WO2017102849A1 - Désinfectant alcoolisé permettant de lutter contre les virus - Google Patents

Désinfectant alcoolisé permettant de lutter contre les virus Download PDF

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Publication number
WO2017102849A1
WO2017102849A1 PCT/EP2016/081016 EP2016081016W WO2017102849A1 WO 2017102849 A1 WO2017102849 A1 WO 2017102849A1 EP 2016081016 W EP2016081016 W EP 2016081016W WO 2017102849 A1 WO2017102849 A1 WO 2017102849A1
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WO
WIPO (PCT)
Prior art keywords
weight
disinfectant
ethanol
disinfectant according
amount
Prior art date
Application number
PCT/EP2016/081016
Other languages
English (en)
Inventor
Katrin Steinhauer
Elke Kassens
Angelo Da Silva Nolasco
André RASCH
Annika POERSEL-FREESE
Original Assignee
Schülke & Mayr GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schülke & Mayr GmbH filed Critical Schülke & Mayr GmbH
Priority to AU2016374385A priority Critical patent/AU2016374385A1/en
Priority to SG11201805098XA priority patent/SG11201805098XA/en
Priority to EP16810381.0A priority patent/EP3389376A1/fr
Publication of WO2017102849A1 publication Critical patent/WO2017102849A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

Definitions

  • the invention relates to the use of an alcoholic disinfectant containing oc- tenidine dihydrochloride for controlling viruses.
  • compositions for antisepsis and disinfection of skin, mucosa and wounds are known.
  • aliphatic alcohols such as ethanol, n-propanol (1 -propanol) and isopropanol (2-propanol), for example, are used for this purpose.
  • Their activity begins after just a short time, especially if the stated alcohols are present at comparatively high concentration.
  • compositions with a lower aliphatic alcohol content are more skin-friendly and are advantageous accordingly for hand disinfection or handwashing.
  • Octenidine dihydrochloride is an active ingredient with proven remanence effect.
  • the product octeniderm ® (Schijlke & Mayr GmbH, Norderstedt, Federal Republic of Germany) contains, as medicinally effective ingredients, 0.1 % by weight of octenidine dihydrochloride, 30.0 % by weight of 1 -propanol and 45.0 % by weight of 2-propanol.
  • the product octeniman ® contains 0.1 % by weight of octenidine dihydrochloride, 40.0 % by weight of 1 -propanol and 30.0 % by weight of 2-propanol.
  • DE 10 2010 054 155 A1 discloses the use of aliphatic alcohols in the production of a disinfectant for preventing the contamination of the disinfectant with bacterial spores.
  • An effect of the disinfectant against typical microorganisms of the transient and resident skin flora (such as fungi and bacteria, including Staphylococcus aureus), and an effect against viruses, of the kind important in particular for hygienic and for surgical hand disinfection, are not addressed in DE 10 2010 054 155 A1.
  • compositions are employed on inanimate surfaces, for surface disinfection or instrument disinfection, for example, or on animate surfaces, such as the human skin.
  • the object of the present invention is to provide compositions suitable in particular both for hygienic and for surgical hand disinfection. These compositions are intended, moreover, to be highly virucidal.
  • a disinfectant which comprises ethanol and octenidine dihydrochloride, for controlling viruses.
  • the invention relates to the use of a disinfectant which comprises:
  • the amount of a) ethanol in the disinfectant used in accordance with the invention is preferably at least 50 % by weight, preferably at least 55 % by weight, more preferably at least 60 % by weight, more particularly at least 65 % by weight of ethanol.
  • the disinfectant used in accordance with the invention comprises an amount of a) ethanol of 65 to 98 % by weight, preferably 68 to 95 % by weight, more particularly 70 to 90 % by weight, as for example about 72 % by weight to about 85 % by weight of ethanol, based in each case on the weight of the dis- infectant.
  • the statement of the ethanol content is based on the pure substance (and does not include water or denaturant present in ethanol of technical or medical grade, for example).
  • the disinfectant used in accordance with the invention to com- prise b) octenidine dihydrochloride in an amount of 0.025 to 0.25 % by weight, preferably 0.03 to 0.2 % by weight, more particularly 0.035 to 0.18 % by weight, such as 0.04 to 0.16 % by weight, such as 0.05 to 0.15 % by weight of octenidine dihydrochloride, based in each case on the weight of the disinfectant.
  • the viruses controlled with the disinfectant used in accordance with the inven- tion are preferably selected from enveloped and non-enveloped viruses.
  • Enveloped viruses here are preferably selected from HIV, HBV or HCV or their surrogate viruses (BVDV and/or Vaccinia virus).
  • the disinfectant can be used in accordance with the invention for controlling non-enveloped viruses, the non- enveloped virus being selected preferably from i) noroviruses, ii) adenoviruses or iii) polioviruses.
  • bacteria are additionally controlled by disinfectants used in accordance with the invention, these being preferably Gram-positive, non- endospore-forming bacteria.
  • Gram-positive bacteria of this kind are preferably selected from Staphylococcus spp. and/or Corynebacterium spp.
  • the disinfectant used in accordance with the invention comprises one or more of the following optional components:
  • disinfectants used according to the inven- tion are cationic, anionic, amphoteric and/or nonionic surfactants, preferably amphoteric or nonionic surfactants.
  • nonionic surfactant all suitable nonionic surfactants can be used, where (i) (fatty) alcohol ethoxylates, (ii) sorbitan esters, (iii) alkylglycosides (in particular alkyl- polyglucosides), (iv) amine oxides and (v) ethylene oxide/propylene oxide block co- polymers are preferred.
  • the (i) alcohol polyalkoxylates include fatty alcohol alkoxylates, e.g. isodecyl ethoxylates with various fractions of ethylene oxide, isotridecyl ethoxylates, polyethylene glycol ethers of stearyl, lauryl and cetyl and oleyl alcohol.
  • the alcohols can have been alkoxylated with ethylene oxide, propylene oxide or any desired mixtures of ethylene oxide and propylene oxide.
  • Alcohol polyalkoxylates are known inter alia under the names Lutensol ® , Marlipal ® , Marlox ® , Brij ® and Plurafac ® .
  • nonionic surfactant particular preference is given to lauryl alcohol ethoxylates.
  • nonionic surfactants (ii) used include sorbitan esters, which are mostly present as oleates, stearates, laurates and palmitates and which are referred to as polysorbates (e.g. Tween ® ).
  • the nonionic surfactant can be a (iii) alkylglycoside, such as an alkyl- glucoside (i.e. an alkylglycoside of glucose), more preferably a C 8 -C 2 o-alkylpolyglucose, in particular a C 8 -Ci 6 -alkylpolyglucose of a fatty alcohol, where a laurylpolyglucose, a decylpolyglucose or a mixture thereof is preferred.
  • an alkyl- glucoside i.e. an alkylglycoside of glucose
  • a C 8 -C 2 o-alkylpolyglucose in particular a C 8 -Ci 6 -alkylpolyglucose of a fatty alcohol, where a laurylpolyglucose, a decylpolyglucose or a mixture thereof is preferred.
  • the carbon chain length in the case of the cocoylpolyglucose is 8 to 16 atoms, in the case of the laurylpolyglucose 12 to 16 carbon atoms and in the case of the decylpolyglucose likewise 8 to 16 carbon atoms.
  • a typical amount of alkylglycoside is 0.03 to 10% by weight, preferably 0.06 to 5% by weight, in particular 0.1 to 2% by weight.
  • amine oxides which are N-oxides of tertiary amines, include aliphatic amine oxides, cyclic amine oxides (such as N-alkylmorpholine oxide) and aro- matic amine oxides (such as pyridine N-oxides).
  • the amine oxide has the general formula
  • R 1 is methyl, ethyl or 2-hydroxyethyl
  • R 2 is methyl, ethyl or 2- hydroxyethyl
  • R 1 and R 2 together can be morpholine
  • R 3 is alkyl having 8 to 18 carbon atoms or R 4 CONH(CH 2 ) n
  • R 4 is alkyl having 8 to 18 carbon atoms and n is in the range from 1 to 10, preferably 1 to 5, more preferably 2 to 4, and in particular 3
  • 2- hydroxyethyl can be condensed with 1 to 2000 ethylene oxide, ethylene ox- ide/propylene oxide or propylene oxide units.
  • amine oxides are cocamidopropylamine oxide, N-cocomorpholine oxide, decyldimethylamine oxide, dimethylcetylamine oxide, dimethylcocamine oxide, dimethyl hydr. tallow-amine oxide, dimethyllaurylamine oxide, dimethylmyristylamine oxide, (2-hydroxyethyl)cocamine oxide and oleamine oxide. See also "International Cosmetic Ingredient Dictionary and Handbook", 10th edition 2004, volume 3, pages 2268-2275 (Surfactants - Cleansing Agents).
  • This product is sold as Rewominox B 204 by Goldschmidt, Federal Republic of Germany.
  • a typical amount of amine oxide is 0.03 to 10% by weight, preferably 0.06 to 5% by weight, in particular 0.1 to 2% by weight.
  • amphoteric surfactants for example be- taines.
  • Suitable betaines are described in EP 560 1 14 A2. Particular preference is given to cocamidopropylbetaine.
  • a typical amount of betaine is 0.03 to 10% by weight, preferably 0.06 to 5% by weight, in particular 0.1 to 2% by weight.
  • quaternary ammonium salts cationic surfactants such as quaternary ammonium salts.
  • quaternary ammonium compounds can be used according to the invention.
  • the quaternary ammonium compound is a dialkyldimethylammonium salt.
  • Quaternary ammonium salts used according to the invention are given by the formula [R 1 R 2 R 3 (CH 3 )N] + [X] " , where R 1 to R 3 can be identical or different and are selected from d- to C 30 -alkyl, -aralkyl, -alkenyl and mixed groups which can have one or more atoms selected from O, S, N and P, where R 1 to R 3 are, for example, C 8 - to Ci 8 - alkyl, benzyl or methyl, preferably C 9 - to Ci 8 -alkyl, benzyl or methyl, such as Ci 6 -alkyl, benzyl or methyl.
  • X is an anion (of an inorganic or organic acid).
  • both anion and cation of the quaternary ammonium salt can be polyvalent ions, which gives rise to a stoichiometry [A (n+) ] m [K (m+) ] n .
  • suitable quaternary ammonium salts are all quaternary ammonium salts of the aforementioned formula known in the prior art, as are dis- closed for example in WO 00/63337, to which reference is made here.
  • dialkyldimethylammonium salts for example dialkyldimethyl- ammonium chlorides, the alkyl chains of which are selected independently of one another from C 8 - to Cis-alkyl, preferably C 9 - to Ci 8 -alkyl, such as Ci 6 -alkyl.
  • one of the methyl groups can be an alkoxylated, for ex- ample ethoxylated, hydroxymethyl group.
  • Quaternary ammonium salts preferably used according to the invention are compounds of the formulae [R 1 N(CH 3 ) 3 ] + [X] " , [R 1 R 2 N(CH 3 ) 2 ] + [X] " and [R 1 R 2 R 3 (CH 3 )N] + [X] " , where R 1 to R 3 , independently of one another, are selected from C 8 - to Cis-alkyl and -(CH 2 -CHR 4 0) n -R 5 , where n is a number from 1 to 20, preferably 1 to 5, and R 4 and R 5 , which can be identical or different, are H and/or d- to C 4 -alkyl, preferably H.
  • anions and classes of anions of the quaternary ammonium salts used according to the invention are hydroxide, sulphate, hydrogen sulphate, methosul- phate, ethosulphate, lauryl sulphate, lauryl ether sulphate, cellulose sulphate, sulpha- mate, halide (fluoride, chloride, bromide, iodide), nitrite, nitrate, carbonate, hydrogen carbonate, phosphate, alkyl phosphate, metaphosphate, polyphosphate, thiocyanate (rhodanide), carboxylic acid salt such as benzoate, lactate, acetate, propionate, citrate, succinate, glutarate, adipate, toluenesulphonate (tosylate) and salicylate. Particularly preferred anions are chloride and propionate.
  • the quaternary ammonium salts mecetronium etilsul- phate (hexadecyl(ethyl)dimethylammonium ethylsulphate) and benzalkonium chloride are used.
  • the disinfectant used according to the invention optionally comprises
  • solvents are glycols and water, and mixtures thereof.
  • a preferred solvent is water.
  • active ingredients and/or excipients which can optionally be present in disinfectants used according to the invention are skincare additives, refatting agents, perfumes, fragrances, thickeners, pH regulators, humectants and dyes. These are inter alia:
  • Polyols which act as skincare additives, refatting agents and humectants, such as glycerol, erythritol, 1 ,2,6-hexanetriol, inositol, lactitol, maltitol, mannitol, methylpropanediol, phytantriol, polyglycerols, sorbitol and xylitol, where glycerol is particularly preferred,
  • Glycerol esters preferably coconut fatty acid glycerol monoesters, myristic acid isopropyl ester, palmitic acid isopropyl ester, and fatty acid glycerol triesters, which act as refatting agents,
  • the disinfectant used according to the invention preferably comprises one or more refatting agents.
  • Refatting agents preferably comprises one or more refatting agents.
  • Disinfectants used according to the invention preferably comprise c) one or more fatty acid esters of monohydric C to C 6 -alkyl alcohol.
  • the alkyl alcohol of the fatty acid ester is selected from methanol, ethanol, n- and isopropanol. Particularly preferably, the alkyl alcohol of the fatty acid ester is specifically isopropanol.
  • the fatty acid of the fatty acid ester is selected from d 0 - to Cie-fatty acids, preferably Ci 2 - to Ci 6 -fatty acids, where the fatty acid is preferably myristic acid.
  • the refatting component c) is isopropyl myristate.
  • Component c preferably myristic acid isopropyl ester, is present in the disinfectant used according to the invention preferably in an amount of from 0.02 to 5% by weight, based on the weight of the disinfectant used, preferably 0.1 to 4% by weight, more preferably 0.2 to 3% by weight, in particular 0.3 to 2.0% by weight, such as 0.5 to 1 .8% by weight, for example 0.6 to 1 .6% by weight, such as about 0.75 or about 1 .4% by weight.
  • disinfectants used according to the invention have no content of aromatic alcohol (as are obligatorily prescribed according to DE 10 201 1 077 432 A1 , if aliphatic alcohol is present).
  • the content of isopropanol in the disinfectants used in accordance with the invention is limited and is, for example, less than 25% by weight, preferably less than 20% by weight, in particular less than 15% by weight, such as less than 10% by weight, for example less than 5% by weight, of iso- propanol.
  • chlorhexidine derivative is preferably limited and is less than 0.3% by weight, such as less than 0.2% by weight, where disinfectants used according to the invention are particularly preferably free from chlorhexidine derivative.
  • the chlorhexidine derivative the presence of which is preferably limited according to the invention and the presence of which in the disinfectant used according to the invention is particularly preferably excluded is preferably chlorhexidine digluconate.
  • the disinfectants are preferably used on the skin to control viruses, particularly the human skin.
  • the stated disinfectants are typically employed in accordance with the invention in a method for skin antisepsis, hygienic hand disinfection or surgical hand disinfection.
  • the disinfectant possesses a remanence effect on the skin.
  • the invention relates to a disinfectant which comprises a) at least 45 % by weight of ethanol and
  • the invention also relates to a disinfectant which consists in for 100% by weight:
  • the stability of solutions of the active ingredients chlorhexidine digluconate (CHX, comparative) and octenidine dihydrochloride (OCT, inventive) in ethanol and wa- ter was investigated. This was done by preparing samples of the active ingredients at a concentration of about 0.8 % by weight (chlorhexidine digluconate) and 0.1 % by weight octenidine dihydrochloride) in water and in ethanol and storing them in glass bottles (at 25°C and at 40°C) for 3 months (the elevated-temperature storage simulates long-term storage).
  • ethanol 3 different types, namely i) undenatured ethanol at 96% by volume, ii) ethanol at 96% by volume, denatured with 1 % methyl ethyl ketone (MEK), and iii) ethanol at 96% by volume, denatured with 1 % diethyl phthalate (DEP), in order to investigate any possible influence of the denaturant on the storage stability.
  • MEK methyl ethyl ketone
  • DEP diethyl phthalate
  • Chlorhexidine digluconate was quantified by means of Ultra Performance Liquid Chromatography. Separation took place on a RP18 phenyl phase. Eluents used were 0.1 % phosphoric acid and acetonitrile in a gradient. Detection took place using a photo- diode array detector. Quantification was carried out by means of an external standard.
  • Octenidine dihydrochloride was quantified by means of High Pressure Liquid Chromatography. Separation took place on a RP18 hybrid phase. Eluents used were 0.1 % phosphoric acid and methanol in a gradient. Detection took place using a photo- diode array detector. Quantification was carried out by means of an internal standard.
  • the octenidine dihydrochloride active ingredient present in disinfectants used in accordance with the invention is stable in ethanol solution as well, even where the concentration of ethanol is high, where the temperature is elevated, and even over a period of 3 months.
  • the presence of the methyl ethyl ketone denaturant has no adverse effect on the stability (Fig. 4-6).

Abstract

L'invention concerne l'utilisation d'un désinfectant comprenant a) au moins 45 % en poids d'éthanol et b) au moins 0,02 % en poids de dichlorhydrate d'octénidine pour lutter contre les virus. Les désinfectants de ce type se caractérisent par une bonne stabilité au stockage.
PCT/EP2016/081016 2015-12-18 2016-12-14 Désinfectant alcoolisé permettant de lutter contre les virus WO2017102849A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2016374385A AU2016374385A1 (en) 2015-12-18 2016-12-14 Alcoholic disinfectant for virus control
SG11201805098XA SG11201805098XA (en) 2015-12-18 2016-12-14 Alcoholic disinfectant for virus control
EP16810381.0A EP3389376A1 (fr) 2015-12-18 2016-12-14 Désinfectant alcoolisé permettant de lutter contre les virus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102015122263.9A DE102015122263A1 (de) 2015-12-18 2015-12-18 Alkoholisches Desinfektionsmittel für die Bekämpfung von Viren
DE102015122263.9 2015-12-18

Publications (1)

Publication Number Publication Date
WO2017102849A1 true WO2017102849A1 (fr) 2017-06-22

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PCT/EP2016/081016 WO2017102849A1 (fr) 2015-12-18 2016-12-14 Désinfectant alcoolisé permettant de lutter contre les virus

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EP (1) EP3389376A1 (fr)
AU (1) AU2016374385A1 (fr)
DE (1) DE102015122263A1 (fr)
SG (1) SG11201805098XA (fr)
WO (1) WO2017102849A1 (fr)

Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
WO2021197646A1 (fr) * 2020-03-31 2021-10-07 Schülke & Mayr GmbH Composition aqueuse contenant de l'octénidine pour le traitement et/ou la prévention d'une exacerbation de maladies provoquées par une infection au coronavirus

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EP1683416A1 (fr) * 2005-01-19 2006-07-26 Air Liquide Santé (International) Compositions alcooliques pour la désinfection
US20120070510A1 (en) * 2005-08-26 2012-03-22 Barbara Krug Wound and mucous membrane disinfectant
US20140205360A1 (en) * 2013-01-23 2014-07-24 Carefusion 2200, Inc. Antiseptic applicator
US20140261454A1 (en) * 2013-03-15 2014-09-18 Carefusion 2200, Inc. Tinted antiseptic solutions having improved stability
US20150297764A1 (en) * 2014-01-08 2015-10-22 Carefusion 2200, Inc. Systems, methods, and devices for sterilizing antiseptic solutions
EP2952213A1 (fr) * 2014-05-26 2015-12-09 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Kit de coloration de régions désinfectées d'une surface

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JP3515821B2 (ja) 1994-10-21 2004-04-05 株式会社資生堂 消毒用組成物
GB2348885A (en) 1999-04-16 2000-10-18 Reckitt & Colman Inc Hard surface cleaning and disinfecting composition
DE102010054155A1 (de) 2010-12-10 2012-06-14 Schülke & Mayr GmbH Verwendung von aliphatischen Alkoholen bei der Herstellung eines Desinfektionsmittels zur Verhinderung der Verunreinigung des Desinfektionsmittels mit bakteriellen Sporen
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EP1683416A1 (fr) * 2005-01-19 2006-07-26 Air Liquide Santé (International) Compositions alcooliques pour la désinfection
US20120070510A1 (en) * 2005-08-26 2012-03-22 Barbara Krug Wound and mucous membrane disinfectant
US20140205360A1 (en) * 2013-01-23 2014-07-24 Carefusion 2200, Inc. Antiseptic applicator
US20140261454A1 (en) * 2013-03-15 2014-09-18 Carefusion 2200, Inc. Tinted antiseptic solutions having improved stability
US20150297764A1 (en) * 2014-01-08 2015-10-22 Carefusion 2200, Inc. Systems, methods, and devices for sterilizing antiseptic solutions
EP2952213A1 (fr) * 2014-05-26 2015-12-09 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Kit de coloration de régions désinfectées d'une surface

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AU2016374385A1 (en) 2018-07-12
SG11201805098XA (en) 2018-07-30
DE102015122263A1 (de) 2017-06-22

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