WO2017102850A1 - Compositions alcooliques à teneur en dichlorhydrate d'octénidine - Google Patents

Compositions alcooliques à teneur en dichlorhydrate d'octénidine Download PDF

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Publication number
WO2017102850A1
WO2017102850A1 PCT/EP2016/081017 EP2016081017W WO2017102850A1 WO 2017102850 A1 WO2017102850 A1 WO 2017102850A1 EP 2016081017 W EP2016081017 W EP 2016081017W WO 2017102850 A1 WO2017102850 A1 WO 2017102850A1
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Prior art keywords
weight
composition according
propanol
ethanol
octenidine dihydrochloride
Prior art date
Application number
PCT/EP2016/081017
Other languages
English (en)
Inventor
Angelo Da Silva Nolasco
Anja David
Katrin Steinhauer
Original Assignee
Schülke & Mayr GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schülke & Mayr GmbH filed Critical Schülke & Mayr GmbH
Priority to EP16822397.2A priority Critical patent/EP3389377A1/fr
Priority to SG11201805046PA priority patent/SG11201805046PA/en
Priority to KR1020187019370A priority patent/KR20180088463A/ko
Priority to AU2016372336A priority patent/AU2016372336B2/en
Priority to CN201680079870.XA priority patent/CN108495552A/zh
Publication of WO2017102850A1 publication Critical patent/WO2017102850A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances

Definitions

  • the invention relates to special alcoholic compositions with a content of octenidine dihydrochloride.
  • the compositions are used in particular for hygienic hand disinfection and for surgical hand disinfection.
  • the invention relates to the use of octenidine dihydrochloride for improving the effectiveness of alcoholic agents for skin antisepsis, for hygienic and surgical hand washing, and for hygienic and surgical hand disinfection.
  • compositions for skin antisepsis, mucosa antisepsis, wound disinfection, hygienic hand disinfection, hygienic hand washing, surgical hand disinfection and surgical hand washing are known.
  • aliphatic alcohols such as ethanol, n-propanol (1 -propanol) and isopropanol (2-propanol), for example, are used for this purpose.
  • Their effectiveness starts after just a short time, particularly if the specified alcohols are present in a comparatively high concentration.
  • compositions with a lower content of aliphatic alcohols are more skin compatible and consequently advantageous for hand disinfection or hand washing.
  • Octenidine dihydrochloride is an active ingredient with demonstrated remanence effect.
  • the product octeniderm ® Schott al.
  • the product octeniman ® comprises 0.1 % by weight of octenidine dihydrochloride, 40.0% by weight of 1 -propanol and 30.0% by weight of 2-propanol.
  • aliphatic alcohols On account of the comparatively high content of aliphatic alcohols, they are only suitable to a limited extent as washing preparations. They are also only virucidal to a limited extent. By contrast, it is advantageous for hygienic hand disinfection if a formulation also has good effectiveness against non-enveloped viruses such as noroviruses, adenoviruses and polioviruses. This would be present in particular in formulations with a high ethanol content.
  • DE 10 2010 054 155 A1 discloses the use of aliphatic alcohols in the production of a disinfectant for preventing contamination of the disinfectant with bacterial spores.
  • An effect of the disinfectant against typical germs of transient and resident skin flora (such as fungi and bacteria, including Staphylococcus aureus) and an effect against viruses, as are important in particular for hygienic and surgical hand disinfection, are not discussed in DE 10 2010 054 155 A1.
  • compositions are used on inanimate surfaces, for example for surface or instrument disinfection, or on animate surfaces, such as the human skin.
  • the object of the present invention was to provide compositions, especially for hygiene hand disinfection and for surgical hand disinfection, which do not automatically have a high content of aliphatic alcohol (but, if desired, can be formulated with a high content of aliphatic alcohol). These compositions should thus also be suitable as washing preparations and, moreover, have good virucidal effectiveness.
  • composition which comprises a) at least 20% by weight of ethanol, b) at least 1 % by weight of n-propanol and c) at least 0.02% by weight of octenidine dihydrochloride.
  • the combination of aliphatic alcohols with octenidine dihydrochloride offers the option, particularly when using ethanol in relatively high concentrations, to utilize its virucidal properties and, by virtue of the content of octenidine dihydrochloride, to obtain a virucidal composition with broad antibacterial effectiveness and a remanence effect.
  • the invention relates to a composition which comprises:
  • octenidine dihydrochloride At least 0.02% by weight of octenidine dihydrochloride.
  • the stated content of ethanol refers to the pure substance (and does not include denaturant present for example in ethanol of technical or medical purity or water).
  • composition as hereinbefore defined comprises up to 95% by weight of ethanol.
  • a preferred amount of a) ethanol is 23 to 95% by weight, preferably 25 to 85% by weight, in particular 30 to 80% by weight, such as for example 34% by weight to 75% by weight of ethanol.
  • the composition comprises less than 78% by weight of ethanol, such as at most 75% by weight of ethanol.
  • composition as hereinbefore defined comprises up to 30% by weight of n-propanol.
  • a preferred amount of b) n-propanol is at least 1 .5% by weight, preferably at least 1 .8% by weight, in particular at least 2.0% by weight, such as 2.0 to 30% by weight or 2.2 to 30% by weight, for example 2.5 to 25% by weight, of n-propanol. Particular preference is given to an amount of 2.5 to 20% by weight of n-propanol, such as 2.5 to 15% by weight of n-propanol.
  • the composition as hereinbefore defined comprises up to 0.25% by weight of octenidine dihydrochloride.
  • the amount of c) octenidine dihydrochloride is 0.025 to 0.25% by weight, preferably 0.03 to 0.2% by weight, in particular 0.035 to 0.18% by weight, such as 0.04 to 0.16% by weight, for example about 0.05 to about 0.15% by weight, of octenidine dihydrochloride.
  • composition as hereinbefore defined comprises:
  • composition according to the invention optionally further comprises:
  • nonionic surfactant preferably amphoteric or nonionic surfactants.
  • nonionic surfactant all suitable nonionic surfactants can be used, where (i) (fatty) alcohol ethoxylates, (ii) sorbitan esters, (iii) alkyl glycosides (in particularly alkyl polyglucosides), (iv) amine oxides and (v) ethylene oxide/propylene oxide block copolymers are preferred.
  • the (i) alcohol polyalkoxylates include fatty alcohol alkoxylates, e.g. isodecyl ethoxylates with various fractions of ethylene oxide, isotridecyl ethoxylates, polyethylene glycol ethers of stearyl, lauryl and cetyl and oleyl alcohol.
  • the alcohols can have been alkoxylated with ethylene oxide, propylene oxide or any desired mixtures of ethylene oxide and propylene oxide.
  • Alcohol polyalkoxylates are known inter alia under the names Lutensol ® , Marlipal ® , Marlox ® , Brij ® and Plurafac ® .
  • nonionic surfactant particular preference is given to lauryl alcohol ethoxylates.
  • nonionic surfactants (ii) used are sorbitan esters, which are mostly present as oleates, stearates, laurates and palmitates and which are referred to as polysorbates (e.g. Tween ® ).
  • the nonionic surfactant can be a (iii) alkyl glycoside, such as an alkyl glucoside (i.e. an alkyl glycoside of glucose), more preferably a C 8 -C 2 o- alkylpolyglucose, in particular a C 8 -Ci 6 -alkylpolyglucose of a fatty alcohol, where a laurylpolyglucose, a decylpolyglucose or a mixture thereof is preferred.
  • an alkyl glucoside i.e. an alkyl glycoside of glucose
  • a C 8 -C 2 o- alkylpolyglucose in particular a C 8 -Ci 6 -alkylpolyglucose of a fatty alcohol, where a laurylpolyglucose, a decylpolyglucose or a mixture thereof is preferred.
  • the carbon chain length in the case of the cocoylpolyglucose is 8 to 16 atoms, in the case of the laurylpolyglucose 12 to 16 carbon atoms and in the case of the decylpolyglucose likewise 8 to 16 carbon atoms.
  • a typical amount of alkyl glycoside is 0.03 to 10% by weight, preferably 0.06 to 5% by weight, in particular 0.1 to 2% by weight.
  • amine oxides which are N-oxides of tertiary amines, include aliphatic amine oxides, cyclic amine oxides (such as N-alkylmorpholine oxide) and aromatic amine oxides (such as pyridine N-oxides).
  • the amine oxide has the general formula
  • R 1 is methyl, ethyl or 2-hydroxyethyl
  • R 2 is methyl, ethyl or 2- hydroxyethyl
  • R 1 and R 2 together can be morpholine
  • R 3 is alkyl having 8 to 18 carbon atoms or R 4 CONH(CH 2 ) n
  • R 4 is alkyl having 8 to 18 carbon atoms and n is in the range from 1 to 10, preferably 1 to 5, more preferably 2 to 4, and in particular 3
  • 2- hydroxyethyl can be condensed with 1 to 2000 ethylene oxide, ethylene oxide/propylene oxide or propylene oxide units.
  • amine oxides are cocamidopropylamine oxide, N-cocomorpholine oxide, decyldimethylamine oxide, dimethylcetylamine oxide, dimethylcocamine oxide, dimethyl hydr. tallow-amine oxide, dimethyllaurylamine oxide, dimethylmyristylamine oxide, (2-hydroxyethyl)cocamine oxide and oleamine oxide. See also "International Cosmetic Ingredient Dictionary and Handbook", 10th edition 2004, volume 3, pages 2268-2275 (Surfactants - Cleansing Agents).
  • This product is sold as Rewominox B 204 by Goldschmidt, Federal Republic of Germany.
  • a typical amount of amine oxide is 0.03 to 10% by weight, preferably 0.06 to 5% by weight, in particular 0.1 to 2% by weight.
  • amphoteric surfactants for example betaines.
  • Suitable betaines are described in EP 560 1 14 A2. Particular preference is given to cocamidopropylbetaine.
  • a typical amount of betaine is 0.03 to 10% by weight, preferably 0.06 to 5% by weight, in particular 0.1 to 2% by weight.
  • quaternary ammonium salts cationic surfactants such as quaternary ammonium salts.
  • quaternary ammonium compounds can be used according to the invention.
  • the quaternary ammonium compound is a dialkyldimethylammonium salt.
  • Quaternary ammonium salts used according to the invention are given by the formula [R 1 R 2 R 3 (CH 3 )N] + [X] " , where R 1 to R 3 can be identical or different and are selected from d- to C 30 -alkyl, -aralkyl, -alkenyl and mixed groups which can have one or more atoms selected from O, S, N and P, where R 1 to R 3 are, for example, C 8 - to Cis-alkyl, benzyl or methyl, preferably C 9 - to Ci 8 -alkyl, benzyl or methyl, such as Ci 6 - alkyl, benzyl or methyl.
  • X is an anion (of an inorganic or organic acid).
  • both anion and cation of the quaternary ammonium salt can be polyvalent ions, which gives rise to a stoichiometry [A (n+) ] m [K (m+) ] n .
  • suitable quaternary ammonium salts are all quaternary ammonium salts of the aforementioned formula known in the prior art, as are disclosed for example in WO 00/63337, to which reference is made here.
  • dialkyldimethylammonium salts for example dialkyldimethylammonium chlorides, the alkyl chains of which are selected independently of one another from C 8 - to Ci 8 -alkyl, preferably C 9 - to Ci 8 -alkyl, such as Ci 6 -alkyl.
  • one of the methyl groups can be an alkoxylated, for example ethoxylated, hydromethyl group.
  • Quaternary ammonium salts preferably used according to the invention are compounds of the formulae [R 1 N(CH 3 ) 3 ] + [X] " , [R 1 R 2 N(CH 3 ) 2 ] + [X] " and [R 1 R 2 R 3 (CH 3 )N] + [X] " , where R 1 to R 3 , independently of one another, are selected from C 8 - to Cie-alkyl and -(CH 2 -CHR 4 0) n -R 5 , where n is a number from 1 to 20, preferably 1 to 5, and R 4 and R 5 , which can be identical or different, are H and/or d- to C 4 -alkyl, preferably H.
  • anions and classes of anions of the quaternary ammonium salts used according to the invention are hydroxide, sulphate, hydrogen sulphate, methosulphate, ethosulphate, lauryl sulphate, lauryl ether sulphate, cellulose sulphate, sulphamate, halide (fluoride, chloride, bromide, iodide), nitrite, nitrate, carbonate, hydrogen carbonate, phosphate, alkyl phosphate, metaphosphate, polyphosphate, thiocyanate (rhodanide), carboxylic acid salt such as benzoate, lactate, acetate, propionate, citrate, succinate, glutarate, adipate, toluenesulphonate (tosylate) and salicylate. Particularly preferred anions are chloride and propionate.
  • the quaternary ammonium salts mecetronium etilsulphate (hexadecyl(ethyl)dimethylammonium ethylsulphate) and benzalkonium chloride are used.
  • composition according to the invention optionally further comprises:
  • Preferred solvents are glycols and water, and mixtures thereof.
  • a preferred solvent is water.
  • composition according to the invention optionally further comprises:
  • compositions according to the invention examples include skincare additives, refatting agents, perfumes, fragrances, thickeners, pH regulators, emollients, humectants and dyes. These are inter alia:
  • polyols which act as skincare additives, refatting agents and humectants, such as glycerol, erythritol, 1 ,2,6-hexanetriol, inositol, lactitol, maltitol, mannitol, methylpropanediol, phytantriol, polyglycerols, sorbitol and xylitol, where glycerol is particularly preferred,
  • glycerol esters preferably coconut fatty acid glycerol monoesters, fatty alcohol esters such as octanoic acid cetearyl ester (cetearyl octanoate) myristic acid isopropyl ester (isopropyl myristate), palmitic acid isopropyl ester (isopropyl palmitate) and fatty acid glyceryl triesters, which act as refatting agents,
  • composition according to the invention preferably comprises one or more refatting agents.
  • compositions according to the invention preferably comprise d) one or more fatty acid esters of monohydric C to C 6 -alkyl alcohol.
  • the alkyl alcohol of the fatty acid ester is selected from methanol, ethanol, n- and isopropanol. Particularly preferably, the alkyl alcohol of the fatty acid ester is specifically isopropanol.
  • the fatty acid of the fatty acid ester is selected from d 0 - to Cie-fatty acids, preferably Ci 2 - to Ci 6 -fatty acids, where the fatty acid is preferably myristic acid.
  • the refatting component is isopropyl myristate.
  • Component preferably myristic acid isopropyl ester, is present in the composition according to the invention preferably in an amount of from 0.02 to 5% by weight, based on the weight of the composition, preferably 0.1 to 4% by weight, more preferably 0.2 to 3% by weight, in particular 0.3 to 2.0% by weight, such as 0.5 to 1 .8% by weight, for example 0.6 to 1 .6% by weight, such as about 0.75 or about 1 .4% by weight.
  • compositions according to the invention have no content of aromatic alcohol (as are obligatorily prescribed according to
  • the content of isopropanol in the compositions is limited and is, for example, less than 25% by weight, preferably less than 20% by weight, in particular less than 15% by weight, such as less than 10% by weight, for example less than 5% by weight, of isopropanol.
  • the content of chlorhexidine derivative is preferably limited and is less than 0.3% by weight, such as less than 0.2% by weight, where compositions according to the invention are particularly preferably free from chlorhexidine derivative.
  • the chlorhexidine derivative is preferably chlorhexidine digluconate.
  • the invention relates to the composition for use in a method for skin antisepsis, hygienic hand disinfection, hygienic hand washing, surgical hand disinfection or surgical hand washing.
  • the invention thus also relates to the use of the composition for skin antisepsis, hygienic hand disinfection, hygienic hand washing, surgical hand disinfection or surgical hand washing.
  • compositions according to the invention takes place in particular in methods for:
  • Hygienic hand disinfection in accordance with EN 1500, ASTM 1 174
  • Hygienic hand washing in accordance with EN 1499
  • the invention thus relates to the application during hygienic hand disinfection in accordance with EN 1500, preferably in accordance with EN 1500:2013.
  • the invention relates to the application of the compositions for hygienic hand disinfection in accordance with ASTM 1 174, preferably in accordance with ASTM 1 174-13.
  • the invention relates to the application of the compositions during hygienic hand washing in accordance with EN 1499, preferably in accordance with EN 1499:2013.
  • the invention relates to the application of the compositions during surgical hand washing in accordance with EN 12791 , preferably in accordance with EN 12791 :2013. Moreover, the invention relates to the application of the compositions during surgical hand washing in accordance with ASTM 1 1 15, preferably in accordance with ASTM 1 1 15-1 1 .
  • the invention relates to the use of octenidine dihydrochloride for improving the remanence effect of a composition which comprises
  • compositions according to the invention are used in particular for controlling transient pathogens in hygienic hand disinfection.
  • compositions according to the invention are effective against human pathogenic bacteria such as Escherichia coli or yeast-like fungi such as Candida albicans.
  • compositions according to the invention are effective against enveloped viruses such as HIV, HBV or HCV and surrogate viruses thereof (BVDV or vaccinia virus) and, in a preferred embodiment, also against non-enveloped viruses such as noroviruses, adenoviruses and polio viruses.
  • the compositions according to the invention are also used for reducing the resident skin flora during surgical hand disinfection. These are preferably bacterial Gram-positive microorganisms which are characterized by not being able to form any endospores, such as Staphylococcus spp. or Corynebacterium spp.
  • Experiment B (46.5% by weight ethanol and 0.05% by weight octenidine dihydrochlonde) demonstrates that octenidine dihydrochlonde in ethanol inhibits the effectiveness for example at 30s.
  • Sorbitol 70% 0.50 0.50 0.50 0.50 0.50 0.50 0.50

Abstract

L'invention concerne une composition contenant a) au moins 20 % en poids d'éthanol, b) au moins 1 % en poids de n-propanol et c) au moins 0,02 % en poids de dichlorhydrate d'octénidine. Ces compositions servent notamment à la désinfection hygiénique des mains et à la désinfection chirurgicale des mains.
PCT/EP2016/081017 2015-12-18 2016-12-14 Compositions alcooliques à teneur en dichlorhydrate d'octénidine WO2017102850A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP16822397.2A EP3389377A1 (fr) 2015-12-18 2016-12-14 Compositions alcooliques à teneur en dichlorhydrate d'octénidine
SG11201805046PA SG11201805046PA (en) 2015-12-18 2016-12-14 Alcoholic compositions with a content of octenidine dihydrochloride
KR1020187019370A KR20180088463A (ko) 2015-12-18 2016-12-14 소정 함량의 옥테니딘 디하이드로클로라이드를 갖는 알코올성 조성물
AU2016372336A AU2016372336B2 (en) 2015-12-18 2016-12-14 Alcoholic compositions with a content of octenidine dihydrochloride
CN201680079870.XA CN108495552A (zh) 2015-12-18 2016-12-14 具有一定含量的奥替尼啶二盐酸盐的醇组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102015122276.0 2015-12-18
DE102015122276.0A DE102015122276A1 (de) 2015-12-18 2015-12-18 Alkoholische Zusammensetzungen mit einem Gehalt an Octenidindihydrochlorid

Publications (1)

Publication Number Publication Date
WO2017102850A1 true WO2017102850A1 (fr) 2017-06-22

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PCT/EP2016/081017 WO2017102850A1 (fr) 2015-12-18 2016-12-14 Compositions alcooliques à teneur en dichlorhydrate d'octénidine

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EP (1) EP3389377A1 (fr)
KR (1) KR20180088463A (fr)
CN (1) CN108495552A (fr)
AU (1) AU2016372336B2 (fr)
DE (1) DE102015122276A1 (fr)
SG (1) SG11201805046PA (fr)
WO (1) WO2017102850A1 (fr)

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WO2022071587A1 (fr) * 2020-10-02 2022-04-07 株式会社 資生堂 Composition désinfectante
US11628129B2 (en) 2017-04-04 2023-04-18 Gojo Industries, Inc. Methods and compounds for increasing virucidal efficacy in hydroalcoholic systems

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WO2021137102A1 (fr) * 2019-12-31 2021-07-08 3M Innovative Properties Company Articles médicaux antimicrobiens à base de sel d'octénidine

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DE102015122276A1 (de) 2017-06-22
CN108495552A (zh) 2018-09-04
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KR20180088463A (ko) 2018-08-03
AU2016372336A1 (en) 2018-07-12
AU2016372336B2 (en) 2019-10-31

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