CN110506733A - Isolated organ perfusion container - Google Patents
Isolated organ perfusion container Download PDFInfo
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- CN110506733A CN110506733A CN201910790498.9A CN201910790498A CN110506733A CN 110506733 A CN110506733 A CN 110506733A CN 201910790498 A CN201910790498 A CN 201910790498A CN 110506733 A CN110506733 A CN 110506733A
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- isolated organ
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- 210000000056 organ Anatomy 0.000 title claims abstract description 97
- 230000010412 perfusion Effects 0.000 title claims abstract description 89
- 239000007788 liquid Substances 0.000 claims abstract description 128
- 239000012528 membrane Substances 0.000 claims abstract description 25
- 239000013589 supplement Substances 0.000 claims description 16
- 210000001367 artery Anatomy 0.000 claims description 15
- 239000000565 sealant Substances 0.000 claims description 15
- 239000002699 waste material Substances 0.000 claims description 15
- 230000002572 peristaltic effect Effects 0.000 claims description 14
- 238000010586 diagram Methods 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 238000004321 preservation Methods 0.000 description 5
- 239000008246 gaseous mixture Substances 0.000 description 4
- 230000008676 import Effects 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 208000028867 ischemia Diseases 0.000 description 3
- 206010037423 Pulmonary oedema Diseases 0.000 description 2
- 230000002612 cardiopulmonary effect Effects 0.000 description 2
- 238000005429 filling process Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 229920001917 Ficoll Polymers 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000001951 hemoperfusion Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000012533 medium component Substances 0.000 description 1
- 230000034217 membrane fusion Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- DKJCUVXSBOMWAV-PCWWUVHHSA-N naltrindole Chemical compound N1([C@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CC2=C3[CH]C=CC=C3N=C25)O)CC1)O)CC1CC1 DKJCUVXSBOMWAV-PCWWUVHHSA-N 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of isolated organ perfusion containers, the isolated organ perfusion container includes: cover, pallet, support membrane and power pump head, the pallet and the support membrane are set in the cover, the support membrane is fixed on the pallet to support isolated organ, the bottom of the pallet is equipped with the reservoir for accommodating perfusion liquid, the reservoir is equipped with the first liquid outlet, the through-hole for being connected to the reservoir is opened up on the support membrane, the power pump head with the output end of kinetic pump for connecting, the power pump head, which is equipped with, goes out liquid interface for first with the first feed liquor interface of the first liquid outlet pipeline connection and for being connected to the arterial line of the isolated organ, above-mentioned isolated organ perfusion container can realize that the long-time of isolated organ saves under normal temperature environment, promote the success rate of transfer operation.
Description
Technical field
The present invention relates to medical assistance equipment technology fields, more particularly to a kind of isolated organ perfusion container.
Background technique
When carrying out organ transplant, the preservation of organ can directly determine the success or failure of transfer operation.
Currently, the method that low temperature static preservation is usually used carries out the preservation of isolated organ, i.e., device is reduced by low temperature
Function consumption, the holding time of Lai Yanchang organ.
But prolonged low temperature environment, histocyte can be caused to be damaged on isolated organ, organ ischemia etc. asks
Topic, to reduce the success rate of transfer operation.
Summary of the invention
Based on this, it is necessary in view of the above technical problems, a kind of isolated organ perfusion container is provided, by by isolated organ
It is placed in perfusion container, and continues that perfusion liquid is perfused to isolated organ, to realize the long-time of isolated organ under normal temperature environment
Save, so effectively such as histocyte brought by low temperature environment is avoided to be damaged, organ ischemia the problems such as, promoted transplant
The success rate of operation.
To achieve the above object, the present invention provides a kind of isolated organ perfusion container, the isolated organ perfusion container
It include: cover, pallet, support membrane and power pump head, the pallet and the support membrane are set in the cover, the support membrane
It being fixed on the pallet to support isolated organ, the bottom of the pallet is equipped with the reservoir for accommodating perfusion liquid,
The reservoir is equipped with the first liquid outlet, and the through-hole for being connected to the reservoir, the power are opened up on the support membrane
Pump head with the output end of kinetic pump for connect, and the power pump head is equipped with for the with the first liquid outlet pipeline connection
One feed liquor interface and for being connected to the arterial line of the isolated organ first go out liquid interface.
Above-mentioned isolated organ perfusion container compared with the background art, at least has the advantages that in vitro device first
Official is placed on support membrane, and perfusion liquid is injected in reservoir, and the first feed liquor interface of power pump head is then passed through pipeline
It is connected to the first liquid outlet of reservoir, goes out liquid interface for the first of power pump head and connected by the artery of pipeline and isolated organ
It is logical, start kinetic pump later, kinetic pump driving perfusion liquid flows in pipeline, and perfusion liquid is flowed out from the first liquid outlet of reservoir
Afterwards, go out liquid interface and artery followed by the first feed liquor interface, first, finally discharged from isolated organ, and through support membrane
Through-hole be back in reservoir, so realize that perfusion liquid circulates, continue to be perfused to isolated organ to realize
Liquid to realize that the long-time of isolated organ saves under normal temperature environment, and then effectively avoids such as group brought by low temperature environment
Knit cell be damaged, organ ischemia the problems such as；Meanwhile driving perfusion liquid to circulate by kinetic pump, it can effectively remove
Thrombus, inflammatory factor or other foreign matter harmful substances in isolated organ, and then the function vascular patency of isolated organ can be maintained,
So as to improve pulmonary edema, raising cardiopulmonary oxygen conjunction ability etc., and art can be reduced to carry out repairing and treating to isolated organ
Graft loses the risk of function afterwards, effectively promotes the utilization rate of donor organ and the success rate of transfer operation.
It in one embodiment, further include being gone out between liquid interface and the artery by piping connection in described first
Oxygenator, the oxygenator are equipped with the gaseous mixture interface for being connected to mixing gas source pipe road.
In one embodiment, the oxygenator is connected to form circulating heat exchanging pipe with heat-exchanger rig by pipeline, institute
It states perfusion liquid and carries out heat exchange with the heat exchange liquid in the oxygenator.
It in one embodiment, further include leucocyte filter, the leucocyte filter is by piping connection in institute
It states between oxygenator and the artery.
It in one embodiment, further include Micro- Bolt Filter, the Micro- Bolt Filter is by piping connection in the oxygen
Between clutch and the artery or between the power pump head and the oxygenator.
It in one embodiment, further include waste liquid tank and sealant supplement cylinder, the reservoir is additionally provided with the second liquid outlet, described
Waste liquid tank and the second liquid outlet pipeline connection, the pipeline between the waste liquid tank and second liquid outlet, which is equipped with, to be used for
The second peristaltic pump for flowing into the power of the waste liquid tank, the benefit are provided to the perfusion liquid flowed out from second liquid outlet
Flow container and the reservoir pipeline connection, the pipeline between the sealant supplement cylinder and the reservoir are equipped with for from the benefit
The perfusion liquid of flow container outflow provides the third peristaltic pump for flowing into the power of the reservoir.
It in one embodiment, further include dialyzer, the dialyzer is by pipeline connection in second liquid outlet
Between the sealant supplement cylinder, second peristaltic pump is also used to provide stream to the perfusion liquid flowed out from second liquid outlet
Power through the dialyzer.
In one embodiment, the support membrane is recessed to close to the reservoir direction.
In one embodiment, the output end of the power pump head and the kinetic pump is detachably connected.
In one embodiment, the pallet is equipped with pipeline support, and the pipeline support is equipped with multiple for solid
Determine the bayonet of pipeline.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of isolated organ perfusion container described in one embodiment of the invention；
Fig. 2 is the schematic diagram of internal structure of isolated organ perfusion container shown in Fig. 1；
Fig. 3 is the structural schematic diagram of the pallet in isolated organ perfusion container shown in Fig. 2；
Fig. 4 is the structural schematic diagram of the power pump head in isolated organ perfusion container shown in Fig. 1；
Fig. 5 is the partial sectional view of isolated organ perfusion container shown in Fig. 1；
Fig. 6 is the structural schematic diagram of the oxygenator in isolated organ perfusion container shown in Fig. 2；
Fig. 7 is the structural schematic diagram of the leucocyte filter in isolated organ perfusion container shown in Fig. 2；
Fig. 8 is the structural schematic diagram of the Micro- Bolt Filter in isolated organ perfusion container shown in Fig. 2；
Fig. 9 is the attachment structure schematic diagram of isolated organ perfusion container shown in Fig. 1.
10, cover, 20, pallet, 21, support membrane, 211, through-hole, 22, reservoir, the 221, first liquid outlet, 222, second
Liquid outlet, 23, pipeline support, 30, power pump head, the 31, first feed liquor interface, 32, first go out liquid interface, 40, oxygenator, 41,
Second feed liquor interface, 42, second goes out liquid interface, 43, gaseous mixture interface, 44, heat exchange import, 45, heat exchange outlet, 50, leucocyte
Filter, 51, third feed liquor interface, 52, third go out liquid interface, 60, Micro- Bolt Filter, the 61, the 4th feed liquor interface, the 62, the 4th
Liquid interface out, 70, waste liquid tank, the 71, second peristaltic pump, 80, sealant supplement cylinder, 81, third peristaltic pump, 90, dialyzer.
Specific embodiment
To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing
Give better embodiment of the invention.But the invention can be realized in many different forms, however it is not limited to herein
Described embodiment.On the contrary, the purpose of providing these embodiments is that making to understand more the disclosure
Add thorough and comprehensive.
It should be noted that it can directly on the other element when element is referred to as " being fixed on " another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it, which can be, is directly connected to
To another element or it may be simultaneously present centering elements.On the contrary, when element is referred to as " directly existing " another element "upper",
There is no intermediary elements.Heretofore described " first ", " second ", " third ", " the 4th " do not represent specific quantity and sequence,
It is only used for the differentiation of title.
As shown in Figures 1 to 4, a kind of isolated organ perfusion container, be applicable in normal temperature environment to such as in vitro lungs,
The isolated organs such as isolated heart carry out long-time preservation, while being also applied for repairing isolated organ, which includes: cover
Body 10, pallet 20, support membrane 21 and power pump head 30, pallet 20 and support membrane 21 are set in cover 10, and the fixation of support membrane 21 is set
It sets to support isolated organ on pallet 20, the bottom of pallet 20 is equipped with the reservoir 22 for accommodating perfusion liquid, reservoir 22
Equipped with the first liquid outlet 221, open up the through-hole 211 for being connected to reservoir 22 on support membrane 21, power pump head 30 be used for
The output end connection of kinetic pump (in attached drawing not identify), power pump head 30 be equipped with for 221 pipeline connection of the first liquid outlet
The first feed liquor interface 31 and for the arterial line with isolated organ be connected to first go out liquid interface 32.
In the application, isolated organ is placed on support membrane 21 first, and injects perfusion liquid in reservoir 22, then
First feed liquor interface 31 of power pump head 30 is connected to by pipeline with the first liquid outlet 221 of reservoir 22, by power pump head
The first of 30 goes out liquid interface 32 and is connected to by pipeline with the artery of isolated organ, starts kinetic pump, kinetic pump driving perfusion later
Liquid flows in pipeline, perfusion liquid from the first liquid outlet 221 of reservoir 22 outflow after, followed by the first feed liquor interface 31,
First goes out liquid interface 32 and artery, finally discharges from isolated organ, and be back to reservoir through the through-hole of support membrane 21 211
In 22, circulating for perfusion liquid is so realized, to realize continue that perfusion liquid is perfused to isolated organ, under normal temperature environment
It realizes that the long-time of isolated organ saves, and then effectively such as histocyte brought by low temperature environment is avoided to be damaged, device
The problems such as official's ischemic；Meanwhile drive perfusion liquid to circulate by kinetic pump, can effectively remove thrombus in isolated organ,
Inflammatory factor or other foreign matter harmful substances, and then the function vascular patency of isolated organ can be maintained, so as to improve such as lung
Oedema, raising cardiopulmonary oxygen conjunction ability etc., and the wind that postoperative graft loses function can be reduced to carry out repairing and treating to isolated organ
Danger effectively promotes the utilization rate of donor organ and the success rate of transfer operation.
Specifically, incorporated by reference to Fig. 2, through-hole 211 has multiple, and multiple through-holes 211 are evenly distributed on support membrane 21.
Specifically, perfusion liquid is mixed by DMEM/F12 medium component, albumin and 70 ratio of ficoll.
In one embodiment, incorporated by reference to Fig. 2 and Fig. 6, above-mentioned isolated organ perfusion container further include by piping connection in
First goes out oxygenator 40 between liquid interface 32 and artery, oxygenator 40 be equipped with for mix gas source and (do not show in attached drawing
The gaseous mixture interface 43 of pipeline connection out).Power pump head 30, oxygenator 40, isolated organ and reservoir 22 are connected to formation circulation
Priming line, perfusion liquid form oxygen in conjunction with gaseous mixture in oxygenator 40 and close perfusion liquid, to guarantee to flow into the perfusion liquid of artery
Oxygen content it is sufficient.
In one embodiment, oxygenator 40 is connected to form circulating picture-changing by pipeline with heat-exchanger rig (not showing that in attached drawing)
Pipe line, perfusion liquid carry out heat exchange with heat exchange liquid in oxygenator 40.Power pump head 30, oxygenator 40, isolated organ and storage
The connection of liquid bath 22 forms circumfusion pipeline, and perfusion liquid carries out heat exchange with heat exchange liquid in oxygenator 40, to keep perfusion liquid
Temperature be mutually suitable for isolated organ.
Specifically, incorporated by reference to Fig. 2, Fig. 6 and Fig. 9, oxygenator 40 be equipped with the second feed liquor interface 41, second go out liquid interface 42,
Exchange heat import 44 and heat exchange outlet 45, the first feed liquor interface 31, dynamic of the first liquid outlet 221 of reservoir 22, power pump head 30
The first of power pump head 30 goes out liquid interface 32, the second feed liquor interface 41, second goes out liquid interface 42 and the artery of isolated organ is successively managed
Road is connected to form above-mentioned circumfusion pipeline, the outlet of heat exchange liquid, heat exchange import 44, heat exchange outlet 45 and the heat exchange dress of heat-exchanger rig
Successively pipeline connection forms above-mentioned circulating heat exchanging pipe for the heat exchange liquid import set.
In one embodiment, incorporated by reference to Fig. 2, above-mentioned isolated organ perfusion container further includes leucocyte filter 50, white thin
Born of the same parents' filter 50 is by piping connection between oxygenator 40 and artery.Perfusion liquid enters leucocyte mistake after the outflow of oxygenator 40
Leukoreduction filter is carried out in filter 50, effectively reduces the damage that isolated organ occurs because being irrigated perfusion, while can have
Effect delays organ naltrindole to occur, and further promotes the utilization rate of donor organ and the success rate of transfer operation.
Specifically, incorporated by reference to Fig. 7 and Fig. 9, leucocyte filter 50 is equipped with third feed liquor interface 51 and third goes out liquid interface
52, third feed liquor interface 51 and second goes out 42 pipeline connection of liquid interface, and third goes out the arterial line of liquid interface 52 Yu isolated organ
Connection.
In one embodiment, incorporated by reference to Fig. 2, above-mentioned isolated organ perfusion container further includes Micro- Bolt Filter 60, micro- bolt mistake
Filter 60 is by piping connection between oxygenator 40 and artery or power pump head 30 and oxygenator 40.Perfusion liquid is from oxygenator 40
Enter in Micro- Bolt Filter 60 after outflow, Micro- Bolt Filter 60 is used to filter out various micro- bolts in perfusion liquid, prevent because of thrombus or
Various micro- bolts such as aeroembolism and the embolism of the capilary that causes isolated organ, effectively improve the hemoperfusion of human microvascular, into
One step promotes the utilization rate of donor organ and the success rate of transfer operation.
Specifically, incorporated by reference to Fig. 8 and Fig. 9, Micro- Bolt Filter 60 is equipped with the 4th feed liquor interface 61 and the 4th and goes out liquid interface 62,
4th feed liquor interface 61 and second goes out 42 pipeline connection of liquid interface, and the 4th goes out the arterial line company of liquid interface 62 and isolated organ
It is logical.
Further, incorporated by reference to Fig. 2, aforementioned two embodiment is combined, by leucocyte filter 50 and Micro- Bolt Filter 60
It is connected between oxygenator 40 and isolated organ simultaneously, wherein the connection between leucocyte filter 50 and Micro- Bolt Filter 60
Sequencing is unlimited, further the utilization rate of promotion isolated organ and the success rate of transfer operation.
In one embodiment, incorporated by reference to Fig. 5 and Fig. 9, above-mentioned isolated organ perfusion container further includes waste liquid tank 70 and fluid infusion
Tank 80, reservoir 22 are additionally provided with the second liquid outlet 222,222 pipeline connection of waste liquid tank 70 and the second liquid outlet, waste liquid tank 70 and
Pipeline between two liquid outlets 222, which is equipped with, flows into waste liquid tank 70 for providing to the perfusion liquid flowed out from the second liquid outlet 222
Power the second peristaltic pump 71, sealant supplement cylinder 80 and 22 pipeline connection of reservoir, the pipeline between sealant supplement cylinder 80 and reservoir 22
It is equipped with for providing the third peristaltic pump 81 for flowing into the power of reservoir 22 to the perfusion liquid flowed out from sealant supplement cylinder 80.Through multiple
Perfusion liquid after circulation is flowed out from the second liquid outlet 222 of reservoir 22, flows into waste liquid tank under the driving of the second peristaltic pump 71
In 70, meanwhile, the new perfusion liquid in sealant supplement cylinder 80 flows into reservoir 22 under the driving of third peristaltic pump 81, realizes perfusion liquid
Supplement displacement, to guarantee the perfusion liquid capacity constant in reservoir 22.
In one embodiment, incorporated by reference to Fig. 9, above-mentioned isolated organ perfusion container further includes dialyzer 90, and dialyzer 90 is logical
Pipeline connection is crossed between the second liquid outlet 222 and sealant supplement cylinder 80, the second peristaltic pump 71 is also used to flow to from the second liquid outlet 222
Perfusion liquid out provides the power for flowing through dialyzer 90.The perfusion liquid flowed out from the second liquid outlet 222 is in the second peristaltic pump 71
Under driving, a part is flowed into waste liquid tank 70, and another part is by the dialyzer new perfusion after 90s with from the outflow of sealant supplement cylinder 80
Liquid accumulates to be flowed into reservoir 22 all the way, is effectively reduced the loss of perfusion liquid, is saved use cost.
In one embodiment, support membrane 21 is recessed to close to 22 direction of reservoir, provides more preservations for isolated organ
Space avoids isolated organ from being oppressed in filling process and causes to damage, and particularly, support membrane 21, which can be used, has elasticity
Soft film, such as Silicon moulds further avoid isolated organ and are damaged.
In one embodiment, the output end of the power pump head 30 and the kinetic pump is detachably connected.In filling process
In, perfusion liquid is not in contact in isolated organ perfusion container internal flow with kinetic pump, can after completing perfusion operation
Power pump head 30 is split out from kinetic pump, and isolated organ perfusion container is thrown aside, is carrying out next isolated organ perfusion behaviour
When making, isolated organ perfusion container and the kinetic pump installation more renewed is connected, to realize isolated organ perfusion container
Disposable, complete machine is replaced after the completion of avoiding each isolated organ from being perfused, and use cost is effectively reduced.
In one embodiment, incorporated by reference to Fig. 2, pallet 20 is equipped with pipeline support 23, and pipeline support 23 is equipped with multiple use
In the bayonet of fixed pipeline.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of isolated organ perfusion container, which is characterized in that the isolated organ perfusion container includes: cover, pallet, branch
Film and power pump head are supportted, the pallet and the support membrane are set in the cover, and the support membrane is fixed at the support
To support isolated organ on disk, the bottom of the pallet is equipped with the reservoir for accommodating perfusion liquid, and the reservoir is equipped with the
One liquid outlet opens up the through-hole for being connected to the reservoir on the support membrane, and the power pump head is used for and kinetic pump
Output end connection, the power pump head is equipped with and for the first feed liquor interface with the first liquid outlet pipeline connection and is used for
First be connected to the arterial line of the isolated organ goes out liquid interface.
2. isolated organ perfusion container according to claim 1, which is characterized in that further include by piping connection in described
First goes out the oxygenator between liquid interface and the artery, and the oxygenator is equipped with mixed for being connected to mixing gas source pipe road
Close gas interface.
3. isolated organ perfusion container according to claim 2, which is characterized in that the oxygenator passes through pipeline and heat exchange
Device is connected to form circulating heat exchanging pipe, and the perfusion liquid carries out heat exchange with the heat exchange liquid in the oxygenator.
4. isolated organ perfusion container according to claim 2, which is characterized in that it further include leucocyte filter, it is described
Leucocyte filter is by piping connection between the oxygenator and the artery.
5. isolated organ perfusion container according to claim 2, which is characterized in that it further include Micro- Bolt Filter, it is described micro-
Bolt filter is by piping connection between the oxygenator and the artery or between the power pump head and the oxygenator.
6. isolated organ perfusion container according to claim 1, which is characterized in that further include waste liquid tank and sealant supplement cylinder, institute
State reservoir and be additionally provided with the second liquid outlet, the waste liquid tank and the second liquid outlet pipeline connection, the waste liquid tank with it is described
Pipeline between second liquid outlet is equipped with for providing described in inflow to the perfusion liquid flowed out from second liquid outlet
Second peristaltic pump of the power of waste liquid tank, the sealant supplement cylinder and the reservoir pipeline connection, the sealant supplement cylinder and the liquid storage
Pipeline between slot is equipped with for providing the power for flowing into the reservoir to the perfusion liquid flowed out from the sealant supplement cylinder
Third peristaltic pump.
7. isolated organ perfusion container according to claim 6, which is characterized in that it further include dialyzer, the dialyzer
Through pipeline connection between second liquid outlet and the sealant supplement cylinder, second peristaltic pump is also used to from described second
The perfusion liquid of liquid outlet outflow provides the power for flowing through the dialyzer.
8. isolated organ perfusion container according to claim 1-7, which is characterized in that the support membrane is to close
The reservoir direction recess.
9. isolated organ perfusion container according to claim 1-7, which is characterized in that the power pump head and institute
The output end for stating kinetic pump is detachably connected.
10. isolated organ perfusion container according to claim 1-7, which is characterized in that the pallet is equipped with
Pipeline support, the pipeline support are equipped with multiple for fixing the bayonet of pipeline.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910790498.9A CN110506733A (en) | 2019-08-26 | 2019-08-26 | Isolated organ perfusion container |
| PCT/CN2020/107631 WO2021036738A1 (en) | 2019-08-26 | 2020-08-07 | Ex vivo organ perfusion container |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910790498.9A CN110506733A (en) | 2019-08-26 | 2019-08-26 | Isolated organ perfusion container |
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| CN110506733A true CN110506733A (en) | 2019-11-29 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111727960A (en) * | 2020-07-30 | 2020-10-02 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Medical isolated organ mechanical perfusion device and power source assembly thereof |
| CN111903665A (en) * | 2020-08-17 | 2020-11-10 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Liquid storage device and isolated organ perfusion system |
| WO2021036738A1 (en) * | 2019-08-26 | 2021-03-04 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Ex vivo organ perfusion container |
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