preferably 0.25 or more, and further preferably It is 0.3 or more, more preferably 0.5 or more.
  • it is preferably 100 or less, more preferably 60 or less, and even more preferably 50 or less.
  • the mass ratio ((X) / (A2)) between the content of component (X) and the content of component (A2) is preferably 0.005 to 100, more preferably 0.01 to 60. More preferably, it is 0.10 to 50, more preferably 0.20 to 40, further preferably 0.20 to 30, more preferably 0.20 to 20, and further preferably It is 0.25 to 15, more preferably 0.3 to 14, and further preferably 0.50 to 12.5.
  • anionic surface activity other than the components (A1) and (A2) can also be used.
  • anionic surfactant other than the components (A1) and (A2) include phosphate ester type surfactants, specifically alkyl phosphate ester salts, polyoxyethylene alkyl ether phosphates, alkyl aryl ethers. Examples thereof include phosphate, fatty acid amide ether phosphoric acid and the like.
  • the content of the anionic surfactant other than the components (A1) and (A2) can be influenced by the dosage form of the composition to be used.
  • composition is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, further preferably 0.10% by mass or more, preferably 10%. It is not more than mass%, more preferably not more than 5 mass%, still more preferably not more than 1.0 mass%, still more preferably not more than 0.5 mass%.
  • the total content of the component (A) is preferably 0.01% by mass or more, more preferably 0.02 in the composition to be used, from the viewpoint of exhibiting a good removal effect of the plug and foaming property. % By mass or more, more preferably 0.05% by mass or more, further preferably 0.1% by mass or more, further preferably 0.3% by mass or more, and further preferably 0.5% by mass. That's it. Further, the content of the component (A) is preferably 30% by mass or less, more preferably 20% by mass or less, in the composition to be used, from the viewpoint of preventing an increase in the burden on the skin.
  • the content of the component (A) is preferably 0.01 to 30% by mass, more preferably 0.02 to 20% by mass, and further preferably 0.05 to 15% in the composition to be used.
  • % By mass, more preferably 0.1 to 12% by mass, 0.1 to 10% by mass, further preferably 0.3 to 8% by mass, and further preferably 0.5 to 4% by mass. %.
  • the composition of the present invention preferably further contains a nonionic surfactant (B) from the viewpoint of exhibiting good sebum detergency and makeup removal and further enhancing the effect of removing the plug.
  • a component (B) it is preferable to contain nonionic surfactant (B1) more than HLB11 from a viewpoint of improving sebum detergency and the removal effect of a square plug.
  • the HLB of the component (B1) is 11 or more, preferably 12 or more, more preferably 13 or more, preferably 20 or less, more preferably 19 or less, and further preferably 18 or less. It is.
  • the HLB of the component (B1) is 11 or more, preferably 11 to 20, more preferably 12 to 19, and still more preferably 13 to 18.
  • HLB hydrophilic-lipophilic balance
  • nonionic surfactant of component (B1) examples include polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene polyoxypropylene glycol, polyoxyethylene sorbitan fatty acid ester, polyoxy Ethylene sorbite fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkyl ether fatty acid ester, sucrose fatty acid ester, alkyl polyglucoside, (Poly) alkyl glyceryl ether etc. are mentioned.
  • polyglycerin fatty acid ester polyethylene glycol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil fatty acid ester, polyoxy It is preferable to include one or more selected from ethylene alkyl ether and alkyl polyglucoside, and one selected from polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene sorbitan fatty acid ester and alkyl polyglucoside Or it is more preferable that 2 or more types are included.
  • polyoxyethylene sorbitan fatty acid ester As a commercially available product of polyoxyethylene sorbitan fatty acid ester, polyoxyethylene (6) sorbitan laurate (Leodol TW-L106 (HLB13.3), manufactured by Kao Corporation) and the like are preferable.
  • a commercially available polyethylene glycol fatty acid ester is preferably polyethylene glycol monolaurate (12EO) (Emanon 112 (HLB13.7), manufactured by Kao Corporation).
  • polyoxyethylene alkyl ether examples include polyoxyethylene (21) lauryl ether (Emulgen 121-G (HLB16.6), manufactured by Kao Corporation), polyoxyethylene (20) 2-hexyldecyl ether (Emulgen 1620G ( HLB14), manufactured by Kao Corporation, polyoxyethylene (16) lauryl ether (Emulgen 116 (HLB15.8), manufactured by Kao Corporation), polyoxyethylene (9) lauryl ether (Emulgen 109P (HLB13.6), manufactured by Kao Corporation) ), Polyoxyethylene (20) octyldodecyl ether (Emulgen 2020G (HLB13.3), manufactured by Kao Corporation), polyoxyethylene (25) octyldodecyl ether (Emulgen 2025G (HLB14.1), manufactured by Kao Corporation) and the like are preferable.
  • decyl glucoside (Mydol 10 (HLB15.7), manufactured by Kao Corporation), lauryl glucoside (Mydol 12 (HLB17), manufactured by Kao Corporation) and the like are preferable.
  • the nonionic surfactant (B2) is less than HLB11 from a viewpoint of exhibiting better makeup removal.
  • the HLB of the component (B2) is less than 11, preferably 10 or less, more preferably 9 or less, preferably 4 or more, more preferably HLB 5 or more, and further preferably HLB 6 or more.
  • the HLB of the component (B2) is less than 11, preferably 4 to 10, more preferably 5 to 10, and further preferably 6 to 9.
  • nonionic surfactant of component (B2) examples include ethylene glycol fatty acid esters such as ethylene glycol monostearic acid ester, polyethylene glycol fatty acid esters such as polyethylene glycol (2) monostearic acid ester, and polyethylene glycol (5).
  • Polyethylene glycol surfactants such as polyethylene glycol alkyl ethers such as decyl pentadecyl ether, polyethylene glycol (5) polyethylene glycol hydrogenated castor oil such as hydrogenated castor oil monoisolaurate; propylene glycol fatty acid ester, polypropylene glycol fatty acid ester, propylene Ethylene oxide of glycol alkyl ether, polypropylene glycol alkyl ether, propylene glycol alkyl ether Propylene glycol surfactants such as conductors; Glycerin fatty acid esters such as glycerin monoisostearic acid; Glycerin alkyl ethers such as glycerin monoisostearyl ether; Sorbitan fatty acid esters such as sorbitan monostearic acid ester; Poly such as polyglyceryl monoisostearate Examples include glycerin fatty acid esters. Especially, it is preferable to contain the 1 type (s) or
  • polyoxyethylene alkyl ether examples include polyoxyethylene (2) lauryl ether (Emulgen 102 (HLB 6.4), manufactured by Kao Corporation), polyoxyethylene (3) lauryl ether (Emulgen 103 (HLB 8.3), Kao), polyoxyethylene (5) lauryl ether (Emulgen 105 (HLB10), manufactured by Kao) and the like are preferable.
  • polyglycerin fatty acid ester polyglyceryl isostearate (Cosmol 41V (HLB8), manufactured by Nisshin Oillio Group) is preferable.
  • the mass ratio ((B1) of the content of the nonionic surfactant of HLB11 or higher of the component (B1) and the content of nonionic surfactant of HLB11 lower than the component (B2). ) / (B2)) is preferably 0.1 or more, more preferably 0.6 or more, still more preferably 0.8 or more, and more preferably 1.5 or more, from the viewpoint of exhibiting good sebum detergency and makeup removal. More preferably, 2.5 or more is more preferable, 5 or more is more preferable, 25 or less is preferable, 20 or less is more preferable, 16 or less is further preferable, 14 or less is further preferable, and 12 or less is further preferable.
  • mass ratio ((B1) / (B2) of content of nonionic surfactant more than HLB11 of component (B1) and content of nonionic surfactant less than HLB11 of component (B2) ) Is preferably from 0.1 to 25, more preferably from 0.6 to 20, still more preferably from 0.8 to 16, still more preferably from 1.5 to 14, still more preferably from 2.5 to 12, and from 5 to 12 Is more preferable.
  • the content of the component (B) is preferably 0.1% by mass or more in the composition to be used, from the viewpoint of exhibiting good sebum detergency and makeup removal and further enhancing the effect of removing keratin plugs. 4 mass% or more is more preferable, 0.5 mass% or more is more preferable, 30 mass% or less is preferable, 25 mass% or less is more preferable, 20 mass% or less is further preferable, 18 or less is more preferable, 15 mass% % Or less is more preferable and 10 mass% or less is more preferable. Further, the content of the component (B) is preferably 0.1 to 30% by mass, more preferably 0.4 to 25% by mass, further preferably 0.5 to 20% by mass in the composition to be used. It is more preferably 5 to 18% by mass, further preferably 0.5 to 15% by mass, and further preferably 0.5 to 10% by mass.
  • the mass ratio ((X) / (B)) of the content of the component (X) and the content of the component (B) exhibits an excellent effect of removing horn plugs and cleans sebum From the viewpoint of improving the properties and makeup removal, it is preferably 0.01 or more, more preferably 0.02 or more, more preferably 0.03 or more, more preferably 0.1 or more, and further preferably It is 0.3 or more, more preferably 0.5 or more.
  • mass ratio ((X) / (B)) of content of component (X) and content of component (B) exhibits the outstanding removal effect of a square plug.
  • the mass ratio ((X) / (B)) between the content of component (X) and the content of component (B) is preferably 0.01 to 50, More preferably, it is 0.02 to 30, more preferably 0.03 to 25, still more preferably 0.1 to 25, still more preferably 0.3 to 20, and still more preferably 0.5. To 20, more preferably 0.5 to 15.
  • composition of the present invention can further contain an amphoteric surfactant (C) from the viewpoint of improving foamability.
  • amphoteric surfactants include amide amino acid type surfactants, carbobetaine type surfactants, amide betaine type surfactants, amide sulfobetaine type surfactants, sulfobetaine type surfactants and the like.
  • the content of these amphoteric surfactants can be influenced by the dosage form of the composition of the present invention, but from the viewpoint of enhancing the effect of removing horn plugs and obtaining excellent foaming properties, , Preferably 0.1% by mass or more, more preferably 0.5% by mass or more, further preferably 1% by mass or more, and preferably 15% by mass or less, more preferably 10% by mass. % Or less, and more preferably 5% by mass or less.
  • the content of component (C) is preferably 0.1 to 15% by mass, more preferably 0.5 to 10% by mass, and further preferably 1 to 5% by mass in the composition to be used. It is.
  • the composition of the present invention preferably further contains a polyol (D) from the viewpoint of imparting a moist feeling to the skin while exhibiting an excellent effect of removing plugs.
  • a polyol (D) examples include dihydric alcohols such as ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, isoprene glycol, hexylene glycol, and 1,3-butylene glycol; Trihydric or higher alcohols such as glycerin, triglycerin, tetraglycerin, hexaglycerin, decaglycerin, trimethylpropanol; erythritol, pentaerythritol, dipentaerythritol, glucose, mannose, galactose, sucrose, fructose, maltose, trehalose, maltitol , Sugars such as xylitol, ino
  • such component (D) is composed of ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, isoprene glycol.
  • dipropylene glycol, 1,3-butylene glycol, glycerol preferably contains one or two kinds selected from sorbitol and mannitol.
  • the content of the component (D) is preferably 0.5% by mass or more, more preferably 1%, in the composition to be used, from the viewpoint of exhibiting an excellent effect of removing plugs and imparting moist feeling to the skin. 0.0% by mass or more, more preferably 3% by mass or more, further preferably 5% by mass or more, further preferably 8% by mass or more, 10% by mass or more, and preferably 40% by mass. It is at most mass%, more preferably at most 35 mass%, even more preferably at most 30 mass%, further preferably at most 25 mass%, further preferably at most 20 mass%.
  • the content of component (D) in the composition to be used is preferably 0.5 to 40% by mass, more preferably 1.0 to 35% by mass, and further preferably 3 to 30% by mass. More preferably, it is 5 to 25% by mass, more preferably 8 to 20% by mass, and further preferably 10 to 20% by mass.
  • the composition of the present invention preferably further contains a water-soluble polymer (E) from the viewpoint of suppressing dripping at the time of application and improving aging stability while exhibiting an excellent effect of removing horn plugs.
  • the water-soluble polymer of the component (E) may be any as long as it is used for ordinary compositions. Specifically, a carboxyvinyl polymer, a copolymer of acrylic acid / alkyl (meth) acrylate, cellulose with a hydroxyethyl group or hydroxypropyl group added, suppresses dripping at the time of coating, and improves stability over time. From a viewpoint of improving, it is mentioned as a suitable water-soluble polymer.
  • carboxyvinyl polymer examples include Carbopol 980, Carbopol 981 (manufactured by Lubrizol Advanced Materials), and acrylic acid / (meth) acrylic acid alkyl copolymers such as Pemulene TR-1 and Pemulene TR-. 2, Carbopol ETD2020, Carbopol 1382, Carbopol 1342, Carbopole Ultrez 10, Carbopol Ultrez 20, Carbopol Ultrez 21 (manufactured by Lubrizol Advanced Materials, etc.), manufactured by AQUPEC HV-501ER Commercial products can be used.
  • a cellulose to which a hydroxyethyl group or a hydroxypropyl group is added is one in which a part of hydrogen atoms in the hydroxyl group of cellulose is substituted with a hydroxyethyl group or a hydroxypropyl group, and has a substituent other than these. May be. Specific examples include hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethyl methyl cellulose, hydroxypropyl methyl cellulose, and the like.
  • celluloses are made by reacting cellulose with caustic soda to make alkaline cellulose, then methyl chloride, monochloroacetic acid, ethylene oxide, propylene oxide, etc., and the hydrogen atom in the hydroxyl group of cellulose is hydroxyethyl group, hydroxypropyl group, methyl group, It is obtained by substitution with a carboxymethyl group or the like.
  • These celluloses have an average substitution degree of more than 0, more preferably 0.5 or more, more preferably 3 or less, and more preferably 2 or less, from the viewpoint of suppressing sagging during coating and improving the stability over time.
  • the weight average molecular weight is preferably 200,000 or more, more preferably 500,000 or more, more preferably 650,000 or more, preferably 3,000,000 or less, and 2,000,000 or less. Is more preferable, and 1,600,000 or less is still more preferable.
  • the average degree of substitution is determined by NMR, and the weight average molecular weight is determined by using a gel permeation chromatography (GPC) -multi-angle laser light scattering detector (MALLS) system with polyethylene oxide as the standard substance.
  • GPC gel permeation chromatography
  • MALLS multi-angle laser light scattering detector
  • the cellulose to which a hydroxyethyl group or a hydroxypropyl group is added is preferably hydroxyethyl cellulose or hydroxypropyl methylcellulose, preferably having an average degree of substitution of 0.5 to 2 and a weight average molecular weight of 650,000 to 1,600,000. .
  • Examples of the cellulose to which a hydroxyethyl group or a hydroxypropyl group is added include, for example, CELLOSIZE QP52000H (manufactured by Dow Chemical Co., Ltd.), HEC Daicel SE400, SE500, SE600, SE850, SE900 (manufactured by Daicel Finechem), etc.
  • the content of the component (E) is preferably 0.01% by mass in the composition to be used from the viewpoint of suppressing dripping at the time of application and improving aging stability while exhibiting an excellent effect of removing horn plugs. Or more, more preferably 0.05% by mass or more, further preferably 0.10% by mass or more, further preferably 0.15% by mass or more, and preferably 3% by mass or less. More preferably, it is 2 mass% or less, More preferably, it is 1.0 mass% or less, More preferably, it is 0.8 mass% or less.
  • the content of the component (E) in the composition to be used is preferably 0.01 to 3% by mass, more preferably 0.05 to 2% by mass, and still more preferably 0.1 to 1%. 0.0 mass%, more preferably 0.15-0.8 mass%.
  • the composition of the present invention is one or more selected from neutral amino acids, betaine-type compounds and ethylenediamine tetraacetate from the viewpoint of imparting a moist feeling to the skin while exhibiting an excellent effect of removing horn plugs. It is preferable to contain (F).
  • the neutral amino acid of component (F) include glycine, sarcosine, L-serine, ⁇ -alanine, aminobutyric acid, and the like
  • betaine-type compounds other than component (C) include trimethylglycine, Examples include trimethylserine, hydroxyethyldimethylglycine, monoethanol-C5-carboxybetaine and the like.
  • such component (F) is one or two selected from trimethylglycine, trimethylserine, hydroxyethyldimethylglycine and monoethanol-C5-carboxybetaine. It is preferable to include the above, more preferably one or more selected from trimethyl glycine, trimethyl serine and hydroxyethyl dimethyl glycine, more preferably trimethyl glycine.
  • the content of the component (F) in the composition is preferably 0.1% by mass or more in the composition to be used, from the viewpoint of imparting a moist feeling to the skin while exhibiting an excellent effect of removing plugs.
  • 0.5 mass% or more is more preferable, 1.0 mass% or more is more preferable, 20 mass% or less is preferable, 15 mass% or less is more preferable, and 10 mass% or less is more preferable.
  • the content of the component (F) is preferably 0.1 to 20% by mass, more preferably 0.5 to 15% by mass, and further preferably 1.0 to 10% in the composition to be used. % By mass.
  • the composition of the present invention contains water (G) from the viewpoint of satisfactorily dissolving or dispersing the above components.
  • the water content is preferably 10% by mass or more, more preferably 20% by mass or more, still more preferably 30% by mass or more, and preferably 99.9% by mass in the composition of the present invention. % Or less, more preferably 99.5% by mass or less, and still more preferably 99% by mass or less.
  • composition of the present invention is within the range not impairing the effects of the present invention, in addition to the above-mentioned components, for example, oil agents such as hydrocarbon oil, ester oil, ether oil, vegetable oil, sodium lactate, Moisturizers other than component (D) and component (E) such as urea and sodium pyrrolidone carboxylate; ultraviolet absorbers; antioxidants; bactericides; extracts; fragrances;
  • Each of these agents is not limited to the use as each agent, but can be diverted to other uses according to the purpose, for example, using an antiperspirant as a fragrance, or combined with other uses, for example, antiperspirant. It can be used as an agent and an effect as a fragrance.
  • the pH at 25 ° C. of the composition used in the present invention is 8.5 or more from the viewpoint of sufficiently exhibiting the effect of removing horn plugs when such a composition is contained alone as any one of the components (X). Preferably, it is 12.5 or less.
  • the pH at 25 ° C. of the composition used in the present invention is such that the composition contains 2-amino-2-hydroxymethyl-1,3-propanediol (X1) alone as component (X).
  • it is preferably 8.6 or more, more preferably 8.8 or more, further preferably 9.0 or more, Preferably it is 9.2 or more, More preferably, it is 9.3 or more, More preferably, it is 9.5 or more, More preferably, it is 9.8 or more, More preferably, it is 10.0 or more.
  • the pH at 25 ° C. of the composition used in the present invention is preferably 8.6 to 12.5, more preferably 8.8 to 12.2, and still more preferably 9.0 to 12.0. More preferably, it is 9.2 to 11.8, more preferably 9.3 to 11.8, still more preferably 9.5 to 11.5, and still more preferably 9.8 to 11 .2 and more preferably 10.0 to 11.0.
  • the pH at 25 ° C. of the composition used in the present invention is the above when the composition contains 2-amino-2-methyl-1-propanol (X2) alone as component (X). From the viewpoint of sufficiently exhibiting the effect of removing the plugs due to component (X), it is preferably 9.0 or more, more preferably 9.2 or more, still more preferably 9.3 or more, and even more preferably 9 It is 0.5 or more, More preferably, it is 9.8 or more, More preferably, it is 10.0 or more, More preferably, it is 10.2 or more, More preferably, it is 10.5 or more.
  • the pH at 25 ° C. of the composition used in the present invention is preferably 9.0 to 12.5, more preferably 9.2 to 12.2, and still more preferably 9.3 to 12.2. More preferably, it is 9.5 to 12.0, more preferably 9.8 to 11.8, still more preferably 10.0 to 11.5, and still more preferably 10.2 to 11. 0.5, more preferably 10.2 to 11.2, still more preferably 10.5 to 11.2, and still more preferably 10.5 to 11.0.
  • the pH at 25 ° C. of the composition used in the present invention is such that when the composition contains 2-amino-2-methyl-1,3-propanediol (X3) alone as component (X),
  • the pH at 25 ° C. of such a composition is preferably 8.5 or more, more preferably 8.8 or more, and still more preferably, from the viewpoint of sufficiently exerting the effect of removing the plug due to the component (X).
  • the pH at 25 ° C. of the composition used in the present invention is preferably 8.5 to 12.5, more preferably 8.8 to 12.2, and still more preferably 9.0 to 12.0.
  • it is 9.2 to 11.8, more preferably 9.3 to 11.8, still more preferably 9.5 to 11.5, and still more preferably 9.8 to 11 0.5, more preferably 10.0 to 11.5, more preferably 10.2 to 11.2, still more preferably 10.5 to 11.2, and even more preferably 10.5. ⁇ 11.0.
  • the pH at 25 ° C. is preferably 8.3 or more, more preferably 8.5 or more, and even more preferably 8.8 or more, from the viewpoint of sufficiently exerting the effect of removing horn plugs by the component (X). More preferably, it is 9.0 or more, More preferably, it is 9.2 or more, More preferably, it is 9.3 or more, More preferably, it is 9.5 or more, More preferably, it is 9.8 or more More preferably, it is 10.0 or more.
  • the composition used in the present invention is preferably 12.5 or less, more preferably 12.2 or less, and still more preferably 12 from the viewpoint of suppressing an excessive burden on the skin. 0.0 or less, more preferably 11.8 or less, further preferably 11.5 or less, further preferably 11.2 or less, and further preferably 11.0 or less.
  • the pH at 25 ° C. of the composition used in the present invention is preferably 8.3 to 12.5, more preferably 8.5 to 12.2, and further preferably 8.8 to 12.0. More preferably, it is 9.0 to 12.0, more preferably 9.2 to 11.8, still more preferably 9.3 to 11.8, and still more preferably 9.5 to 11 0.5, more preferably 9.8 to 11.2, and even more preferably 10.0 to 11.0.
  • the composition used by this invention may contain pH adjusters, such as sodium hydroxide, sodium carbonate, sodium citrate, hydrochloric acid, suitably.
  • the pH at 25 degreeC of the composition used by this invention is the said component.
  • it is preferably 8.3 or more, more preferably 8.5 or more, further preferably 8.8 or more, and further preferably 9. It is 0 or more, More preferably, it is 9.2 or more, More preferably, it is 9.3 or more, More preferably, it is 9.5 or more, More preferably, it is 9.8 or more, More preferably, it is 10. 0 or more.
  • the composition used in the present invention is preferably 12.5 or less, more preferably 12.2 or less, and still more preferably 12 from the viewpoint of suppressing an excessive burden on the skin. 0.0 or less, more preferably 11.8 or less, further preferably 11.5 or less, further preferably 11.2 or less, and further preferably 11.0 or less.
  • the pH at 25 ° C. of the composition used in the present invention is preferably 8.3 to 12.5, more preferably 8.5 to 12.2, and further preferably 8.8 to 12.0. More preferably, it is 9.0 to 12.0, more preferably 9.2 to 11.8, still more preferably 9.3 to 11.8, and still more preferably 9.5 to 11 0.5, more preferably 9.8 to 11.2, and even more preferably 10.0 to 11.0.
  • the composition used by this invention may contain pH adjusters, such as sodium hydroxide, sodium carbonate, sodium citrate, hydrochloric acid, suitably.
  • the composition used in the present invention contains 2-amino-2-hydroxymethyl-1,3-propanediol (X1), 2-amino-2-methyl-1-propanol (X2), and 2-amino One or more (X) selected from -2-methyl-1,3-propanediol (X3) is contained.
  • a composition can be used without particular limitation as cosmetics, quasi drugs, pharmaceuticals and the like. Among them, from the viewpoint of fully enjoying the excellent removal effect of keratin plugs, it can be used as a keratin plug removal composition or keratin plug remover, and can be suitably used as a skin cosmetic for pore cleaning to suppress pore conspicuousness.
  • the application site of the composition of the present invention is preferably the skin of the body, more preferably the skin excluding the scalp such as the face, neck, limbs, or torso, and more preferably the pore region on these skins. More preferably, it is a pore part on the skin from the face of the face to the tip of the nose, the composition is applied to these desired parts, and the composition remaining on the application part after a lapse of time is washed away with water or a tissue, a nonwoven fabric, It can be used by wiping with a wiping material such as a woven fabric, preferably by rinsing with water.
  • the above composition can be suitably used as a skin cosmetic for improving skin lightness from the viewpoint of not only effectively removing horn plugs but also increasing skin lightness and reducing skin dullness,
  • it can be suitably used as a skin cosmetic for improving skin dullness. That is, by applying these cosmetics to the skin, the usefulness of the composition can be enhanced as a method for improving skin lightness or a method for improving skin dullness.
  • the said composition can be utilized suitably as an external preparation for acne suppression from a viewpoint which can remove a square plug effectively and can eliminate the cause of an acne. That is, by applying such an external preparation to the skin, the usefulness of the composition can be enhanced as a method for suppressing acne.
  • the above composition can be suitably used as a composition for promoting skin penetration from the viewpoint of effectively removing the horn plugs to promote the penetration of the drug from the pores and enhancing the effect of the drug. . That is, by applying the composition to the skin, the usefulness of the composition can be enhanced as a method for promoting skin penetration.
  • the composition can suppress protein aggregation, it can be suitably used as a protein aggregation inhibitor, and by applying the composition to the skin, Usability can be increased.
  • compositions used in the present invention are hair cosmetics such as shampoos, rinses and conditioners, facial cleansers, cleansing cosmetics, body cleansers, scalp cleansers, lotions, milky lotions, creams, cosmetics, sunscreen cosmetics, packs, It can be suitably used as skin cosmetics such as massage cosmetics. Among these, it is preferably applied as a skin cleanser such as a facial cleanser, a cleansing cosmetic, a body cleanser, a scalp cleanser.
  • the usage form of the composition used in the present invention can be appropriately selected according to the application site and the like.
  • the dosage form of the composition of the present invention is a liquid form, paste form, cream form, or the like
  • the composition may be applied directly to the application site.
  • the composition is applied to the application site in an amount of preferably 0.05 to 2 mL / cm 2 , more preferably 0.1 to 1 mL / cm 2 , and then usually 10 seconds to 10 minutes, preferably 15 Massage at the application site for 2 seconds to 5 minutes, more preferably 30 seconds to 4 minutes, more preferably 1 to 3 minutes, and then wash away the composition remaining on the application site with water, or a tissue, nonwoven fabric, woven fabric, etc. It is desirable to wipe off with a wiping material, preferably with water.
  • the dosage form of the composition used in the present invention when it is liquid, it can be impregnated into a sheet agent such as a nonwoven fabric or a woven fabric and used as a sheet-like cleaning agent.
  • the sheet-like cleaning agent impregnated with the composition is usually left for 1 minute to 30 minutes, preferably 5 minutes to 20 minutes, more preferably 10 minutes to 15 minutes, while being applied to the application site, The sheet-like cleaning agent is peeled off, and then the composition remaining at the application site is washed away with water, or wiped off with a wiping material such as tissue, nonwoven fabric, woven fabric, etc., preferably washed away with water.
  • a liquid composition may be filled into a foam discharge container and discharged from the container to the application site during use.
  • the usage may be the same as in the case of application.
  • Such a foamy dosage form is suitable for massaging at the application site.
  • composition used in the present invention may be filled in a spray container or a high-pressure washer and sprayed from a nozzle during use. At this time, washing is usually performed by spraying to the adaptation site for 10 seconds to 5 minutes, preferably 15 seconds to 3 minutes, more preferably 30 seconds to 2 minutes. Next, it is desirable that the composition remaining at the application site is washed away with water, or wiped off with a wiping material such as tissue, nonwoven fabric, woven fabric, etc., preferably with water.
  • a wiping material such as tissue, nonwoven fabric, woven fabric, etc.
  • step (I) in which water is preliminarily heated to 60 to 80 ° C., component (X) and other components as necessary are sequentially added to the water obtained in step (I). Then, it can be obtained by a production method comprising a step (II) of mixing and stirring, and a step (III) of cooling the mixture obtained in the step (II) to 20 to 35 ° C.
  • the step (II) is preferably a step that takes this into account. That is, in the step (II), before adding the component (X), the components other than the component (X) are first mixed in order, mixed and stirred to dissolve each component, and then the neutralizing agent is added. Then, after neutralizing the acidic component, component (X) is added, mixed and stirred to dissolve (step (II) ′), and the process may proceed to step (III).
  • the acidic component may be directly neutralized by component (X) without using a neutralizing agent as in step (II) ′. That is, in the step (II), before adding the component (X), the components other than the component (X) are first mixed sequentially, mixed and stirred to dissolve each component, and the component (X) is added. Then, after neutralizing the acidic component, the step (II) '' may be performed by mixing and stirring to dissolve, and the process may proceed to the above step (III).
  • the amount of component (X) added in step (II) '' is the component (X) necessary for neutralization of the acidic component to the content of component (X) in the free state in the resulting composition. The amount obtained by adding the amount of.
  • the present invention further discloses a method for removing horn plugs using the following composition, a composition for removing horn plugs, and the like.
  • a method for removing horn plugs using the following composition a composition for removing horn plugs, and the like.
  • X1 2-amino-2-hydroxymethyl-1,3-propanediol
  • X2 2-amino-2-methyl-1-propanol
  • X3 2-amino-2-methyl-1,3-
  • X3 propanediol
  • component (X) When component (X) is used as one component (X), it preferably contains 2-amino-2-hydroxymethyl-1,3-propanediol (X3), and two components (X) When used, one selected from 2-amino-2-hydroxymethyl-1,3-propanediol (X1) and 2-amino-2-methyl-1-propanol (X2), and 2-amino-2- A method for removing the horn plug of the above [1] containing methyl-1,3-propanediol (X3).
  • the total content of component (X) in the composition is preferably 0.08% by mass or more, more preferably 0.10% by mass or more, and further preferably 0.5% by mass or more.
  • the mass ratio (content of component (X) in the free state / content of component (X)) between the content of the component (X) present in free form and the content of component (X) is The method of removing any one of the above-mentioned [1] to [3], which is preferably 0.6 or more, more preferably 0.8 or more, and further preferably 0.9 or more.
  • the composition further contains a basic substance other than the component (X), and the total content of the component (Y) is preferably 0.01% by mass or more, more preferably in the composition. 0.05% by mass or more, more preferably 0.10% by mass or more, preferably 15% by mass or less, more preferably 12% by mass or less, and further preferably 10% by mass or less.
  • [1] to [4] A method of removing any one of the square plugs.
  • the component (Y) includes one or more selected from a chain or cyclic aliphatic amine, a basic amino acid, an inorganic salt composed of a strong base and a weak acid, and an aromatic amine, preferably 1 type or 2 or more types chosen from aliphatic amine and basic amino acid are included, More preferably, 1 type or 2 or more types chosen from arginine, monoethanolamine, triethanolamine, and morpholine are included, More preferably The method for removing the horn plug of the above-mentioned [5], comprising one or two selected from arginine and triethanolamino, and more preferably containing arginine.
  • the total content of component (X) and component (Y) is preferably 50% by mass or less, more preferably 32% by mass or less, and more preferably 25% by mass or less in the composition. More preferably 20% by mass or less, further preferably 15% by mass or less, further preferably 12% by mass or less, preferably 0.09% by mass or more, more preferably 0.15% or more. More preferably, it is 0.50% by mass or more, further preferably 1.0% by mass or more, more preferably 2% by mass or more, further preferably 3% by mass or more, and further preferably The method of removing the square plug of the above-mentioned [5] or [6], which is 5% by mass or more, more preferably more than 5% by mass.
  • the mass ratio ((X) / (Y)) between the content of component (X) and the content of component (Y) is preferably 0.001 or more, more preferably 0.005 or more. More preferably 0.008 or more, still more preferably 0.01 or more, preferably 200 or less, more preferably 150 or less, still more preferably 120 or less, still more preferably 100 or less. A method of removing any one of the above-mentioned [5] to [7].
  • the mass ratio (content of component (Y) in the free state / content of component (Y)) between the content of the component (Y) present in free form and the content of component (Y) is Any one of the above [5] to [8], preferably 0.6 or more, more preferably 0.8 or more, further preferably 0.9 or more, and further preferably 1.0. How to remove horn plugs.
  • the composition further contains an anionic surfactant (A), and preferably the component (A) is an anionic surfactant (A1) having a carboxylic acid group and / or a sulfonic acid group or a sulfate ester.
  • Component (A1) preferably contains one or more selected from fatty acids or salts thereof, ether carboxylic acids or salts thereof, and N-acyl amino acid salts
  • component (A2) is preferably alkylbenzene Sulfonic acid or its salt, alkane sulfonic acid or its salt, alkenyl sulfonic acid or its salt, alkyl sulfonic acid or its salt, acyl isethionic acid or its salt, alkyl sulfate or its salt, alkyl ether sulfate or its salt, alkyl sulfosuccinate
  • the mass ratio ((X) / (A1)) between the content of component (X) and the content of component (A1) is preferably 0.1 or more, more preferably 0.5 or more. Yes, more preferably 1.0 or more, and preferably 100 or less, more preferably 80 or less, still more preferably 70 or less.
  • the component (X) is the component (X1) or ( In any case of X2), it is more preferably 2 or more, further preferably 5 or more, more preferably 8 or more, further preferably 60 or less, more preferably 50 or less, More preferably, it is 40 or less, more preferably 30 or less, further preferably 20 or less, and when component (X) is only component (X3), it is more preferably 2 or more, and further preferred.
  • Ku is 5 or more, still more preferably 8 or more, more preferably 15 or more, more preferably 30 or more, more preferably 40 or more.
  • the mass ratio ((X) / (A2)) is preferably 0.005 to 100, more preferably 0.01 to 60, still more preferably 0.10 to 50, and still more preferably. 0.20 to 40, more preferably 0.20 to 30, more preferably 0.20 to 20, further preferably 0.25 to 15, and more preferably 0.3 to 14.
  • the content of the component (A1) in the composition is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and further preferably 0.10% by mass or more. More preferably 0.3% by mass or more, preferably 5% by mass or less, more preferably 3% by mass or less, still more preferably 2.0% by mass or less, and further preferably 1% or less. 0.5% by mass or less, more preferably 1.0% by mass or less, or the content of the component (A2) is preferably 0.01% by mass or more, more preferably 0.03% by mass. Yes, more preferably 0.05% by mass or more, further preferably 0.10% by mass or more, preferably 20% by mass or less, more preferably 18% by mass or less, even more preferable.
  • component (X) when component (X1) or component (X2), it is more preferably at least 0.2, more preferably at least 0.3% by mass. More preferably, it is 0.5% by mass or more. Further, it is more preferably 12% by mass or less, further preferably 10% by mass or less, further preferably 8% by mass, further preferably 5% by mass or less, and further preferably 4% by mass or less.
  • component (X) is only the component (X3), it is preferably 0.2 or more, more preferably 0.3% by mass or more, and further preferably 0.5% by mass. % Or more, more preferably 1.0% by mass or more, further preferably 1.5% by mass or more, and further preferably 2.0% by mass or more.
  • the total content of component (A) is preferably 0.01% by mass or more, more preferably 0.02% by mass or more, and further preferably 0.05% by mass or more in the composition.
  • the content of the anionic surfactant other than components (A1) and (A2) is preferably 0.01% by mass or more, more preferably 0.05% by mass or more in the composition.
  • the content is 0.1% by mass or more, preferably 10% by mass or less, more preferably 5% by mass or less, still more preferably 1.0% by mass or less, and still more preferably 0.8%.
  • the composition further contains a nonionic surfactant (B), preferably a nonionic surfactant (B1) of HLB11 or higher and / or a nonionic interface of less than HLB11 as the component (B).
  • B nonionic surfactant
  • the component (B1) is preferably polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil fatty acid ester, And at least one selected from alkyl polyglucosides, more preferably at least one selected from polyethylene glycol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene sorbitan fatty acid esters, and alkyl polyglucosides.
  • the method of removing the square plug of said [16] containing is preferably polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil fatty acid ester, And at least one selected from alkyl polyglucosides, more preferably
  • component (B2) preferably contains one or more selected from polyoxyethylene alkyl ether and polyglycerin fatty acid ester.
  • the content of component (B) in the composition is preferably 0.1% by mass or more, more preferably 0.4% by mass or more, and more preferably 0.5% by mass or more. Yes, preferably 30% by mass or less, more preferably 25% by mass or less, further preferably 20% by mass or less, further preferably 15% by mass or less, and further preferably 10% by mass or less.
  • the mass ratio ((B1) / (B2)) of the content of the component (B1) and the content of the component (B2) is preferably 0.1 or more, more preferably 0.6 or more. More preferably 0.8 or more, further preferably 1.5 or more, further preferably 2.5 or more, further preferably 5 or more, and preferably 25 or less, more
  • the mass ratio ((X) / (B)) of the content of component (X) to the content of component (B) is preferably 0.01 or more, more preferably 0.1 or more.
  • the composition further contains an amphoteric surfactant (C), and the content of the component (C) is preferably 0.1% by mass or more in the composition, more preferably 0.8%. 5% by mass or more, more preferably 1% by mass or more, preferably 15% by mass or less, more preferably 10% by mass or less, and further preferably 5% by mass or less [1] [21] A method for removing any one of the square plugs.
  • the composition further contains a polyol (D), and the content of the component (D) is preferably 0.5% by mass or more, more preferably 1% by mass or more in the composition. More preferably 3% by mass or more, further preferably 5% by mass or more, further preferably 8% by mass or more, 10% by mass or more, preferably 40% by mass or less, more preferably Is 35% by mass or less, more preferably 30% by mass or less, further preferably 25% by mass or less, and further preferably 20% by mass or less, and any one of the above [1] to [22] How to remove the plug.
  • Component (D) is preferably ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, isoprene glycol, hexylene glycol, 1,3-butylene glycol, glycerin, diglycerin, triglycerin 1 selected from tetraglycerin, hexaglycerin, decaglycerin, trimethylpropanol, erythritol, pentaerythritol, dipentaerythritol, glucose, mannose, galactose, sucrose, fructose, maltose, maltitol, xylitol, inositol, sorbitan and sorbitol Including two or more species, more preferably dipropylene glycol, 1,3-butylene glycol, Glycerin, including one or two kinds selected from sorbitol and mannitol,
  • the composition further contains a water-soluble polymer (E), and the content of the component (E) is preferably 0.01% by mass or more in the composition, more preferably 0.8%.
  • 05 mass% or more more preferably 0.10 mass% or more, further preferably 0.15 mass% or more, preferably 3 mass% or less, more preferably 2 mass% or less. Yes, more preferably 1.0% by mass or less, more preferably 0.8% by mass or less.
  • the component (E) is one or more selected from a carboxyvinyl polymer, a copolymer of acrylic acid / alkyl (meth) acrylate, and a cellulose to which a hydroxyethyl group or a hydroxypropyl group is added.
  • the composition further contains one or more (F) selected from neutral amino acids, betaine type compounds and ethylenediamine tetraacetate, and the content of such component (F) is contained in the composition. , Preferably 0.1% by mass or more, more preferably 0.5% by mass or more, further preferably 1.0% by mass or more, and preferably 20% by mass or less, more preferably A method for removing a square plug according to any one of the above [1] to [26], which is 15% by mass or less, more preferably 10% by mass or less.
  • Component (F) preferably contains one or more selected from trimethylglycine, trimethylserine, hydroxyethyldimethylglycine and monoethanol-C5-carboxybetaine, more preferably trimethylglycine, trimethylserine
  • the method for removing a horn plug comprising one or more selected from hydroxyethyldimethylglycine, and more preferably trimethylglycine.
  • the composition contains water (G), and the content of the component (G) is preferably 10% by mass or more, more preferably 20% by mass or more, and further preferably 30% by mass.
  • the pH at 25 ° C. of the composition when containing any one of component (X) alone is preferably 8.5 or more, and preferably 12.5 or less.
  • the pH at 25 ° C. of the composition when 2-amino-2-hydroxymethyl-1,3-propanediol (X1) is contained alone as component (X) is preferably 8.6. Or more, more preferably 8.8 or more, still more preferably 9.0 or more, still more preferably 9.2 or more, still more preferably 9.3 or more, and further preferably 9.5.
  • the composition when 2-amino-2-methyl-1-propanol (X2) is contained alone as component (X) is preferably 9.0 or more, More preferably, it is 9.2 or more, More preferably, it is 9.3 or more, More preferably, it is 9.5 or more, More preferably, it is 9.8 or more, More preferably, it is 10.0 or more, More preferably, it is 10.2 or more, More preferably, it is 10.5 or more, Preferably it is 12.5 or less, More preferably, it is 12.2 or less, More preferably, it is 12.0 or less,
  • the above [1] to [30] are preferably 11.8 or less, more preferably 11.5 or less, further preferably 11.2 or less, and further preferably 11.0 or less.
  • the pH at 25 ° C. of the composition is preferably 8.5 or more More preferably, it is 8.8 or more, More preferably, it is 9.0 or more, More preferably, it is 9.2 or more, More preferably, it is 9.3 or more, More preferably, it is 9.5 or more More preferably, it is 9.8 or more, More preferably, it is 10.0 or more, Preferably it is 12.5 or less, More preferably, it is 12.2 or less, More preferably, it is 12.0 or less More preferably 11.8 or less, further preferably 11.5 or less, further preferably 11.2 or less, and further preferably 11 or less.
  • the pH at 25 ° C. of the composition when containing two or more selected from the above components (X1) to (X3) as component (X) is preferably 8.3 or more, more preferably Is 8.5 or more, more preferably 8.8 or more, still more preferably 9.0 or more, still more preferably 9.2 or more, further preferably 9.3 or more, and further preferably Is a method of removing a square plug according to any one of [1] to [29] above, which is 9.5 or more, more preferably 9.8 or more, and further preferably 10.0 or more.
  • the composition containing component (X) and component (Y) is preferably 8.3 or more, more preferably 8.5 or more, and even more preferably 8. It is 8 or more, More preferably, it is 9.0 or more, More preferably, it is 9.2 or more, More preferably, it is 9.3 or more, More preferably, it is 9.5 or more, More preferably, it is 9. 8 or more, more preferably 10.0 or more, preferably 12.5 or less, more preferably 12.2 or less, further preferably 12.0 or less, and further preferably 11.8.
  • the square plug according to any one of the above [5] to [8] is removed, more preferably 11.5 or less, further preferably 11.2 or less, and further preferably 10.0 or less.
  • Method. [36] The above [1] to [35], wherein the composition is preferably a foam, liquid, paste, or cream dosage form, more preferably a foam or liquid dosage form. How to remove the horn plug.
  • composition for promoting skin penetration comprising one or more (X) selected from propanediol (X3).
  • Step (I) of preheating water to 60 to 80 ° C. Step of sequentially adding component (X) and other components as necessary to the water obtained in step (I), mixing and stirring
  • [54] A step of containing an acidic component in the composition and mixing each component containing an acidic component other than the component (X) in the step (II), and mixing and stirring to dissolve each component (II1) Then, the step (II2) of neutralizing the acidic component by adding a neutralizing agent, and the step (II3) of adding the component (X) and, if necessary, the component (Y), mixing and stirring to dissolve, The manufacturing method of the composition of said [53]. [55] The method for producing a composition according to [54], wherein the neutralizing agent is one or two selected from sodium hydroxide and potassium hydroxide.
  • [56] A step of containing an acidic component in the composition and mixing each component containing an acidic component other than the component (X) in the step (II), and mixing and stirring to dissolve each component (II1 ′ ), And then the step (II2 ′) of adding the component (X) more than the amount of the component (X) necessary for neutralization of the acidic component and, if necessary, the component (Y), mixing and stirring to dissolve (II2 ′), [53] A method for producing the composition of [53].
  • the skin of the body more preferably the skin excluding the scalp such as the face, neck, limbs, or torso, more preferably the pores on these skins, more preferably the face forehead.
  • a method of using the composition wherein the composition according to any one of the above [43] to [47] is applied to a pore site on the skin from the tip of the nose to the tip of the nose and then rinsed with water or wiped with a wiping material after a certain period of time.
  • [58] Massage at the application site for 10 seconds to 10 minutes, preferably 15 seconds to 5 minutes, more preferably 30 seconds to 4 minutes, more preferably 1 to 3 minutes, and then remove the composition remaining on the application site with water.
  • [66] It contains any two or more of component (X), the pH of the composition at 25 ° C. is from 8.3 to 12.5, and the total content of component (X) in the composition is 5 A method of removing any one of the above-mentioned [1] to [36], [48] and [59] to [65], which is not less than 10% by mass and not more than 10% by mass, or use for removing the corner plug.
  • the component (X1) is contained, the pH of the composition at 25 ° C.
  • [71] It contains component (X2), the pH of the composition at 25 ° C. is from 9.0 to 12.5, and the content of component (X) in the composition is from 0.08 mass% to 35 mass% % Or less of any one of the above [1] to [36], [48] and [59] to [70], or a method for removing the horn plug.
  • the component (X2) is contained, the pH of the composition at 9.0C is from 9.0 to 12.5, and the content of the component (X) in the composition is from 1.0% by mass to 20% by mass % Or less of any one of the above [1] to [36], [48] and [59] to [71], or a method for removing the horn plug.
  • One type selected from component (X1) and component (X2) and component (X3), the content of component (X3) and the total content of component (X1) and component (X2) Mass ratio ((X3) / ((X1) + (X2))) is 0.001 or more and 100 or less, and the pH of the composition at 25 ° C. is 8.5 or more and 12.5 or less.
  • the square plug of any one of [1] to [36], [48] and [59] to [78] above, in which the content of component (X) is 0.08% by mass or more and 35% by mass or less is removed. Method or use to remove horn plugs.
  • One type selected from component (X1) and component (X2) and component (X3), the content of component (X3) and the total content of component (X1) and component (X2) Mass ratio ((X3) / ((X1) + (X2))) is 0.08 or more and 20 or less, and the pH of the composition at 25 ° C. is 8.5 or more and 12.5 or less, A method for removing the square plug of any one of the above [1] to [36], [48] and [59] to [80], wherein the content of the component (X) in is from 3% by mass to 12% by mass; Or use to remove horn plugs.
  • One type selected from the component (X1) and the component (X2) and the component (X3), the content of the component (X3) and the total content of the component (X1) and the component (X2) Mass ratio ((X3) / ((X1) + (X2))) is 0.10 or more and 10 or less, and the pH of the composition at 25 ° C. is 8.5 or more and 12.5 or less.
  • Example 1 Samples having the formulations shown in Tables 1-19 were prepared. Specifically, water can be heated in advance to 70 ° C., the remaining components are sequentially added, mixed and stirred, and the resulting mixture is cooled to 20 ° C. to obtain. The results are shown in Tables 1 to 19. The pH of the obtained sample was measured at 25 ° C. using a pH meter (manufactured by Horiba, model number F-22).
  • the state of contact between the plug and the sample is recorded with a digital microscope (VHX-5000; Keyence, 150 times magnification), and the sample penetrates into the plug after 1 minute has passed after the contact with the sample. Evaluation was made on the sex and the state of collapse of the horn plug. The respective evaluation results are described in the table as “square plug cleaning power (permeability)” and “square plug cleaning power (during cleaning)”. The measurement was performed at 25 ° C. The evaluation criteria for penetrability are 1 for "the sample hardly penetrates into the plug" and 11 for "the sample penetrates to the center of the plug”. It was.
  • the criterion for evaluating the degradability of the square plug detergency is 1 in which “there is almost no change in the appearance of the square plug”, and “there is peeling / separation from the surface of the square plug to the center thereof (the external appearance of the square plug). Does not retain the initial form) ”state was set to 11, and the 11-stage relative evaluation.
  • (Criteria) 5 The boundary between the model sebum application part and the non-application part is not visible at all. 4: The boundary between the model sebum application part and the non-application part is partially faint. 3: The entire boundary between the model sebum application part and the non-application part looks very thin. 2: The entire boundary between the model sebum application part and the non-application part appears thin. 1: The entire boundary between the model sebum application part and the non-application part is clearly visible.
  • a foundation (Sofina Prima Vista (registered trademark) Liquid Foundation Ocher 05; manufactured by Kao Co., Ltd.) was uniformly applied to the inside of the forearm with a diameter of 3 cm and dried for 15 minutes.
  • a sample of 1.0 mL was applied to the foundation application part, massaged for 30 seconds, and then rinsed with tap water (water amount of rinse water: 1000 mL / 10 seconds, water temperature: 25 to 30 ° C.) for 30 seconds.
  • the residual amount of foundation on the skin after rinsing was visually observed and evaluated according to the following criteria.
  • (Criteria) 5 The boundary between the foundation application part and the non-application part is not visible at all. 4: The boundary between the foundation application portion and the non-application portion is partially faint. 3: The entire boundary between the foundation application part and the non-application part looks very thin. 2: The entire boundary between the foundation application part and the non-application part appears thin. 1: The entire boundary between the foundation application part and the non-application part is clearly visible.
  • the horn plug did not collapse, and the plug cleaning ability was hardly expressed. Furthermore, when the horn plug was brought into contact with water for 1 minute, the horn plug contacted with Tris, AMP or AMPD was further swollen, and a phenomenon was observed in which the horn plug was further collapsed. On the other hand, in the horn plugs contacted with disodium hydrogen phosphate, trisodium phosphate, or sodium hydrogen carbonate, the horn plugs did not swell even when contacted with water, and the horn plugs did not collapse.
  • the horn plug cleaning power score at the time of washing is preferably 3 or more, and the horn plug washing power score at the time of washing is 5 or more. If so, it is more preferable because the decay of the horn plug increases during washing and the horn plug can be removed more quickly.
  • Example 2 The following face wash was prepared. Specifically, water can be heated in advance to 70 ° C., the remaining components are sequentially added, mixed and stirred, and the resulting mixture can be cooled to 25 ° C. to obtain.
  • the following facial cleansers were used to evaluate the effect of improving the square plug detergency (at the time of washing) and skin color brightness.
  • the difference of the average brightness value of the internal scattered light on the 0th day is calculated from the average brightness value of the internal scattered light after use on the 7th, 14th, and 21st days, and the 7th, 14th, 21st of each group is calculated.
  • the average change amount of the average luminance value of each internally scattered light after the day use is calculated and shown in FIG.
  • the sample use group showed a tendency that the brightness of the skin was improved as compared with the general face wash use group.

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US16/604,019 US11406576B2 (en) 2017-04-10 2018-04-09 Method for removing keratotic plugs
EP18784620.9A EP3610849B1 (en) 2017-04-10 2018-04-09 Method for removing keratotic plugs
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US11633335B2 (en) * 2017-04-10 2023-04-25 Kao Corporation Skin cleansing composition
JP2024016867A (ja) * 2022-07-27 2024-02-08 株式会社ナリス化粧品 ふき取り化粧水用組成物
JP7492557B2 (ja) 2022-07-27 2024-05-29 株式会社ナリス化粧品 ふき取り化粧水用組成物
WO2024110854A1 (zh) 2022-11-24 2024-05-30 花王株式会社 皮肤清洁剂组合物
EP4623894A1 (en) 2022-11-24 2025-10-01 Kao Corporation Skin cleanser composition

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