CN207151736U - Liver perfusion heat exchange control device - Google Patents
Liver perfusion heat exchange control device Download PDFInfo
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- CN207151736U CN207151736U CN201720870239.3U CN201720870239U CN207151736U CN 207151736 U CN207151736 U CN 207151736U CN 201720870239 U CN201720870239 U CN 201720870239U CN 207151736 U CN207151736 U CN 207151736U
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Abstract
A kind of liver perfusion heat exchange control device is the utility model is related to, includes several membrane lungs of connection liquid storage container；The liquid outlet of the input connection liquid storage container of each membrane lung, output end connect the liquid inlet of liquid storage container；Also include controller, connect the refrigeration plant, heater and each temperature sensor of controller；The temperature data of the blood heat of the Wall Temperature of the liquid storage container collected, the fluid temperature of liquid storage container and each membrane lung is transferred to controller by each temperature sensor；Controller transmits refrigeration instruction according to temperature data to refrigeration plant, so that refrigeration plant freezes according to refrigeration instruction to the liquid of liquid storage container；Controller transmits heating instructions according to temperature data to heater, so that heater heats the liquid of liquid storage container according to heating instructions.The utility model meets the Liver Allograft Preservation demand of normal temperature perfusion and hypothermia perfusion, and regulation blood heat to preset temperature and is maintained within the scope of certain temperature, and good blood supply environment is provided for liver.
Description
Technical field
Machine perfusion technical field is the utility model is related to, more particularly to a kind of liver perfusion heat exchange control device.
Background technology
Machine perfusion is a kind of new organ preservation, drive manner, can simulate normal human body environment, there is provided in vitro
Organ oxygen and nutriment etc., and maintain good life state.Normal temperature perfusion be professional pass through frequently with technology hand
Section, but because Conservation environment is different, the external temperature of realistic simulation has relatively large deviation, is not easy constantly to be operated in a human body institute
The temperature conditionss needed.Temperature control is one of key factor for influenceing in vitro Liver Allograft Preservation, at present, although useful both at home and abroad
In the heat-exchange system for maintaining blood heat balance, but its temperature controlling range is small, and programming rate is slow, and it is quiet not to be suitable for low temperature
State stores.
In real process, inventor has found that at least there are the following problems in conventional art：Heat exchange in conventional art
Machine perfusion systems most is control manually, can not carry out dynamic automation regulation, and generally use water-bath carries out temperature
Degree control；The heating module of water-bath is directly contacted using 220V heating tube with liquid, easily causes aging circuit short circuit,
Certain application risk in medical field be present, and water-bath and liquid contact surface product are big, heat dissipation is high.Traditional machine perfusion
Hot swapping uses single channel, and heating is inefficient, and operating temperature range is small, is unfavorable for the preservation of in vitro liver.
Utility model content
Based on this, it is necessary to which not high for the efficiency of heating surface in tradition machinery perfusion hot swapping, operating temperature range is small
Technical problem, there is provided a kind of liver perfusion heat exchange control device.
To achieve these goals, on the one hand, the embodiments of the invention provide a kind of liver perfusion heat exchange control device,
Several membrane lungs including connecting liquid storage container；The liquid outlet of the input connection liquid storage container of each membrane lung, output end connection
The liquid inlet of liquid storage container；Also include controller, connect the refrigeration plant, heater and each temperature sensor of controller；
Each temperature sensor is by the blood heat of the Wall Temperature of the liquid storage container collected, the fluid temperature of liquid storage container and each membrane lung
Temperature data be transferred to controller；Controller transmits refrigeration instruction according to temperature data to refrigeration plant, so that refrigeration plant
The liquid of liquid storage container is freezed according to refrigeration instruction；Controller transmits heating instructions according to temperature data to heater,
So that heater heats the liquid of liquid storage container according to heating instructions.
Utility model has the following advantages that and beneficial effect：
The utility model liver perfusion heat exchange control device, heater and refrigeration is controlled to set by embedded controller
Standby, based on each temperature sensor being distributed in liquid storage container wall, liquid storage container and some membrane lungs, formation circulates back
Road, the liquid in blood and liquid storage container is carried out heat exchange when flowing through several membrane lungs, can overcome in conventional art and add
The thermal efficiency is not high, the small technical problem of operating temperature range, so improve machine perfusion system to maintain blood heat balance into
Efficiency in row heat exchanging process, expand operating temperature range, meet the Liver Allograft Preservation demand of normal temperature perfusion and hypothermia perfusion.Enter
One step, the utility model can adjust blood heat to preset temperature and maintain certain temperature during machine perfusion
In the range of degree, good blood supply environment is provided for liver.
Brief description of the drawings
By being more particularly described for the preferred embodiment of the present utility model shown in accompanying drawing, it is of the present utility model on address
Other purposes, feature and advantage will become more fully apparent.The identical reference instruction identical part in whole accompanying drawings, and
Deliberately accompanying drawing is not drawn by actual size equal proportion scaling, it is preferred that emphasis is the purport of the present invention is shown.
Fig. 1 is the heat exchange structure schematic diagram of the utility model liver perfusion heat exchange control device embodiment 1；
Fig. 2 is the concrete structure schematic diagram of the utility model liver perfusion heat exchange control device heat exchange；
Fig. 3 is the controller attachment structure schematic diagram of the utility model liver perfusion heat exchange control device；
Fig. 4 is the attachment structure signal of the temperature sensing circuit unit of the utility model liver perfusion heat exchange control device
Figure；
Fig. 5 is the operational amplification circuit of the temperature sensing circuit of the utility model liver perfusion heat exchange control device, filter
Wave circuit and the specific attachment structure schematic diagram of change-over circuit；
Fig. 6 be the utility model liver perfusion heat exchange control device temperature sensing circuit unit front stage circuits and
The specific attachment structure schematic diagram of voltage sampling circuit；
Fig. 7 is the specific attachment structure of the temperature-control circuit unit of the utility model liver perfusion heat exchange control device
Schematic diagram.
Embodiment
For the ease of understanding the utility model, the utility model is more fully retouched below with reference to relevant drawings
State.Preferred embodiment of the present utility model is given in accompanying drawing.But the utility model can come in fact in many different forms
It is existing, however it is not limited to embodiment described herein.On the contrary, the purpose for providing these embodiments is made to public affairs of the present utility model
Open content more thorough and comprehensive.
It should be noted that when an element is considered as " connection " another element, it can be directly to separately
One element and it is in combination be integrated, or may be simultaneously present centering elements.Term as used herein " installation ", " one
End ", " other end " and similar statement are for illustrative purposes only.
Unless otherwise defined, all of technologies and scientific terms used here by the article is led with belonging to technology of the present utility model
The implication that the technical staff in domain is generally understood that is identical.It is simply in term used in the description of the present utility model herein
The purpose of description specific embodiment, it is not intended that in limitation the utility model.Term as used herein " and/or " include
The arbitrary and all combination of one or more related Listed Items.
Referring to Fig. 1, Fig. 1 is that the heat exchange structure of liver perfusion heat exchange control device embodiment 1 of the present utility model shows
It is intended to, as shown in Figure 1.Liver perfusion heat exchange control device in the present embodiment 1, including connection liquid storage container 103 are some
Individual membrane lung 117；The liquid outlet of the input connection liquid storage container 103 of each membrane lung 117, output end connection liquid storage container 103
Liquid inlet；Also include controller 123, connect refrigeration plant 107, heater 105 and each temperature sensor of controller 123
119；Each temperature sensor 119 is by the Wall Temperature of liquid storage container 103 collected, the fluid temperature of liquid storage container and each membrane lung
The temperature data of 117 blood heat is transferred to controller 123；Controller 123 transmits according to temperature data to refrigeration plant 107
Refrigeration instruction, so that refrigeration plant 107 freezes according to refrigeration instruction to the liquid 101 of liquid storage container 103；Controller 123
Heating instructions are transmitted to heater 105 according to temperature data, so that heater 105 heats the liquid of liquid storage container according to heating instructions
Body 101.
The utility model liver perfusion heat exchange control system, heater and refrigeration is controlled to set by embedded controller
Standby, based on each temperature sensor being distributed in liquid storage container wall, liquid storage container and some membrane lungs, formation circulates back
Road, the liquid in blood and liquid storage container is set to carry out heat exchange when flowing through several membrane lungs.The utility model uses more membrane lungs
More hot switching path modes, further increase heat exchanger effectiveness, meanwhile, its it is contactless to the liquid in liquid storage container plus
Heat, and then the ageing equipment short circuit caused by direct contact liq heats is prevented, reduce the application risk of Medical Devices.
Further, by the refrigeration plant being connected with liquid storage container, the utility model liver perfusion heat exchange control is realized
Device processed compatibility hypothermia perfusion function while normal temperature perfusion is met, meet liver normal temperature perfusion and low temperature during preservation
The demand of perfusion.Further, the utility model embed controller, and if liquid storage container wall, liquid storage container liquid and
Each temperature sensor is laid in dry film lung, by the collection of temperature sensor, and by feedback of the information to controller, controller according to
The temperature information Intelligent adjustment heater of feedback or the power output of refrigeration plant, and then blood heat is adjusted to preset temperature
And maintain within the scope of certain temperature, the storage blood supply environment preserved is provided close to human body or utilized for liver.
According to embodiment 1, to further illustrate liver perfusion heat exchange control device of the present utility model, with reference to Fig. 1, ginseng
It is the concrete structure schematic diagram of the utility model liver perfusion heat exchange control device heat exchange to see Fig. 2, Fig. 2.
In a specific embodiment, liver perfusion heat exchange control device of the present utility model, including liquid storage container
203rd, controller 217, temperature sensor 211,219,223,225, centrifugal pump 213, refrigeration plant 207, membrane lung 215, heater
205 and three-way pipe 227.
Specifically, liquid storage container 203 can be but not limit the aluminum material fast using temperature is led, and body design is cylinder
Structure, container diameter 100mm, length 250mm, wall thickness 3mm, moisture storage capacity about 2L, water inlet are in funnel-form.Further, it is excellent
PI heating plates are selected as heater 205 but are not limited to PI heating plates, the optional two panels of PI heating plates, but it is not limited to two panels.PI
Heating leaf length is 314mm, width 120mm, rated power 150W, and operating voltage 24V, maximum operating temperature is 130 DEG C,
Two panels PI heating plates wrap up and the appearance of liquid storage container 203, if two panels IP heating plates are operated at full capacity simultaneously, are computed, heat transfer
Value theory can cause 3 degree of the heating per minute of the solution of 2L in liquid storage container 203.Specifically, refrigeration plant connection controller, is adopted
The temperature sensor 211 of the collection Wall Temperature of liquid storage container 203 is arranged in the screwed hole of the wall of liquid storage container 203, TEMP
Device 219 is built in the liquid 201 of liquid storage container 203, and temperature sensor 223 and temperature sensor 225 are built in membrane lung 215
In.Further, membrane lung number is preferably two, but is not limited to two.
Specifically, using the PI heating plates for being wrapped in liquid storage container outer surface, the contact area with liquid storage container is increased,
Reduce area of dissipation.Low pressure isolation heating is carried out to liquid by 24V DC voltages, is beneficial to prevent heating module from directly contacting
The equipment application risk such as short-circuit aging caused by liquid, reduce the medical thing caused by using high pressure in medical machinery application
Therefore while improve the efficiency of heating surface；Temperature sensor is distributed in container wall, liquid and membrane lung, and it is new accurately to detect this practicality
The temperature value at each key structure position of type liver perfusion heat exchange control device, and collecting temperature feedback of the information extremely controls in real time
Device, heating plate is adjusted by controller automatization and condenses the working condition of unit, intelligent and summary mechanically actuated, is easy to grasp
Make.
Further, the right side of tank 203 is provided with screwed hole, and size is G1/4 screw threads, but is not limited to this chi
Very little, right side is connected by biological flexible pipe with centrifugal pump 213, the liquid of the screwed hole of the water inlet of centrifugal pump 213 than liquid storage container 203
Outlet screwed hole is highly lower slightly, and due to water level vertical drop, liquid pours into centrifugal pump 213 and drives the work of centrifugal pump 213 automatically
Make.The delivery port of centrifugal pump 213 and biological flexible pipe vertical connection, the biological flexible pipe connection three-way pipe 227 of the delivery port of centrifugal pump 213,
Connect the water inlet of membrane lung 215 respectively using the adapter of three-way pipe 227, the delivery port of two membrane lungs 215 is connected by biological flexible pipe
Connect and be connected respectively to three-way pipe 227, connect the screwed hole at the top of liquid storage container 203 respectively by the adapter of three-way pipe 227.By
This, forms the water passage circulation system of a closure.
Specifically, by centrifugal pump, three-way pipe and two membrane lungs, closed cycle flowing is formed, can be with binary channels
Blood enter trip temperature transmission simultaneously, improve operating efficiency.Centrifugal pump work noise is low, compact-sized, uniform flow, and operating is flat
Surely, it is with small vibration, be advantageous to improve the control to liquid flow direction, there is provided the stability in perfusion heat exchanging process, contribute to blood
Maintain within the scope of specific temperature.
Liver perfusion heat exchange control device of the present utility model, using double membrane lung heat exchange methods, by being distributed in this
The real-time collecting temperature information of temperature sensor at device different structure position, it is intelligent according to the temperature information for feeding back to controller
The power output of PI heating plates and refrigeration plant is adjusted, and then the liquid in liquid storage container is heated or freezed.Further,
Liquid in liquid storage solution flows into double membrane lungs through centrifugal pump, completes heat transfer with blood in double membrane lungs, and regulation blood reaches
Preset temperature is simultaneously maintained in certain temperature range, is provided a good temperature range for liver, is kept the activity of liver function.
The utility model uses the thin PI heating plates light, power density is big of body, solves the technology that heating efficiency is slow in conventional art and asks
Topic, further increases the efficiency of heating surface, while optimizing heating structure, increases heating surface area by contactless mode, using bag
The mode for wrapping up in container outer surface reduces area of dissipation.
Further, the low pressure isolation mode of heating of PI heating plates, is solved straight using 220V heating modules in conventional art
Equipment short circuit aging caused by connecing heating liquid, and machined medical equipment breakdown problem, improve the safety that Medical Devices use
Property and reliability.Specifically, controller access refrigeration plant, can be achieved cryogenic refrigeration function, realizes that the utility model possesses often
Compatibility hypothermia perfusion while warm perfusion functional, expansion instrument operating temperature range, meet in vitro liver to different Conservation environments
Demand.
In a specific embodiment, the refrigeration plant 207 in the utility model liver perfusion heat exchange control system
For the miniature condensation unit of low-voltage direct, wherein comprising stainless steel plate type heat exchanger and being built in liquid storage container to liquid system
It is cold.Also include liquid level sensor 221, liquid storage container pouring liquid enters ports valve door 219 and liquid storage container pouring liquid tap
Valve 209, wherein, liquid level sensor 221, liquid storage container pouring liquid enter ports valve door 219 and liquid storage container pouring liquid row
The valve 209 that portals connects controller 217.Further, liquid level sensor 221, which is placed in liquid storage container 203, is used to detect liquid level
Highly.Liquid storage container liquid hand-hole valve switch 219 is arranged at the left side liquid hand-hole of liquid storage container 203, liquid storage container
203 liquid discharge orifice valves 209 are arranged at liquid storage container bottom liquid evacuation aperture.
Specifically, during the utility model liver perfusion heat exchange control device initialization, liquid storage container liquid hand-hole
The switch of valve 219 is opened, and liquid storage container liquid discharge orifice valve closes 209, is started to injection liquid 201 in liquid storage container 203,
Liquid capacity in the monitoring of containers of liquid level sensor 221, when reaching preset water level, the trigger signal of liquid level sensor 221 simultaneously passes
Controller 217 is handed to, controller 217 controls liquid storage container liquid hand-hole valve switch 219 to close, and stops fluid injection.Temperature passes
Sensor 211, temperature sensor 219, temperature sensor 223, temperature sensor 225 distinguish detection container wall, liquid 201 and film
Lung blood heat.When normal temperature irrigates, the driving of controller 217 drives two panels PI to heat piece driving circuit simultaneously, opens PI heating
Piece, refrigeration drive circuit is closed, is adjusted fluid temperature using pid control mode according to the temperature value that each temperature sensor gathers
To such as 36.8 DEG C of preset temperature, the liquid that the now driving of controller 217 centrifugal pump 213 flows through centrifugal pump passes through three-way pipe 227
Flow into membrane lung 215 and carry out heat exchange with the blood in membrane lung 215, until the blood heat in membrane lung 215 reaches preset temperature such as
36.8 DEG C and maintain constant temperature.
When temperature sensor 211 detects that Wall Temperature reaches 50 DEG C, send and stop heating signal to controller 217,
Closing heating piece driving circuit is controlled by controller 217, to prevent container from overheating.During hypothermia perfusion, controller opens cold low
DC micro condenses unit, closes PI heating piece driving circuits, liquid 201 is adjusted into preset temperature by pid control mode
Such as 4 DEG C, now controller 217 drives centrifugal pump 213 to flow through the liquid of centrifugal pump 213 and flows into membrane lung 215 by three-way pipe 227
Heat exchange is carried out with the blood in membrane lung 215, until the blood heat in membrane lung 215 reaches such as 4 DEG C of preset temperature and remains permanent
Temperature.After out of service, liquid storage container liquid discharge orifice valve 209 is opened by controller 217, closes liquid storage container liquid hand-hole
Valve 219 switchs, and discharges the waste liquid of liquid storage container 203.
The utility model liver perfusion heat exchange control device, by low-voltage direct minisize refrigeration equipment in liquid storage container
Liquid carry out cryogenic refrigeration, further expand operating temperature range of the present utility model.Meanwhile the miniature freezing machine of low-voltage direct
Group small volume, is easily installed, realizes light and handyization of the utility model structure, is easy to use.Further, low-voltage direct is miniature cold
Solidifying equipment acoustic noise is low, and low in energy consumption, refrigerating speed is fast, helps to provide good heat exchange environment, improves operating efficiency, reduces energy
Consumption, improve the security of medical machinery application.Further, the utility model is realized according to temperature value and pid control mode
Control to PI heating plates and the miniature condensation unit working condition of low-voltage direct, and then Intelligentized mechanical perfusion heat exchange
Journey, the different distributions of its temperature sensor, favorably the temperature under different component environments is acquired, and then realized to membrane lung blood
The precision of liquid temperature adjustment.Further, the utility model improves the precision and operating efficiency of blood heat regulation, realizes
The liver running environment really stablized close to human body is simulated, while meets the needs of in vitro liver is to different Conservation environments.
In a specific embodiment, liver perfusion heat exchange control device of the present utility model, it is to liquid storage container
The heater 205 that 203 liquid 201 carries out non-contact thermal can be infrared heater, to the liquid in liquid storage container 203
Body 201 carries out infrared heating.Infrared heater penetration power is good, and thermal efficiency friendship is good, can carry out local heating, saves the energy, can
Intelligentized control method, programming rate are fast.Further, heating process is more clean, non-secondary pollution, can prevent in machine perfusion
Liver is caused to damage in heat exchanging process.
Referring to Fig. 3, Fig. 4 and Fig. 5, Fig. 3 is the controller connection knot of the utility model liver perfusion heat exchange control device
Structure schematic diagram, Fig. 4 are that the attachment structure of the temperature sensing circuit unit of the utility model liver perfusion heat exchange control device is shown
It is intended to, Fig. 5 is operational amplification circuit, filter circuit and the change-over circuit tool of the utility model liver perfusion heat exchange control device
Attachment structure schematic diagram, as shown in the figure.
In a specific embodiment, such as Fig. 3, controller of the present utility model includes master chip 330, and connects respectively
Connect the temperature sensing circuit unit 310, temperature-control circuit unit 320 and refrigeration plant 340 of master chip.
Such as Fig. 4, temperature sensing circuit unit of the present utility model includes front stage circuits 410, change-over circuit 450 and each voltage
Sampling processing circuit 400.Specifically, voltage sample process circuit 400 includes voltage sampling circuit 420, the computing being sequentially connected
Amplifying circuit 430 and filter circuit 440, further, voltage sampling circuit 420 connects corresponding temperature sensor.Wherein, it is preceding
The input connection external power source of level circuit 410, output end connect each voltage sampling circuit 420, the input of change-over circuit 450
Connect each filter circuit 440, output end connection master chip.
As shown in figure 5, specifically, operational amplification circuit 430 includes being but being not limited to OPA2188 operation amplifiers
Device, the signal for being collected to temperature sensor are amplified.
Further, filter circuit includes being but being not limited to OPA2188 operational amplifiers, according to OPA2188's
RFI filters input characteristics, receives the temperature amplified signal that operational amplification circuit 430 transmits, temperature amplified signal is filtered,
Obtain the temperature value close to true testing result.Further, change-over circuit 450 includes being but being not limited to AD7705 moulds
Number conversion chip, for obtaining the filtered analog temperature signal of filter circuit 440, digital temperature is converted into by analog temperature signal
Signal is transferred to controller master chip, and master chip performs command adapted thereto according to the digital temperature signal got.
Liver perfusion heat exchange control device of the present utility model, according to including front stage circuits, each voltage sample processing electricity
Road and the temperature sensing circuit unit of change-over circuit, to the key of the liquid storage container wall of the device, liquid and membrane lung blood
Structure position carries out dynamic realtime temperature detection, and feeds back to controller, by controller according to each temperature value control heater with
And refrigeration plant work.And then realize to, to the intelligentized control method of blood heat regulation, being improved in machine perfusion heat exchanging process
Operating efficiency, be advantageous to adjust blood to design temperature and maintain in constant operating temperature range, optimize heat exchanging process
In stability.
Further, completed by using OPA2188 operational amplifiers and AD7705 modulus conversion chips to collecting
Temperature signal is amplified, filters and analog-to-digital conversion process, and OPA2188 operational amplifier category microchips, precision is high, application
Scope includes medical instrumentation, and AD7705 modulus conversion chip errors are smaller, using the compatible 3-line serial interfaces of SPIQSPI, just
It is connected in the master chip with the utility model controller, is advantageous to building for hardware configuration, the chip resolution is high, and low-voltage is low
Power consumption, suitable for instrument measurement.Liver perfusion heat exchange control device of the present utility model, by using but be not limited to
The temperature sensing circuit unit of OPA2188 and AD7055 chips, realize the compact of temperature sensing circuit unit hardware layout structure
Change, save hardware configuration space, reduce the utility model liver perfusion heat exchange control device volume, be easy to the device transposition
Different spaces, treatment is irrigated to liver and is preserved.
Referring to Fig. 6, Fig. 6 is the prime of the temperature sensing circuit unit of the utility model liver perfusion heat exchange control device
The attachment structure schematic diagram of circuit and voltage sampling circuit, as shown in the figure.
In a specific embodiment, the temperature sensing circuit list of the utility model liver perfusion heat exchange control device
Member includes front stage circuits and voltage sampling circuit.Specifically, front stage circuits can include REF3030A 2.5V reference power supply cores
Piece, the reference voltage output end connection voltage sampling circuit of its reference power supply chip.Further, voltage sampling circuit can be with
For H-bridge circuit, including first resistor R3, second resistance R4,3rd resistor R9 and the first electric capacity C2.First resistor R3 one end,
Second resistance R4 one end connects the first electric capacity C2 one end, and the first resistor R3 other end connects 3rd resistor R9 one end,
The 3rd resistor R9 other end, the first electric capacity C2 other end connect temperature sensor J1A first end, the R4's of second resistance
The other end connects the second end of temperature sensor.
The utility model liver perfusion heat exchange control device, the front stage circuits of its temperature sensing circuit unit use
REF3030A reference power supply chips, reference voltage is provided for voltage sampling circuit, voltage sampling circuit actually enter voltage with
Reference voltage compares to export appropriate sampling voltage, the size variation with temperature of the sampling voltage and change.
REF3030A reference power supply chip precision is higher, and in load circuit, temperature and time change, voltage can keep relative stability, and enter
And voltage sampling circuit can export accurate sampling voltage.H-bridge circuit of the present utility model can reduce connection temperature
The wire of sensor passes through the error to caused by the testing result of temperature sensor.Further, including REF3030A benchmark are electric
The front stage circuits combination H bridge voltage sample circuits of source chip, be advantageous to reduce the utility model liver perfusion heat exchange control dress
The substantial measurement errors of the temperature data for the temperature sensor collection put, are advantageous to controller and adjust blood according to actual temperature data
Liquid temperature degree.
In a specific embodiment, the temperature sensor of voltage sampling unit can be that PT1000 RTDs sense
Device, and be built in liquid storage container wall, liquid and membrane lung.The PT1000 platinum resistance temperature sensors that the utility model uses
Detection temperature scope is wider, and detection accuracy is higher, stable and reliable for performance, suitable for medical machinery, contributes to university degree practical
New operating temperature range, meet the needs of in vitro liver is to different storage temperatures, be advantageous to tie up under different Conservation environments
Hold the vigor function of liver.
Referring to Fig. 7, Fig. 7 is the connection of the temperature-control circuit unit of the utility model liver perfusion heat exchange control device
Structural representation, as shown in the figure.
In a specific embodiment, the utility model liver perfusion heat exchange control device, its temperature-control circuit
Unit includes, the second electric capacity C2, the 3rd electric capacity C3, the 4th resistance R2, the first triode N2, the first MOSN1 pipes and the first inductance
L1.Specifically, one end connection master chip of the 4th resistance, the other end connect the base stage of the first triode, the collection of the first triode
Electrode connects the first MOS grid, grounded emitter；The source electrode of one end of the second electric capacity, one end of the 3rd electric capacity and metal-oxide-semiconductor connects
Enter external power source；The other end ground connection of the other end of second electric capacity, the 3rd electric capacity；The leakage of one end connection metal-oxide-semiconductor of first inductance
Pole, other end connection heater.
Further, the master chip of controller controls the first triode N2 base stage electric according to each temperature value got
The dutycycle of pressure obtains different driving voltage driving PI heating plates and produces different heating powers, further, the temperature control
Circuit processed forms chopper circuit using the first triode N2 and the first metal-oxide-semiconductor N1, and chopper circuit output voltage passes through by the first electricity
Stable output voltage is obtained to drive heating plate to heat after the filter circuit of sense L1 and the 3rd electric capacity C3 compositions.Wherein, first
Metal-oxide-semiconductor N1 is used but is not limited to IRF5210SPBF, and power end the second electric capacity C1 and the 3rd electric capacity C2 are decoupling capacitor, respectively
Low-and high-frequency noise is filtered.
The utility model liver perfusion heat exchange control device, its temperature-control circuit effectively play tune by chopper circuit
The effect of pressure, while suppress grid side harmonic current noise, it is beneficial to the whole work efficiency for improving hardware circuit, saves energy
Source.Interference caused by reducing electric power network in heat exchanging process for the utility model, there is provided the stable driving voltage of heater,
The continual and steady work of heater is kept, is beneficial to maintain blood heat in machine perfusion heat exchanging process is carried out in setting
In the range of.
The utility model liver perfusion heat exchange control device, it is not high to overcome the efficiency of heating surface in conventional art, work temperature
The small technical problem of scope is spent, and then improves machine perfusion system to maintaining blood heat balance to carry out the effect in heat exchanging process
Rate, expand operating temperature range, meet the Liver Allograft Preservation demand of normal temperature perfusion and hypothermia perfusion.Further, in machine perfusion
During, regulation blood heat to preset temperature and is maintained within the scope of certain temperature, and good blood supply ring is provided for liver
Border.The utility model uses more hot switching path modes of more membrane lungs, further increases heat exchanger effectiveness, meanwhile, it is to storage
Liquid non-contact thermal in liquid container, and then solve ageing equipment short circuit, drop caused by direct contact liq heats
The application risk of low Medical Devices.
Above example only expresses several embodiments of the present utility model, and its description is more specific and detailed, but simultaneously
Therefore the limitation to utility model patent scope can not be interpreted as.It should be pointed out that the ordinary skill people for this area
For member, without departing from the concept of the premise utility, various modifications and improvements can be made, these belong to this reality
With new protection domain.Therefore, the protection domain of the utility model patent should be determined by the appended claims.
Claims (10)
- A kind of 1. liver perfusion heat exchange control device, it is characterised in that several membrane lungs including connecting liquid storage container；Each institute The input for stating membrane lung connects the liquid outlet of the liquid storage container, and output end connects the liquid inlet of the liquid storage container；Also include controller, connect the refrigeration plant, heater and each temperature sensor of the controller；Each temperature sensor by the Wall Temperature of the liquid storage container collected, the liquid storage container fluid temperature and The temperature data of the blood heat of each membrane lung is transferred to the controller；The controller is according to the temperature data to institute Refrigeration plant transmission refrigeration instruction is stated, so that the refrigeration plant enters according to the refrigeration instruction to the liquid of the liquid storage container Row refrigeration；The controller according to the temperature data to the heater transmit heating instructions so that the heater according to The heating instructions heat the liquid of the liquid storage container.
- 2. liver perfusion heat exchange control device according to claim 1, it is characterised in that the controller includes connection The master chip of the refrigeration plant, temperature sensing circuit unit, the temperature-control circuit unit of the master chip are connected respectively；The temperature sensing circuit unit includes front stage circuits, change-over circuit and each voltage sample process circuit；The voltage sample process circuit includes voltage sampling circuit, operational amplification circuit and the filter circuit being sequentially connected；Institute Voltage sampling circuit is stated also with the corresponding temperature sensor to be connected；The input connection external power source of the front stage circuits, output end connect each voltage sampling circuit；The conversion electricity The input on road connects each filter circuit, and output end connects the master chip.
- 3. liver perfusion heat exchange control device according to claim 2, it is characterised in that the voltage sampling circuit is H bridge voltage sample circuits；The H bridge voltages sample circuit includes first resistor, second resistance, 3rd resistor and the first electric capacity；The first resistor One end, one end of the second resistance connect one end of first electric capacity, described in the other end connection of the first resistor One end of 3rd resistor；The other end of the 3rd resistor, first electric capacity other end connection corresponding to the temperature pass The first end of sensor, the other end of the second resistance connect the second end of the temperature sensor.
- 4. liver perfusion heat exchange control device according to claim 2, it is characterised in that the temperature-control circuit list Member includes the second electric capacity, the 3rd electric capacity, the 4th resistance, the first triode, the first metal-oxide-semiconductor and the first inductance；One end connection master chip of 4th resistance, the base stage of other end connection first triode, described first The colelctor electrode of triode connects the grid of the first MOS, grounded emitter；One end of second electric capacity, the 3rd electricity The source electrode of one end of appearance and the metal-oxide-semiconductor accesses external power source；The other end of second electric capacity, the 3rd electric capacity it is another End ground connection；One end of first inductance connects the drain electrode of the metal-oxide-semiconductor, and the other end connects the heater.
- 5. the liver perfusion heat exchange control device according to Claims 1-4 any one, it is characterised in that also include Centrifugal pump and three-way pipe；The liquid storage container connects the centrifugal pump；The input of each membrane lung connects the centrifugation by each three-way pipe Pump, output end connect the liquid storage container by the three-way pipe.
- 6. liver perfusion heat exchange control device according to claim 5, it is characterised in that also including liquid storage container liquid Hand-hole valve switch and liquid storage container liquid discharge orifice valve switch；The controller respectively with the liquid storage container liquid hand-hole valve switch and the liquid storage container liquid discharge orifice Valve switch connects.
- 7. liver perfusion heat exchange control device according to claim 5, it is characterised in that also include gathering the liquid storage The liquid level sensor of tank fill level, the liquid level sensor connect the controller.
- 8. liver perfusion heat exchange control device according to claim 1, it is characterised in that the heater is to be wrapped in The PI heating plates of the liquid storage container outer surface；The refrigeration plant is the miniature condensation unit of low-voltage direct.
- 9. liver perfusion heat exchange control device according to claim 1, it is characterised in that gather the liquid storage container The temperature sensor of Wall Temperature is embedded in the wall of the liquid storage container or is attached on the wall of the liquid storage container.
- 10. liver perfusion heat exchange control device according to claim 9, it is characterised in that each temperature sensor For RTD PT1000 temperature sensors.
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| CN201720870239.3U CN207151736U (en) | 2017-07-17 | 2017-07-17 | Liver perfusion heat exchange control device |
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| CN201720870239.3U CN207151736U (en) | 2017-07-17 | 2017-07-17 | Liver perfusion heat exchange control device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109597442A (en) * | 2018-11-28 | 2019-04-09 | 广东丁沃生医疗器械有限公司 | A kind of temperature control system for liver perfusion |
| CN109907037A (en) * | 2019-04-10 | 2019-06-21 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Constant-temperature perfusion formula isolated organ perfusion container |
| CN110583620A (en) * | 2019-08-26 | 2019-12-20 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Temperature adjusting device, method and device for mechanical perfusion of isolated lung |
| WO2021036742A1 (en) * | 2019-08-26 | 2021-03-04 | 无锡市人民医院 | Ex vivo organ perfusion apparatus |
-
2017
- 2017-07-17 CN CN201720870239.3U patent/CN207151736U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109597442A (en) * | 2018-11-28 | 2019-04-09 | 广东丁沃生医疗器械有限公司 | A kind of temperature control system for liver perfusion |
| CN109907037A (en) * | 2019-04-10 | 2019-06-21 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Constant-temperature perfusion formula isolated organ perfusion container |
| CN109907037B (en) * | 2019-04-10 | 2022-02-01 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Constant temperature perfusion type isolated organ perfusion container |
| CN110583620A (en) * | 2019-08-26 | 2019-12-20 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Temperature adjusting device, method and device for mechanical perfusion of isolated lung |
| WO2021036742A1 (en) * | 2019-08-26 | 2021-03-04 | 无锡市人民医院 | Ex vivo organ perfusion apparatus |
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