CN109907037A - Constant-temperature perfusion formula isolated organ perfusion container - Google Patents
Constant-temperature perfusion formula isolated organ perfusion container Download PDFInfo
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- CN109907037A CN109907037A CN201910284008.8A CN201910284008A CN109907037A CN 109907037 A CN109907037 A CN 109907037A CN 201910284008 A CN201910284008 A CN 201910284008A CN 109907037 A CN109907037 A CN 109907037A
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Abstract
The present invention relates to a kind of constant-temperature perfusion formula isolated organ perfusion containers, the constant-temperature perfusion formula isolated organ perfusion container includes: fluid reservoir, the inside of the fluid reservoir is separated to form the first cavity and the second cavity, first cavity is for accommodating perfusion liquid, second cavity is for accommodating heat exchange fluid, the heat of the heat exchange fluid is transferred in the intracorporal perfusion liquid of first chamber from second cavity, above-mentioned constant-temperature perfusion formula isolated organ perfusion container can effectively keep perfusion liquid temperature, so that isolated organ be made effectively to be saved.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly to a kind of constant-temperature perfusion formula isolated organ perfusion container.
Background technique
When carrying out organ transplant, can isolated organ effectively save the success or failure that can directly determine transfer operation.
Currently, isolated organ would generally be placed in perfusion container and toward perfusion perfusion liquid in isolated organ, with reach from
The preservation of body organ and repair purpose, as the holding time increases, be accommodated in the perfusion liquid temperature in perfusion container can gradually under
Drop will cause isolated organ damage, cause isolated organ that can not reach when perfusion liquid temperature is decreased below clinical trial temperature
To transplanting standard.
Summary of the invention
Based on this, it is necessary in view of the above technical problems, a kind of constant-temperature perfusion formula isolated organ perfusion container is provided, so that
Constant-temperature perfusion formula isolated organ perfusion container can effectively keep perfusion liquid temperature, so that isolated organ be made effectively to be saved.
To achieve the above object, the present invention provides a kind of constant-temperature perfusion formula isolated organ perfusion container, and the constant temperature fills
Note formula isolated organ perfusion container includes: fluid reservoir, and the inside of the fluid reservoir is separated to form the first cavity and the second cavity, institute
The first cavity is stated for accommodating perfusion liquid, for second cavity for accommodating heat exchange fluid, the heat of the heat exchange fluid can be from
Second cavity is transferred in the intracorporal perfusion liquid of first chamber.
Above-mentioned constant-temperature perfusion formula isolated organ perfusion container compared with the background art, at least has the advantages that
First cavity and the second cavity are set in fluid reservoir, and the heat transfer of the heat exchange fluid in the second cavity is to the first cavity, with this
Perfusion liquid in first cavity is heated, effectively avoids the temperature of perfusion liquid from dropping to clinical trial temperature and causes in vitro
The case where organ damage, occurs, so that isolated organ be made effectively to be saved.
In one embodiment, second cavity is located on the periphery wall of first cavity, or, first chamber
Body is located on the periphery wall of second cavity.
It in one embodiment, further include support membrane, the fluid reservoir upper installing hole, the support membrane covering is mounted on
On the mounting hole, it is additionally provided on the fluid reservoir for by the liquid outlet of first cavity and isolated organ pipeline connection,
The support membrane is equipped with the leak hole for being connected to first cavity.
In one embodiment, the fluid reservoir is equipped with the filling opening for being connected to first cavity, described
Fluid reservoir is equipped with the leakage fluid dram for being connected to first cavity.
In one embodiment, the fluid reservoir is transparent tank body, and the side wall of the fluid reservoir is equipped with for indicating
The silk-screen portion of the capacity of the perfusion liquid.
In one embodiment, the fluid reservoir is equipped with the heat exchange import for being respectively used to be connected to second cavity
It is exported with heat exchange, the heat exchange import and heat exchange outlet form heat exchange cycle access with heating device piping connection respectively.
In one embodiment, the fluid reservoir is equipped with temperature-measuring port, is equipped in the temperature-measuring port described for detecting
The temperature detecting unit of the temperature of perfusion liquid or the heat exchange fluid.
In one embodiment, the heat exchange outlet is set to the lower part of second cavity, and the heat exchange import is set to
The top of second cavity.
In one embodiment, the bottom of the fluid reservoir is equipped with and opens for what second cavity was in communication with the outside
Mouthful, the fluid reservoir is removably equipped with the bottom cover for covering the opening.
In one embodiment, the bottom cover be equipped with sealing element, the sealing element be pressed on the bottom cover with it is described
Between the outer rim of opening.
Detailed description of the invention
Fig. 1 is the main view of constant-temperature perfusion formula isolated organ perfusion container described in one embodiment of the invention；
Fig. 2 is the sectional view along A-A of constant-temperature perfusion formula isolated organ perfusion container shown in Fig. 1；
Fig. 3 is the top view of constant-temperature perfusion formula isolated organ perfusion container shown in Fig. 1；
Fig. 4 is the partial sectional view of constant-temperature perfusion formula isolated organ perfusion container shown in Fig. 1.
10, fluid reservoir, the 11, first cavity, the 12, second cavity, 13, liquid outlet, 14, filling opening, 15, leakage fluid dram, 16, change
Hot import, 17, heat exchange outlet, 18, temperature-measuring port, 19, bottom cover, 191, sealing element, 20, support membrane, 21, leak hole.
Specific embodiment
To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing
Give better embodiment of the invention.But the invention can be realized in many different forms, however it is not limited to herein
Described embodiment.On the contrary, the purpose of providing these embodiments is that making to understand more the disclosure
Add thorough and comprehensive.
It should be noted that it can directly on the other element when element is referred to as " being fixed on " another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it, which can be, is directly connected to
To another element or it may be simultaneously present centering elements.On the contrary, when element is referred to as " directly existing " another element "upper",
There is no intermediary elements.Heretofore described " first ", " second " do not represent specific quantity and sequence, are only used for title
Differentiation.
It is shown such as Fig. 1 and Fig. 2, a kind of constant-temperature perfusion formula isolated organ perfusion container, comprising: fluid reservoir 10, fluid reservoir 10
Inside be separated to form the first cavity 11 and the second cavity 12, for accommodating perfusion liquid, the second cavity 12 is used for the first cavity 11
Heat exchange fluid is accommodated, the heat of heat exchange fluid can be transferred in the perfusion liquid in the first cavity 11 from the second cavity 12.
Above-mentioned constant-temperature perfusion formula isolated organ perfusion container in fluid reservoir 10 by being arranged the first cavity 11 and the second chamber
Body 12, the heat transfer of the heat exchange fluid in the second cavity 12 is to the first cavity 11, with this to the perfusion liquid in the first cavity 11
It is heated, compared with traditional constant-temperature perfusion formula isolated organ perfusion container, can effectively avoid the temperature of perfusion liquid from dropping to
Clinical trial temperature and the case where cause isolated organ to damage, so that isolated organ be made effectively to be saved.
Preferably, above-mentioned constant-temperature perfusion formula isolated organ perfusion container is applicable in vitro lungs Perfusion preservation, especially suitable
For the in vitro lungs Perfusion preservation of animal, certainly, above-mentioned constant-temperature perfusion formula isolated organ perfusion container be equally applicable to human body or
The Perfusion preservation of other isolated organs of animal, is not specifically limited herein.
Specifically, heat exchange fluid is chosen as water or anti-icing fluid.
Further, incorporated by reference to Fig. 2, the second cavity 12 is located on the periphery wall of the first cavity 11, or, 11 ring of the first cavity
Set on the periphery wall of the second cavity 12.Particularly, the second cavity 12 is located on the periphery wall of the first cavity 11, to increase heat biography
Area is passed, meanwhile, the periphery that the second cavity 12 surrounds the first cavity 11 can be played to the perfusion liquid heat preservation in the first cavity 11
Effect avoids the temperature of perfusion liquid from declining too fast, to extend the preservation duration of isolated organ.It is pointed out that the first chamber
There are many forms for the position that is oppositely arranged of body 11 and the second cavity 12, as long as the side of the side wall of the first cavity 11 and the second cavity 12
Wall part contact is able to achieve heat transfer, is not specifically limited herein.
In one embodiment, incorporated by reference to Fig. 2 to 3, above-mentioned constant-temperature perfusion formula isolated organ perfusion container further includes support membrane
20,10 upper installing hole of fluid reservoir (does not identify) in attached drawing, and the covering of support membrane 20 is mounted on mounting hole, also sets on fluid reservoir 10
Have for by the liquid outlet 13 of the first cavity 11 and isolated organ pipeline connection, support membrane 20 be equipped with for the first cavity 11
The leak hole 21 of connection.Isolated organ is placed on support membrane 20.Hold isolated organ container-contacting surface be support membrane 20, to from
The constriction of the such as in vitro lungs of body organ is smaller than hard material.Perfusion liquid in first cavity 11 is from liquid outlet 13 along pipeline stream
Enter in isolated organ, then flowed out from isolated organ, after back flowed back into the first cavity 11 through the leak hole 21 on support membrane 20,
Circulating for perfusion liquid is realized with this.
Specifically, please continue to refer to Fig. 2 and Fig. 3, mounting hole is set to the top of the first cavity 11, i.e. support membrane 20 is covered on
After mounting hole, support membrane 20 is located at the top of the first cavity 11, and accordingly, the perfusion liquid flowed out from isolated organ is direct through leak hole
It flows back into the first cavity 11.
Specifically, above-mentioned support membrane 20 uses medical soft film, and such as pellosil avoids causing to damage to isolated organ.
Further, above-mentioned support membrane 20 is recessed to the direction close to the first cavity 11, improves for isolated organ more
Accommodating space avoids isolated organ from being oppressed when stored and isolated organ is caused to damage.
Specifically, incorporated by reference to Fig. 3, multiple leak holes 21 are set on above-mentioned support membrane 20, to accelerate the back-flow velocity of perfusion liquid.
Particularly, leak hole 21 is arranged three, it is of course also possible to which 21 numbers of different leak holes are arranged according to actual needs, does not make to have herein
Body limits.
In one embodiment, incorporated by reference to Fig. 1, fluid reservoir 10 is equipped with the filling opening 14 for being connected to the first cavity 11,
Fluid reservoir 10 is equipped with the leakage fluid dram 15 for being connected to the first cavity 11.It, can when the perfusion liquid deficiency in the first cavity 11
Perfusion liquid is added in the first cavity 11 by filling opening 14, wherein addition manner includes that artificial addition manner and automation add
Add mode, in automation addition manner, filling opening 14 is connect by pipeline with liquid supply device, when perfusion liquid deficiency, can be grasped
Make liquid supply device and input perfusion liquid toward filling opening 14, additive amount when adding perfusion liquid to improve controls precision.Filling opening 14 is also
It can be used for adjusting dosing object.Meanwhile in isolated organ filling process, part perfusion liquid can be discharged from leakage fluid dram 15,
New perfusion liquid is added, into filling opening 14 again to realize that perfusion liquid is replaced.After completing isolated organ perfusion, it can will also be perfused
Liquid is emptied completely from leakage fluid dram 15, avoid perfusion liquid in the first cavity 11 long-time storage and lead to bacteria breed.
Further, fluid reservoir 10 is transparent tank body, and the side wall of fluid reservoir 10 is equipped with the capacity for indicating perfusion liquid
Silk-screen portion.By the silk-screen portion graduation position where observation perfusion liquid liquid level, the real time capacity of perfusion liquid can be intuitively obtained,
To be added in time to perfusion liquid.
Specifically, fluid reservoir 10 is chosen as transparent PMMA tank or transparent PC tank.
In one embodiment, incorporated by reference to Fig. 1 to 3, fluid reservoir 10 is equipped with and is respectively used to change with what the second cavity 12 was connected to
Hot import 16 and heat exchange outlet 17, heat exchange import 16 and heat exchange outlet 17 form heat exchange cycle with heating device piping connection respectively
Access.Heat exchange fluid successively flows back into the second cavity 12 through heat exchange outlet 17, heating device, heat exchange import 16, heat exchange fluid
It is flowed back into the second cavity 12 after being heated in heating device, to keep the heat exchange fluid temperature in the second cavity 12 constant, from
And more effectively guarantee that perfusion liquid reaches clinical trial required temperature section, it is further ensured that isolated organ can be protected effectively
It deposits.
Further, incorporated by reference to Fig. 1, fluid reservoir 10 is equipped with temperature-measuring port 18, is equipped in temperature-measuring port 18 for detecting perfusion
The temperature detecting unit (not showed that in attached drawing) of the temperature of liquid or heat exchange fluid.Particularly, temperature detecting unit is for detecting
The temperature of perfusion liquid, and temperature data is fed back into controller, controller controls heating device power according to above-mentioned temperature data
Size to change the temperature of heat exchange fluid, and then preferably controls the temperature of perfusion liquid, guarantees that the temperature of perfusion liquid maintains
In clinical trial required temperature section.
Further, incorporated by reference to Fig. 2, heat exchange outlet 17 is set to the lower part of the second cavity 12, and heat exchange import 16 is set to second
The top of cavity 12, can be better achieved the heat cycles of heat exchange fluid, so that heat exchange be better achieved.
In one embodiment, incorporated by reference to Fig. 1, Fig. 2 and Fig. 4, the bottom of fluid reservoir 10 be equipped with for by the second cavity 12 with
The opening (not identifying in attached drawing) of external world's connection, fluid reservoir 10 are removably equipped with the bottom cover 19 for covering opening.When complete
After being perfused at isolated organ, bottom cover 19 can be split out from fluid reservoir 10, the inside of the second cavity 12 is cleaned, to keep
Second cavity, 12 inner clean health, avoids bacteria breed.Wherein, there are many dismantling connection modes, as fastener connection type,
Mode, thread connecting mode etc. are snapped connection, is not specifically limited herein.
Further, incorporated by reference to Fig. 2 and Fig. 4, bottom cover is equipped with sealing element 191, and sealing element 191 is pressed on bottom cover 19 and opens
Between the outer rim of mouth.It can reinforce the leakproofness of fluid reservoir 10 by the way that sealing element 191 is arranged, prevent heat exchange fluid from leaking.
Specifically, above-mentioned sealing element 191 is chosen as sealing ring, and sealing ring is arranged along the outer rim of above-mentioned opening.Certainly, may be used also
The sealing element 191 taken other form, such as gasket seal.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of constant-temperature perfusion formula isolated organ perfusion container, which is characterized in that the constant-temperature perfusion formula isolated organ perfusion
Container includes: fluid reservoir, and the inside of the fluid reservoir is separated to form the first cavity and the second cavity, and first cavity is for holding
Perfusion liquid is set, for accommodating heat exchange fluid, the heat of the heat exchange fluid can transmit second cavity from second cavity
To in the intracorporal perfusion liquid of first chamber.
2. a kind of constant-temperature perfusion formula isolated organ perfusion container according to claim 1, which is characterized in that second chamber
Body is located on the periphery wall of first cavity, or, first cavity is located on the periphery wall of second cavity.
3. a kind of constant-temperature perfusion formula isolated organ perfusion container according to claim 1, which is characterized in that further include support
Film, the fluid reservoir upper installing hole, the support membrane covering are mounted on the mounting hole, are additionally provided with and are used on the fluid reservoir
By the liquid outlet of first cavity and isolated organ pipeline connection, the support membrane is equipped with for connecting with first cavity
Logical leak hole.
4. a kind of constant-temperature perfusion formula isolated organ perfusion container according to claim 1, which is characterized in that the fluid reservoir
It is equipped with the filling opening for being connected to first cavity, is additionally provided on the fluid reservoir for being connected to first cavity
Leakage fluid dram.
5. a kind of constant-temperature perfusion formula isolated organ perfusion container according to claim 4, which is characterized in that the fluid reservoir
For transparent tank body, the side wall of the fluid reservoir is equipped with the silk-screen portion for indicating the capacity of the perfusion liquid.
6. a kind of constant-temperature perfusion formula isolated organ perfusion container according to claim 1, which is characterized in that the fluid reservoir
It is equipped with and is respectively used to the heat exchange import that be connected to second cavity and exchanges heat export, the heat exchange import and described exchange heat out
Mouth forms heat exchange cycle access with heating device piping connection respectively.
7. a kind of constant-temperature perfusion formula isolated organ perfusion container according to claim 6, which is characterized in that the fluid reservoir
It is equipped with temperature-measuring port, the temperature detection for detecting the temperature of the perfusion liquid or the heat exchange fluid is equipped in the temperature-measuring port
Unit.
8. a kind of constant-temperature perfusion formula isolated organ perfusion container according to claim 6, which is characterized in that described to exchange heat out
Mouth is set to the lower part of second cavity, and the heat exchange import is set to the top of second cavity.
9. a kind of constant-temperature perfusion formula isolated organ perfusion container according to claim 1-8, which is characterized in that institute
The bottom of fluid reservoir is stated equipped with the opening for second cavity to be in communication with the outside, the fluid reservoir is removably equipped with use
In the bottom cover for covering the opening.
10. a kind of constant-temperature perfusion formula isolated organ perfusion container according to claim 9, which is characterized in that the bottom cover
It is equipped with sealing element, the sealing element is pressed between the bottom cover and the outer rim of the opening.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910284008.8A CN109907037B (en) | 2019-04-10 | 2019-04-10 | Constant temperature perfusion type isolated organ perfusion container |
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| CN201910284008.8A CN109907037B (en) | 2019-04-10 | 2019-04-10 | Constant temperature perfusion type isolated organ perfusion container |
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| CN109907037B CN109907037B (en) | 2022-02-01 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110506733A (en) * | 2019-08-26 | 2019-11-29 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Isolated organ perfusion container |
| CN110506734A (en) * | 2019-08-26 | 2019-11-29 | 陈静瑜 | Isolated organ perfusion equipment |
| CN111903664A (en) * | 2020-08-17 | 2020-11-10 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Isolated organ perfusion system and liver storage device |
| WO2021036738A1 (en) * | 2019-08-26 | 2021-03-04 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Ex vivo organ perfusion container |
| WO2021036742A1 (en) * | 2019-08-26 | 2021-03-04 | 无锡市人民医院 | Ex vivo organ perfusion apparatus |
| CN115777688A (en) * | 2022-11-03 | 2023-03-14 | 河南中医药大学第一附属医院 | Isolated myocardial tissue perfusion experiment system |
| CN117796389A (en) * | 2024-03-01 | 2024-04-02 | 青岛市中医医院(青岛市海慈医院、青岛市康复医学研究所) | Human organ tissue preservation equipment for urology department |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110506733A (en) * | 2019-08-26 | 2019-11-29 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Isolated organ perfusion container |
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| CN117796389A (en) * | 2024-03-01 | 2024-04-02 | 青岛市中医医院(青岛市海慈医院、青岛市康复医学研究所) | Human organ tissue preservation equipment for urology department |
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