CN210610819U - Isolated organ perfusion apparatus - Google Patents

Abstract

The utility model relates to an isolated organ perfusion equipment, include: controlling means and container subassembly, controlling means includes perfusion assembly and controller, perfusion assembly is including being used for providing the first power pump of power of pouring into, first power pump and controller electric connection, container subassembly includes the tray, support membrane and power pump head, it sets up in order to support the isolated organ to support the membrane is fixed, the bottom of tray is equipped with the reservoir that is used for the holding perfusate, the reservoir is equipped with first liquid outlet, set up the through-hole that is used for with the reservoir intercommunication on the support membrane, the power pump head is connected with the output of first power pump, the power pump head is equipped with the first liquid outlet interface that is used for with the first feed liquor interface of first liquid outlet pipeline intercommunication and is used for the first liquid outlet interface that communicates with the arterial line of isolated organ, above-mentioned isolated organ perfusion equipment can realize the long-time preservation of isolated organ under normal atmospheric temperature environment, promote the success rate of transplantation.

Description

Isolated organ perfusion apparatus

Technical Field

The utility model relates to an auxiliary medical instrument technical field especially relates to an isolated organ perfusion equipment.

Background

In the case of organ transplantation, preservation of the organ can directly determine the success or failure of the transplantation operation.

At present, the preservation of isolated organs is generally carried out by adopting a low-temperature static preservation method, namely, the preservation time of the organs is prolonged by reducing the energy consumption of the organs through low temperature.

However, the long-term low temperature environment causes problems such as damage to tissue cells on isolated organs, ischemia of organs, and the like, thereby reducing the success rate of transplantation surgery.

SUMMERY OF THE UTILITY MODEL

Therefore, it is necessary to provide an isolated organ perfusion apparatus for continuously perfusing perfusate to an isolated organ to achieve long-term preservation of the isolated organ at normal temperature, thereby effectively avoiding problems such as damage to tissue cells and organ ischemia caused by low temperature environment, and improving success rate of transplantation.

In order to achieve the above object, the present invention provides an isolated organ perfusion apparatus, the isolated organ perfusion apparatus comprising: controlling means and container subassembly, controlling means includes perfusion assembly and controller, perfusion assembly is including being used for providing the first power pump of filling power, first power pump with controller electric connection, container subassembly includes the tray, supports membrane and power pump head, it is fixed to set up to support the membrane in order to support the separation organ on the tray, the bottom of tray is equipped with the reservoir that is used for the holding perfusate, the reservoir is equipped with first liquid outlet, support set up on the membrane be used for with the through-hole of reservoir intercommunication, the power pump head with the output of first power pump is connected, the power pump head be equipped with be used for with the first feed liquor interface of first liquid outlet pipeline intercommunication with be used for with the first liquid outlet interface of the arterial line intercommunication of separation organ.

Compared with the prior art, the isolated organ perfusion equipment at least has the following beneficial effects: firstly, an isolated organ is placed on a supporting membrane, perfusate is injected into a liquid storage tank, a first liquid inlet interface of a power pump head is communicated with a first liquid outlet of the liquid storage tank through a pipeline, a first liquid outlet interface of the power pump head is communicated with an artery of the isolated organ through a pipeline, then a power supply is switched on, a controller controls a first power pump to operate to drive the perfusate to flow in the pipeline, the perfusate flows out of the first liquid outlet of the liquid storage tank, sequentially flows through the first liquid inlet interface, the first liquid outlet interface and the artery, is discharged outwards from the isolated organ and flows back into the liquid storage tank through a through hole of the supporting membrane, so that the circulating flow of the perfusate is realized, the perfusate is continuously perfused into the isolated organ, the isolated organ is preserved for a long time under a normal temperature environment, and tissue cells caused by a low-temperature environment are effectively prevented from being damaged, Organ ischemia, etc.; meanwhile, the perfusate is driven to circularly flow by the first power pump, so that thrombus, inflammatory factors or other foreign matter harmful substances in the isolated organ can be effectively removed, and functional vessels of the isolated organ can be maintained smooth, pulmonary edema, cardio-pulmonary oxygenation capacity and the like can be improved, the isolated organ can be subjected to repair treatment, the risk of postoperative graft failure is reduced, and the utilization rate of the donor organ and the success rate of transplantation operation are effectively improved.

In one of them embodiment, the isolated organ is the isolated lung, controlling means still includes the breathing subassembly, the breathing subassembly includes the breathing machine, the breathing machine with controller electric connection, the breathing machine is equipped with air feed interface and return-air interface, the air feed interface the trachea of isolated lung with return-air interface pipeline intercommunication forms circulation breathing gas circuit in proper order.

In one embodiment, the breathing assembly further comprises a battery for supplying power to the ventilator.

In one embodiment, the respiratory component further comprises a first operation screen for displaying and inputting respiratory function parameters, and the first operation screen is electrically connected with the controller.

In one of them embodiment, controlling means still includes heat transfer assembly, heat transfer assembly includes thermostated container and second power pump, the thermostated container is used for holding heat transfer liquid, be equipped with in the thermostated container and be used for the heating member of heat transfer liquid, container assembly still include through the tube coupling in first play liquid interface with oxygenator between the artery, the thermostated container with oxygenator passes through the pipeline intercommunication and forms circulation heat transfer pipeline, second power pump is used for providing the power that heat transfer liquid circulation flows, the perfusate is in the oxygenator with heat transfer liquid carries out the heat exchange, second power pump with the heating member all with controller electric connection.

In one embodiment, the perfusion assembly further comprises a first temperature detection module, the first temperature detection module is used for detecting the temperature of the perfusion solution, and the first temperature detection module is electrically connected with the controller.

In one embodiment, the container assembly further comprises a leukocyte filter connected between the oxygenator and the artery by tubing.

In one embodiment, the container assembly further comprises a micro-plug filter connected by tubing between the oxygenator and the artery or between the powered pump head and the oxygenator.

In one embodiment, the control device further includes a second peristaltic pump and a third peristaltic pump, the container assembly further includes a liquid changing mechanism, the liquid changing mechanism includes a dialyzer, a waste liquid tank and a liquid supplementing tank, the liquid storing tank is further provided with a second liquid outlet, the dialyzer is simultaneously communicated with the waste liquid tank, the liquid supplementing tank and the second liquid outlet through pipelines, the second peristaltic pump is used for providing power for the perfusion liquid flowing out of the second liquid outlet to flow into the waste liquid tank and the liquid supplementing tank after flowing through the dialyzer, the liquid supplementing tank is communicated with the liquid storing tank through a pipeline, the third peristaltic pump is arranged on a pipeline between the liquid supplementing tank and the liquid storing tank, and the second peristaltic pump and the third peristaltic pump are both electrically connected with the controller.

In one embodiment, the perfusion assembly further includes a first pressure detection module, the first pressure detection module is configured to detect a pressure of the perfusion fluid flowing into the artery, and the first pressure detection module is electrically connected to the controller.

In one embodiment, the perfusion assembly further comprises a flow detection module, wherein the flow detection module is used for detecting the flow of the perfusion fluid, and the flow detection module is electrically connected with the controller.

In one embodiment, the perfusion assembly further comprises a second operation screen for displaying and inputting perfusion function parameters, and the second operation screen is electrically connected with the controller.

In one embodiment, the priming assembly further comprises a second battery for powering the first powered pump.

In one embodiment, the control device further comprises an alarm module, and the alarm module is electrically connected with the controller.

In one embodiment, the control device further includes a communication module and a mobile terminal, the communication module is electrically connected to the controller, and the mobile terminal is electrically connected to the communication module.

In one embodiment, the support membrane is recessed toward the reservoir.

In one embodiment, the control device further includes a housing, a first inner cavity for accommodating the infusion assembly is formed in the housing, the container assembly is disposed on the housing, an opening for placing the power pump head into the first inner cavity is formed in the housing, and the power pump head is detachably connected to the output end of the first power pump.

In one embodiment, the housing is further provided with a mounting door, and the mounting door corresponds to the first inner cavity in position.

Drawings

Fig. 1 is a schematic structural diagram of an isolated organ perfusion apparatus according to an embodiment of the present invention;

FIG. 2 is a schematic diagram showing the internal structure of a control device in the isolated organ perfusion apparatus shown in FIG. 1;

FIG. 3 is a schematic diagram of the internal structure of a container assembly of the isolated organ perfusion apparatus of FIG. 1;

FIG. 4 is a schematic view of the structure of the tray in the container assembly of FIG. 3;

FIG. 5 is a schematic diagram of the power pump head of the container assembly of the isolated organ perfusion apparatus of FIG. 1;

FIG. 6 is a partial cross-sectional view of a container assembly of the isolated organ perfusion apparatus of FIG. 1;

FIG. 7 is a schematic diagram of the construction of the oxygenator in the container assembly shown in FIG. 3;

FIG. 8 is a schematic view of the leukocyte filter of the container assembly of FIG. 3;

FIG. 9 is a schematic view of the construction of the micro-suppository filter of the container assembly of FIG. 3;

FIG. 10 is a schematic view of a connection structure of a container assembly in the isolated organ perfusion apparatus of FIG. 1;

fig. 11 is a schematic view of a connection structure of a heat exchange assembly in the control device shown in fig. 2.

10. A control device 111, a first power pump, 112, a first temperature detection module, 113, a flow detection module, 114, a second operation screen, 115, a second storage battery, 121, a breathing machine, 1211, an air supply interface, 1212, an air return interface, 1213, an oxygen inlet, 1214, an air inlet, 122, a first operation screen, 131, a thermostat, 1311, a heating element, 1312, a heat exchange liquid inlet, 1313, a heat exchange liquid outlet, 1314, a second temperature detection module, 1315, a drain valve, 132, a second power pump, 14, a housing, 141, an opening, 142, a mounting door, 15, a liquid conveying support rod, 20, a container assembly, 21, a tray, 211, a support membrane, 2111, a through hole, 212, a liquid storage tank, 2121, a pump head, 2122, a second liquid outlet, 22, a power liquid outlet, 221, a first liquid inlet interface, 222, a first liquid outlet interface, 23, a housing, 24, a liquid inlet, a liquid outlet, 241, and a second liquid inlet, 242. the device comprises a second liquid outlet, 243, a heat exchange inlet, 244, a heat exchange outlet, 25, a leukocyte filter, 251, a third liquid inlet, 252, a third liquid outlet, 26, a micro-suppository filter, 261, a fourth liquid inlet, 262, a fourth liquid outlet, 27, a waste liquid tank, 28, a fluid infusion tank, 29, a dialyzer, 30, a second peristaltic pump, 40 and a third peristaltic pump.

Detailed Description

In order to facilitate understanding of the present invention, the present invention will be described more fully hereinafter with reference to the accompanying drawings. The preferred embodiments of the present invention are shown in the drawings. The invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. In contrast, when an element is referred to as being "directly on" another element, there are no intervening elements present. In the present invention, the terms "first", "second", "third" and "fourth" do not denote any particular quantity or order, but are merely used to distinguish names.

As shown in fig. 1 to 5, an isolated organ perfusion apparatus, which is suitable for long-term preservation of isolated organs such as isolated lungs, isolated hearts, etc. in a normal temperature environment and repair of the isolated organs, comprises: the control device 10 and the container assembly 20, the control device 10 includes a perfusion assembly and a controller (not labeled in the drawing), the perfusion assembly includes a first power pump 111 for providing perfusion power, the first power pump 111 is electrically connected with the controller, the container assembly 20 includes a tray 21, a support membrane 211 and a power pump head 22, the support membrane 211 is fixedly disposed on the tray 21 to support the isolated organ, a liquid storage tank 212 for containing perfusion liquid is disposed at the bottom of the tray 21, the liquid storage tank 212 is provided with a first liquid outlet 2121, a through hole 2111 for communicating with the liquid storage tank 212 is disposed on the support membrane 211, the power pump head 22 is connected with an output end of the first power pump 111, and the power pump head 22 is provided with a first liquid inlet 221 for communicating with a first liquid outlet 2121 through a pipeline and a first liquid outlet 222 for communicating with an arterial pipeline of the isolated organ.

In application, firstly, a body organ is placed on the support membrane 211, perfusate is injected into the reservoir 212, then the first liquid inlet interface 221 of the power pump head 22 is communicated with the first liquid outlet 2121 of the reservoir 212 through a pipeline, the first liquid outlet interface 222 of the power pump head 22 is communicated with an artery of the isolated organ through a pipeline, then the power supply is switched on, the controller controls the first power pump 111 to operate to drive the perfusate to flow in the pipeline, the perfusate flows out of the first liquid outlet 2121 of the reservoir 212, sequentially flows through the first liquid inlet interface 221, the first liquid outlet interface 222 and the artery, is finally discharged outwards from the isolated organ and flows back into the reservoir 212 through the through hole 2111 of the support membrane 211, so that the circulating flow of the perfusate is realized, the perfusate is continuously perfusate to the isolated organ, the isolated organ is preserved for a long time under a normal temperature environment, and histiocytes damage and the like caused by the low temperature environment are effectively avoided, Organ ischemia, etc.; meanwhile, the perfusate is driven to circularly flow by the first power pump 111, so that thrombus, inflammatory factors or other foreign matter harmful substances in the isolated organ can be effectively removed, functional vessels of the isolated organ can be maintained smooth, pulmonary edema, cardio-pulmonary oxygenation capacity and the like can be improved, the isolated organ can be subjected to repair treatment, the risk of postoperative graft loss is reduced, and the utilization rate of the donor organ and the success rate of transplantation operation are effectively improved.

Specifically, referring to fig. 3, the through holes 2111 are multiple, and the through holes 2111 are uniformly distributed on the supporting film 211.

Specifically, with continued reference to fig. 3, the container assembly 20 further includes a housing 23, and the tray 21 and the support membrane 211 are disposed within the housing 23 to seal the body organ.

Specifically, the perfusate is prepared by mixing DMEM/F12 culture medium components, albumin and ficoll 70 in proportion.

In an embodiment, please refer to fig. 1 and fig. 2, the isolated organ is an isolated lung, the control device 10 further includes a breathing assembly, the breathing assembly includes a breathing machine 121, the breathing machine 121 is electrically connected to the controller, the breathing machine 121 is provided with an air supply interface 1211 and an air return interface 1212, and the air supply interface 1211, an air tube of the isolated lung and the air return interface 1212 are sequentially connected to form a circulating breathing air path through a pipeline. The isolated lung both needs perfusion liquid when keeping, also needs oxygen to supply simultaneously, and after the switch on, the controller controls simultaneously that to pour into first power pump 111 and breathing machine 121 and start, and first power pump 111 is when carrying the perfusion liquid to the isolated lung, through communicating the trachea pipeline with breathing machine 121 and isolated lung, continuously supplies oxygen for the isolated lung to keep the isolated lung to carry out the motion of spreading again.

Specifically, referring to fig. 2, the ventilator 121 is further provided with an oxygen inlet 1213 and an air inlet 1214, the oxygen inlet 1213 is used for communicating with an oxygen source (not shown in the drawings) through a pipeline, the air inlet 1214 is used for communicating with an air compressor (not shown in the drawings) through a pipeline, and the oxygen and the air are mixed in proportion to form a mixed gas which is then supplied to the isolated lung to maintain the isolated lung to perform a reciprocating motion.

Further, with continued reference to fig. 2, the breathing assembly further includes a first battery (not shown in the drawings) for supplying power to the ventilator 121, wherein the first battery may be a lithium battery, a cadmium-nickel battery or a hydrogen-nickel battery, and particularly, to ensure that the power can be continuously and stably supplied, the first battery is preferably a lithium battery. Under the circumstances of having a power failure or in the isolated organ transportation process, first battery can regard as the power to supply power to breathing machine 121 to guarantee that breathing machine 121 continuously operates, thereby make isolated lung keep carrying out the motion of expanding again, effectively avoid isolated lung to take place because of the condition that the respiratory function stops and cause the damage.

Further, with reference to fig. 1, the respiratory component further includes a first operation panel 122 for displaying and inputting respiratory function parameters, and the first operation panel 122 is electrically connected to the controller. The user can input corresponding respiratory function parameter on first operation screen 122 according to the experiment needs, and the work of breathing machine 121 is controlled according to above-mentioned respiratory function parameter to the controller, effectively improves the simple operation nature.

In an embodiment, referring to fig. 2, fig. 3 and fig. 11, the control device 10 further includes a heat exchange assembly, the heat exchange assembly includes a thermostat 131 and a second power pump 132, the thermostat 131 is configured to receive a heat exchange liquid, a heating element 1311 is disposed in the thermostat 131 and configured to heat the heat exchange liquid, the container assembly 20 further includes an oxygenator 24 connected between the first liquid outlet and the artery through a pipeline, the thermostat 131 is communicated with the oxygenator 24 through a pipeline to form a circulating heat exchange pipeline, the second power pump 132 is configured to provide power for circulating the heat exchange liquid, the perfusion liquid exchanges heat with the heat exchange liquid in the oxygenator 24, and both the second power pump 132 and the heating element 1311 are electrically connected to the controller. With reference to fig. 11, the incubator 131 is connected to the oxygenator 24 through a pipeline to form a circulating heat exchange pipeline, the power pump head 22, the oxygenator 24, the isolated organ and the liquid storage tank 212 are connected to form a circulating perfusion pipeline, and the perfusate exchanges heat with the heat exchange fluid in the oxygenator 24 to keep the temperature of the perfusate suitable for the isolated organ.

Specifically, referring to fig. 1 and fig. 7, the incubator 131 is provided with a heat exchange liquid inlet 1312 and a heat exchange liquid outlet 1313, the oxygenator 24 is provided with a second liquid inlet interface 241, a second liquid outlet interface 242, a heat exchange inlet 243 and a heat exchange outlet 244, the first liquid outlet 2121 of the liquid storage tank 212, the first liquid inlet interface 221 of the power pump head 22, the first liquid outlet interface 222 of the power pump head 22, the second liquid inlet interface 241, the second liquid outlet interface 242 and the isolated organ artery are sequentially communicated with each other to form the above-mentioned circulation perfusion pipeline, and the heat exchange liquid outlet 1313, the heat exchange inlet 243, the heat exchange outlet 244 and the heat exchange liquid inlet 1312 are sequentially communicated with each other to form the above-mentioned circulation heat exchange pipeline.

In particular, the heat exchange liquid can be selected from sterile deionized water.

In an embodiment, please refer to fig. 2, the perfusion assembly further includes a first temperature detection module 112, the first temperature detection module 112 is configured to detect a temperature of the perfusion fluid, and the first temperature detection module 112 is electrically connected to the controller. The first temperature detection module 112 detects the temperature of the perfusate in real time and feeds back temperature data to the controller, and when the temperature of the perfusate is detected to deviate from the set temperature, the controller adjusts the heating power of the heating element 1311 so as to enable the perfusate to return to the set temperature, and further ensure that the temperature of the perfusate is appropriate to the isolated organ.

Further, please refer to fig. 11, a second temperature detecting module 1314 is disposed in the incubator 131, the second temperature detecting module 1314 is electrically connected to the controller, the second temperature detecting module 1314 detects the temperature of the heat-exchanging fluid in real time and feeds back the temperature data to the controller, and when the temperature of the heat-exchanging fluid is detected to deviate from the set temperature, the controller adjusts the heating power of the heating element 1311 to return the heat-exchanging fluid to the set temperature, thereby further ensuring that the temperature of the heat-exchanging fluid is suitable for the isolated organ.

Specifically, please refer to fig. 11, the incubator 131 is further provided with a drain valve 1315, and after the isolated organ perfusion operation is completed, the drain valve 1315 can be opened to discharge the heat exchange liquid in the incubator 131 to the outside, so as to avoid bacterial growth caused by long-term closed storage.

In one embodiment, referring to fig. 3, the container assembly 20 further includes a leukocyte filter 25, and the leukocyte filter 25 is connected between the oxygenator 24 and the artery through a pipeline. The perfusate flows out of the oxygenator 24 and enters the leukocyte filter 25 for leukocyte filtration, so that the damage of the isolated organ caused by perfusing the perfusate is effectively reduced, the occurrence of rejection reaction of organ transplantation can be effectively delayed, and the utilization rate of donor organs and the success rate of transplantation operations are further improved.

Specifically, referring to fig. 8 and 10, the leukocyte filter 25 has a third fluid inlet 251 and a third fluid outlet 252, the third fluid inlet 251 is in communication with the second fluid outlet 242, and the third fluid outlet 252 is in communication with the arterial line of the isolated organ.

In one embodiment, referring to fig. 3, the container assembly 20 further includes a micro-plug filter 26, the micro-plug filter 26 is connected between the oxygenator 24 and the artery or between the power pump head 22 and the oxygenator 24 by a pipeline. The perfusion fluid enters the micro-suppository filter 26 before flowing into the oxygenator 24 or after flowing out of the oxygenator 24, and the micro-suppository filter 26 is used for filtering various micro-suppositories in the perfusion fluid, preventing the micro-blood vessels of the isolated organ from being embolized due to various micro-suppositories such as thrombus or air embolism and the like, effectively improving the blood perfusion of the micro-blood vessels of the human body, and further improving the utilization rate of the donor organ and the success rate of the transplantation operation.

Specifically, referring to fig. 9 and 10, the microembolus filter 26 has a fourth inlet port 261 and a fourth outlet port 262, the fourth inlet port 261 is in pipeline communication with the second outlet port 242, and the fourth outlet port 262 is in pipeline communication with the artery of the isolated organ.

Further, please refer to fig. 3, which combines the two aforementioned embodiments, the leukocyte filter 25 and the micro-suppository filter 26 are connected between the oxygenator 24 and the isolated organ at the same time, wherein the connection sequence between the leukocyte filter 25 and the micro-suppository filter 26 is not limited, so as to further improve the utilization rate of the isolated organ and the success rate of the transplantation operation.

In an embodiment, referring to fig. 6 and 10, the control device 10 further includes a second peristaltic pump 30 and a third peristaltic pump 40, the container assembly 20 further includes a liquid changing mechanism, the liquid changing mechanism includes a dialyzer 29, a waste liquid tank 27 and a liquid replenishing tank 28, the liquid storing tank 212 further includes a second liquid outlet 2122, the dialyzer 29 is simultaneously in pipeline communication with the waste liquid tank 27, the liquid replenishing tank 28 and the second liquid outlet 2122, the second peristaltic pump 30 is configured to provide a motive force for a perfusion liquid flowing out from the second liquid outlet 2122 to flow through the dialyzer 29 and then enter the waste liquid tank 27 and the liquid replenishing tank 28, the liquid replenishing tank 28 is in pipeline communication with the liquid storing tank 212, the third peristaltic pump 40 is disposed on a pipeline between the liquid replenishing tank 28 and the liquid storing tank 212, and both the second peristaltic pump 30 and the third peristaltic pump 40 are electrically connected to the controller. The perfusion liquid after multiple cycles flows out from the second liquid outlet 2122 of the liquid storage tank 212, after the perfusion liquid flows through the dialyzer 29 under the drive of the second peristaltic pump 30, one part of the perfusion liquid flows into the waste liquid tank 27, the other part of the perfusion liquid is converged into one path with the new perfusion liquid flowing out of the liquid supplement tank 28 under the drive of the third peristaltic pump 40 and flows into the liquid storage tank 212, so that the supplement and replacement of the perfusion liquid are realized, and the controller controls the rotating speed of the second peristaltic pump 30 and the third peristaltic pump 40 to ensure that the volume of the perfusion liquid in the liquid storage tank 212 is constant.

In one embodiment, the perfusion assembly further includes a first pressure detection module (not shown in the drawings) for detecting a pressure of the perfusion fluid flowing into the artery, and the first pressure detection module is electrically connected to the controller. The first pressure detection module detects the pressure of the perfusate flowing into the artery in real time and feeds pressure data back to the controller, and the controller controls the power of the first power pump 111 according to the pressure data to control the perfusion pressure of the perfusate, avoid the perfusion pressure and the isolated organ to be unsuitable and cause the arterial injury of the isolated organ, further promote the utilization ratio of the donor organ and the success rate of the transplantation operation.

In an embodiment, please refer to fig. 2, the perfusion assembly further includes a flow detection module 113, the flow detection module 113 is configured to detect a flow of the perfusion fluid, and the flow detection module 113 is electrically connected to the controller. The flow detection module 113 detects the flow of the perfusate in real time and feeds the flow data back to the controller, and the controller controls the power of the first power pump 111 according to the flow data to control the flow of the perfusate.

In an embodiment, please refer to fig. 1, the perfusion assembly further includes a second operation screen 114 for displaying and inputting perfusion function parameters, and the second operation screen 114 is electrically connected to the controller. The user can input corresponding function parameter of infusing on second operation screen 114 according to the experiment needs, and the first power pump 111 work of controller control according to above-mentioned function parameter of infusing effectively improves the simple operation nature.

In one embodiment, please refer to fig. 2, the perfusion assembly further includes a second battery 115 for supplying power to the first power pump 111, wherein the second battery 115 can be a lithium battery, a cadmium nickel battery or a hydrogen nickel battery, and particularly, the second battery 115 is preferably a lithium battery to ensure that the power can be continuously and stably supplied. Under the circumstances of having a power failure or in the isolated organ transportation process, second battery 115 can regard as the power to first power pump 111 power supply to guarantee that first power pump 111 lasts the operation, thereby guarantee to last to isolated organ perfusion perfusate, effectively avoid isolated organ to take place because of the condition of perfusion function stop and cause the damage.

In one embodiment, the control device 10 further includes an alarm module (not shown in the drawings), and the alarm module is electrically connected to the controller. When the controller identifies work abnormality according to the acquired parameter data, the alarm module is started to inform a user to take corresponding measures in time, so that the injury of isolated organs caused by long-time work abnormality is avoided, and the utilization rate of donor organs and the success rate of transplantation operations are further improved.

In an embodiment, the control device 10 further includes a communication module (not shown in the drawings) and a mobile terminal (not shown in the drawings), wherein the communication module is electrically connected to the controller, and the mobile terminal is electrically connected to the communication module. Wherein, communication module can be the thing networking module, can include but not limited to WIFI module, GPRS module, 3G module, 4G module etc. and communication module uploads the produced relevant data of isolated organ perfusion in-process to the database in the cloud ware, and transplantation expert's accessible mobile terminal looks over above-mentioned data to convenient the isolated organ regularly guardianship and aassessment isolated organ condition to guarantee that isolated organ function obtains effective the preserving for a long time.

In an embodiment, referring to fig. 3, the supporting film 211 is recessed toward the reservoir 212 to provide more storage space for the isolated organ, so as to prevent the isolated organ from being damaged due to compression during the perfusion process, and particularly, the supporting film 211 may be an elastic soft film, such as a silicone film, to further prevent the isolated organ from being damaged.

In one embodiment, referring to fig. 1, the control device 10 further includes a housing 14, a first inner cavity (not shown) for accommodating the perfusion assembly is formed in the housing 14, the container assembly 20 is disposed on the housing 14, an opening 141 for inserting the power pump head 22 into the first inner cavity is formed in the housing 14, and the power pump head 22 is detachably connected to the output end of the first power pump 111. When the device is installed, the power pump head 22 penetrates from the opening 141 and then is connected with the first power pump 111 for installation, during the perfusion process, perfusate does not contact the control device 10, after the perfusion operation is completed, the power pump head 22 can be detached from the first power pump 111, so that the container assembly 20 is detached from the control device 10 and discarded, when the perfusion operation of the next isolated organ is performed, the container assembly 20 which is replaced by a new one can be installed and connected with the control device 10, the complete replacement of the isolated organ after the perfusion operation is completed every time is avoided, and the use cost is effectively reduced.

Specifically, a second inner cavity (not shown in the drawings) for accommodating the breathing assembly and a third inner cavity (not shown in the drawings) for accommodating the heat exchange assembly are also provided in the housing 14.

In an embodiment, referring to fig. 1, the housing 14 is further provided with a mounting door 142, the mounting door 142 corresponds to the first inner cavity, and a user can open the mounting door 142 to connect the power pump head 22 and the first power pump 111, so as to improve the convenience of use.

Specifically, please refer to fig. 2, an infusion support rod 15 is further disposed on the housing 14, and the infusion support rod 15 is used for hanging bottled drugs, surgical instruments, and the like, so as to further improve the convenience of use. Particularly, the infusion support rod 15 can be a telescopic rod to adapt to different height requirements through telescopic adjustment, and the use convenience is further improved.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only represent some embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several variations and modifications can be made, which are within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.

Claims (18)

1. An ex vivo organ perfusion apparatus, comprising: controlling means and container subassembly, controlling means includes perfusion assembly and controller, perfusion assembly is including being used for providing the first power pump of filling power, first power pump with controller electric connection, container subassembly includes the tray, supports membrane and power pump head, it is fixed to set up to support the membrane in order to support the separation organ on the tray, the bottom of tray is equipped with the reservoir that is used for the holding perfusate, the reservoir is equipped with first liquid outlet, support set up on the membrane be used for with the through-hole of reservoir intercommunication, the power pump head with the output of first power pump is connected, the power pump head be equipped with be used for with the first feed liquor interface of first liquid outlet pipeline intercommunication with be used for with the first liquid outlet interface of the arterial line intercommunication of separation organ.

2. The isolated organ perfusion apparatus according to claim 1, wherein the isolated organ is an isolated lung, the control device further comprises a breathing assembly, the breathing assembly comprises a breathing machine, the breathing machine is electrically connected to the controller, the breathing machine is provided with an air supply interface and an air return interface, and the air supply interface, an air tube of the isolated lung and the air return interface are sequentially communicated through a pipeline to form a circulating breathing air path.

3. An ex vivo organ perfusion apparatus according to claim 2, wherein the respiration assembly further comprises a battery for powering the ventilator.

4. The isolated organ perfusion apparatus of claim 2, wherein the respiratory assembly further comprises a first operation screen for displaying and inputting respiratory function parameters, the first operation screen being electrically connected to the controller.

5. The isolated organ perfusion apparatus of claim 1, wherein the control device further comprises a heat exchange assembly, the heat exchange assembly comprises a thermostat and a second power pump, the thermostat is used for accommodating a heat exchange liquid, a heating element is arranged in the thermostat and used for heating the heat exchange liquid, the container assembly further comprises an oxygenator connected between the first liquid outlet and the artery through a pipeline, the thermostat and the oxygenator are communicated through a pipeline to form a circulating heat exchange pipeline, the second power pump is used for providing power for circulating flow of the heat exchange liquid, the perfusion liquid exchanges heat with the heat exchange liquid in the oxygenator, and the second power pump and the heating element are both electrically connected with the controller.

6. The isolated organ perfusion apparatus of claim 5, wherein the perfusion assembly further comprises a first temperature detection module for detecting a temperature of the perfusate, the first temperature detection module being electrically connected to the controller.

7. The isolated organ perfusion apparatus of claim 5, wherein the container assembly further comprises a leukocyte filter connected between the oxygenator and the artery by tubing.

8. The isolated organ perfusion apparatus of claim 5, wherein the container assembly further comprises a micro-plug filter connected by tubing between the oxygenator and the artery or between the powered pump head and the oxygenator.

9. The isolated organ perfusion apparatus according to claim 1, wherein the control device further comprises a second peristaltic pump and a third peristaltic pump, the container assembly further comprises a liquid changing mechanism, the liquid changing mechanism comprises a dialyzer, a waste liquid tank and a liquid supplementing tank, the liquid storage tank is further provided with a second liquid outlet, the dialyzer is simultaneously communicated with the waste liquid tank, the liquid supplementing tank and the second liquid outlet through pipelines, the second peristaltic pump is used for providing power for the perfusion liquid flowing out of the second liquid outlet to flow into the waste liquid tank and the liquid supplementing tank after flowing through the dialyzer, the liquid supplementing tank is communicated with the liquid storage tank through a pipeline, the third peristaltic pump is arranged on a pipeline between the liquid supplementing tank and the liquid storage tank, and the second peristaltic pump and the third peristaltic pump are both electrically connected with the controller.

10. The isolated organ perfusion apparatus of any one of claims 1-9, wherein the perfusion assembly further comprises a first pressure detection module configured to detect a pressure of the perfusion fluid flowing into the artery, the first pressure detection module being electrically connected to the controller.

11. The isolated organ perfusion apparatus of any one of claims 1-9, wherein the perfusion assembly further comprises a flow detection module for detecting the flow of the perfusate, the flow detection module being electrically connected to the controller.

12. The isolated organ perfusion apparatus of any one of claims 1-9, wherein the perfusion assembly further comprises a second operation screen for displaying and inputting perfusion function parameters, the second operation screen being electrically connected to the controller.

13. An ex vivo organ perfusion apparatus according to any of claims 1 to 9, wherein the perfusion assembly further comprises a second accumulator for supplying power to the first powered pump.

14. The isolated organ perfusion apparatus of any one of claims 1-9, wherein the control device further comprises an alarm module, and the alarm module is electrically connected to the controller.

15. The isolated organ perfusion apparatus according to any one of claims 1-9, wherein the control device further comprises a communication module and a mobile terminal, the communication module is electrically connected to the controller, and the mobile terminal is electrically connected to the communication module.

16. The isolated organ perfusion apparatus according to any one of claims 1-9, wherein the support membrane is recessed adjacent the reservoir.

17. An isolated organ perfusion apparatus according to any one of claims 1 to 9, wherein the control means further comprises a housing, the housing defining a first interior chamber for receiving the perfusion assembly, the container assembly being disposed on the housing, the housing defining an opening for insertion of the power pump head into the first interior chamber, the power pump head being detachably connected to the output of the first power pump.

18. The isolated organ perfusion apparatus of claim 17, wherein the housing further comprises a mounting door positioned to correspond to the first lumen.

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