WO2017219835A1

WO2017219835A1 - Anti-bacterial and anti-inflammatory mouthwash

Info

Publication number: WO2017219835A1
Application number: PCT/CN2017/086763
Authority: WO
Inventors: 吴克
Original assignee: 江苏奇力康皮肤药业有限公司
Priority date: 2016-06-21
Filing date: 2017-06-01
Publication date: 2017-12-28
Also published as: CN105963190A

Abstract

Disclosed is an anti-bacterial and anti-inflammatory mouthwash, mainly composed of deionized water, and at least added to with a combination of a tranexamic acid, chlorogenic acid, Andrographis paniculata extract and honeysuckle extract. By using means of combining the chlorogenic acid, Andrographis paniculata extract and honeysuckle extract with tranexamic acid, the mouthwash has the functions of anti-inflammation, rapid prevention of gum bleeding and effective inhibition of oral bacteria, so as toachieve the purpose of treating the symptoms and the causes.

Description

Antibacterial anti-inflammatory mouthwash

Technical field

The invention relates to a mouthwash, in particular to an antibacterial anti-inflammatory mouthwash.

Background technique

Gingivitis is a common disease of the periodontal tissue. It is caused by inadvertent oral hygiene, long-term stimulation caused by soft tartar and hard tartar formed by food residue, bacteria and other teeth around the teeth, and incorrect oral cavity. Health habits, vitamin deficiency and other reasons.

At present, there are some mouthwashes with uneven quality on the market. Some mouthwashes have poor antibacterial effect and short antibacterial time, which can not really achieve antibacterial and anti-inflammatory effects.

Summary of the invention

In view of the deficiencies of the prior art, an object of the present invention is to provide an antibacterial anti-inflammatory mouthwash which can effectively prevent bleeding of gums and inhibit oral bacteria.

The technical solution of the present invention is summarized as follows:

An antibacterial anti-inflammatory mouthwash containing deionized water as a main component and at least a combination of tranexamic acid, chlorogenic acid, andrographis extract and honeysuckle extract.

Preferably, the antibacterial anti-inflammatory mouthwash has a content of the tranexamic acid of 0.1 to 0.3% by weight.

Preferably, the antibacterial anti-inflammatory mouthwash, wherein the content of the chlorogenic acid is 0.1 to 0.3% by weight.

Preferably, the antibacterial anti-inflammatory mouthwash, wherein the extract of Andrographis paniculata is 0.1 to 0.3% by weight.

Preferably, the antibacterial anti-inflammatory mouthwash, wherein the honeysuckle extract is contained in an amount of 0.1 to 0.3% by weight.

Preferably, the antibacterial anti-inflammatory mouthwash further comprises a moisturizer, a surfactant, a sweetener, a flavor, a cooling agent and a preservative.

Preferably, the antibacterial anti-inflammatory mouthwash, wherein the humectant is selected from the group consisting of sorbitol, propylene glycol or a combination thereof; the humectant is contained in an amount of 10 to 45 wt%;

The surfactant is selected from sodium lauryl sulfate, poloxamer, polysorbate or a combination thereof; the surfactant is present in an amount of 2 to 5 wt%;

The sweetener is selected from the group consisting of saccharin, sodium saccharin, aspartame, stevioside, sucralose, xylitol or a combination thereof; the sweetener is present in an amount of 0.1 to 0.5% by weight;

The flavor is selected from the group consisting of mint flavor, spearmint flavor, green tea flavor, milk flavor, fruit flavor, or a combination thereof; the flavor is in an amount of 0.1 to 0.5% by weight;

The cooling agent is selected from the group consisting of borneol, menthol or a combination thereof; the content of the cooling agent is 0.1 to 0.3% by weight;

The preservative is selected from the group consisting of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methylparaben, propylparaben, butylparaben or a combination thereof; the content of the preservative is 0.05 to 0.2 Wt%.

The beneficial effects of the invention are as follows: in the present case, the combination of chlorogenic acid, andrographis extract and honeysuckle extract combined with tranexamic acid can prevent inflammation and quickly prevent gum bleeding. Effectively inhibit the efficacy of oral bacteria, and achieve the purpose of treating both the symptoms and the root causes.

detailed description

The present invention will be further described in detail below with reference to the embodiments, so that those skilled in the art can refer to the description.

In the present invention, an antibacterial anti-inflammatory mouthwash having a deionized water as a main component and at least a combination of tranexamic acid, chlorogenic acid, andrographolide extract and honeysuckle extract is added. The traditional Chinese medicine extract herein refers to a solid obtained by extracting a Chinese medicine by a solvent and then removing the solvent. Tranexamic acid, chlorogenic acid, andrographis extract and honeysuckle extract are an inseparable organic whole. The four components can promote each other to produce synergistic effects, and jointly improve the antibacterial and anti-inflammatory ability of mouthwash. Moreover, the content of these four components should be limited, as follows:

In the above embodiment, the content of tranexamic acid is preferably from 0.1 to 0.3% by weight.

In the above embodiment, the content of chlorogenic acid is preferably from 0.1 to 0.3% by weight.

In the above embodiment, the content of the Andrographis paniculata extract is preferably from 0.1 to 0.3% by weight.

In the above embodiment, the content of the honeysuckle extract is preferably from 0.1 to 0.3% by weight.

As another embodiment of the present invention, a moisturizer, a surfactant, a sweetener, a fragrance, a cooling agent and a preservative are also included.

In this embodiment, the humectant is selected from the group consisting of sorbitol, propylene glycol or a combination thereof; the content of the humectant is 10 to 45 wt%;

The surfactant is selected from sodium lauryl sulfate, poloxamer, polysorbate or a combination thereof; the surfactant is contained in an amount of 2 to 5 wt%;

The sweetener is selected from the group consisting of saccharin, sodium saccharin, aspartame, stevioside, sucralose, xylitol or a combination thereof; the sweetener is contained in an amount of 0.1 to 0.5% by weight;

The fragrance is selected from the group consisting of mint flavor, spearmint spice, green tea flavor, milk flavor, fruit flavor, or a combination thereof; the content of the flavor is 0.1 to 0.5 wt%;

The preservative is selected from the group consisting of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methylparaben, propylparaben, butylparaben or a combination thereof; the content of the preservative is 0.05 to 0.2% by weight.

Table 1 lists the specific components and their contents of the different examples, wherein the balance outside each component is deionized water, and the sum of each component and deionized water is 100%. Deionized water is omitted in Table 1.

Table I

	实施例1Example 1	实施例2Example 2	实施例3Example 3	实施例4Example 4
氨甲环酸Tranexamic acid	0.1wt％0.1wt%	0.3wt％0.3wt%	0.2wt％0.2wt%	0.1wt％0.1wt%
绿原酸Chlorogenic acid	0.1wt％0.1wt%	0.3wt％0.3wt%	0.2wt％0.2wt%	0.3wt％0.3wt%
穿心莲提取物Andrographis extract	0.1wt％0.1wt%	0.3wt％0.3wt%	0.2wt％0.2wt%	0.1wt％0.1wt%
金银花提取物Honeysuckle extract	0.1wt％0.1wt%	0.3wt％0.3wt%	0.2wt％0.2wt%	0.3wt％0.3wt%
保湿剂moisturizer	10wt％10wt%	45wt％45wt%	10wt％10wt%	45wt％45wt%
表面活性剂Surfactant	2wt％2wt%	5wt％5wt%	2wt％2wt%	5wt％5wt%
甜味剂Sweetener	0.1wt％0.1wt%	0.5wt％0.5wt%	0.1wt％0.1wt%	0.5wt％0.5wt%
香料spices	0.1wt％0.1wt%	0.5wt％0.5wt%	0.1wt％0.1wt%	0.5wt％0.5wt%
清凉剂Cooling agent	0.1wt％0.1wt%	0.3wt％0.3wt%	0.1wt％0.1wt%	0.3wt％0.3wt%
防腐剂preservative	0.05wt％0.05wt%	0.2wt％0.2wt%	0.05wt％0.05wt%	0.2wt％0.2wt%

In this case, Porphyromonas gingivalis, P. intermedia, viscous actinomycetes, large intestine Five strains of bacillus and Staphylococcus aureus were tested for antibacterial activity with reference to Appendix C3 of GB 15979-2002.

Table 2 lists the results of the antibacterial experiments of Examples 1-4.

Table II

Although the embodiments of the present invention have been disclosed as above, they are not limited to the applications listed in the specification and the embodiments, and are fully applicable to various fields suitable for the present invention, and are easily accessible to those skilled in the art. The invention is not limited to the specific details and embodiments shown herein, without departing from the scope of the appended claims.

Claims

An antibacterial anti-inflammatory mouthwash characterized by using deionized water as a main component and adding at least a combination of tranexamic acid, chlorogenic acid, andrographis extract and honeysuckle extract.
The antibacterial anti-inflammatory mouthwash according to claim 1, wherein the tranexamic acid is contained in an amount of from 0.1 to 0.3% by weight.
The antibacterial anti-inflammatory mouthwash according to claim 1, wherein the chlorogenic acid is contained in an amount of from 0.1 to 0.3% by weight.
The antibacterial anti-inflammatory mouthwash according to claim 1, wherein the extract of Andrographis paniculata is 0.1 to 0.3% by weight.
The antibacterial anti-inflammatory mouthwash according to claim 1, wherein the honeysuckle extract is contained in an amount of 0.1 to 0.3% by weight.
The antibacterial anti-inflammatory mouthwash according to claim 1, further comprising a humectant, a surfactant, a sweetener, a flavor, a cooling agent, and a preservative.
The antibacterial anti-inflammatory mouthwash according to claim 6, wherein the humectant is selected from the group consisting of sorbitol, propylene glycol or a combination thereof; the humectant is contained in an amount of 10 to 45 wt%;

The surfactant is selected from sodium lauryl sulfate, poloxamer, polysorbate or a combination thereof; the surfactant is present in an amount of 2 to 5 wt%;

The sweetener is selected from the group consisting of saccharin, sodium saccharin, aspartame, stevioside, sucralose, xylitol or a combination thereof; the sweetener is present in an amount of 0.1 to 0.5% by weight;

The fragrance is selected from the group consisting of mint flavor, spearmint spice, green tea flavor, milk flavor, fruit a flavor or a combination thereof; the content of the fragrance is 0.1 to 0.5% by weight;

The cooling agent is selected from the group consisting of borneol, menthol or a combination thereof; the content of the cooling agent is 0.1 to 0.3% by weight;

The preservative is selected from the group consisting of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, methylparaben, propylparaben, butylparaben or a combination thereof; the content of the preservative is 0.05 to 0.2 Wt%.