WO2018088875A3 - 외래 미토콘드리아를 포함하는 자연살해세포 및 이를 포함하는 약학적 조성물 - Google Patents

외래 미토콘드리아를 포함하는 자연살해세포 및 이를 포함하는 약학적 조성물 Download PDF

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Publication number
WO2018088875A3
WO2018088875A3 PCT/KR2017/012883 KR2017012883W WO2018088875A3 WO 2018088875 A3 WO2018088875 A3 WO 2018088875A3 KR 2017012883 W KR2017012883 W KR 2017012883W WO 2018088875 A3 WO2018088875 A3 WO 2018088875A3
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pbmc
cells
mitochondrium
pharmaceutical composition
same
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PCT/KR2017/012883
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English (en)
French (fr)
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WO2018088875A2 (ko
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한규범
이영준
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주식회사 파이안에스테틱스
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Priority to CN201780070481.5A priority Critical patent/CN109983120A/zh
Priority to RU2019118070A priority patent/RU2777371C2/ru
Priority to EP17869358.6A priority patent/EP3540048A4/en
Priority to JP2019525738A priority patent/JP7074358B2/ja
Priority to US16/349,310 priority patent/US11278569B2/en
Publication of WO2018088875A2 publication Critical patent/WO2018088875A2/ko
Publication of WO2018088875A3 publication Critical patent/WO2018088875A3/ko
Priority to US17/483,193 priority patent/US20220000930A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma

Abstract

본 발명은 세포독성이 증가한 NK 세포 및 PBMC에 대한 것이다. 특히, 외래 미토콘드리아가 도입된 NK 세포 및 PBMC는 인체의 면역 체계를 강화하여 감염질환이나 암에 대한 치료효과를 증진시켜준다. 따라서, 상기 NK세포 및 PBMC를 포함하는 감염질환 및 암 예방 또는 치료용 조성물로 사용될 수 있다. 특히, 상기 NK 세포 및 PBMC가 자가 유래의 세포일 경우 면역반응을 유발하지 않아 안정성이 확보되는 바 상업적으로 활용가능성이 높을 것으로 기대된다.
PCT/KR2017/012883 2016-11-14 2017-11-14 외래 미토콘드리아를 포함하는 자연살해세포 및 이를 포함하는 약학적 조성물 WO2018088875A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201780070481.5A CN109983120A (zh) 2016-11-14 2017-11-14 含有外源线粒体的天然杀伤细胞和含有其的药物组合物
RU2019118070A RU2777371C2 (ru) 2016-11-14 2017-11-14 Клетка-естественный киллер, содержащая экзогенную митохондрию, и фармацевтическая композиция, включающая такую клетку
EP17869358.6A EP3540048A4 (en) 2016-11-14 2017-11-14 NATURAL KILLER CELLS WITH EXOGENIC MITOCHONDRIUM AND PHARMACEUTICAL COMPOSITION THEREFOR
JP2019525738A JP7074358B2 (ja) 2016-11-14 2017-11-14 外因性ミトコンドリアを含むナチュラルキラー細胞および同細胞を含む医薬組成物
US16/349,310 US11278569B2 (en) 2016-11-14 2017-11-14 Natural killer cell containing exogenous mitochondrium and pharmaceutical composition comprising same
US17/483,193 US20220000930A1 (en) 2016-11-14 2021-09-23 Natural killer cell containing exogenous mitochondrium and pharmaceutical composition comprising same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160151411 2016-11-14
KR10-2016-0151411 2016-11-14

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/349,310 A-371-Of-International US11278569B2 (en) 2016-11-14 2017-11-14 Natural killer cell containing exogenous mitochondrium and pharmaceutical composition comprising same
US17/483,193 Continuation US20220000930A1 (en) 2016-11-14 2021-09-23 Natural killer cell containing exogenous mitochondrium and pharmaceutical composition comprising same

Publications (2)

Publication Number Publication Date
WO2018088875A2 WO2018088875A2 (ko) 2018-05-17
WO2018088875A3 true WO2018088875A3 (ko) 2018-08-09

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PCT/KR2017/012883 WO2018088875A2 (ko) 2016-11-14 2017-11-14 외래 미토콘드리아를 포함하는 자연살해세포 및 이를 포함하는 약학적 조성물

Country Status (7)

Country Link
US (2) US11278569B2 (ko)
EP (1) EP3540048A4 (ko)
JP (1) JP7074358B2 (ko)
KR (2) KR101846464B1 (ko)
CN (1) CN109983120A (ko)
RU (1) RU2021134402A (ko)
WO (1) WO2018088875A2 (ko)

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* Cited by examiner, † Cited by third party
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KR20200071338A (ko) 2018-12-11 2020-06-19 주식회사 스마트셀랩 Ｎｋ 세포 활성 조절을 통한 비만의 예방 또는 치료 방법
WO2021004477A1 (zh) * 2019-07-09 2021-01-14 唐凌峰 一种基于线粒体的药物递送系统及其用途
US20210309967A1 (en) * 2020-04-03 2021-10-07 Cellvie Inc. Enhancement of adoptive cell transfer
KR102290596B1 (ko) 2020-09-10 2021-08-19 주식회사 파이안바이오테크놀로지 분리된 미토콘드리아를 포함하는 주사용 조성물 및 이의 용도
KR102273163B1 (ko) 2020-09-10 2021-07-05 주식회사 파이안바이오테크놀로지 혈소판 유래 미토콘드리아의 수득 방법 및 이의 용도
CA3233989A1 (en) * 2021-10-06 2023-04-13 Nina DUMAUTHIOZ Enhancing adoptive cell transfer by promoting a superior population of adaptive immune cells
CN114699430A (zh) * 2022-04-12 2022-07-05 重庆理工大学 线粒体及其在胰腺炎中的应用和应用方法

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Also Published As

Publication number Publication date
CN109983120A (zh) 2019-07-05
US20220000930A1 (en) 2022-01-06
EP3540048A4 (en) 2020-06-24
US20190269731A1 (en) 2019-09-05
KR20180054523A (ko) 2018-05-24
RU2019118070A3 (ko) 2021-08-13
RU2019118070A (ru) 2020-12-14
WO2018088875A2 (ko) 2018-05-17
RU2021134402A (ru) 2022-01-14
EP3540048A2 (en) 2019-09-18
JP7074358B2 (ja) 2022-05-24
KR101846464B1 (ko) 2018-04-09
US11278569B2 (en) 2022-03-22
JP2019534029A (ja) 2019-11-28

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