CN206978567U - A kind of machine perfusion medicament slow release pump installation - Google Patents
A kind of machine perfusion medicament slow release pump installation Download PDFInfo
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- CN206978567U CN206978567U CN201720931075.0U CN201720931075U CN206978567U CN 206978567 U CN206978567 U CN 206978567U CN 201720931075 U CN201720931075 U CN 201720931075U CN 206978567 U CN206978567 U CN 206978567U
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Abstract
The utility model provides a kind of machine perfusion medicament slow release pump installation, including passes sequentially through organ save set, centrifugal pump, oxygenator, medicament slow release device, accurate degasification bubbler, flow control valve, the pressure sensor of perfusion pipeline circulation connection；Liquid taking port is respectively arranged between the organ save set, centrifugal pump, between centrifugal pump, membrane oxygenator；The centrifugal pump is connected by irrigating pipeline with organ save set.The utility model improves the limitation of single temperature model regulation and control, it is possible to achieve three kinds of temperature model regulation and control；The design of medicament slow release pump installation accurately can carry out pharmaceutical intervention for different livers；Filter is high polymer material, can effective filtration, purification perfusion liquid；The setting of liquid taking port can sample Testing index at any time；Constant current centrifugal pump can provide effective, controllable continuous pouring；The dosage that this system operation is simple, perfusion path is short, cyclic design greatlys save perfusion liquid, save perfusion cost.
Description
Technical field
It the utility model is related to a kind of medicine equipment, more particularly to a kind of machine perfusion medicament slow release pump installation.
Background technology
Since professor Starzl in 1963 completes first case human body liver transfer operation in the world, liver transfer operation has been applied to clinic
Exceed half a century, liver transplant turns into the unique effective means for treating whole end-stage liver disease.However, transplanting waiter's number
Increase and donor organ shortage between contradiction be still the serious bottleneck for restricting organ transplant career development.Expansion standard
Donor（extended criteria donor, ECD）The liver in source（Including old-age group for liver, fatty liver etc.）It is to expand liver
The important measures in dirty source, but ECD livers and post-transplantation PNF, EAD high rate are closely related often goes out of use.With
Updating for organ preservative fluid and preserving type, ECD livers return the people visual field again, are gradually applied to transplanting.
Traditional static cold preservation（static cold storage, SCS）The overwhelming majority can effectively be preserved and supply liver, but it is right
For the liver in ECD sources, its Preservation injury and postoperative Primary gastrointrestinal lymphoma（primary nonfunction, PNF）、
Ischemic bile duct disease equivalent risk is apparently higher than machine perfusion（machine perfusion, MP）According to it is temperature controlled not
Together, MP can be divided into three kinds of normal temperature, Mild Hypothermal and low temperature modes, and hypothermic machine perfusion（Hypothermic machine
perfusion, HMP）It is applied to emerge a large amount of liver perfusion devices on the current domestic and international market of clinical test earliest, such as
Life port, Organ Assist, Organ Ox, and clinic is successfully applied to, obtain concept clinical curative effect, but these livers
Device for casting is expensive only with same temperature pattern, it is difficult at home and abroad transplants center and widelys popularize.
How to assess and safeguard donor organ quality is to transplant the significant challenge that career development faces.For deep spy
Beg for research MP to donor liver, the especially evaluation of the liver in ECD sources with repair mechanism, it is necessary to which substantial amounts of basic grind with clinic
Study carefully.The document report of the liver perfusion device on being designed for zoopery is limited at present, by Lifeport, Organ
Its cost is too high applied to zoopery for the liver perfusion devices such as Assist and Organ Ox, while can not realize three kinds of temperature
Mode adjusting.
Utility model content
For problem present in background technology, the utility model provides the in vitro oxygen carrying machinery of a new animal's liver and filled
Injection system, medicament slow release pump installation is added, realizes three kinds of temperature model regulation and control, and pharmaceutical intervention is carried out to the liver in ECD sources,
Preferably evaluation is with inquiring into its repair mechanism.
Particular technique effect of the present utility model is as follows：
A kind of machine perfusion medicament slow release pump installation, including pass sequentially through perfusion pipeline communication organ save set, from
Heart pump, oxygenator, medicament slow release device, degasification bubbler, flow control valve, pressure sensor；The organ save set and from
Liquid taking port is respectively arranged between heart pump, between centrifugal pump and oxygenator.
As preference：The organ save set is detachable structure, including separable internal's supporting bracket
With outside constant temperature box；Portal vein connector and bile duct connector are placed with the organ supporting bracket；The constant temperature box bottom is set
There is temperature control circuit board；Temperature probe is provided with the organ supporting bracket；The constant temperature box inside groove can add frozen water mixing
Thing, bottom are provided with temperature control circuit board, and temperature probe is positioned over organ supporting bracket, monitor in real time and regulate and control to preserve liquid temperature degree.
As preference：The portal vein connector is two-way connector, the pressure sensor and portal vein connector
Connection.
As preference：Also include bile collection device, the bile collection device connects with bile duct connector；The courage
Pipe connections are two-way connector.
As preference：The medicament slow release device include be sequentially communicated by medicament slow release pipeline drug response pond,
One-way flow control valve, filter, high-tension drug reservoir；Polyvinyl chloride guarantor is provided with outside the high-tension drug reservoir
Guard post；The hat type medicine feeding hole connected with high-tension drug reservoir is provided with the polyvinyl chloride guard column；The medicine delays
Release device is connected by drug response pond with perfusion pipeline.
As preference：The degasification bubbler includes shell, fiber filtration membrane is horizontally arranged with the shell, and it is pushed up
Portion's facility has venthole.
As preference：The perfusion pipeline is Heparin coated circuits or medical polyvinyl pipeline.
As preference：The medicament slow release pipeline is medical polyvinyl pipeline.
The utility model is according to normal temperature（36-37℃）, Mild Hypothermal（28-32℃）With low temperature（4-10℃）Three kinds of different temperatures
Pattern is irrigated to liver, and centrifugal pump provides power, and liver perfusate is carried out oxygen conjunction by oxygenator, and medicine is through medicament slow release pump
Device accurately injects the perfusion liquid after oxygen closes, and is pumped via pipes into liver, the perfusion liquid of vena hepatica outflow is through heparin coating pipe outside liver
Road/medical polyvinyl pipeline is back to centrifugal pump, completes During Cpb.
The utility model advantageous effects are as follows：1st, the medicament slow release pump installation of the system is by adding different medicines
Personalised drug intervention and pharmaceutical research are carried out to ECD livers；2nd, pressure sensor, flow control valve are provided with the system
And centrifugal pump, the minimum control of portal vein perfusion flow is realized low discharge low pressure to ECD livers to 0.1 ml/min/g liver
Perfusion, it can significantly alleviate high pressure high flow capacity machine perfusion to caused by ECD supplies liver and damage；3rd, degasification bubbler is adopted in the system
, can effective filtration, purification perfusion liquid with natural macromolecular material；The 4th, liquid taking port and bile collection device are set in this pipe-line system,
Liver enzyme in perfusion liquid, oxygen consumption and molecular marker are detected by collecting the perfusion liquid in circulation loop, with evaluating liver quality；5、
Organ save set is provided with temperature control device in the system, it is possible to achieve three kinds of low temperature, Mild Hypothermal and normal temperature temperature models are adjusted
Control is irrigated to liver, changes the limitation of single temperature model regulation and control；6th, this system operation is simple, irrigates path
Short, cyclic design greatlys save the dosage of perfusion liquid, saves perfusion cost.
Brief description of the drawings
Fig. 1 is the utility model structure diagram；
Fig. 2 is the structural representation of medicine delayed release device in the utility model；
Wherein：1 is organ save set, and 2 be perfusion pipeline, and 3 be centrifugal pump, and 4,6 be liquid taking port, and 5 be oxygenator, 7
It is degasification bubbler for medicament slow release device, 8,9 be flow control valve, and 10 be pressure sensor, and 11 be bile collection device, and 12 are
Organ supporting bracket, 13 be constant temperature box, and 14 be drug response pond, and 15 be medicament slow release pipeline, and 16 be one-way flow control valve, 17
It is polyvinyl chloride guard column for filter, 18,19 be high-tension drug reservoir, and 20 be hat type medicine feeding hole, and 21 be that portal vein connects
Fitting, 22 be bile duct connector.
Embodiment
The utility model is described further with reference to embodiment and accompanying drawing.
A kind of machine perfusion medicament slow release pump installation, including pass sequentially through perfusion pipeline 2 connect organ save set 1,
Centrifugal pump 3, oxygenator 5, medicament slow release device 7, degasification bubbler 8, flow control valve 9, pressure sensor 10；The organ preserves
Liquid taking port 6 is respectively arranged between device 1 and centrifugal pump 3, between centrifugal pump 3 and oxygenator 5, is easy to sampling to detect actual enter liver
The indexs such as partial pressure of oxygen, blood gas analysis.
The organ save set 1 is detachable structure, including separable internal's supporting bracket 12 and outside it is permanent
Warm box 13；The organ supporting bracket 12 is provided with portal vein connector 21 and bile duct connector 22, portal vein connector 21 and courage
Pipe connections 22 can be connected with organ supporting bracket 12 and may also placed on organ supporting bracket 12；The bottom of constant temperature box 13 is provided with temperature
Spend control board；Temperature probe is provided with the organ supporting bracket 12；The inside groove of constant temperature box 13 can add frozen water mixing
Thing, bottom are provided with temperature control circuit board, and temperature probe is positioned over organ supporting bracket 12, monitor in real time and regulate and control preservation liquid temperature
Degree.
The portal vein connector 21 is two-way connector, and the pressure sensor 10 is connected with portal vein connector 21.
Also include bile collection device 11, the bile collection device 11 connects with bile duct connector 22；The bile duct connects
Fitting 22 is two-way connector.
The medicament slow release device 7 includes passing through drug response pond 14, the unidirectional stream that medicament slow release pipeline 15 is sequentially communicated
Control valve 16, filter 17, high-tension drug reservoir 19；Polyvinyl chloride is provided with outside the high-tension drug reservoir 19
Guard column 18；The hat type medicine feeding hole 20 connected with high-tension drug reservoir 19 is provided with the polyvinyl chloride guard column 18；
The medicament slow release device 7 is connected by drug response pond 14 with perfusion pipeline 2.
The degasification bubbler 8 includes shell, fiber filtration membrane is horizontally arranged with the shell, and its top facility has
Stomata.
The perfusion pipeline 2 is Heparin coated circuits or medical polyvinyl pipeline.
The medicament slow release pipeline 15 is medical polyvinyl pipeline.
The organ supporting bracket 12 is provided with portal vein connector and bile duct connector, and vena portae hepatica connector connects for two-way
Part, connected respectively with liver portal vein, pressure sensor 10, bile is two-way connector through bile duct connector, respectively with liver
Bile duct connects with bile collection device 11, and bile enters bile collection device 11；The inside groove of constant temperature box 13 can be directly added into ice
Aqueous mixtures, bottom are provided with temperature control circuit board, and temperature probe is positioned over organ supporting bracket 12, monitor in real time and regulate and control liver
Temperature needed for preservation such as 0-10 DEG C of low temperature, 22-32 DEG C of Mild Hypothermal, 36-38 DEG C of normal temperature, temperature-controlled precision ± 0.1 DEG C.
Take appropriate perfusion liquid to add to the organ supporting bracket 12 in oxygen carrying machine perfusion system first, at this moment connect organ
Perfusion pipeline 2 between save set 1, centrifugal pump 3, it is not direct with organ save set 1 positioned at one end of organ save set 1
Connect, but be located in organ supporting bracket 12 below perfusion liquid liquid level, then the driving force through centrifugal pump, perfusion liquid is successively through oxygen
Clutch, medicament slow release device enter degasification bubbler, and edge perfusion pipeline is back to organ supporting bracket after excluding bubble, makes entirely to irrigate
Perfusion liquid is filled in system pipeline, centrifugal pump is stopped.After being obtained for liver, it is statically placed in organ supporting bracket, liver portal vein
Perfusion pipeline is accessed by portal vein connector, biliary tract is drawn by biliary tract connector and is connected to bile collection device, centrifugal pump
Restart to start, perfusion liquid starts the cycle over perfusion from vena portae hepatica, and perfusion liquid is closed through peroxide enters liver, carries out during perfusion
During pharmaceutical intervention, medicine enters high-tension drug reservoir through hat type medicine feeding hole, balloon expandable, medicine is promoted using elastic recovery force
Thing, after circular filter filters, the one-way flow control valve control medicament slow release time, medicine imports medicine through conduit and perfusion liquid
Thing reaction tank is sufficiently mixed, and its evaluation and repair process are participated in into liver through irrigating the processes such as pipe-line system.
Although it is organ save set that this specification, which has more used 1,2 be perfusion pipeline, and 3 be centrifugal pump, and 4,6 is equal
It is oxygenator for liquid taking port, 5,7 be medicament slow release device, and 8 be degasification bubbler, and 9 be flow control valve, and 10 be pressure sensor,
11 be bile collection device, and 12 be organ supporting bracket, and 13 be constant temperature box, and 14 be drug response pond, and 15 be medicament slow release pipeline,
16 it is one-way flow control valve, 17 is filter, 18 is polyvinyl chloride guard column, and 19 be high-tension drug reservoir, and 20 be cap
Formula medicine feeding hole, portal vein connector 21, the grade term of bile duct connector 22, but it is not precluded from the possibility using other terms.Make
With these terms just for the sake of more easily describing essence of the present utility model, it is construed as what any one was added
Limitation is all disagreed with the utility model spirit.
It should be appreciated that the part that this specification does not elaborate belongs to prior art.
It should be appreciated that the above-mentioned description for preferred embodiment is more detailed, therefore can not be considered to this
The limitation of utility model patent protection domain, one of ordinary skill in the art are not departing under enlightenment of the present utility model
Under the ambit that the utility model claims are protected, replacement or deformation can also be made, is each fallen within of the present utility model
Within protection domain, the scope of the present utility model that is claimed should be determined by the appended claims.
Claims (8)
- A kind of 1. machine perfusion medicament slow release pump installation, it is characterised in that：Including passing sequentially through perfusion pipeline（2）The organ of connection Save set（1）, centrifugal pump（3）, oxygenator（5）, medicament slow release device（7）, degasification bubbler（8）, flow control valve（9）, pressure Force snesor（10）；The centrifugal pump（3）And oxygenator（5）Between, oxygenator（5）With medicament slow release device（7）Between respectively It is provided with liquid taking port（4、6）.
- 2. machine perfusion medicament slow release pump installation as claimed in claim 1, it is characterised in that：The organ save set（1） For detachable structure, including separable internal's supporting bracket（12）With outside constant temperature box（13）；The organ supporting bracket （12）On be placed with portal vein connector（21）With bile duct connector（22）；The constant temperature box（13）Bottom is provided with temperature control electricity Road plate；The organ supporting bracket（12）On be provided with temperature probe.
- 3. machine perfusion medicament slow release pump installation as claimed in claim 2, it is characterised in that：The portal vein connector（21） For two-way connector, the pressure sensor（10）With portal vein connector（21）Connection.
- 4. machine perfusion medicament slow release pump installation as claimed in claim 2, it is characterised in that：Also include bile collection device （11）, the bile collection device（11）With bile duct connector（22）Connection；The bile duct connector（22）For two-way connector.
- 5. machine perfusion medicament slow release pump installation as claimed in claim 1, it is characterised in that：The medicament slow release device（7） Including passing through medicament slow release pipeline（15）The drug response pond being sequentially communicated（14）, one-way flow control valve（16）, filter （17）, high-tension drug reservoir（19）；The high-tension drug reservoir（19）It is provided with polyvinyl chloride guard column outside（18）； The polyvinyl chloride guard column（18）On be provided with and high-tension drug reservoir（19）The hat type medicine feeding hole of connection（20）；It is described Medicament slow release device（7）Pass through drug response pond（14）With irrigating pipeline（2）Connection.
- 6. machine perfusion medicament slow release pump installation as claimed in claim 1, it is characterised in that：The degasification bubbler（8）Including Shell, fiber filtration membrane is provided with the shell, and its top facility has venthole.
- 7. machine perfusion medicament slow release pump installation as claimed in claim 1, it is characterised in that：The perfusion pipeline（2）For liver Element coating pipeline or medical polyvinyl pipeline.
- 8. machine perfusion medicament slow release pump installation as claimed in claim 1, it is characterised in that：The medicament slow release pipeline（15） For medical polyvinyl pipeline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720931075.0U CN206978567U (en) | 2017-07-28 | 2017-07-28 | A kind of machine perfusion medicament slow release pump installation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720931075.0U CN206978567U (en) | 2017-07-28 | 2017-07-28 | A kind of machine perfusion medicament slow release pump installation |
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| Publication Number | Publication Date |
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| CN206978567U true CN206978567U (en) | 2018-02-09 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108157352A (en) * | 2018-02-11 | 2018-06-15 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Multiple organ one perfusion equipment |
| CN109597442A (en) * | 2018-11-28 | 2019-04-09 | 广东丁沃生医疗器械有限公司 | A kind of temperature control system for liver perfusion |
| CN115885972A (en) * | 2022-10-24 | 2023-04-04 | 中国科学院理化技术研究所 | Organ perfusion preservation equipment |
-
2017
- 2017-07-28 CN CN201720931075.0U patent/CN206978567U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108157352A (en) * | 2018-02-11 | 2018-06-15 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Multiple organ one perfusion equipment |
| CN109597442A (en) * | 2018-11-28 | 2019-04-09 | 广东丁沃生医疗器械有限公司 | A kind of temperature control system for liver perfusion |
| CN115885972A (en) * | 2022-10-24 | 2023-04-04 | 中国科学院理化技术研究所 | Organ perfusion preservation equipment |
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