WO2018070174A1 - Récipient - Google Patents

Récipient Download PDF

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Publication number
WO2018070174A1
WO2018070174A1 PCT/JP2017/033029 JP2017033029W WO2018070174A1 WO 2018070174 A1 WO2018070174 A1 WO 2018070174A1 JP 2017033029 W JP2017033029 W JP 2017033029W WO 2018070174 A1 WO2018070174 A1 WO 2018070174A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
box
infusion container
substantially rectangular
groove
Prior art date
Application number
PCT/JP2017/033029
Other languages
English (en)
Japanese (ja)
Inventor
康裕 森田
八木　秀樹
雄史 大黒
一郎 脇岡
Original Assignee
ニプロ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニプロ株式会社 filed Critical ニプロ株式会社
Priority to EP17859703.5A priority Critical patent/EP3524223B1/fr
Priority to JP2018544715A priority patent/JP7040454B2/ja
Publication of WO2018070174A1 publication Critical patent/WO2018070174A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1493—Containers with shape retaining means, e.g. to support the structure of the container during emptying or filling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2501/00—Containers having bodies formed in one piece
    • B65D2501/0009—Bottles or similar containers with necks or like restricted apertures designed for pouring contents
    • B65D2501/0018—Ribs
    • B65D2501/0027—Hollow longitudinal ribs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2501/00—Containers having bodies formed in one piece
    • B65D2501/0009—Bottles or similar containers with necks or like restricted apertures designed for pouring contents
    • B65D2501/0081—Bottles of non-circular cross-section

Definitions

  • This invention relates to a container.
  • the liquid in the infusion container When the liquid in the infusion container is discharged, the liquid may remain in the infusion container if the infusion container is deformed to be twisted. Further, deformation due to expansion or the like may occur during sterilization.
  • An object of the present invention is to provide a container that can limit the amount of deformation.
  • the container of the present invention has a membrane part at one end. A hole is formed in the film part. A liquid outlet for discharging liquid is formed at the other end opposite to the one end of the container.
  • the container further includes a box-shaped portion. A direction in which a straight line passing through both the center of the membrane portion and the center of the liquid outlet extends is a first direction, and the box-like portion has a substantially rectangular shape in cross section perpendicular to the first direction.
  • the box-shaped portion is formed with a groove extending in parallel with the first direction at a corner portion of a substantially rectangular shape.
  • the deformation amount of the container can be limited when the liquid is discharged.
  • the box-shaped portion has a flange at a substantially rectangular corner.
  • the collar portion extends in parallel with the first direction and protrudes into the box-shaped portion. Since the rigidity of the container is further increased by the flange portion, the deformation amount of the container can be limited.
  • the box-shaped portion has a wall surface portion extending in the first direction.
  • the groove extends across both ends of the wall surface in the first direction. Since the rigidity of the container is increased by extending the groove over a wide range, the deformation amount can be limited.
  • the groove is formed in all of the corners of the substantially rectangular shape. Since the rigidity of the container is increased by increasing the number of grooves, the deformation amount of the container can be limited.
  • the wall thickness of the box-shaped part is smaller than the depth of the groove. Even in a container having a thin wall thickness, the rigidity of the container is increased by the groove, so that the deformation amount of the container can be limited.
  • a container capable of limiting the amount of deformation can be realized.
  • FIG. 5 is a cross-sectional view of the infusion container along the line VV shown in FIG. 2.
  • FIG. 6 is an enlarged view around a corner portion shown in FIG. 5.
  • FIG. 4 is a cross-sectional view of the infusion container along the line VII-VII shown in FIG. It is sectional drawing of the medical container before a chemical
  • FIG. 2 is a cross-sectional view of the medical container along the line IX-IX shown in FIG.
  • the medical container 1 including the infusion container 100 to which the idea of the present invention can be applied will be described.
  • FIG. 1 is a perspective view showing a schematic configuration of the medical container 1.
  • the medical container 1 includes a connecting member 300 and an infusion container 100.
  • the connecting member 300 is attached to the infusion container 100.
  • the connecting member 300 connects the drug container 500 having a dry drug inside to the infusion container 100.
  • the connecting member 300 is connected to the upper part of the infusion container 100.
  • the direction indicated by the double-headed arrow in FIG. In the vertical direction the direction in which the connecting member 300 is located with respect to the infusion container 100 is the upward direction, and the opposite direction is the downward direction.
  • the infusion container 100 has a solution inside. As the solution, distilled water, physiological saline, glucose solution and the like are generally used, but are not limited thereto.
  • the liquid medicine extraction part 5 is formed in the lower part of the infusion container 100, and the cover member 200 is attached below it.
  • the infusion container 100 a bottle that can be pressed and deformed formed of a relatively soft synthetic resin such as polyethylene, polypropylene, or polyester is usually used.
  • FIG. 2 is a diagram showing a schematic configuration of the infusion container 100 as viewed from the side.
  • FIG. 3 is a perspective view of the infusion container 100 as viewed from above.
  • FIG. 4 is a perspective view of the infusion container 100 as viewed from below.
  • the infusion container 100 includes a mounting portion 2 for mounting the connecting member 300, a box-shaped portion 3 having a substantially rectangular box shape, and a liquid medicine extraction portion 5.
  • the infusion container 100 includes the mounting portion 2 at one end. One end is the upper end.
  • the mounting portion 2 protrudes from the box-shaped portion 3 and has a thread.
  • a connecting member 300 for connecting the drug container 500 is attached to the screw thread.
  • the mounting part 2 has a film part 4 on the upper surface.
  • the infusion container 100 includes the liquid medicine extraction part 5 at the other end opposite to the one end.
  • the other end opposite to the one end is the lower end.
  • a liquid medicine outlet 6 for discharging a liquid medicine which is a liquid medicine in which a dry medicine is dissolved in a dissolving liquid, is formed in the liquid medicine outlet 5.
  • the liquid medicine outlet 6 constitutes a liquid outlet for discharging liquid from the infusion container 100.
  • the film part 4 viewed along the vertical direction has a circular shape.
  • the liquid medicine outlet 6 seen along the vertical direction has a circular shape.
  • a straight line passing through the center of the circular membrane portion 4 and the center of the circular liquid agent outlet 6 is indicated by a one-dot chain line in FIG.
  • a direction in which the center line C extends is indicated by a double-headed arrow in FIG. 2, and this is defined as a first direction DR1.
  • the box-shaped part 3 has a body part 7, a first shoulder part 9, and a second shoulder part 10.
  • FIG. 5 is a cross-sectional view of the infusion container along line VV shown in FIG.
  • the cross section orthogonal to the first direction DR1 of the body portion 7 is substantially rectangular as shown in FIG.
  • a is the length of the short side of the substantially rectangular shape
  • b is the length of the long side of the substantially rectangular shape.
  • the first shoulder portion 9 extends from the trunk portion 7 to the mounting portion 2.
  • the first shoulder portion 9 is a region in which the substantially rectangular cross section of the box-shaped portion 3 orthogonal to the first direction DR1 decreases as it goes upward of the box-shaped portion 3.
  • the second shoulder portion 10 extends from the body portion 7 to the liquid medicine extraction portion 5.
  • the second shoulder portion 10 is a region in which the substantially rectangular cross section of the box-shaped portion 3 that is orthogonal to the first direction DR1 decreases toward the lower side of the box-shaped portion 3.
  • the trunk portion 7 has a wall surface portion 8.
  • the wall surface portion 8 extends in the first direction DR1.
  • the wall surface portion 8 includes a pair of first wall surface portions 8a and a pair of second wall surface portions 8b.
  • the cross section orthogonal to the first direction DR1 of the body portion 7 is substantially rectangular as shown in FIG.
  • the first wall surface portion 8a is a wall surface constituting the long side of the substantially rectangular cross section of the body portion 7 orthogonal to the first direction DR1.
  • the first wall surface portions 8a are symmetric with respect to the center line C of FIG.
  • the second wall surface portion 8b is a wall surface constituting the short side of the substantially rectangular cross section of the body portion 7 orthogonal to the first direction DR1.
  • the second wall surface portions 8b are symmetrical with each other about the center line C of FIG.
  • the body portion 7 has a corner portion 11. As shown in FIG. 5, the corner portions 11 are the four corners of a substantially rectangular cross section of the body portion 7 orthogonal to the first direction DR1.
  • the corner portion 11 connects the first wall surface portion 8a and the second wall surface portion 8b.
  • the corner 11 is recessed toward the inside of the infusion container 100.
  • the corner portion 11 is curved toward the center line.
  • the corner 11 is curved toward the inside of the infusion container 100.
  • the wall surface portion 8 is curved toward the outside of the infusion container 100.
  • Grooves 12 are formed when the corners 11 are recessed toward the inside of the infusion container 100.
  • the groove 12 extends in the first direction DR1 as shown in FIG.
  • the groove 12 extends from an end connecting the body 7 and the first shoulder 9 to an end connecting the body 7 and the second shoulder 10.
  • the groove 12 may also be formed in the wall surface portion 8.
  • FIG. 6 is an enlarged view around the corner 11 shown in FIG.
  • the thickness of the corner 11 be the wall thickness t.
  • the broken line in FIG. 6 is a line that connects an end portion connected to the first wall surface portion 8a of the corner portion 11 and an end portion connected to the second wall surface portion 8b.
  • the distance from the broken line to the deepest part of the corner 11 is defined as the groove depth d.
  • the groove depth d is determined along a line orthogonal to the broken line.
  • the dimension of the infusion container 100 is determined so that the wall thickness t is t ⁇ d with respect to the groove depth d.
  • the dimension of the infusion container 100 is defined so that it may become smaller than the groove depth d.
  • FIG. 7 is a cross-sectional view of the infusion container 100 along the line VII-VII shown in FIG.
  • the box-shaped portion 3 has a flange portion 13 that extends in parallel with the first direction DR1 and protrudes into the box-shaped portion 3 at a substantially rectangular corner portion 11.
  • the corner portion 11 is recessed toward the inside of the infusion container 100, so that the collar portion 13 is formed.
  • the collar portion 13 may be formed in a portion other than the corner portion 11.
  • the membrane portion 4 is formed with a communication hole 14 that allows the drug container 500 and the infusion container 100 to communicate with each other in a state where the drug container 500 and the infusion container 100 are connected via the connecting member 300.
  • FIG. 8 is a cross-sectional view of the medical container 1 before the drug container 500 and the infusion container 100 communicate with each other.
  • FIG. 8 shows a state before the communication hole 14 is formed in the membrane portion 4 in the same cross section as the cross section of the medical container 1 shown in FIG. 9 described later.
  • FIG. 8 shows a state in which the medicine container 500 is fixed to the connecting member 300. In the state of FIG. 8, the communication hole 14 is not formed in the film part 4.
  • FIG. 9 is a cross-sectional view of the medical container along the line IX-IX shown in FIG.
  • FIG. 9 is a cross-sectional view after the drug container 500 and the infusion container 100 communicate with each other.
  • the drug container 500 is pushed into the infusion container 100 via the connecting member 300, the first puncture needle 356 b penetrates the membrane part 4, and the communication hole 14 that communicates the drug container 500 and the infusion container 100 is formed in the infusion container 100. It is formed.
  • the internal space of the medicine container 500 and the internal space of the infusion container 100 are in communication with each other.
  • the dry medicine inside the medicine container 500 is mixed with the solution inside the infusion container 100 and discharged from the liquid medicine outlet 6 as a liquid medicine.
  • the medical container 1 includes an infusion container 100 and a connecting member 300 as shown in FIG.
  • the infusion container 100 has the membrane part 4 at the upper end.
  • a liquid medicine outlet 6 is formed at the lower end of the infusion container 100.
  • the infusion container 100 further has a box-shaped part 3.
  • the direction in which a straight line passing through both the center of the membrane part 4 and the center of the liquid medicine outlet 6 extends is defined as a first direction DR1
  • the box-shaped part 3 has a substantially rectangular cross section perpendicular to the first direction DR1
  • a groove 12 extending in parallel with the first direction DR1 is formed in a corner part 11 of a substantially rectangular cross section.
  • the rigidity of the infusion container 100 is increased, the deformation amount of the infusion container 100 can be limited when the liquid is discharged. This makes it difficult for the liquid to remain in the infusion container 100, so that the liquid in the infusion container 100 can be used to the end, and the economy is increased. Further, since the rigidity of the infusion container 100 is increased, deformation of the infusion container 100 due to thermal stress can be suppressed when the infusion container 100 is sterilized with high-temperature and high-pressure steam.
  • the box-shaped portion 3 has a flange portion 13 at a corner portion 11 of a substantially rectangular cross section orthogonal to the first direction DR1.
  • the collar portion 13 extends in parallel with the first direction DR1 and protrudes into the box-shaped portion 3. Since the rigidity of the infusion container 100 is further increased by the collar portion 13, the deformation amount of the infusion container 100 can be limited.
  • the box-shaped part 3 has a wall surface part 8 extending in the first direction DR1.
  • the wall surface portion 8 includes a pair of first wall surface portions 8a and a pair of second wall surface portions 8b.
  • the groove 12 extends across both ends of the wall surface portion 8 in the first direction. Since the rigidity of the infusion container is further increased by extending the groove 12 over a wide range, the amount of deformation can be limited.
  • the grooves 12 are formed in all of the substantially rectangular corners 11. Since the rigidity of the infusion container 100 is increased by increasing the number of the grooves 12, the amount of deformation of the infusion container can be limited.
  • the wall thickness t of the corner 11 is smaller than the groove depth d. Even in the infusion container 100 having a thin wall thickness, the rigidity of the infusion container 100 is increased by the grooves 12, and therefore, the deformation amount of the infusion container 100 can be limited.
  • the infusion container 100 of the present embodiment is used for a medical container 1 as shown in FIG.
  • the medical container 1 includes an infusion container 100 and a connecting member 300.
  • the infusion container 100 has the membrane part 4 at the upper end.
  • a liquid medicine outlet 6 is formed at the lower end of the infusion container 100.
  • the infusion container 100 further has a box-shaped part 3.
  • the direction in which a straight line passing through both the center of the membrane part 4 and the center of the liquid medicine outlet 6 extends is defined as a first direction DR1, and the box-shaped part 3 has a substantially rectangular cross section perpendicular to the first direction DR1.
  • Have Grooves 12 extending in parallel with the first direction DR1 are formed in corner portions 11 of the substantially rectangular cross section of the box-shaped portion 3.
  • the membrane part 4 and the liquid medicine outlet 6 do not have to be circular.
  • the center of gravity of each shape is defined as the center.
  • the intersection of the diagonal lines of the rectangle is the center.
  • the dimensions of the infusion container before and after high-pressure steam sterilization were measured for each of the infusion container in which the groove was not formed and the infusion container 100 in which the groove 12 was formed. .
  • the measurement results are shown below.
  • the short side is a shown in FIG. 5, and the long side is b shown in FIG.
  • the short side a and the long side b were measured using LS-9120M manufactured by Keyence Corporation.
  • the infusion container 100 was placed on the measuring instrument with the cover member 200 facing down, and the short side a and the long side b of the infusion container 100 at a position of 70 mm in height were measured one by one.
  • the groove depth d was measured using Olympus STM7.
  • the square groove depth d of the substantially rectangular box-shaped infusion container 100 was measured one by one. Table 1 shows the maximum values of the dimension measurement results for each of the short side a, the long side b, and the groove depth d in 10 infusion containers.
  • the groove depth d of the infusion container before the high-pressure steam sterilization treatment was 2.20 [mm] for both the infusion container in which no groove was formed and the infusion container 100 in which the groove 12 was formed.
  • the length of the short side a increased by 9.92 [mm] and the length of the long side b increased by 2.91 [mm] after sterilization.
  • the length of the short side a increased by 4.92 [mm] and the length of the long side b increased by 2.19 [mm] after sterilization.
  • the infusion container without grooves was expanded, and the corners became arcuate.
  • the infusion container 100 in which the groove 12 was formed did not expand, and the corner 11 did not have an arc shape. Thereby, it was shown that the infusion container 100 in which the groove 12 is formed has less dimensional change, and the deformation of the container can be suppressed than the infusion container in which the groove is not formed.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Ce récipient est pourvu d'une section de membrane (4) à une extrémité de celui-ci. Un orifice d'extraction de liquide pour évacuer le liquide est formé à l'extrémité opposée à la première extrémité du récipient. Le récipient est en outre pourvu d'une section en forme de boîte (3). Lorsqu'une direction, dans laquelle s'étend une ligne droite passant à la fois au centre de la section de membrane (4) et au centre de l'orifice d'extraction de liquide, est définie comme une première direction (DR1), la section en forme de boîte (3) a une section transversale ayant une forme sensiblement rectangulaire lorsqu'elle est coupée dans une direction orthogonale à la première direction (DR1). La section en forme de boîte (3) a une rainure (12) formée au niveau de chaque coin (11) de la forme sensiblement rectangulaire de manière à s'étendre parallèlement à la première direction (DR1).
PCT/JP2017/033029 2016-10-14 2017-09-13 Récipient WO2018070174A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP17859703.5A EP3524223B1 (fr) 2016-10-14 2017-09-13 Récipient
JP2018544715A JP7040454B2 (ja) 2016-10-14 2017-09-13 容器

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016202394 2016-10-14
JP2016-202394 2016-10-14

Publications (1)

Publication Number Publication Date
WO2018070174A1 true WO2018070174A1 (fr) 2018-04-19

Family

ID=61906252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2017/033029 WO2018070174A1 (fr) 2016-10-14 2017-09-13 Récipient

Country Status (3)

Country Link
EP (1) EP3524223B1 (fr)
JP (1) JP7040454B2 (fr)
WO (1) WO2018070174A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12005408B1 (en) 2023-04-14 2024-06-11 Sharkninja Operating Llc Mixing funnel
US12017192B1 (en) 2023-06-16 2024-06-25 Sharkninja Operating Llc Carbonation mixing nozzles

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05337163A (ja) * 1992-06-05 1993-12-21 Nissho Corp 連通手段を備えた輸液容器
WO2013069194A1 (fr) * 2011-11-09 2013-05-16 東洋製罐株式会社 Récipient en résine angulaire et filière de soufflage
WO2013175970A1 (fr) 2012-05-23 2013-11-28 ニプロ株式会社 Récipient médical
JP2015163528A (ja) * 2014-02-03 2015-09-10 大日本印刷株式会社 プラスチックボトル

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3225497B2 (ja) * 1991-10-16 2001-11-05 ニプロ株式会社 薬液注入装置
JP2604807Y2 (ja) * 1993-04-26 2000-06-05 株式会社吉野工業所 ボトル
JP3050587U (ja) 1998-01-16 1998-07-21 日精エー・エス・ビー機械株式会社 二軸延伸ブロー成形容器
JP4849313B2 (ja) 2005-12-26 2012-01-11 株式会社吉野工業所 ラベル付き樹脂製容器
MX2013000558A (es) * 2010-07-20 2013-06-05 Amcor Ltd Costillas de refuerzo de esqueleto / inserto de accion lateral.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05337163A (ja) * 1992-06-05 1993-12-21 Nissho Corp 連通手段を備えた輸液容器
WO2013069194A1 (fr) * 2011-11-09 2013-05-16 東洋製罐株式会社 Récipient en résine angulaire et filière de soufflage
WO2013175970A1 (fr) 2012-05-23 2013-11-28 ニプロ株式会社 Récipient médical
JP2015163528A (ja) * 2014-02-03 2015-09-10 大日本印刷株式会社 プラスチックボトル

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3524223A4

Also Published As

Publication number Publication date
JP7040454B2 (ja) 2022-03-23
EP3524223A4 (fr) 2020-05-20
EP3524223A1 (fr) 2019-08-14
JPWO2018070174A1 (ja) 2019-08-08
EP3524223B1 (fr) 2022-08-10

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