CN209546716U - A kind of toy organ room temperature machine perfusion system - Google Patents
A kind of toy organ room temperature machine perfusion system Download PDFInfo
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- CN209546716U CN209546716U CN201920136113.2U CN201920136113U CN209546716U CN 209546716 U CN209546716 U CN 209546716U CN 201920136113 U CN201920136113 U CN 201920136113U CN 209546716 U CN209546716 U CN 209546716U
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Abstract
The utility model discloses toy organ room temperature machine perfusion systems, including shell, organ storehouse, perfusion circulation line is connect with organ storehouse, filter device and oxygenation device, organ storehouse is a closed cavity, organ is formed with perfusion inlet at the top of storehouse, priming outlet is formed in bottom, priming outlet is connect with the peristaltic pump being arranged on perfusion circulation line, the outlet end of peristaltic pump is connect with filter device input end, the outlet end of filter device is connect by the way that circulation line is perfused with oxygenation device, the outlet end and perfusion inlet of oxygenation device are connected to perfusion circulation line and are equipped with a four-way pipe, one heater of external installation in organ storehouse is for constant temperature inside organ storehouse.The utility model has the beneficial effects that single pump-single cycle perfusion facilitates control perfusion liquid global cycle amount and peristaltic velocity, abundant oxygen, which is closed, increases fuel factor with temperature is maintained, perfusion liquid temperature is accurately adjusted by heater in perfusion circulation line, and being capable of real-time monitoring perfusion liquid temperature and organ state.
Description
Technical field
The utility model belongs to technical field of medical equipment, more particularly, to a kind of toy organ room temperature machine perfusion system
System.
Background technique
Currently, organ transplant is to treat the important method of same disease, by taking liver transfer operation as an example, liver transfer operation is treatment a variety of ends
The most effective means of end-stage liver disease.With the expansion of operative indication and the growth of amount for surgical, organ shortage, which becomes, restricts me
The major reason of state's liver transfer operation development.
Based on the situation for liver shortage, how many scholars expands for liver source if beginning one's study, and uses including trial
What is be previously considered to is not suitable for the marginal donor of operation.Now, the most frequently used specified liver storage in vitro mode is static cold preservation
(static cold storage, SCS), SCS are that UW liquid (the University of is poured into after obtaining organ
Wisconsin solution), and organ is soaked in UW liquid, it is static under 4 DEG C or so of cryogenic conditions to save.SCS is logical
It crosses reduction cell activity and inhibits cell metabolism, and add antioxidant and carry out scavenging activated oxygen to play the work of protection cell
With.Although effect is reliable and stable when SCS is used to save quality outstanding healthy liver, when being used to save marginal donor,
Postoperative there is primary liver graft nonfunction and the probability of multiple complications and will increase.In view of the limitation of SCS, to improve edge
The quality of donor, many scholars research and development using room temperature machine perfusion (Normothermic machine perfusion,
NMP) for storage in vitro for liver.
Currently, the standard that the animal organ's room temperature machine perfusion system used for scientific research is not unified, self-control is normal mostly
Warm machine perfusion system, there is many problems, wherein mainly including the following:
1. temperature maintains aspect, the heat exchanger volume for saving human organ is larger not to be suitable for saving petty action sundries
It is slow to keep the temperature adjusting temperature Rate using water-bath by official, and occupied space is big, and warm water easily breeds bacterium, is unfavorable for maintaining perfusion dress
The cleaning set；
2. toy organ mass is small, blood vessels caliber is narrow, and the difficulty of perfusion is big and intravascular pressure not easy to control, causes
Artificial damage；
3. removing the bubble in perfusion liquid using bubble remove device, embolism is avoided, but perfusion liquid cannot be removed
Solid impurity；
4. the part in device is all placed in external environment, the wind of perfusion liquid pollution is increased when using perfusion liquid
Danger, and perfusion operation program is lengthy and jumbled.
Utility model content
The purpose of the utility model is to provide a kind of structures, and simple, easy to operate, raising organ saves safety, in real time inspection
Survey the toy organ room temperature machine perfusion system of the organ state during saving.
The technical solution of the utility model is as follows:
A kind of toy organ room temperature machine perfusion system, including shell, organ storehouse, it connect with organ storehouse perfusion circulation pipe
Road, filter device and oxygenation device, the organ storehouse, perfusion circulation line, filter device and oxygenation device are mounted in shell,
The organ storehouse is a closed cavity, is formed with perfusion inlet at the top of the organ storehouse, is formed with priming outlet in bottom, institute
It states priming outlet and is connect with the peristaltic pump being arranged on perfusion circulation line, the outlet end of the peristaltic pump and filter device import
End connection is with for continuing to convey perfusion liquid to filter device, the outlet end of the filter device passes through perfusion circulation line and oxygen
It attaches together and sets connection, the outlet end of the oxygenation device is connect to inject organ storehouse for the perfusion liquid after closing oxygen with perfusion inlet
It is interior, a four-way pipe is equipped on the perfusion circulation line, four ports of the four-way pipe are separately connected perfusion inlet, oxygen closes
Device, detection device and sample tap, one heater of external installation in the organ storehouse is for constant temperature inside organ storehouse；
The oxygenation device includes oxygen pipeline and oxygenator, the external oxygen tank of oxygen pipeline, on oxygen pipeline
Equipped with oxygen regulatory component for adjusting the content of perfusion liquid and oxygen in oxygenator；
The detection device includes detector, pressure-sensitive probe and temperature-sensing probe, and the temperature-sensing probe is arranged in organ storehouse
Portion, the pressure-sensitive probe are connect with four-way pipe, and the pressure-sensitive probe, temperature-sensing probe are electrically connected for monitoring perfusion with detector
Liquid temperature and organ portal vein pressure.
In the above-mentioned technical solutions, it is equipped with heating folder in the section of perfusion inlet in the perfusion circulation line, and is filling
It infuses circulation line and is equipped with muff.
In the above-mentioned technical solutions, the heater surrounding is round, is below taper, and heating element uses nickel filament,
Two bread are with heat-conducting insulation material.
In the above-mentioned technical solutions, it is taper that the top of the heater, which is cylindrical, lower part, and heater with a thickness of
1cm。
In the above-mentioned technical solutions, the filter device uses microthrombus filter.
In the above-mentioned technical solutions, the outside in the organ storehouse is equipped with warehouse lid.
In the above-mentioned technical solutions, the oxygenator uses hollow fiber membrane oxygenator.
The utility model has the advantages and positive effects of:
1. single pump-single cycle perfusion facilitates control perfusion liquid global cycle amount and peristaltic velocity, abundant oxygen closes and maintains temperature
Increase fuel factor, perfusion liquid temperature is accurately adjusted by the heater of abnormity in perfusion circulation line, and pass through temperature-sensing probe
And pressure-sensitive probe real-time monitoring perfusion liquid temperature and organ state.
2. organ warehouse lid seals organ storehouse, there is good insulation effect, foreign matter is avoided to enter in perfusion liquid, pollution perfusion
Liquid.
3. device is arranged in shell, with external insulation, contamination probability is reduced, heat insulation effect is improved, cuts and occupy little space,
It is simple and convenient, convenient transportation.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the toy organ room temperature machine perfusion system of the utility model；
Fig. 2 repairs liver portal vein pressure measurement figure during being experiment；
Fig. 3 repairs liver during being experiment and generates bile measurement figure；
Perfusion liquid blood glucose measures spirogram during Fig. 4 is experiment；
Perfusion liquid pH measurement figure during Fig. 5 is experiment；
Fig. 6 is postoperative 7d, 14d rat blood serum glutamic-pyruvic transaminase (ALT) measurement figure of Rat Liver Transplantation；
Fig. 7 is postoperative 7d, 14d rat blood serum glutamic-oxalacetic transaminease (AST) measurement figure of Rat Liver Transplantation.
In figure:
1, organ 2, organ storehouse 3, heater
4, bile 5, peristaltic pump 6, perfusion circulation line
7, filter device 8, oxygen tank 9, oxygen regulatory component
10,11 oxygenator of oxygen pipeline, 12, muff
13, heating folder 14, four-way pipe 15, sample tap
16, pressure-sensitive probe 17, detector 18, temperature-sensing probe
19, shell
Specific embodiment
The utility model is described in further detail below in conjunction with specific embodiment.It should be appreciated that described herein
Specific embodiment is used only for explaining the utility model, is not used to limit the utility model, is never limited in the utility model
Protection scope.
Embodiment 1
As shown, the toy organ room temperature machine perfusion system of the utility model, including shell 19, organ storehouse 2, with
The connection perfusion of organ storehouse 2 circulation line 6, filter device 7 and oxygenation device, organ storehouse 2, perfusion circulation line 6, filter device 7
It is mounted in shell 19 with oxygenation device, organ storehouse 2 is a closed cavity, and the top in organ storehouse 2 is formed with perfusion inlet, the bottom of at
Portion is formed with priming outlet, and priming outlet is connect with the peristaltic pump 5 being arranged on perfusion circulation line 6, the outlet end of peristaltic pump 5
It is connect with 7 input end of filter device with for continuing to convey perfusion liquid to filter device 7, the outlet end of filter device 7 passes through filling
Note circulation line 6 is connect with oxygenation device, and the outlet end of oxygenation device is connect for the perfusion after closing oxygen with perfusion inlet
Liquid injects in organ storehouse 2, is equipped with a four-way pipe 14 on perfusion circulation line 6, four ports of four-way pipe 14 are separately connected filling
Inlet, oxygenation device, detection device and sample tap 15, one heater 3 of external installation in organ storehouse 2 is in organ storehouse 2
Portion's constant temperature.
Above-mentioned oxygenation device includes oxygen pipeline 10 and oxygenator 11, the external oxygen tank 8 of oxygen pipeline 10, in oxygen pipeline
10 are equipped with oxygen regulatory component 9 for adjusting the content of perfusion liquid and oxygen in oxygenator 11；
Above-mentioned detection device includes that detector 17, pressure-sensitive probe 16 and temperature-sensing probe 18, temperature-sensing probe 18 are arranged in organ
Inside storehouse 2, pressure-sensitive probe 16 is connect with four-way pipe 14, and pressure-sensitive probe 16, temperature-sensing probe 18 are electrically connected with detector 17 to be used for
Monitor perfusion liquid temperature and 1 portal vein pressure of organ.
It further says, is equipped with heating folder 13 in the section of perfusion inlet in perfusion circulation line 6, and in perfusion circulation pipe
Road 6 is equipped with muff 12, muff 12 is provided on perfusion circulation line 6, conducive to the maintenance of temperature.
It further says, the heater 3 of the present apparatus is the electric heater 3 of controllable temperature, with the customization of silicon rubber heater 3
At.Heating element uses nickel filament, and two bread are heat-treated with heat-conducting insulation material through hot press moulding forming and aging, because
This is with very high reliability.It uses surrounding to be round, is conducive to stablize maintenance temperature below for the heater 3 of taper, and can essence
Really adjustment heater 3 temperature, heater 3 with a thickness of 1cm, the miniaturization small in size for being conducive to device for casting, in perfusion liquid
Heating folder 13, and the add insulation sleeve 12 outside all pipelines, the more conducively maintenance of temperature and body are connected before into organ 1 outside pipeline
The growth and proliferation of outer cell.When environment temperature is 20-24 DEG C, 3 heating temperature of heater is 58-65 DEG C, can control perfusion
Liquid temperature is 36.5-38.0 DEG C, standard has been formulated for temperature, convenient for operation.
It further says, filter device 7 uses microthrombus filter, and it is miscellaneous can to remove the solids such as the thrombus in perfusion liquid
Matter, while can also prevent bubble from entering perfusion liquid, to reach the double effects of removal solid impurity and bubble.
Other researchers mostly use bubble remove device to remove the bubble in perfusion liquid to prevent embolism, but solid without processing
The device of body impurity, the present apparatus use microthrombus filter, the i.e. solid impurities such as thrombus in removing perfusion liquid, are also prevented from simultaneously
Bubble enters perfusion liquid, reaches the double effects of solid impurity and bubble in removal perfusion liquid, and function is more comprehensive.Meanwhile this
Strainer in the filter device 7 of device is nylon material, and aperture is 100 μm, can permit red blood cell and mescenchymal stem cell is suitable
Benefit passes through.
It further says, oxygenator 11 uses hollow fiber membrane oxygenator 11, so that blood flows outside doughnut
The shearing force of blood can be reduced, Erythrocyte Damage is mitigated, effective oxygen closes area in 0.2m2, by oxygenator 11 make perfusion liquid with
Oxygen convection current, oxygen closes ability by force to meet the oxygen demand of organ 1, and priming volume is small.
Further say, in perfusion circulation line 6, only with a 5 control loop flow of peristaltic pump and peristaltic velocity,
It is closed with abundant oxygen and temperature is maintained to increase fuel factor, it is single compared with the double pump used in currently available technology-Two-way Cycle perfusion
Pump-single cycle is easy to use, simple, and peristaltic pump 5 is circulation power, and perfusion liquid is only contacted without with pump line and contacts pump
Body, reduces the risk of perfusion liquid pollution, and experimental cost is low.
It is following (by taking the liver of rat as an example) in the concrete operations using the utility model:
(1) it before the perfusion system of starting the utility model, is first repeated douche can injection system 5 times using 1L physiological saline；
(2) after filling perfusion liquid and drug by perfusion inlet, start heater 3 to heat perfusion liquid, in liver storehouse
To detect the temperature in liver storehouse, control filling temperature (is maintained insertion temperature-sensing probe 18 at 36.5-38 DEG C with simulating in regular
The temperature of normal physiological activity)；
(3) start oxygenation device, control oxygen flow is maintained at 30mL/min, and oxygenation device runs 30min with drain
Bubble in road；
(4) by the piping connection of liver and perfusion system, liver is swum in liver storehouse, drive of the perfusion liquid in peristaltic pump 5
It under dynamic, is filtered through microthrombus filter, oxygenator 11 connects through portal vein to liver perfusion, bile duct and liver storehouse after making red blood cell oxygen carrier
It connects to collect bile 4 for draining, pressure-sensitive 16 real-time detection portal vein pressure of probe start to carry out liver room temperature perfusion, perfusion
Maintaining portal vein pressure in the process is 10-14cm H2O；
(5) it after reaching the 8h holding time, closes peristaltic pump 5 and stops perfusion, remove liver later, then close oxygenator
11 and heater 3；
(6) perfusion liquid in the perfusion circulatory system is emptied, the circulatory system is perfused with 1L sterile distilled water repeated flushing later,
Up to no blood and impurity remain, 1% peracetic acid soln for then adding 100mL soaks entire perfusion internal system pipeline
Bubble disinfection, and with ultraviolet light irradiation 1h.
During liver carries out room temperature perfusion experiment in vitro, perfusion liquid temperature will maintain 36.5-38 DEG C always, and fill
Perfusion liquid sample is left and taken from sample tap 15 per hour when note starts and after starting, and leaves and takes bile 4.
Wherein, for the perfusion liquid used during the experiment for DMEM/F12 culture medium, culture medium includes phosphate-buffered pair, energy
Enough maintain the pH stable of perfusion liquid.
Slowly decline as shown in Fig. 2, perfusion starts back door pulse pressure, stablizes after 1h at 10-14cm (water column).
As shown in figure 3, liver persistently has the generation of bile 4 in room temperature filling process, 1h is less, 2h generates bile
4 at most, and the generation of bile 4 tends towards stability after 3h.
As shown in figure 4, blood glucose slowly reduces in perfusion liquid, to illustrate that liver cell works normally, perfusion liquid is gradually consumed
In glucose.
As shown in figure 5, the pH of perfusion liquid is slowly reduced, stablize 7.40.
As shown in Figure 6, Figure 7, it using cold preservation group as control group, is washed down in liver after blood using UW liquid, is soaked in UW liquid
In, the cryo-conservation in 4 DEG C of environment.Rat Liver Transplantation operation is carried out after saving same time in vitro, in Rat Liver Transplantation
Postoperative 7d, 14d carry out liver function test, and ALT, AST level of room temperature perfusion are significantly lower than cold preservation group, illustrate that this system saves
Liver effect it is more preferable.
Embodiment 2
On the basis of embodiment 1, the outside in liver storehouse is equipped with warehouse lid to prevent perfusion liquid dirty for sealing liver storehouse
It contaminates and influences perfusion experiment.
The spatially relative terms such as "upper", "lower", "left", "right" have been used in embodiment for ease of explanation, have been used for
Relationship of the elements or features relative to another elements or features shown in explanatory diagram.It should be understood that in addition to figure
Shown in except orientation, spatial terminology is intended to include the different direction of device in use or operation.For example, if in figure
Device be squeezed, the element for being stated as being located at other elements or feature "lower" will be located into other elements or feature "upper".
Therefore, exemplary term "lower" may include both upper and lower orientation.Device, which can be positioned in other ways, (to be rotated by 90 ° or position
In other orientation), it can be interpreted accordingly used herein of the opposite explanation in space.
Moreover, the relational terms of such as " first " and " second " or the like are used merely to one with another with identical
The component of title distinguishes, without necessarily requiring or implying between these components there are any this actual relationship or
Sequentially.
One embodiment of the utility model is described in detail above, but the content is only the utility model
Preferred embodiment should not be considered as limiting the scope of the present invention.It is all to be made according to application scope of the utility model
Equivalent variations and improve etc., should still belong within the patent covering scope of the utility model.
Claims (7)
1. a kind of toy organ room temperature machine perfusion system, it is characterised in that: connect including shell, organ storehouse, with organ storehouse
Circulation line, filter device and oxygenation device, the organ storehouse, perfusion circulation line, filter device and oxygenation device peace is perfused
In shell, the organ storehouse is a closed cavity, is formed with perfusion inlet at the top of the organ storehouse, is formed in bottom
Priming outlet, the priming outlet be arranged in perfusion circulation line on peristaltic pump connect, the outlet end of the peristaltic pump and
The connection of filter device input end is with for continuing to convey perfusion liquid to filter device, the outlet end of the filter device passes through perfusion
Circulation line is connect with oxygenation device, and the outlet end of the oxygenation device is connect for the perfusion after closing oxygen with perfusion inlet
Liquid injects in organ storehouse, a four-way pipe is equipped on the perfusion circulation line, four ports of the four-way pipe are separately connected
Perfusion inlet, oxygenation device, detection device and sample tap, one heater of external installation in the organ storehouse is in organ storehouse
Portion's constant temperature；
The oxygenation device includes oxygen pipeline and oxygenator, and the external oxygen tank of oxygen pipeline is equipped on oxygen pipeline
Oxygen regulatory component is for adjusting the content of perfusion liquid and oxygen in oxygenator；
The detection device includes detector, pressure-sensitive probe and temperature-sensing probe, and the temperature-sensing probe is arranged inside organ storehouse, institute
It states pressure-sensitive probe to connect with four-way pipe, the pressure-sensitive probe, temperature-sensing probe are electrically connected for monitoring perfusion liquid temperature with detector
Degree and organ portal vein pressure.
2. toy organ room temperature machine perfusion system according to claim 1, it is characterised in that: recycled in the perfusion
Pipeline is equipped with heating folder close to perfusion inlet section, and is equipped with muff on perfusion circulation line.
3. toy organ room temperature machine perfusion system according to claim 2, it is characterised in that: the heater surrounding
It is below taper to be round, heating element uses nickel filament, and two bread are with heat-conducting insulation material.
4. toy organ room temperature machine perfusion system according to claim 3, it is characterised in that: the thickness of the heater
Degree is 1cm.
5. toy organ room temperature machine perfusion system described in any one of -4 according to claim 1, it is characterised in that: institute
Filter device is stated using microthrombus filter.
6. toy organ room temperature machine perfusion system according to claim 5, it is characterised in that: outside the organ storehouse
Portion is equipped with warehouse lid.
7. toy organ room temperature machine perfusion system according to claim 6, it is characterised in that: the oxygenator uses
Hollow fiber membrane oxygenator.
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| CN201920136113.2U CN209546716U (en) | 2019-01-27 | 2019-01-27 | A kind of toy organ room temperature machine perfusion system |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111480644A (en) * | 2019-01-27 | 2020-08-04 | 宋红丽 | Normal-temperature mechanical perfusion combined with gene modification for repairing small animal organ system by stem cells |
| GB2591784A (en) * | 2020-02-06 | 2021-08-11 | Univ Strathclyde | Organ transport apparatus |
| CN115885972A (en) * | 2022-10-24 | 2023-04-04 | 中国科学院理化技术研究所 | Organ perfusion preservation equipment |
| CN116617482A (en) * | 2023-04-28 | 2023-08-22 | 天津大学温州安全(应急)研究院 | ECMO combined blood purification device for animals and application method thereof |
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2019
- 2019-01-27 CN CN201920136113.2U patent/CN209546716U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111480644A (en) * | 2019-01-27 | 2020-08-04 | 宋红丽 | Normal-temperature mechanical perfusion combined with gene modification for repairing small animal organ system by stem cells |
| CN111480644B (en) * | 2019-01-27 | 2024-02-27 | 宋红丽 | Normal temperature mechanical perfusion and gene modification combined stem cell repair small animal organ system |
| GB2591784A (en) * | 2020-02-06 | 2021-08-11 | Univ Strathclyde | Organ transport apparatus |
| CN115885972A (en) * | 2022-10-24 | 2023-04-04 | 中国科学院理化技术研究所 | Organ perfusion preservation equipment |
| CN115885972B (en) * | 2022-10-24 | 2024-09-03 | 中国科学院理化技术研究所 | Organ perfusion preservation apparatus |
| CN116617482A (en) * | 2023-04-28 | 2023-08-22 | 天津大学温州安全(应急)研究院 | ECMO combined blood purification device for animals and application method thereof |
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