WO2017181987A1 - 一种对多种症状具有功效的中药组合物及其衍生物和制品 - Google Patents

一种对多种症状具有功效的中药组合物及其衍生物和制品 Download PDF

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WO2017181987A1
WO2017181987A1 PCT/CN2017/081380 CN2017081380W WO2017181987A1 WO 2017181987 A1 WO2017181987 A1 WO 2017181987A1 CN 2017081380 W CN2017081380 W CN 2017081380W WO 2017181987 A1 WO2017181987 A1 WO 2017181987A1
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weight
parts
chinese medicine
traditional chinese
disease
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PCT/CN2017/081380
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English (en)
French (fr)
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张东
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张东
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Definitions

  • the invention relates to the technical field of traditional Chinese medicine, in particular to a multi-functional Chinese medicine composition and a derivative traditional Chinese medicine composition thereof which are born out of Sini Decoction.
  • Sini Decoction in "Treatise on Febrile Diseases”: "The licorice two two ( ⁇ ) dried ginger one and a half, one aconite (raw, peeled, broken eight), three flavors of water three liters, cook one liter two Hey, go to ⁇ , separate the temperature and serve again.” Used to return to the sun to save the fever, attending less yin and yin and cold. Regarding the indications of Sini Decoction, the following are recorded in "Treatise on Febrile Diseases”:
  • the self-interest is not thirsty, it is a yin, it is cold and dirty, and when it is warm, it should be served in the four generations (277)"
  • Sini Decoction According to the Eastern Han Dynasty “Treatise on Febrile Diseases", it mainly uses typhoid fever, cholera, and diarrhea. It is also the mainstream disease of Sini decoction in the later generations. According to the research results of Zhang Chengdong's "Research on the Ancient Application of Sini Decoction", the ancient literature records The application of Sini Decoction involves 158 symptoms, of which the first 10 symptoms with higher frequency are: cold hands and feet, sweat, diarrhea, abdominal pain, lower sputum, upper vomiting, upset, aversion to cold, retching Disgusting, further merging into the cold of the hands and feet, aversion to cold, sweat, abdominal pain, and vomiting five major diseases, reflecting the core symptoms of Sini Decoction.
  • Sini decoction uses high incidence of symptoms, including chest tightness, pus and blood, wheezing and coughing. It involves chest and yang, cold injury, kidney incontinence, cold and cold drinking, and other diseases. The development of the treatment of "Treatise on Febrile Diseases".
  • the derivation formula of Sini Decoction is endless, and its derivative formula uses 162 kinds of medicinal tastes, involving 20 kinds of drugs.
  • the most common in combination with warming medicine such as ginseng, atractylodes, cinnamon, alfalfa, pinellia, angelica, dried tangerine peel, magnolia, peony, asarum, belonging to spleen and qi, Wenli dispelling cold, benefiting Yin and nourishing,
  • warming medicine such as ginseng, atractylodes, cinnamon, alfalfa, pinellia, angelica, dried tangerine peel, magnolia, peony, asarum, belonging to spleen and qi, Wenli dispelling cold, benefiting Yin and nourishing.
  • Baitong Decoction, Baitong Plus Pork Bile Soup, Tongmai Sini Decoction and Qishen Decoction which are derived from it, are the main prescriptions for the treatment of heart and kidney deficiency, spleen and kidney yang deficiency and true winter fever syndrome. According to the known derivative series, it is speculated that Sini Decoction can be further excavated to develop new derivative formulas and wider indications.
  • the invention provides a pharmaceutical composition and a product thereof, which are born out of the classic Fangsi Decoction, but the meaning of the prescription is that the scope of the application is completely different from the Sini Decoction.
  • a traditional Chinese medicine composition having efficacy against various symptoms characterized in that it is composed of 2-6 parts by weight of the drug substance A, 0-1.5 parts by weight of the drug substance B and 1 part by weight of the drug substance C;
  • the drug substance A is licorice, raw licorice, jujube and/or glutinous rice;
  • the drug substance B is dried ginger or gun ginger;
  • the drug substance C is an aconite
  • the plurality of symptoms include the plurality of symptoms including coronary heart disease, hyperlipidemia, arrhythmia, heart failure, hypertension, type II diabetes, cardiac neurosis, skin disease, menstrual disease, painful disease, constipation Insomnia, cervical vertebrae, lumbar spondylosis, cold, chronic bronchitis, human papillomavirus infection, hyperthyroidism, neurological tremor, nocturnal emission, impotence, ADHD, depression, menopausal syndrome, chronic colitis, chronic gastritis, reflux Esophagitis, tumor rehabilitation, peripheral neuropathy, chronic urinary infection, allergic disease, herpes zoster, cerebrovascular disease, blood disease.
  • the traditional Chinese medicine composition comprises 2 parts by weight of the drug substance A, 1 to 1.5 parts by weight of the drug substance B, and 1 part by weight of the drug substance C.
  • the traditional Chinese medicine composition comprises 3-6 parts by weight of the drug substance A, 1-1.5 parts by weight of the drug substance B and 1 part by weight of the drug substance C.
  • a traditional Chinese medicine composition obtained by adding any one of the following auxiliary auxiliary medicines to any of the above traditional Chinese medicine compositions:
  • Rhizoma Rhizoma 0.6-1.5 parts by weight
  • Cistanche deserticola 0.6-1.5 parts by weight
  • the mantle is 0.6-1.5 parts by weight and the corner angle is 0.6-1.5 parts by weight;
  • Tortoise shell rubber 0.6-1.5 parts by weight
  • Hazelnuts 0.6-1.5 parts by weight
  • the traditional Chinese medicine product is characterized in that the dosage form is an oral decoction, a powder, a granule, a pill, an extract, and an external dosage form.
  • the traditional Chinese medicine product is characterized by further comprising a pharmaceutically acceptable excipient for preparing a desired dosage form.
  • the method for preparing the above-mentioned traditional Chinese medicine product comprises the steps of: decoying the raw material medicine to obtain a traditional Chinese medicine water extract liquid.
  • the method further comprises first boiling the aconite for at least 15 minutes, and then adding the remaining bulk drug for boiling.
  • the method for preparing a traditional Chinese medicine product comprising the steps of: first boiling the aconite for at least 15 minutes, and then adding the remaining bulk drug; the ratio of the amount of water added to the boiling is each dose of the drug. 300-800 ml, each time boiling for 20-30 minutes, add water 2-3 times, go to the slag and combine the boiling liquid.
  • the traditional Chinese medicine composition provided by the invention is taken as "Guiyiyin", and the main raw material medicine is composed of licorice and/or jujube, dried ginger and aconite in a ratio of 2-3:1 to 1.5:1. It was born out of Sini Decoction ("Glycyrrhiza sinensis ( ⁇ ) dry ginger one and a half, aconite one"), but the principle and intention of the prescription is completely different from Sini Decoction.
  • the traditional Chinese medicine composition of the present invention or its product replaces the raw aconite of Sinitang with the aconite, and uses a small amount, and the purpose is not to smother the cold, but to take less fire and anger, and make aconite
  • the lack of fire is not just for kidney yang, it is to repair the center of the heart, repairing the center of the heart is not just to restore the spleen and stomach, but to repair the acquired vitality.
  • the traditional Chinese medicine composition (Guiyiyin) is a medicinal herb of licorice, jujube and/or fried glutinous rice, and the dose is the largest, and the ginger is connected with aconite and licorice, and the root and the center of the heart are connected, although it is adjuvant, But its role is indispensable; the system of aconites is less angry, and the machine that starts the growth is the minister.
  • Mr. Li Ke Lao in the field, the effect of raw aconite is two to three times that of aconite, that is, one aconite is generally 15-20 grams, and the efficacy is about 40-60 grams of aconite.
  • the invention replaces the raw aconite in the Sini Decoction with the aconite. At this time, it can no longer be called Sini Decoction, because the main effect of the traditional Chinese medicine composition (Guiyiyin) is not only to return to the sun for reversal.
  • aconite such as Sini Decoction, Tongmai Sini Decoction, Baitong Decoction, Sui Sini Decoction, Dried Ginger Fuzi Soup, etc., while the aconite is used in Wenyang.
  • Kidney warm and wet, such as Zhenwu Tang, Fuzi Tang, Guizhi Fuzi Tang and so on. From the traditional Chinese medicine processing system, it is generally the mature product partial compensation, the raw products are diarrhea; the raw products are more scattered, and the cooked products are more concentrated.
  • Sini Decoction is mainly used for reversing the yang and reversing the symptoms of yin and yin deficiency. It is divided into five major diseases: cold hands and feet, cold, sweat, abdominal pain and vomiting. .
  • the Guiyiyin indication of the present invention is more extensive than Sinitang.
  • the core drug substance group of the traditional Chinese medicine composition of the present invention is clinically suitable for various diseases such as coronary heart disease, hyperlipidemia, arrhythmia, heart failure, hypertension.
  • Type 2 diabetes cardiac neurosis, skin disease, menstrual disease, painful disease, constipation, insomnia, cervical vertebrae, lumbar spondylosis, cold, chronic bronchitis, human papillomavirus infection, hyperthyroidism, neurological tremor, nocturnal emission, Impotence, pediatric ADHD, depression, menopausal syndrome, chronic colitis, chronic gastritis, reflux esophagitis, tumor rehabilitation, peripheral neuropathy, chronic urinary infection, allergic disease, herpes zoster, cerebrovascular disease, blood Liquid disease, etc.
  • the multi-functional Chinese medicine composition provided by the present invention is born out of Sini Decoction, but the indication is more extensive than Sini Decoction, and the medicine is mild and safe, and belongs to all patients except severe yin deficiency and simple heat syndrome patients. Health products that people can take.
  • the licorice, the jujube and the fried glutinous rice can be used interchangeably or in combination, and in particular, for patients who are contraindicated with licorice, the jujube or fried glutinous rice can be completely used, which makes the traditional Chinese medicine composition of the invention
  • the adaptation of (Guiyiyi) is more extensive and safe.
  • the clinical practice case proves that the multi-effect traditional Chinese medicine composition of the invention can be combined with a plurality of commonly used raw material medicines to obtain a more targeted and superior formula for specific indications. According to clinical experimental examples, at least the effect of each formula is verified and verified. From 10 cases, some hundreds of cases, as follows:
  • Adding red yeast rice has better effect on hyperlipidemia, and the course of treatment is 2-3 months;
  • Jiayujin has a better effect on cardiac neurosis, and the course of treatment
  • Jiazizi and Epimedium are better for type 2 diabetes (2-3 months) and insomnia (1-2 months).
  • Ephedra and almonds have a more obvious effect on cough, and the effect is 1-2 weeks;
  • Cinnamon a better treatment for dysmenorrhea for 4 weeks
  • Hawthorn has a better therapeutic effect for liver and kidney for 4 weeks;
  • Rehmannia glutinosa has a better therapeutic effect on liver and kidney for 4 weeks;
  • Rehmannia glutinosa has a better therapeutic effect on liver and kidney for 4 weeks;
  • Pangolin has a better therapeutic effect for Huoxuetongluo for 4 weeks;
  • Ginseng a better course of treatment for qi for 4 weeks
  • Clematis has a better course of treatment for pain relief and gout for 4 weeks;
  • Suanzaoren has a better therapeutic effect on insomnia for 4 weeks
  • Gynostemma pentaphyllum has a better therapeutic effect for the treatment of hyperlipidemia for 4 weeks;
  • Aster has a better therapeutic effect for the treatment of cough for 4 weeks;
  • Antler gum has a better therapeutic effect for tonifying the kidney and treating blood diseases for 12 weeks;
  • Turtle board glue has a better curative effect for tonifying kidney and treating blood diseases for 12 weeks;
  • Peach kernel has a better therapeutic effect for the treatment of promoting blood circulation and removing blood stasis for 12 weeks;
  • Dilong has a better therapeutic effect on cardiovascular disease for 12 weeks;
  • Dodder has a better therapeutic effect for tonifying the kidney and treating blood diseases for 12 weeks;
  • Cynomorium has a better therapeutic effect for tonifying the kidney and treating blood diseases for 12 weeks;
  • Distraction wood a better treatment for senile urinary incontinence for 4 weeks;
  • the above multi-effect traditional Chinese medicine composition of the present invention can also be combined with Musk and Perrin; Radix and Radix;
  • the traditional Chinese medicine composition of the present invention needs to be boiled before being taken. Therefore, the preparation of the traditional Chinese medicine composition of the present invention, in the preparation method thereof, includes the step of boiling the raw material medicine in the counterpart agent.
  • the aconite is first decocted for at least 15 minutes, preferably at least 30 minutes, preferably 1 hour. Then add the remaining two raw materials to decoction to obtain a decoction.
  • the Chinese patent medicine is prepared, it is preferably an oral decoction, a powder, a granule, a pill or an external preparation, but is not limited thereto.
  • RAD ⁇ is a leguminous plant
  • licorice is a licorice baked with honey, commonly known as concoction, is to put the honey in the pot into a medium honey, use the simmer and add licorice tablets to mix evenly, 3 ⁇ 5min out of the pot, set the baking room or oven 60 ⁇ C to dry until not sticky, take off, let cool.
  • Licorice, scientific name: Glycyrrhiza uralensis Fisch leguminous, licorice is a perennial herb, the medicinal parts are roots and rhizomes, the roots of the medicinal properties are cylindrical, 25 to 100 cm long and 0.6 to 3.5 cm in diameter.
  • Zhigancao Decoction has the effect of nourishing qi and nourishing yin and Tongyang Fumai.
  • Jujube It has the function of nourishing yin and nourishing yang.
  • Dried ginger dried roots of the ginger family Zingiber oj-jicinale Rosc. It has the effect of warming and dispelling cold, returning to the yang, and warming the lungs.
  • Aconite It is the root of Aconitum carmichaeli Debx., which is removed from the roots, roots and sediments of the genus Ranunculaceae. It is reduced in toxicity after salting, water bleaching, boiling and frying. It has the effect of rejuvenating back to the sun, supplementing the fire and helping the yang, and relieving the wind and cold dampness. It is used for the devastation of the dead yang, cold limbs of the limbs, impotence, cold, chills, cold and vomiting, cold and edema, yang deficiency, Cold and wet pain.
  • Fried glutinous rice glutinous rice, Latin name: Coix chinensis Tod. Also called: ⁇ , ⁇ , ⁇ , the seed of the grass family, fried glutinous rice is fried glutinous rice.
  • Nepeta Alias: fragrant scorpion, scorpion scorpion, quadruple stalk, sinus, is a perennial plant of the family Labiatae and Nepeta. Into its medicinal dry stems and ears.
  • Windproof The root of the umbrella-shaped plant.
  • Red yeast rice using glutinous rice as raw material, using modern bioengineering technology to separate high quality Monascus (monascuspureus) is a pure natural, safe and beneficial food additive for human health.
  • Triangular dry tubers of the black-triangular plant Sparganium stoloni erum, Buch.–Ham.
  • Curcuma dried rhizome of Curcuma phaeocaulis Val., Curcuma Kwangsiensis S.G.Lee et C.F.Liang or Curcuma wenyujin Y.H.Chen et C.Ling
  • Alisma Alisma plantago-aquatica Linn. Perennial aquatic or marsh herb.
  • Zeeland It is the dry upper part of the sweet potato plant of the Labiatae or the sweet potato of the hairy leaf.
  • Yujin dry roots of the genus Curcuma rcenyujin Y, H.Chenet C.Ling, Curcuma longaL., Curcumakwangsiensis S.G.Lee et C.F.Liang or Curcuma pha eocaulis Val.
  • Bayu Tian Scientific name: Morinda officinalis How, is the dry root of the dicotyledonous plant.
  • Epimedium Scientific name: Epimedium brevicornu Maxim. Perennial herb whole grass.
  • Pueraria the dry root of the leguminous kudzu
  • Eupatorium aponic Turcz. The Latin name Eupatorium aponic Turcz. is the compositae Peland (bluegrass), which is used as a whole herb.
  • Sand ginseng Latin name: Adenophora stricta Miq.] Campanulaceae is a perennial herb with roots.
  • Ophiopogon japonicus Ophiopogon aponicas (Linn.F.) Ker-Gawl.) The roots of perennial evergreen plants of the genus Liliaceae.
  • Persimmon dry scorpion of persimmon plant Diospyros kaki Thunb.
  • ⁇ God Hold the pine roots for the center of the day.
  • Xinyi The flower bud of magnolia.
  • Xanthium the fruit of the common amaranth of the genus Asteraceae, a genus of the genus Asteraceae, of the genus Asteraceae.
  • Cyclobalanopsis Asteraceae Cyclobalanopsis, also known as: Golden Boiling Grass, Money Flower, Drip Gold, Bandit, Xia Ju, Dai Dai, dry flowers into medicine.
  • Meteorite Ore of oxide mineral hematite.
  • Mantle Latin name: Sanguisorba officinalis L. is the root of a perennial herb of the genus Rosaceae.
  • Corydalis yanhusuo W.T.Wang ex Z.Y.Su et C.Y.Wu also known as Yanhu, Xuanhusuo, Yuanhusuo, Yuanhu and so on. It is a tuber of perennial herb of Papaveraceae and Aster.
  • Safflower safflower, (Latin name: Carthamus tinctorius L.), alias: red blue flower, thorn safflower, Compositae, safflower, dried tubular flower medicine.
  • Aster Scientific name: Aster tataricus L.f., alias: Qingyuan, Ziqian, Xiaoyan, etc.; Asteraceae, a perennial herbaceous rhizome.
  • Coltsfoot the flower bud of the Tussilago farfara L.
  • Ephedra dry grass stem of Ephedra, Ephedra or Ephedra
  • Red ginseng is a cooked food of ginseng, and its processing method is processed by infiltration, washing, sorting, steaming, drying, drying and other processes.
  • the first embodiment is equivalent to an oral preparation prepared by using "Glycyrrhiza uralensis 20g, dried ginger 15g, and aconite 10g" as a raw material medicine.
  • the rest of the embodiments are deduced by analogy.
  • dried ginger can be replaced with gun ginger.
  • Table 2 in the formula 1-16 the weight value range of each flavor drug is used in the prescription of outpatient treatment, for example, 2-6 parts by weight of licorice, 2 parts by weight, 2.1 parts by weight, 2.2 Parts by weight, 2.3 parts by weight, 2.4 parts by weight, 2.5 parts by weight, 2.6 parts by weight, 2.7 parts by weight, 5.5 parts by weight, 5.6 parts by weight, 5.7 parts by weight, 5.8 parts by weight, 5.9 parts by weight, and 6 parts by weight are used;
  • 1-1.5 parts by weight of dried ginger means 1 part by weight, 1.1 parts by weight, 1.2 parts by weight, 1.3 parts by weight, and 1.4 parts by weight of 1.5 parts by weight;
  • the multi-functional Chinese medicine composition provided by the present invention is born out of Sini Decoction, but the indication is more extensive than Sini Decoction. Mild and safe, it is a traditional Chinese medicine composition that can be taken by all patients except severe yin deficiency and simple heat syndrome patients; on the other hand, based on the multi-functional Chinese medicine composition, Appropriate amount of the drug substance corresponding to the symptom can obtain a targeted drug prescription for different diseases with remarkable curative effect.

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Abstract

一种对多种症状具有功效的中药组合物，其特征在于由2-6重量份的原料药A、1-1.5重量份的原料药B和1重量份的原料药C组成；所述原料药A为炙甘草、生甘草、大枣和/或薏米，所述原料药B为干姜或炮姜；所述原料药C为制附子。该中药组合物还可以与多种中药配合衍生出适应不同症状的中药组合物。

Description

一种对多种症状具有功效的中药组合物及其衍生物和制品 技术领域
本发明涉及中医药技术领域，特别是一种脱胎于四逆汤的多功效中药组合物及其衍生中药组合物。
技术背景
《伤寒论》中记载有四逆汤：“甘草二两(炙)干姜一两半,附子一枚(生用，去皮，破八片)，上三味以水三升，煮取一升二合，去滓，分温再服”。用于回阳救逆，主治少阴病阴寒内盛证。关于四逆汤的适应症，《伤寒论》中有如下记载：
“伤寒，医下之，续得下利清谷不止，身疼痛者，急当救里；后身疼痛，清便自调者，急当救表。救里，宜四逆汤；救表，宜桂枝汤；(91)”。
“病发热头痛，脉反沉，若不差，身体疼痛，当救其里，四逆汤方。(92)”
“脉浮而迟，表热里寒，下利清谷者，四逆汤主之。(225)”
“自利不渴者，属太阴，以其脏有寒故也，当温之，宜服四逆辈(277)”
“少阴病，脉沉者，急温之，宜四逆汤。(323)”
“大汗出，热不去，内拘急，四肢疼，又下利厥逆而恶寒者，四逆汤主之。(352)”
“大汗，若大下利而厥冷者，四逆汤主之。(353)”
“下利，腹胀满，身体疼痛者，先温其里，乃攻其表。温里，宜四逆汤；攻表，宜桂枝汤。(371)”
“呕而脉弱，小便复利，身有微热，见厥者难治，四逆汤主之(376)”
“吐利汗出，发热恶寒，四肢拘急，手足厥冷者，四逆汤主(388)”
“既吐且利，小便复利而大汗出，下利清谷，内寒外热，脉微欲绝者，四逆汤主之。(389)”
根据东汉《伤寒论》，其主要用伤寒、霍乱、泄泻，也是后世历代运用四逆汤的主流病种，根据张成东的《四逆汤古代运用的文献研究》记载的研究结果，古代文献记载四逆汤运用涉及158个症状，其中出现频率较高的前10个症状依次是：手足厥冷、汗多、泄泻、腹痛、下利清谷、上吐下利、心烦、恶寒、干呕、恶心，进一步归并为手足厥冷、恶寒、汗多、腹痛、吐利五大症，反映出四逆汤证的核心症征。四逆汤运用涉及症状出现率较高的还有胸闷，便下脓血，喘息和咳嗽症，涉及胸阳不振，寒伤肠络，肾不纳气和寒饮犯肺等病机，是源于《伤寒论》主治的发展。
四逆汤的派生配方层出不穷，其派生配方运用涉及药味共计162种，涉及20类药物， 其中以与温补药配伍最为多见，例如人参、白术、肉桂、茯苓、半夏、当归、陈皮、厚朴、芍药、细辛，归属健脾益气、温里散寒、益阴养血、理气化痰四类。但是四逆汤原方配伍在东汉用生附子、干姜，晋唐以降至明则倾向于炮附子替用生附子，干姜与炮干姜互用，但至清朝则有回归之早期的主用生附子和干姜的倾向，历朝四逆汤中均用炙甘草。
可以看出，四逆汤组方精妙，法度严谨，为历代医家所推崇，是出自《伤寒论》治疗少阴寒化证的经典名方，随着临床的发展和用方经验的积累，该方已被广泛于临床各科，成为现代古方新用的重要方剂之一，国内已经有学者用现代科学方法和设备，从物质基础角度去探索和阐明其组方原理及科学内涵，揭示各药味在方中的作用。由其派生的白通汤、白通加猪胆汁汤、通脉四逆汤、茯苓四逆汤等，为中医治疗心肾虚、脾肾阳虚、真寒假热证的系列要方。根据已知派生的系列药方可以推测，还可以对四逆汤进行进一步挖掘，开拓新的派生配方以及其更宽的适应症。
发明内容
本发明提供一种药物组合物及其制品，其脱胎于经典方四逆汤，但其组方含义，适用症范围完全不同于四逆汤。
本发明提供的技术方案如下：
一种对多种症状具有功效的中药组合物，其特征在于,由2-6重量份的原料药A，0-1.5重量份的原料药B和1重量份的原料药C组成；
所述原料药A为炙甘草、生甘草、大枣和/或薏米；
所述原料药B为干姜或炮姜；
所述原料药C为制附子；
所述多种症状包括所述多种症状包括冠心病、高脂血症、心律失常、心力衰竭、高血压病、Ⅱ型糖尿病、心脏神经官能症、皮肤病、月经病、疼痛性疾病、便秘、失眠、颈椎、腰椎病、感冒、慢性支气管炎、人乳头瘤病毒感染、甲亢、神经性震颤、遗精、阳痿、小儿多动症、抑郁症、更年期综合征、慢性结肠炎、慢性胃炎、反流性食道炎、肿瘤康复、周围神经病、慢性泌尿性感染、过敏性疾病、带状疱疹、脑血管病、血液病。
优选地，所述的中药组合物，由2重量份的原料药A，1-1.5重量份的原料药B和1重量份的原料药C。
优选地，所述的中药组合物，由3-6重量份的原料药A，1-1.5重量份的原料药B和1重量份的原料药C。
一种中药组合物，是上述任一中药组合物中添加以下任一组辅助原料药而得：
荆芥和防风；红曲；三棱和莪术；泽泻和泽兰；郁金；巴戟天；枸杞子和淫羊藿；巴戟天和淫羊藿；葛根；藿香和佩兰；沙参和麦冬；黄芪；白术；茯神；半夏；肉苁蓉；杜仲和牛膝；丁香和柿蒂；茯苓和泽泻；辛夷和苍耳子；
旋复花和代赭石；天麻；地榆和槐角；延胡索；红花和益母草；土茯苓；紫苑和款冬；麻黄和杏仁；半夏和桔梗；射干和麻黄；当归；丹参和红花；麦冬和五味子；红参；郁金和合欢花；合欢花；黄芪、女贞子和补骨脂；蜜麻黄或生麻黄；阿胶；当归；白芍；片姜黄；细辛；肉桂；伸筋草；巴戟天；山茱萸；熟地黄；生地黄；穿山甲；龟板；鳖甲；党参；人参；三七；木香；威灵仙；水蛭；全蝎；蜈蚣；合欢皮；酸枣仁；枳实；绞股蓝；黄杨宁；紫苑；鹿角胶；龟板胶；桃仁；地龙；枳椇子；菟丝子；锁阳。
所述的中药组合物，其特征在于，其中，所述辅助原料药的重量份为：
荆芥0.6-1.5重量份和防风0.6-1.5重量份；
红曲0.6-1.5重量份；
三棱0.6-1.5重量份和莪术0.6-1.5重量份；
泽泻0.6-1.5重量份和泽兰0.6-1.5重量份；
郁金0.6-1.5重量份；
巴戟天0.6-1.5重量份；
枸杞子0.6-1.5重量份和淫羊藿0.6-1.5重量份；
巴戟天0.6-1.5重量份和淫羊藿0.6-1.5重量份；
葛根0.8-1.2重量份；
藿香0.6-1.5重量份和佩兰0.6-1.5重量份；
沙参0.6-1.5量重量份和麦冬0.6-1.5重量份；
黄芪0.6-1.5重量份；
白术0.6-1.5重量份；
茯神0.6-1.5重量份；
半夏0.6-1.5重量份；
肉苁蓉0.6-1.5重量份；
杜仲0.6-1.5重量份和牛膝0.6-1.5重量份；
丁香0.6-1.0重量份和柿蒂0.6-1.0重量份；
茯苓0.6-1.5重量份和泽泻0.6-1.5重量份；
辛夷0.6-1.0重量份和苍耳子0.6-1.0重量份；
旋复花0.6-1.5重量份和代赭石重0.6-3量重量份；
天麻0.6-2重量份；
地榆0.6-1.5重量份和槐角0.6-1.5重量份；
元胡0.6-1.5重量份；
红花0.6-1.5重量份和益母草0.6-1.5重量份；
土茯苓0.6-1.5重量份；
紫苑0.6-1.5重量份和款冬0.6-1.5重量份；
麻黄0.6-1.0重量份和杏仁0.6-1.5重量份；
半夏0.6-1.5重量份和桔梗0.6-1.5重量份；
射干0.6-1.5重量份和麻黄0.6-1.0重量份；
当归0.6-1.5重量份；
丹参0.6-1.5重量份和红花0.6-1.5重量份；
麦冬0.6-1.5重量份和五味子重0.6-1.5量重量份；
红参0.6-1.5重量份；
郁金0.6-1.5重量份和合欢花0.6-1.5重量份；
合欢花0.6-1.5重量份；
黄芪0.6-1.5重量份、女贞子0.6-1.5重量份、补骨脂0.6-1.5重量份；
蜜麻黄或生麻黄0.6-1.5重量份；
阿胶0.6-1.5重量份；
当归0.6-1.5重量份；白芍0.6-1.5重量份；
片姜黄0.6-1.5重量份；
细辛0.3-0.6重量份；
肉桂0.6-1.5重量份；
伸筋草0.6-1.5重量份；
巴戟天0.6-1.5重量份；
山茱萸0.6-1.5重量份；
熟地黄0.6-1.5重量份；
生地黄0.6-1.5重量份；
穿山甲0.6-1.5重量份；
龟板0.6-1.5重量份；
鳖甲0.6-1.5重量份；
党参0.6-1.5重量份；
人参0.6-1.5重量份；
三七0.6-1.5重量份；
木香0.6-1.5重量份；
威灵仙0.6-1.5重量份；
水蛭0.6-1.5重量份；
全蝎0.6-1.5重量份；
蜈蚣0.6-1.5重量份；
合欢皮0.6-1.5重量份；
酸枣仁0.6-1.5重量份；
枳实0.6-1.5重量份；
绞股蓝0.6-1.5重量份；
黄杨宁0.6-1.5重量份；
紫苑0.6-1.5重量份；
鹿角胶0.6-1.5重量份；
龟板胶0.6-1.5重量份；
桃仁0.6-1.5重量份；
地龙0.6-1.5重量份；
枳椇子0.6-1.5重量份；
菟丝子0.6-1.5重量份；
锁阳0.6-1.5重量份；
分心木0.6-1.5重量份；
一种中药制品，其特征在于，由所述的对多种症状具有功效的中药组合物或所述的中药组合物为原料制成。
所述的中药制品，其特征在于，剂型为口服汤剂、散剂、颗粒剂、丸剂、提取液、外用剂型。
所述的中药制品，其特征在于，还包含用于制备所需剂型的药学上可接受的辅料。
上述中药制品的制备方法，其特征在于，包括对所述原料药进行煎煮制得中药水提取液。
优选地，还包括对所述制附子先煎煮至少15分钟，然后再加入其余原料药进行煎煮。
任一所述的中药制品的制备方法，其特征在于，包括如下步骤：对所述制附子先煎煮至少15分钟，然后加入其余原料药；煎煮所加水量比例为为每剂药每次300-800毫升，每次煎煮20-30分钟，加水2-3次，去渣合并煎煮液。
本发明提供的中药组合物，药名取为“归一饮”，主要原料药由炙甘草和/或大枣、干姜、制附子以2-3:1-1.5:1的比例组成。其脱胎于四逆汤(“甘草二两(炙)干姜一两半,附子一枚”)，但组方原理和用意完全不同于四逆汤。而本发明中药组合物或其制品(归一饮)将四逆汤的生附子换成了制附子，且用小量，用意不在祛寒邪，而是取少火生气之意，而且制附子辛散中又有固敛之意。而少火生气不是只为了补肾阳，是为了修复圆心，修复圆心不只是恢复脾胃之气，而是为了修复后天元气。因此本发明中药组合物(归一饮)是以炙甘草、大枣和/或炒薏米为君药，且剂量最大，干姜连接制附子和甘草，连接天根与圆心，虽为佐使，但其作用不可或缺；制附子少火生气，启动生长之机，是为臣。按本领域李可老先生的经验，生附子的药效是制附子的两到三倍，即生附子一枚一般有15-20克，药效上约相当于制附子40-60克，这也是李可老先生的著作中记载的用大剂量制附子的理论基础之一，因此要起到《伤寒论》四逆汤祛少阴阴寒、回阳救逆的作用，换作采用制附子的话，四逆汤的配比则为制附子40-60g、干姜24g、炙甘草32g(按汉代的一两等于现代的15.625g算)，可以看出，制附子反而是最大剂量的，是君药。而本发明归一饮中制附子的剂量是最小的，仅仅是臣药，这说明本发明的归一饮的方剂用意与四逆汤完全不同。
本发明是把四逆汤中的生附子换为了制附子，这时就已经不能再称其为四逆汤，因为中药组合物(归一饮)的主要作用不只是回阳救逆。本领域技术人员知道，生附子和制附子的作用并不完全一样。仲景凡取回阳救逆之功则用生附子，如四逆汤、通脉四逆汤、白通汤、茯苓四逆汤、干姜附子汤等等；而制附子则多用于温阳补肾、温经逐湿，如真武汤、附子汤、桂枝附子汤等等。从中药炮制上讲，一般是熟品偏补，生品偏泻；生品多偏散，熟品多偏固敛。如生地黄和熟地黄，《本草纲目》说“地黄生则大寒，而凉血，血热者需用之，熟则微温，而补肾，血衰者需用之”。再如生甘草和炙甘草、生白术和炒白术、生白芍和炒白芍、生首乌与熟首乌等等。因此相对于生附子，制附子多有固阳﹑攝阳之功，这也是后世用之引火归元的原因之一。而即使是制附子，因其剂量不同，用意也不同，如温经逐湿多用两枚甚至三枚，如附子汤、桂枝附子汤；温阳补肾，多用一枚如真武汤、桂枝加附子汤，这是少火生气之意。
从适应症方面，从古书记载看出，四逆汤主要用于回阳救逆，主治少阴病阴寒内盛证，归并为手足厥冷、恶寒、汗多、腹痛、吐利五大症。而本发明的归一饮适应症比四逆汤更广泛，临床观察本发明的中药组合物的核心原料药组方适合诸多病症如冠心病、高脂血症、心律失常、心力衰竭、高血压病、Ⅱ型糖尿病、心脏神经官能症、皮肤病、月经病、疼痛性疾病、便秘、失眠、颈椎、腰椎病、感冒、慢性支气管炎、人乳头瘤病毒感染、甲亢、神经性震颤、遗精、阳痿、小儿多动症、抑郁症、更年期综合征、慢性结肠炎、慢性胃炎、反流性食道炎、肿瘤康复、周围神经病、慢性泌尿性感染、过敏性疾病、带状疱疹、脑血管病、血 液病等。仅只不适合于肾之储备不够的患者、阴虚阳亢的患者，另外，对于全身性的热毒炽盛，尤其热入营血的症候也不适合。即本发明提供的多功效中药组合物本身，脱胎于四逆汤，但适应症比四逆汤更广泛，药效温和安全，属于除了严重阴虚的患者以及单纯实热证患者之外，所有人都可以服用的保健制品。
本发明的中药组合物中，炙甘草、大枣、炒薏米可以互换或者混合使用，特别是对于炙甘草有禁忌的患者，可以完全采用大枣或炒薏米，这使得本发明的中药组合物(归一饮)的适应范围更为广泛和安全。临床实践案例证明，本发明多效中药组合物可以与多种常用原料药组合，得到对具体适应症更具有针对性和更优的配方，根据临床实验例，每种配方的效果观察验证数据至少来自于10例病例，有些上百例，具体如下：
加荆芥和防风，对皮疹的疗效更好，疗程2-3周；
加红曲对高脂血症效果更优，疗程2-3个月；
加三棱和莪术对冠心病效果更优，疗程3-6个月；
加泽泻和泽兰对心力衰竭疗效更好，疗程3－10个月；
加郁金对心脏神经官能症效果更好，疗程；
加巴戟天，对抑郁症疗效更好，疗程2-3个月；
加枸杞子和淫羊藿对Ⅱ型糖尿病(2-3个月)、失眠(1-2疗程个月)效果更好。
加巴戟天和淫羊藿，对Ⅱ型糖尿病效果更好，疗程2-3月；
加葛根，对颈椎病效果突出，疗程2-3周
加杜仲和牛膝，对腰椎病疗效更好，疗程2-3周；
加地榆和槐角，对痤疮，痔疮疗效显著，疗程2-3周
加延胡索，对心律失常效果更优，疗程2-3个月；
加茯神更有益于缓解失眠，疗程1－2个月；
加紫苑和款冬对咳嗽效果更明显，疗效1-2周；
麻黄和杏仁对咳嗽效果更明显，疗效1-2周；
半夏和桔梗；对咳嗽效果更明显，疗效1-2周；
加天麻，对于头晕有更好的疗效疗程2-3周；
加蜜麻黄或生麻黄，对于缓慢性心律失常有更好的疗效疗程4周；
加阿胶，对于安胎有更好的疗效疗程4-12周；
加当归，白芍，对于血虚有更好的疗效疗程4周；
加片姜黄，对于肩背痛有更好的疗效疗程4周；
加细辛，对于止痛有更好的疗效疗程4周；
肉桂，对于痛经有更好的疗效疗程4周；
伸筋草，对于肌肉痉挛有更好的疗效疗程4周；
山茱萸，对于补肝肾有更好的疗效疗程4周；
熟地黄，对于补肝肾有更好的疗效疗程4周；
生地黄，对于补肝肾有更好的疗效疗程4周；
穿山甲，对于活血通络有更好的疗效疗程4周；
龟板，对于补肝肾有更好的疗效疗程4周；
鳖甲，对于补肝肾活血有更好的疗效疗程4周；
党参，对于健脾有更好的疗效疗程4周；
人参，对于补气更好的疗效疗程4周；
三七，对于活血化瘀有更好的疗效疗程4-24周；
大腹皮，对于治疗肠胃炎有更好的疗效疗程4周；
威灵仙，对于止痛、痛风有更好的疗效疗程4周；
水蛭，对于活血化瘀治疗心血管疾病有更好的疗效疗程4-12周；
全蝎，对于止痛有更好的疗效疗程4周；
蜈蚣；对于止痛有更好的疗效疗程4周；；
合欢皮，对于失眠有更好的疗效疗程4周；
酸枣仁，对于失眠有更好的疗效疗程4周；
枳实，对于治疗肠胃炎有更好的疗效疗程4周；
绞股蓝，对于治疗高脂血症有更好的疗效疗程4周；
黄杨宁，对于治疗心律失常更好的疗效疗程4周；
紫苑，对于治疗咳嗽有更好的疗效疗程4周；；
鹿角胶，对于补肾、治疗血液病有更好的疗效疗程12周；
龟板胶，对于补肾、治疗血液病有更好的疗效疗程12周；
桃仁，对于活血化瘀治疗有更好的疗效疗程12周；
地龙，对于心血管病有更好的疗效疗程12周；
枳椇子，对于治疗肝病有更好的疗效疗程12周；
菟丝子，对于补肾、治疗血液病有更好的疗效疗程12周；
锁阳，对于补肾、治疗血液病有更好的疗效疗程12周；
分心木，对于老年性小便失禁有更好的疗效疗程4周；
根据临床使用案例，本发明的上述多效中药组合物还可以与藿香和佩兰；沙参和麦冬；
黄芪；白术；半夏；肉苁蓉；丁香和柿蒂；茯苓和泽泻
辛夷和苍耳子；旋复花和代赭石；合欢花；黄芪、女贞子和补骨脂
或红花和益母草的组合得到具有不同侧重疗效的方剂；
本发明的中药组合物，都需要煎煮后才能服用。因此本发明的中药组合物的制品，在其制备方法中，都包括对方剂中的原料药进行煎煮的步骤。
在进一步优选的方案中，对制附子进行先煎煮，至少15分钟，优选至少30分钟，最好1个小时。然后再加入其余两味原料药进行煎煮制得汤剂。
本发明请求保护的中药组合物的制品，无论做成什么剂型，都可以采用本领域常规技术手段来现实，包括采用一些常规的辅料来做成各种所需的剂型。
在做成中成药的实施方案中，优选做成口服汤剂、散剂、颗粒剂、丸剂或外用剂型，但不限于此。
本发明的所有方案中采用的原料药在一般中药房都可以买到，其中，部分原料药简介如下：
炙甘草：(RADIX GLYCYRRHIZAE PREPARATA)，系豆科植物，炙甘草是用蜜烘制的甘草，俗称炮制，就是将蜂蜜置锅中炼成中蜜，改用文火加生甘草片拌炒均匀，3～5min出锅，置烤房或烘箱60～C烘至不粘手时取出，放凉即可。甘草，学名：Glycyrrhiza uralensis Fisch，豆科、甘草属多年生草本，药用部位是根及根茎，药材性状根呈圆柱形，长25～100厘米，直径0.6～3.5厘米。炙甘草汤具有益气滋阴，通阳复脉治疗功效。
大枣：具有滋阴补阳，补血之功
干姜：为姜科植物姜Zingiber oj-jicinale Rosc.的干燥根茎。具有温中散寒，回阳通脉，温肺化饮的功效。
制附子：为毛茛科植物乌头Aconitum carmichaeli Debx.的子根，除去母根、须根及泥沙，经盐渍、水漂、煮、炒等法炮制后降低毒性。具有回阳救逆，补火助阳，逐风寒湿邪的功效，用于亡阳虚脱，肢冷脉微，阳痿，宫冷，心腹冷痛，虚寒吐泻，阴寒水肿，阳虚外感，寒湿痹痛。
炒薏米：薏米，拉丁文名：Coix chinensis Tod.又叫：薏苡仁、苡仁、六谷子，为禾本科植物薏苡的种仁，炒薏米为炒熟的薏米。
荆芥：别名：香荆荠、线荠、四棱杆蒿、假苏，是唇形科、荆芥属多年生植物。入药用其干燥茎叶和花穗。
防风：伞形科植物防风的根。
红曲：是以籼米为原料，采用现代生物工程技术分离出优质的红曲霉菌 (monascuspurpureus)经液体深层发酵精制而成，是一种纯天然、安全性高、有益于人体健康的食品添加剂
三棱：为黑三棱科植物黑三棱Sparganium stoloni erum,Buch.–Ham.的干燥块茎。
莪术；为姜科植物蓬莪术Curcuma phaeocaulis Val.、广西莪术Curcuma Kwangsiensis S.G.Lee et C.F.Liang或温郁金Curcuma wenyujin Y.H.Chen et C.Ling的干燥根茎
泽泻：Alisma plantago-aquatica Linn.多年生水生或沼生草本。
泽兰：是唇形科植物地瓜儿苗或毛叶地瓜儿苗的干燥地上部。
郁金：为姜科植物温郁金Curcuma rcenyujin Y，H.Chenet C.Ling、姜黄Curcuma longaL.、广西莪术Curcumakwangsiensis S.G.Lee et C.F.Liang或蓬莪术Curcuma pha eocaulis Val.的干燥块根。
巴戟天：学名：Morinda officinalis How，为双子叶植物茜草科巴戟天的干燥根。
淫羊藿：学名：Epimedium brevicornu Maxim.多年生草本植物全草。
葛根：为豆科植物野葛的干燥根
藿香：属唇形目，唇形科多年生草本植物，又名：合香、苍告、山茴香全草。
佩兰：拉丁学名Eupatorium aponic Turcz.为菊科植物佩兰(兰草)，以全草入药。
沙参：拉丁学名：Adenophora stricta Miq.〕桔梗科沙参属多年生草本植物，根部入药。
麦冬：麦冬(学名：Ophiopogon aponicas(Linn.F.)Ker-Gawl.)百合科沿阶草属多年生常绿草本植物的块根。
柿蒂：为柿树科植物柿Diospyros kaki Thunb.的干燥宿萼
茯苓：为多孔菌科真菌茯苓Poria cocos(Schw.)Wolf的干燥菌核。
茯神：为白茯苓中心抱有细松根者。
辛夷：木兰花的花蕾。
苍耳子：属菊科、苍耳属一年生草本菊科植物苍耳的带总苞的果实。
旋复花：菊科旋复花，又名：金沸草、金钱花、滴滴金、盗瘐、夏菊、戴椹，干燥花朵入药。
代赭石：氧化物类矿物赤铁矿的矿石。
地榆：拉丁学名：Sanguisorba officinalis L.是蔷薇科地榆属多年生草本植物的根部。
槐角：豆科植物槐(Sophora japonica L.)的干燥花及花蕾、成熟果实。
延胡索；延胡索(Corydalis yanhusuo W.T.Wang ex Z.Y.Su et C.Y.Wu)，又名：延胡、玄胡索、元胡索、元胡等。是罂粟科、紫堇属多年生草本植物的块茎。
红花：红花，(拉丁学名：Carthamus tinctorius L.)，别名：红蓝花、刺红花，菊科、红花属植物，干燥的管状花入药。
土茯苓：为百合科植物光叶菝葜的干燥根茎
紫苑：学名：Aster tataricus L.f.，别名：青苑、紫倩、小辫等；菊科紫菀属，多年生草本的根状茎。
款冬：系菊科款冬属植物款冬(Tussilago farfara L.)的花蕾。
麻黄：麻黄科植物草麻黄、中麻黄或木贼麻黄的干燥草质茎
射干；为Belamcanda chinensis(L.)Redouté多年生草本的根状茎。
红参；是参的熟用品，其加工方法是经过浸润、清洗、分选、蒸制、晾晒、烘干等工序加工而成。
具体实施方式
以下通过具体实施方式说明本发明的中药组合物及其制品的制备方法和临床功效。
实施例1-89归一饮的配方及制备
表1实施例1-89的归一饮的配方
Figure PCTCN2017081380-appb-000001
Figure PCTCN2017081380-appb-000002
Figure PCTCN2017081380-appb-000003
Figure PCTCN2017081380-appb-000004
汤剂制备步骤如下：
(1)按表1所列的各配方准备原料药
(2)每剂药每次300-800毫升，文火，对制附子先煎煮至少30分钟；
(3)加入其余两种药材煎煮提取；
(4)再加水1-2次，合并煎煮液得口服归一饮汤剂。
注：本发明中提到一剂药时，以实施例1为例，其一剂药相当于是以“炙甘草20g、干姜15g、制附子10g”为原料药制备得到的口服制品。其余实施例以此类推。
本发明的配方中，干姜可用炮姜替代。
临床实验例：
记录实施例1-89的药物进行临床用药观察；
统计结果显示，实施例1-16的中药组合物对诸多病症具有显著的疗效，临床观察统计如下表2：
表2临床实验例观察统计
Figure PCTCN2017081380-appb-000005
Figure PCTCN2017081380-appb-000006
表2中1-16配方中各味药的重量份数值范围之间各个数值点在门诊治疗的处方中都有使用，例如炙甘草2-6重量份，表示2重量份，2.1重量份，2.2重量份，2.3重量份，2.4重量份，2.5重量份，2.6重量份，2.7重量份…5.5重量份，5.6重量份，5.7重量份,5.8重量份,5.9重量份，6重量份都使用过；
干姜1-1.5重量份表示1重量份、1.1重量份，1.2重量份，1.3重量份，1.4重量份1.5重量份都开过处方；
其余原料的数值范围也如此，在若干门诊治疗过程中，根据症状的程度不同，采用过该范围内的不同数值。
在发明人的进一步实践中，发现在实施例1-16的多功效中药组合物基础上，针对具体不同的症状选择性添加不同的辅助性原料药，药效更为显著和具有针对性，部分临床观察病例治愈统计如下表3：
表3归一饮衍生配方临床疗效统计
Figure PCTCN2017081380-appb-000007
Figure PCTCN2017081380-appb-000008
Figure PCTCN2017081380-appb-000009
Figure PCTCN2017081380-appb-000010
综上，本发明提供的多功效中药组合物本身，脱胎于四逆汤，但适应症比四逆汤更广泛， 药效温和安全，是属于除了严重阴虚的患者以及单纯实热证患者之外所有人都可以服用的具有保健功效的中药组合物；另一方面，在该多功效中药组合物基础上，添加适量的对应症状的原料药，可以得到疗效显著的针对不同病症的针对性药物组方。

Claims (10)

  1. 一种对多种症状具有功效的中药组合物，其特征在于,由2-6重量份的原料药A，0-1.5重量份的原料药B和1重量份的原料药C组成；
    所述原料药A为炙甘草、生甘草、大枣和/或薏米；
    所述原料药B为干姜或炮姜；
    所述原料药C为制附子；
    所述多种症状包括冠心病、高脂血症、心律失常、心力衰竭、高血压病、Ⅱ型糖尿病、心脏神经官能症、皮肤病、月经病、疼痛性疾病、便秘、失眠、颈椎、腰椎病、感冒、慢性支气管炎、人乳头瘤病毒感染、甲亢、神经性震颤、遗精、阳痿、小儿多动症、抑郁症、更年期综合征、慢性结肠炎、慢性胃炎、反流性食道炎、肿瘤康复、周围神经病、慢性泌尿性感染、过敏性疾病、带状疱疹、脑血管病、血液病。
  2. 根据权利要求1所述的中药组合物，其特征在于，由2重量份的原料药A，1-1.5重量份的原料药B和1重量份的原料药C。
  3. 根据权利要求1所述的中药组合物，其特征在于，由3-6重量份的原料药A，1-1.5重量份的原料药B和1重量份的原料药C。
  4. 一种中药组合物，是在权利要求1-3任一所述的中药组合物中添加以下任一组辅助原料药而得：
    荆芥和防风；
    红曲；
    三棱和莪术；
    泽泻和泽兰；
    郁金；
    巴戟天；
    枸杞子和淫羊藿；
    巴戟天和淫羊藿；
    葛根；
    藿香和佩兰；
    沙参和麦冬；
    黄芪；
    白术；
    茯神；
    半夏；
    肉苁蓉；
    杜仲和牛膝；
    丁香和柿蒂；
    茯苓和泽泻；
    辛夷和苍耳子；
    旋复花和代赭石；
    天麻；
    地榆和槐角；
    延胡索；
    红花和益母草；
    土茯苓；
    紫苑和款冬；
    麻黄和杏仁；
    半夏和桔梗；
    射干和麻黄；
    当归；
    丹参和红花；
    麦冬和五味子；
    红参；
    郁金和合欢花；
    合欢花；
    黄芪、女贞子和补骨脂；
    蜜麻黄或生麻黄；
    阿胶；
    当归；白芍；
    片姜黄；
    细辛；
    肉桂；
    伸筋草；
    巴戟天；
    山茱萸；
    熟地黄；
    生地黄；
    穿山甲；
    龟板；
    鳖甲；
    党参；
    人参；
    三七；
    木香；
    威灵仙；
    水蛭；
    全蝎；
    蜈蚣；
    合欢皮；
    酸枣仁；
    枳实；
    绞股蓝；
    黄杨宁；
    紫苑；
    鹿角胶；
    龟板胶；
    桃仁；
    地龙；
    枳椇子；
    菟丝子；
    锁阳；
    分心木。
  5. 根据权利要求4所述的中药组合物，其特征在于，其中，所述辅助原料药的重量份为：
    荆芥0.6-1.5重量份和防风0.6-1.5重量份；
    红曲0.6-1.5重量份；
    三棱0.6-1.5重量份和莪术0.6-1.5重量份；
    泽泻0.6-1.5重量份和泽兰0.6-1.5重量份；
    郁金0.6-1.5重量份；
    巴戟天0.6-1.5重量份；
    枸杞子0.6-1.5重量份和淫羊藿0.6-1.5重量份；
    巴戟天0.6-1.5重量份和淫羊藿0.6-1.5重量份；
    葛根0.8-1.2重量份；
    藿香0.6-1.5重量份和佩兰0.6-1.5重量份；
    沙参0.6-1.5量重量份和麦冬0.6-1.5重量份；
    黄芪0.6-1.5重量份；
    白术0.6-1.5重量份；
    茯神0.6-1.5重量份；
    半夏0.6-1.5重量份；
    肉苁蓉0.6-1.5重量份；
    杜仲0.6-1.5重量份和牛膝0.6-1.5重量份；
    丁香0.6-1.0重量份和柿蒂0.6-1.0重量份；
    茯苓0.6-1.5重量份和泽泻0.6-1.5重量份；
    辛夷0.6-1.0重量份和苍耳子0.6-1.0重量份；
    旋复花0.6-1.5重量份和代赭石重0.6-3量重量份；
    天麻0.6-2重量份；
    地榆0.6-1.5重量份和槐角0.6-1.5重量份；
    元胡0.6-1.5重量份；
    红花0.6-1.5重量份和益母草0.6-1.5重量份；
    土茯苓0.6-1.5重量份；
    紫苑0.6-1.5重量份和款冬0.6-1.5重量份；
    麻黄0.6-1.0重量份和杏仁0.6-1.5重量份；
    半夏0.6-1.5重量份和桔梗0.6-1.5重量份；
    射干0.6-1.5重量份和麻黄0.6-1.0重量份；
    当归0.6-1.5重量份；
    丹参0.6-1.5重量份和红花0.6-1.5重量份；
    麦冬0.6-1.5重量份和五味子重0.6-1.5量重量份；
    红参0.6-1.5重量份；
    郁金0.6-1.5重量份和合欢花0.6-1.5重量份；
    合欢花0.6-1.5重量份；
    黄芪0.6-1.5重量份、女贞子0.6-1.5重量份、补骨脂0.6-1.5重量份；
    蜜麻黄或生麻黄0.6-1.5重量份；
    阿胶0.6-1.5重量份；
    当归0.6-1.5重量份；白芍0.6-1.5重量份；
    片姜黄0.6-1.5重量份；
    细辛0.3-0.6重量份；
    肉桂0.6-1.5重量份；
    伸筋草0.6-1.5重量份；
    巴戟天0.6-1.5重量份；
    山茱萸0.6-1.5重量份；
    熟地黄0.6-1.5重量份；
    生地黄0.6-1.5重量份；
    穿山甲0.6-1.5重量份；
    龟板0.6-1.5重量份；
    鳖甲0.6-1.5重量份；
    党参0.6-1.5重量份；
    人参0.6-1.5重量份；
    三七0.6-1.5重量份；
    木香0.6-1.5重量份；
    威灵仙0.6-1.5重量份；
    水蛭0.6-1.5重量份；
    全蝎0.6-1.5重量份；
    蜈蚣0.6-1.5重量份；
    合欢皮0.6-1.5重量份；
    酸枣仁0.6-1.5重量份；
    枳实0.6-1.5重量份；
    绞股蓝0.6-1.5重量份；
    黄杨宁0.6-1.5重量份；
    紫苑0.6-1.5重量份；
    鹿角胶0.6-1.5重量份；
    龟板胶0.6-1.5重量份；
    桃仁0.6-1.5重量份；
    地龙0.6-1.5重量份；
    枳椇子0.6-1.5重量份；
    菟丝子0.6-1.5重量份；
    锁阳0.6-1.5重量份；
    分心木0.6-1.5重量份。
  6. 一种对多种症状具有功效的中药制品，其特征在于，由权利要求1-3任一所述的对多种症状具有功效的中药组合物或权利要求4或5所述的中药组合物为原料制成；
    所述多种症状包括冠心病、高脂血症、心律失常、心力衰竭、高血压病、Ⅱ型糖尿病、心脏神经官能症、皮肤病、月经病、疼痛性疾病、便秘、失眠、颈椎、腰椎病、感冒、慢性支气管炎、人乳头瘤病毒感染、甲亢、神经性震颤、遗精、阳痿、小儿多动症、抑郁症、更年期综合征、慢性结肠炎、慢性胃炎、反流性食道炎、肿瘤康复、周围神经病、慢性泌尿性感染、过敏性疾病、带状疱疹、脑血管病、血液病。
  7. 根据权利要求6所述的中药制品，其特征在于，剂型为口服汤剂、散剂、颗粒剂、丸剂、片剂、胶囊、提取液、外用剂型。
  8. 根据权利要求6或7所述的中药制品，其特征在于，还包含用于制备所需剂型的药学上可接受的辅料。
  9. 权利要求6-8任一所述的中药制品的制备方法，其特征在于，包括对所述原料药进行煎煮制得中药水提取液。
  10. 根据权利要求9所述的制备方法，其特征在于，包括对所述制附子先煎煮至少15分钟，然后再加入其余原料药进行煎煮。
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