WO2017219835A1 - Solution de rinçage kangjun xiaoyan - Google Patents

Solution de rinçage kangjun xiaoyan Download PDF

Info

Publication number
WO2017219835A1
WO2017219835A1 PCT/CN2017/086763 CN2017086763W WO2017219835A1 WO 2017219835 A1 WO2017219835 A1 WO 2017219835A1 CN 2017086763 W CN2017086763 W CN 2017086763W WO 2017219835 A1 WO2017219835 A1 WO 2017219835A1
Authority
WO
WIPO (PCT)
Prior art keywords
combination
weight
antibacterial anti
amount
inflammatory
Prior art date
Application number
PCT/CN2017/086763
Other languages
English (en)
Chinese (zh)
Inventor
吴克
Original Assignee
江苏奇力康皮肤药业有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江苏奇力康皮肤药业有限公司 filed Critical 江苏奇力康皮肤药业有限公司
Publication of WO2017219835A1 publication Critical patent/WO2017219835A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds

Definitions

  • the invention relates to a mouthwash, in particular to an antibacterial anti-inflammatory mouthwash.
  • Gingivitis is a common disease of the periodontal tissue. It is caused by inadvertent oral hygiene, long-term stimulation caused by soft tartar and hard tartar formed by food residue, bacteria and other teeth around the teeth, and incorrect oral cavity. Health habits, vitamin deficiency and other reasons.
  • Some mouthwashes have poor antibacterial effect and short antibacterial time, which can not really achieve antibacterial and anti-inflammatory effects.
  • an object of the present invention is to provide an antibacterial anti-inflammatory mouthwash which can effectively prevent bleeding of gums and inhibit oral bacteria.
  • An antibacterial anti-inflammatory mouthwash containing deionized water as a main component and at least a combination of tranexamic acid, chlorogenic acid, andrographis extract and honeysuckle extract.
  • the antibacterial anti-inflammatory mouthwash has a content of the tranexamic acid of 0.1 to 0.3% by weight.
  • the antibacterial anti-inflammatory mouthwash wherein the content of the chlorogenic acid is 0.1 to 0.3% by weight.
  • the antibacterial anti-inflammatory mouthwash wherein the extract of Andrographis paniculata is 0.1 to 0.3% by weight.
  • the antibacterial anti-inflammatory mouthwash wherein the honeysuckle extract is contained in an amount of 0.1 to 0.3% by weight.
  • the antibacterial anti-inflammatory mouthwash further comprises a moisturizer, a surfactant, a sweetener, a flavor, a cooling agent and a preservative.
  • the antibacterial anti-inflammatory mouthwash wherein the humectant is selected from the group consisting of sorbitol, propylene glycol or a combination thereof; the humectant is contained in an amount of 10 to 45 wt%;
  • the surfactant is selected from sodium lauryl sulfate, poloxamer, polysorbate or a combination thereof; the surfactant is present in an amount of 2 to 5 wt%;
  • the sweetener is selected from the group consisting of saccharin, sodium saccharin, aspartame, stevioside, sucralose, xylitol or a combination thereof; the sweetener is present in an amount of 0.1 to 0.5% by weight;
  • the flavor is selected from the group consisting of mint flavor, spearmint flavor, green tea flavor, milk flavor, fruit flavor, or a combination thereof; the flavor is in an amount of 0.1 to 0.5% by weight;
  • the cooling agent is selected from the group consisting of borneol, menthol or a combination thereof; the content of the cooling agent is 0.1 to 0.3% by weight;
  • the preservative is selected from the group consisting of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methylparaben, propylparaben, butylparaben or a combination thereof; the content of the preservative is 0.05 to 0.2 Wt%.
  • the beneficial effects of the invention are as follows: in the present case, the combination of chlorogenic acid, andrographis extract and honeysuckle extract combined with tranexamic acid can prevent inflammation and quickly prevent gum bleeding. Effectively inhibit the efficacy of oral bacteria, and achieve the purpose of treating both the symptoms and the root causes.
  • an antibacterial anti-inflammatory mouthwash having a deionized water as a main component and at least a combination of tranexamic acid, chlorogenic acid, andrographolide extract and honeysuckle extract is added.
  • the traditional Chinese medicine extract herein refers to a solid obtained by extracting a Chinese medicine by a solvent and then removing the solvent.
  • Tranexamic acid, chlorogenic acid, andrographis extract and honeysuckle extract are an inseparable organic whole.
  • the four components can promote each other to produce synergistic effects, and jointly improve the antibacterial and anti-inflammatory ability of mouthwash. Moreover, the content of these four components should be limited, as follows:
  • the content of tranexamic acid is preferably from 0.1 to 0.3% by weight.
  • the content of chlorogenic acid is preferably from 0.1 to 0.3% by weight.
  • the content of the Andrographis paniculata extract is preferably from 0.1 to 0.3% by weight.
  • the content of the honeysuckle extract is preferably from 0.1 to 0.3% by weight.
  • a moisturizer As another embodiment of the present invention, a moisturizer, a surfactant, a sweetener, a fragrance, a cooling agent and a preservative are also included.
  • the humectant is selected from the group consisting of sorbitol, propylene glycol or a combination thereof; the content of the humectant is 10 to 45 wt%;
  • the surfactant is selected from sodium lauryl sulfate, poloxamer, polysorbate or a combination thereof; the surfactant is contained in an amount of 2 to 5 wt%;
  • the sweetener is selected from the group consisting of saccharin, sodium saccharin, aspartame, stevioside, sucralose, xylitol or a combination thereof; the sweetener is contained in an amount of 0.1 to 0.5% by weight;
  • the fragrance is selected from the group consisting of mint flavor, spearmint spice, green tea flavor, milk flavor, fruit flavor, or a combination thereof; the content of the flavor is 0.1 to 0.5 wt%;
  • the cooling agent is selected from the group consisting of borneol, menthol or a combination thereof; the content of the cooling agent is 0.1 to 0.3% by weight;
  • the preservative is selected from the group consisting of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methylparaben, propylparaben, butylparaben or a combination thereof; the content of the preservative is 0.05 to 0.2% by weight.
  • Table 1 lists the specific components and their contents of the different examples, wherein the balance outside each component is deionized water, and the sum of each component and deionized water is 100%. Deionized water is omitted in Table 1.
  • Example 1 Example 2
  • Example 3 Example 4 Tranexamic acid 0.1wt% 0.3wt% 0.2wt% 0.1wt% Chlorogenic acid 0.1wt% 0.3wt% 0.2wt% 0.3wt% Andrographis extract 0.1wt% 0.3wt% 0.2wt% 0.1wt% Honeysuckle extract 0.1wt% 0.3wt% 0.2wt% 0.3wt% moisturizer 10wt% 45wt% 10wt% 45wt% Surfactant 2wt% 5wt% 2wt% 5wt% Sweetener 0.1wt% 0.5wt% 0.1wt% 0.5wt% spices 0.1wt% 0.5wt% 0.1wt% 0.5wt% Cooling agent 0.1wt% 0.3wt% 0.1wt% 0.3wt% preservative 0.05wt% 0.2wt% 0.05wt% 0.2wt% 0.2wt% 0.2wt% 0.2wt% 0.2
  • Table 2 lists the results of the antibacterial experiments of Examples 1-4.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

Cette solution de rinçage Kangjun Xiaoyan comprend essentiellement de l'eau désionisée à laquelle on ajoute pas moins d'un acide tranexamique, d'un acide chlorogénique, d'un extrait d'Andrographis paniculata et d'un extrait de Lonicera japonica. La mise en oeuvre d'un procédé d'utilisation combinant un acide chlorogénique, un extrait d'Andrographis paniculata et un extrait de Lonicera japonica avec un acide tranexamique permet de réduire les inflammations, d'éviter les saignements de gencive, d'inhiber efficacement les effets négatifs des bactéries dans la cavité bucale, et ce, afin d'assurer un traitement en profondeur qui s'attaque à la cause et non pas seulement aux symptômes.
PCT/CN2017/086763 2016-06-21 2017-06-01 Solution de rinçage kangjun xiaoyan WO2017219835A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610444454.7A CN105963190A (zh) 2016-06-21 2016-06-21 抗菌消炎漱口水
CN201610444454.7 2016-06-21

Publications (1)

Publication Number Publication Date
WO2017219835A1 true WO2017219835A1 (fr) 2017-12-28

Family

ID=57021903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2017/086763 WO2017219835A1 (fr) 2016-06-21 2017-06-01 Solution de rinçage kangjun xiaoyan

Country Status (2)

Country Link
CN (1) CN105963190A (fr)
WO (1) WO2017219835A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112057375A (zh) * 2019-09-11 2020-12-11 东莞市洁立舒商贸有限公司 一种天然口腔保健漱口水及其制备方法
CN112957288A (zh) * 2021-01-29 2021-06-15 深圳市西马龙科技有限公司 一种具有高效清新口气的漱口水及其制备方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105963190A (zh) * 2016-06-21 2016-09-28 江苏奇力康皮肤药业有限公司 抗菌消炎漱口水
CN107296774A (zh) * 2017-08-21 2017-10-27 王金强 一种抗菌漱口水
CN107789284A (zh) * 2017-11-26 2018-03-13 广西鑫华农业科技股份有限公司 一种黄姜漱口水及其制备方法
CN108125813A (zh) * 2018-01-17 2018-06-08 卢鹤文 一种杀菌消炎消肿漱齿液
US11666532B2 (en) 2018-01-19 2023-06-06 Hyloris Developments Sa Tranexamic acid oral solution
CN108186541A (zh) * 2018-03-19 2018-06-22 纳诺神蜂（福建）个人护理用品有限公司 多重功效型漱口水及其制备方法
CN108542874A (zh) * 2018-07-17 2018-09-18 合肥雪立歆农业科技有限公司 一种抗菌消炎漱口水

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040037790A1 (en) * 2002-08-23 2004-02-26 Shuji Watanabe Oral composition, method of making the oral composition and oral hygiene method in japanese and chinese herbal remedy
JP2005170867A (ja) * 2003-12-12 2005-06-30 Lion Corp 口腔用組成物
CN1947697A (zh) * 2006-09-27 2007-04-18 天津市希勒玛生物科技有限公司 一种草本真水及其制备方法
CN101095656A (zh) * 2007-07-19 2008-01-02 法国医药集团 穿心莲在制备牙齿清洁用品中的应用及其牙齿清洁用品
CN102000005A (zh) * 2010-11-27 2011-04-06 天津市顶硕科贸有限公司 口腔护理液
CN105168012A (zh) * 2015-08-04 2015-12-23 苏州泽达兴邦医药科技有限公司 一种复方药物牙膏及制作方法
CN105497052A (zh) * 2015-12-10 2016-04-20 苏州泽达兴邦医药科技有限公司 复方药物漱口水
CN105963190A (zh) * 2016-06-21 2016-09-28 江苏奇力康皮肤药业有限公司 抗菌消炎漱口水

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101627965B (zh) * 2009-07-21 2011-03-30 清华大学 一种漱口水及其制备方法
CN104800261B (zh) * 2015-05-15 2018-04-10 大连大学 一种丁香复方漱口水

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040037790A1 (en) * 2002-08-23 2004-02-26 Shuji Watanabe Oral composition, method of making the oral composition and oral hygiene method in japanese and chinese herbal remedy
JP2005170867A (ja) * 2003-12-12 2005-06-30 Lion Corp 口腔用組成物
CN1947697A (zh) * 2006-09-27 2007-04-18 天津市希勒玛生物科技有限公司 一种草本真水及其制备方法
CN101095656A (zh) * 2007-07-19 2008-01-02 法国医药集团 穿心莲在制备牙齿清洁用品中的应用及其牙齿清洁用品
CN102000005A (zh) * 2010-11-27 2011-04-06 天津市顶硕科贸有限公司 口腔护理液
CN105168012A (zh) * 2015-08-04 2015-12-23 苏州泽达兴邦医药科技有限公司 一种复方药物牙膏及制作方法
CN105497052A (zh) * 2015-12-10 2016-04-20 苏州泽达兴邦医药科技有限公司 复方药物漱口水
CN105963190A (zh) * 2016-06-21 2016-09-28 江苏奇力康皮肤药业有限公司 抗菌消炎漱口水

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112057375A (zh) * 2019-09-11 2020-12-11 东莞市洁立舒商贸有限公司 一种天然口腔保健漱口水及其制备方法
CN112957288A (zh) * 2021-01-29 2021-06-15 深圳市西马龙科技有限公司 一种具有高效清新口气的漱口水及其制备方法

Also Published As

Publication number Publication date
CN105963190A (zh) 2016-09-28

Similar Documents

Publication Publication Date Title
WO2017219835A1 (fr) Solution de rinçage kangjun xiaoyan
CN106265423B (zh) 具有清火消痛作用的口腔护理组合物
CN105997659A (zh) 消炎抑菌漱口水
CN107106477B (zh) 口腔护理组合物和使用方法
KR20000016351A (ko) 구강 위생물용 항균제
CN105497052A (zh) 复方药物漱口水
CN108464956A (zh) 一种应用于口腔的组合物及其制备方法与应用
CN108403544B (zh) 一种儿童口腔护理组合物及其制备方法
WO2017219579A1 (fr) Solution de rinçage à action antibactérienne de longue durée
JP2019535767A5 (fr)
CN103933275A (zh) 一种抗菌消毒药剂及其制作方法
KR20160088841A (ko) 에모딘 또는 이의 약학적으로 허용 가능한 염을 함유하는 구강질환 예방 또는 치료용 조성물
KR20170141053A (ko) 치자나무 추출물을 포함하는 구강질환 예방 또는 치료용 조성물
WO2017206015A1 (fr) Gargarisme antibactérien de longue durée et de protection des dents
KR20170141034A (ko) 인삼 추출물을 포함하는 구강질환 예방 또는 치료용 조성물
CN110251664A (zh) 一种含有溶菌酶和植物提取物的口腔护理液
KR101596438B1 (ko) 글라브리딘 또는 이의 약학적으로 허용 가능한 염을 함유하는 구강질환 예방 또는 치료용 조성물
KR20170141030A (ko) 시스타노사이드 에이를 포함하는 구강질환 예방 또는 치료용 조성물
KR102415612B1 (ko) 과체 추출물을 포함하는 구강질환 예방 또는 치료용 조성물
KR101630829B1 (ko) 에키나코사이드 또는 이의 약학적으로 허용 가능한 염을 함유하는 구강질환 예방 또는 치료용 조성물
KR101548254B1 (ko) 유황, 명반 및 식초를 유효성분으로 포함하는 피부 질환 치료용 조성물
JP3184884U (ja) 洗口錠剤の層状構造
KR20170120411A (ko) 스코폴레틴을 포함하는 구강질환 예방 또는 치료용 조성물
KR20090130892A (ko) 허브추출물 함유 치약
KR20170141057A (ko) 팥꽃 추출물을 포함하는 구강질환 예방 또는 치료용 조성물

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17814573

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17814573

Country of ref document: EP

Kind code of ref document: A1