CN210749641U - Animal head fixing device - Google Patents
Animal head fixing device Download PDFInfo
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- CN210749641U CN210749641U CN201920675574.7U CN201920675574U CN210749641U CN 210749641 U CN210749641 U CN 210749641U CN 201920675574 U CN201920675574 U CN 201920675574U CN 210749641 U CN210749641 U CN 210749641U
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- animal
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- fixed
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Abstract
The utility model discloses a fixing device for animal head, which comprises a hollow base and a supporting frame arranged on the base, wherein the top end of the base is provided with a containing groove which is formed by sinking downwards and is used for placing animal cages, the bottom end of the containing groove is provided with a plurality of gas outlets communicated with the inner cavity of the base, and the side wall of the base is provided with a gas inlet used for injecting gas into the inner cavity of the base; the middle part of support frame is provided with the vertical slide bar with animal cage utensil mutual disposition, the bottom of vertical slide bar is provided with the anchor clamps subassembly that is used for fixed animal head. The utility model discloses can realize the fixed of animal head, can guarantee animal health four limbs free movement simultaneously, reduce anesthesia and constraint to the influence of experimental result.
Description
Technical Field
The utility model relates to a fixing device, concretely relates to fixing device of animal head.
Background
In recent years, many advanced research methods such as in vivo two-photon imaging, optogenetics, microdialysis, electroencephalogram detection, in vivo electrophysiology, Positron Emission Tomography (PET), laser speckle cerebral blood flow imaging, etc., which play an important role in neuroscience research, have been developed in the field of neuroscience. However, in most of the experiments at present, the animals are under anesthesia. Anesthesia affects the basic function of the animal brain and these experimental results do not reflect the true physiological condition. For example, in a waking state, the clearance capacity of the brain of the mouse to the metabolites is obviously reduced compared with that in an anesthetic state; the cerebral cortex discharge activity of the rat is obviously inhibited under isoflurane anesthesia. With the development of brain science, the research on the pathology and physiology of animals in a waking state is required, and the research on the brain activity of animals under different behavior conditions is further required. Although there are many animal fixing devices such as big mouse fixer, stereotaxic apparatus, balance arm with swivel, etc., these apparatuses have their respective disadvantages, especially the experiments such as two-photon imaging and the like can not be carried out under the waking state.
Currently, there are many small animal fixation devices on the market: (1) the front end of the fixator is a movable conical head, the rear end of the fixator is a baffle, the baffle at the rear end is moved according to the size of an animal to fix the animal in the fixator, tail vein injection and blood sampling can be performed, the tail sleeve method is used for measuring blood pressure in a non-invasive manner, and the like, but the skull cannot be exposed and fixed, so that experiments such as in-vivo two-photon, microdialysis, laser speckle, electroencephalogram detection and the like cannot be performed; (2) the stereotaxic apparatus is the most commonly used animal skull fixer at present, can carry out brain stereotaxic injection, catheterization and the like, can carry out in-vivo two-photon imaging experiments after skull window operation, but the animals are in an anesthetic state; (3) the mouse balance arm is usually used for microdialysis and optogenetics experiments, the head of a mouse can move freely by being connected with the balance arm, but the head cannot be fixed, so that in-vivo two-photon imaging, PET imaging and the like cannot be carried out; (4) the head fixing device for the mouse to move on the running machine can fix the head of the mouse for in-vivo electrophysiological recording, a rotating wheel is arranged below the head fixing device, the mouse can run or walk above the head fixing device, but the head fixing device is large in size and not suitable for two-photon in-vivo imaging. With the development of brain science, the demand for devices for fixing the head while keeping the animal awake is increasing, and therefore, there is an urgent need for a fixing device which can fix the head of the animal and can freely move the body of the animal.
Disclosure of Invention
An object of the utility model is to overcome the not enough of above-mentioned background art, provide a fixing device of animal head, this fixing device can realize the fixed of animal head, can guarantee animal health four limbs free activity simultaneously, reduces anesthesia and constraint to the influence of experimental result.
In order to achieve the purpose, the utility model provides a fixing device for animal head, which comprises a hollow base and a support frame arranged on the base, wherein the top end of the base is provided with a containing groove which is formed by sinking downwards and is used for placing animal cages, the bottom end of the containing groove is provided with a plurality of gas outlets communicated with the inner cavity of the base, and the side wall of the base is provided with a gas inlet used for injecting gas into the inner cavity of the base; the middle part of support frame is provided with the vertical slide bar with animal cage utensil mutual disposition, the bottom of vertical slide bar is provided with the anchor clamps subassembly that is used for fixed animal head.
Further, the clamp assembly comprises a bottom plate, a cover plate and a fixing plate, the top end face of the bottom plate is fixedly connected with the bottom end face of the vertical sliding rod, the cover plate is arranged on the bottom plate and is fixedly connected with the bottom plate through a first screw, and the fixing plate is arranged between the bottom plate and the cover plate and is clamped and fixed through the bottom plate and the cover plate.
Furthermore, an observation hole is formed in the middle of the fixing plate, lightening holes are formed in two ends of the fixing plate, and the bottom end of the fixing plate is used for being bonded with the head of an animal.
Further, the bottom plate and the cover plate are provided with U-shaped holes which are oppositely arranged; the bottom plate and the cover plate are also provided with a plurality of oppositely arranged screw holes.
Further, the both sides of base all are provided with the mounting panel that is used for erection bracing frame, the mounting panel is with the both sides lateral wall fixed connection of base.
Further, the support frame includes the horizontal pole and sets up the montant at the horizontal pole both ends, the top and the horizontal pole fixed connection of montant, the bottom and the mounting panel fixed connection of montant.
Further, the bottom of montant is provided with the backing plate, the backing plate passes through second screw and mounting panel fixed connection.
Furthermore, the middle part of horizontal pole is provided with and is used for supplying the vertical slide bar to run through the mounting hole that passes through, vertical slide bar can slide from top to bottom in the mounting hole and pass through the third screw fixed with the horizontal pole.
Still further, the animal cage is a circular barrel-shaped structure, the top end of the animal cage is provided with an opening, and the bottom end of the animal cage is a closed surface.
Furthermore, the opening of the accommodating groove is circular or polygonal.
Compared with the prior art, the utility model has the advantages of as follows:
one of which, the utility model discloses a base design has air inlet and gas outlet, through ventilating in to the base and upwards discharge gas, the combustion gas upwards pushes up the animal cage utensil for frictional force between animal cage utensil and the base reduces greatly, and the small animal health four limbs of being convenient for remove, reduce anesthesia and constraint to the influence of experimental result.
And secondly, the utility model discloses an anchor clamps subassembly includes bottom plate, apron and fixed plate, and the fixed plate is fixed with the animal head, and it is fixed through both centre grippings between bottom plate and the apron to put into at the both ends of fixed plate, and last bottom plate passes through first screw fixation with the apron, and convenient operation, flexibility are high.
Thirdly, the utility model discloses a middle part of fixed plate is provided with the observation hole, and the both ends of fixed plate all are provided with the lightening hole, observe and operate when can be used for the staff experiment through observing the hole, like two photon formation of image, laser speckle cerebral blood flow formation of image, at body membrane pincers etc. can alleviate the weight of fixed plate through setting up the lightening hole.
Fourthly, the device of the utility model has the advantages of simple structure, small volume and strong practicability, and is applicable to various experimental methods.
Drawings
FIG. 1 is a schematic view of a device for securing an animal's head;
FIG. 2 is a rear view of the animal head restraint apparatus shown in FIG. 1;
FIG. 3 is a schematic cross-sectional view of the base;
FIG. 4 is a schematic top view of the cross bar;
FIG. 5 is a schematic top view of the base plate;
FIG. 6 is a schematic top view of the cover plate;
FIG. 7 is a schematic top view of the fixing plate;
FIG. 8 is a schematic view of the structure of the fixing plate mounted on the base plate;
in the figure: base 1, support frame 2 (horizontal pole 2.1, montant 2.2, backing plate 2.3, mounting hole 2.4), animal cage 3, storage tank 4, gas outlet 5, air inlet 6, vertical slide bar 7, anchor clamps subassembly 8 (bottom plate 8.1, apron 8.2, fixed plate 8.3, observation hole 8.31, lightening hole 8.32, U-shaped hole 8.4, screw 8.5), first screw 9.1, second screw 9.2, third screw 9.3, mounting panel 10.
Detailed Description
The following detailed description will be given with reference to the embodiments, but they are not intended to limit the present invention, and are given by way of example only. While the advantages of the invention will be apparent and readily appreciated by the description.
As shown in fig. 1, the fixing device for the head of an animal comprises a hollow base 1 and a support frame 2 arranged on the base 1, wherein a gas inlet 6 for injecting gas into an inner cavity of the base 1 is arranged on a side wall of the base 1, and when an experiment is carried out, the gas inlet 6 is connected with an external gas storage tank. As shown in fig. 3, the top end of the base 1 is provided with a receiving groove 4 formed by being recessed downwards for placing the animal cage 3, and the opening shape of the receiving groove 4 is circular or polygonal. Preferably, the opening of the receiving groove 4 is circular, and has a depth of 1 cm and a diameter of 30 cm. The bottom of the containing groove 4 is provided with a plurality of gas outlets 5 communicated with the inner cavity of the base 1, and the gas inlets 6 can discharge gas upwards through the gas outlets 5 after ventilation. The middle part of the support frame 2 is provided with a vertical slide bar 7 which is arranged opposite to the animal cage 3, and the bottom end of the vertical slide bar 7 is provided with a clamp component 8 for fixing the head of an animal. The animal cage 3 is a round barrel-shaped structure made of light plastic materials, the top end of the animal cage 3 is provided with an opening, the bottom end of the animal cage 3 is a closed surface, the animal cage 3 can be in a suspension state due to the air blown from the base 1, so that the friction force between the base 1 and the animal cage 3 is extremely small, and the four limbs of the body of an animal can freely move in the animal cage 3.
As shown in fig. 2, both sides of the base 1 are provided with mounting plates 10 for mounting the support frame 2, and the mounting plates 10 are fixedly connected with the side walls of both sides of the base 1. Support frame 2 is made by the metal material, including horizontal pole 2.1 and the montant 2.2 of setting at horizontal pole 2.1 both ends, montant 2.2's top and horizontal pole 2.1 fixed connection, montant 2.2's bottom and mounting panel 10 fixed connection. The bottom of montant 2.2 is provided with backing plate 2.3, and backing plate 2.3 passes through second screw 9.2 and mounting panel 10 fixed connection. As shown in fig. 4, the middle part of the cross bar 2.1 is provided with a mounting hole 2.4 for the vertical sliding rod 7 to pass through, the vertical sliding rod 7 can be adjusted to slide up and down in the mounting hole 2.4 according to different sizes of animals or different experimental requirements, and the vertical sliding rod 7 and the cross bar 2.1 are fixed through a third screw 9.3 after being adjusted.
As shown in fig. 5 and 6, the clamp assembly 8 includes a bottom plate 8.1, a cover plate 8.2, and a fixing plate 8.3, wherein a top end surface of the bottom plate 8.1 is fixedly connected to a bottom end surface of the vertical sliding rod 7, the cover plate 8.2 is disposed on the bottom plate 8.1 and is fixedly connected thereto by a first screw 9.1, and the fixing plate 8.3 is disposed between the bottom plate 8.1 and the cover plate 8.2 and is clamped and fixed by the two. The bottom plate 8.1 and the cover plate 8.2 are provided with U-shaped holes 8.4 which are oppositely arranged; the bottom plate 8.1 and the cover plate 8.2 are also provided with a plurality of oppositely arranged screw holes 8.5.
As shown in fig. 7 and 8, the middle of the fixing plate 8.3 is provided with an observation hole 8.31, when the fixing plate is installed, the observation hole 8.31 is installed on the U-shaped hole 8.4, and observation and operation of workers in experiments, such as two-photon imaging, laser speckle cerebral blood flow imaging, body membrane forceps and the like, are facilitated through the observation hole 8.31, and the size of the opening of the observation hole 8.31 is different according to different experiment requirements and animal sizes; the two ends of the fixing plate 8.3 are provided with lightening holes 8.32, so that the weight of the fixing plate 8.3 can be reduced, the bottom end of the fixing plate 8.3 is fixed on the skull of the head of an animal through dental cement bonding, the two ends of the fixing plate 8.3 are placed between the bottom plate 8.1 and the cover plate 8.2 and clamped and fixed through the bottom plate 8.1 and the cover plate 8.2, and finally the bottom plate 8.1 and the cover plate 8.2 are fixed through first screws 9.1.
While the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made by one skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. A fixing device of animal head, its characterized in that: the animal cage device comprises a hollow base (1) and a support frame (2) arranged on the base (1), wherein a containing groove (4) which is formed by sinking downwards and is used for containing an animal cage (3) is formed in the top end of the base (1), a plurality of air outlets (5) communicated with the inner cavity of the base (1) are formed in the bottom end of the containing groove (4), and an air inlet (6) used for injecting air into the inner cavity of the base (1) is formed in the side wall of the base (1); the animal head fixing device is characterized in that a vertical sliding rod (7) which is arranged opposite to the animal cage (3) is arranged in the middle of the supporting frame (2), and a clamp assembly (8) used for fixing the head of an animal is arranged at the bottom end of the vertical sliding rod (7).
2. The animal head fixture of claim 1, wherein: anchor clamps subassembly (8) include bottom plate (8.1), apron (8.2) and fixed plate (8.3), the top face of bottom plate (8.1) and the bottom face fixed connection of vertical slide bar (7), apron (8.2) set up on bottom plate (8.1) and through first screw (9.1) rather than fixed connection, fixed plate (8.3) set up between bottom plate (8.1) and apron (8.2) and fixed through both centre grippings.
3. The animal head fixture of claim 2, wherein: an observation hole (8.31) is formed in the middle of the fixing plate (8.3), lightening holes (8.32) are formed in two ends of the fixing plate (8.3), and the bottom end of the fixing plate (8.3) is used for being bonded with the head of an animal.
4. A fixture for an animal's head according to claim 3, wherein: u-shaped holes (8.4) which are oppositely arranged are formed in the bottom plate (8.1) and the cover plate (8.2); the bottom plate (8.1) and the cover plate (8.2) are also provided with a plurality of oppositely arranged screw holes (8.5).
5. A device for securing the head of an animal according to claim 1 or 2 or 3 or 4, wherein: the mounting support is characterized in that mounting plates (10) used for mounting the support frame (2) are arranged on two sides of the base (1), and the mounting plates (10) are fixedly connected with side walls on two sides of the base (1).
6. A device for securing the head of an animal according to claim 5, wherein: the support frame (2) comprises a cross rod (2.1) and vertical rods (2.2) arranged at two ends of the cross rod (2.1), the top ends of the vertical rods (2.2) are fixedly connected with the cross rod (2.1), and the bottom ends of the vertical rods (2.2) are fixedly connected with the mounting plate (10).
7. A fixture for an animal's head according to claim 6, wherein: the bottom of montant (2.2) is provided with backing plate (2.3), backing plate (2.3) are through second screw (9.2) and mounting panel (10) fixed connection.
8. The animal head fixture of claim 7, wherein: the middle part of horizontal pole (2.1) is provided with and is used for supplying vertical slide bar (7) to run through mounting hole (2.4) that pass through, vertical slide bar (7) can slide from top to bottom in mounting hole (2.4) and fixed with horizontal pole (2.1) through third screw (9.3).
9. A device for securing the head of an animal according to claim 1 or 2 or 3 or 4, wherein: the animal cage (3) is of a circular barrel-shaped structure, the top end of the animal cage (3) is provided with an opening, and the bottom end of the animal cage is a closed surface.
10. A device for securing the head of an animal according to claim 1 or 2 or 3 or 4, wherein: the opening of the accommodating groove (4) is circular or polygonal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920675574.7U CN210749641U (en) | 2019-05-13 | 2019-05-13 | Animal head fixing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920675574.7U CN210749641U (en) | 2019-05-13 | 2019-05-13 | Animal head fixing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210749641U true CN210749641U (en) | 2020-06-16 |
Family
ID=71057014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920675574.7U Expired - Fee Related CN210749641U (en) | 2019-05-13 | 2019-05-13 | Animal head fixing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210749641U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112545704A (en) * | 2020-12-10 | 2021-03-26 | 中国科学院深圳先进技术研究院 | Big mouse head implantation type fixer |
| CN113456286A (en) * | 2021-06-12 | 2021-10-01 | 梅胜尧 | Fixing device for continuous instillation of drugs for experimental animals |
| CN114209279A (en) * | 2021-04-08 | 2022-03-22 | 浙江大学 | Device for long-time in-vivo imaging of awake small animal |
-
2019
- 2019-05-13 CN CN201920675574.7U patent/CN210749641U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112545704A (en) * | 2020-12-10 | 2021-03-26 | 中国科学院深圳先进技术研究院 | Big mouse head implantation type fixer |
| CN114209279A (en) * | 2021-04-08 | 2022-03-22 | 浙江大学 | Device for long-time in-vivo imaging of awake small animal |
| CN113456286A (en) * | 2021-06-12 | 2021-10-01 | 梅胜尧 | Fixing device for continuous instillation of drugs for experimental animals |
| CN113456286B (en) * | 2021-06-12 | 2024-03-19 | 梅胜尧 | Fixing device for continuous instillation of medicines for experimental animals |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200616 Termination date: 20210513 |