CN104825233B - Experimental device for frog heart perfusion - Google Patents
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- 230000010412 perfusion Effects 0.000 title claims abstract description 25
- 210000000709 aorta Anatomy 0.000 claims abstract description 5
- 238000002474 experimental method Methods 0.000 claims description 15
- 230000003139 buffering effect Effects 0.000 claims description 3
- 238000013139 quantization Methods 0.000 claims 4
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 210000003462 vein Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 7
- 239000007788 liquid Substances 0.000 abstract description 6
- 230000035479 physiological effects, processes and functions Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 5
- 230000008827 biological function Effects 0.000 description 4
- 238000011002 quantification Methods 0.000 description 4
- 230000004217 heart function Effects 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 238000007792 addition Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
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- 210000001367 artery Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 230000002182 neurohumoral effect Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 230000036316 preload Effects 0.000 description 1
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- 230000033764 rhythmic process Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
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- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
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Abstract
本发明涉及医学机能学、生理学实验装置，具体涉及一种蛙心灌流实验装置,包括顶部设置有开口的缓冲管、同所述缓冲管连接的三通缓冲动脉管、同所述三通缓冲动脉管的一个支管连接的动脉插头、同所述三通缓冲动脉管的另一支管连接的动脉插管、同所述动脉插管连接的量化滴装置、设置在所述量化滴装置下方的静脉插管、同所述静脉插管连接的静脉插头，所述动脉插头插入蛙心的主动脉上，所述静脉插头插入蛙心的后腔静脉上。本发明一种改进蛙心灌流实验装置，对蛙心射血过程中射出的灌注液起到缓冲作用，可保持灌注液不间断的滴状流出，在心脏收缩期和舒张期均有灌注液流出，通过量化滴装置能实现液体量化记录。
The present invention relates to medical functional science and physiology experimental equipment, in particular to a frog heart perfusion experimental equipment, comprising a buffer tube with an opening at the top, a three-way buffer arterial tube connected with the buffer tube, and a three-way buffer arterial tube connected with the three-way buffer arterial tube. An arterial plug connected to one branch of the tube, an arterial cannula connected to the other branch of the three-way buffer arterial tube, a quantitative drop device connected to the arterial cannula, a venous plug arranged below the quantitative drop device Tube, the venous plug connected with the venous cannula, the arterial plug is inserted into the aorta of the frog heart, and the venous plug is inserted into the posterior vena cava of the frog heart. The invention is an improved frog heart perfusion experimental device, which can buffer the perfusate injected during the frog heart ejection process, and can keep the perfusate dripping out continuously, and the perfusate flows out during the systole and diastole , liquid quantitative recording can be realized through the quantitative drop device.
Description
技术领域technical field
本发明涉及医学机能学、生理学实验装置，具体涉及一种蛙心灌流实验装置。The invention relates to a medical functional science and physiology experimental device, in particular to a frog heart perfusion experimental device.
背景技术Background technique
离体心脏灌流是研究心脏功能的重要手段之一，广泛应用于医学、生物学、药学等教学和科研工作中。采用离体心脏灌流系统可以直观地观察心脏的活动，研究心脏舒缩功能，心率和节律变化，前后负荷及各种体液因素等对心脏功能的影响。采用蛙心脏进行离体心脏灌流是较为常用的一种模型，因其稳定，经济，一直被人们广泛采用。进行离体心脏灌流实验，首先需要保证心脏在体外较长时间存活，然后根据实验目的进行灌流和施加实验因素。无论是心脏离体前的插管、血流冲洗等操作，还是心脏离体后用人工溶液代替血液进行灌流，均使心脏脱离了生理性神经体液环境。因此，使离体心脏较长时间存活，并维持良好的状态对于完成实验和取得可靠实验数据极为重要。Isolated heart perfusion is one of the important means of studying heart function, and it is widely used in teaching and scientific research in medicine, biology, and pharmacy. Using the isolated heart perfusion system can visually observe the activity of the heart, and study the effects of cardiac diastolic and systolic function, heart rate and rhythm changes, preload and postload, and various body fluid factors on cardiac function. The isolated heart perfusion using the frog heart is a more commonly used model, and it has been widely used because of its stability and economy. To conduct isolated heart perfusion experiments, first of all, it is necessary to ensure that the heart survives in vitro for a long time, and then perform perfusion and apply experimental factors according to the purpose of the experiment. Whether it is the operation of intubation, blood flow flushing before the heart is isolated, or the use of artificial solution instead of blood for perfusion after the heart is isolated, the heart is separated from the physiological neurohumoral environment. Therefore, it is very important to make the isolated heart survive for a long time and maintain a good condition to complete the experiment and obtain reliable experimental data.
传统实验装置中在心脏收缩期灌注液呈柱状射出，而舒张期因无压力无灌注液射出。原始装置无缓冲管，无法保证舒张期灌注液射出，收缩期则成柱状射出，不便于蛙心射出液体的量化。In the traditional experimental device, the perfusate is ejected in a columnar shape during systole, but there is no perfusate ejected during diastole due to no pressure. The original device has no buffer tube, which cannot guarantee the injection of the perfusate during the diastolic period, and the injection is columnar during the systolic period, which is not convenient for the quantification of the fluid injected by the frog heart.
发明内容Contents of the invention
本发明的目的之一是为解决无法保证舒张期灌注液射出，不便于蛙心射出液体的量化问题，提供一种蛙心灌流实验装置，对蛙心射血过程中射出的灌注液起到缓冲作用，可保持灌注液不间断的滴状流出，在心脏收缩期和舒张期均有灌注液流出，通过记滴装置能实现液体量化记录。One of the purposes of the present invention is to provide a frog heart perfusion experimental device to provide a buffer for the perfusate injected during the frog heart ejection process in order to solve the problem that the injection of perfusate during diastole cannot be guaranteed and it is inconvenient to quantify the liquid injected by the frog heart Function, it can keep the perfusate dripping out continuously, and the perfusate flows out during the systole and diastole, and the liquid quantitative recording can be realized through the drip recording device.
为了达到上述技术效果，本发明的技术方案包括：In order to achieve the above-mentioned technical effect, technical scheme of the present invention comprises:
一种改进蛙心灌流实验装置，包括动脉插头，动脉插管，同所述动脉插管连接的量化滴装置、设置在所述量化滴装置下方的静脉插管、同所述静脉插管连接的静脉插头，所述动脉插头插入蛙心的主动脉上，所述静脉插头插入蛙心的后腔静脉上，其特征在于，包括顶部设置有开口的缓冲管、同所述缓冲管连接的三通缓冲动脉管、三通缓冲动脉管的一个支管连接动脉插头、三通缓冲动脉管的另一支管连接动脉插管。An improved frog heart perfusion experimental device, comprising an arterial plug, an arterial cannula, a quantitative drop device connected to the arterial cannula, a venous cannula arranged below the quantitative drop device, and a venous cannula connected to the venous cannula Venous plug, the arterial plug is inserted into the aorta of the frog heart, and the venous plug is inserted into the posterior vena cava of the frog heart, it is characterized in that it includes a buffer tube with an opening at the top and a tee connected to the buffer tube The buffer arterial tube, one branch of the three-way buffer arterial tube is connected to the arterial plug, and the other branch of the three-way buffer arterial tube is connected to the arterial cannula.
所述量化滴装置包括记滴管、记滴电极和记滴引导线。The quantitative drop device includes a drop tube, a drop electrode and a drop guide wire.
所述量化滴装置记录方式为16滴计为1ml。The recording method of the quantitative drop device is that 16 drops are counted as 1 ml.
本发明有益效果包括：The beneficial effects of the present invention include:
1、本发明蛙心灌流实验装置，对蛙心射血过程中射出的灌注液起到缓冲作用，可保持灌注液不间断的滴状流出，在心脏收缩期和舒张期均有灌注液流出，通过量化滴装置能实现液体量化记录。1. The frog heart perfusion experimental device of the present invention can buffer the perfusate injected during the frog heart ejection process, and can keep the perfusate dripping out continuously, and the perfusate flows out during systole and diastole. Quantitative recording of liquid can be realized by quantitative drop device.
2、本发明蛙心灌流实验装置，可一定程度提高循环液体的温度，保持蛙心标本的活性。2. The frog heart perfusion experimental device of the present invention can increase the temperature of the circulating liquid to a certain extent and maintain the activity of the frog heart specimen.
3、本发明蛙心灌流实验装置，装置简单，容易操作，更准确的测量蛙心输出量、主动脉血量等生理学数据，提高了实验的准确率、成功率。3. The frog heart perfusion experiment device of the present invention is simple and easy to operate, and can more accurately measure physiological data such as frog heart output and aortic blood volume, improving the accuracy and success rate of the experiment.
附图说明Description of drawings
图1所示为本发明蛙心灌流实验装置示意图。FIG. 1 is a schematic diagram of a frog heart perfusion experimental device of the present invention.
图2所示为本发明蛙心灌流实验装置图1的A处局部放大图。Fig. 2 is a partially enlarged view of A in Fig. 1 of the frog heart perfusion experiment device of the present invention.
图示：1-缓冲管、2-三通缓冲动脉管、3-动脉插头、4-动脉插管、5-量化滴装置、51-记滴管、52-记滴电极、53-记滴引导线、6-静脉插管、7-静脉插头、8-生物机能实验系统。Illustration: 1-buffer tube, 2-tee buffer arterial tube, 3-arterial plug, 4-arterial cannula, 5-quantitative drop device, 51-drop tube, 52-drop electrode, 53-drop guide Line, 6-venous cannula, 7-venous plug, 8-biological function experiment system.
具体实施方式detailed description
下文将结合具体附图详细描述本发明具体实施例。应当注意的是，下述实施例中描述的技术特征或者技术特征的组合不应当被认为是孤立的，它们可以被相互组合从而达到更好的技术效果。在下述实施例的附图中，各附图所出现的相同标号代表相同的特征或者部件，可应用于不同实施例中。Specific embodiments of the present invention will be described in detail below in conjunction with specific drawings. It should be noted that the technical features or combinations of technical features described in the following embodiments should not be regarded as isolated, and they can be combined with each other to achieve better technical effects. In the drawings of the following embodiments, the same reference numerals appearing in each drawing represent the same features or components, which can be applied in different embodiments.
实施例：Example:
如图1所示本发明一种蛙心灌流实验装置示意图。一种蛙心灌流实验装置，包括顶部设置有开口的缓冲管1、同所述缓冲管1连接的三通缓冲动脉管2、同所述三通缓冲动脉管2的一个支管连接的动脉插头3、同所述三通缓冲动脉管2的另一支管连接的动脉插管4、同所述动脉插管4连接的量化滴装置5、设置在所述量化滴装置5下方的静脉插管6、同所述静脉插管6连接的静脉插头7，所述动脉插头3插入蛙心的主动脉上，所述静脉插头7插入蛙心的后腔静脉上。As shown in Figure 1, a schematic diagram of a frog heart perfusion experimental device of the present invention. A frog heart perfusion experimental device, comprising a buffer tube 1 with an opening at the top, a three-way buffer arterial tube 2 connected to the buffer tube 1, and an arterial plug 3 connected to a branch of the three-way buffer arterial tube 2 , an arterial cannula 4 connected to another branch of the three-way buffer arterial tube 2, a quantitative drop device 5 connected to the arterial cannula 4, a venous cannula 6 arranged below the quantitative drop device 5, The venous plug 7 connected with the venous cannula 6, the arterial plug 3 is inserted into the aorta of the frog heart, and the venous plug 7 is inserted into the posterior vena cava of the frog heart.
如图2所示，所述量化滴装置5包括记滴管51、记滴电极52和记滴引导线53。As shown in FIG. 2 , the quantitative drop device 5 includes a drop tube 51 , a drop electrode 52 and a drop guide wire 53 .
所述量化滴装置5记录方式为16滴计为1ml。The recording method of the quantitative drop device 5 is that 16 drops are counted as 1 ml.
准备灌流实验时，连接好实验装置，用探针破坏蛙脊髓和大脑，仰卧位固定在蛙板上。打开胸腔暴露蛙心，剪开心包膜，先在装置的缓冲管1中装满任氏液，把装置中的动脉插管3插入蛙主动脉内，用线固定结扎；将蛙心向上翻，暴露出腔静脉，将装置中的静脉插管6插入腔静脉中结扎固定。用手术剪剪断血管，将蛙心从胸腔内提出，固定在万用支架上。将本发明的实验装置同生物机能实验系统8连接。在装置中有记滴用的量化滴装置5。量化滴装置5由记滴管51、记滴电极52和记滴引导线53组成。量化滴装置5安放在静脉插管6的正上方。量化滴装置5通过记滴电极52和记滴引导线53连接生物机能实验系统8，生物机能实验系统8同电脑相连接，当有液滴滴落时，通过记滴电极52感应，并将感应信号传递到生物机能实验系统8，便可在电脑上记下，从而可以测定蛙心输出量实现量化作用。When preparing for the perfusion experiment, connect the experimental device, use a probe to destroy the frog spinal cord and brain, and fix it on the frog board in the supine position. Open the chest cavity to expose the frog heart, cut the pericardium, first fill the buffer tube 1 of the device with Ren's solution, insert the arterial cannula 3 in the device into the frog's aorta, fix and ligate it with a thread; turn the frog heart upwards, The vena cava is exposed, and the venous cannula 6 in the device is inserted into the vena cava and ligated and fixed. Use surgical scissors to cut off the blood vessels, lift the frog heart out of the thorax, and fix it on a universal stent. The experimental device of the present invention is connected with the biological function experimental system 8 . There is the quantification drop device 5 that records drop usefulness in the device. The quantitative drop device 5 is composed of a drop tube 51 , a drop electrode 52 and a drop guide wire 53 . The quantitative drop device 5 is placed directly above the venous cannula 6 . The quantification drop device 5 is connected to the biological function experiment system 8 by the drop recording electrode 52 and the drop recording guide line 53, and the biological function experiment system 8 is connected with the computer. The signal is transmitted to the biological function experiment system 8, and then it can be recorded on the computer, so that the frog heart output can be measured to realize quantification.
缓冲管1以缓冲和能量转换为主，在缓冲管1中加入灌输液。缓冲管1连通三通缓冲动脉管2，所述三通缓冲动脉管2的一个支管连接动脉插头3、所述三通缓冲动脉管2的另一支管连接动脉插管4，动脉插头3插入主动脉后，三通缓冲动脉管2经三通分流，使灌注液一部分进入动脉插头3，另一部分经动脉插管4进入量化滴装置5，经量化滴装置5进行量化记录，记16滴为1ml，进而灌注液经静脉插管6到静脉插头7回心。形成一个体外循环的在体蛙心灌流装置。The buffer tube 1 is mainly used for buffering and energy conversion, and the infusion fluid is added into the buffer tube 1 . The buffer tube 1 communicates with the three-way buffer arterial tube 2, one branch of the three-way buffer arterial tube 2 is connected to the arterial plug 3, the other branch of the three-way buffer arterial tube 2 is connected to the arterial cannula 4, and the arterial plug 3 is inserted into the main After the artery, the three-way buffer arterial tube 2 is shunted through the three-way, so that part of the perfusate enters the arterial plug 3, and the other part enters the quantitative drop device 5 through the arterial cannula 4, and is quantified and recorded by the quantitative drop device 5, recording 16 drops as 1ml , and then the perfusate returns to the heart through the venous cannula 6 to the venous plug 7 . An in vivo frog heart perfusion device for extracorporeal circulation was formed.
本发明一种蛙心灌流实验装置，对蛙心射血过程中射出的灌注液起到缓冲作用，可保持灌注液不间断的滴状流出，在心脏收缩期和舒张期均有灌注液流出，通过量化滴装置能实现液体量化记录。The frog heart perfusion experiment device of the present invention can buffer the perfusate injected during the process of frog heart ejection, and can keep the perfusate dripping out continuously, and the perfusate flows out during systole and diastole Quantitative recording of liquid can be realized by quantitative drop device.
上述详细说明是针对发明的可行实施例的具体说明，该实施例并非用以限制本发明的专利范围，凡未脱离本发明的等效实施或变更，均应当包含于本发明的专利范围内。The above detailed description is a specific description of a feasible embodiment of the invention. This embodiment is not intended to limit the patent scope of the present invention. Any equivalent implementation or change that does not deviate from the present invention shall be included in the patent scope of the present invention.
另外，本领域技术人员还可在本发明权利要求公开的范围和精神内做其它形式和细节上的各种修改、添加和替换。当然，这些依据本发明精神所做的各种修改、添加和替换等变化，都应包含在本发明所要求保护的范围之内。In addition, those skilled in the art can also make various modifications, additions and substitutions in other forms and details within the scope and spirit disclosed in the claims of the present invention. Certainly, the various modifications, additions, substitutions and other changes made according to the spirit of the present invention shall all be included within the scope of protection claimed by the present invention.
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| CN108196042A (en) * | 2018-03-16 | 2018-06-22 | 延边大学 | Amphibian Perfused isolated heart device |
| CN110320351A (en) * | 2019-08-21 | 2019-10-11 | 延边大学 | Isolated frog heart perfusion experiment instructional device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459977A (en) * | 1981-03-27 | 1984-07-17 | Veronique Pizon | Coronary sinus retroperfusion apparatus for the treatment of myocardial ischemia |
| US5687718A (en) * | 1994-07-09 | 1997-11-18 | Hewlett-Packard Company | Device for continuously detecting blood parameters |
| CN2582078Y (en) * | 2002-08-28 | 2003-10-22 | 王庆山 | Apparatus for counting drops of in vitro frog heart perfusion |
| CN201293783Y (en) * | 2008-10-13 | 2009-08-19 | 武汉大学 | Device for circulation and perfusion of in-vitro heart of laboratory animal |
| CN201441461U (en) * | 2009-07-10 | 2010-04-28 | 泰山学院 | A New Frog Heart Perfusion Experimental Device |
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2015
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459977A (en) * | 1981-03-27 | 1984-07-17 | Veronique Pizon | Coronary sinus retroperfusion apparatus for the treatment of myocardial ischemia |
| US5687718A (en) * | 1994-07-09 | 1997-11-18 | Hewlett-Packard Company | Device for continuously detecting blood parameters |
| CN2582078Y (en) * | 2002-08-28 | 2003-10-22 | 王庆山 | Apparatus for counting drops of in vitro frog heart perfusion |
| CN201293783Y (en) * | 2008-10-13 | 2009-08-19 | 武汉大学 | Device for circulation and perfusion of in-vitro heart of laboratory animal |
| CN201441461U (en) * | 2009-07-10 | 2010-04-28 | 泰山学院 | A New Frog Heart Perfusion Experimental Device |
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