WO2018076567A1 - Multi-organ preservation apparatus - Google Patents

Multi-organ preservation apparatus Download PDF

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Publication number
WO2018076567A1
WO2018076567A1 PCT/CN2017/072740 CN2017072740W WO2018076567A1 WO 2018076567 A1 WO2018076567 A1 WO 2018076567A1 CN 2017072740 W CN2017072740 W CN 2017072740W WO 2018076567 A1 WO2018076567 A1 WO 2018076567A1
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Prior art keywords
organ
outlet
container
control valve
flow control
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PCT/CN2017/072740
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French (fr)
Chinese (zh)
Inventor
何晓顺
郭志勇
张林安
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中山大学附属第一医院
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Priority to JP2018600005U priority Critical patent/JP3223817U/en
Priority to DE212017000016.3U priority patent/DE212017000016U1/en
Publication of WO2018076567A1 publication Critical patent/WO2018076567A1/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts

Definitions

  • the present invention relates to a novel organ preservation system, and more particularly to a multi-organ preservation device.
  • organ transplantation The purpose of organ transplantation is to replace the organ that has lost its function due to a fatal disease, so that the transplanted individual can re-owned the corresponding organ and work normally.
  • transplant organs include kidney, heart, liver, pancreas and islets, parathyroid glands, heart and lung, bone marrow, and cornea.
  • the living organs required for organ transplantation are generally sourced from others, and the organs need to be cut from the source.
  • the isolated ischemic organs will die in a short period of time (less than a few minutes, and no more than one hour). Can not be used for transplantation, but it is impossible to complete the transplant in such a short time. Therefore, try to maintain the activity of the organ, and ensure that the organ leaves the source of the body to the organ transplant surgery.
  • the cryopreservation method is relatively common.
  • the low-temperature static preservation method reduces the organ energy consumption by low temperature, thereby prolonging the organ preservation time.
  • the low temperature intelligently slows down the cell death rate and cannot prevent cell death.
  • the low temperature may also cause damage to the tissue cells. .
  • Patent 201410384703.9 discloses a low-temperature or sub-normal temperature kidney preservation device which has begun to consider organ preservation at sub-normal temperature and improve the preservation quality of the kidney.
  • Patent 201410016261.2 discloses a device for preserving isolated organs and a preservation method which provides continuous nutrient and oxygen supply to isolated organs by means of mechanical perfusion and membrane oxygenation.
  • Patent 201510085562.5 discloses a safety protection enhanced organ cryo-machine perfusion preservation device that performs organ preservation at low temperatures while achieving different perfusion modes by various control signals of the pump.
  • Patent 201310723787.X discloses a transplant organ protection bag which is simple in structure, however, the device can only perform organ preservation at low temperatures, unable to supply oxygen and circulate blood. The above patents are only for the preservation of one organ and cannot store multiple or multiple organs at the same time.
  • the object of the present invention is to overcome the deficiencies of the prior art and to provide a multi-organ preservation device having a simple structure and good operability.
  • a multi-organ preservation device comprising a cart, on which a multi-organ preservation device is installed, the multi-organ preservation device comprising:
  • a water bath in which a multi-organ container is placed, and at least four compartments are provided in the multi-organ container, each compartment for placing different organs, all of the compartments
  • the bottom of the trough is connected to each other through a pipe, and a chute outlet is opened at the bottom of any one of the chutes, and a container cover is covered on the multi-organ container, and two sides are respectively passed on the front and rear sides of the container cover.
  • the symmetrically disposed container cover buckle is sealingly fastened with the multi-organ container, and the outer cover of the container cover is covered with an anti-bacterial cover, and the anti-bacterial cover is closely engaged with the multi-container cover by the anti-bacterial cover buckle.
  • a temperature sensor is installed in the water bath;
  • An oxygenation device the inlet of the oxygenation device is connected to the outlet of the peristaltic pump through a pipe, and the outlet of an oxygen cylinder is connected to the inlet of the oxygenation device through an oxygen conduit, the outlet of the oxygenation device and a
  • the conveying main pipes are connected, and the outlets of the plurality of drug pushers are respectively connected to the conveying main pipe through the drug pushing pipe, the outlet of the conveying main pipe is divided into a plurality of branches, and one branch is installed on each branch road.
  • An inlet flow control valve the outlet end of each of the branches passes through a water bath and a multi-organ container and is in communication with a tissue and art vessel in each of the plurality of organ containers, the outlet of the compartment being connected to the outlet conduit
  • the outlet conduit is passed through a water bath and a multi-organ container and is in communication with an outlet manifold that is connected to an outlet flow control valve, a filter, and an outlet of the peristaltic pump, the filtrate outlet of the filter being lower than the multi-organ container Liquid level in
  • At least 3 scaled organ secretion containers for collecting organ secretions, each organ container being connected to a corresponding secretion of an organ in each compartment of the multi-organ container by a secretion outlet conduit through a water bath, respectively On the pipeline;
  • a touch display screen the touch display screen is connected to the controller, and the control signal is outputted to the controller through the touch display screen, and the signal output by the controller is read and displayed, the controller and the peristaltic pump and the inlet a flow control valve, an outlet flow control valve, and a temperature sensor are respectively connected, and the controller reads the signal of the temperature sensor and according to the temperature
  • the signal output temperature control signal is sent to the water bath to heat the water in the water bath, and the controller reads the signals of the inlet flow control valve and the outlet flow control valve, and then outputs a rotation control signal to the peristaltic pump.
  • the multi-organ preservation device provided by the invention has the following beneficial effects:
  • the multi-organ preservation device of the invention has the advantages of simple structure, convenient operation, long-term preservation of the isolated organs, and even repair of the organs.
  • the multi-organ preservation device of the present invention can simultaneously store and repair organs such as liver, kidney, and pancreas, and can store up to four organs at the same time, thereby maximizing organ utilization.
  • the multi-organ preservation device of the present invention performs blood flow supply and flow control valve for flow rate and pressure regulation by controlling a peristaltic pump, and can ensure a proper blood flow supply during operation, and increase liver by supplying oxygen, drugs or nutrients. Save time and repair quality.
  • the multi-organ preservation device of the present invention intelligently controls the temperature of the water bath by the controller, thereby ensuring that the liver is preserved and repaired at a desired temperature, thereby maximally preventing damage to the liver caused by abnormal temperature.
  • the multi-organ preservation device of the present invention is in the form of a cart, which is convenient for doctors or related staff to move, flexible when taking organs, and can also be used as a training system for living experiments.
  • Figure 1 is a schematic view showing the principle of a multi-organ preservation device of the present invention
  • FIG. 2 is a schematic structural view of a multi-organ preservation device of a front view angle of the present invention
  • FIG. 3 is a schematic view showing the structure of a multi-organ preservation device of a rear view angle of the present invention.
  • the multi-organ preservation device of the present invention as shown in the accompanying drawings, including a cart, can be used by a worker to collect, transport, and perform some display and simple surgery throughout the process of organ collection and transportation. And experiment.
  • a multi-organ preservation device is installed on the cart, and the multi-organ preservation device includes:
  • a water bath 300 the water bath 300 can be applied with a commercial product or a customized product, the size of which is determined according to actual needs, in which a multi-organ container 108 is placed in the multi-organ container There are at least 4 compartments in the 108, each compartment for placing different organs. The bottoms of all the compartments are connected to each other through a pipe, and a compartment outlet is opened at the bottom of any one of the compartments, and a container cover 109 is covered on the multi-organ container 108, and the container cover is covered. The front and rear sides of the 109 are respectively sealed and fastened with the multi-organ container 108 by two symmetrically disposed container cover buckles 113 to ensure that the organ does not come out of the multi-organ container cover 109 during transportation.
  • An anti-bacterial cover 111 is disposed on the outside of the container cover 109, and the anti-bacterial cover 111 is closely engaged with the multi-container cover 108 by the anti-bacterial cover buckle 112 to prevent bacteria from entering the inside of the multi-organ container 108; a temperature sensor is installed in the water bath;
  • An oxygenation device 103 the inlet of the oxygenation device 103 is in communication with the outlet of the peristaltic pump 116 via a conduit, and the outlet of an oxygen cylinder 102 is in communication with the inlet of the oxygenation device 103 via an oxygen conduit.
  • the outlet of the oxygenation device 116 is connected to a delivery main pipe, and the outlets of the plurality of drug pushers 101 are respectively connected to the conveying main pipe through a drug pushing pipe, and the outlet of the conveying main pipe is divided into many a branch road, on each of which a inlet flow control valve 107-1 is installed, the outlet end of each of the branches passing through the water bath 300 and the multi-organ container 108 and in the respective tanks of the multi-organ container 108
  • the tissue and arteries are connected one by one, and the outlet of the compartment is in communication with an outlet duct that passes through the water bath 300 and the multi-organ container 108 and is sequentially connected with an outlet flow control valve 107-2, a filter 120 and an outlet manifold of the outlet of the peristaltic pump 116 are in communication.
  • the filter 120 installation should be slightly lower to ensure that the filter filtrate outlet is lower than the liquid level in the multi-organ container 108.
  • the inlet flow control valve can be used to control blood flow by manual or electric adjustment.
  • Corresponding secretion conduits (such as bile ducts secreting bile) in the organs in each compartment;
  • a touch display screen 105 is connected to the controller 200.
  • the touch display screen 105 outputs a control signal to the controller and reads and displays a signal output by the controller.
  • the controller 200 is provided. Connected to the peristaltic pump, the inlet flow control valve 107-1, the outlet flow control valve 107-2, and the temperature sensor, respectively, the controller 200 Reading the signal of the temperature sensor and outputting a temperature control signal to the water bath tank 300 according to the temperature signal to heat the water in the water bath, the controller 200 reads the inlet flow control valve 107-1 and the outlet flow control valve 107. The -2 signal is then output to the peristaltic pump.
  • the cart includes an upper platform 124 disposed on a bottom plate of the cart, and a handlebar 110 is fixed to the left side of the upper platform 124.
  • Four wheels 114 are connected to the upper side.
  • An intermediate partition 121 and a right partition 122 are respectively installed in the middle and the right side of the upper platform 124, and a plurality of drug pushers 101 (the number of the drug pushers 101 can be installed according to actual needs) and the oxygen cylinder 102 Installed on the upper platform 124 on the right side of the right side partition 122, the oxygen cylinder 102 is fixed to the right side partition plate 122 by the oxygen cylinder fixing belt 123 to ensure that the oxygen cylinder 102 is fixed.
  • the peristaltic pump 116, the oxygenation device and the filter 120 are arranged one behind the other between the intermediate partition 121 and the right partition 122, and the peristaltic pump 116 is fixed on the upper platform 124 and passes through the middle interval.
  • the plate 121 and the right side partition 122 are clamped to restrict the sway.
  • the oxygenation device 103 is suspended and fixedly connected to a U-shaped oxygenation device connecting plate 104, and the U-shaped ends of the oxygenation device connecting plate are respectively fixed on the intermediate partition 121 and the right partition plate 122.
  • the filter 120 is fixedly connected to the intermediate partition 121 through a filter holder 118, and the inlet flow control valve 107-1 is fixedly mounted on the top surface of the intermediate partition 121, the water bath box 300 is fixedly mounted on the upper platform 124 on the left side of the intermediate partition 121, and the organ secretion container 115 is mounted on the upper platform 124 on the front side of the multi-organ container 108.
  • the touch display screen 105 is fixed to the rear side of the upper platform 124 by the touch screen display connection bracket 106.
  • the inlet flow control valve and the outlet flow control valve adopt a mechanical manual valve or the inlet flow control valve and the outlet flow control valve adopt an electric control valve.
  • FIG. 4 is a schematic diagram of the principle of a multi-organ storage device. Each organ is stored in a multi-organ container 108. After the blood is powered by the peristaltic pump 116, the blood enters the oxygenation device 103, and the oxygen in the oxygen cylinder 102 enters the oxygenation device 116 to oxygenate the blood. . After the oxygenation, the blood flows into the organs, and the drug or nutrient which the drug pusher 101 pushes the liver mixes with the blood and enters each body. The blood flow and size entering each organ are controlled by respective inlet flow control valves 107-1, and the blood is returned to the filter 120 through the various organs, and the flow and pressure of the reflux are regulated by the outlet flow control valve 107-2.
  • the bubbles, impurities, and the like are filtered by the filter 120 and then returned to the peristaltic pump 116.
  • the pressure and flow sensors are clamped on the tubes of the blood flowing into the respective organs to measure the pressure, flow rate, and transmitted to the controller 200, and the temperature signals and the like in the water bath tank 300 are also connected to the controller 200 through sensors, and the controller 200 adjusts as needed.
  • the water temperature in the water bath 300 is adjusted while the rotational speed of the peristaltic pump 116 is adjusted according to various parameters and instructions from a doctor.
  • the doctor can perform the setting of the multi-organ preservation device by touching the display screen 105 and can see the operational status information of each component.

Abstract

Disclosed in the present invention is a multi-organ preservation apparatus, wherein a liver is deposited in a water bath tank, and different organs are stored by means of an independent multi-organ container; after being powered by a peristaltic pump, blood enters an oxygenation device, and oxygen in an oxygen bottle enters the oxygenation device to as to be fused with the blood. After blood oxygen reaches full oxygenation, a medicine pusher pushes a liver medicine or nutrient into a blood vessel for mixing with the blood, which then enter the various organs by means of arteries thereof. After passing through the various organs, the blood flows back to a filter, after bubbles and impurities and the like in the blood are filtered out by the filter, the blood then flows back to the peristaltic pump. The flow rate and flow speed of a flow inlet tube are controlled by means of a flow control valve. The present apparatus has a simple structure and convenient operations, and is capable of storing an ex-vivo organ for a long time.

Description

多器官保存装置Multiple organ preservation device 技术领域Technical field
本发明涉及一种新型器官保存系统，特别涉及一种多器官保存装置。The present invention relates to a novel organ preservation system, and more particularly to a multi-organ preservation device.
背景技术Background technique
器官移植的目的是代替因致命性疾病而丧失功能的器官，使被移植个体能重新拥有相应器官，并正常工作。常用的移植器官有肾、心、肝、胰腺与胰岛、甲状旁腺、心肺、骨髓、角膜等。在器官移植中所需要的活体器官一般来源与他人，器官需要从来源人体上切取下来，切取的离体缺血器官在短期内(少则几分钟，多则不超过1小时)就会死亡，不能用于移植，而要在如此短促的时间内完成移植手术是不可能的。因此，要设法保持器官的活性，保证在器官离开来源人体到器官移植手术中。The purpose of organ transplantation is to replace the organ that has lost its function due to a fatal disease, so that the transplanted individual can re-owned the corresponding organ and work normally. Commonly used transplant organs include kidney, heart, liver, pancreas and islets, parathyroid glands, heart and lung, bone marrow, and cornea. The living organs required for organ transplantation are generally sourced from others, and the organs need to be cut from the source. The isolated ischemic organs will die in a short period of time (less than a few minutes, and no more than one hour). Can not be used for transplantation, but it is impossible to complete the transplant in such a short time. Therefore, try to maintain the activity of the organ, and ensure that the organ leaves the source of the body to the organ transplant surgery.
目前比较常见的是低温保存方法，低温静态保存方法通过低温降低器官能耗，从而延长器官保存时间，然而低温智能减慢细胞死亡速度，不能防止细胞死亡，同时，低温也可能引起组织细胞的损害。At present, the cryopreservation method is relatively common. The low-temperature static preservation method reduces the organ energy consumption by low temperature, thereby prolonging the organ preservation time. However, the low temperature intelligently slows down the cell death rate and cannot prevent cell death. At the same time, the low temperature may also cause damage to the tissue cells. .
专利201410384703.9公开了一种低温或者亚常温的肾脏保存装置，其已经开始考虑在亚常温下进行器官保存，提高肾脏的保存质量。专利201410016261.2公开了一种保存离体器官的装置和保存方法，其通过机械灌注的方式及膜式氧合使离体器官得到持续的养分及氧气供应。。专利201510085562.5公开了一种安全防护增强型器官低温机器灌注保存装置，该装置在低温下进行器官保存，同时通过泵的各种控制信号实现不同的灌注模式。专利201310723787.X公开了一种移植器官保护袋，该装置结构简单，然而该装置也只能在低温下进行器官保存，无法提供氧气以及循环血液。以上专利只是针对一种器官进行保存，无法同时保存多个或者多种器官。Patent 201410384703.9 discloses a low-temperature or sub-normal temperature kidney preservation device which has begun to consider organ preservation at sub-normal temperature and improve the preservation quality of the kidney. Patent 201410016261.2 discloses a device for preserving isolated organs and a preservation method which provides continuous nutrient and oxygen supply to isolated organs by means of mechanical perfusion and membrane oxygenation. . Patent 201510085562.5 discloses a safety protection enhanced organ cryo-machine perfusion preservation device that performs organ preservation at low temperatures while achieving different perfusion modes by various control signals of the pump. Patent 201310723787.X discloses a transplant organ protection bag which is simple in structure, however, the device can only perform organ preservation at low temperatures, unable to supply oxygen and circulate blood. The above patents are only for the preservation of one organ and cannot store multiple or multiple organs at the same time.
通过血液灌注，外加上氧气、营养成分的供给，模拟一个健康的人体组织，不仅能够长时间保存人体器官，尤其对于肝脏等器官还具有修复作用。Through blood perfusion, plus the supply of oxygen and nutrients, simulating a healthy human tissue, not only can save human organs for a long time, especially for organs such as the liver.
发明内容 Summary of the invention
本发明的目的在于克服已有技术的不足，提供一种结构简单、可操作性好的多器官保存装置。The object of the present invention is to overcome the deficiencies of the prior art and to provide a multi-organ preservation device having a simple structure and good operability.
为了达到上述目的，本发明采用的技术方案是：In order to achieve the above object, the technical solution adopted by the present invention is:
多器官保存装置，包括推车，在所述的推车上安装有多器官保存设备，所述的多器官保存设备包括：A multi-organ preservation device comprising a cart, on which a multi-organ preservation device is installed, the multi-organ preservation device comprising:
一个水浴箱，在所述的水浴箱中放有一个多器官容器，在所述的多器官容器中设置有至少4个隔槽，每个隔槽用来放置不同的器官，全部所述的隔槽的底部通过管道互相联通，在任意一个所述隔槽底部开有一个隔槽出口，在所述的多器官容器上盖有一个容器罩，在所述的容器罩前后两侧分别通过两个对称设置的容器罩卡扣与多器官容器密封扣合，在所述的容器罩的外部罩有一个防菌罩，所述的防菌罩通过防菌罩卡扣与多容器罩紧密扣合，在所述的水浴箱中安装有温度传感器；a water bath in which a multi-organ container is placed, and at least four compartments are provided in the multi-organ container, each compartment for placing different organs, all of the compartments The bottom of the trough is connected to each other through a pipe, and a chute outlet is opened at the bottom of any one of the chutes, and a container cover is covered on the multi-organ container, and two sides are respectively passed on the front and rear sides of the container cover. The symmetrically disposed container cover buckle is sealingly fastened with the multi-organ container, and the outer cover of the container cover is covered with an anti-bacterial cover, and the anti-bacterial cover is closely engaged with the multi-container cover by the anti-bacterial cover buckle. a temperature sensor is installed in the water bath;
一个氧合装置，所述的氧合装置的进口通过管道与蠕动泵的出口相连通，一个氧气瓶的出口通过氧气管道与氧合装置的进口相连通，所述的氧合装置的出口与一个输送总管道相连，多个药物推送器的出口分别通过药物推送管道与所述的输送总管道相连通，所述的输送总管道的出口分为多个支路，在每一个支路上安装有一个进口流量控制阀，所述的每一个支路的出口端穿过水浴箱以及多器官容器并与多器官容器各个槽中的组织器官动脉血管一一连通，所述的隔槽出口与出口管道相连通，所述出口管道穿过水浴箱以及多器官容器并与一个依次连接有出口流量控制阀、过滤器以及蠕动泵的出口的出口总管相连通，所述过滤器的滤液出口低于多器官容器中的液面；An oxygenation device, the inlet of the oxygenation device is connected to the outlet of the peristaltic pump through a pipe, and the outlet of an oxygen cylinder is connected to the inlet of the oxygenation device through an oxygen conduit, the outlet of the oxygenation device and a The conveying main pipes are connected, and the outlets of the plurality of drug pushers are respectively connected to the conveying main pipe through the drug pushing pipe, the outlet of the conveying main pipe is divided into a plurality of branches, and one branch is installed on each branch road. An inlet flow control valve, the outlet end of each of the branches passes through a water bath and a multi-organ container and is in communication with a tissue and art vessel in each of the plurality of organ containers, the outlet of the compartment being connected to the outlet conduit The outlet conduit is passed through a water bath and a multi-organ container and is in communication with an outlet manifold that is connected to an outlet flow control valve, a filter, and an outlet of the peristaltic pump, the filtrate outlet of the filter being lower than the multi-organ container Liquid level in
至少3个具有刻度的器官分泌物容器，用来收集器官分泌物，每个器官容器分别通过穿过水浴箱的分泌物出口管道连接到所述多器官容器各隔槽中的器官相应的分泌物管道上；At least 3 scaled organ secretion containers for collecting organ secretions, each organ container being connected to a corresponding secretion of an organ in each compartment of the multi-organ container by a secretion outlet conduit through a water bath, respectively On the pipeline;
一个触摸显示屏，所述的触摸显示屏与控制器相连，通过所述的触摸显示屏输出控制信号给控制器并读取、显示控制器输出的信号，所述的控制器与蠕动泵、进口流量控制阀、出口流量控制阀以及温度传感器分别相连，所述的控制器读取温度传感器的信号并根据该温度 信号输出温度控制信号给水浴箱以对水浴箱中的水进行加热，所述的控制器读取进口流量控制阀和出口流量控制阀的信号，然后输出转动控制信号给蠕动泵。a touch display screen, the touch display screen is connected to the controller, and the control signal is outputted to the controller through the touch display screen, and the signal output by the controller is read and displayed, the controller and the peristaltic pump and the inlet a flow control valve, an outlet flow control valve, and a temperature sensor are respectively connected, and the controller reads the signal of the temperature sensor and according to the temperature The signal output temperature control signal is sent to the water bath to heat the water in the water bath, and the controller reads the signals of the inlet flow control valve and the outlet flow control valve, and then outputs a rotation control signal to the peristaltic pump.
与现有技术相比，本发明提供的多器官保存装置具有以下有益效果：Compared with the prior art, the multi-organ preservation device provided by the invention has the following beneficial effects:
1.本发明的多器官保存装置，结构简单，操作方便，能够长时间保存离体器官，甚至能够修复器官。1. The multi-organ preservation device of the invention has the advantages of simple structure, convenient operation, long-term preservation of the isolated organs, and even repair of the organs.
2.本发明的多器官保存装置可以同时保存和修复肝、肾、胰腺等器官，最多可以同时保存四个器官，可以最大化地进行器官利用。2. The multi-organ preservation device of the present invention can simultaneously store and repair organs such as liver, kidney, and pancreas, and can store up to four organs at the same time, thereby maximizing organ utilization.
3.本发明的多器官保存装置通过控制蠕动泵进行血液流量供应、流量控制阀进行流量和压力调节，能够在操作中能够保证合适的血液流量供应，通过氧气、药物或者营养物质供给，增加肝脏保存时间以及修复质量。3. The multi-organ preservation device of the present invention performs blood flow supply and flow control valve for flow rate and pressure regulation by controlling a peristaltic pump, and can ensure a proper blood flow supply during operation, and increase liver by supplying oxygen, drugs or nutrients. Save time and repair quality.
4.本发明的多器官保存装置，通过控制器智能控制水浴箱的温度，能够保证肝脏在所需温度下进行保存和修复，最大程度的防止非正常温度情况下造成肝脏的损害。4. The multi-organ preservation device of the present invention intelligently controls the temperature of the water bath by the controller, thereby ensuring that the liver is preserved and repaired at a desired temperature, thereby maximally preventing damage to the liver caused by abnormal temperature.
5.本发明的多器官保存装置，是一个推车的形式，方便医生或者相关工作人员进行移动，取用器官时灵活，还可以作为活体实验的培训系统。5. The multi-organ preservation device of the present invention is in the form of a cart, which is convenient for doctors or related staff to move, flexible when taking organs, and can also be used as a training system for living experiments.
附图说明DRAWINGS
图1为本发明的多器官保存装置原理示意图；Figure 1 is a schematic view showing the principle of a multi-organ preservation device of the present invention;
图2为本发明的前视角度的多器官保存装置的结构示意图；2 is a schematic structural view of a multi-organ preservation device of a front view angle of the present invention;
图3为本发明的后视角度的多器官保存装置的结构示意图。3 is a schematic view showing the structure of a multi-organ preservation device of a rear view angle of the present invention.
具体实施方式detailed description
下面结合具体实施例和附图对本发明进行详细描述。The invention is described in detail below with reference to specific embodiments and drawings.
如附图所示的本发明的多器官保存装置，包括推车，当有需要器官采集和运输的整个过程中，可以由工作人员推着进行器官的采集、运输以及作一些展示和简单的手术及实验。在所述的推车上安装有多器官保存设备，所述的多器官保存设备包括： The multi-organ preservation device of the present invention as shown in the accompanying drawings, including a cart, can be used by a worker to collect, transport, and perform some display and simple surgery throughout the process of organ collection and transportation. And experiment. A multi-organ preservation device is installed on the cart, and the multi-organ preservation device includes:
一个水浴箱300，水浴箱300可以应用商品化的产品也可以使用定制化的产品，大小根据实际需要决定，在所述的水浴箱中放有一个多器官容器108，在所述的多器官容器108中设置有至少4个隔槽，每个隔槽用来放置不同的器官。全部所述的隔槽的底部通过管道互相联通，在任意一个所述隔槽底部开有一个隔槽出口，在所述的多器官容器108上盖有一个容器罩109，在所述的容器罩109前后两侧分别通过两个对称设置的容器罩卡扣113与多器官容器108密封扣合，保证器官在运输过程中不会脱出多器官容器罩109。在所述的容器罩109的外部罩有一个防菌罩111，所述的防菌罩111通过防菌罩卡扣112与多容器罩108紧密扣合，防止细菌进入多器官容器108内部；在所述的水浴箱中安装有温度传感器；A water bath 300, the water bath 300 can be applied with a commercial product or a customized product, the size of which is determined according to actual needs, in which a multi-organ container 108 is placed in the multi-organ container There are at least 4 compartments in the 108, each compartment for placing different organs. The bottoms of all the compartments are connected to each other through a pipe, and a compartment outlet is opened at the bottom of any one of the compartments, and a container cover 109 is covered on the multi-organ container 108, and the container cover is covered. The front and rear sides of the 109 are respectively sealed and fastened with the multi-organ container 108 by two symmetrically disposed container cover buckles 113 to ensure that the organ does not come out of the multi-organ container cover 109 during transportation. An anti-bacterial cover 111 is disposed on the outside of the container cover 109, and the anti-bacterial cover 111 is closely engaged with the multi-container cover 108 by the anti-bacterial cover buckle 112 to prevent bacteria from entering the inside of the multi-organ container 108; a temperature sensor is installed in the water bath;
一个氧合装置103，所述的氧合装置103的进口通过管道与蠕动泵116的出口相连通，一个氧气瓶102的出口通过氧气管道与氧合装置103的进口相连通。所述的氧合装置116的出口与一个输送总管道相连，多个药物推送器101的出口分别通过药物推送管道与所述的输送总管道相连通，所述的输送总管道的出口分为多个支路，在每一个支路上安装有一个进口流量控制阀107-1，所述的每一个支路的出口端穿过水浴箱300以及多器官容器108并与多器官容器108各个槽中的组织器官动脉血管一一连通，所述的隔槽出口与出口管道相连通，所述出口管道穿过水浴箱300以及多器官容器108并与一个依次连接有出口流量控制阀107-2、过滤器120以及蠕动泵116的出口的出口总管相连通。所述的过滤器120安装应该稍低，以确保所述过滤器滤液出口低于多器官容器108中的液面。进口流量控制阀可以通过手动调节或者电动调节来控制血液流量大小。An oxygenation device 103, the inlet of the oxygenation device 103 is in communication with the outlet of the peristaltic pump 116 via a conduit, and the outlet of an oxygen cylinder 102 is in communication with the inlet of the oxygenation device 103 via an oxygen conduit. The outlet of the oxygenation device 116 is connected to a delivery main pipe, and the outlets of the plurality of drug pushers 101 are respectively connected to the conveying main pipe through a drug pushing pipe, and the outlet of the conveying main pipe is divided into many a branch road, on each of which a inlet flow control valve 107-1 is installed, the outlet end of each of the branches passing through the water bath 300 and the multi-organ container 108 and in the respective tanks of the multi-organ container 108 The tissue and arteries are connected one by one, and the outlet of the compartment is in communication with an outlet duct that passes through the water bath 300 and the multi-organ container 108 and is sequentially connected with an outlet flow control valve 107-2, a filter 120 and an outlet manifold of the outlet of the peristaltic pump 116 are in communication. The filter 120 installation should be slightly lower to ensure that the filter filtrate outlet is lower than the liquid level in the multi-organ container 108. The inlet flow control valve can be used to control blood flow by manual or electric adjustment.
至少3个具有刻度的器官分泌物容器115，用来收集尿液、胆汁、胰液等器官分泌物，每个器官容器分别通过穿过水浴箱300的分泌物出口管道连接到所述多器官容器108各隔槽中的器官相应的分泌物管道(如分泌胆汁的胆管等)上；At least three scaled organ secretion containers 115 for collecting organ secretions such as urine, bile, pancreatic juice, etc., each organ container being connected to the multi-organ container 108 by a secretion outlet conduit through a water bath 300, respectively. Corresponding secretion conduits (such as bile ducts secreting bile) in the organs in each compartment;
一个触摸显示屏105，所述的触摸显示屏105与控制器200相连，通过所述的触摸显示屏105输出控制信号给控制器并读取、显示控制器输出的信号，所述的控制器200与蠕动泵、进口流量控制阀107-1、出口流量控制阀107-2以及温度传感器分别相连，所述的控制器200 读取温度传感器的信号并根据该温度信号输出温度控制信号给水浴箱300以对水浴箱中的水进行加热，所述的控制器200读取进口流量控制阀107-1和出口流量控制阀107-2的信号，然后输出转动控制信号给蠕动泵。A touch display screen 105 is connected to the controller 200. The touch display screen 105 outputs a control signal to the controller and reads and displays a signal output by the controller. The controller 200 is provided. Connected to the peristaltic pump, the inlet flow control valve 107-1, the outlet flow control valve 107-2, and the temperature sensor, respectively, the controller 200 Reading the signal of the temperature sensor and outputting a temperature control signal to the water bath tank 300 according to the temperature signal to heat the water in the water bath, the controller 200 reads the inlet flow control valve 107-1 and the outlet flow control valve 107. The -2 signal is then output to the peristaltic pump.
作为本发明的一种优选的实施方式，所述的推车包括设置在推车底板上的上平台124，在所述的上平台124左侧固定有车把手110，在所述的推车底板上连接有四个车轮114。在所述的上平台124中间和右侧分别安装有中间隔板121和右侧隔板122，多个药物推送器101(药物推送器101的安装数量可根据实际需求而定)和氧气瓶102安装在所述的右侧隔板122右侧的上平台124上，所述的氧气瓶102通过氧气瓶固定带123固定在右侧连隔板122上，保证氧气瓶102固定不动。所述的蠕动泵116、氧合装置和过滤器120在所述的中间隔板121与右侧隔板122之间前后依次设置，所述的蠕动泵116固定在上平台124上并通过中间隔板121与右侧隔板122夹紧限制晃动。所述的氧合装置103悬吊固定连接在一个U形的氧合装置连接板104上，氧合装置连接板的U形两端分别固定在中间隔板121以及右侧隔板122上。所述的过滤器120通过过滤器支架118固定连接在中间隔板121上，所述的进口流量控制阀107-1固定安装在所述的中间隔板121的顶面上，所述的水浴箱300固定安装在中间隔板121左侧的上平台124上，所述的器官分泌物容器115安装在多器官容器108前侧的上平台124上。所述的触摸显示屏105通过触摸显示屏连接支架106固定在上平台124后侧。As a preferred embodiment of the present invention, the cart includes an upper platform 124 disposed on a bottom plate of the cart, and a handlebar 110 is fixed to the left side of the upper platform 124. Four wheels 114 are connected to the upper side. An intermediate partition 121 and a right partition 122 are respectively installed in the middle and the right side of the upper platform 124, and a plurality of drug pushers 101 (the number of the drug pushers 101 can be installed according to actual needs) and the oxygen cylinder 102 Installed on the upper platform 124 on the right side of the right side partition 122, the oxygen cylinder 102 is fixed to the right side partition plate 122 by the oxygen cylinder fixing belt 123 to ensure that the oxygen cylinder 102 is fixed. The peristaltic pump 116, the oxygenation device and the filter 120 are arranged one behind the other between the intermediate partition 121 and the right partition 122, and the peristaltic pump 116 is fixed on the upper platform 124 and passes through the middle interval. The plate 121 and the right side partition 122 are clamped to restrict the sway. The oxygenation device 103 is suspended and fixedly connected to a U-shaped oxygenation device connecting plate 104, and the U-shaped ends of the oxygenation device connecting plate are respectively fixed on the intermediate partition 121 and the right partition plate 122. The filter 120 is fixedly connected to the intermediate partition 121 through a filter holder 118, and the inlet flow control valve 107-1 is fixedly mounted on the top surface of the intermediate partition 121, the water bath box 300 is fixedly mounted on the upper platform 124 on the left side of the intermediate partition 121, and the organ secretion container 115 is mounted on the upper platform 124 on the front side of the multi-organ container 108. The touch display screen 105 is fixed to the rear side of the upper platform 124 by the touch screen display connection bracket 106.
所述的进口流量控制阀和出口流量控制阀采用机械式手动阀门或者所述的进口流量控制阀和出口流量控制阀采用电动控制阀门。The inlet flow control valve and the outlet flow control valve adopt a mechanical manual valve or the inlet flow control valve and the outlet flow control valve adopt an electric control valve.
图4是多器官保存装置的原理示意图，各个器官存放在多器官容器108中，血液经蠕动泵116提供动力之后进入氧合装置103，氧气瓶102中的氧进入氧合装置116与血液氧合。氧合后血液流入各器官，药物推送器101推送肝脏的药物或者营养物质与血液混合后进入各脏体体内。进入各个器官的血液流量和大小通过各自的进口流量控制阀107-1来控制，血液经各器官后回流到过滤器120，回流的流量和压力通过出口流量控制阀107-2调节，血液里的泡浮以及杂质等经过滤器120过滤后再流回蠕动泵116。在使用过程中,可以根据使用要求 在流入各个器官的血液的管道上夹持压力和流量传感器测量压力、流量并传输给控制器200并且水浴箱300中的温度信号等也通过传感器连接到控制器200中，控制器200根据需要调节水浴箱300中的水温，同时根据各参数及医生的指导下调节蠕动泵116的转速。医生可以通过触摸显示屏105进行多器官保存装置的设置以及可以看到各个部件运行状况信息。4 is a schematic diagram of the principle of a multi-organ storage device. Each organ is stored in a multi-organ container 108. After the blood is powered by the peristaltic pump 116, the blood enters the oxygenation device 103, and the oxygen in the oxygen cylinder 102 enters the oxygenation device 116 to oxygenate the blood. . After the oxygenation, the blood flows into the organs, and the drug or nutrient which the drug pusher 101 pushes the liver mixes with the blood and enters each body. The blood flow and size entering each organ are controlled by respective inlet flow control valves 107-1, and the blood is returned to the filter 120 through the various organs, and the flow and pressure of the reflux are regulated by the outlet flow control valve 107-2. The bubbles, impurities, and the like are filtered by the filter 120 and then returned to the peristaltic pump 116. In use, according to the use requirements The pressure and flow sensors are clamped on the tubes of the blood flowing into the respective organs to measure the pressure, flow rate, and transmitted to the controller 200, and the temperature signals and the like in the water bath tank 300 are also connected to the controller 200 through sensors, and the controller 200 adjusts as needed. The water temperature in the water bath 300 is adjusted while the rotational speed of the peristaltic pump 116 is adjusted according to various parameters and instructions from a doctor. The doctor can perform the setting of the multi-organ preservation device by touching the display screen 105 and can see the operational status information of each component.
以上示意性的对本发明及其实施方式进行了描述，该描述没有限制性，附图中所示的只是本发明的几种实施方式，实际的结构也并不局限于此。如果本领域的技术人员受其启示，在不脱离本发明创造宗旨的情况下，采用其它形式的结构、传动以及安装及连接方式不经创造性的设计与该技术方案相似的结构方式及实施例，均应属于本发明的保护范围。 The above description of the invention and its embodiments are described above, and the description is not limited thereto, and only a few embodiments of the invention are shown in the drawings, and the actual structure is not limited thereto. Other forms of construction, transmission, and installation and connection are inconspicuously designed in a manner similar to that of the technical solution, without departing from the spirit of the invention. All should fall within the scope of protection of the present invention.

Claims (4)

  1. 多器官保存装置，其特征在于：包括推车，在所述的推车上安装有多器官保存设备，所述的多器官保存设备包括：A multi-organ preservation device, comprising: a cart, on which a multi-organ preservation device is installed, the multi-organ preservation device comprising:
    一个水浴箱，在所述的水浴箱中放有一个多器官容器，在所述的多器官容器中设置有至少4个隔槽，每个隔槽用来放置不同的器官，全部所述的隔槽的底部通过管道互相联通，在任意一个所述隔槽底部开有一个隔槽出口，在所述的多器官容器上盖有一个容器罩，在所述的容器罩前后两侧分别通过两个对称设置的容器罩卡扣与多器官容器密封扣合，在所述的容器罩的外部罩有一个防菌罩，所述的防菌罩通过防菌罩卡扣与多容器罩紧密扣合，在所述的水浴箱中安装有温度传感器；a water bath in which a multi-organ container is placed, and at least four compartments are provided in the multi-organ container, each compartment for placing different organs, all of the compartments The bottom of the trough is connected to each other through a pipe, and a chute outlet is opened at the bottom of any one of the chutes, and a container cover is covered on the multi-organ container, and two sides are respectively passed on the front and rear sides of the container cover. The symmetrically disposed container cover buckle is sealingly fastened with the multi-organ container, and the outer cover of the container cover is covered with an anti-bacterial cover, and the anti-bacterial cover is closely engaged with the multi-container cover by the anti-bacterial cover buckle. a temperature sensor is installed in the water bath;
    一个氧合装置，所述的氧合装置的进口通过管道与蠕动泵的出口相连通，一个氧气瓶的出口通过氧气管道与氧合装置的进口相连通，所述的氧合装置的出口与一个输送总管道相连，多个药物推送器的出口分别通过药物推送管道与所述的输送总管道相连通，所述的输送总管道的出口分为多个支路，在每一个支路上安装有一个进口流量控制阀，所述的每一个支路的出口端穿过水浴箱以及多器官容器并与多器官容器各个槽中的组织器官动脉血管一一连通，所述的隔槽出口与出口管道相连通，所述出口管道穿过水浴箱以及多器官容器并与一个依次连接有出口流量控制阀、过滤器以及蠕动泵的出口的出口总管相连通，所述过滤器的滤液出口低于多器官容器中的液面；An oxygenation device, the inlet of the oxygenation device is connected to the outlet of the peristaltic pump through a pipe, and the outlet of an oxygen cylinder is connected to the inlet of the oxygenation device through an oxygen conduit, the outlet of the oxygenation device and a The conveying main pipes are connected, and the outlets of the plurality of drug pushers are respectively connected to the conveying main pipe through the drug pushing pipe, the outlet of the conveying main pipe is divided into a plurality of branches, and one branch is installed on each branch road. An inlet flow control valve, the outlet end of each of the branches passes through a water bath and a multi-organ container and is in communication with a tissue and art vessel in each of the plurality of organ containers, the outlet of the compartment being connected to the outlet conduit The outlet conduit is passed through a water bath and a multi-organ container and is in communication with an outlet manifold that is connected to an outlet flow control valve, a filter, and an outlet of the peristaltic pump, the filtrate outlet of the filter being lower than the multi-organ container Liquid level in
    至少3个具有刻度的器官分泌物容器，用来收集器官分泌物，每个器官容器分别通过穿过水浴箱的分泌物出口管道连接到所述多器官容器各隔槽中的器官相应的分泌物管道上；At least 3 scaled organ secretion containers for collecting organ secretions, each organ container being connected to a corresponding secretion of an organ in each compartment of the multi-organ container by a secretion outlet conduit through a water bath, respectively On the pipeline;
    一个触摸显示屏，所述的触摸显示屏与控制器相连，通过所述的触摸显示屏输出控制信号给控制器并读取、显示控制器输出的信号，所述的控制器与蠕动泵、进口流量控制阀、出口流量控制阀以及温度传感器分别相连，所述的控制器读取温度传感器的信号并根据该温度信号输出温度控制信号给水浴箱以对水浴箱中的水进行加热，所述的控制器读取进口流量控制阀和出口流量控制阀的信号，然后输出转动控制信号给蠕动泵。 a touch display screen, the touch display screen is connected to the controller, and the control signal is outputted to the controller through the touch display screen, and the signal output by the controller is read and displayed, the controller and the peristaltic pump and the inlet The flow control valve, the outlet flow control valve and the temperature sensor are respectively connected, the controller reads the signal of the temperature sensor and outputs a temperature control signal to the water bath according to the temperature signal to heat the water in the water bath, The controller reads the signals of the inlet flow control valve and the outlet flow control valve, and then outputs a rotation control signal to the peristaltic pump.
  2. 根据权利要求1所述的多器官保存装置，其特征在于：所述的推车包括设置在推车底板上的上平台，在所述的上平台左侧固定有车把手，在所述的推车底板上连接有四个车轮，在所述的上平台中间和右侧分别安装有中间隔板和右侧隔板，多个药物推送器和氧气瓶安装在所述的右侧隔板右侧的上平台上，所述的氧气瓶通过氧气瓶固定带固定在右侧连隔板上，所述的蠕动泵、氧合装置和过滤器在所述的中间隔板与右侧隔板之间前后依次设置，所述的蠕动泵固定在上平台上并通过中间隔板与右侧隔板夹紧限制晃动，所述的氧合装置悬吊固定连接在一个U形的氧合装置连接板上，氧合装置连接板的U形两端分别固定在中间隔板以及右侧隔板上，所述的过滤器通过过滤器支架固定连接在中间隔板上，所述的进口流量控制阀固定安装在所述的中间隔板的顶面上，所述的水浴箱固定安装在中间隔板左侧的上平台上，所述的器官分泌物容器安装在多器官容器前侧的上平台上，所述的触摸显示屏通过触摸显示屏连接支架固定在上平台后侧。The multiple organ storage device according to claim 1, wherein said cart comprises an upper platform disposed on a floor of the cart, and a handlebar is fixed on a left side of said upper platform, said push Four wheels are connected to the floor of the vehicle, and an intermediate partition and a right side partition are respectively installed in the middle and the right side of the upper platform, and a plurality of drug pushers and oxygen cylinders are installed on the right side of the right side partition plate On the upper platform, the oxygen cylinder is fixed on the right side partition by an oxygen cylinder fixing belt, and the peristaltic pump, the oxygenation device and the filter are between the intermediate partition and the right partition Arranged in sequence, the peristaltic pump is fixed on the upper platform and is restrained from shaking by the intermediate partition plate and the right side plate. The oxygenation device is suspended and fixedly connected to a U-shaped oxygenation device connecting plate. The U-shaped ends of the oxygenation device connecting plate are respectively fixed on the intermediate partition plate and the right side partition plate, and the filter is fixedly connected to the middle partition plate through the filter bracket, and the inlet flow control valve is fixedly installed. On the top surface of the intermediate partition, The water bath is fixedly mounted on the upper platform on the left side of the intermediate partition, the organ secretion container is mounted on the upper platform on the front side of the multi-organ container, and the touch display screen is fixed on the upper by the touch screen display bracket The back side of the platform.
  3. 根据权利要求1或者2所述的多器官保存装置，其特征在于：所述的进口流量控制阀和出口流量控制阀采用机械式手动阀门。A multiple organ storage device according to claim 1 or 2, wherein said inlet flow control valve and outlet flow control valve employ mechanical manual valves.
  4. 根据权利要求1或者2所述的多器官保存装置，其特征在于：所述的进口流量控制阀和出口流量控制阀采用电动控制阀门。 A multiple organ storage device according to claim 1 or 2, wherein said inlet flow control valve and said outlet flow control valve employ an electrically controlled valve.
PCT/CN2017/072740 2016-10-28 2017-01-26 Multi-organ preservation apparatus WO2018076567A1 (en)

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