CN203724222U - Large animal in-vitro working heart double-channel perfusion experimental equipment - Google Patents
Large animal in-vitro working heart double-channel perfusion experimental equipment Download PDFInfo
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- CN203724222U CN203724222U CN201420034355.8U CN201420034355U CN203724222U CN 203724222 U CN203724222 U CN 203724222U CN 201420034355 U CN201420034355 U CN 201420034355U CN 203724222 U CN203724222 U CN 203724222U
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- 230000010412 perfusion Effects 0.000 title claims abstract description 62
- 210000002216 heart Anatomy 0.000 title claims abstract description 59
- 241001465754 Metazoa Species 0.000 title claims abstract description 33
- 238000000338 in vitro Methods 0.000 title abstract 3
- 230000010100 anticoagulation Effects 0.000 claims abstract description 22
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 18
- 239000001301 oxygen Substances 0.000 claims abstract description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 17
- 210000003492 pulmonary vein Anatomy 0.000 claims abstract description 13
- 239000008280 blood Substances 0.000 claims abstract description 12
- 210000004369 blood Anatomy 0.000 claims abstract description 12
- 210000001147 pulmonary artery Anatomy 0.000 claims abstract description 12
- 238000012360 testing method Methods 0.000 claims abstract description 12
- 210000004072 lung Anatomy 0.000 claims abstract description 8
- 238000002474 experimental method Methods 0.000 claims description 39
- 230000009977 dual effect Effects 0.000 claims description 23
- 230000037361 pathway Effects 0.000 claims description 23
- 230000002792 vascular Effects 0.000 claims description 20
- 230000036316 preload Effects 0.000 claims description 18
- 238000010992 reflux Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 241000005139 Lycium andersonii Species 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 210000000709 aorta Anatomy 0.000 abstract description 6
- 238000010171 animal model Methods 0.000 abstract description 3
- 210000004351 coronary vessel Anatomy 0.000 abstract 3
- 241000282472 Canis lupus familiaris Species 0.000 abstract 1
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- 229940127219 anticoagulant drug Drugs 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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Abstract
The utility model relates to large animal in-vitro working heart double-channel perfusion experimental equipment, in particular to in-vitro working heart double-channel perfusion experimental equipment for pigs or large dogs or other large experimental animals. The equipment has the advantages that oxygen enrichment anticoagulation using amount is saved, heart working performance can be tested comprehensively, and needed equipment is simple. The equipment is characterized in that anticoagulation closed loop equipment comprises a pulmonary artery pipe which is connected with a first testing instrument, an artificial lung machine with an oxygen supply device, a blood pump, a coronary artery perfusion column and a coronary artery pipe in sequence, physiological solution closed loop equipment comprises an aorta pipe which is connected with a back load column, a second testing instrument, a physiological solution pump, a front load column and a pulmonary vein pipe in sequence, a constant temperature system is connected with the coronary artery perfusion column, the back load column and the front load column respectively, and the constant temperature system further comprises a constant temperature groove.
Description
Technical field
This utility model belongs to Basic medicine experiment technical field, is specifically related to the large-scale experiment animal isolated working heart dual pathways perfusion experiment equipment such as a boar or large-scale dog.
Background technology
Isolated working heart experiment is cardiovascular experiment common technology, can get rid of the impact of the systems such as nerve, breathing, endocrine, observes the reaction of heart for various environmental factorss or medicine factor itself, is the best experimental technique of organ level in circulation science experiment.
In classical work heart experimental technique, heart due to afterload pressure, will make part physiological solution be fed into coronary circulation after pumping containing oxygen physiological solution, and the physiological solution of this part keeps blood supply and the oxygen supply of working heart.Such experimental technique is in toy work excess of the heart is tested, and because heart size is little, cardiac muscle is thin, and oxygen consumption is few, generally uses the physiological solution of inorganic salt and glucose configuration, and the direct oxygenation of mode with oxygen to blow can make toy heart remain active.
Classical isolated working heart experimental technique, in research previously, for medical science applied progress has accumulated a large amount of data, has advanced blood circulation physiology, pathology and pharmacological development greatly.But along with the progress of science, the kind limitation of minitype animal experiment has just day by day highlighted out.The minitype animal experiment that is usually used in isolated working heart experiment mainly contains mice, rat, Cavia porcellus and rabbit, former three belongs to rodent, rabbit belongs to Lagomorph, all belong to the mammal of lower grade, aspect dissection, physiology, pathology and the pharmacology of heart with the differing greatly of the mankind.Now generally believe, the big-and-middle-sized laboratory animals such as dog and pig are more approaching in cardiovascular each side and the mankind, especially at medical science emerging fields such as transplantation medicines, use pig can better react the variation of the factors such as various treatment conditions and disease at human body as laboratory animal.
But because the heart size of larger animal is large, myocardium bed thickness, oxygen consumption is large, need to use anticoagulation perfusion.And the oxygen exchange that uses anticoagulation perfusion just to require end user's work pulmonary system to keep, in large animal langendorff cardiac perfusion experiment, generally needs oxygen enrichment anticoagulation 300～600ml/min.And according to Theoretical Calculation, in the time using isolated working heart experimental technique, more than the oxygen enrichment anticoagulant blood volume needing is about 5L/min, the exchange area of the artificial lung system of use cannot be realized to laboratory condition greatly especially.This makes large animal isolated working heart experiment be difficult to realize.
Summary of the invention
This utility model is exactly for the problems referred to above, and a kind of oxygen enrichment anticoagulation use amount of saving is provided, and can test more comprehensively heart working performance, the simple large animal isolated working heart dual pathways perfusion experiment equipment of equipment needed thereby.
For realizing above-mentioned purpose of the present utility model, this utility model adopts following technical scheme, this utility model comprises anticoagulation closed circuit equipment and physiological solution closed circuit equipment, and the constant temperature system being connected with physiological solution closed circuit equipment with anticoagulation closed circuit equipment, it is characterized in that: described anticoagulation closed circuit equipment comprises pulmonary artery pipe, pulmonary artery pipe is connected with arteria coronaria pipe with the first test instrunment, the artificial lung machine with apparatus of oxygen supply, blood pump, coronary perfusion post successively; Described physiological solution closed circuit equipment comprises initiatively vascular, and initiatively vascular is connected with afterload post, the second test instrunment, physiological solution pump, preload post and pulmonary vein pipe successively; Described constant temperature system is connected with coronary perfusion post, afterload post and preload post respectively; Described constant temperature system also comprises temperature chamber.
As a kind of preferred version of the large animal isolated working heart of this utility model dual pathways perfusion experiment equipment, described coronary perfusion post top is provided with the first limit for height reflux pipe that same blood pump entrance is communicated with; The top of described preload post is provided with the second limit for height reflux pipe that same physiological solution pump intake is communicated with.
As the another kind of preferred version of the large animal isolated working heart of this utility model dual pathways perfusion experiment equipment, on described afterload post, vertically be placed with at least two afterload limit for height branch roads that are communicated with the second test instrunment, on each afterload limit for height branch road, be provided with open and close valve.
As the third preferred version of the large animal isolated working heart of this utility model dual pathways perfusion experiment equipment, described arteria coronaria pipe is arranged in active vascular, and described active vascular comprises the top tube and down tube that are threaded connection.
Further, described arteria coronaria pipe comprises the hard straight tube being arranged in vascular initiatively, and the lower end of hard straight tube is provided with two flexible pipes, and two hose end are provided with intubate head, is provided with the loop-like or helical form Os Draconis of hard in described flexible pipe.
The beneficial effect of the large animal isolated working heart of this utility model dual pathways perfusion experiment equipment: 1, the large animal isolated working heart of this utility model dual pathways perfusion experiment equipment is by arranging anticoagulation closed circuit equipment and physiological solution closed circuit equipment, arteria coronaria perfusion loop and physiological solution perfusion loop are separated into two parts, can save enriched-oxygen anticoagulated blood; And, by the arteria coronaria perfusion loop and the physiological solution perfusion loop that independently arrange, can carry out respectively multiple different physiology test.
2, by the first limit for height reflux pipe being set on coronary perfusion post top; The second limit for height reflux pipe is set on the top of preload post, can makes the too high partial reflux of liquid in coronary perfusion post and preload post, prevent that blood pump and physiological solution pump work power from changing and affect cardiac perfusion preload.
3, by the afterload limit for height branch road on afterload post, be convenient to regulate the afterload of the work heart, can be for observing the working condition of different afterload hearts.
4, the arteria coronaria pipe of the large animal isolated working heart of this utility model dual pathways perfusion experiment equipment is arranged at initiatively in vascular, and the active vascular top tube and down tube that are set to be threaded connection; In the time carrying out arteria coronaria intubate, can first lower pipe be fixed on to eminence by screw thread; Complete after intubate until double comb arteries and veins, more lower pipe is fixed on to lower, and carry out intubate with aorta, easy to use.
5, be set to have the flexible pipe of Os Draconis by arteria coronaria pipe, be both convenient to arteria coronaria to carry out intubate work, can avoid again arteria coronaria pipe to be subject to the impact of aorta overpressure.
Brief description of the drawings
Fig. 1 is the structural representation of the large animal isolated working heart of this utility model dual pathways perfusion experiment equipment.
Fig. 2 is heart cathetrization view.
Fig. 3 is the structural representation of active vascular and arteria coronaria pipe.
Fig. 4 is the structural representation of the flexible pipe of arteria coronaria pipe.
In accompanying drawing, 1 is constant temperature system, 2 is temperature chamber, 3 is pulmonary vein pipe, 4 is active vascular, 5 is thermostatic water-jacket, 6 is arteria coronaria pipe, 7 is preload post, 8 is the second test instrunment, 9 is open and close valve, 10 is physiological solution pump, 11 is the second limit for height reflux pipe, 12 is afterload limit for height branch road, 13 is afterload post, 14 is pulmonary artery pipe, 15 is coronary perfusion post, 16 is the first limit for height reflux pipe, 17 is blood pump, 18 is the first test instrunment, 19 is artificial lung machine, 20 is apparatus of oxygen supply, 21 is intubate head, 22 is flexible pipe, 23 is lower pipe, 24 is fixture block, 25 is hard straight tube, 26 is screw thread, 27 is Os Draconis, 28 is upper pipe.
The aortas that the arteria coronaria, 400 that the pulmonary vein, 300 that in Fig. 2,100 pulmonary artery, 200 that are heart are heart is heart are heart.
Detailed description of the invention
This utility model comprises anticoagulation closed circuit equipment and physiological solution closed circuit equipment, and the constant temperature system 1 being connected with physiological solution closed circuit equipment with anticoagulation closed circuit equipment, it is characterized in that: described anticoagulation closed circuit equipment comprises pulmonary artery pipe 14, pulmonary artery pipe 14 is connected with arteria coronaria pipe 6 with the first test instrunment 18, the artificial lung machine 19 with apparatus of oxygen supply 20, blood pump 17, coronary perfusion post 15 successively; Described physiological solution closed circuit equipment comprises initiatively vascular 4, and initiatively vascular 4 is connected with pulmonary vein pipe 3 with afterload post 13, the second tester 8 devices, physiological solution pump 10, preload post 7 successively; Described constant temperature system 1 is connected with coronary perfusion post 15, afterload post 13 and preload post 7 respectively; Described constant temperature system 1 also comprises temperature chamber 2.
As a kind of preferred version of the large animal isolated working heart of this utility model dual pathways perfusion experiment equipment, described coronary perfusion post 15 tops are provided with the first limit for height reflux pipe 16 that same blood pump 17 entrances are communicated with; The top of described preload post 7 is provided with the second limit for height reflux pipe 11 that same physiological solution pump 10 entrances are communicated with.
As the another kind of preferred version of the large animal isolated working heart of this utility model dual pathways perfusion experiment equipment, on described afterload post 13, vertically be placed with at least two afterload limit for height branch roads 12 that are communicated with the second tester 8 devices, on each afterload limit for height branch road 12, be provided with open and close valve 9.
As the third preferred version of the large animal isolated working heart of this utility model dual pathways perfusion experiment equipment, described arteria coronaria pipe 6 is arranged in active vascular 4, and described active vascular 4 comprises the upper pipe 28 and the lower pipe 23 that connect by screw thread 26.
The upper inner of described lower pipe 23 is provided with screw thread 26, and described upper pipe 28 outer surface bottoms and top are respectively arranged with screw thread 26.Be convenient to moving up and down of lower pipe 23.
The lower end of described upper pipe 28 is provided with the fixture block 24 that the same pipe 28 upper ends coordinate.Fixture block 24 can prevent that lower pipe 23 from dropping, easy to use.
Further, described arteria coronaria pipe 6 comprises the hard straight tube 25 being arranged in vascular 4 initiatively, and the lower end of hard straight tube 25 is provided with two flexible pipe 22, two flexible pipe 22 ends and is provided with intubate 21, is provided with the loop-like or helical form Os Draconis 27 of hard in described flexible pipe 22.
Described flexible pipe 22 can be made up of silica gel.
Described constant temperature system 1 comprises constant-temperature water circulating device, and constant-temperature water circulating device is connected with the thermostatic water-jacket 5 being arranged at outside coronary perfusion post 15, preload post 7 and afterload post 13.
Use procedure below in conjunction with the large animal isolated working heart of brief description of the drawings this utility model dual pathways perfusion experiment equipment: preparing experiment medicine, reagent, fill the liquid in each pipeline, open artificial lung machine 19 to anticoagulation oxygenation, open constant temperature system 1 equilibrium system temperature.
Get animal hearts, be placed in rapidly 4 DEG C of ringer solutions and stop fighting, then the screw thread 26 of the same lower pipe 23 pipe 28 upper ends is connected, lower pipe 23 is fixed on higher position, and arteria coronaria pipe 6 is come out; Carefully discharge the air in arteria coronaria pipe 6, carry out double comb arteries and veins intubate, and slightly fix; Again the screw thread 26 of the same lower pipe 23 pipe 28 lower ends is connected, then lower pipe 23 is inserted in aorta; , pulmonary artery pipe 14 is connected with pulmonary vein meanwhile, pulmonary vein pipe 3 is connected with pulmonary vein.
Heart is hung up, adjusted pressure, start perfusion, and heart is fought again with electricity irritation.
Oxygen enrichment anticoagulation is fed into by arteria coronaria pipe 6 in the arteria coronaria of heart, for heart provides nutrition and oxygen energy; Anticoagulation is put out by pulmonary artery, enters the first test instrunment 18 detect by pulmonary artery pipe 14, and the anticoagulation after detection enters 19 oxygenations of artificial lung machine, and the oxygen enrichment anticoagulation after oxygenation enters coronary perfusion post 15 under blood pump 17 effects; Coronary perfusion post 15 maintains the perfusion pressure of coronary perfusion loop, and the oxygen enrichment anticoagulation in coronary perfusion post 15 is flowed out by the lower end of coronary perfusion post 15, and by arteria coronaria pipe 6, the arteria coronaria of heart is carried out to perfusion, completes the circulation of arteria coronaria perfusion.
Physiological solution is injected the pulmonary vein of heart by pulmonary vein pipe 3, put out by aorta again, in active vascular 4 enters afterload post 13, enter successively the second tester 8 devices, physiological solution pump 10 and preload post 7 by afterload post 13 again, preload post 7 maintains the perfusion pressure of physiological solution priming line, physiological solution is flowed out by the lower end of preload post 7, and by pulmonary vein pipe 3, the pulmonary vein of heart is carried out to perfusion, completes the circulation of physiological solution perfusion.
When experiment, can, by opening the afterload limit for height branch road 12 of differing heights, provide different afterloads to heart, thereby be convenient to study the working condition of heart under different situations.
Be understandable that, above about specific descriptions of the present utility model, only for being described, this utility model is not limited to the described technical scheme of this utility model embodiment, those of ordinary skill in the art is to be understood that, still can modify or be equal to replacement this utility model, to reach identical technique effect; Use needs as long as meet, all within protection domain of the present utility model.
Claims (9)
1. a large animal isolated working heart dual pathways perfusion experiment equipment, comprise anticoagulation closed circuit equipment and physiological solution closed circuit equipment, and the constant temperature system (1) being connected with physiological solution closed circuit equipment with anticoagulation closed circuit equipment, it is characterized in that: described anticoagulation closed circuit equipment comprises pulmonary artery pipe (14), pulmonary artery pipe (14) is connected with arteria coronaria pipe (6) with the first test instrunment (18), the artificial lung machine (19) with apparatus of oxygen supply (20), blood pump (17), coronary perfusion post (15) successively; Described physiological solution closed circuit equipment comprises initiatively vascular (4), and initiatively vascular (4) is connected with pulmonary vein pipe (3) with afterload post (13), the second tester (8) device, physiological solution pump (10), preload post (7) successively; Described constant temperature system (1) is connected with coronary perfusion post (15), afterload post (13) and preload post (7) respectively; Described constant temperature system (1) also comprises temperature chamber (2).
2. large animal isolated working heart dual pathways perfusion experiment equipment according to claim 1, is characterized in that: described coronary perfusion post (15) top is provided with the first limit for height reflux pipe (16) that same blood pump (17) entrance is communicated with; The top of described preload post (7) is provided with the second limit for height reflux pipe (11) that same physiological solution pump (10) entrance is communicated with.
3. large animal isolated working heart dual pathways perfusion experiment equipment according to claim 1, it is characterized in that: on described afterload post (13), vertically be placed with at least two afterload limit for height branch roads (12) that are communicated with the second tester (8) device, on each afterload limit for height branch road (12), be provided with open and close valve (9).
4. large animal isolated working heart dual pathways perfusion experiment equipment according to claim 1, it is characterized in that: described arteria coronaria pipe (6) is arranged in active vascular (4), and described active vascular (4) comprises the upper pipe (28) and the lower pipe (23) that connect by screw thread (26).
5. large animal isolated working heart dual pathways perfusion experiment equipment according to claim 4, it is characterized in that: the upper inner of described lower pipe (23) is provided with screw thread (26), described upper pipe (28) outer surface bottom and top are respectively arranged with screw thread (26).
6. large animal isolated working heart dual pathways perfusion experiment equipment according to claim 5, is characterized in that: the lower end of described upper pipe (28) is provided with the fixture block (24) that the same pipe (28) upper end coordinates.
7. large animal isolated working heart dual pathways perfusion experiment equipment according to claim 4, it is characterized in that: described arteria coronaria pipe (6) comprises the hard straight tube (25) being arranged in active vascular (4), the lower end of hard straight tube (25) is provided with two flexible pipes (22), two flexible pipes (22) end is provided with intubate head (21), is provided with the loop-like or helical form Os Draconis (27) of hard in described flexible pipe (22).
8. large animal isolated working heart dual pathways perfusion experiment equipment according to claim 7, is characterized in that: described flexible pipe (22) is made up of silica gel.
9. large animal isolated working heart dual pathways perfusion experiment equipment according to claim 1, it is characterized in that: described constant temperature system (1) comprises constant-temperature water circulating device, constant-temperature water circulating device is connected with being arranged at the outer thermostatic water-jacket (5) of coronary perfusion post (15), preload post (7) and afterload post (13).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420034355.8U CN203724222U (en) | 2014-01-20 | 2014-01-20 | Large animal in-vitro working heart double-channel perfusion experimental equipment |
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| CN201420034355.8U CN203724222U (en) | 2014-01-20 | 2014-01-20 | Large animal in-vitro working heart double-channel perfusion experimental equipment |
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| CN203724222U true CN203724222U (en) | 2014-07-23 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103750905A (en) * | 2014-01-20 | 2014-04-30 | 辽宁中医药大学 | Isolated working heart dual-channel perfusion experiment method and device for large animals |
| CN106998676A (en) * | 2014-12-12 | 2017-08-01 | D·弗里德 | Apparatus and method for organ perfusion |
| CN107156109A (en) * | 2017-05-31 | 2017-09-15 | 上海市杨浦区市东医院 | A kind of isolated organ preserves system |
| US11844345B2 (en) | 2005-06-28 | 2023-12-19 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| US11856944B2 (en) | 2011-04-14 | 2024-01-02 | Transmedics, Inc. | Organ care solution for ex-vivo machine perfusion of donor lungs |
| US11903381B2 (en) | 2014-06-02 | 2024-02-20 | Transmedics, Inc. | Ex vivo organ care system |
| US11917991B2 (en) | 2007-03-20 | 2024-03-05 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
| US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US12127554B2 (en) | 2023-08-11 | 2024-10-29 | Transmedics, Inc. | Apparatus and method for ex vivo lung ventilation with a varying exterior pressure |
-
2014
- 2014-01-20 CN CN201420034355.8U patent/CN203724222U/en not_active Expired - Lifetime
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US11844345B2 (en) | 2005-06-28 | 2023-12-19 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| US11917991B2 (en) | 2007-03-20 | 2024-03-05 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
| US11856944B2 (en) | 2011-04-14 | 2024-01-02 | Transmedics, Inc. | Organ care solution for ex-vivo machine perfusion of donor lungs |
| CN103750905B (en) * | 2014-01-20 | 2015-08-12 | 辽宁中医药大学 | Large animal isolated working heart dual pathways perfusion experiment method and apparatus |
| CN103750905A (en) * | 2014-01-20 | 2014-04-30 | 辽宁中医药大学 | Isolated working heart dual-channel perfusion experiment method and device for large animals |
| US11944088B2 (en) | 2014-06-02 | 2024-04-02 | Transmedics, Inc. | Ex vivo organ care system |
| US11903381B2 (en) | 2014-06-02 | 2024-02-20 | Transmedics, Inc. | Ex vivo organ care system |
| CN106998676B (en) * | 2014-12-12 | 2021-10-26 | 体沃索股份有限公司 | Apparatus and method for organ perfusion |
| US11963526B2 (en) | 2014-12-12 | 2024-04-23 | Transmedics, Inc. | Apparatus and method for organ perfusion |
| CN106998676A (en) * | 2014-12-12 | 2017-08-01 | D·弗里德 | Apparatus and method for organ perfusion |
| CN107156109A (en) * | 2017-05-31 | 2017-09-15 | 上海市杨浦区市东医院 | A kind of isolated organ preserves system |
| US12127554B2 (en) | 2023-08-11 | 2024-10-29 | Transmedics, Inc. | Apparatus and method for ex vivo lung ventilation with a varying exterior pressure |
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| GR01 | Patent grant | ||
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Granted publication date: 20140723 |