CN206603121U - A kind of isolated organ In vitro perfusion save set - Google Patents
A kind of isolated organ In vitro perfusion save set Download PDFInfo
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- CN206603121U CN206603121U CN201720144469.1U CN201720144469U CN206603121U CN 206603121 U CN206603121 U CN 206603121U CN 201720144469 U CN201720144469 U CN 201720144469U CN 206603121 U CN206603121 U CN 206603121U
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Abstract
The utility model is related to a kind of isolated organ In vitro perfusion save set, including device box, includes organ container cabin, flooding of tank, equipment compartment and waste liquid cabin；Organ is set in organ container cabin and preserves groove and organ temperature control device, organ is preserved sets up perfusion inlet and bypass outlet separately on groove；Some perfusate containers are set in flooding of tank different type perfusion liquid is provided, the perfusion inlet that organ preserves groove can be connected to via control valve, provided with pressure monitoring, bubble monitoring and pH value monitoring device on perfusion pipeline；The bypass outlet that organ preserves groove is connected to perfusion liquid pipeline by return line, and pressure monitoring device, control valve and filter are provided with return line.Organ In vitro perfusion save set of the present utility model, can be by the oxygen and nutrient needed for providing metabolism for isolated organ, metabolite is removed, and by metaboilic level during the preservation of procedural temperature adjustment organ, so as to be reached for the purpose that isolated organ provides optimal storage in vitro environment.
Description
Technical field
The present invention relates to technical field of medical instruments, and in particular to a kind of isolated organ In vitro perfusion save set.
Background technology
With the development and the appearance of neotype immunosuppressant of surgical technic, the survival rate of organ transplant is greatly improved, etc.
The patient populations of transplanting to be subjected increase year by year, the use of substantial amounts of DCD donor organs and marginal donor organ, promote organ to protect
Technology constantly improve is deposited, also preserving relevant device to organ proposes new challenge.Isolated organ to be transplanted is transported in long-time
Afterwards, tend not to preferably be preserved, in order to preferably use longer-distance transplantation donor, extension donor organ is protected in vitro
The time is deposited, new challenge is proposed, it is necessary to develop new donor organ storage in vitro system pair to the storage in vitro of transplantation donor
Isolated organ is preserved and accordingly supported.
The content of the invention
It is an object of the invention to provide a kind of isolated organ In vitro perfusion save set, metabolism institute can be provided for isolated organ
The oxygen and nutrient needed, and remove metabolite and provide the optimal of storage in vitro there is provided procedural temperature control for isolated organ
Microenvironment.
To solve above-mentioned technical problem, the technical scheme that the present invention is provided is：
A kind of isolated organ In vitro perfusion save set, including device box, are respectively equipped with organ appearance in device box
Device cabin, flooding of tank, equipment compartment and waste liquid cabin；In the organ container cabin groove and isolated organ temperature are preserved provided with isolated organ
Device is controlled, the isolated organ preserves groove and is provided with perfusion inlet and bypass outlet；Filled in the flooding of tank provided with some
Reservoir container, each perfusate container outlet is connected to after the first control valve is connected to the isolated organ guarantor by irrigating liquid pipeline
The perfusion inlet of groove is deposited, pressure monitoring device, bubble monitoring device and pH value monitoring device are provided with the perfusion liquid pipeline；
The bypass outlet that the isolated organ preserves groove is connected to perfusion liquid pipeline by return line, is provided with the return line
Pressure monitoring device, the 3rd control valve and filter；Central control system and power system, the middle control system are provided with the equipment compartment
Unite and analyze and process the data that remaining each nacelle is returned, and connect display screen and show each research and application value, the power system includes
Self-contained battery system and external power interface.
Further, the perfusion liquid pipeline includes main priming line and first branch's priming line, the perfusion of the second branch
Pipeline, the main priming line connects first branch's priming line and second branch's priming line respectively by the second control valve,
First branch priming line is connected to the first perfusion inlet that isolated organ preserves groove, and second branch priming line connects
Connect the second perfusion inlet.
The main priming line is provided with perfusion liquid temperature control device and the first centrifugal pump, first branch priming line
Provided with oxygenator, occlusion pump, first pressure monitoring device and partial pressure of oxygen monitoring device, second branch priming line is provided with
Second centrifugal pump and second pressure monitoring device.
It is preferred that, bubble removal device is provided with the main priming line before bubble monitoring device.
Further, the first perfusate container, the second perfusate container, first perfusion are included in the flooding of tank
That distinguishes on liquid container and the second perfusate container is provided with perfusion liquid import.
Further, secretion collecting chamber is additionally provided with device box, the isolated organ preserves groove provided with secretion
Thing is exported, and the secretion outlet is connected to the secretion collection vessel in secretion collecting chamber, the secretion collection vessel
Connect corresponding secretion monitoring device.
Waste liquid cabin is connected by the 3rd control valve on the return line.
The isolated organ temperature control device and perfusion liquid temperature control device are adjustably controlled temperature between 4 DEG C -38 DEG C, are used for
Low temperature, subnormal temperature or normal temperature perfusion.
The advantage of apparatus of the present invention includes：
1. provided with cabins such as organ container cabin, flooding of tank, equipment compartment, secretion collecting chamber, waste liquid cabins in device box
Body, the control environment of storage in vitro is provided for isolated organ, and device box is portable, may be adapted to aircraft shipping.
2. controlling isolated organ filling temperature by temperature control device, visited on perfusion path provided with pH value and partial pressure of oxygen detection
First-class monitoring device, for monitoring corresponding data in real time.
3. priming line has first branch's priming line and second branch's priming line, centrifugal pump can be used to provide non-fight
Dynamic perfusion power, provides pulsatile perfusion power, it is adaptable to the need for different isolated organs using occlusion pump.
4. having different perfusion paths in flooding of tank, different perfusion liquid compositions can be respectively connected to, adjustment organ is filled
Note environment.
5. being provided with multiple control valves and pressure monitoring device in perfusion channel, it is easy to regulation perfusion composition, speed and pressure
Power.
Brief description of the drawings
Fig. 1：The structural representation of the isolated organ In vitro perfusion save set of the present invention.
Embodiment
With reference to specific embodiment, the invention will be further described.
A kind of isolated organ In vitro perfusion save set, including device box, are respectively equipped with organ appearance in device box
Device cabin, flooding of tank, equipment compartment and waste liquid cabin.
Groove and isolated organ temperature control device are preserved provided with isolated organ in the organ container cabin, the isolated organ is protected
Groove is deposited provided with perfusion inlet and bypass outlet；Some perfusate containers, each perfusate container are provided with the flooding of tank
Outlet is connected to after the first control valve is connected to the perfusion inlet that the isolated organ preserves groove by irrigating liquid pipeline, described
Irrigate liquid pipeline and be provided with pressure monitoring device, bubble monitoring device and pH value monitoring device；The isolated organ preserves groove
Bypass outlet is connected to perfusion liquid pipeline by return line, provided with the 3rd pressure monitoring device, the on the return line
Three control valves.
Filter is additionally provided with the return line, perfusion liquid can be effectively removed big via the diameter produced after organ perfusion
In 200um sludged blood, impurity and foreign matter etc..Waste liquid cabin is connected by the 3rd control valve on the return line.
Central control system and power system are provided with the equipment compartment, the central control system analyzes and processes remaining each monitoring device
Data are handled by the data of return, can be according to the change of monitor value, the ginseng such as adjust automatically perfusion composition, temperature, speed
Number, connection display screen shows each research and application value, and the power system includes self-contained battery system and external power interface, described
Central control system is central processing unit control system.
The perfusion liquid pipeline includes main priming line and first branch's priming line, second branch's priming line, described
Main priming line connects first branch's priming line and second branch's priming line, described first point respectively by the second control valve
Branch priming line is connected to the first perfusion inlet that isolated organ preserves groove, and second branch priming line connection second is irrigated
Entrance.
First control valve, the second control valve, the 3rd control valve are connected with central control system signal.Perfusion system is to difference
Perfusion path gives different injection pressures, can be monitored by the pressure monitoring device on perfusion path, and feeds back to control system
System, can be irrigated the regulation of flow, to reach the purpose precisely irrigated for pressure change by control valve.
The main priming line is provided with perfusion liquid temperature control device and the first centrifugal pump, first branch priming line
Provided with oxygenator, occlusion pump, first pressure monitoring device and partial pressure of oxygen monitoring device, hollow fiber bundle oxygenator conduct can be used
Oxygen syzygy is united, and the perfusion liquid after being closed through oxygen can be irrigated to the isolated organ in organ container cabin.
Second branch priming line is provided with the second centrifugal pump and second pressure monitoring device.Liang Tiao branches intrusion pipe
Road provides non pulsatile perfusion power using centrifugal pump respectively and provides pulsatile perfusion power using occlusion pump.Perfusion system is to difference
Perfusion path gives different injection pressures, can be monitored by the pressoreceptor on perfusion path, and feeds back to control system,
The regulation of flow is irrigated for pressure change, to reach the purpose precisely irrigated.
Bubble removal device is provided with the main priming line before bubble monitoring device.There is perfusion system bubble to go
Except device and bubble monitoring device, bubble monitoring device can measure perfusion path in fluid flow velocity and determine whether fluid is deposited
In bubble, bubble removal device can remove the bubble that device is flowed through in priming line.
Include the first perfusate container, the second perfusate container in the flooding of tank, first perfusate container and
That distinguishes in the second perfusate container is provided with perfusion liquid import.Different perfusion paths in flooding of tank can be respectively connected to not
With perfusion liquid composition.
It is preferred that, secretion collecting chamber is additionally provided with device box, the isolated organ preserves groove and is provided with secretion
Outlet, the secretion outlet is connected to the secretion collection vessel in secretion collecting chamber, and the secretion collection vessel connects
Connect corresponding secretion monitoring device.Secretion is exported by secretion pipe-line system, is collected in container, is according to secretion
The difference of bile or urine etc., secretion container can connect the corresponding secretion monitoring device of setting, secretion object amount be carried out real
When monitoring analysis.
The isolated organ temperature control device and perfusion liquid temperature control device can use temperature detection and regulation device in this area,
Temperature adjustment controls setting range between 4 DEG C -38 DEG C, for the perfusion of low temperature, subnormal temperature or normal temperature.The isolated organ temperature
Control device and perfusion liquid temperature control device are connected with central control system signal, and its temperature control work operation is regulated and controled by central control system.
The power system includes external power source interface, and external power supply or vehicle-mounted can be used when there is available external power supply
Power supply is powered, and is transformed into external power supply unpowered and is used self-contained battery system power supply.Described device casing is carried without line number
, can be by each monitoring and controlling data exporting according to output function.
It is described above, only it is presently preferred embodiments of the present invention, any formal limitation not is made to the present invention, it is any ripe
Professional and technical personnel is known, it is without departing from the scope of the present invention, real to more than according to the technical spirit of the present invention
Apply any simple modification, equivalent substitution that example made and improve etc., still fall within technical solution of the present invention protection domain it
It is interior.
Claims (9)
1. a kind of isolated organ In vitro perfusion save set, it is characterised in that：Including device box, set respectively in device box
There are organ container cabin, flooding of tank, equipment compartment and waste liquid cabin；In the organ container cabin provided with isolated organ preserve groove and from
Body organ temperature control device, the isolated organ preserves groove and is provided with perfusion inlet and bypass outlet；Set in the flooding of tank
Have some perfusate containers, each perfusate container outlet be connected to after the first control valve by irrigate liquid pipeline be connected to it is described from
Body organ preserves the perfusion inlet of groove, provided with pressure monitoring device, bubble monitoring device and pH prisons on the perfusion liquid pipeline
Survey device；The bypass outlet that the isolated organ preserves groove is connected to perfusion liquid pipeline by return line, in the return duct
Road is provided with pressure monitoring device, the 3rd control valve and filter；Central control system and power system, institute are provided with the equipment compartment
State central control system and analyze and process the data that remaining each monitoring device is returned, and connect display screen and show each research and application value, it is described
Power system includes self-contained battery system and external power interface.
2. isolated organ In vitro perfusion save set according to claim 1, it is characterised in that：The perfusion liquid pipeline bag
Main priming line and first branch's priming line, second branch's priming line are included, the main priming line passes through the second control valve
First branch's priming line and second branch's priming line are connected respectively, and first branch priming line is connected to isolated organ
The first perfusion inlet of groove is preserved, second branch priming line connects the second perfusion inlet.
3. isolated organ In vitro perfusion save set according to claim 2, it is characterised in that：On the main priming line
Provided with perfusion liquid temperature control device and the first centrifugal pump, first branch priming line is provided with oxygenator, occlusion pump, the first pressure
Power monitoring device and partial pressure of oxygen monitoring device, second branch priming line are monitored provided with the second centrifugal pump and second pressure
Device.
4. isolated organ In vitro perfusion save set according to claim 2, it is characterised in that：On the main priming line
Bubble removal device is provided with before bubble monitoring device.
5. isolated organ In vitro perfusion save set according to claim 1, it is characterised in that：Wrapped in the flooding of tank
Include in the first perfusate container, the second perfusate container, first perfusate container and the second perfusate container setting respectively
There is perfusion liquid import.
6. isolated organ In vitro perfusion save set according to claim 1, it is characterised in that：Also set in device box
There is secretion collecting chamber, the isolated organ preserves groove and exported provided with secretion, the secretion outlet is connected to secretion
Secretion collection vessel in collecting chamber, the secretion collection vessel connects corresponding secretion monitoring device.
7. isolated organ In vitro perfusion save set according to claim 1, it is characterised in that：Lead on the return line
Cross the 3rd control valve connection waste liquid cabin.
8. isolated organ In vitro perfusion save set according to claim 3, it is characterised in that：The isolated organ temperature control
Device and perfusion liquid temperature control device intelligent control temperature are between 4 DEG C -38 DEG C, for the perfusion of low temperature, subnormal temperature or normal temperature.
9. isolated organ In vitro perfusion save set according to claim 1, it is characterised in that：The power system includes
External power source interface, can use external power supply or vehicle power to power, in external power supply without confession when there is available external power supply
It is transformed into when electric and uses self-contained battery system power supply.
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| CN201720144469.1U CN206603121U (en) | 2017-02-17 | 2017-02-17 | A kind of isolated organ In vitro perfusion save set |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106689119A (en) * | 2017-02-17 | 2017-05-24 | 南京鼓楼医院 | Isolated organ in vitro perfusion preservation device |
| CN108913592A (en) * | 2018-07-09 | 2018-11-30 | 上海天引生物科技有限公司 | A kind of organ storage in vitro and culture apparatus and its method |
| CN109511649A (en) * | 2018-11-21 | 2019-03-26 | 嘉兴莱普晟医疗科技有限公司 | A kind of room temperature machine perfusion system that can expand for liver source |
| CN110506733A (en) * | 2019-08-26 | 2019-11-29 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Isolated organ perfusion container |
| CN110558310A (en) * | 2019-08-26 | 2019-12-13 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | isolated organ perfusion liquid-changing system |
| CN110692623A (en) * | 2019-08-26 | 2020-01-17 | 陈静瑜 | Isolated organ perfusion filtration system |
| CN111657262A (en) * | 2019-12-22 | 2020-09-15 | 西安定华电子股份有限公司 | Organ preservation device and organ preservation method |
-
2017
- 2017-02-17 CN CN201720144469.1U patent/CN206603121U/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106689119A (en) * | 2017-02-17 | 2017-05-24 | 南京鼓楼医院 | Isolated organ in vitro perfusion preservation device |
| CN108913592A (en) * | 2018-07-09 | 2018-11-30 | 上海天引生物科技有限公司 | A kind of organ storage in vitro and culture apparatus and its method |
| CN109511649A (en) * | 2018-11-21 | 2019-03-26 | 嘉兴莱普晟医疗科技有限公司 | A kind of room temperature machine perfusion system that can expand for liver source |
| CN109511649B (en) * | 2018-11-21 | 2021-06-25 | 嘉兴莱普晟医疗科技有限公司 | Normal-temperature mechanical perfusion system capable of expanding liver supply source |
| CN110506733A (en) * | 2019-08-26 | 2019-11-29 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Isolated organ perfusion container |
| CN110558310A (en) * | 2019-08-26 | 2019-12-13 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | isolated organ perfusion liquid-changing system |
| CN110692623A (en) * | 2019-08-26 | 2020-01-17 | 陈静瑜 | Isolated organ perfusion filtration system |
| CN111657262A (en) * | 2019-12-22 | 2020-09-15 | 西安定华电子股份有限公司 | Organ preservation device and organ preservation method |
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