CN106508890A - Multi-organ preservation device - Google Patents

Multi-organ preservation device Download PDF

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Publication number
CN106508890A
CN106508890A CN201610973638.2A CN201610973638A CN106508890A CN 106508890 A CN106508890 A CN 106508890A CN 201610973638 A CN201610973638 A CN 201610973638A CN 106508890 A CN106508890 A CN 106508890A
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CN
China
Prior art keywords
outlet
multiple organ
organ
flow control
water bath
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610973638.2A
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Chinese (zh)
Inventor
何晓顺
郭志勇
张林安
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Singularity Medical Technology Guangzhou Co ltd
Original Assignee
First Affiliated Hospital of Sun Yat Sen University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by First Affiliated Hospital of Sun Yat Sen University filed Critical First Affiliated Hospital of Sun Yat Sen University
Priority to CN201610973638.2A priority Critical patent/CN106508890A/en
Priority to DE212017000016.3U priority patent/DE212017000016U1/en
Priority to JP2018600005U priority patent/JP3223817U/en
Priority to AU2017101824A priority patent/AU2017101824A4/en
Priority to PCT/CN2017/072740 priority patent/WO2018076567A1/en
Publication of CN106508890A publication Critical patent/CN106508890A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • A01N1/0236Mechanical aspects
    • A01N1/0242Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts

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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • External Artificial Organs (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention discloses a multi-organ preservation device, wherein a liver is stored in a water bath box to preserve different organs through an independent multi-organ container, blood enters an oxygenation device after being powered by a peristaltic pump, and oxygen in an oxygen bottle enters the oxygenation device to be fused with the blood. After the blood oxygen is fully oxygenated, the medicine pusher pushes the medicines or nutrients in the liver to enter the blood vessels and mix with the blood to enter the organs through the arteries. The blood flows back to the filter after passing through each organ, and bubbles, impurities and the like in the blood flow back to the peristaltic pump after being filtered by the filter. The flow and the flow rate of the inflow pipe are controlled and adjusted by the flow control valve. The device has simple structure and convenient operation, and can preserve isolated organs for a long time.

Description

Multiple organ save set
Technical field
The present invention relates to a kind of new organ preservation system, more particularly to a kind of multiple organ save set.
Background technology
The purpose of organ transplant is that instead of because of fatal disease and the organ of loss of function, transplanted physical efficiency is gathered around again There are corresponding organ, and normal work.Conventional transplant organ have kidney, the heart, liver, pancreas and pancreas islet, parathyroid gland, cardiopulmonary, marrow, Cornea etc..Typically originate and other people in the organs of living beings wanted needed for organ transplant, organ needs from the human body of source to cut down Come, (at least a few minutes, at most less than 1 hour) will be dead in a short time for the in vitro ischemic organ for cutting, it is impossible to for moving Plant, and it is impossible for transfer operation will being completed within the so very brief time.Therefore, to try to keep the activity of organ, protect Card organ leave source human body in organ transfer operation.
At present relatively common is Cryopreservation, low temperature static store method by low temperature reduction organ energy consumption, from And extend the organ holding time, but low temperature intelligently slows down cell death speed, it is impossible to cell death is prevented, meanwhile, low temperature Histiocytic infringement may be caused.
Patent 201410384703.9 discloses the kidney being kept in existence device of a kind of low temperature or subnormal temperature, and which has begun to examine Worry carries out organ preservation under subnormal temperature, improves the preservation quality of kidney.Patent 201410016261.2 discloses a kind of preservation The device and store method of isolated organ, which is by way of machine perfusion and membrane oxygenation makes isolated organ obtain lasting supporting Divide and oxygen supply..Patent 201510085562.5 discloses a kind of security protection enhancement mode organ hypothermia machine perfusion and preserves Device, the device carry out organ preservation at low temperature, while realizing different fill-up modes by the various control signals of pump.Specially Sharp 201310723787.X discloses a kind of transplant organ protective bag, and the apparatus structure is simple, but the device also can only be low Organ preservation is carried out under temperature, it is impossible to provide oxygen and blood circulation.Above patent is preserved just for a kind of organ, nothing Method preserves multiple or various organs simultaneously.
By hemoperfusion, outward plus oxygen, the supply of nutrient content, a healthy tissue is simulated, can not only Enough long-times preserve human organ, also have repair particularly with organs such as livers.
The content of the invention
It is an object of the invention to overcome the shortcomings of prior art, there is provided the good many devices of a kind of simple structure, operability Official's save set.
In order to achieve the above object, the technical solution used in the present invention is:
Multiple organ save set, including go-cart, are provided with multiple organ in described go-cart and preserve equipment, described many devices Official preserves equipment to be included:
One water bath, is placed with a multiple organ container in described water bath, sets in described multiple organ container At least 4 separate slots are equipped with, each separate slot is used for placing different organs, and the bottom of the separate slot described in whole is mutually connected by pipeline It is logical, a separate slot outlet is provided with any one of separate slot bottom, have a jar in described multiple organ container upper cover, Before and after described jar, both sides are fastened with the sealing of multiple organ container by two symmetrically arranged jar buckles respectively, The outside of described jar is covered with an antiseptic cover, and described antiseptic cover is closely detained with many jars by antiseptic cover buckle Close, temperature sensor is installed in described water bath;
One oxygenation device, the import of described oxygenation device are connected with the outlet of peristaltic pump by pipeline, an oxygen The outlet of gas cylinder is connected with the import of oxygenation device by oxygen channel, and the outlet of described oxygenation device is total with a conveying Pipeline is connected, and the outlet of multiple medicine pushers is pushed pipeline by medicine respectively and is connected with described delivery main road, institute The outlet in the delivery main road stated is divided into multiple branch roads, and an inlet flow control valve is provided with each branch road, described Each branch road the port of export pass through water bath and multiple organ container and with multiple organ container each groove in histoorgan Arteries is connected one by one, and described separate slot outlet is connected with outlet conduit, and the outlet conduit is through water bath and many Organ container is simultaneously connected with the outlet header of an outlet for being connected with outlet flow control valves, filter and peristaltic pump in turn Logical, the filtrate (liquid of the filter is less than the liquid level in multiple organ container;
At least 3 have graduated organ secretion container, and for collecting organ secretion, each organ container is led to respectively Cross the organ that the secretion outlet conduit through water bath is connected in each separate slot of the multiple organ container and secrete property management accordingly On road;
One touch display screen, described touch display screen are connected with controller, are exported by described touch display screen Control signal to controller and read, the signal of display controller output, described controller controlled with peristaltic pump, inlet flow rate Valve, outlet flow control valves and temperature sensor are respectively connected with, and described controller reads the signal root of temperature sensor Bath cabinet feed water to heat to the water in water bath according to the temperature signal output temperature control signal, described controller reads The signal of inlet flow control valve and outlet flow control valves, then exports rotation control signal to peristaltic pump.
Compared with prior art, the multiple organ save set that the present invention is provided has the advantages that:
1. the multiple organ save set of the present invention, simple structure are easy to operate, can preserve isolated organ for a long time, very Organ can extremely be repaired.
2. the multiple organ save set of the present invention can be preserved simultaneously and repair the organs such as liver, kidney, pancreas, at most can be same Tetra- organs of Shi Baocun, can substantially carry out organ utilization.
The multiple organ save set of 3 present invention carries out blood flow supply, flow control valve by control peristaltic pump to be carried out Flow and pressure are adjusted, and can ensure that suitable blood flow supply in operation, by oxygen, medicine or nutrients Matter is supplied, and increases Liver Allograft Preservation time and repairing quality.
4. the multiple organ save set of the present invention, by the temperature of controller Based Intelligent Control water bath, ensure that liver Preserved at desired temperatures and repaired, farthest prevent under improper temperature conditions, causing the infringement of liver.
5. the multiple organ save set of the present invention, is the form of a go-cart, facilitates doctor or relevant staff to enter Row movement, when taking organ flexibly, is also used as the training system of experiment made on the living.
Description of the drawings
Fig. 1 is the multiple organ save set principle schematic of the present invention;
Fig. 2 is the structural representation of the multiple organ save set of the front viewing angle of the present invention;
Fig. 3 is the structural representation of the multiple organ save set of the posterior view point of the present invention.
Specific embodiment
Describe the present invention with reference to specific embodiments and the drawings.
The as shown in drawings multiple organ save set of the present invention, including go-cart, when organ in need is gathered and is transported In whole process, can be push by staff and carry out the collection of organ, be transported and make some show and simple operation and Experiment.Multiple organ is installed in described go-cart and preserves equipment, described multiple organ preserves equipment to be included:
One water bath 300, water bath 300 can apply the product of commercialization use the product for customizing, greatly It is little to determine according to actual needs, a multiple organ container 108 is placed with described water bath, in described multiple organ container At least 4 separate slots are provided with 108, each separate slot is used for placing different organs.The bottom of the separate slot described in whole is by pipe Road communicates with one another, and is provided with a separate slot outlet in any one of separate slot bottom, is stamped on described multiple organ container 108 One jar 109, before and after described jar 109 both sides respectively by two symmetrically arranged jar buckles 113 with The sealing of multiple organ container 108 is fastened, it is ensured that organ does not fall out multiple organ jar 109 in transportation.In described appearance The outside of device cover 109 is covered with an antiseptic cover 111, and described antiseptic cover 111 passes through antiseptic cover buckle 112 and many jars 108 Closely fasten, prevent bacterium from entering inside multiple organ container 108;Temperature sensor is installed in described water bath;
One oxygenation device 103, the import of described oxygenation device 103 are connected with the outlet of peristaltic pump 116 by pipeline Logical, the outlet of an oxygen cylinder 102 is connected with the import of oxygenation device 103 by oxygen channel.Described oxygenation device 116 Outlet be connected with a delivery main road, the outlet of multiple medicine pushers 101 respectively by medicine push pipeline with it is described Delivery main road be connected, the outlet in described delivery main road is divided into multiple branch roads, on each branch road is provided with one Individual inlet flow control valve 107-1, the port of export of each described branch road pass through water bath 300 and multiple organ container 108 And connected with the histoorgan arteries in multiple organ container 108 each groove one by one, described separate slot outlet and outlet conduit It is connected, the outlet conduit passes through water bath 300 and multiple organ container 108 and is connected with rate of discharge control in turn with one The outlet header of the outlet of valve 107-2 processed, filter 120 and peristaltic pump 116 is connected.Described filter 120 is installed should This is slightly lower, to guarantee the filter filtrate (liquid less than the liquid level in multiple organ container 108.Inlet flow control valve can lead to Cross regulation manually or motorized adjustment to control blood flow size.
At least 3 have graduated organ secretion container 115, for collecting the secretion of the organs such as urine, bile, pancreatic juice Thing, it is each that each organ container is connected to the multiple organ container 108 by the secretion outlet conduit through water bath 300 respectively Organ in separate slot is secreted in conduit (such as bile duct of secretion of bile etc.) accordingly;
One touch display screen 105, described touch display screen 105 are connected with controller 200, aobvious by described touch 105 output control signal of display screen to controller and read, the signal of display controller output, described controller 200 with wriggle Pump, inlet flow control valve 107-1, outlet flow control valves 107-2 and temperature sensor are respectively connected with, described controller 200 signals for reading temperature sensor simultaneously feed water bath cabinet 300 with to water bath according to the temperature signal output temperature control signal In water heated, described controller 200 reads inlet flow control valve 107-1's and outlet flow control valves 107-2 Signal, then exports rotation control signal to peristaltic pump.
As one kind of the invention preferred embodiment, described go-cart includes the upper mounting plate being arranged on go-cart base plate 124, handlebar 110 is fixed with the left of described upper mounting plate 124, four wheels 114 are connected with described go-cart base plate. Central dividing plate 121 and right side partition 122, multiple medicine pushers are separately installed with right side in the middle of described upper mounting plate 124 101 (installation numbers of medicine pusher 101 can according to the actual requirements depending on) and oxygen cylinder 102 are arranged on described right side partition On upper mounting plate 124 on the right side of in the of 122, described oxygen cylinder 102 is fixed on right side by oxygen cylinder fixing band 123 and connects on dividing plate 122, Ensure that oxygen cylinder 102 is maintained static.Described peristaltic pump 116, oxygenation device and filter 120 are in described central dividing plate 121 Set gradually before and after between right side partition 122, described peristaltic pump 116 is fixed on upper mounting plate 124 and by central dividing plate 121 clamp restriction with right side partition 122 rocks.Described 103 Suspending fixation of oxygenation device is connected to the oxygenation device of a U-shaped On connecting plate 104, the U-shaped two ends of oxygenation device connecting plate are separately fixed in central dividing plate 121 and right side partition 122.Institute The filter 120 stated is fixedly connected on central dividing plate 121 by filter mounting 118, described inlet flow control valve 107-1 is fixedly mounted on the top surface of described central dividing plate 121, and described water bath 300 is fixedly mounted on central dividing plate 121 On the upper mounting plate 124 in left side, described organ secretion container 115 is arranged on the upper mounting plate 124 on front side of multiple organ container 108 On.Described touch display screen 105 is fixed on rear side of upper mounting plate 124 by touch display screen connecting bracket 106.
Described inlet flow control valve and outlet flow control valves adopt mechanical type manual valve or described import Flow control valve and outlet flow control valves adopt electric control valve.
Fig. 1 is the principle schematic of multiple organ save set, and each organ is stored in multiple organ container 108, blood Jing Peristaltic pump 116 enters oxygenation device 103 after providing power, the oxygen in oxygen cylinder 102 enters oxygenation device 116 and blood oxygen Close.After oxygen is closed, blood flows into each organ, and medicine pusher 101 pushes the medicine or nutriment of liver and mixes laggard with blood Enter in each dirty body body.Into each organ blood flow and size by respective inlet flow control valve 107-1 controlling, Blood is back to filter 120 Jing after each organ, and the flow and pressure of backflow are adjusted by outlet flow control valves 107-2, blood Bubble in liquid is floating and impurity etc. flows back to peristaltic pump 116 after filter 120 is filtered again.In use, can be according to making With requiring on the pipeline of blood for flowing into each organ clamp pressure and flow sensor measurement pressure, flow be transferred to control Temperature signal in device processed 200 and water bath 300 etc. is connected in controller 200 also by sensor, 200 basis of controller Need to adjust the water temperature in water bath 300, while according to the rotating speed that peristaltic pump 116 is adjusted under the guidance of each parameter and doctor.Doctor Life can pass through touch display screen 105 to be carried out the setting of multiple organ save set and can see that all parts operation conditions is believed Breath.
Below schematically the present invention and embodiments thereof are described, the description does not have restricted, institute in accompanying drawing The several embodiments of the simply present invention for showing, actual structure are also not limited thereto.If those skilled in the art receives Its enlightenment, in the case of without departing from the invention objective, structure, transmission and installation and the connection side for taking other form Formula all should belong to the protection model of the present invention without the creative design frame mode similar to the technical scheme and embodiment Enclose.

Claims (4)

1. multiple organ save set, it is characterised in that:Including go-cart, multiple organ is installed in described go-cart and preserves equipment, Described multiple organ preserves equipment to be included:
One water bath, is placed with a multiple organ container in described water bath, is provided with described multiple organ container At least 4 separate slots, each separate slot are used for placing different organs, and the bottom of the separate slot described in whole is communicated with one another by pipeline, A separate slot outlet is provided with any one of separate slot bottom, has a jar in described multiple organ container upper cover, Before and after described jar, both sides are fastened with the sealing of multiple organ container by two symmetrically arranged jar buckles respectively, in institute The outside of the jar stated is covered with an antiseptic cover, and described antiseptic cover is closely fastened with many jars by antiseptic cover buckle, Temperature sensor is installed in described water bath;
One oxygenation device, the import of described oxygenation device are connected with the outlet of peristaltic pump by pipeline, an oxygen cylinder Outlet be connected with the import of oxygenation device by oxygen channel, outlet and a delivery main road of described oxygenation device It is connected, the outlet of multiple medicine pushers is pushed pipeline by medicine respectively and is connected with described delivery main road, described The outlet in delivery main road is divided into multiple branch roads, and an inlet flow control valve is provided with each branch road, and described is every The port of export of one branch road pass through water bath and multiple organ container and with multiple organ container each groove in histoorgan artery Blood vessel is connected one by one, and described separate slot outlet is connected with outlet conduit, and the outlet conduit passes through water bath and multiple organ Container is simultaneously connected with the outlet header of an outlet for being connected with outlet flow control valves, filter and peristaltic pump in turn, The filtrate (liquid of the filter is less than the liquid level in multiple organ container;
At least 3 have graduated organ secretion container, and for collecting organ secretion, each organ container is respectively by wearing Cross the organ that the secretion outlet conduit of water bath is connected in each separate slot of the multiple organ container to be secreted in conduit accordingly;
One touch display screen, described touch display screen are connected with controller, by described touch display screen output control Signal to controller and read, the signal of display controller output, described controller and peristaltic pump, inlet flow control valve, Outlet flow control valves and temperature sensor are respectively connected with, and described controller reads the signal of temperature sensor and basis should Temperature signal output temperature control signal feeds water bath cabinet to heat to the water in water bath, and described controller reads import The signal of flow control valve and outlet flow control valves, then exports rotation control signal to peristaltic pump.
2. multiple organ save set according to claim 1, it is characterised in that:Described go-cart includes being arranged on go-cart bottom Upper mounting plate on plate, is fixed with handlebar on the left of described upper mounting plate, and four wheels are connected with described go-cart base plate, Central dividing plate and right side partition, multiple medicine pushers and oxygen cylinder peace are separately installed with right side in the middle of described upper mounting plate It is mounted on the upper mounting plate on the right side of described right side partition, described oxygen cylinder is fixed on right side by oxygen cylinder fixing band and connects dividing plate On, described peristaltic pump, oxygenation device and filter between described central dividing plate and right side partition before and after set gradually, institute The peristaltic pump stated is fixed on upper mounting plate and clamps restriction by central dividing plate and right side partition and rocks, and described oxygenation device hangs Hang and be fixedly connected on the oxygenation device connecting plate of a U-shaped, the U-shaped two ends of oxygenation device connecting plate are separately fixed at middle interval On plate and right side partition, described filter is fixedly connected on central dividing plate by filter mounting, described inlet flow Control valve is fixedly mounted on the top surface of described central dividing plate, and described water bath is fixedly mounted on the left of central dividing plate On upper mounting plate, described organ secretion container is arranged on the upper mounting plate on front side of multiple organ container, described touch display screen It is fixed on rear side of upper mounting plate by touch display screen connecting bracket.
3. the multiple organ save set according to claims 1 or 2, it is characterised in that:Described inlet flow control valve Mechanical type manual valve is adopted with outlet flow control valves.
4. the multiple organ save set according to claims 1 or 2, it is characterised in that:Described inlet flow control valve Electric control valve is adopted with outlet flow control valves.
CN201610973638.2A 2016-10-28 2016-10-28 Multi-organ preservation device Pending CN106508890A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201610973638.2A CN106508890A (en) 2016-10-28 2016-10-28 Multi-organ preservation device
DE212017000016.3U DE212017000016U1 (en) 2016-10-28 2017-01-26 A multi-organ storage device
JP2018600005U JP3223817U (en) 2016-10-28 2017-01-26 Multi-organ storage device
AU2017101824A AU2017101824A4 (en) 2016-10-28 2017-01-26 Multi-Organ Preservation Appliance
PCT/CN2017/072740 WO2018076567A1 (en) 2016-10-28 2017-01-26 Multi-organ preservation apparatus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610973638.2A CN106508890A (en) 2016-10-28 2016-10-28 Multi-organ preservation device

Publications (1)

Publication Number Publication Date
CN106508890A true CN106508890A (en) 2017-03-22

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CN201610973638.2A Pending CN106508890A (en) 2016-10-28 2016-10-28 Multi-organ preservation device

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JP (1) JP3223817U (en)
CN (1) CN106508890A (en)
AU (1) AU2017101824A4 (en)
WO (1) WO2018076567A1 (en)

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CN107156109A (en) * 2017-05-31 2017-09-15 上海市杨浦区市东医院 A kind of isolated organ preserves system
CN108157352A (en) * 2018-02-11 2018-06-15 广东顺德工业设计研究院(广东顺德创新设计研究院) Multiple organ one perfusion equipment
CN110432260A (en) * 2019-03-22 2019-11-12 天一阁医疗科技(广州)有限公司 A kind of machine perfusion save set of organism organ
CN112006016A (en) * 2019-05-31 2020-12-01 西安赛德欧医疗研究院有限公司 Normal temperature oxygenation perfusion apparatus
US20230067043A1 (en) * 2021-08-25 2023-03-02 The First Affiliated Hospital, Sun Yat-Sen University Multi-organ repairing and transferring device without interrupting blood flow

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CN1985170A (en) * 2004-02-02 2007-06-20 器官恢复系统公司 Apparatus and method for determining effects of a substance on an organ
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107156109A (en) * 2017-05-31 2017-09-15 上海市杨浦区市东医院 A kind of isolated organ preserves system
CN108157352A (en) * 2018-02-11 2018-06-15 广东顺德工业设计研究院(广东顺德创新设计研究院) Multiple organ one perfusion equipment
CN110432260A (en) * 2019-03-22 2019-11-12 天一阁医疗科技(广州)有限公司 A kind of machine perfusion save set of organism organ
CN112006016A (en) * 2019-05-31 2020-12-01 西安赛德欧医疗研究院有限公司 Normal temperature oxygenation perfusion apparatus
US20230067043A1 (en) * 2021-08-25 2023-03-02 The First Affiliated Hospital, Sun Yat-Sen University Multi-organ repairing and transferring device without interrupting blood flow
US11617364B2 (en) * 2021-08-25 2023-04-04 The First Affiliated Hospital, Sun Yat-Sen University Multi-organ repairing and transferring device without interrupting blood flow

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JP3223817U (en) 2019-11-07
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