CN112006016A - Normal temperature oxygenation perfusion apparatus - Google Patents
Normal temperature oxygenation perfusion apparatus Download PDFInfo
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- CN112006016A CN112006016A CN201910470826.7A CN201910470826A CN112006016A CN 112006016 A CN112006016 A CN 112006016A CN 201910470826 A CN201910470826 A CN 201910470826A CN 112006016 A CN112006016 A CN 112006016A
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- 238000006213 oxygenation reaction Methods 0.000 title claims abstract description 67
- 230000010412 perfusion Effects 0.000 title claims abstract description 29
- 239000008280 blood Substances 0.000 claims abstract description 163
- 210000004369 blood Anatomy 0.000 claims abstract description 163
- 230000004087 circulation Effects 0.000 claims abstract description 68
- 210000000056 organ Anatomy 0.000 claims abstract description 66
- 210000001367 artery Anatomy 0.000 claims abstract description 32
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 21
- 239000001301 oxygen Substances 0.000 claims abstract description 21
- 210000003462 vein Anatomy 0.000 claims abstract description 21
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 9
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 9
- 238000001802 infusion Methods 0.000 claims description 74
- 239000012528 membrane Substances 0.000 claims description 40
- 239000007788 liquid Substances 0.000 claims description 32
- 238000001990 intravenous administration Methods 0.000 claims description 25
- 230000001105 regulatory effect Effects 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000008236 heating water Substances 0.000 claims description 13
- 230000036770 blood supply Effects 0.000 claims description 6
- 238000005086 pumping Methods 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 5
- 230000008320 venous blood flow Effects 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 2
- 230000008321 arterial blood flow Effects 0.000 claims 1
- 230000004083 survival effect Effects 0.000 abstract description 8
- 230000017531 blood circulation Effects 0.000 abstract description 4
- 238000012544 monitoring process Methods 0.000 description 9
- 230000037452 priming Effects 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 5
- 238000002054 transplantation Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
Abstract
The invention provides normal-temperature oxygenation perfusion equipment which comprises an open type blood storage container, a first artery circulation pipeline, a constant-temperature oxygenation device, a second artery circulation pipeline and a vein circulation pipeline, wherein the first artery circulation pipeline is used for conveying blood in the open type blood storage container to the constant-temperature oxygenation device so as to exchange oxygen and carbon dioxide for the blood and heat the blood to a preset temperature; a second arterial circulation line for communicating with an artery of the donor organ placed in the open blood storage container to supply blood to the artery of the donor organ; the venous circulation line is for communicating with a vein of a donor organ to supply blood to the vein of the donor organ. When the donor organ is picked up and transported for a long distance between clinical operations, the real living environment of the human organ can be simulated to carry out blood circulation perfusion on the donor organ, so that the organ survival is ensured. Solves the problem of low survival rate of donor organs after the donor organs are separated from the human body for a long time from the picking to the clinical operation in the prior art.
Description
Technical Field
The invention relates to the field of blood regulation and control equipment, in particular to normal-temperature oxygenation perfusion equipment.
Background
At present, in the medical field, organ transplantation is often needed for seriously ill patients to cure certain end-stage diseases which are harmful to body health, but donor organs are in shortage, and long-distance transportation is possibly involved when proper donor organs are met, so that the organs are in a state of being separated from a human body for a long time from harvesting to clinical operation, the survival rate of the organs is greatly reduced, and the successful operation is influenced.
Disclosure of Invention
The invention mainly aims to provide a normal-temperature oxygenation perfusion device, which solves the problem that in the prior art, the survival rate of donor organs is low after the donor organs are separated from a human body for a long time from the picking to the clinical operation.
In order to achieve the above object, the present invention provides a normothermic oxygenation perfusion apparatus, comprising: an open blood storage container for storing blood; the inlet end of the first arterial circulation pipeline is communicated with the outlet end of the open blood storage container; the outlet end of the first arterial circulation pipeline is communicated with the blood inlet end of the constant-temperature oxygenation device so as to convey the blood in the open blood storage container to the constant-temperature oxygenation device, so that oxygen and carbon dioxide exchange is carried out on the blood, and the blood is heated to a preset temperature; the inlet end of the second arterial circulation pipeline is communicated with the first outlet end of the constant-temperature oxygenation device, the outlet end of the second arterial circulation pipeline extends into the open blood storage container, and the outlet end of the second arterial circulation pipeline is communicated with the artery of the donor organ placed in the open blood storage container to supply blood to the artery of the donor organ; and the inlet end of the venous circulation pipeline is communicated with the second outlet end of the constant-temperature oxygenation device, the outlet end of the venous circulation pipeline extends into the open blood storage container, and the outlet end of the venous circulation pipeline is used for being communicated with the veins of the donor organ to supply blood to the veins of the donor organ.
Further, the first arterial circulation line comprises: the inlet end of the first artery infusion tube is communicated with the outlet end of the open blood storage container, and the outlet end of the first artery infusion tube is communicated with the blood inlet end of the constant-temperature oxygenation device; the arterial infusion pump is arranged on the first arterial infusion tube and used for generating pumping force so as to convey blood in the open blood storage container to the constant-temperature oxygenation device through the first arterial infusion tube.
Further, the constant temperature oxygenation device comprises: the outlet end of the first arterial circulation pipeline is communicated with the blood inlet end of the membrane oxygenator so as to convey the blood in the open blood storage container to the membrane oxygenator; the membrane oxygenator is used for infusing oxygen into blood and discharging carbon dioxide in the blood.
Further, be provided with heat exchange pipe in the membrane oxygenator, constant temperature oxygenation device still includes: the constant temperature heating water tank is provided with a hot water outlet and a water return port, and the hot water outlet and the water return port are respectively and correspondingly communicated with two ports of a heat exchange tube in the membrane oxygenator so that hot water in the constant temperature heating water tank circularly flows through the heat exchange tube to heat blood flowing through the membrane oxygenator to a preset temperature.
Further, the constant temperature oxygenation device also comprises: and the oxygen cylinder is communicated with the oxygen inlet end of the membrane oxygenator so as to supply oxygen to the membrane oxygenator.
Further, the second arterial circulation circuit comprises: and the inlet end of the second artery infusion tube is communicated with the first outlet end of the constant-temperature oxygenation device, and the outlet end of the second artery infusion tube extends into the open blood storage container and is communicated with the artery of the donor organ so as to supply blood to the artery of the donor organ.
Further, the second arterial circulation line further comprises: the first flowmeter is arranged on the second arterial infusion tube to monitor the arterial blood supply flow; the first flow regulating valve is arranged on the second arterial infusion tube to regulate the arterial blood supply flow; and the pressure gauge is arranged on the second arterial infusion tube to monitor the arterial blood supply pressure.
Further, the venous circulation line comprises: the inlet end of the first venous transfusion tube is communicated with the second outlet end of the constant-temperature oxygenation device; the outlet end of the first venous transfusion tube is communicated with the inlet end of the closed blood storage container so as to convey the blood from the constant-temperature oxygenation device to the closed blood storage container for temporary storage; the inlet end of the second venous transfusion tube is communicated with the outlet end of the closed blood storage container, and the outlet end of the second venous transfusion tube extends into the open blood storage container to be communicated with the veins of the donor organs; and the intravenous infusion pump is arranged on the second intravenous infusion tube and is used for generating pumping force to supply blood to the vein of the donor organ.
Further, a liquid level sensor is arranged inside the closed blood storage container and used for monitoring the liquid level in the closed blood storage container; wherein the intravenous infusion pump is adapted to be activated to supply blood to a vein of the donor organ when a liquid level within the closed blood storage container is above a preset minimum liquid level.
Further, the venous circulation line further comprises: a second flow meter disposed on a second venous infusion tube to monitor venous blood flow; and the second flow regulating valve is arranged on the second venous transfusion tube to regulate the venous blood supply flow.
The normal-temperature oxygenation perfusion equipment applying the technical scheme of the invention comprises an open blood storage container, a first arterial circulation pipeline, a constant-temperature oxygenation device, a second arterial circulation pipeline and a venous circulation pipeline, wherein the open blood storage container is used for storing blood; the inlet end of the first arterial circulation pipeline is communicated with the outlet end of the open blood storage container; the outlet end of the first arterial circulation pipeline is communicated with the blood inlet end of the constant-temperature oxygenation device so as to convey the blood in the open blood storage container to the constant-temperature oxygenation device, so that oxygen and carbon dioxide exchange is carried out on the blood, and the blood is heated to a preset temperature; the inlet end of the second arterial circulation pipeline is communicated with the first outlet end of the constant-temperature oxygenation device, the outlet end of the second arterial circulation pipeline extends into the open blood storage container, and the outlet end of the second arterial circulation pipeline is used for being communicated with an artery of a donor organ placed in the open blood storage container so as to supply blood to the artery of the donor organ; the inlet end of the venous circulation pipeline is communicated with the second outlet end of the constant-temperature oxygenation device, the outlet end of the venous circulation pipeline extends into the open blood storage container, and the outlet end of the venous circulation pipeline is used for being communicated with veins of the donor organ to supply blood to the veins of the donor organ. Therefore, when the trachea is transplanted, the blood circulation perfusion can be carried out on the donor organ when the long-distance transportation is carried out between the taking of the donor organ and the clinical operation, the real living environment of the human organ is simulated, the survival of the donor organ is ensured, and more time is won for the transplantation operation. Solves the problem of low survival rate of donor organs after the donor organs are separated from the human body for a long time from the picking to the clinical operation in the prior art.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the invention and, together with the description, serve to explain the invention and not to limit the invention. In the drawings:
FIG. 1 is a block diagram of an alternative embodiment of an ambient temperature oxygenation perfusion apparatus according to the present invention;
FIG. 2 is a block diagram of another alternative cryooxygenation perfusion apparatus according to an embodiment of the present invention;
FIG. 3 is a schematic diagram illustrating a first view of an alternative normothermic oxygenation perfusion apparatus according to an embodiment of the present invention;
FIG. 4 is a schematic diagram illustrating a second view of an alternative normothermic oxygenation perfusion apparatus according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of a third view of an alternative normothermic oxygenation perfusion apparatus according to an embodiment of the present invention; and
fig. 6 is a schematic structural diagram of a fourth view angle of an alternative normothermic oxygenation perfusion apparatus according to an embodiment of the invention.
Wherein the figures include the following reference numerals:
10. an open blood storage container; 20. a first arterial circulation line; 21. a first arterial infusion tube; 22. an arterial infusion pump; 30. a constant temperature oxygenation device; 31. a membrane oxygenator; 32. heating the water tank at a constant temperature; 33. an oxygen cylinder; 40. a second arterial circulation line; 41. a second arterial infusion tube; 42. a first flow meter; 43. a first flow regulating valve; 44. a pressure gauge; 50. a venous circulation line; 51. a first intravenous line; 52. a closed blood storage container; 53. a second venous infusion tube; 54. an intravenous infusion pump; 55. a liquid level sensor; 56. a second flow meter; 57. a second flow regulating valve; 60. a donor organ; 70. a controller; 80. a driver; 90. a switching power supply; 100. a power conversion module; 110. a display screen; 120. and (5) moving the trolley.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to the embodiments with reference to the attached drawings.
The normothermic oxygenation perfusion device according to the embodiment of the invention, as shown in fig. 1, comprises an open blood storage container 10, a first arterial circulation pipeline 20, a thermostatic oxygenation device 30, a second arterial circulation pipeline 40 and a venous circulation pipeline 50, wherein the open blood storage container 10 is used for storing blood; the inlet end of the first arterial circulation line 20 is communicated with the outlet end of the open blood storage container 10; the outlet end of the first arterial circulation line 20 is communicated with the blood inlet end of the constant temperature oxygenation device 30 to convey the blood in the open blood storage container 10 to the constant temperature oxygenation device 30, so as to exchange oxygen and carbon dioxide for the blood and heat the blood to a preset temperature; the inlet end of the second arterial circulation line 40 is communicated with the first outlet end of the thermostatic oxygenation device 30, the outlet end of the second arterial circulation line 40 extends into the open blood storage container 10, and the outlet end of the second arterial circulation line 40 is used for being communicated with the artery of the donor organ 60 placed in the open blood storage container 10 so as to supply blood to the artery of the donor organ 60; the inlet end of the venous circulation line 50 communicates with a second outlet end of the thermostatic oxygenation device 30, the outlet end of the venous circulation line 50 extends into the open blood reservoir 10, and the outlet end of the venous circulation line 50 is for communication with a vein of the donor organ 60 for supplying blood to the vein of the donor organ 60. Therefore, when the trachea is transplanted, blood circulation perfusion can be carried out on the donor organ 60 when the long-distance transportation is carried out between the taking of the donor organ 60 and the clinical operation, the real living environment of the human organ is simulated, the survival of the donor organ 60 is ensured, and more time is won for the transplantation operation. Solves the problem of low survival rate of the donor organ 60 after being separated from the human body for a long time from the extraction to the clinical operation in the prior art.
In specific implementation, as shown in fig. 2 to 4, the open blood storage container 10 is a blood storage basin, the blood storage basin is mounted on the upper portion of the mobile cart 120, the first arterial circulation line 20 includes a first arterial infusion line 21 and an arterial infusion pump 22, an inlet end of the first arterial infusion line 21 is communicated with an outlet end of the open blood storage container 10, as shown in fig. 5, the thermostatic oxygenation device 30 includes a membrane oxygenator 31, a thermostatic heating water tank 32 and an oxygen bottle 33, an outlet end of the first arterial circulation line 20 is communicated with a blood inlet end of the membrane oxygenator 31, the arterial infusion pump 22 is disposed on the first arterial infusion line 21, the arterial infusion pump 22 is configured to generate a pumping force to convey blood in the open blood storage container 10 to the membrane oxygenator 31 through the first arterial infusion line 21, the oxygen bottle 33 is communicated with an oxygen inlet end of the membrane oxygenator 31 to supply oxygen to the membrane oxygenator 31, the membrane oxygenator 31 is used to incorporate oxygen into blood and to remove carbon dioxide from blood.
Further, a heat exchange pipe is arranged in the membrane oxygenator 31, a heating device, a temperature monitoring sensor and a micro water circulation device are arranged in the constant-temperature heating water tank 32, the heating device heats water in the constant-temperature heating water tank 32, the temperature monitoring sensor is used for monitoring the water temperature in the water tank, and the heating device stops running after the water temperature reaches a set temperature. The constant temperature heating water tank 32 is provided with a hot water outlet and a water return port which are respectively communicated with two ports of a heat exchange tube in the membrane oxygenator 31, and the hot water in the constant temperature heating water tank 32 circulates through the heat exchange tube under the action of the miniature water circulation device so as to heat the blood flowing through the membrane oxygenator 31.
The oxygenation chamber of the membrane oxygenator 31 exchanges oxygen and carbon dioxide with the blood circulating from the open blood storage container 10 to become arterial blood, and the circulating hot water in the constant temperature heating water tank 32 heats the blood in the membrane oxygenator 31 to adjust the temperature of the blood. The temperature of the circulating blood is brought closer to the physiological temperature of the human body by the oxygenation chamber in the membrane oxygenator 31, and the supply of oxygenated blood to the organs is maintained, thereby temporarily replacing the function of the lungs.
The second arterial circulation line 40 comprises a second arterial infusion tube 41, a first flow meter 42, a first flow regulating valve 43 and a pressure meter 44, wherein the inlet end of the second arterial infusion tube 41 is communicated with the first outlet end of the membrane oxygenator 31, and the outlet end of the second arterial infusion tube 41 extends into the open blood storage container 10 to be communicated with the artery of the donor organ 60 so as to supply blood to the artery of the donor organ 60; a first flow meter 42 is disposed on the second arterial infusion tube 41 to monitor arterial supply flow; a first flow regulating valve 43 is arranged on the second arterial infusion tube 41 to regulate the arterial blood supply flow; a pressure gauge 44 is provided on the second arterial infusion tube 41 to monitor arterial supply pressure.
The venous circulation pipeline 50 comprises a first venous transfusion pipe 51, a closed blood storage container 52, a second venous transfusion pipe 53, a venous transfusion pump 54, a liquid level sensor 55, a second flow meter 56 and a second flow regulating valve 57, wherein the inlet end of the first venous transfusion pipe 51 is communicated with the second outlet end of the membrane oxygenator 31; the closed blood storage container 52 is a blood storage tank, and the outlet end of the first venous transfusion tube 51 is communicated with the inlet end of the closed blood storage container 52 so as to convey the blood from the membrane oxygenator 31 to the closed blood storage container 52 for temporary storage; the inlet end of the second intravenous line 53 communicates with the outlet end of the closed blood reservoir 52, and the outlet end of the second intravenous line 53 extends into the open blood reservoir 10 to communicate with the veins of the donor organ 60; an intravenous infusion pump 54 is disposed on the second intravenous infusion tube 53, the intravenous infusion pump 54 for generating a pumping force to supply blood to a vein of the donor organ 60; a second flow meter 56 is disposed on the second venous infusion line 53 to monitor venous blood flow; a second flow regulating valve 57 is provided on the second intravenous tubing 53 to regulate the venous supply flow.
The first flow meter 42 and the second flow meter 56 are both non-contact blood flow meters.
Further, a liquid level sensor 55 is arranged inside the closed blood storage container 52, and the liquid level sensor 55 is used for monitoring the liquid level in the closed blood storage container 52; the intravenous infusion pump 54 is adapted to be activated to supply blood to a vein of the donor organ 60 when the liquid level within the closed blood reservoir 52 is above a preset minimum level. By providing the level sensor 55 and ensuring that the liquid level in the closed blood storage container 52 is above a predetermined minimum level, it is possible to avoid air bubbles entering the donor organ 60 after the blood in the closed blood storage container 52 has been drained.
In practical application, as shown in fig. 6, the normal temperature oxygenation perfusion apparatus of the embodiment further includes a controller 70, a driver 80, a switching power supply 90, a power conversion module 100 and a display screen 110, wherein the controller 70, the driver 80, the switching power supply 90 and the power conversion module 100 are disposed at a lower side of the mobile cart 120, the display screen 110 is disposed at an upper portion of the mobile cart 120, the controller 70 is connected with the first flow meter 42, the pressure gauge 44, the liquid level sensor 55 and the second flow meter 56 to obtain corresponding monitoring signals, the driver 80 is connected with the arterial infusion pump 22, the membrane oxygenator 31, the constant temperature heating water tank 32, the first flow regulating valve 43, the venous infusion pump 54 and the second flow regulating valve 57, and the controller 70 is connected with the driver 80 to control the arterial infusion pump 22, the membrane oxygenator 31 and the constant temperature heating water tank 32 through the driver 80 according to the corresponding monitoring signals, The first flow rate regulating valve 43, the intravenous infusion pump 54, and the second flow rate regulating valve 57 are started, stopped, or perform corresponding control actions. Meanwhile, the controller 70 is connected to the display screen 110 to send various monitoring signals to the display screen 110 for displaying. The switch power supply 90 is connected with an external power supply and the power conversion module 100, the power conversion module 100 is connected with the driver 80, and the power conversion module 100 is used for supplying power to the arterial infusion pump 22, the membrane oxygenator 31, the constant temperature heating water tank 32, the first flow regulating valve 43, the venous infusion pump 54, the second flow regulating valve 57 and the like through the driver 80 after the external power supply is correspondingly converted so as to drive the units to operate.
During specific work, the controller 70 is used for setting parameters of the constant temperature and the arterial pressure of the membrane oxygenator 31, parameters of the venous and arterial flow ranges and parameters of the liquid level of the closed blood storage container 52, and the set parameters can be displayed on the display screen 110. The priming liquid is added into the open type blood storage container 10, the system is started for preheating, after the temperature of the priming liquid is heated to a set temperature, the controller 70 controls the arterial infusion pump 22 to start through the driver 80, the priming liquid is conveyed to the membrane oxygenator 31 through the first arterial infusion tube 21, after oxygenation and heating, one part of the priming liquid is conveyed to the closed type blood storage container 52 through the first venous infusion tube 51, the other part of the priming liquid is conveyed back to the open type blood storage container 10 through the second arterial infusion tube 41, the first flow meter 42 and the pressure gauge 44 which are arranged on the second arterial infusion tube 41 can monitor arterial flow and pressure and feed back to the controller 70, and the controller 70 controls the first flow regulating valve 43 to regulate the arterial flow according to the arterial flow and pressure signals; when the liquid level of the closed blood storage container 52 is higher than the lowest liquid level, the controller 70 controls the intravenous infusion pump 54 to start through the driver 80, the priming liquid in the closed blood storage container 52 is delivered back to the open blood storage container 10 through the second intravenous infusion tube 53, the second flow meter 56 arranged on the second intravenous infusion tube 53 monitors the venous flow in real time and feeds back the venous flow to the controller 70, and the controller 70 controls the second flow regulating valve 57 to regulate the venous flow according to the venous flow signal. The priming liquid is added to check the sealing condition of each pipeline and the operating condition of each sensor, so that the sealing of each infusion pipeline is confirmed to be good, and after each sensor works normally, the priming liquid is discharged through the second arterial infusion tube 41.
After the priming liquid is discharged, the blood is injected into the open blood storage container 10, part of the blood enters the closed blood storage container 52 through the membrane oxygenator 31 and the first venous transfusion tube 51, when the liquid level in the closed blood storage container 52 is higher than the lowest liquid level, the first venous transfusion tube 51 is closed by using a Robert clamp, and the system stops working. Then the donor organ 60 is placed in the open blood storage container 10, the outlet end of the second arterial infusion tube 41 and the outlet end of the second venous infusion tube 53 are respectively connected to the artery and the vein of the donor organ 60, the system is started to work, and after the blood in the open blood storage container 10 is oxygenated and heated by the membrane oxygenator 31, a part of the blood is delivered to the donor organ 60 through the second arterial infusion tube 41, and a part of the blood is delivered to the donor organ 60 through the second venous infusion tube 53. At this time, the operation states of the arterial infusion pump 22, the first flow regulating valve 43, the venous infusion pump 54 and the second flow regulating valve 57 are regulated according to the monitoring data of the first flow meter 42, the pressure meter 44, the liquid level sensor 55 and the second flow meter 56, so that the reliability and the stability of the normal-temperature oxygenation perfusion device are ensured.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A normothermic oxygenation perfusion apparatus, comprising:
an open blood storage container (10), the open blood storage container (10) for storing blood;
a first arterial circulation line (20), an inlet end of the first arterial circulation line (20) being in communication with an outlet end of the open blood reservoir (10);
a constant temperature oxygenation device (30), wherein the outlet end of the first arterial circulation pipeline (20) is communicated with the blood inlet end of the constant temperature oxygenation device (30) so as to convey the blood in the open blood storage container (10) to the constant temperature oxygenation device (30) so as to exchange oxygen and carbon dioxide for the blood and heat the blood to a preset temperature;
a second arterial circulation line (40), an inlet end of the second arterial circulation line (40) being in communication with a first outlet end of the thermostatic oxygenation device (30), an outlet end of the second arterial circulation line (40) extending into the open blood reservoir (10), an outlet end of the second arterial circulation line (40) being for communication with an artery of a donor organ (60) placed in the open blood reservoir (10) for supplying blood to the artery of the donor organ (60);
a venous circulation line (50), an inlet end of the venous circulation line (50) communicating with a second outlet end of the thermostatic oxygenation device (30), an outlet end of the venous circulation line (50) extending into the open blood reservoir (10), an outlet end of the venous circulation line (50) for communicating with a vein of the donor organ (60) for supplying blood to a vein of the donor organ (60).
2. The normothermic oxygenation perfusion apparatus of claim 1, wherein the first arterial circulation line (20) comprises:
the inlet end of the first artery infusion tube (21) is communicated with the outlet end of the open blood storage container (10), and the outlet end of the first artery infusion tube (21) is communicated with the blood inlet end of the constant-temperature oxygenation device (30);
the artery infusion pump (22) is arranged on the first artery infusion tube (21), and the artery infusion pump (22) is used for generating pumping force to convey blood in the open blood storage container (10) to the constant-temperature oxygenation device (30) through the first artery infusion tube (21).
3. The normothermic oxygenation perfusion apparatus of claim 1, wherein the thermostatical oxygenation device (30) comprises:
a membrane oxygenator (31), wherein the outlet end of the first arterial circulation pipeline (20) is communicated with the blood inlet end of the membrane oxygenator (31) so as to convey the blood in the open blood storage container (10) to the membrane oxygenator (31);
wherein the membrane oxygenator (31) is used for infusing oxygen into the blood and discharging carbon dioxide in the blood.
4. The normothermic oxygenation perfusion apparatus of claim 3, wherein heat exchange tubes are provided inside the membrane oxygenator (31), the thermostatic oxygenation device (30) further comprises:
the constant-temperature heating water tank (32) is provided with a hot water outlet and a water return port, and the hot water outlet and the water return port are correspondingly communicated with two ports of the heat exchange tube in the membrane oxygenator (31) respectively so that hot water in the constant-temperature heating water tank (32) circularly flows through the heat exchange tube to heat blood flowing through the membrane oxygenator (31) to a preset temperature.
5. The normothermic oxygenation perfusion apparatus of claim 3, wherein the thermostatical oxygenation device (30) further comprises:
an oxygen cylinder (33), the oxygen cylinder (33) being in communication with an oxygen inlet port of the membrane oxygenator (31) to supply oxygen to the membrane oxygenator (31).
6. The normothermic oxygenation perfusion apparatus of claim 1, wherein the second arterial circulation line (40) comprises:
an inlet end of the second artery infusion tube (41) is communicated with a first outlet end of the constant temperature oxygenation device (30), and an outlet end of the second artery infusion tube (41) extends into the open blood storage container (10) to be communicated with an artery of the donor organ (60) so as to supply blood to the artery of the donor organ (60).
7. The normothermic oxygenation perfusion apparatus of claim 6, wherein the second arterial circulation line (40) further comprises:
a first flow meter (42) disposed on the second arterial infusion tube (41) to monitor arterial blood flow;
a first flow rate regulating valve (43) provided on the second arterial infusion tube (41) to regulate the arterial blood supply flow rate;
a pressure gauge (44) disposed on the second arterial infusion tube (41) to monitor arterial supply pressure.
8. The normothermic oxygenation perfusion apparatus of claim 1, wherein the venous circulation line (50) comprises:
a first venous transfusion tube (51), wherein the inlet end of the first venous transfusion tube (51) is communicated with the second outlet end of the constant temperature oxygenation device (30);
a closed blood storage container (52), wherein the outlet end of the first intravenous tube (51) is communicated with the inlet end of the closed blood storage container (52) so as to convey the blood from the constant temperature oxygenation device (30) to the closed blood storage container (52) for temporary storage;
a second intravenous tubing line (53), an inlet end of the second intravenous tubing line (53) communicating with an outlet end of the closed blood reservoir (52), an outlet end of the second intravenous tubing line (53) extending into the open blood reservoir (10) to communicate with a vein of the donor organ (60);
an intravenous infusion pump (54) disposed on the second intravenous infusion tube (53), the intravenous infusion pump (54) for generating a pumping force to supply blood to a vein of the donor organ (60).
9. The normothermic oxygenation perfusion apparatus of claim 8, wherein the interior of the enclosed blood storage container (52) is provided with a liquid level sensor (55), the liquid level sensor (55) being used to monitor a liquid level within the enclosed blood storage container (52);
wherein the intravenous infusion pump (54) is adapted to be activated to supply blood to a vein of the donor organ (60) when a liquid level within the closed blood storage container (52) is above a preset minimum liquid level.
10. The normothermic oxygenation perfusion apparatus of claim 8, wherein the venous circulation line (50) further comprises:
a second flow meter (56) disposed on the second intravenous tubing line (53) to monitor venous blood flow;
a second flow regulating valve (57) provided on the second venous transfusion tube (53) to regulate the venous blood flow.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910470826.7A CN112006016A (en) | 2019-05-31 | 2019-05-31 | Normal temperature oxygenation perfusion apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910470826.7A CN112006016A (en) | 2019-05-31 | 2019-05-31 | Normal temperature oxygenation perfusion apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112006016A true CN112006016A (en) | 2020-12-01 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105379707A (en) * | 2015-12-16 | 2016-03-09 | 浙江大学 | Liver normal temperature perfusion restoration system |
| CN106508890A (en) * | 2016-10-28 | 2017-03-22 | 中山大学附属第医院 | Multiple organ storage device |
| CN108432743A (en) * | 2018-06-15 | 2018-08-24 | 广州军区广州总医院 | Portable organ contributes donor machine perfusion system |
| CN109362710A (en) * | 2018-11-28 | 2019-02-22 | 广东丁沃生医疗器械有限公司 | Liver perfusion device |
| CN210352869U (en) * | 2019-05-31 | 2020-04-21 | 西安赛德欧医疗研究院有限公司 | Normal temperature oxygenation perfusion apparatus |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105379707A (en) * | 2015-12-16 | 2016-03-09 | 浙江大学 | Liver normal temperature perfusion restoration system |
| CN106508890A (en) * | 2016-10-28 | 2017-03-22 | 中山大学附属第医院 | Multiple organ storage device |
| CN108432743A (en) * | 2018-06-15 | 2018-08-24 | 广州军区广州总医院 | Portable organ contributes donor machine perfusion system |
| CN109362710A (en) * | 2018-11-28 | 2019-02-22 | 广东丁沃生医疗器械有限公司 | Liver perfusion device |
| CN210352869U (en) * | 2019-05-31 | 2020-04-21 | 西安赛德欧医疗研究院有限公司 | Normal temperature oxygenation perfusion apparatus |
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