EP3540048A4 - NATURAL KILLER CELLS WITH EXOGENIC MITOCHONDRIUM AND PHARMACEUTICAL COMPOSITION THEREFOR - Google Patents

NATURAL KILLER CELLS WITH EXOGENIC MITOCHONDRIUM AND PHARMACEUTICAL COMPOSITION THEREFOR Download PDF

Info

Publication number
EP3540048A4
EP3540048A4 EP17869358.6A EP17869358A EP3540048A4 EP 3540048 A4 EP3540048 A4 EP 3540048A4 EP 17869358 A EP17869358 A EP 17869358A EP 3540048 A4 EP3540048 A4 EP 3540048A4
Authority
EP
European Patent Office
Prior art keywords
mitochondrium
pharmaceutical composition
same
natural killer
cell containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17869358.6A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3540048A2 (en
Inventor
Kyuboem Han
Youngjun Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paean Biotechnology Inc
Original Assignee
Paean Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paean Biotechnology Inc filed Critical Paean Biotechnology Inc
Publication of EP3540048A2 publication Critical patent/EP3540048A2/en
Publication of EP3540048A4 publication Critical patent/EP3540048A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP17869358.6A 2016-11-14 2017-11-14 NATURAL KILLER CELLS WITH EXOGENIC MITOCHONDRIUM AND PHARMACEUTICAL COMPOSITION THEREFOR Pending EP3540048A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160151411 2016-11-14
PCT/KR2017/012883 WO2018088875A2 (ko) 2016-11-14 2017-11-14 외래 미토콘드리아를 포함하는 자연살해세포 및 이를 포함하는 약학적 조성물

Publications (2)

Publication Number Publication Date
EP3540048A2 EP3540048A2 (en) 2019-09-18
EP3540048A4 true EP3540048A4 (en) 2020-06-24

Family

ID=61977886

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17869358.6A Pending EP3540048A4 (en) 2016-11-14 2017-11-14 NATURAL KILLER CELLS WITH EXOGENIC MITOCHONDRIUM AND PHARMACEUTICAL COMPOSITION THEREFOR

Country Status (7)

Country Link
US (2) US11278569B2 (ko)
EP (1) EP3540048A4 (ko)
JP (1) JP7074358B2 (ko)
KR (2) KR101846464B1 (ko)
CN (1) CN109983120A (ko)
RU (1) RU2021134402A (ko)
WO (1) WO2018088875A2 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200071338A (ko) 2018-12-11 2020-06-19 주식회사 스마트셀랩 Ｎｋ 세포 활성 조절을 통한 비만의 예방 또는 치료 방법
CN114786685A (zh) * 2019-07-09 2022-07-22 唐凌峰 一种基于线粒体的药物递送系统及其用途
CN116096861A (zh) * 2020-04-03 2023-05-09 赛立维公司 过继性细胞转移的增强
KR102290596B1 (ko) 2020-09-10 2021-08-19 주식회사 파이안바이오테크놀로지 분리된 미토콘드리아를 포함하는 주사용 조성물 및 이의 용도
KR102273163B1 (ko) 2020-09-10 2021-07-05 주식회사 파이안바이오테크놀로지 혈소판 유래 미토콘드리아의 수득 방법 및 이의 용도
CA3233989A1 (en) * 2021-10-06 2023-04-13 Nina DUMAUTHIOZ Enhancing adoptive cell transfer by promoting a superior population of adaptive immune cells
CN114699430A (zh) * 2022-04-12 2022-07-05 重庆理工大学 线粒体及其在胰腺炎中的应用和应用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846028B2 (en) * 2010-10-28 2014-09-30 The Invention Science Fund I, Llc Mitochondrial enhancement of cells
CN104204194B (zh) 2011-12-22 2018-08-03 财团法人牧岩生命工学研究所 生产自然杀伤细胞的方法、由该方法生产的自然杀伤细胞以及包含该自然杀伤细胞的用于治疗癌症和感染性疾病的组合物
BR112015003149A2 (pt) 2012-08-13 2017-08-08 Anthrogenesis Corp células natural killer e usos das mesmas.
CN104630149B (zh) * 2013-11-08 2018-08-21 中国科学院广州生物医药与健康研究院 外源线粒体导入到哺乳动物细胞中的方法
EP3169338A1 (en) * 2014-07-16 2017-05-24 INSERM - Institut National de la Santé et de la Recherche Médicale Methods for the intercellular transfer of isolated mitochondria in recipient cells
JP7015169B2 (ja) 2015-02-26 2022-02-02 ミノヴィア セラピューティクス リミテッド 機能性ミトコンドリアで富化された哺乳動物細胞

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANDRÉS CAICEDO ET AL: "Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications", STEM CELLS INTERNATIONAL, vol. 2017, 1 January 2017 (2017-01-01), US, pages 1 - 23, XP055696104, ISSN: 1687-966X, DOI: 10.1155/2017/7610414 *
ANDRÉS CAICEDO ET AL: "MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function", SCIENTIFIC REPORTS, vol. 5, no. 1, 13 March 2015 (2015-03-13), XP055696073, DOI: 10.1038/srep09073 *
MI JIN KIM ET AL: "Delivery of exogenous mitochondria via centrifugation enhances cellular metabolic function", SCIENTIFIC REPORTS, vol. 8, no. 1, 20 February 2018 (2018-02-20), XP055695889, DOI: 10.1038/s41598-018-21539-y *

Also Published As

Publication number Publication date
WO2018088875A2 (ko) 2018-05-17
RU2019118070A3 (ko) 2021-08-13
JP2019534029A (ja) 2019-11-28
US20190269731A1 (en) 2019-09-05
JP7074358B2 (ja) 2022-05-24
KR20180054523A (ko) 2018-05-24
EP3540048A2 (en) 2019-09-18
US20220000930A1 (en) 2022-01-06
RU2019118070A (ru) 2020-12-14
US11278569B2 (en) 2022-03-22
WO2018088875A3 (ko) 2018-08-09
CN109983120A (zh) 2019-07-05
RU2021134402A (ru) 2022-01-14
KR101846464B1 (ko) 2018-04-09

Similar Documents

Publication Publication Date Title
EP3540048A4 (en) NATURAL KILLER CELLS WITH EXOGENIC MITOCHONDRIUM AND PHARMACEUTICAL COMPOSITION THEREFOR
EP3523419A4 (en) COMPOSITIONS AND METHODS FOR PRESERVING CELL VITABILITY
EP3362075A4 (en) NATURAL KILLER CELLS AND ILC3 CELLS AND USES THEREOF
EP3240552A4 (en) Natural killer cells and uses thereof
EP3223856A4 (en) Methods and compositions for natural killer cells
EP3562492A4 (en) GENETICALLY MODIFIED NATURAL KILLER CELLS
ZA201702632B (en) Compositions comprising recombinant bacillus cells and an insecticide
EP3228648A4 (en) Copolycarbonate and composition containing same
SG11201609118RA (en) Modified natural killer cells and uses thereof
EP3215623A4 (en) Cells lacking b2m surface expression and methods for allogeneic administration of such cells
EP3149025A4 (en) Cell penetrating peptides and methods of making and using thereof
EP3490366A4 (en) METHOD AND COMPOSITIONS FOR GENE EXPRESSION IN PLANTS
EP3130345A4 (en) Peptide having fibrosis inhibitory activity and composition containing same
EP3324982A4 (en) HEMATOPOIETIC STEM CELLS EXPRESSING PD-L1 AND USES
EP3048127A4 (en) Copolycarbonate and composition containing same
EP3444270A4 (en) NEW NATURAL PROTEIN AND ITS APPLICATION
EP3297950A4 (en) STABLE BASIC ELECTROLYTE MATERIAL AND SOLVENT MATERIAL THEREWITH
EP3591038A4 (en) MESENCHYMATIC STEM CELL, AND PHARMACEUTICAL COMPOSITION
EP3191578A4 (en) Cells expressing apolipoprotein e and uses thereof
EP3067379A4 (en) Copolycarbonate and composition containing same
EP3305802A4 (en) NEW PEPTIDE AND COMPOSITION CONTAINING SAME
EP3580341A4 (en) MANIPULATED NATURAL KILLER (NK) CELLS AND COMPOSITIONS AND METHOD FOR THEREFORE
EP3487809A4 (en) STABLE ELECTROLYTE MATERIAL AND SOLVENT MATERIAL THEREFOR
EP3686274A4 (en) METHOD OF MANUFACTURING A NATURAL KILLER CELL AND USE THEREOF
EP3307284A4 (en) COMPOSITIONS AND METHOD FOR ENRICHMENT OF CELLS

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20190613

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20200528

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 35/17 20150101ALI20200520BHEP

Ipc: A61K 35/15 20150101ALI20200520BHEP

Ipc: A61K 9/08 20060101ALI20200520BHEP

Ipc: A61K 9/19 20060101ALI20200520BHEP

Ipc: C12N 5/0783 20100101AFI20200520BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20210726

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS