CN207040657U - A kind of in vitro low temperature oxygen carrying machine perfusion device of toy liver - Google Patents
A kind of in vitro low temperature oxygen carrying machine perfusion device of toy liver Download PDFInfo
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- CN207040657U CN207040657U CN201720931914.9U CN201720931914U CN207040657U CN 207040657 U CN207040657 U CN 207040657U CN 201720931914 U CN201720931914 U CN 201720931914U CN 207040657 U CN207040657 U CN 207040657U
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- liver
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Abstract
The utility model provides a kind of in vitro low temperature oxygen carrying machine perfusion device of toy liver, including passes sequentially through organ save set, centrifugal pump, oxygenator, degasification bubbler, flow controller, the pressure sensor of Heparin coated circuits connection；Three-way pipe is respectively arranged between the oxygenator and centrifugal pump, between oxygenator and degasification bubbler.The system provides power by centrifugal pump, and cryogenic oxygen is persistently carried out to toy liver and closes circumfusion, the dosage that this equipment operation is simple, perfusion path is short, cyclic design greatlys save perfusion liquid, is specially adapted to toy liver hypothermia perfusion.
Description
Technical field
It the utility model is related to evaluation and the reparation field of spare-part surgery donor liver, more particularly to a kind of toy liver
In vitro low temperature oxygen carrying machine perfusion device.
Background technology
Since 21 century, organ transplant turn into treatment whole Terminal Disease most effective means, organ transplant always by
It is described as and changed human lives, the important technical of bioscience in 20th century.At present, Chinese organ transplant cause is sent out rapidly
Exhibition, this has not only promoted the development of new and high technology and related science, and has promoted the progress of Medicine Ethics, social values
Transformation.Organ transplant is in Front Fields of Life Sciences all the time, and its perform the operation complexity, degree-of-difficulty factor represent the one of world medicine
Kind high-quality precision and sophisticated technology.However, the serious further development for restricting transplanting cause of the scarcity of organ resource.
To alleviate the short contradiction of donor organ resource, China Health planning commission is with the Red Cross Society of China in 2010
Start Donation of human organs work pilot, after citizen is died within 2013 organ donation include China transplanting work important agenda.
Simultaneously as the shortage of liver, marginality is for liver as the method expanded for liver source, and its status is increasingly by people's weight
Depending on.With the improvement of organ perfusion's liquid, the lifting of store method and surgical technic, the application of Marginal donor liver gradually expands.
However, Clinical Retrospective Study shows heart death donor（donation after cardiac death,DCD）
In the presence of the Warm ischemia injury of longer time, the delayed recovery of renal function occurs for its post-transplantation（delayed graft
Function, DGF）, primary nonfunctional（primary nonfunction, PNF）And microcirculation disorder etc. supplies compared with brain death
Body（donation after brain death, DBD）It is more serious.Marginal donor liver（Fat supplies liver for liver, advanced age for liver, hepatitis
Deng）Caused post-transplantation complication（PNF, IPF, rejection, blood vessel and biliary complications, HBV recurrences etc.）It is still me
The severe challenge that faces.Meanwhile donor organ from get transplanting during by primary disease, hot ischemic, cooling jet flow, cold guarantor
The serial factor such as damage, reperfusion injury is deposited, the quality of donor organ is very different.Therefore, how to assess, safeguard donor organ
Quality, reparation damage are to transplant another significant challenge that career development faces, and current filed of organ transplantation research direction
One of.
It is current research focus to carry out quality evaluation and function reparation for liver for the hot ischemic of Marginal donor liver, particularly DCD.
I devises toy liver low temperature oxygen carrying machine perfusion device, is intervened using low temperature oxygen carrying machine perfusion mode, ground
Study carefully low temperature oxygen carrying machine perfusion the quality for liver is evaluated and repaired.
Utility model content
The purpose of this utility model is to make its symbol after being repaired in low temperature oxygen carrying machine perfusion system to Marginal donor liver
Closing transplanting needs.
The purpose of this utility model can be accomplished by the following way：
A kind of in vitro low temperature oxygen carrying machine perfusion device of toy liver, including pass sequentially through Heparin coated circuits connection
Organ save set, centrifugal pump, oxygenator, degasification bubbler, flow controller, pressure sensor；The oxygenator and centrifugal pump
Between, between oxygenator and degasification bubbler be respectively arranged with three-way pipe, detect actual enter liver partial pressure of oxygen applied to sampling.
As preference：The organ save set is detachable structure, including separable internal's Storage Box
With outer low temperature box；Organ storage's box is provided with portal vein connector and bile duct connector；The Storage Box bottom is provided with
Temperature control circuit board；Organ storage's cassette bottom portion is provided with temperature monitoring simultaneously, and temperature probe is placed in organ storage's box and is applied to
The temperature of monitoring perfusion liquid in real time, temperature is voluntarily set to start prior-warning device, vena portae hepatica trans-portal vein connector and heparin
Coated pipeline connects and composes perfusion inlet.
As preference：The portal vein connector is two-way connector, the pressure sensor and portal vein connector
Connection.
As preference：Also include bile collection device, the bile collection device connects with bile duct connector；The courage
Pipe connections are two-way connector.
As preference：It is mesh-like fiber filtration membrane inside the degasification bubbler, and its top facility has steam vent.
The utility model has the following advantages compared with prior art：1. low temperature oxygen carrying machine perfusion is compared with cold preserve
Unique advantage is that can not only provide nutrient gives nutritional support, promotes the discharge of vivotoxin, and triggers a series of
Inherent immunity caused by protection mechanism and adaptive immune response, so as to reduce the related damage of ischemia-reperfusion, improve transplanting
The quality of thing；2. oxygen is provided to ischemic liver by way of preserving liquid oxygen carrying, to repair ATP consume；Meanwhile can be
Medicine that is anti-oxidant and improving microcirculation etc. is added in perfusion liquid, pharmaceutical intervention treatment is carried out to ischemic liver；4. this system
In improve the device of degasification bubbler, inside is mesh-like fiber filtration membrane, can filter the impurity such as small blood clot, constantly net
Change perfusion liquid；The dosage that 5. this system operation is simple, perfusion path is short, cyclic design greatlys save perfusion liquid, is adapted to
Toy liver hypothermia perfusion.
Brief description of the drawings
Fig. 1 is the utility model structure diagram；
Wherein：1 is organ save set, and 2 be Heparin coated circuits, and 3 be centrifugal pump, and 4 and 6 are three-way pipe, and 5 be that oxygen closes
Device, 7 be degasification bubbler, and 8 be flow controller, and 9 be pressure sensor, and 10 be organ storage's box, and 11 be low temperature box, and 12 be bile
Collection device, portal vein connector 13, bile duct connector 14.
Embodiment
The utility model is described further with reference to embodiment and accompanying drawing.
A kind of in vitro low temperature oxygen carrying machine perfusion device of toy liver, including pass sequentially through Heparin coated circuits 2 and connect
Organ save set 1, centrifugal pump 3, oxygenator 5, degasification bubbler 7, flow controller 8, pressure sensor 9；The oxygenator 5
Between centrifugal pump 3, three-way pipe 4,6 is respectively arranged between oxygenator 5 and degasification bubbler 7, is actually entered applied to sampling detection
Liver partial pressure of oxygen.
The organ save set 1 is detachable structure, including separable internal's Storage Box 10 is low with outside
Warm box 11；Organ storage's box 10 is provided with portal vein connector 13 and bile duct connector 14；The bottom of low temperature box 11 is set
There is temperature control circuit board；The bottom of organ storage's box 10 is provided with temperature monitoring simultaneously, and temperature probe is placed in organ storage's box 10
Applied to the temperature of real-time monitoring perfusion liquid, temperature is voluntarily set to start prior-warning device.
The portal vein connector 13 is two-way connector, and the pressure sensor 9 is connected with portal vein connector, hepatic portal
Vein trans-portal vein connector 13 connects and composes perfusion inlet with Heparin coated circuits.
Also include bile collection device 12, the bile collection device 12 connects with bile duct connector 14；The bile duct connects
Fitting 14 is two-way connector, is connected respectively with liver bile duct and bile collection device 12, and bile enters bile collection device 12.
The inside of degasification bubbler 7 is mesh-like fiber filtration membrane, and its top facility has steam vent, and perfusion liquid, which enters, to be removed
After bubbler, net filtration is shone by inside and falls the impurity such as small blood clot, the gas in perfusion liquid is then discharged by steam vent.
Take appropriate perfusion liquid to add to organ storage's box in oxygen carrying machine perfusion system first, at this moment connect organ and protect
Perfusion pipeline 2 between cryopreservation device 1, centrifugal pump 3, connect with organ save set 1 positioned at one end of organ save set 1 is not direct
Connect, but in organ storage's box below perfusion liquid liquid level, the driving force through centrifugal pump, perfusion liquid successively by oxygenator,
Degasification bubbler, edge perfusion pipeline is back to organ storage's box after excluding bubble, makes entirely to irrigate full perfusion liquid in system pipeline,
Centrifugal pump is stopped, and after donor liver obtains, is placed in the liver perfusate in 4 DEG C of organ storage's boxes, biliary tract passes through courage
Road connector is drawn and is connected to bile collection device, and mixture of ice and water is put into low temperature box and keeps donor liver to be in low temperature shape
State.
Start centrifugal pump first, perfusion liquid is entered pipeline system through oxygenator, degasification bubbler successively by the driving force of centrifugal pump
Unite, after perfusion liquid is full of in whole pipe-line system and discharges air, closes centrifugal pump, now connect vena portae hepatica by portal vein
Device access perfusion pipeline is connect, is again started up centrifugal pump, perfusion liquid starts the cycle over perfusion by portal vein, and perfusion liquid flow direction is as schemed
Shown in middle solid line block arrow, perfusion liquid participates in its evaluation and repair process, the utility model through processes such as peroxide conjunctions into liver
Liver perfusion is carried out using HTK (histidine-tryptophan-ketoglutarate solution), centrifugal pump provides dynamic
HTK is carried out oxygen conjunction by power, oxygenator, is pumped via pipes into liver, and the HTK of vena hepatica outflow is back to through Heparin coated circuits outside liver
Centrifugal pump, complete During Cpb.
Although it is organ save set that this specification, which has more used 1,2 be Heparin coated circuits, and 3 be centrifugal pump, 4
It is three-way pipe with 6,5 be oxygenator, and 7 be degasification bubbler, and 8 be flow controller, and 9 be pressure sensor, and 10 be organ storage
Box, 11 be low temperature box, and 12 be bile collection device, portal vein connector 13, the grade term of bile duct connector 14, but is not precluded from
Use the possibility of other terms.Using these terms just for the sake of more easily describing essence of the present utility model, it
Be construed to any additional limitation and all disagreed with the utility model spirit.
It should be appreciated that the part that this specification does not elaborate belongs to prior art.
It should be appreciated that the above-mentioned description for preferred embodiment is more detailed, therefore can not be considered to this
The limitation of utility model patent protection domain, one of ordinary skill in the art are not departing under enlightenment of the present utility model
Under the ambit that the utility model claims are protected, replacement or deformation can also be made, is each fallen within of the present utility model
Within protection domain, the scope of the present utility model that is claimed should be determined by the appended claims.
Claims (5)
- A kind of 1. in vitro low temperature oxygen carrying machine perfusion device of toy liver, it is characterised in that：Including passing through Heparin coated circuits （2）The organ save set being sequentially communicated（1）, centrifugal pump（3）, oxygenator（5）, degasification bubbler（7）, flow controller（8）, pressure Force snesor（9）；The oxygenator（5）And centrifugal pump（3）Between, oxygenator（5）With degasification bubbler（7）Between be respectively arranged with Three-way pipe（4、6）.
- 2. the in vitro low temperature oxygen carrying machine perfusion device of toy liver as claimed in claim 1, it is characterised in that：The organ Save set（1）For detachable structure, including separable internal's Storage Box（10）With outside constant temperature box（11）；It is described Organ storage's box（10）On be placed with portal vein connector（13）With bile duct connector（14）；The constant temperature box（11）Bottom is provided with Temperature control circuit board；Organ storage's box（10）On be provided with temperature probe.
- 3. the in vitro low temperature oxygen carrying machine perfusion device of toy liver as claimed in claim 2, it is characterised in that：The door is quiet Arteries and veins connector（13）For two-way connector, the pressure sensor（9）With portal vein connector（13）Connection.
- 4. the in vitro low temperature oxygen carrying machine perfusion device of toy liver as claimed in claim 2, it is characterised in that：Also include courage Juice collection device（12）, the bile collection device（12）With bile duct connector（14）Connection；The bile duct connector（14）For Two-way connector.
- 5. the in vitro low temperature oxygen carrying machine perfusion device of toy liver as claimed in claim 1, it is characterised in that：The degasification Bubbler（7）Inside is mesh-like fiber filtration membrane, and its top facility has steam vent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720931914.9U CN207040657U (en) | 2017-07-28 | 2017-07-28 | A kind of in vitro low temperature oxygen carrying machine perfusion device of toy liver |
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| CN201720931914.9U CN207040657U (en) | 2017-07-28 | 2017-07-28 | A kind of in vitro low temperature oxygen carrying machine perfusion device of toy liver |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108432743A (en) * | 2018-06-15 | 2018-08-24 | 广州军区广州总医院 | Portable organ contributes donor machine perfusion system |
| CN109526944A (en) * | 2019-01-07 | 2019-03-29 | 成都泰盟软件有限公司 | A kind of exhaust bubble structure in Perfused isolated heart system |
| CN110669669A (en) * | 2019-11-05 | 2020-01-10 | 西安交通大学医学院第一附属医院 | Modular three-dimensional perfusion cell culture system |
| CN111480644A (en) * | 2019-01-27 | 2020-08-04 | 宋红丽 | Normal-temperature mechanical perfusion combined with gene modification for repairing small animal organ system by stem cells |
| CN112772638A (en) * | 2021-02-24 | 2021-05-11 | 吉林大学第一医院 | Small animal mechanical perfusion liver temperature control device |
-
2017
- 2017-07-28 CN CN201720931914.9U patent/CN207040657U/en active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108432743A (en) * | 2018-06-15 | 2018-08-24 | 广州军区广州总医院 | Portable organ contributes donor machine perfusion system |
| CN108432743B (en) * | 2018-06-15 | 2023-08-11 | 广东丁沃生医疗器械有限公司 | Portable organ donation donor mechanical perfusion system |
| CN109526944A (en) * | 2019-01-07 | 2019-03-29 | 成都泰盟软件有限公司 | A kind of exhaust bubble structure in Perfused isolated heart system |
| CN111480644A (en) * | 2019-01-27 | 2020-08-04 | 宋红丽 | Normal-temperature mechanical perfusion combined with gene modification for repairing small animal organ system by stem cells |
| CN111480644B (en) * | 2019-01-27 | 2024-02-27 | 宋红丽 | Normal temperature mechanical perfusion and gene modification combined stem cell repair small animal organ system |
| CN110669669A (en) * | 2019-11-05 | 2020-01-10 | 西安交通大学医学院第一附属医院 | Modular three-dimensional perfusion cell culture system |
| CN112772638A (en) * | 2021-02-24 | 2021-05-11 | 吉林大学第一医院 | Small animal mechanical perfusion liver temperature control device |
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