WO2017146141A1 - Agent de réhydratation - Google Patents

Agent de réhydratation Download PDF

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Publication number
WO2017146141A1
WO2017146141A1 PCT/JP2017/006803 JP2017006803W WO2017146141A1 WO 2017146141 A1 WO2017146141 A1 WO 2017146141A1 JP 2017006803 W JP2017006803 W JP 2017006803W WO 2017146141 A1 WO2017146141 A1 WO 2017146141A1
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WO
WIPO (PCT)
Prior art keywords
milk
hydration
present
agent
water
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PCT/JP2017/006803
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English (en)
Japanese (ja)
Inventor
伊藤　健太郎
Original Assignee
株式会社明治
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Publication date
Application filed by 株式会社明治 filed Critical 株式会社明治
Priority to CN201780011727.1A priority Critical patent/CN108697125A/zh
Priority to JP2018501755A priority patent/JP6961569B2/ja
Publication of WO2017146141A1 publication Critical patent/WO2017146141A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
    • A23L11/60—Drinks from legumes, e.g. lupine drinks
    • A23L11/65—Soy drinks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/66—Proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Definitions

  • the present invention relates to a hydration agent that contains milk protein, sodium, carbohydrates, and stabilizers as active ingredients and is acidic.
  • Dehydration and heat stroke are likely to occur not only during exercise and work in hot weather, but also in daily indoor activities such as sleep, in a hot and humid environment.
  • elderly people whose body fluids (the total amount of water in the body including water and electrolytes) are decreasing, and the amount of food important for water intake tends to decrease, and children who are susceptible to temperature (age 0-15) ), It is difficult to notice that dehydration is occurring, and gradually becoming dehydration, so-called heat stroke from hide dehydration is a serious problem.
  • Milk has excellent ability to retain ingested water, but casein, which is a component of milk, solidifies in the stomach, causing slower gastric emptying and slower water absorption into the body than water and sports drinks. There was a problem with.
  • Non-Patent Documents 1 and 2 sports drinks containing carbohydrates and electrolytes are often used for the purpose of replenishing carbohydrates consumed by exercise and electrolytes lost by sweating, and the effectiveness of hydration has been reported so far (for example, Non-Patent Documents 1 and 2).
  • these sports drinks are not necessarily sufficient from the viewpoint of maintaining moisture in the body for a long time, and are reported to be inferior to milk (for example, see Non-Patent Document 3).
  • Oral Rehydration Solution is a beverage developed to treat dehydration in cholera that causes diarrhea that loses a large amount of sodium. It is a beverage containing a lot of sodium and is often adjusted to be hypotonic (hypotonic solution) having a lower osmotic pressure than body fluid.
  • hypotonic hypotonic solution
  • oral rehydration designed for the treatment of pathological dehydration, such as vomiting and diarrhea can be used in hydration in healthy people's exercise, work, and daily activities. In the long term, it may induce hypertension.
  • Patent Document 1 discloses a plasma volume increase accelerator comprising a gel composition as an active ingredient, but the gel composition contains calcium and is completely different from the food and drink of the present invention. Is.
  • Patent Document 2 discloses an acidic protein composition containing a protein derived from an aqueous protein isolate. However, the composition is essentially free of caseinate, and thus the food / beverage product of the present invention. Are completely different.
  • An object of the present invention is to provide a hydration agent having a property of rapidly absorbing water into a living body.
  • the present inventors have found that when a mixture containing milk protein, sodium, carbohydrates, and stabilizers as active ingredients and made acidic is ingested with water, the water is immediately taken into the living body. A replenisher was developed. It was also unexpectedly found that this hydration agent is not excreted as urine even when the taken-in water elapses for a long time and can retain water in the body for a long time.
  • the present invention is based on these findings.
  • a hydration agent that contains milk protein, sodium, carbohydrates, and stabilizers as active ingredients and is acidic [2] The hydration agent according to (1), which is for hydration retention. [3] The hydration agent according to (1) or (2), wherein the milk protein concentration is 2 to 7% by weight. [4] The hydration agent according to any one of (1) to (3), wherein the sodium concentration is 0.005 to 0.1% by weight. [5] The hydration agent according to any one of (1) to (4), wherein the sugar concentration is 0.1 to 10% by weight.
  • the stabilizer is 0.2 to 1.2 mass% soybean polysaccharide, 0.1 to 0.5 mass% HM pectin, and 0.01 to 0.1 mass% fibrous insoluble cellulose.
  • Moisture comprising allowing a subject to ingest the hydration agent according to any one of (1) to (8) or the dairy food or drink for hydration according to (9) or (10) Supply method.
  • the present invention it is possible to provide a hydration replenishment agent having a property of rapidly absorbing water into the living body. Moreover, according to the preferable aspect of this invention, the water
  • FIG. 1 shows the plasma volume change rate (%) at each time point after oral administration of beverages.
  • FIG. 2 shows cumulative urine excretion (mL) at each time point after oral administration of beverages.
  • the hydration (use) agent of the present invention is a hydration agent that contains milk protein, sodium, carbohydrates, and stabilizers as active ingredients and is acidic. Since the hydration agent of the present invention has a property of rapidly absorbing water into the living body, dehydration and heat stroke can be quickly alleviated and prevented.
  • the hydration agent of the present invention includes not only those containing a predetermined amount of moisture described later, but also those containing an amount of moisture less than a predetermined amount of moisture and those from which a predetermined amount of moisture has been substantially removed. To do.
  • the amount required when ingesting or administering the one containing a water amount that is less than the predetermined amount of water or the one where the predetermined amount of water is substantially removed. Is taken or administered simultaneously or separately with the hydration agent.
  • the hydration agent of the present invention preferably contains a predetermined amount of water described below from the viewpoint of ingestion or administration convenience.
  • a hydration agent is prepared as a mixture containing a predetermined amount of water, as it simultaneously ingests or administers a predetermined amount of water. That is, according to a preferred embodiment of the present invention, there is provided a hydration agent which contains milk protein, sodium, carbohydrate, stabilizer and water as active ingredients and is acidic.
  • the “active ingredient” means a component required for providing a hydration effect and / or a moisture retention effect, and preferably supplies water to the body and / or retains moisture in the body. It means an ingredient required for providing a hydration effect and / or a moisture retention effect for a subject in a difficult environment and / or condition.
  • the “subject in an environment and / or state in which it is difficult to replenish and / or retain water in the body” means a subject in which bodily fluids, that is, water and / or electrolytes in the body are likely to decrease.
  • bodily fluids that is, water and / or electrolytes in the body are likely to decrease.
  • Examples thereof include subjects that perform continuous exercise such as strength training, outdoor work such as in hot weather, and indoor daily activities such as sleep, particularly daily activities in a hot and humid environment. Dehydration is likely to occur during continuous exercise, outdoor work, or daily activities in a hot and humid environment. Therefore, subjects who take the hydration agent of the present invention include dehydration and heat stroke reserves (such as those who have dehydration) and those suffering from dehydration and heat stroke.
  • the subject ingesting the hydration agent of the present invention is not particularly limited as long as it is a subject that needs to replenish and / or retain moisture in the body. Is a person who loses or is expected to lose water corresponding to 1 to 9% by weight of the weight of each subject.
  • the weight loss due to water loss such as sweating is 1-2% by weight, it is classified as mild dehydration, 3-9% by weight is moderate dehydration, and 10% by weight or more is classified as severe dehydration.
  • This object also includes animals other than humans (domestic animals such as horses and cows, pets such as dogs and cats, appreciation animals kept in zoos, etc.).
  • the water replenishing agent of the present invention can be replenished promptly when ingested by a subject that needs to replenish water in the body simultaneously or separately with a predetermined amount of water.
  • “soon” means that the amount of plasma in the body can be increased within 60 minutes, preferably within 30 minutes, more preferably within 15 minutes after ingesting water.
  • an immediate (rapid) (for example, within 60 minutes) replenishment agent is provided.
  • the hydration agent of the present invention can retain moisture in the body for a long time when ingested by a subject that needs to retain moisture in the body simultaneously or separately with a predetermined amount of moisture.
  • long time means a time during which a desired water retention effect can be obtained, although it varies depending on the environment and / or state in which it is difficult to retain moisture in the body.
  • long time means that during normal daily activities, preferably 2 hours after ingestion, more preferably 3 hours after ingestion, more preferably 4 hours after ingestion, more preferably after ingestion.
  • a hydration long-term retention agent for example, 2 hours or more
  • the hydration effect means that most of the water ingested simultaneously or separately with the hydration agent (or hydration retention agent) of the present invention can be present in plasma in the body.
  • the hydration action can be confirmed by, for example, a rat plasma comparison test. Specifically, in the time after intake of the test solution and distilled water, the same amount of distilled water as the test solution is distilled. If the amount of plasma is high when the test solution is ingested as compared to the case of ingesting water, it can be determined that it is significant (for example, see Test Example 1 below). More specifically, the hydration effect can be confirmed from the plasma volume change rate (%).
  • the water retention effect means that most of the water taken simultaneously or separately with the hydration agent of the present invention (or hydration retention agent) can be retained in the body for a long time without being discharged as urine. Means.
  • the water retention action can be confirmed by, for example, a comparative test of rat urinary excretion. Specifically, in the time after intake of the test liquid and distilled water, the same amount as the water of the test liquid. It can be determined that the amount of urinary excretion is small when the test solution is ingested compared to the case of ingesting distilled water (for example, see Test Example 2 below).
  • the water retention action can be confirmed from the water retention rate, and the water retention rate (%) can be determined from the formula 1: [1- (urine excretion / intake)] ⁇ 100. Can be calculated.
  • the plasma volume change rate (%) is, for example, 3% or more, preferably 5% or more, 15 minutes after ingestion. Preferably it is 7% or more, More preferably, it is 10% or more.
  • the moisture retention rate is 65%, preferably 70%, more preferably 2 hours after ingestion. Is 80%, more preferably 85%, more preferably 90%.
  • the hydration agent (or hydration retention agent) of the present invention can retain moisture in the body for a long time. That is, since the hydration agent of the present invention has an excellent water retention effect, it is not necessary to ingest it repeatedly within a short period of time if sufficient water can be ingested (administered) into the body. Therefore, the ingestion (administration) interval for ingesting (administering) the hydration agent of the present invention to a subject who needs to retain the moisture in the body, for example, from the first intake of the hydration agent of the present invention.
  • the interval from the next intake or the interval from the next intake to the next intake can be at least 0.5 hours.
  • the intake interval is preferably at least 1 hour, more preferably at least 2 hours, more preferably at least 3 hours, more preferably at least 4 hours, more preferably at least 5 hours, more preferably at least 6 hours, particularly preferably at least It can be 7 hours, most preferably at least 8 hours.
  • the number of times of intake (administration) of the hydration agent of the present invention to be ingested (administered) by a subject that needs to retain moisture in the body is not particularly limited, but sufficient water can be ingested (administered) in the body. That is, as long as it can be replenished, it may be taken once, that is, with a single breath (once).
  • the intake of water sufficient for the body varies as appropriate depending on the environment and / or condition in which it is difficult to retain water in the body, but in the case of humans, it is 50 to 1000 ml, preferably 100 to 1000 ml, more preferably 150 to 1000 ml. 1000 ml, more preferably 200 to 1000 ml, particularly preferably 250 to 1000 ml.
  • the method (or method of administration) for ingesting (or administering) the hydration agent of the present invention simultaneously with or separately from a predetermined amount of water includes oral administration (or oral administration), enteral administration, gastric fistula, etc. Although it can select suitably by a use, Preferably it is oral intake (or oral administration).
  • the hydration agent of the present invention can achieve prevention and alleviation of dehydration and thus prevention and alleviation of heat stroke by ingesting simultaneously or separately with a predetermined amount of water. That is, the hydration agent of the present invention can be used as a preventive (use) agent and / or a treatment (use) agent for dehydration or heat stroke.
  • the hydration agent of the present invention is preferably a hydration retention agent.
  • the hydration replenishment retention (use) agent of the present invention has characteristics that the water absorption into the living body is fast and the water is retained in the living body for a long time.
  • the hydration retention agent of the present invention has such characteristics, so that dehydration and heat stroke can be alleviated promptly and dehydration and heat stroke can be effectively prevented. This is advantageous in that
  • the hydration agent and the hydration retention agent of the present invention replenish or retain moisture on a hot day, etc. before, after exercising, before waking up, before going to bed, taking a bath, drinking alcohol, etc. This is particularly effective when
  • the hydration agent and hydration retention agent of the present invention are not only intended for exercise, but also for children who need hydration and retention, elderly people who need heat stroke measures, and manual workers. Useful.
  • “hydration” is based on the property of rapid water absorption into the living body, and other terms may be used as long as this means.
  • “Hydration supplement” is, for example, “moisture absorption promoting agent”, “moisture absorption improving agent”, “hydration quick replenishing agent”, “hydration replenishment improving agent”, “blood volume increase promoting agent”.
  • “hydration retention” is based on the property that moisture absorption into the living body is fast and the moisture is retained in the living body for a long time.
  • “Hydration replenishment retention agent” includes, for example, “moisture absorption retention promotion agent”, “moisture absorption retention improvement agent”, “hydration retention enhancement agent”, “blood volume increase promotion retention agent”, “moisture retention” It may be rephrased as “recovery promoting retention agent”, “plasma mass increase promoting retention agent” or the like.
  • the pH of the hydrating agent of the present invention is not particularly limited as long as it is acidic, but is preferably 3 to 6, more preferably 3 to 5, and further preferably 3.5 to 4. 5.
  • the milk protein contained in the hydrating agent of the present invention is not particularly limited as long as it is a milk-derived protein.
  • the milk protein contained in the hydration agent of the present invention is, for example, whey protein, casein protein, whey protein degradation product, casein protein degradation product, peptide, or non-protein nitrogen component at a specific concentration (content). What is included.
  • This “milk protein” is a mixture of whey protein, casein protein, whey protein degradation product, casein protein degradation product, peptide, or non-protein nitrogen component that has been separated and purified separately to a specific concentration.
  • milk protein used in the present invention does not require a separation step or purification step of whey protein, casein protein, whey protein degradation product, casein protein degradation product, peptide, or non-protein nitrogen component.
  • the main ingredients are whey protein, casein protein, whey protein degradation product, casein protein degradation product, or ingredients and foods and beverages that already contain peptides and non-protein nitrogen components at specific concentrations.
  • components if necessary, use separately purified whey protein, casein protein, whey protein degradation product, casein protein degradation product, or peptide and non-protein nitrogen components to a specific concentration Is preferred.
  • the milk protein contained in the hydration agent of the present invention one kind of milk may be used alone, or two or more kinds of milk may be mixed and used.
  • the milk protein may be a high-purity component such as a chemical (such as a reagent) or a mixed component such as a separated product or a purified product.
  • the protein content may be calculated on the basis of known information such as a food composition table, or may be calculated by measuring by a conventional method such as the Kjeldahl method or the Raleigh method. Actually, in the case of the Kjeldahl method, it can be calculated by measuring nitrogen contained in various proteins and multiplying the value by a nitrogen-protein conversion factor (usually 6.25).
  • the milk protein contained in the hydration agent of the present invention may contain casein, and the milk protein containing casein refers to a milk protein composed of casein protein and whey protein.
  • the ratio of the weight of casein protein and whey protein in the hydration agent of the present invention is, for example, 20: 1, 15: 1, 12: 1, 10 as (casein protein) :( whey protein).
  • the ratio of the weight of casein protein to whey protein in the hydration agent of the present invention is, for example, 20 to 1: 1 to 20, preferably 15 to 1: 1 as (casein protein) :( whey protein).
  • the ratio of the weight of casein protein to whey protein in the hydration agent of the present invention is, for example, 20 to 1: 1 to 20, preferably 15 to 1: 1 as (casein protein) :( whey protein).
  • the ratio of the weight of casein protein and whey protein in the milk protein contained in the hydration agent of the present invention is (casein protein) :( whey protein), for example, 5 to 3: 2 It may be ⁇ 0.5, preferably 4: 1.
  • the viscosity (10 ° C.) of the hydration agent of the present invention is, for example, 3 to 30 mPa ⁇ s, preferably 3.5 to 30 mPa ⁇ s, more preferably 4 to 30 mPa ⁇ s, and further preferably 4.5 to 30 mPa. S, more preferably 5 to 30 mPa ⁇ s, more preferably 5.5 to 29 mPa ⁇ s, more preferably 6 to 28 mPa ⁇ s, still more preferably 6.5 to 27 mPa ⁇ s, and even more preferably 7 to 26 mPa ⁇ s.
  • This viscosity is a viscosity measured with a B-type rotational viscometer, and can be measured using a general-purpose Brookfield viscometer.
  • the viscosity (10 ° C.) of the hydration agent of the present invention exceeds 3 mPa ⁇ s
  • the hydration agent of the present invention due to destabilization of the casein protein This is preferable in that separation and precipitation can be prevented.
  • the viscosity (10 ° C.) of the hydrating agent of the present invention is less than 30 mPa ⁇ s, so that even a hydrating agent containing milk protein containing a high concentration of casein has a low viscosity and is easy to drink. It is preferable because it can be prevented from disappearing.
  • the concentration of milk protein contained in the hydration agent of the present invention is not particularly limited as long as the effects of the present invention are exhibited, but is preferably 2 to 7% by weight, more preferably 3 to 5% by weight. is there.
  • the concentration of sodium contained in the hydrating agent of the present invention is not particularly limited as long as the effects of the present invention are exhibited, but is preferably 0.005 to 0.1% by weight, more preferably 0.01. It is ⁇ 0.05% by weight, more preferably 0.01 to 0.02% by weight.
  • the sodium concentration may be calculated based on known information such as a food composition table, or may be calculated by measurement by a conventional method.
  • Sodium contained in the hydration agent of the present invention may be a high-purity component such as a chemical (such as a reagent), or may be a raw material or food or drink containing sodium. Milk raw materials and dairy products containing sodium derived from milk may be used.
  • the sugar (carbohydrate) contained in the hydration agent of the present invention is not limited to its origin or form, and for example, lactose, sugar, fructose, glucose, maltose, trehalose, isomaltulose (as a commercial product, for example, , Palatinose (made by Mitsui Sugar Co., Ltd.)), oligosaccharide, dextrin, starch, and dietary fiber.
  • the carbohydrate is preferably lactose, sugar, glucose, maltose, trehalose, isomaltulose, or dextrin from the viewpoint of enhancing the moisture retention effect over a long period of time.
  • this carbohydrate may be used individually by 1 type, and 2 or more types may be mixed and used for it.
  • the sugar concentration may be calculated based on known information such as a food composition table, or may be calculated by measurement by a conventional method.
  • the saccharide used in the present invention may be a high-purity component such as a chemical (such as a reagent), or may be a raw material or food or drink containing the saccharide, for example, derived from milk. Milk raw materials and dairy products that contain sugars (the main component is lactose) may be used.
  • a food additive known as a saccharide may be used at a desired concentration.
  • Carbohydrates contained in the hydration agent of the present invention are not particularly limited as long as the effects of the present invention are exhibited, and examples thereof include trehalose, sucrose, isomaltulose, maltose, lactose, glucose, and dextrin.
  • trehalose sucrose, isomaltulose, maltose, lactose, glucose, and dextrin.
  • Trehalose is also commercially available. For example, Treha (manufactured by Hayashibara) can be used.
  • the concentration of the saccharide contained in the hydration agent of the present invention is not particularly limited as long as the effects of the present invention are exhibited, but is preferably 0.1 to 10% by weight, more preferably 1 to 6% by weight. %, More preferably 2 to 3% by weight.
  • the stabilizer contained in the hydration agent of the present invention is not particularly limited as long as the effects of the present invention are exhibited, preferably soybean polysaccharides, HM pectin, or fibrous insoluble cellulose, More preferably 0.2 to 1.2% by weight soybean polysaccharide, 0.1 to 0.5% by weight HM pectin, and 0.01 to 0.1% by weight fibrous insoluble cellulose It is.
  • milk protein, sodium, carbohydrates, 0.2-1.2 wt% soy polysaccharide, 0.1-0.5 wt% HM pectin, and 0.01- It is a hydrating agent that contains 0.1% by weight of fibrous insoluble cellulose as an active ingredient and is acidic.
  • the soybean polysaccharide may be any one that contains one or more of rhamnose, galactose, arabinose, xylose, glucose, and uronic acid derived from soybean, and among soybeans, those derived from cotyledons are preferable.
  • the molecular weight of the soybean polysaccharide of the present invention is not particularly limited, but is preferably a high molecular weight, and has an average molecular weight of several thousand to several million, specifically 5,000 to 1,000,000. preferable.
  • the average molecular weight of the soybean polysaccharide is a value determined by an intrinsic viscosity method in which the viscosity in a 0.1 M NaNO 3 solution is measured using standard pullulan (Showa Denko KK) as a standard substance.
  • Such soybean polysaccharides are commercially available, and for example, SM-700 (manufactured by Saneigen FFI) or SM-900 (manufactured by Saneigen FFI) can be used. Soy polysaccharides are said to suppress separation and precipitation of food and drink caused by acid coagulation between casein proteins in the food and drink due to the structure of their side chains.
  • the concentration of soybean polysaccharide contained in the hydration agent of the present invention is, for example, 0.1 to 0.5% by weight of HM pectin, 0.01 to 0.1% by weight of the hydration agent of the present invention.
  • fibrous insoluble cellulose for example, 0.2 to 1.2% by weight, preferably 0.25 to 1.15% by weight, more preferably 0.3 to 1.1% by weight, Preferably 0.35 to 1.05% by weight, more preferably 0.4 to 1% by weight, more preferably 0.4 to 0.9% by weight, and still more preferably 0.4 to 0.6% by weight. .
  • the concentration of the soybean polysaccharide contained in the hydration agent of the present invention is preferably less than 1.2% by weight in order to avoid the hydration agent from feeling a unique flavor of soybeans. Further, when the concentration of soybean polysaccharide contained in the hydrating agent of the present invention exceeds 0.2% by weight, the occurrence of separation and precipitation of the hydrating agent of the present invention is suppressed, and further, redispersion It is preferable for improving the property.
  • HM pectin is an acidic polysaccharide having ⁇ -D-galacturonic acid as a main chain component, which exists as a cell wall component in vegetables and fruits.
  • Galacturonic acid constituting pectin is partially methyl esterified and is divided into LM pectin and HM pectin depending on the degree of esterification.
  • HM pectin generally has a degree of esterification of 50% or more.
  • Such HM pectin is commercially available, for example, SM-478 (manufactured by Saneigen FFI, Inc.), SM-666 (manufactured by Saneigen FFI, Inc.), AYD5110SB (manufactured by Unitech Foods, Inc.). )and so on.
  • HM pectin is characterized by being negatively charged, and it is said that by binding to casein protein, the bound casein proteins repel each other due to charge, thereby preventing aggregation of casein proteins.
  • the concentration of HM pectin contained in the hydrating agent of the present invention is 0.2 to 1.2% by weight of soybean polysaccharide and 0.01 to 0.1% by weight of fibrous material in the hydrating agent of the present invention.
  • insoluble cellulose for example, 0.1 to 0.5% by weight, preferably 0.1 to 0.45% by weight, more preferably 0.1 to 0.4% by weight, still more preferably 0.1 to 0.35 wt%, more preferably 0.1 to 0.3 wt%, more preferably 0.12 to 0.29 wt%, more preferably 0.14 to 0.28 wt%, It is preferably 0.16 to 0.27% by weight, more preferably 0.18 to 0.26% by weight, and still more preferably 0.2 to 0.25% by weight.
  • HM pectin contained in the hydration agent of the present invention is less than 0.5% by weight, so that it is a hydration agent containing milk protein containing a high concentration of casein, but is low in viscosity and easy to drink This is preferable. Further, when the concentration of HM pectin contained in the hydrating agent of the present invention exceeds 0.1% by weight, separation of the hydrating agent and occurrence of precipitation are suppressed, and redispersibility is also good. This is preferable.
  • Fibrous insoluble cellulose is one that can be incorporated into a hydration agent to build a three-dimensional network structure in the food and drink, and can improve the dispersibility of insoluble components such as precipitates. it can.
  • the fibrous insoluble cellulose suppresses separation and precipitation of the hydration agent, has good redispersibility, and has a low viscosity and is easy to drink, so there is no limitation on its origin, plant origin and / or Those derived from microorganisms can be used.
  • the fibrous insoluble cellulose derived from a microorganism is, for example, one obtained by separating a fermented cellulose produced by a microorganism from a culture medium, washing it, and appropriately purifying it into a fibrous form.
  • the fibrous insoluble cellulose is, for example, a fibrous insoluble cellulose microfibrillated to an average diameter of 0.01 to 0.1 ⁇ m (see, for example, JP-A-2005-245217) or fermented cellulose.
  • the fibrous insoluble cellulose of the present invention is commercially available.
  • Sun Artist PG manufactured by Saneigen FFI
  • Sun Artist PN manufactured by Saneigen FFI
  • the concentration of fibrous insoluble cellulose contained in the hydrating agent of the present invention is 0.2 to 1.2% by weight of soybean polysaccharide, 0.1 to 0.5% by weight of the hydrating agent of the present invention.
  • HM pectin is contained, for example, 0.01 to 0.1% by weight, preferably 0.015 to 0.09% by weight, more preferably 0.02 to 0.08% by weight, still more preferably 0.025 to 0.085 wt%, more preferably 0.03 to 0.07 wt%, more preferably 0.03 to 0.065 wt%, more preferably 0.03 to 0.06 wt%, Preferably it is 0.03-0.055 weight%, More preferably, it is 0.03-0.05 weight%.
  • the concentration of the fibrous insoluble cellulose contained in the hydration agent of the present invention is less than 0.1% by weight, the food or drink containing milk protein containing high concentration of casein is not in a form that is easy to drink with low viscosity. It is preferable to avoid this. Further, when the concentration of the fibrous insoluble cellulose contained in the hydrating agent of the present invention exceeds 0.01% by weight, separation of the hydrating agent and occurrence of precipitation cannot be suppressed, and further, redispersion It is preferable for avoiding that the property is not good.
  • the hydration agent of the present invention may contain a lipid.
  • the origin and form of these lipids are not limited, and as raw materials, for example, raw milk, whole fat concentrated milk, whole milk powder, (raw) cream, butter, vegetable oil, fish oil, lard, head, medium chain triacyl Glycerol oil is mentioned.
  • this "lipid” is preferably raw milk, full-fat concentrated milk, full-fat powdered milk, (raw) cream, butter as a raw material in that the sweetness and richness derived from lipids are good. That is, milk fat is preferable.
  • 1 type of this "lipid” may be used independently, and 2 or more types may be mixed and used for it.
  • the lipid content may be calculated, for example, based on known information such as a food composition table, or may be calculated by measuring by a conventional method.
  • a raw material or a food or drink containing a lipid may be used.
  • a milk raw material or a dairy product containing a lipid derived from milk may be used.
  • a known food additive may be used at a desired concentration.
  • the lipid content is preferably 3.9% by weight or less per hydrating agent when adjusted as a mixture containing a predetermined amount of moisture.
  • the hydration agent of the present invention exerts its hydration effect and / or moisture retention effect even if it does not contain lipid.
  • it if it contains lipid, it has a rich feeling derived from lipid. It is preferable at the point which can provide. Therefore, according to a preferred embodiment of the present invention, in the hydrating agent of the present invention, when the lipid content is adjusted as a mixture containing a predetermined amount of water, preferably 0.3 to 3.9 per hydrating agent. % By weight, more preferably 0.5 to 3.5% by weight, still more preferably 0.8 to 3.0% by weight, particularly preferably 1.0 to 2.5% by weight, most preferably 1.2 to 2%. 0.0% by weight.
  • the hydration agent of the present invention even if the hydration agent of the present invention does not contain lipid, in order to exert its effect, it is necessary to limit the intake of lipid, for example, lifestyle Efficient water retention can be achieved for subjects suffering from diseases or lipid metabolism disorders.
  • the hydration agent of the present invention preferably contains no lipid, but when using a milk raw material or a dairy product as the raw material, it is difficult to completely remove the lipid, When prepared as a mixture containing a predetermined amount of water, the hydration agent of the present invention comprises at least about 0.05% by weight of lipid per hydration agent.
  • the lipid content of the hydrating agent of the present invention is preferably adjusted to 0.000 per hydrating agent when adjusted as a mixture containing a predetermined amount of moisture.
  • the hydration agent of the present invention may contain water, and the water here may be water in the body and is taken at the same time or separately from the hydration agent of the present invention. Meaning, for example, tap water, mineral water, well water, distilled water, pure water, and carbonated water.
  • the hydrating agent of the present invention is prepared as a mixture containing a predetermined amount of water, the predetermined amount of water is desirably 75.1 to 99.35% by weight per hydrating agent.
  • the hydration agent of the present invention may be in a form containing a predetermined amount of water or a form (liquid form) as a mixture containing an amount of water less than the predetermined amount of water as long as the effect is exhibited.
  • a form from which a predetermined amount of moisture has been substantially removed (dried form), for example, solid (powder, granule, capsule, block, etc.), liquid, gel, paste, It can take the form of a paste.
  • moisture when it is in a solid state, moisture can be separated, so that the storage stability and portability can be improved. As a result, it can be said that the preservability is high.
  • the hydration agent of the present invention is desirably ingested at a rate of 0.07 g / kg body weight per meal, preferably 0.1 to 4.4 g / kg. More preferably 0.2 to 2.7 g / kg, still more preferably 0.2 to 1.8 g / kg, particularly preferably 0.2 to 0.9 g / kg.
  • the representative weight of the subject is estimated to be 60 kg.
  • the water content can be adjusted as appropriate so that the amount of ingested meal is, for example, 200 to 1000 ml, preferably 400 to 1000 ml when prepared as a mixture containing water. it can.
  • the hydration agent of the present invention comprises a unit package form per serving, and the milk package, sodium, carbohydrate, and stabilizer are contained in the unit package form.
  • the meal intake is adjusted to, for example, 1 to 26 g, preferably adjusted to 4 to 26 g, and in another aspect, preferably 2 to 16 g, more preferably 2 to 13 g, and still more preferably Is adjusted to 2 to 11 g.
  • ⁇ consisting of a unit packaging form per meal '' is a form in which the intake amount per meal is determined in advance, for example, as a food and drink that can be taken orally in a specific amount, not only general foods, It means forms such as beverages (drinks, etc.), health supplements, health functional foods, and supplements.
  • unit packaging form per meal for example, in the case of liquid beverages, gel-like, paste-like, or paste-like jelly, powder-like, granule-like, capsule-like, or block-like solid foods, etc.
  • Dose can be specified on a packaging container or a homepage, and the specific amount can be specified.
  • the water content can be adjusted as appropriate so that the amount of ingested meal is, for example, 200 to 1000 ml, preferably 400 to 1000 ml when prepared as a mixture containing water. it can.
  • the form when the form is a so-called health drink, 4 to 26 g of “milk protein, sodium, carbohydrate, and stabilizer” Adjust the water content so that the beverage in which the water is suspended or dissolved is 200 to 1000 ml per serving (dose), for example, metal cans, glass bottles (bottles, etc.), plastic containers (pet bottles, etc.) ) In a packaging container (filled).
  • a beverage in which 4 to 26 g of “milk protein, sodium, carbohydrates, and stabilizer” are suspended or dissolved is used as a package container, homepage, etc.
  • the capacity of several meals is put in a large capacity packaging container.
  • the hydration agent of the present invention is produced so as to contain a predetermined component
  • its production process is not limited.
  • it is a production process of milk, component-adjusted milk, processed milk, milk beverage, etc.
  • the hydration agent of the present invention includes, for example, various components such as milk protein and milk fat with respect to raw milk (raw milk), sterilized milk, concentrated milk, powdered milk, and reduced milk according to a known manufacturing method (manufacturing method).
  • It can be manufactured by blending (adjusting) the ingredients, or various ingredients such as milk protein and milk fat can be blended (adjusted) with component-adjusted milk and processed milk (such as low-fat milk and non-fat milk). ) Can also be manufactured.
  • the hydration agent of the present invention has high heat resistance (thermal stability) and exhibits a heat resistance effect.
  • having a heat-resistant effect means that the protein does not solidify (aggregate) due to heat denaturation even when it is treated at a specific temperature. Specifically, it is a condition used in general processing of milk. This means that the protein is not heat denatured even if heat-sterilized by the method.
  • the heat replenishment agent of the present invention is more specifically heat sterilized (LTLT treatment: low temperature and long time heating) at 62 to 65 ° C. for 30 minutes, or As a method having a sterilizing effect of the same degree or more, for example, heat sterilization (UHT treatment: ultra-high temperature heating) at 120 to 150 ° C.
  • the heat sterilization method includes a batch type in which the processing liquid is heated and held using a tank or the like, an indirect heating type using a plate type heat exchanger or a tube type heat exchanger, and a steam injection type heating device. And a known method such as a direct heating method using a steam infusion type heating device or a current heating method using a Joule heating device can be used.
  • the hydration agent of the present invention has a heat resistance effect. Therefore, in a composition in which the hydrating agent of the present invention is blended (added, mixed), the hydrating agent of the present invention has a heat-resistant effect, and thus can be preferably provided as a liquid product form. It can be provided as a product form for warm sales using a hot vendor or the like.
  • the form of the composition containing the hydration agent of the present invention is a form as a mixture containing a predetermined amount of water of the hydration agent of the present invention, as long as the effect is exhibited, Alternatively, it may be in a form (liquid form) as a mixture containing an amount of water less than a predetermined amount of water, or in a form (dried form) from which a predetermined amount of water has been substantially removed. It can be in the form of a solid (powder, granule, capsule, block, etc.), liquid, gel, paste or paste.
  • the composition of the present invention is ingested. Or, when administered, it is desirable to consume or administer the required amount of water simultaneously or separately with the composition.
  • a hydration dairy food or drink that contains milk protein, sodium, carbohydrates, and stabilizers as active ingredients and is acidic.
  • the hydrating milk food or drink of the present invention may be a hydrating food or drink composition.
  • the dairy food or drink for hydration is a dairy food or drink for hydration retention.
  • the food / beverage products of the present invention take the form of solid (powder, granule, capsule, block, etc.), liquid, gel, paste, paste, etc., similar to the hydration agent of the present invention. be able to.
  • Hydration dairy foods and drinks display effects based on the characteristics of fast water absorption into the living body or effects based on the characteristics of fast water absorption into the living body and long-term moisture retention in the living body. Products.
  • the food and drink of the present invention refers to food and drink containing milk and / or dairy products.
  • the milk is, for example, milk derived from mammals such as cow milk, sheep milk, goat milk, buffalo milk, sheep sheep milk, camel milk, whale milk, dolphin milk, human milk, and the like.
  • dairy products are processed milk and are known liquid ingredients such as skim milk, partially skim milk, desalted skim milk, desalted milk, ingredient-adjusted milk, whey, concentrated milk.
  • Non-fat concentrated milk, partially defatted concentrated milk, desalted and defatted concentrated milk, milk, cream permeate derived from dairy ingredients prepared by a known method, milk protein concentrate prepared by a known method, etc.
  • Raw materials such as powdered milk, butter, concentrated milk, milk, lactose, and whey minerals can also be used.
  • the food and drink of the present invention include health foods, functional foods, nutritional supplements, foods for specified health use, foods for the sick, infant formula, powdered milk for pregnant women and lactating women, or continuous Such foods are classified as foods and drinks with indications indicating that they are used for water retention.
  • the milk food or drink of the present invention is preferably a milk drink.
  • the pH, milk protein, milk protein concentration, sodium concentration, stabilizer and the like of the milk food and beverage product of the present invention may be the same as the hydration agent of the present invention.
  • the manufacturing method of the food / beverage products of this invention it may be the same as the hydration agent of this invention.
  • the hydration agent of the present invention may be a “pharmaceutical product” (pharmaceutical composition). That is, according to another aspect of the present invention, a hydration (or hydration retention) pharmaceutical product (pharmaceutical composition) containing milk protein, sodium, carbohydrate, and stabilizer as active ingredients and acidic. Product) is provided.
  • the “medicament” (pharmaceutical composition) is prepared as an oral preparation or a parenteral preparation according to a conventional method using additives that are acceptable for formulation.
  • the pharmaceutical is an oral preparation, it should be in the form of a solid preparation such as a tablet, powder, fine granule, granule, capsule, pill or sustained release, or a liquid preparation such as a solution, suspension or emulsion.
  • an oral preparation is preferable for a pharmaceutical product.
  • additives that are acceptable for formulation include, for example, excipients, stabilizers, preservatives, wetting agents, emulsifiers, lubricants, sweeteners, coloring agents, fragrances, buffers, antioxidants. Agents, pH adjusters and the like.
  • the pharmaceutical product (pharmaceutical composition) of the present invention can be applied to any disease as long as it is a disease that requires replenishment or retention of water, for example, treatment of dehydration or heat stroke or Can be used for prevention.
  • the pharmaceutical product (pharmaceutical composition) of the present invention is used for the treatment or prevention of diseases caused by water shortage in the body, such as constipation, hypertension, arteriosclerosis, thrombosis, cerebral infarction, myocardial infarction, gout, cancer and the like. You can also.
  • a food or drink used for replenishing water or a pharmaceutical product comprising milk protein, sodium, carbohydrate, and stabilizer as active ingredients, and being acidic Or the use of a medicinal product is provided.
  • a food or drink or a medicine for replenishing and retaining moisture comprising milk protein, sodium, carbohydrates and stabilizers as active ingredients.
  • a medicine for replenishing and retaining moisture comprising milk protein, sodium, carbohydrates and stabilizers as active ingredients.
  • food and drink or pharmaceuticals that are acidic.
  • a food or drink or a medicine for replenishing and / or holding water to a subject in an environment and / or in a state where it is difficult to rehydrate and / or retain water in the body
  • foods and beverages or pharmaceuticals that contain milk protein, sodium, carbohydrates, and stabilizers as active ingredients and are acidic is provided.
  • the use for the production of a food or drink or a medicine for replenishing water comprising milk protein, sodium, saccharide and stabilizer as active ingredients, and acidic Use for the manufacture of food or beverage or pharmaceutical products is provided.
  • Use is provided for the production of food or drink or pharmaceuticals which are contained as ingredients and are acidic.
  • milk protein, sodium, carbohydrate for supplying and / or holding water to a subject in an environment and / or condition in which it is difficult to supply and / or hold water into the body , And a stabilizer as an active ingredient and use for the production of foods and beverages or pharmaceuticals that are acidic.
  • an acidic food or drink or medicine containing milk protein, sodium, carbohydrate, and stabilizer as active ingredients and replenishing water.
  • a food or beverage or a medicine that contains milk protein, sodium, carbohydrates, and stabilizers as active ingredients and is acidic for replenishing and retaining moisture.
  • a food / beverage product or pharmaceutical that contains milk protein, sodium, carbohydrate, and stabilizer as active ingredients and is acidic for replenishing water.
  • an acidic food or drink or medicine containing as an active ingredient milk protein, sodium, carbohydrate, and stabilizer for replenishing and retaining moisture. Is done.
  • a hydration method comprising ingesting the hydration agent of the present invention or the hydrated milk food or drink of the present invention.
  • the subject may be a subject in an environment and / or condition that is difficult to rehydrate and / or retain water in the body.
  • a hydration method comprising subjecting the hydrating agent or hydrating milk food or drink of the present invention to a subject.
  • the “medical action for humans” means an action that requires a doctor or the like to ingest (administer) a medicine to a human.
  • the moisture retention method of the present invention can be carried out according to the contents described in the present specification for the moisture retention agent of the present invention.
  • the hydrating agent of the present invention is preferably a subject in an environment and / or condition in which it is difficult to replenish and / or retain water in the body, optionally simultaneously or separately with water, preferably Provided is a method for preventing and / or treating dehydration or heat stroke comprising ingesting an elderly person or a child.
  • the method for preventing and / or treating dehydration or heat stroke is a method for excluding medical practice for humans. The method for preventing and / or treating dehydration or heat stroke of the present invention can be carried out according to the contents described in the present specification for the water retention method of the present invention.
  • a food or drink for treatment or prevention of dehydration or heat stroke which contains milk protein, sodium, carbohydrates, and stabilizers as active ingredients and is acidic.
  • Product or a pharmaceutical product (pharmaceutical composition).
  • JIS Japanese Industrial Standard
  • the base mix was homogenized at 15 MPa (70 to 80 ° C.) with a plate sterilizer, sterilized at 130 ° C. for 2 seconds, and then cooled to 10 ° C. or lower to obtain the milk beverage (milk)
  • the protein was 3.5% by weight, soybean polysaccharide 0.45% by weight, HM pectin 0.2% by weight, fermented cellulose 0.05% by weight, trehalose 1% by weight) and used in Test Examples 1 and 2 below.
  • the milk beverage of the present invention had a pH of 4.1 and a viscosity of 10 mPa ⁇ s (10 ° C.). “Drinking mouth”, “precipitation” and “redispersibility” were all good.
  • the composition of the administered sports drink, milk, and milk drink of the present invention is shown in Table 1 below. Eight animals were used in each group.
  • results of rate of change in plasma volume The rate of change in plasma volume after oral administration of each beverage is shown in FIG.
  • the milk drink and sports drink of the present invention showed a significantly high plasma volume after 15 minutes compared to milk. It has been found that the milk beverage of the present invention has a faster water uptake into the body than milk. Moreover, the plasma volume change rate of the milk beverage of the present invention was higher than that of the sports drink at any time point after 15 minutes, 30 minutes, 60 minutes, 120 minutes, and 180 minutes.
  • Test Example 2 Nine-week-old male SD rats (manufactured by CLEA Japan, Inc.) were purchased and acclimated for one week. Rats were fasted for 20 hours and watered for 4 hours. Distilled water, sports drink (Pocari Sweat: manufactured by Otsuka Pharmaceutical Co., Ltd.), milk (Meiji Milk: manufactured by Meiji Co., Ltd.), or the milk beverage of the present invention prepared in Test Example 1 above was orally administered at 20 mL / kg, The sample was transferred to a urine collection cage, and urine excretion was measured until 4 hours later. Seven animals were used in each group.
  • FIG. 2 shows the cumulative urinary excretion after each beverage administration.
  • the milk beverage of the present invention showed a significantly lower value than that of the sports drink after 90 minutes (p ⁇ 0.05) (the statistical method was performed using the Tukey-kramer test. The same applies hereinafter. ).
  • the milk beverage of the present invention showed a significantly lower value than distilled water after 60 to 240 minutes (p ⁇ 0.05).
  • the milk beverage of the present invention showed a low cumulative urinary excretion compared to sports drinks and distilled water.
  • the cumulative urine excretion amount of the milk drink of this invention and milk is comparable.
  • the milk beverage (hydration supplement) of the present invention absorbs water more rapidly into the living body and rapidly increases the plasma volume than milk. Moreover, it was confirmed that the water retaining effect of the milk beverage (hydration supplement) of the present invention is higher than that of sports drinks and is almost the same as that of milk. Moreover, it turned out that the milk drink (hydration replenishment agent) of this invention has the characteristic that the water

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Abstract

L'invention concerne un agent de réhydratation acide qui contient, comme principes actifs : une lactoprotéine, du sodium, un glucide et un agent stabilisant. L'agent de réhydratation a pour propriété de permettre l'absorption rapide d'eau par un organisme vivant.
PCT/JP2017/006803 2016-02-23 2017-02-23 Agent de réhydratation WO2017146141A1 (fr)

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