CN204811676U - Liver normal atmospheric temperature machinery fills cleaner - Google Patents
Liver normal atmospheric temperature machinery fills cleaner Download PDFInfo
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- CN204811676U CN204811676U CN201520359751.2U CN201520359751U CN204811676U CN 204811676 U CN204811676 U CN 204811676U CN 201520359751 U CN201520359751 U CN 201520359751U CN 204811676 U CN204811676 U CN 204811676U
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Abstract
The utility model provides a liver normal atmospheric temperature machinery fills cleaner, include the accuse temperature container (7) through pipeline circulating connection in proper order, degrease adsorption equipment (6), centrifugal pump (5), oxygenator (4), pressure sensor (3), flow speed controller (2), temperature monitor (1), bubble device (9) are got rid of to the pipeline. The utility model discloses can avoid cold store damage and ischemia reperfusion damage, physiological state can be simulated, the liver function can be appraised through indexs such as choleresis volume, V factors of blood coagulation, bilirubin, normal atmospheric temperature is taken under oxygen fills the state, and liver each item function is close physiological state, can carry out medicine intervention treatment, gene therapy, add degrease adsorption equipment, degrease drug controlled release part is arranged in releasing the degrease medicine and gets into machinery and pour into circulation liver cell metabolism with higher speed, and the adsorbent adsorbs compositions such as triglycerides in the blood, cholesterol, aliphatic acid, constantly purifies blood.
Description
Technical field
The utility model relates to spare-part surgery donor liver operative installations, particularly relates to a kind of liver normal temperature machine perfusion degreasing plant.
Background technology
Due to the shortage for liver, marginality is for liver as the method expanded for liver source, and its status is more and more subject to people and payes attention to.Along with the improvement of organ blood, the lifting of store method and surgical technic, the mark of Marginal donor liver expands gradually.But the post-transplantation complication (PNF, IPF, rejection, blood vessel and biliary complications, HBV recurrence etc.) that Marginal donor liver (fat supplies liver, cold and hot Ischemia Time prolongation etc. for liver, advanced age for liver, hepatitis) brings is still the severe challenge that we face.Fat is maximum at Marginal donor liver proportion for liver, furthers investigate can be the hope that more End-stage liver disease patients bring rehabilitation to it.
For Marginal donor liver, particularly fat carries out quality evaluation and function reparation is current research focus for liver.I devises normal temperature machine perfusion degreasing system state, and application machine perfusion is intervened by degreasing medicine, and the impact of research machine perfusion degreasing effect and the protection to liver function, Comprehensive Evaluation fat supplies the quality of liver and repairs it.Can evaluate the carrying out of steatosis liver donor organ and repair.Greatly extend donor source.
Utility model content
The purpose of this utility model takes after edge in oxygen machine perfusion degreasing system supplies the fat of liver to repair for liver at normal temperature to make it meet transplanting needs.
The purpose of this utility model can realize in the following manner:
A kind of liver normal temperature machine perfusion degreasing plant, comprise by pipeline circulate successively connect temperature controlled container (7), degreasing adsorbent equipment (6), centrifugal pump (5), oxygenator (4), pressure sensor (3), flow speed controller (2), temperature monitor (1), row of conduits air bubble eliminating device (9).
Described degreasing adsorbent equipment (6) is hollow cylindrical, and two ports of cylinder arrange filter screen (10) respectively, is filled with degreasing adsorbent (11) between cylindrical inside, two filter screens.
The two ends of described degreasing adsorbent equipment (6) are respectively arranged with the end cover (8) be connected with pipeline, and described end cover (8) is connected with degreasing adsorbent equipment (6) spiral.
Described degreasing adsorbent (11) comprises degreasing medicine and adsorbent, degreasing medicine controlled releasing part for discharge degreasing medicine enter machine perfusion circulation in accelerate liver cell lipid-metabolism, adsorbent is for adsorbing the lipid composition such as cholesterol, triglycerides, fatty acid in blood.
Degreasing medicine is the mixture of following raw material: 1, adenyl cyclase activator 10uM2, Ppar-alpha ligands 1uM3, PPAR-sigma ligands 1uM4, Pregnane X Receptor activator 10uM, 5, composing type androstane receptor activator 10uM6, Insulin-Like Adipocyte Factor 1uM.
Adsorbent be active carbon, heparin-agarose adsorbent, sulfonation through ethylization cross-linked chitosan, polyacrylic acid grafted Macroporous spherical cellulose adsorbent, styrene season money salt form anion exchange resin, glucan season money cation gel, sulfonation is through propyl group chitosan gel rubber, poly-(the moon one cyclodextrin) resin of ammonification etc.
Described row of conduits air bubble eliminating device (9) is hollow structure, is provided with exhaust outlet above it; Described row of conduits air bubble eliminating device (9) bottom is provided with the feed tube be communicated with temperature monitor (1) and the drain pipe be communicated with temperature controlled container (7), inner at row of conduits air bubble eliminating device (9), the height of the mouth of pipe of drain pipe is higher than the height of the feed tube mouth of pipe.
In the utility model, use homotype blood to carry out liver perfusion, centrifugal pump provides power, and blood is carried out oxygenate by oxygenator, is pumped via pipes into liver, and the blood that vena hepatica flows out is back to centrifugal pump through the outer tunnel of the outer shunt tube of liver, completes outer loop process.
Donor liver is inserted in temperature controlled container after obtaining, and portal vein access perfusion pipeline, biliary tract is put pipe extraction and is connected to bile gathering unit in order to evaluating liver quality.
First in temperature regulating device, blood is added, under the driving of centrifugal pump, blood follows pipeline successively through degreasing adsorbent equipment, oxygenator, pressure sensor, flow speed controller, temperature monitor, row of conduits air bubble eliminating device, discharge the air in whole system, then circumfusion by portal vein, blood is flowed out by the upper and lower inferior caval vein of liver, and the bile of generation enters bile gathering unit, complete whole cyclic process, liver is evaluated and repair process.The parameters such as tight monitoring perfusion ducted flow velocity, pressure, temperature, pressure is excessive, regulates by reducing flow velocity.Degreasing adsorbent equipment promotes liver cell to the metabolism of lipid to reduce steatosis degree by release degreasing medicine on the one hand, on the other hand by the lipid composition such as cholesterol, triglycerides, fatty acid in adsorbent whole system, to reach the effect reducing donor hepatic steatosis degree.
After degreasing adsorbent equipment degreasing absorption is saturated, end cover is taken off from degreasing adsorbent equipment, changes new degreasing adsorbent equipment, can again operate, without the need to integral replacing, cost-saving.
The utility model compared with prior art has the following advantages:
1. cold storage can be avoided to damage and ischemical reperfusion injury;
2. the utility model can simulate physiological status, can evaluating liver function by indexs such as choleresis, blood coagulation V factor, bilirubin;
3. the utility model is under normal temperature takes oxygen perfusion state, and liver various functions, close to physiological status, can carry out pharmaceutical intervention treatment, gene therapy;
4. add degreasing adsorbent equipment, liver cell is promoted to the metabolism of lipid to reduce steatosis degree on the one hand by release degreasing medicine, on the other hand by the lipid composition such as cholesterol, triglycerides, fatty acid in adsorbent whole system, constantly purify the blood.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Fig. 2 is the structural representation of degreasing adsorbent equipment in the utility model;
Wherein: 1 temperature monitor, 2 flow speed controllers, 3 pressure sensors, 4 oxygenators, 5 centrifugal pumps, 6 degreasing adsorbent equipments, 7 temperature controlled containers, 8 end covers, 9 row of conduits air bubble eliminating devices, filter screen 10, degreasing adsorbent 11.
Embodiment
Be described further below in conjunction with embodiment degree the utility model.
A kind of liver normal temperature machine perfusion degreasing plant, comprise by pipeline circulate successively connect temperature controlled container (7), degreasing adsorbent equipment (6), centrifugal pump (5), oxygenator (4), pressure sensor (3), flow speed controller (2), temperature monitor (1), row of conduits air bubble eliminating device (9).
Described degreasing adsorbent equipment (6) is hollow cylindrical, and two ports of cylinder arrange filter screen (10) respectively, is filled with degreasing adsorbent (11) between cylindrical inside, two filter screens.
The two ends of described degreasing adsorbent equipment (6) are respectively arranged with the end cover (8) be connected with pipeline, and described end cover (8) is connected with degreasing adsorbent equipment (6) spiral.
Described degreasing adsorbent (11) comprises degreasing medicine and adsorbent, degreasing medicine controlled releasing part for discharge degreasing medicine enter machine perfusion circulation in accelerate liver cell lipid-metabolism, adsorbent is for adsorbing the lipid composition such as cholesterol, triglycerides, fatty acid in blood.
Degreasing medicine is the mixture of following raw material: 1, adenyl cyclase activator 10uM2, Ppar-alpha ligands 1uM3, PPAR-sigma ligands 1uM4, Pregnane X Receptor activator 10uM, 5, composing type androstane receptor activator 10uM6, Insulin-Like Adipocyte Factor 1uM.
Adsorbent be active carbon, heparin-agarose adsorbent, sulfonation through ethylization cross-linked chitosan, polyacrylic acid grafted Macroporous spherical cellulose adsorbent, styrene season money salt form anion exchange resin, glucan season money cation gel, sulfonation is through propyl group chitosan gel rubber, poly-(the moon one cyclodextrin) resin of ammonification etc.
Described row of conduits air bubble eliminating device (9) is hollow structure, is provided with exhaust outlet above it; Described row of conduits air bubble eliminating device (9) bottom is provided with the feed tube be communicated with temperature monitor (1) and the drain pipe be communicated with temperature controlled container (7), inner at row of conduits air bubble eliminating device (9), the height of the mouth of pipe of drain pipe is higher than the height of the feed tube mouth of pipe.
As Fig. 1, filled arrows is direction of flow of blood, and the utility model relates to temperature control, flow control, Stress control etc.All realize the control to these parameters by temperature, flow velocity, pressure sensor.
Claims (5)
1. a liver normal temperature machine perfusion degreasing plant, it is characterized in that: comprise by pipeline circulate successively connect temperature controlled container (7), degreasing adsorbent equipment (6), centrifugal pump (5), oxygenator (4), pressure sensor (3), flow speed controller (2), temperature monitor (1), row of conduits air bubble eliminating device (9).
2. liver normal temperature machine perfusion degreasing plant as claimed in claim 1, it is characterized in that: described degreasing adsorbent equipment (6) is hollow cylindrical, two ports of cylinder arrange filter screen (10) respectively, are filled with degreasing adsorbent (11) between cylindrical inside, two filter screens.
3. liver normal temperature machine perfusion degreasing plant as claimed in claim 1, it is characterized in that: the two ends of described degreasing adsorbent equipment (6) are respectively arranged with the end cover (8) be connected with pipeline, and described end cover (8) is connected with degreasing adsorbent equipment (6) spiral.
4. liver normal temperature machine perfusion degreasing plant as claimed in claim 2, is characterized in that: described degreasing adsorbent (11) comprises degreasing medicine and adsorbent.
5. liver normal temperature machine perfusion degreasing plant as claimed in claim 1, is characterized in that: described row of conduits air bubble eliminating device (9) is hollow structure, is provided with exhaust outlet above it; Described row of conduits air bubble eliminating device (9) bottom is provided with the feed tube be communicated with temperature monitor (1) and the drain pipe be communicated with temperature controlled container (7), inner at row of conduits air bubble eliminating device (9), the height of the mouth of pipe of drain pipe is higher than the height of the feed tube mouth of pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520359751.2U CN204811676U (en) | 2015-05-29 | 2015-05-29 | Liver normal atmospheric temperature machinery fills cleaner |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520359751.2U CN204811676U (en) | 2015-05-29 | 2015-05-29 | Liver normal atmospheric temperature machinery fills cleaner |
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| Publication Number | Publication Date |
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| CN204811676U true CN204811676U (en) | 2015-12-02 |
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| CN201520359751.2U Active CN204811676U (en) | 2015-05-29 | 2015-05-29 | Liver normal atmospheric temperature machinery fills cleaner |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109692371A (en) * | 2019-01-28 | 2019-04-30 | 四川大学 | It is a kind of from anticoagulant double-layer active carbon blood perfusion device and blood perfusion method |
| CN111937861A (en) * | 2020-08-17 | 2020-11-17 | 南昌大学第二附属医院 | Sevoflurane ischemia reperfusion device and using method |
-
2015
- 2015-05-29 CN CN201520359751.2U patent/CN204811676U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109692371A (en) * | 2019-01-28 | 2019-04-30 | 四川大学 | It is a kind of from anticoagulant double-layer active carbon blood perfusion device and blood perfusion method |
| CN111937861A (en) * | 2020-08-17 | 2020-11-17 | 南昌大学第二附属医院 | Sevoflurane ischemia reperfusion device and using method |
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