WO2018090200A1 - Procédé de préparation d'isophorone - Google Patents

Procédé de préparation d'isophorone Download PDF

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Publication number
WO2018090200A1
WO2018090200A1 PCT/CN2016/105940 CN2016105940W WO2018090200A1 WO 2018090200 A1 WO2018090200 A1 WO 2018090200A1 CN 2016105940 W CN2016105940 W CN 2016105940W WO 2018090200 A1 WO2018090200 A1 WO 2018090200A1
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WO
WIPO (PCT)
Prior art keywords
isophorone
organic
quaternary ammonium
urotropine
strong base
Prior art date
Application number
PCT/CN2016/105940
Other languages
English (en)
Chinese (zh)
Inventor
周章涛
徐俊烨
费安杰
谭传文
黄志宁
肖诗华
颜燕南
Original Assignee
广东莱佛士制药技术有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 广东莱佛士制药技术有限公司 filed Critical 广东莱佛士制药技术有限公司
Priority to PCT/CN2016/105940 priority Critical patent/WO2018090200A1/fr
Publication of WO2018090200A1 publication Critical patent/WO2018090200A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/603—Unsaturated compounds containing a keto groups being part of a ring of a six-membered ring

Definitions

  • the invention relates to the technical field of organic chemical synthesis, in particular to a preparation method for catalytic synthesis of isophorone.
  • Isophorone (CAS: 78-59-1) is an important fine chemical raw material. It has a wide range of applications in the polymer industry and the pharmaceutical industry, with an annual output of tens of thousands of tons.
  • the compound was synthesized in the 19th century and began industrialization during the rapid development of the polymer industry in the 1960s. Then, with the worldwide demand for high-performance materials, pharmaceutical intermediates, pesticides and other industries, its market is fast. Growth, the current annual demand is up to tens of thousands of tons.
  • the current industrial production routes of isophorone are acetone condensation methods, which are specifically classified into liquid phase condensation and gas phase condensation.
  • the liquid phase condensation reported in the literature is a high pressure vessel in which a strong inorganic base such as sodium amide, calcium hydride, alkali metal or alkaline earth metal hydroxide is used as a catalyst and heated to a high temperature for condensation. Since the inorganic strong base is not easily soluble in acetone, in order to make the reaction proceed smoothly, a small amount of water is generally added. Since the reaction condensate is insoluble in water, the system gradually forms two phases, requiring intense stirring. The disadvantage of this type of synthesis is the low conversion rate and selectivity.
  • the gas phase condensation reported in the literature is that at a high temperature, acetone gas is reacted at a high temperature (200-300 degrees Celsius) through a solid phase catalyst such as a metal oxide, a metal hydroxide, a calcium aluminum composite, or a magnesium aluminum composite.
  • a solid phase catalyst such as a metal oxide, a metal hydroxide, a calcium aluminum composite, or a magnesium aluminum composite.
  • the advantage of this type of synthesis is that the conversion and selectivity are slightly better.
  • the disadvantages are high energy consumption, high catalyst preparation cost, and short catalyst life.
  • the present invention provides a method for preparing isophorone by using an organic urotropine quaternary ammonium base.
  • the catalyst is subjected to liquid phase synthesis of isophorone.
  • the invention relates to a method for preparing an organic catalyzed isophorone.
  • the acetone is used as a starting material, and under the catalysis of a quaternary ammonium strong base of a catalyst organic urotropine, a liquid phase condensation reaction of acetone is carried out, and isophorone is obtained by distillation. Specifically, the following steps are included:
  • Step (1) in said X - is a quaternary ammonium salt anion hexamine, including Cl -, Br -, I - A; reaction solvent in step (1) used in the next reaction as a starting Acetone.
  • the reaction solvent of the step (1) is the starting material of the reaction of the step (2), and the influence of other solvents and the reaction substrate can be avoided.
  • the base used in the step (1) is sodium hydroxide, sodium methoxide, sodium ethoxide or sodium t-butoxide, and preferably sodium methoxide.
  • the temperature of the exchange reaction is 0 to 30 ° C, preferably 10 to 20 ° C; and the exchange reaction time is 1 to 8 h, preferably 2 to 4 h.
  • organic urotropine quaternary ammonium strong base of the above condensation reaction has the following structure:
  • R in the formula is an aliphatic chain substituent of less than or equal to 6 carbons, or a benzyl group.
  • the organic urotropine quaternary ammonium strong base can be dissolved in the acetone as the reaction medium and the starting material, so that the reaction can proceed smoothly without adding water, and the reaction condensate is insoluble in water, and the system gradually forms two phases, which requires strong The technical problem of stirring. At the same time, the conversion and selectivity of the condensation reaction are improved due to the overall reaction of the organic urolotine quaternary ammonium strong base and the reactants.
  • the R is a methyl group, an ethyl group, a n-propyl group, an isopropyl group, a t-butyl group, an n-butyl group, or a benzyl group.
  • the reaction medium and the starting material are both acetone, and the catalytic organic urotropine quaternary ammonium strong base is used in a catalytic amount of 0.1 to 10 mol%, and the condensation reaction is carried out in an autoclave, and the condensation reaction is carried out.
  • the temperature is 140 to 180 ° C, and the condensation reaction time is 5 to 24 hours.
  • the purification of isophorone can be carried out continuously or intermittently, in a single stage or in multiple stages. Purification is preferably achieved by distillation, which is isolated and purified according to the difference in boiling point of the main product isophorone and by-products to give isophorone.
  • the catalytic organic urotropine quaternary ammonium strong base is added in a catalytic amount of 0.5 to 2 mol%, the condensation reaction is carried out in an autoclave, and the condensation reaction temperature is 150 to 170 ° C, and the condensation reaction is carried out. The time is 7 to 12 hours.
  • the preparation method of isophorone provided by the invention adopts organic catalytic synthesis, single conversion rate is more than 50%, selectivity is more than 60%, novel process, less steps, mild reaction conditions and the like.
  • acetone and an organic urotropine quaternary ammonium strong base are subjected to a condensation reaction in the same solvent system, and after the reaction is carried out at a controlled temperature for a certain period of time, the selectivity of isophorone is substantially stabilized, and the reaction is formed.
  • the product is small, substantially no multi-polymerized product, and the reaction is easier to control, and the end point of the reaction is not strictly controlled; finally, the main product isophorone is obtained by distillation and separation and purification.
  • the autoclave was installed, heated to 150 ° C and reacted for 6 hours. After cooling, the sample was taken for GC analysis, and the acetone conversion rate was 59%, and the selectivity was 65%. After removing acetone by atmospheric distillation, the product was subjected to vacuum distillation to obtain 26 g of isophorone in a yield of 36%.
  • the autoclave was installed, heated to 160 ° C and reacted for 7 hours. After cooling, the sample was taken for GC analysis, and the acetone conversion rate was 60%, and the selectivity was 66%. After removing acetone by atmospheric distillation, the product was subjected to vacuum distillation to obtain 27 g of isophorone in a yield of 38%.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé de préparation d'isophorone par catalyse organique. L'acétone est utilisée en tant que matériau de départ, et subit une réaction de condensation en phase liquide sous l'action catalytique d'un catalyseur, c'est-à-dire, une base forte d'ammonium quaternaire à base d'urotropine organique, de telle sorte que l'isophorone est obtenue par distillation. Le procédé comprend plus particulièrement, la synthèse de la base forte d'ammonium quaternaire à base d'urotropine organique et la synthèse de l'isophorone. La base forte d'ammonium quaternaire à base d'urotropine organique est dissoluble dans l'acétone servant de milieu de réaction et de matériau de départ, de telle sorte que la réaction peut avoir lieu avec souplesse. En utilisant le procédé de préparation d'isophorone fourni par la présente invention, l'isophorone est synthétisée, et le procédé de synthèse utilise une catalyse organique, de sorte qu'une conversion par passe soit supérieure à 50 %, et la sélectivité est supérieure à 60 %. Le procédé de préparation d'isophorone selon la présente invention présente un nouveau procédé, quelques étapes et des conditions de réaction modérées.
PCT/CN2016/105940 2016-11-15 2016-11-15 Procédé de préparation d'isophorone WO2018090200A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/105940 WO2018090200A1 (fr) 2016-11-15 2016-11-15 Procédé de préparation d'isophorone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/105940 WO2018090200A1 (fr) 2016-11-15 2016-11-15 Procédé de préparation d'isophorone

Publications (1)

Publication Number Publication Date
WO2018090200A1 true WO2018090200A1 (fr) 2018-05-24

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1357435A (en) * 1970-10-07 1974-06-19 Basf Ag Production of alkoxyacetaldehydes and acyloxyacetaldehydes
US5202496A (en) * 1989-04-18 1993-04-13 Aristech Chemical Corporation Method of making isophorne
CN104988510A (zh) * 2015-07-20 2015-10-21 武汉工程大学 一种乌洛托品季铵盐缓蚀剂及其制备方法和应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1357435A (en) * 1970-10-07 1974-06-19 Basf Ag Production of alkoxyacetaldehydes and acyloxyacetaldehydes
US5202496A (en) * 1989-04-18 1993-04-13 Aristech Chemical Corporation Method of making isophorne
CN104988510A (zh) * 2015-07-20 2015-10-21 武汉工程大学 一种乌洛托品季铵盐缓蚀剂及其制备方法和应用

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