CN203414459U - Isolated heart perfusion device - Google Patents
Isolated heart perfusion device Download PDFInfo
- Publication number
- CN203414459U CN203414459U CN201320523290.9U CN201320523290U CN203414459U CN 203414459 U CN203414459 U CN 203414459U CN 201320523290 U CN201320523290 U CN 201320523290U CN 203414459 U CN203414459 U CN 203414459U
- Authority
- CN
- China
- Prior art keywords
- constant voltage
- perfusion device
- oxygenator
- isolated heart
- overflow cup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The utility model discloses an isolated heart perfusion device. The isolated heart perfusion device comprises a bottom frame, a constant temperature water tank, a supporting platform and a plurality of blood vessel intubation tubes, wherein the supporting platform is movably arranged on the bottom frame; a first peristaltic pump, a second peristaltic pump and a liquid storage tank are mounted on a base plate of the bottom frame; a first constant pressure overflowing cup and a first oxygenator are respectively and movably arranged on a right-side longitudinal beam of the bottom frame from bottom to top, and a second constant pressure overflowing cup and a second oxygenator are respectively and movably arranged on a left-side longitudinal beam of the bottom frame from bottom to top. According to the isolated heart perfusion device, working conditions for testing isolated hearts of large mammals can be completely met, and the problems of myocardial ischemia, oxygen deficit, arrhythmia and the like of cardiac muscles of the isolated hearts, caused due to instability of components such as electrolytes and oxygen, are effectively avoided; compared with relevant foreign perfusion facilities, the isolated heart perfusion device has the advantages of simple structure, low cost, convenience in operation, popularization and use and the like.
Description
Technical field
The utility model relates to Medical Instruments technical field, be specifically related to a kind of for drugs the isolated heart perfusion device on isolated heart function impact, visual analyzing cardiac function anatomical structure and separating myocardium cell.
Background technology
Isolated heart model based on meiofauna, differs larger with human heart physiological structure, can not meet gradually clinical research worker's needs.Large mammal man pig, beasle dog etc. are closely similar with size, anatomical structure, the Electrophysiological characteristics of normal adult human heart solution heart.Large mammal isolated heart working model has broad application prospects in the systematization of anatomical cardiac, function and electrophysiological mechanism, visual, industrialization.Heart is all very complicated organs of a structure and motion, and further investigation heartbeat mechanism is understood anatomical structure, electric physiology and the mechanical characteristic of heart, for the prevention of heart disease with treat of crucial importance.But the perfusion apparatus expensive of current existing large mammal isolated heart four chamber heart working models, large and the complicated operation of technical difficulty, and in worldwide, still do not have at present complete large-scale mammal isolated heart perfusion equipment to sell, limited it and applied.
Utility model content
For above-mentioned deficiency of the prior art, the utility model provides a kind of cost isolated heart perfusion device low, simple to operate.
In order to reach foregoing invention object, the technical solution adopted in the utility model is: a kind of isolated heart perfusion device is provided, it comprises underframe, constant temperature water tank, is movably arranged on support platform and some vascular catheterizations on underframe, and the first peristaltic pump, the second peristaltic pump and liquid storage tank are installed on the base plate of described underframe; The right-hand stringer of underframe is movably set with respectively the first constant voltage overflow cup and the first oxygenator from the bottom to top, and the left-hand stringer of underframe is movably set with respectively the second constant voltage overflow cup and the second oxygenator from the bottom to top.
Described liquid storage tank, the first peristaltic pump, the first oxygenator and the first constant voltage overflow cup are connected in turn by conduit; Described liquid storage tank, the second peristaltic pump, the second oxygenator and the second constant voltage overflow cup are connected in turn by conduit; Described constant temperature water tank water delivering orifice and water inlet are respectively provided with three water service pipes, and two three water service pipes are connected with the second oxygenator with the first oxygenator respectively.
Further, on described underframe, by dismountable clip, be also provided with endoscope, ultrasonic probe and video camera.
Further, on described underframe, be provided with and be convenient to the deflecting roller that it moves.
Further, described vascular catheterization one end mouth of pipe is hexagon or circular projection, to realize the effect of fixing and prevent fast slippage.
Further, described vascular catheterization one end mouth of pipe is hexagon or circular projection.
Further, described the first constant voltage overflow cup and the second constant voltage overflow cup are respectively provided with a water delivering orifice in bottom and middle part, and water inlet is arranged on the top of middle part water delivering orifice, between cup middle part water delivering orifice and water inlet, are provided with screen pack.
Further, the diameter of described conduit is 8mm-10mm.
Further, the vertical interval between two outlets of the first constant voltage overflow cup and the second constant voltage overflow cup is 3cm-5cm; Middle part water delivering orifice and the vertical interval between diapire of the first constant voltage overflow cup and the second constant voltage overflow cup are 5cm-8cm.
The beneficial effects of the utility model are: this isolated heart perfusion device can meet the condition of work that large mammal isolated heart is tested completely, effectively avoided isolated heart cardiac muscle because of problems such as the unstable myocardial ischemia causing of the compositions such as electrolyte, oxygen, anoxic and arrhythmia cordis, compare to external relevant perfusion equipment have simple in structure, expense is cheap, the advantage such as easy to operate, is convenient to promote the use of.
Accompanying drawing explanation
Fig. 1 is the front view of isolated heart perfusion device;
Fig. 2 is the vertical view of isolated heart perfusion device.
Wherein, the 1, first peristaltic pump; 2, underframe; 21, deflecting roller; 22, right-hand stringer; 23, left-hand stringer; 3, support platform; 4, the first constant voltage overflow cup; 5, the first oxygenator; 6, the second oxygenator; 7, the second constant voltage overflow cup; 8, the second peristaltic pump; 9, liquid storage tank.
Embodiment
As depicted in figs. 1 and 2, this isolated heart perfusion device comprises underframe 2, constant temperature water tank, is movably arranged on support platform 3 and some vascular catheterizations on underframe 2, and the first peristaltic pump 1, the second peristaltic pump 8 and liquid storage tank 9 are installed on the base plate of described underframe 2; The right-hand stringer 22 of underframe 2 is movably set with respectively the first constant voltage overflow cup 4 and the first oxygenator 5 from the bottom to top, and the left-hand stringer 23 of underframe 2 is movably set with respectively the second constant voltage overflow cup 7 and the second oxygenator 6 from the bottom to top; Described constant temperature water tank water inlet and water delivering orifice are respectively provided with three water service pipes.
On described underframe 2, also by dismountable clip fixed endoscope, ultrasonic probe and video camera etc., detect finder.In order to facilitate the movement of this perfusion device, on underframe 2, be provided with and be convenient to its deflecting roller moving 21.
According to the preload of left and right ventricles system, the entrance of the first constant voltage overflow cup 4 and the second constant voltage overflow cup 7 is arranged on top, the first constant voltage overflow cup 4 is in its bottom and respectively offer a water delivering orifice apart from 8cm place, bottom, the second constant voltage overflow cup 7 is in its bottom and respectively offer a water delivering orifice apart from 5cm place, bottom, insert and A/C, to ensure that liquid level is no more than water delivering orifice position, middle part, the effect of playing constant voltage is (different according to the pressure in physiological conditions left atrium, so connecting right room is connected with the second constant voltage overflow cup 7, left room is connected with the first constant voltage overflow cup 4), simultaneously, the first constant voltage overflow cup 4 and the second constant voltage overflow cup 7 are provided with screen pack between middle part water delivering orifice and water inlet, play filtering function, to prevent bubble, big particle enters coronary artery system.In order effectively to control liquid level, the diameter of the conduit that perforate is implanted is arranged to 8mm-10mm, is not less than the diameter of inlet connection.
During test, first liquid storage tank 9, the first peristaltic pump 1, the first oxygenator 5 are connected by conduit in turn with the first constant voltage overflow cup 4; Liquid storage tank 9, the second peristaltic pump 8, the second oxygenator 6 are connected by conduit in turn with the second constant voltage overflow cup 7; Two three water service pipes of constant temperature water tank are connected with the second oxygenator 6 with the first oxygenator 5 respectively, on the first constant voltage overflow cup 4, the second constant voltage overflow cup 7, respectively connect a vascular catheterization, on liquid storage tank 9, fix two vascular catheterizations, the loose one end of vascular catheterization mouth of pipe is hexagon or circular projection after polishing; Then in liquid storage tank 9, pour into crystalloid fluid; Isolated heart is placed on to support platform 3 positions, and the mouth of pipe that vertical centrifugal dirty blood vessel is to hexagon or circular projection with vascular catheterization polishing is respectively connected; Start the first peristaltic pump 1, the second peristaltic pump 8, to the first oxygenator 5 and the second oxygenator 6, pump into crystalloid fluid; Crystalloid fluid closes after (access carbon dioxide) through heating, deoxidation at the first oxygenator 5 heating, oxygenate (access oxygen) and the second oxygenator 6, drives in the wrong direction and enters the sustainer of isolated heart, arrives coronary artery system, recovers cardiac muscle active; After cardiac muscle activity recovery, recover gradually volume load and the pressure load of left and right ventricles system.In whole process of the test, constant temperature water tank heats entering the water of the first oxygenator 5 and the second oxygenator 6, and the coolant-temperature gage in constant temperature water tank is 37 ℃, guarantees that crystal perfusate is stabilized in 36.9 degrees Celsius of left and right.
Although by reference to the accompanying drawings embodiment of the present utility model is described in detail, should not be construed as the restriction to the protection domain of this patent.In the described scope of claims, the various modifications that those skilled in the art can make without creative work and distortion still belong to the protection domain of this patent.
Claims (7)
1. an isolated heart perfusion device, it is characterized in that: comprise underframe, constant temperature water tank, be movably arranged on support platform and some vascular catheterizations on underframe, the first peristaltic pump, the second peristaltic pump, liquid storage tank and constant temperature water tank are installed on the base plate of described underframe; The right-hand stringer of underframe is movably set with respectively the first constant voltage overflow cup and the first oxygenator from the bottom to top, and the left-hand stringer of underframe is movably set with respectively the second constant voltage overflow cup and the second oxygenator from the bottom to top;
Described liquid storage tank, the first peristaltic pump, the first oxygenator and the first constant voltage overflow cup are connected in turn by conduit; Described liquid storage tank, the second peristaltic pump, the second oxygenator and the second constant voltage overflow cup are connected in turn by conduit; Described constant temperature water tank water delivering orifice and water inlet are respectively provided with three water service pipes, and two three water service pipes are connected with the second oxygenator with the first oxygenator respectively.
2. isolated heart perfusion device according to claim 1, is characterized in that: on described underframe, by dismountable clip, be also provided with endoscope, ultrasonic probe and video camera.
3. isolated heart perfusion device according to claim 1, is characterized in that: on described underframe, be provided with and be convenient to the deflecting roller that it moves.
4. isolated heart perfusion device according to claim 1, is characterized in that: described vascular catheterization one end mouth of pipe is hexagon or circular projection.
5. according to the arbitrary described isolated heart perfusion device of claim 1-4, it is characterized in that: described the first constant voltage overflow cup and the second constant voltage overflow cup are respectively provided with a water delivering orifice in bottom and middle part, water inlet is arranged on the top of middle part water delivering orifice, between cup middle part water delivering orifice and water inlet, is provided with screen pack.
6. according to the arbitrary described isolated heart perfusion device of claim 1-4, it is characterized in that: the diameter of described conduit is 8mm-10mm.
7. isolated heart perfusion device according to claim 5, is characterized in that: the vertical interval between two outlets of the first constant voltage overflow cup and the second constant voltage overflow cup is 3cm-5cm; Middle part water delivering orifice and the vertical interval between diapire of the first constant voltage overflow cup and the second constant voltage overflow cup are 5cm-8cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320523290.9U CN203414459U (en) | 2013-08-27 | 2013-08-27 | Isolated heart perfusion device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320523290.9U CN203414459U (en) | 2013-08-27 | 2013-08-27 | Isolated heart perfusion device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203414459U true CN203414459U (en) | 2014-01-29 |
Family
ID=49977341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320523290.9U Expired - Lifetime CN203414459U (en) | 2013-08-27 | 2013-08-27 | Isolated heart perfusion device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203414459U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108717112A (en) * | 2018-06-08 | 2018-10-30 | 新乡医学院 | A kind of Perfused isolated heart device suitable for rat |
| CN109526944A (en) * | 2019-01-07 | 2019-03-29 | 成都泰盟软件有限公司 | A kind of exhaust bubble structure in Perfused isolated heart system |
-
2013
- 2013-08-27 CN CN201320523290.9U patent/CN203414459U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108717112A (en) * | 2018-06-08 | 2018-10-30 | 新乡医学院 | A kind of Perfused isolated heart device suitable for rat |
| CN108717112B (en) * | 2018-06-08 | 2019-08-30 | 新乡医学院 | A kind of Perfused isolated heart device suitable for rat |
| CN109526944A (en) * | 2019-01-07 | 2019-03-29 | 成都泰盟软件有限公司 | A kind of exhaust bubble structure in Perfused isolated heart system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Aslam et al. | Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease | |
| WO2020192513A1 (en) | Mechanical perfusion preservation device for living body's organs | |
| CN203724222U (en) | Large animal in-vitro working heart double-channel perfusion experimental equipment | |
| CN103750905B (en) | Large animal isolated working heart dual pathways perfusion experiment method and apparatus | |
| CN204606599U (en) | Stem cell carrying case | |
| WO2014200661A1 (en) | Heart-lung preparation and method of use | |
| CN203414459U (en) | Isolated heart perfusion device | |
| CN210749641U (en) | Animal head fixing device | |
| CN108196042A (en) | Amphibian Perfused isolated heart device | |
| CN210784410U (en) | Novel ultrasonic imaging department is with radiography display device | |
| CN209303312U (en) | A kind of Multifunction washing frame | |
| CN104825233B (en) | Experimental device for frog heart perfusion | |
| CN212212494U (en) | Normal-temperature mechanical perfusion device for isolated rat liver | |
| CN202093724U (en) | Training simulator for cerebral aneurysm embolization | |
| CN105559827B (en) | Device for fixing mouse body in ultrasonic examination | |
| CN204428192U (en) | A kind of postoperative zoopery framework | |
| CN207803317U (en) | A kind of constant current mouse liver ex vivo perfusion system | |
| CN207887209U (en) | A kind of clinical laboratory's sample storage rack | |
| CN210301068U (en) | Clinical laboratory is with adopting urine verifying attachment | |
| CN215606546U (en) | Injection and in vivo detection device for chicken embryo model and VDAs efficacy research | |
| CN210990278U (en) | Low-noise electrode device for recording in-vitro electrocardiogram | |
| CN218572359U (en) | Device that laboratory mouse instiled | |
| CN212035659U (en) | Rat liver normal atmospheric temperature machinery fills machine | |
| CN218386521U (en) | Electrocardiogram lead wire distribution frame | |
| CN217835469U (en) | Medical treatment operation car |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140129 |