WO2017141861A1 - Contenant de distribution et unité de régulation de température - Google Patents

Contenant de distribution et unité de régulation de température Download PDF

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Publication number
WO2017141861A1
WO2017141861A1 PCT/JP2017/005090 JP2017005090W WO2017141861A1 WO 2017141861 A1 WO2017141861 A1 WO 2017141861A1 JP 2017005090 W JP2017005090 W JP 2017005090W WO 2017141861 A1 WO2017141861 A1 WO 2017141861A1
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WO
WIPO (PCT)
Prior art keywords
heat
container
heat storage
wall
temperature
Prior art date
Application number
PCT/JP2017/005090
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English (en)
Japanese (ja)
Inventor
克博 都能
Original Assignee
セルラー・ダイナミクス・インターナショナル・ジャパン株式会社
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Application filed by セルラー・ダイナミクス・インターナショナル・ジャパン株式会社 filed Critical セルラー・ダイナミクス・インターナショナル・ジャパン株式会社
Priority to JP2018500100A priority Critical patent/JPWO2017141861A1/ja
Publication of WO2017141861A1 publication Critical patent/WO2017141861A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • A01N1/0273—Transport containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D39/00—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
    • B65D39/08—Threaded or like closure members secured by rotation; Bushes therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
    • B65D77/0413—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid or semi-rigid and the outer container being of polygonal cross-section formed by folding or erecting one or more blanks, e.g. carton
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
    • B65D81/05—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
    • B65D81/07—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents using resilient suspension means
    • B65D81/075—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents using resilient suspension means the contents being located between two membranes stretched between opposed sides of the package
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/38—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
    • B65D81/3837—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container in the form of a bottle, jar or like container
    • B65D81/3841—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container in the form of a bottle, jar or like container formed with double walls, i.e. hollow
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D15/00—Devices not covered by group F25D11/00 or F25D13/00, e.g. non-self-contained movable devices
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/02—Devices using other cold materials; Devices using cold-storage bodies using ice, e.g. ice-boxes
    • F25D3/06—Movable containers
    • F25D3/08—Movable containers portable, i.e. adapted to be carried personally
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2201/00—Means or constructions for testing or controlling the contents
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B21/00—Machines, plants or systems, using electric or magnetic effects
    • F25B21/02—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
    • F25B21/04—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect reversible
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B2321/00—Details of machines, plants or systems, using electric or magnetic effects
    • F25B2321/02—Details of machines, plants or systems, using electric or magnetic effects using Peltier effects; using Nernst-Ettinghausen effects
    • F25B2321/025—Removal of heat
    • F25B2321/0251—Removal of heat by a gas
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2201/00—Insulation
    • F25D2201/10—Insulation with respect to heat
    • F25D2201/14—Insulation with respect to heat using subatmospheric pressure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
    • F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
    • F25D2303/084—Position of the cold storage material in relationship to a product to be cooled
    • F25D2303/0843—Position of the cold storage material in relationship to a product to be cooled on the side of the product
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
    • F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
    • F25D2303/084—Position of the cold storage material in relationship to a product to be cooled
    • F25D2303/0844—Position of the cold storage material in relationship to a product to be cooled above the product
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
    • F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
    • F25D2303/084—Position of the cold storage material in relationship to a product to be cooled
    • F25D2303/0845—Position of the cold storage material in relationship to a product to be cooled below the product
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2700/00—Means for sensing or measuring; Sensors therefor

Definitions

  • the present invention relates to a transport container and a temperature control device, and more particularly, to a transport container and a temperature control device for a transport container suitable for transporting a sample or a medicine in a predetermined temperature range.
  • tissues and iPS cells collected from patients and the like are processed according to the purpose of treatment, and the cells thus processed are transplanted into the patient.
  • a cell processing center CPC
  • tissue collected from a patient at a medical institution is transported to the CPC, or cells processed by the CPC are sent to the medical institution. Need to be transported.
  • sample state management including the above-described temperature control is required.
  • the vacuum heat insulation panel exhibits high heat insulation performance at the center of the panel, but causes large heat leakage at the end of the panel. For this reason, in a container having a small volume such as a sample transport container, heat leakage at the end portion is larger than the heat insulating effect at the center portion. Therefore, in the transport container disclosed in Patent Document 1, a high heat insulation effect cannot be obtained.
  • the present invention provides a transport container and a temperature control device that can improve heat insulation and maintain the temperature in the storage space in a certain range, thereby reducing the amount of heat storage material used, and The purpose is to shorten the pre-processing time, simplify the temperature control of the heat storage material, and reduce the transportation cost and management effort.
  • the present invention includes an inner wall having a storage space for storing a conveyed product, and an outer wall provided outside the inner wall so as to form a vacuum space between the inner wall and the inner wall.
  • a double wall container having heat insulation, a lid that detachably seals the opening of the double wall container, and an inner peripheral surface of the inner wall so as to surround the transported object in the storage space.
  • a heat storage material having a substantially uniform thickness (in other words, a heat storage material provided uniformly along the inner peripheral surface of the inner wall).
  • the lid has an extension that extends along the outer peripheral surface of the double wall container in a state where the lid is attached to the opening of the double wall container.
  • the lid has an extension that extends along the outer peripheral surface of the double wall container in a state where the lid is attached to the opening of the double wall container.
  • the inner wall has a narrowed portion that protrudes from the inner peripheral surface of the inner wall.
  • the transport container of the present invention having the above-described configuration further includes an auxiliary heat storage material provided on a surface of the lid that faces the storage space.
  • the transport container of the present invention having the above-described configuration further includes a temperature sensor that measures the temperature of the heat storage material.
  • the temperature sensor is provided between the inner wall and the heat storage material.
  • the transport container of the present invention having the above-described configuration further includes a container having thermal conductivity and provided in close contact with the inner peripheral surface of the heat insulating material.
  • the lid includes a sealing material that is in close contact with the opening in a state where the lid is attached to the opening of the double wall container. Is preferred.
  • the transport container further includes a temperature control device that is detachably attached to the storage space and performs heat storage heat treatment on the heat storage material.
  • the transport container of the present invention having the above-described configuration, it is preferable that the transport container further includes a cushioning material provided in the storage space and protecting the transported object from vibration or impact.
  • the present invention surrounds the transported object in the storage space, a heat-insulating container having a storage space for storing a transported object, a heat-insulating lid for detachably sealing the opening of the container. And a heat storage material having a uniform thickness along the inner peripheral surface of the inner wall, and a temperature control device that performs heat storage heat treatment on the heat storage material in a transport container, and is detachably mounted in the storage space
  • a temperature control device comprising: a heat transfer body that transfers heat to the heat storage material; a cooling section that cools the heat transfer body; and a controller that adjusts the temperature of the cooling section.
  • the heat transfer body is formed of a hollow metal member.
  • the heat insulation can be improved and the temperature in the storage space can be maintained within a certain range.
  • the usage-amount of a thermal storage material can be reduced, the pre-processing time of a thermal storage material can be shortened, the temperature control management of a thermal storage material can be simplified, and it becomes possible to reduce conveyance cost and management effort.
  • the transport container 10 includes a double wall container 110, a lid 120, a heat storage material 130, a temperature sensor 140, and a container 150.
  • the temperature control device 16 may be applied to the transport container 10 in order to perform heat storage heat treatment of the heat storage material 130.
  • the double-walled container 110 is a cylindrical container having heat insulation properties, and includes an inner wall 111 and an outer wall 112 as shown in FIG.
  • the double-walled container 110 has a cylindrical shape, but may have an elliptical shape or a rectangular parallelepiped shape, for example. What is necessary is just to select suitably the thickness between the both walls in the surrounding surface of the double wall container 110 according to the capacity
  • the thickness between both walls in the bottom part 115 (part which vacuum-evacuates) of the double wall container 110 may be more than the thickness between both walls in a surrounding surface, and is about 10 mm in this embodiment, for example.
  • the inner wall 111 is a cylindrical metal member, and has a storage space 151 for storing transported items 91 to 93 such as cells inside.
  • the storage space 151 may store an arbitrary number of conveyed items.
  • the conveyed items 91 to 93 may be collectively referred to as the conveyed item 90.
  • the conveyed product 90 may be stored in the storage space 151 in a state of being stored in the secondary container 95.
  • the inner wall 111 has an opening 114 at one edge portion for inserting the conveyed product 90 into the storage space 151 and taking out the conveyed product 90 from the storage space 151.
  • the inner wall 111 has, at the other edge, a bottom 115 that covers the other edge.
  • the inner diameter D11 of the inner wall 111 is substantially uniform from the bottom 115 to the opening 114.
  • the inner diameter D11 of the inner wall 111 is from 80 mm. What is necessary is just to be 150 mm, and it is good also as 100 mm to 125 mm.
  • a threaded portion 116 is formed on the inner peripheral surface of the inner wall 111 near the opening 114.
  • the screw part 116 can be engaged with a screw part 126 formed on the lid 120 to be described later, whereby the double wall container 110 and the lid 120 are fixed.
  • the screw portion may be formed on a surface of the outer wall 112 that faces the inner surface of the lid 120.
  • the edge part which forms the opening part 114 of the inner wall 111 contacts the sealing material 125 provided in the lid
  • the storage space 151 is sealed.
  • the inner wall 111 is formed, for example, by processing stainless steel into a thin plate of 0.2 mm to 0.7 mm, preferably a thin plate of 0.5 mm or less.
  • Stainless steel is a material with relatively low heat conduction.
  • the outer wall 112 is a cylindrical metal member similar to the inner wall 111 and is provided so as to cover the outer side of the inner wall 111.
  • the outer wall 112 is joined in the vicinity of the opening 114 in a state where the space 113 between the outer wall 112 and the inner wall 111 is decompressed. Therefore, the space 113 is a vacuum, and the double-walled container 110 has high heat insulation.
  • the outer wall 112 is formed by processing stainless steel into a thin plate of 0.2 mm to 0.7 mm, preferably 0.5 mm or less, like the inner wall 111.
  • the transport container may be sized according to the cell being transported. In most cases, 1.0 L to 2.0 L is sufficient for the substantial storage capacity of the transport container.
  • a grip portion for the operator to grip may be provided on the outer peripheral surface of the double wall container 110.
  • a sealing mechanism may be provided so that the edge of the opening 114 and the sealing material 125 are in close contact with each other.
  • the sealing mechanism includes, for example, two hook-like members attached to the outer surface of the lid 120 and two annular members attached to the outer surface of the double-walled container 110 corresponding to the hook-like members. It may be constituted by.
  • the sealing mechanism reliably seals the storage space 151 by urging the annular member in a direction opposite to the hook-shaped member in a state where the ring-shaped member is locked to each of the hook-shaped members.
  • the lid 120 has a heat insulating property, and detachably seals the opening 114 of the double-walled container 110.
  • the heat transfer between the storage space 151 of the double wall container 110 and the outside includes the heat conduction in the stainless steel plate constituting the wall material of the double wall container 110 and the heat through the lid 120. Caused by transmission.
  • the inner diameter of the double wall container 110 is at least about 10 cm. Preferably there is.
  • the lid 120 in the present embodiment is configured to include an inner plug 121, a heat insulating material 122, a cap 123, and a sealing material 125, as shown in FIG. 1.
  • the inner plug 121, the heat insulating material 122, and the cap 123 may be integrally formed.
  • the lid 120 may be provided with a conventionally known internal pressure releasing mechanism.
  • the inner plug 121 is a cylindrical hollow member formed of a heat insulating material such as foamed polyurethane and foamed polystyrene.
  • the outer diameter on the top surface side of the inner plug 121 is the same as or slightly larger than the outer diameter of the inner wall 111 of the double wall container 110.
  • the inner plug 121 has an outer diameter slightly smaller than the inner diameter D11 of the inner wall 111 of the double wall container 110 so as to be fitted into the opening 114 of the double wall container 110 on the double wall container 110 side. Therefore, a step is formed on the outer peripheral surface of the inner plug 121.
  • Threaded portion 126 is formed on the outer peripheral surface of inner plug 121 on the double wall container 110 side.
  • the threaded portion 126 engages with the threaded portion 116 formed on the inner wall 111 of the double-walled container 110 in a state where the lid 120 is fitted into the opening 114 of the double-walled container 110, and the lid 120 is doubled. Fix to the wall container 110.
  • the inside plug 121 is filled with a heat insulating material 122 so as to enhance the heat insulating property of the lid 120.
  • the heat insulating material 122 is hard foamed urethane, for example, and has high heat insulating properties.
  • the inner plug 121 is covered with a cap 123.
  • the cap 123 is formed of a material having high heat insulation, such as foamed polypropylene, for example, and contributes to the improvement of the heat insulation performance of the lid 120.
  • foamed polypropylene for example
  • the sealing material 125 abuts on an edge forming the opening 114 in a state where the lid 120 is fitted into the opening 114 of the double wall container 110, and seals the storage space 151 of the double wall container 110.
  • the sealing material 125 is, for example, an annular gasket, and is attached to the inner plug 121 so as to contact a step formed on the outer surface of the inner plug 121.
  • a sealing material 125 is provided on the lid 120 so as to ensure airtightness in the transport container 10 in a state where the lid 120 is engaged with the double wall container 110. Therefore, the lid 120 having the above-described configuration has high heat insulation performance.
  • the cap 123 has an extension 124 that extends along the outer peripheral surface of the double-walled container 110 in a state where the lid 120 is fitted into the opening 114 of the double-walled container 110.
  • the extension portion 124 is for extending a heat insulating creepage distance L1, which will be described later. In other words, it can be said to be a creeping portion.
  • the heat insulation creepage distance L1 is defined as the distance between the heat storage material 130 and the outside of the transport container 10 along the inner surface and the outer surface of the double-walled container 110, as indicated by a broken line in FIG.
  • the heat insulation creepage distance L ⁇ b> 1 defined in this way is determined by how much the lid 120 covers the outer wall 112 of the double wall container 110.
  • the amount of heat QL that flows through the wall surface of the double-walled container 110 and leaks into the double-walled container 110 is the thermal conductivity ⁇ (for example, 0.16 W / cm ⁇ ° C.) of stainless steel that is the material of the wall surface,
  • ⁇ for example, 0.16 W / cm ⁇ ° C.
  • Leakage heat QL thermal conductivity ⁇ ⁇ cross-sectional area S / insulation creepage distance L1
  • the heat insulation creepage distance L1 becomes long and the heat insulation performance is improved.
  • the heat insulation creepage distance L1 is 8 cm or more.
  • the length of the extension part 124 is 1 cm or more.
  • the cap 123 may be further covered with a heat insulating material. Further, the lid 120 may be provided with a mechanism for releasing the airtightness of the storage space 151.
  • the heat storage material 130 is, for example, a latent heat storage material, and maintains the temperature around the heat storage material in the vicinity of the phase change temperature using heat absorption or heat generation associated with the phase change.
  • the heat storage material 130 is disposed along the inner peripheral surface of the inner wall 111 of the double-walled container 110.
  • the heat storage material 130 may be disposed along the bottom surface 115 of the double-walled container 110.
  • the heat storage material 130 has a substantially uniform thickness from the bottom 115 of the inner wall 111 to the vicinity of the opening 114 in order to facilitate heat storage heat treatment described later and to maintain the temperature in the storage space 151 in a certain range during transportation. D13.
  • the substantially uniform thickness is synonymous with the fact that the time required for the heat storage heat treatment of the heat storage material 130 is approximately the same regardless of the portion of the heat storage material 130.
  • the heat storage material 130 is a paraffinic or fatty acid hydrocarbon material such as normal paraffin. With this type of heat storage material, it is possible to obtain a heat storage material that stores heat in a specific temperature range within a range of 0 ° C. to 50 ° C., for example, by varying the composition of the material. Thereby, the temperature in the storage space 151 can be maintained at a desired temperature from the refrigeration temperature to a temperature close to the body temperature.
  • the heat storage material 130 may be a material other than hydrocarbon.
  • a heat storage material that operates in the temperature zone of the freezing region can be used for transporting the sample that is stored frozen.
  • the heat storage material 130 is formed in a sheet shape or a plate shape, and has a substantially uniform thickness.
  • the heat storage material 130 may be formed in a cylindrical shape in advance.
  • the heat storage material 130 is solid after heat storage, and is gelatinous before heat storage. It is preferable that the heat storage material 130 can hold the shape alone without the container 150 described later.
  • the heat storage material 130 having a size corresponding to the size of the storage space 151 of the transport container 10 is prepared, and the heat storage material 130 having an appropriate size is installed around the transported object 90.
  • the heat storage material 130 may be subjected to heat storage heat treatment by a temperature control device 16 described later.
  • a temperature control device 16 described later.
  • the normal paraffin-based heat storage material 130 having a thickness of 2 cm and a weight of 236 g is stored in the double-walled container 110 and is controlled in temperature from 25 ° C. to 18 ° C.
  • the time required for temperature adjustment to the transfer temperature is about 2 hours.
  • the temperature is adjusted to the heat storage and the conveyance temperature. It takes at least 9 to 10 hours. As described above, if the temperature is adjusted moderately at a temperature relatively close to the conveyance temperature, it takes time.
  • the heat storage time is about 4 hours, but it takes 1 hour or more to adjust the temperature to the conveyance temperature. Therefore, it takes at least 5 to 6 hours.
  • heat storage heat treatment is performed at a relatively low temperature in this manner, a large temperature difference is generated between the low temperature portion and the high temperature portion in the heat storage material 130. When such a large temperature difference occurs, it is necessary to warm the part that has been overcooled to the desired transfer temperature, and this work takes time.
  • the heat storage material 130 that has been subjected to the heat storage is solidified and cloudy, and it cannot be determined from the appearance whether the heat storage has been completed. Therefore, the heat storage temperature is adjusted over a time longer than necessary.
  • auxiliary heat storage material As shown in FIG. 5A, a recess 126 is formed on the surface of the inner plug 121 of the lid 120 facing the storage space 151 of the double-walled container 110, and the auxiliary heat insulating material 131 is detachably attached to the recess 126. It is done.
  • the auxiliary heat storage material 131 By providing the auxiliary heat storage material 131 on the upper surface side of the storage space 151, the temperature distribution in the storage space 151 can be made more uniform, and therefore more accurate temperature management can be continued.
  • the auxiliary heat storage material 131 has a disk shape.
  • the thickness of the auxiliary heat storage material 131 is preferably the same as the thickness of the heat storage material 130 in terms of management of the heat storage heat treatment.
  • the auxiliary heat storage material 131 may have a size slightly smaller than the inner diameter D1 of the storage space 151, for example, as shown in FIG. 3, so that the heat storage heat treatment can be performed by the temperature control device 16 together with the heat storage material 130. desirable.
  • a temperature sensor 140 is provided between the double wall container 110 and the heat storage material 130.
  • the temperature sensor 140 is a thermistor, for example.
  • the temperature sensor 140 measures the temperature of the heat storage material 130 and outputs it to an external device such as the temperature control device 16 when the temperature control device 16 is performing heat storage heat treatment. This makes it possible to appropriately manage the time required for heat storage.
  • the temperature sensor 140 measures the temperature of the heat storage material 130 on the double wall container 110 side. More specifically, the temperature sensor 140 measures the temperature of the surface on the side opposite to the temperature control heat transfer body 161 in the thickness direction of the heat storage material 130. This is because the heat storage heat treatment proceeds from the heat transfer body installed in the center of the container toward the outside in the thickness direction of the heat storage material, so that the surface is the last part of the heat storage heat treatment.
  • the temperature control device 16 determines the completion of the heat storage heat treatment based on the output of the temperature sensor 140.
  • Measure the temperature of the part that determines the end of the heat storage material by measuring the temperature of multiple parts in advance under the conditions of the final temperature control specification, determine the part that takes the most time, and install the temperature sensor.
  • An additional temperature sensor may be provided to display the internal temperature of the transport container 10 being transported.
  • the temperature sensor 140 may measure the temperature of the heat storage material 130 when the transported object 90 is transported. This makes it possible to perform temperature management during conveyance.
  • a recorder for recording at least one of temperature, vibration, and atmospheric pressure in the storage space 151 may be installed in the storage space 151. Thereby, it becomes easy to manage the environment of the storage space 151.
  • a container 150 is provided so as to contact the inner surface of the heat storage material 130.
  • the container 150 is made of a thermally conductive metal member such as aluminum, and has a cylindrical shape in the present embodiment.
  • the container 150 is manufactured by forming a thin plate having a thickness of about 1 mm, which has been subjected to a surface treatment such as anodizing, for example, in a cylindrical shape.
  • the bottom part which covers the said edge part in the edge part by the side of the inner wall 115 in the container 150 is formed. Therefore, the container 150 forms a storage space 151.
  • the container 150 may have an elliptical shape or a rectangular parallelepiped shape.
  • the heat storage material 130 is a sheet-like member formed by filling a soft resin film with a gel-like heat storage material.
  • the heat storage material 130 When the heat storage material 130 is inserted into the double wall container 110, it may not be disposed along the inner surface of the inner wall 111 of the double wall container 110. In this case, the heat storage material 130 is reliably disposed along the inner wall 111 of the double-walled container 110 by inserting the container 150 into the heat storage material 130.
  • the container 150 further has a function of uniformly transferring heat from the temperature control heat transfer body 161 of the temperature control device 16 to the heat storage material 130 during the heat storage heat treatment of the heat storage material 130. Such a function contributes to shortening of the heat storage heat treatment of the heat storage material 130. Further, the storage device 150 has a function of evenly transferring the heat from the heat storage material 130 to the transported object 90 in the storage space 151 when the transported object 90 is transported. Such a function contributes to maintaining the temperature in the storage space 151 in a certain temperature range.
  • the bottom of the container 150 is useful for heat storage heat treatment to the auxiliary heat storage material 131 as shown in FIG. 5C, for example.
  • the container 150 may be omitted. In this case, the inside of the heat storage material 130 forms a storage space.
  • the temperature control device 16 includes a temperature control heat transfer body 161, a heat transfer body 162, a cooling element 163, a radiator 166, a housing 164, a controller 168, and a temperature sensor 169. Composed.
  • the temperature control heat transfer body 161 is formed of a metal material having high thermal conductivity, such as aluminum.
  • the temperature control heat transfer body 161 has an inner diameter slightly smaller than the inner diameter of the container 150 so as to be inserted into the storage space 151 along the inner peripheral surface of the container 150.
  • the temperature control heat transfer body 161 has a cylindrical shape so as to conform to the shape of the storage device 150 that forms the storage space 151. Further, since the temperature control heat transfer body 161 is formed hollow, the heat from the cooling element 163 can be efficiently transferred to the heat storage material 130 in a short time. This is because the heat capacity of the temperature control heat transfer body 161 becomes small.
  • the heat transfer body 162 transfers the heat of the cooling element 163 to the temperature control heat transfer body 161.
  • the temperature control heat transfer body 161 is fixed to the heat transfer body 162 with screws through, for example, a heat conductive adhesive.
  • the cooling element 163 is a Peltier element, for example, and cools or heats the heat transfer body 162 based on an instruction from the controller 168.
  • the heat transfer body 162 and the cooling element 163 described above are housed in a casing 164 having heat insulation properties.
  • the housing 164 has a fitting part 165 into which the opening 114 of the double wall container 110 is fitted when the heat storage material 130 in the double wall container 110 is subjected to heat storage heat treatment.
  • the opening 114 of the double-walled container 110 is fitted into the fitting part 165 of the temperature control device 16 so that the inside of the double-walled container 110 is sealed, and heat leakage during heat storage is suppressed. Is done.
  • the heat radiator 166 is a heat sink, for example, and releases heat in the cooling element 163.
  • the fan 167 discharges the heat released from the radiator 166 to the outside of the temperature adjustment device 16.
  • the controller 168 adjusts the temperature of the temperature control heat transfer body 161 based on the temperature information output from the temperature sensor 169 installed in the temperature control heat transfer body 161, and performs heat storage heat treatment. Moreover, based on the temperature information output from the temperature sensor 140 of the transport container 10, the end of the heat storage heat treatment is managed.
  • the transport container 10 is prepared. Then, the fitting between the lid 120 and the double wall container 110 is released, and the lid 120 is removed from the double wall container 110 as shown in FIG. 5A. At the same time, the auxiliary heat storage material 131 is taken out from the recess 126 of the lid 130.
  • the temperature control device 16 is prepared, and as shown in FIG. 5B, the temperature control heat transfer body 161 of the temperature control device 16 is moved from the opening 114 of the double wall container 110 to the storage space 151 (inside the storage device 150. ). At that time, the auxiliary heat storage material 131 is arranged between the temperature control heat transfer body 161 and the bottom of the container 150.
  • the opening 114 of the double-walled container 110 is fitted into the fitting portion 165 of the temperature adjustment device 16, and the cord of the temperature sensor 140 is connected to the controller 168 of the temperature adjustment device 16.
  • the storage portion for storing the cord of the temperature sensor 140 is formed at the inner opening (near the opening 114) of the double-walled container 110 and is not used for heat storage temperature control. Is stored in the storage section.
  • the temperature control apparatus 16 is operated and thermal storage heat processing is started.
  • the controller 168 stores the heat storage material 130 based on the temperature information from the temperature sensor 169. Further, the heat storage end time of the heat storage material 130 is determined based on the temperature information from the temperature sensor 140.
  • the double-walled container 110 is removed from the temperature control device 16 and used for conveyance.
  • the controller 168 also controls the temperature of the heat storage material 130 until the temperature of the heat storage material 130 on the double-walled container 110 side reaches a temperature at which the heat storage material 130 is determined to be set in advance.
  • the controller 168 determines that the temperature information from the temperature sensor 140 has reached the set temperature, the controller 168 should bring the temperature of the temperature control heat transfer body 161 close to the transfer temperature set in advance according to the transfer object 90. Adjust the temperature. Thereafter, when the temperature of the temperature control heat transfer body 161 approaches the transfer temperature, the heat storage transfer preparation is completed and maintained as it is at the transfer preparation temperature, or the temperature control device 16 is removed from the double-walled container 110 and the stored item 90 Used for storage work.
  • the heat storage material 130 is stored alone in the refrigerator. May be.
  • the heat storage material 130 subjected to heat storage is stored in the storage space 151 of the double-walled container 110 as it is.
  • the conveyance container 10 which has high heat insulation is provided.
  • Such a transfer container 10 makes it possible to maintain the transfer object 90 at a desired transfer temperature for a long time.
  • the outer periphery of the conveyed product 90 in which the heat storage material 130 and the auxiliary heat storage material 131 are uniformly stored is covered, the temperature in the storage space 151 can be kept uniform regardless of the place. Thereby, the usage-amount of a thermal storage material can be reduced and size reduction of a conveyance container can be implement
  • the amount of heat storage material 130 used can be reduced, so that the thickness can be reduced and the thickness is uniform. Therefore, the temperature control device 16 is inserted into the double-walled container 110 to directly control the temperature of the heat storage material 130. As a result, it is possible to shorten the time for heat storage.
  • the phase change starts from the surface of the heat storage material 130 closer to the temperature control heat transfer body 161, and finally
  • the double-walled container 110 side is subjected to heat storage heat treatment. Therefore, by installing the temperature sensor 140 between the inner surface of the double-walled container 110 and the heat storage material 130, it is possible to easily determine when to end the heat storage heat treatment.
  • the heat storage material 130 has a uniform thickness, it is considered that the temperature of the heat storage material 130 is adjusted to substantially the same temperature at a position where the distance from the temperature control heat transfer body 161 is equal. Thereby, while being able to perform sufficient thermal storage heat processing in a short time, lack of thermal storage can be avoided.
  • the auxiliary heat storage material 131 is heat-treated by the temperature control device 16 together with the heat storage material 130.
  • the thickness of the auxiliary heat storage material 131 is substantially the same as the thickness of the heat storage material 130, when the heat storage heat treatment to the heat storage material 130 is completed, the heat storage heat treatment to the auxiliary heat storage material 131 is also completed. Therefore, efficient heat storage can be performed.
  • the temperature control device 16 is fitted to the opening 114 of the double wall container 110 at the fitting portion 165. Since the housing 164 in which the fitting portion 165 is formed has a heat insulating property, the inside of the double-walled container 110 is thermally insulated from the outside. This makes it possible to efficiently heat-treat the internal heat storage material 130.
  • the temperature control device 16 is, for example, an electronic cooling type temperature control device provided with a Peltier element, so that the temperature inside the double-walled container 110 can be easily and quickly changed to an arbitrary set temperature.
  • the conveyance container 20 which concerns on 2nd Embodiment is demonstrated.
  • the transport container 20 includes a double wall container 210, a lid 220, a heat storage material 230, and a container 250, similar to the transport container 10 according to the first embodiment. .
  • the difference between the transport container 20 according to the second embodiment and the transport container 10 according to the first embodiment is the structure of the double-walled container 210. That is, the double wall container 210 according to the second embodiment has a narrowed portion 217 protruding from the inner peripheral surface of the inner wall 211.
  • the narrowed portion 217 secures a long heat-insulating creepage distance L2 indicated by a broken line in FIG. 7, reduces the heat transfer cross-sectional area, and further improves the heat insulating property of the transport container 10.
  • the inner diameter of the inner wall 211 extending from the narrowed portion 217 to the opening is smaller than the inner diameter of the inner wall 211 extending from the narrowed portion to the bottom portion 215. This also improves the heat insulation of the transport container 10 by reducing the heat insulation area.
  • a temperature control device similar to the temperature control device 16 is applied to perform the heat storage heat treatment of the heat storage material 230, as in the first embodiment.
  • the heat storage material 230 to be installed on the inner wall 211 must be installed first in a soft state before the heat storage heat treatment. For this reason, in order to perform heat storage heat treatment in a short time, heat storage temperature adjustment processing inside the transport container 20 using a temperature adjustment device similar to the temperature adjustment device 16 is required.
  • the configuration and use method of the temperature control device are the same as those in the first embodiment.
  • the conveyance container 30 which concerns on a modification is demonstrated.
  • the transport container 30 includes a double-walled container 310, a lid 320, a heat storage material 330, a temperature sensor 340, and a container 350, similar to the transport container 10 according to the first embodiment. Further, buffer materials 352 and 353 are provided.
  • Buffer materials 352 and 353 are provided in the storage space 351 in order to protect the stored items 91 to 93 from vibration and impact during transportation. Samples to be transported include samples that may cause quality degradation due to vibration and impact during transport. In order to reduce such vibrations and shocks, buffer materials 352 and 353 are disposed in the storage space 351. There may be one cushioning material or three or more cushioning materials.
  • FIG. 9A to FIG. 9C show an example in which the transport container 10 is sandwiched between the stretchable films 83 and 85 and transported by the packing box 80 that transports the transport container 10.
  • the packing box 80 includes an outer box 81, inner boxes 82 and 84 housed in the outer box 81, and stretchable films 83 and 85 provided on the surface of the inner boxes 82 and 84 facing the transport container 10. ,including. As shown in FIGS.
  • the temperature control apparatus for performing the thermal storage heat processing of the thermal storage material 330 may be used for the conveyance container 30 similarly to 1st Embodiment.
  • the configuration and use method of the temperature control device are the same as those in the first embodiment.

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Abstract

L'invention concerne un contenant de distribution et une unité de régulation de température, qui permettent d'améliorer des propriétés d'isolation thermique tout en étant capables de maintenir la température à l'intérieur d'un espace de stockage dans une plage donnée. Le contenant de distribution selon la présente invention comprend : un contenant à double paroi ayant une paroi interne qui définit un espace de stockage pour stocker un article de distribution et une paroi externe qui est disposée sur le côté externe de la paroi interne de façon à former un espace vide entre elle-même et la paroi interne ; un couvercle qui présente des propriétés d'isolation thermique et peut être attaché et détaché de façon à sceller une ouverture du contenant à double paroi ; et un matériau de stockage de chaleur qui est disposé, dans une épaisseur sensiblement uniforme, le long de la surface périphérique interne de la paroi interne de façon à entourer l'article de distribution dans l'espace de stockage.
PCT/JP2017/005090 2016-02-17 2017-02-13 Contenant de distribution et unité de régulation de température WO2017141861A1 (fr)

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CN110550327A (zh) * 2019-10-08 2019-12-10 苏州贝康医疗器械有限公司 生物样本中转容器

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JPS607822A (ja) * 1983-06-29 1985-01-16 日本酸素株式会社 両口真空二重断熱容器とその製造方法
JPH09206226A (ja) * 1996-02-05 1997-08-12 Nippon Sanso Kk 携帯用断熱容器及びその製造方法
JP2003214781A (ja) * 2002-01-21 2003-07-30 Willwin Kk 冷熱媒体液、蓄熱・蓄冷剤の加熱冷却方法および装置、その容器、その使用方法
JP2004217290A (ja) * 2003-01-17 2004-08-05 Gunze Ltd 細胞組織医療用具の輸送容器
JP2013039102A (ja) * 2011-08-19 2013-02-28 Hitachi Ltd 細胞輸送容器
JP3187215U (ja) * 2013-09-04 2013-11-14 スケーター株式会社 食品用保冷保温容器
JP3195655U (ja) * 2014-11-13 2015-01-29 スケーター株式会社 食品容器

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JPS607822A (ja) * 1983-06-29 1985-01-16 日本酸素株式会社 両口真空二重断熱容器とその製造方法
JPH09206226A (ja) * 1996-02-05 1997-08-12 Nippon Sanso Kk 携帯用断熱容器及びその製造方法
JP2003214781A (ja) * 2002-01-21 2003-07-30 Willwin Kk 冷熱媒体液、蓄熱・蓄冷剤の加熱冷却方法および装置、その容器、その使用方法
JP2004217290A (ja) * 2003-01-17 2004-08-05 Gunze Ltd 細胞組織医療用具の輸送容器
JP2013039102A (ja) * 2011-08-19 2013-02-28 Hitachi Ltd 細胞輸送容器
JP3187215U (ja) * 2013-09-04 2013-11-14 スケーター株式会社 食品用保冷保温容器
JP3195655U (ja) * 2014-11-13 2015-01-29 スケーター株式会社 食品容器

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110550327A (zh) * 2019-10-08 2019-12-10 苏州贝康医疗器械有限公司 生物样本中转容器
CN110550327B (zh) * 2019-10-08 2021-11-23 苏州贝康医疗器械有限公司 生物样本中转容器

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