WO2017010667A1 - 치열교정부재에 사용하기 위한 수용성 또는 생분해성 조성물 - Google Patents

치열교정부재에 사용하기 위한 수용성 또는 생분해성 조성물 Download PDF

Info

Publication number
WO2017010667A1
WO2017010667A1 PCT/KR2016/005054 KR2016005054W WO2017010667A1 WO 2017010667 A1 WO2017010667 A1 WO 2017010667A1 KR 2016005054 W KR2016005054 W KR 2016005054W WO 2017010667 A1 WO2017010667 A1 WO 2017010667A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
orthodontic
biodegradable
water
soluble
Prior art date
Application number
PCT/KR2016/005054
Other languages
English (en)
French (fr)
Inventor
김태경
오명환
김윤기
Original Assignee
(주) 베리콤
김태경
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020150100987A external-priority patent/KR101591015B1/ko
Application filed by (주) 베리콤, 김태경 filed Critical (주) 베리콤
Publication of WO2017010667A1 publication Critical patent/WO2017010667A1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12—Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/14—Brackets; Fixing brackets to teeth
    • A61C7/16—Brackets; Fixing brackets to teeth specially adapted to be cemented to teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12—Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/28—Securing arch wire to bracket
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/10—Esters; Ether-esters
    • C08K5/101—Esters; Ether-esters of monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/12—Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity
    • C08L101/14—Compositions of unspecified macromolecular compounds characterised by physical features, e.g. anisotropy, viscosity or electrical conductivity the macromolecular compounds being water soluble or water swellable, e.g. aqueous gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/16—Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00

Definitions

  • the present invention relates to water-soluble or biodegradable compositions, and more particularly, to water-soluble or biodegradable compositions for use in orthodontic members.
  • the brackets have the ability to guide the teeth to slide along the wires while transferring the restoring force from the wires that are bent in the form of a crooked line, but because of the relatively large and complex structure of the brackets It is very inconvenient, and during treatment, the bracket.
  • An object of the present invention is to provide a composition for a water-soluble or biodegradable orthodontic member.
  • Another object of the present invention is water solubility or biodegradability for use in orthodontic members that dissolve or biodegrade in the oral cavity to provide a playable wire. To provide a composition.
  • a water-soluble or biodegradable substance According to an aspect of the present invention, a water-soluble or biodegradable substance
  • composition for orthodontic members comprising a solvent
  • composition for orthodontic members is water-soluble or biodegradable.
  • the water-soluble or biodegradable substance may be gelatin, starch, starch derivative, salose, salulose derivative, vegetable gum, agar, algin, alginate, carrageenan, chitosan, chitosan derivative, pectin, dextran, hyaluronic acid.
  • the water-soluble or biodegradable substance may also be used in the gelatin, starch, starch derivatives,
  • Salulose cellulose derivative, vegetable gum, agar, algin, alginate, carrageenan, chitosan, chitosan derivative, pectin, dextran, hyaluronic acid, polyacrylamide, polyvinylpyrrolidone, polyvinyl alcohol,
  • polyacrylamide polyvinylpyrrolidone
  • polyvinyl alcohol For one or more 100 parts by weight selected from polyacrylic acid, polyethylene glycol, polypropylene glycol, polyethylene oxide, polypropylene oxide, biodegradable polyamide, biodegradable polyurethane, and biodegradable polyester, It may further comprise 1 to 200 parts by weight of the compound represented by.
  • n is any one of 1 to 8.
  • the water-soluble or biodegradable substance may include a compound represented by the following Chemical Formula 2.
  • R is independently a hydrogen atom, a deuterium atom, a C1 to C6 alkyl group, or a C1 to C6 hydroxyalkyl group, and ⁇ is a repeating unit.
  • the number average molecular weight of the compound represented by Formula 2 is 1,000 to 9,000,000.
  • the compound represented by Formula 2 may be hydroxypropyl methyl sal.
  • the hydroxypropyl methyl cell has a degree of substitution of 15 to 30% of the methoxy group, and a degree of substitution of 4 to 32% of the hydroxypropoxy.
  • the hydroxypropyl methylcell may have a viscosity of 1 to 35 mPa ⁇ s at a temperature of 20 ° C. and a 2% by weight aqueous solution.
  • the solvent may further include linear or pulverized C 2 to C 9 alcohols.
  • composition for orthodontic members may further include at least one stabilizer selected from sorbate, salicylate and benzoate salts.
  • composition for orthodontic members may further include a pigment.
  • the orthodontic member is a tube-type, hollow polygonal equiangular shape, hollow polygonal pyramid shape, augmented pyramid shape or funnel type orthodontic member,
  • the orthodontic member may comprise the water soluble or biodegradable material.
  • the orthodontic member may include a wire in the hollow.
  • a composition for water-soluble or biodegradable orthodontic members can be provided.
  • is soluble or biodegradable in the mouth according to the present invention can provide a water-soluble or biodegradable compositions for use in the orthodontic member to provide a clearance that can move the wire.
  • FIG. 1 is a schematic diagram illustrating a tubular shape and a rectangular column shape in the form of an orthodontic member using a composition according to an embodiment of the present invention.
  • FIG. 2 is a view showing a water-soluble or biodegradable tubular tooth calibration member using a composition according to one embodiment of the present invention, a conventional bracket or a conventional small metal hollow tube. It is a schematic representation of the side section of the tooth.
  • FIG 3 shows a mark using a composition according to an embodiment of the present invention.
  • FIG. 4 is a view illustrating a combination of wires using a composition according to an embodiment of the present invention.
  • FIG. 6 shows a mark using a composition according to an embodiment of the present invention.
  • FIG. 7 shows the clinical trial of the orthodontic calibration using the water-soluble tube-type orthodontic member using the composition of Example 3 of the present invention.
  • Example 8 is a water-soluble tube type using a composition different from Example 3 of the present invention.
  • Example 9 shows a clinical test procedure of orthodontic treatment using a water-soluble tube-type orthodontic member using the composition of Example 4 of the present invention.
  • Example 10 is a water-soluble flow type using the composition according to Example 4 of the present invention.
  • FIG. 11 shows the results of orthodontic calibration using conventional brackets.
  • FIG. 12 shows a photo of an orthodontic calibration using a metal tube in the form of a conventional hollow tube.
  • composition for orthodontic members of the present invention is water-soluble or biodegradable; and in addition, the coating composition for orthodontic members may be used to coat orthodontic wires or to manufacture orthodontic members having hollows.
  • the orthodontic member composition may include 10 to 100 parts by weight of a water-soluble or biodegradable substance; and 20 to 990 parts by weight of a solvent containing water;
  • the water-soluble or biodegradable substance may be any substance which can be decomposed in the oral cavity.
  • the water-soluble or biodegradable substance is gelatin, starch, starch derivative, salose, cellulose derivative, Vegetable gum, baby, algin, alginate, carrageenan, chitosan, chitosan derivative, pectin, textlan,
  • Hyaluronic acid polyacrylamide, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid, polyethylene glycol, polypropylene glycol,
  • It may be at least one selected from polyethylene oxide, polypropylene oxide, biodegradable polyamide, biodegradable polyurethane and biodegradable polyester.
  • the biodegradable polyamide may be polylactic acid or modified polylactic acid.
  • the water-soluble or biodegradable substance may also be used in the gelatin, starch, starch derivative,
  • polyacrylamide, polyvinylpyrrolidone, polyvinyl alcohol For one or more 100 parts by weight selected from polyacrylic acid, polyethylene glycol, polypropylene glycol, polyethylene oxide, polypropylene oxide, biodegradable polyamide, biodegradable polyurethane, and biodegradable polyester, It may further comprise 1 to 200 parts by weight of the compound represented by.
  • n is any one of 1 to 8.
  • the compound represented by Chemical Formula 1 may be sorbbiol and glycerin. More preferably, the water-soluble or biodegradable substance may include 5 to 100 parts by weight of glycerin and 1 to 100 parts by weight of sorbine, based on 100 parts by weight of gelatin.
  • the water-soluble or biodegradable substance may further include 1 to 250 parts by weight of purified water.
  • the gelatin may have a jelly strength of 30 to 500 bloom and preferably 100 to 400 bloom.
  • Jelly strength is a representative physical property of gelatin.
  • the Bloom Value is used to express the strength of gelatin, and the jelly strength is 6.67 according to the British Standard (BS 757).
  • water-soluble or biodegradable substance is represented by the following formula (2)
  • It may contain a compound of the cellulose derivative.
  • R is independently a hydrogen atom, a deuterium atom, a C1 to C6 alkyl group, or a C1 to C6 hydroxyalkyl group, n is a repeating unit.
  • the number average molecular weight of the compound represented by 2 is 1,000 to 9,000,000.
  • the polyethylene glycol is preferably a solid having a weight average molecular weight of 1,000 to 100,000.
  • the water-soluble or biodegradable polymer may include modified starch and vegetable gum.
  • the compound represented by Chemical Formula 2 may be hydroxypropylmethyl salose.
  • the hydroxypropyl methyl sal has a degree of substitution of 15 to 15 methoxy groups.
  • Viscosities in concentrations can be from 1 to 35 mPa ⁇ s.
  • the solvent may further include linear or pulverized C2 to C9 alcohols, wherein the increase ratio of water and alcohol in the solvent may be 100: 0 to 5:95.
  • composition for orthodontic member may further include at least one stabilizer selected from sorbate, salicylate and benzoate.
  • the content of the stabilizer may include 01 to 5 parts by weight with respect to 100 parts by weight of the water-soluble or biodegradable substance.
  • the content of the stabilizer is less than 0.01, the preservative effect is not exceeded. It does not lower the mechanical properties of the member.
  • composition for orthodontic members may additionally contain pigments.
  • the pigments include natural food colors, tar food foods, beta carotene, copper sulfate,
  • It may be ferric oxide, caramel, copper, iron chlorophyllin sodium or titanium oxide.
  • the orthodontic coating composition may further include 0.1 to 5 parts by weight of the surfactant.
  • the surfactant is polyethylene glycol, polysorbate, fatty acid.
  • Monoglycerol esters fatty acid polyglycol esters, fatty acid sorbitan esters, fatty acid sucrose esters, fatty acid alkanolamides, polyethylene glycol condensed nonionic surfactants.
  • the polyethylene glycol may be a solid having a molecular weight of 1,000 to 100,000.
  • FIG. 1 is a schematic diagram of a lubricated orthodontic member using a composition according to an embodiment of the present invention.
  • the orthodontic member using the composition of the present invention is a tube, hollow polygonal column, hollow polygonal pyramidal, hollow park pyramid or funnel type and contains water-soluble or biodegradable materials.
  • the tubular orthodontic member has an inner diameter of 0.2 to 1.0 mm and a thickness of 0.001 to 0.5 mm.
  • the cross section of the hollow polygonal orthodontic member is a hollow polygon, and the diameter of the circle inscribed in the hollow polygonal shape is 0.2 to 1.0 mm. Is preferably 0.001 to 0.5 mm. However, the inner diameter and diameter may vary depending on the diameter of the wire to be inserted into the enlargement of the orthodontic member.
  • the hollow polygonal pillar is n-angular polygonal, n may be one of 3 to 20 integers, preferably 4 to 15, and more preferably 4 to 8 integers. Preferably it may be a four-hole quadrangular prism.
  • the minimum inner attention to the maximum inner diameter (E) of the hollow park pyramidal orthodontic member The ratio of diameter (e) (E / e, q) can be Kq ⁇ 10, preferably 2 ⁇ q ⁇ 5,
  • the cross section of the hollow polygonal truncated pyramidal orthodontic member is a polygon of hollow, and the ratio (F / f, p) of the minimum diameter (f) to the maximum diameter (F) of the circle circumscribed to the polygon of the hollow is 1 ⁇ 10, preferably 2 ⁇ p ⁇ 5, more preferably 3 ⁇ p ⁇ 4.
  • the hollow of the hollow polygonal pyramid is an n-pyramidal pyramid, ⁇ can be any one of 3 to 20 integers, preferably 4 to 15, and more preferably 4 to 8 integers.
  • the funnel-shaped orthodontic member includes a hollow truncated cone coupled to one end of a hollow cylindrical cylinder, wherein the hollow cylinder has a larger inner diameter than the maximum inner diameter (D) of the hollow truncated cone.
  • the ratio (D / d, r) of the diameter (d) may be l ⁇ r ⁇ 10.
  • the ratio may be preferably 2 ⁇ r ⁇ 5, and more preferably 3 ⁇ r ⁇ 4.
  • the orthodontic member may be shaped to include a hollow polygonal pyramid coupled to one end, such as an enhanced polygonal polygon, and the maximum diameter (C) of the circle circumscribed to the polygon of the hollow, which is a cross-section of the hollow polygonal pyramid.
  • the ratio (C / c, s) of the diameter (c) may be l ⁇ s ⁇ 10, preferably 2 ⁇ s ⁇ 5, and more preferably 3 ⁇ s ⁇ 4.
  • the orthodontic complex 20 including the wire 30 is manufactured by inserting the wire 30 into the orthodontic member 10 and attaching the wire wrapped around the member to the teeth using resin on a crooked tooth. Restorative force is generated in wires that are bent and twisted in the form of crooked teeth, and the resin is transferred to the teeth with the corrective force to move the tooth into the medium.
  • the orthodontic member is water-soluble or biodegradable, and melts in the oral cavity, a gap is formed between the wire and the resin, so that the teeth can slide and move along the wire.
  • the orthodontic member can be made transparent for the convenience of work, or can be manufactured in white, red, blue, yellow, green and a mixture of these, specifically transparent or white, black, red, yellow or red. Yellow, yellow green, green, cyan, blue, blue purple, purple or reddish purple can be manufactured.
  • the orthodontic member 10 may mark marks 100, 200, and 300 for convenience of work.
  • center portion is displayed on the basis of the length direction of the orthodontic member 10.
  • It may be a center mark 100, a work mark 200 for displaying a distance from the intensifier, or an end mark 300 for displaying an end.
  • center mark may be displayed in a predetermined color according to the size of the inner diameter or the outer diameter of the orthodontic member.
  • the augmentation mark may have a thickness of 0.1 to 5 mm.
  • the work mark is one kind on one side or both sides based on the center mark.
  • the above working length can be described.
  • the end mark may be displayed at one end or both ends based on the length direction.
  • the color of the mark may be any one selected from the group consisting of white, red, blue, yellow, green and a mixture of these colors, specifically white, black, red, yellow, yellow, yellow green, green, blue, It can be blue, blue, purple or reddish purple.
  • the center mark can be used to easily match the center of the orthodontic member and the wire, and the work mark can be used to easily find the working length from the center part. The end of the calibration member can be easily checked.
  • composition for the orthodontic member may further include a compound represented by the following formula (1).
  • n is any one of 1 to 8 integers.
  • Step (a) is a mixture of gelatin, glycerin, solbi solution and purified water to form a composition
  • the solvent of the sol beetle solution may be water.
  • the water-soluble or biodegradable substance is a compound represented by the following Chemical Formula 2.
  • R is independently a hydrogen atom, a deuterium atom, a C1 to C6 alkyl group, or a C1 to C6 hydroxyalkyl group, ⁇ is a repeating unit.
  • the number average molecular weight of the compound represented by Formula 2 This is 1,000 to 9,000,000.
  • C1 to C6 alkyl group is preferably -CH 3 and the number of days, C1 to C6
  • the hydroxyalkyl group can be preferably -CH 2 -CHOH-CH 3 .
  • the method may further comprise step (a-1) of maintaining the composition at a temperature of 50 to 100 ° C.
  • Step (a-1) is preferably 55 to 95 ° C. More preferably, it can be carried out at 60 to 90 ° C.
  • the components of the composition may be mixed evenly.
  • Step (a-1) can be carried out preferably for 2 to 6 hours, but can vary depending on the temperature of step (a-1). You can include additional steps.
  • the method may further include a step (a-2) of maintaining the composition at a temperature of 50 to 65 0 C.
  • Step (a-2) is preferably 53 to 53 ° C. It may be carried out at 62 ° C, more preferably at 54 to 60 ° C.
  • the wire is prepared, and the composition is coated on the surface of the wire to prepare a wire coated with the composition (step b).
  • the coating of step (b) may preferably vary depending on the gelation temperature of the composition.
  • the composition may be uniformly coated on the wire above the gelation temperature, and the gelation temperature.
  • the composition can be uniformly coated on the wire below the gelling temperature.
  • gelatin gels at low temperatures it is desirable to coat above the gelling temperature, since HPMC gels at higher temperatures. Coating at a temperature below the gelling temperature is preferred.
  • the orthodontic member may be tubular, vacuum polygonal, funnel, hollow cone pyramid or hollow polygonal pyramid.
  • the composition is dried on the wire coated with the composition to prepare an orthodontic member including the wire and the wire in the vacuum (step c).
  • step (c) is preferably performed at 25 to 30 ° C and a relative humidity of 20 to 40%.
  • Step (C) may be performed until the composition has reached equilibrium, and may be performed for 12 to 72 hours if performed under the above conditions.
  • step (c) the composition may be hardened into a gel close to a solid.
  • Orthodontic members are preferred to have a degree of strength that maintains the center of gravity and flexibility that does not break even when the orthodontic wire is bent so that it can be adapted to the tooth alignment when applied to the orthodontic procedure.
  • the orthodontic member is manufactured by removing the wire from the orthodontic member that couples the boosting wire (step d).
  • the method may further include processing oil on the surface of the orthodontic member (step d-1).
  • the oil may be mineral oil, silicone oil, vegetable oil, or the like.
  • a wire can be inserted into the orthodontic member so that the operator can easily perform the procedure.
  • gelatin 134 parts by weight of gelatin (Geltec, 250 bloom) were dispersed in 390 parts by weight of water, and then mixed with 140 parts by weight of glycerin. Next, the gelatin dissolution process was carried out for 60 minutes at 90 ° C., followed by degassing with 700 mmHg vacuum at 65 ° C. for 30 minutes. The defoaming solution was aged by aging at 60 ° C. for 6 hours. The solution was prepared.
  • a coating solution was prepared using salose (HPMC). After mixing 585 parts by weight of purified water and 1 part by weight of potassium sorbate, the solution was heated to 90 ° C. 220 parts by weight of HPMC and 194 parts by weight of ethanol were added to the 90 solution, which was then mixed for 2 hours to dissolve the HPMC. The prepared composition was aged for 55 to 12 hours to prepare a coating composition for orthodontic members.
  • HPMC salose
  • the coating solution prepared according to Example 1 is placed in a supporting liquid container maintained at 45 ° C.
  • Stainless steel straight wire with length of 100mm and 0.5mm diameter The wire was fixed with a set screw, and the wire was coated with paraffin.
  • the wire was immersed in the coating solution, immediately pulled out, and the coating solution was uniformly coated. Then, the phase was dried at a relative humidity of 25% for 24 hours, and then the wire was removed.
  • the orthodontic member was manufactured.
  • the coating solution prepared according to Example 2 was placed in a supporting liquid container kept at 20. Wires 100 mm long and 0.5 mm in diameter were fixed with a set screw, and the wires were coated with paraffin. The wires were immersed in a coating solution, immediately pulled out, and the coating solution was uniformly coated. Referring to FIGS. 3 and 4, After drying for 24 hours at a relative humidity of 25% at room temperature, an edible dye was used on the coating to display a white center mark, a work mark, and an end mark, and wires were removed to prepare an orthodontic member with a white mark.
  • Test Example 3 Manufacture of Wyred and Mixed Hachiochi Government Bond
  • the orthodontic member in which the center line is inserted into the orthodontic member having the center mark, the work mark, and the end mark of Test Example 2 is inserted, and the core line and the center mark coincide with each other. was prepared.
  • FIG. 7 The clinical test procedure of orthodontic calibration using the water-soluble tube prepared according to Test Examples 1 and 3 is shown in FIG. 7, and the front and side pictures are shown in FIG. 8.
  • nickel-titanium wire was inserted into the water-soluble tube prepared according to Test Example 1 in addition to oral cavity, and the tube into which the wire was inserted was directly adhered to the tooth. This appeared to be possible.
  • the water-soluble ribs prepared according to Test Example 1 were simple in structure and aesthetic, and there was no soft tissue stimulation caused by the device, so that the oral hygiene was easily maintained.
  • FIG. 9 The clinical test procedure of the orthodontic appliance applying the wire-bonded orthodontic member is shown in FIG. 9, and the front and side photographs of the orthodontic member applying the orthodontic member are shown in FIG.
  • the orthodontic member combined with the wire manufactured according to Test Example 4 was simple in structure and aesthetic, and there was no soft tissue stimulation by the device, so that it was easy to maintain oral hygiene.
  • FIG. 2 is a view of a conventional water-soluble valve-type orthodontic member using the composition of the present invention.
  • Fig. 11 schematically shows the side cross section of the bracket or the small hollow tube, and Fig. 11 shows the results of orthodontic calibration using conventional brackets.
  • brackets have a complex structure, which is not aesthetic, irritates oral hygiene and makes oral hygiene difficult.
  • FIG. 12 shows a photo of an orthodontic calibration using a conventional hollow tube type tube.
  • the wire was inserted in sequential order. As a result, it was found that it was only possible to apply a partial orthodontic treatment to the anterior part because it was essentially impossible to wire the wires from behind the neck.
  • the hollow tube type can be applied only to the partial orthodontic treatment limited to the anterior portion and that a lot of time is required for wire insertion.
  • a composition for water-soluble or biodegradable orthodontic members can be provided.
  • a water-soluble or biodegradable composition for use in an orthodontic member that is dissolved or biodegradable in the oral cavity and provides a playable wire can be provided.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

본 발명은 수용성 또는 생분해성 물질; 및 물을 포함하는 용제;를 포함하는 치열교정부재용 조성물이 제공한다. 이에 의하여 본 발명의 치열교정부재용 조성물 사용하여 제조된 수용성 또는 생분해성 치열교정부재의 중공에 와이어를 포함하는 치열교정복합체를 직접 치아에 부착함으로써 간편하게 치아 교정 시술이 가능하다.

Description

명세서
발명의명칭:치열교정부재에사용하기위한수용성또는생분해성 조성물
기술분야
[1] 본발명은수용성또는생분해성조성물에관한것으로서,보다상세하게는 치열교정부재에사용하기위한수용성또는생분해성조성물에관한것이다. 배경기술
[2] 치아의배열이가지런하지않거나위아래맞물림의상태가정상의위치를 벗어난상태를 "부정교합"이라하며이를바로잡아주는치료를교정치료라 한다.부정교합일경우에는보기에도좋지않을뿐만아니라발음이나 저작기능에도장애가유발되기때문에，부정교합인치아를잡아주기위한 다양한치열교정장치가사용되고있다.
[3] 그중가장대표적인치열교정장치는브라켓으로，교정용와이어와함께
사용하여치아를이동시킨다.기본적으로브라켓은비뚤어진치열형태대로 휘어진와이어에서생기는복원력을치아에전달하면서，치아가와이어를따라 미끄러져이동하도록가이드하는기능이있다.하지만브라켓은상대적으로 크고복잡한구조때문에매우불편하며,치료중에는브라켓.이보이기때문에 심미성이떨어진다ᅳ
[4] 이러한단점을보완하기위하여소형중공관형태의미니튜브와와이어를 이용한치열교정방법이사용되고있으며，이러한시술방법은
대한민국등록특허제 1,234,205호'치열교정치료용튜브 '에기재되어있다.
[5] 그러나미니튜브를이용한치열교정방법은다음과같은근본적문제점을 지니고있다.
[6] 첫째,불규칙하게비뚤어진치아에붙어있는 0.5mm보다작은내경을갖는 류브에와이어를끼우는것이매우어렵다.
[7] 둘째,목뒤에서부터와이어를끼우는것은불가능하기때문에미니류브는 구치부 (어금니)에사용할수없고，전치부 (앞니)의한정된부분의교정치료에만 사용할수있다.
[8] 따라서,환자의불편감은최소화하면서，간편하고보편적인치아교정시술이 가능한방법의개발이요구되는실정이다.
발명의상세한설명
기술적과제
[9] 본발명의목적은수용성또는생분해성치열교정부재용조성물을제공하는 것이다.
[10] 본발명의다른목적은구강내에서용해되거나생분해되어와이어가이동할 수있는유격을제공하는치열교정부재에사용하기위한수용성또는생분해성 조성물을제공하는것이다.
과제해결수단
[11] 본발명의일측면에따르면,수용성또는생분해성물질;및물을포함하는
용제;를포함하는치열교정부재용조성물이제공된다
[12] 또한상기치열교정부재용조성물이수용성또는생분해성물질 10내지
100중량부;및용제 20내지 990증량부；를포함할수있다.
[13] 또한상기수용성또는생분해성물질이젤라틴，전분，전분유도체，샐를로오스， 샐를로오스유도체,식물성검,아가，알긴，알긴산염，카라기난,키토산, 키토산유도체,펙틴,덱스트란，히알루로닉에시드，폴리아크릴아미드， 폴리비닐피를리돈，폴리비닐알코올，폴리아크릴릭에시드，폴리에틸렌글라이콜， 폴리프로필렌글라이콜,폴리에틸렌옥사이드,폴리프로필렌옥사이드，생분해성 폴리아마이드,생분해성폴리우레탄및생분해성폴리에스터중에서선택된 1종 이상을포함할수있다.
[14] 또한상기수용성또는생분해성물질이상기젤라틴，전분，전분유도체,
샐를로오스，셀를로오스유도체，식물성검,아가，알긴，알긴산염，카라기난, 키토산，키토산유도체，펙틴,덱스트란，히알루로닉에시드，폴리아크릴아미드， 폴리비닐피롤리돈，폴리비닐알코올，폴리아크릴릭에시드,폴리에틸렌글라이콜， 폴리프로필렌글라이콜，폴리에틸렌옥사이드,폴리프로필렌옥사이드，생분해성 폴리아미드,생분해성폴리우레탄및생분해성폴리에스터중에서선택된 1종 이상 100중량부에대하여,아래화학식 1로표시되는화합물 1내지 200중량부를 추가로포함할수있다.
[15] [화학식 1]
Figure imgf000004_0001
[17] 상기화학식 1에서 n은 1내지 8의정수중어느하나이다.
[18] 또한상기수용성또는생분해성물질이아래화학식 2로표시되는화합물을 포함할수있다.
[19] [화학식 2] [2이
Figure imgf000005_0001
[21] 상기화학식 2에서 R은각각독립적으로수소원자,중수소원자, C1내지 C6 알킬기또는, C1내지 C6히드록시알킬기이고 , η은반복단위이고.상기화학식 2로표시되는화합물의수평균분자량이 1,000내지 9,000,000이다.
[22] 또한상기화학식 2로표시되는화합물이히드록시프로필메틸샐를로오스일 수있다.
[23] 또한상기히드록시프로필메틸셀를로오스는메톡시기의치환도가 15내지 30%이고，히드록시프로폭시의치환도가 4내지 32%일수있다.
[24] 또한상기히드록시프로필메틸셀를로오스가 20°C의온도와 2중량 %수용액 농도에서점도가 1내지 35mPa.s일수있다.
[25] 또한상기용제가선형또는분쇄형의 C2내지 C9의알코올을추가로포함할 수있다.
[26] 또한상기치열교정부재용조성물이소르빈산염，살리신산염및벤조산염 증에서선택된 1종이상의안정제를추가로포함할수있다.
[27] 또한상기치열교정부재용조성물이색소를추가로포함할수있다.
[28] 또한상기치열교정부재가튜브 (tube)형，중공다각기등형，중공다각뿔대형， 증공원뿔대형또는깔때기 (funnel)형의치열교정부재이고，상기
치열교정부재는상기수용성또는생분해성물질을포함할수있다.
[29] 또한상기치열교정부재가중공에와이어를포함할수있다.
발명의효과
[30] 본발명에따르면수용성또는생분해성치열교정부재용조성물을제공할수 있다.
[31] · 본발명에따르면구강내에서용해되거나생분해되어와이어가이동할수 있는유격을제공하는치열교정부재에사용하기위한수용성또는생분해성 조성물을제공할수있다.
도면의간단한설명
[32] 도 1은본발명의일실시예에따른조성물을이용한치열교정부재의형태중 튜브형과사각기둥형을묘사한개략도이다.
[33] 도 2는본발명의일실시예에따른조성물을이용한수용성또는생분해성 튜브형치껼교정부재,종래의브라켓또는종래의소형금속중공관을적용한후 치아의측단면을개략적으로나타낸것이다.
[34] 도 3은본발명의일실시예에따른조성물을이용한마크가표시된
치열교정부재의개략도이다.
[35] 도 4는본발명의일실시예에따른조성물을이용한와이어를결합한
치열교정부재의개략도이다.
[36] 도 5는본발명의일실시예에따른조성물을이용한마크가표시된
치열교정부재의사진이다.
[37] 도 6은본발명의일실시예에따른조성물을이용한마크가표시된
치열교정부재와와이어를결합한치열교정부재의사진이다.
[38] 도 7은본발명의실시예 3의조성물을이용한수용성튜브형치열교정부재를 이용한치열교정의임상시험 ^정을나타낸것이다.
[39] 도 8은본발명의실시예 3에 른조성물을이용한수용성튜브형
치열교정부재를이용한임상시험결과의정면과측면사진을나타낸것이다.
[4이 도 9는본발명의실시예 4의조성물을이용한수용성튜브형치열교정부재를 이용한치열교정의임상시험과정을나타낸것이다.
[41] 도 10은본발명의실시예 4에따른조성물을이용한수용성류브형
치열교정부재를이용한임상시험결과의정면과측면사진을나타낸것이다.
[42] 도 11는종래의브라켓을이용한치열교정의결과를나타낸것이다.
[43] 도 12은종래의중공관형태의금속류브를이용한치열교정의사진을나타낸 것이다.
발명의실시를위한최선의형태
[44] 이하,본발명이속하는기술분야에서통상의지식을가진자가용이하게
실시할수있도록첨부된도면을참조하여본발명의실시예를상세히
설명하도록한다.
[45] 그러나,이하의설명은본발명을특정한실시형태에대해한정하려는것이 아니며，본발명을설명함에있어서관련된공지기술에대한구체적인설명이 본발명의요지를흐릴수있다고판단되는경우그상세한설명을생략한다.
[46] 본원에서사용한용어는단지특정한실시예를설명하기위해사용된것으로, 본발명을한정하려는의도가아니다.단수의표현은문맥상명백하게다르게 뜻하지않는한，복수의표현을포함한다.본출원에서， "포함하다"또는 "가지다" 등의용어는명세서상에기재된특징 ,숫자，단계，동작，구성요소，또는이들을 조합한것이존재함을지정하려는것이지，하나또는그이상의다른특징들이나 숫자，단계,동작,구성요소，또는이들을조합한것들의존재또는부가가능성을 미리배제하지않는것으로이해되어야한다.
[47]
[48] 이하,본발명의치열교정부재용조성물에대해설명하도록한다.
[49] 본발명의치열교정부재용조성물은수용성또는생분해성물질;및물을 포함하는용제 ;를포함할수있다.또한,상기치열교정부재용코팅조성물은 치열교정용와이어에코팅하는데사용하거나중공을갖는치열교정부재를 제조하는데사용할수있다.
[50] 바람직하게는,상기치열교정부재용조성물은수용성또는생분해성물질 10 내지 100중량부;및물을포함하는용제 20내지 990중량부；를포함할수있다/
[51]
[52] 상기수용성또는생분해성물질은구강내에서분해될수있는물질이라면 어느것이든가능할수있다.바람직하게는상기수용성또는생분해성물질이 젤라틴，전분,전분유도체，샐를로오스,셀를로오스유도체，식물성검,아가， 알긴,알긴산염，카라기난,키토산，키토산유도체，펙틴,텍스트란，
히알루로닉에시드,폴리아크릴아미드，폴리비닐피롤리돈,폴리비닐알코올， 폴리아크릴릭에시드,폴리에틸렌글라이콜，폴리프로필렌글라이콜,
폴리에틸렌옥사이드，폴리프로필렌옥사이드,생분해성폴리아마이드，생분해성 폴리우레탄및생분해성폴리에스터중에서선택된 1종이상일수있다.
[53] 상기생분해성폴리아미드는폴리락틱산，변성폴리락틱산일수있다.
[54] 또한상기수용성또는생분해성물질이상기젤라틴，전분,전분유도체，
셀를로오스，셀를로오스유도체,식물성검 ,아가，알긴，알긴산염,카라기난， 키토산，키토산유도체，펙틴,덱스트란,히알루로닉에시드，폴리아크릴아미드, 폴리비닐피롤리돈，폴리비닐알코을，폴리아크릴릭에시드,폴리에틸렌글라이콜， 폴리프로필렌글라이콜，폴리에틸렌옥사이드,폴리프로필렌옥사이드，생분해성 폴리아미드，생분해성폴리우레탄및생분해성폴리에스터중에서선택된 1종 이상 100중량부에대하여,아래화학식 1로표시되는화합물 1내지 200중량부를 추가로포함할수있다.
[55] [화학식 1]
Figure imgf000007_0001
[57] 상기화학식 1에서 n은 1내지 8의정수중어느하나이다.
[58]
[59] 상기화학식 1로표시되는화합물은바람직하게는솔비롤및글리세린일수 있다. [60] 상기수용성또는생분해성물질은더욱바람직하게는젤라틴 100중량부에 대하여，글리세린 5내지 100증량부및솔비를 1내지 100중량부를포함할수 있다.
[61] 또한,상기수용성또는생분해성물질은정제수 1내지 250중량부를추가로 포함할수있다ᅳ
[62] 상기젤라틴은젤리강도는 30내지 500 Bloom일수있고,바람직하게는 100 내지 400 Bloom일수있다.
[63] 상기젤리강도란젤라틴의대표적인물리적특성이다.블룸값 (Bloom Value)은 젤라틴의강도를표시하는데사용되며，.젤리강도 (Jelly strength)는 BS기준 (British Standard: BS 757)에따라 6.67%의젤라틴용액을젤리강도계의
플런저 (Plunger)가표면으로부터 4mm깊이로눌렀을때필요한힘 (Force)으로 정의할수있다.
[64]
[65] 또한상기수용성또는생분해성물질이아래화학식 2로표시되는
화합물인샐루로오스유도체를포함할수있다.
[66] [화학식 2]
Figure imgf000008_0001
[68] 상기화학식 2에서 R은각각독립적으로수소원자,중수소원자， C1내지 C6 알킬기또는， C1내지 C6히드록시알킬기이고， n은반복단위이고.상기화학식
2로표시되는화합물의수평균분자량이 1,000내지 9,000,000이다.
[69] 상기폴리에틸렌글라이콜은중량평균분자량이 1,000내지 100,000인고체상인 것이바람직하다.
[70] 상기수용성또는생분해성고분자는변성전분및식물성검등올포함할수 있다.
[71] 상기화학식 2로표시되는화합물이히드록시프로필메틸샐를로오스일수 있다.
[72] 상기히드록시프로필메틸샐를로오스는메톡시기의치환도가 15내지
30%이고，히드록시프로폭시의치환도가 4내지 32%일수있다.
[73] 상기히드록시프로필메틸샐를로오스가 20°C의온도와 2증량 %수용액
농도에서점도가 1내지 35mPa.s일수있다. [74] 상기용제가선형또는분쇄형의 C2내지 C9의알코올을추가로포함할수 있다.여기서용제에포함되는물과알코올의증량비는 100:0내지 5:95일수 있다.
[75] 상기치열교정부재용조성물이소르빈산염，살리신산염및벤조산염중에서 선택된 1종이상의안정제를추가로포함할수있다.
[76] 상기안정제의함량은수용성또는생분해성물질 100중량부에대하여으 01 내지 5중량부포함할수있다.안정제의함량이 0.01미만인때에는보존효과를 보이지않고, 5중량부를초과하면제조된치열교정부재의기계적물성을 저하시켜바람지하지않다.
[77] 상기치열교정부재용조성물이색소를추가로포함할수있다.
[78] 상기색소는천연식용색소,타르계식용색소，베타카로틴,황산구리，
산화제이철,캐러멜，구리,철클로로필린나트륨또는산화티타늄일수있다.
[79] 상기치열교정용코팅조성물은계면활성제 0.1내지 5중량부를추가로포함할 수있다.
[8이 상기계면활성제는폴리에틸렌글리콜，폴리소르베이트,지방산
모노글리세린에스테르,지방산폴리글리콜에스테르,지방산소르비탄에스테르, 지방산자당에스테르,지방산알칸올아미드,폴리에틸렌글리콜축합형비이온 계면활성제일수있다.
[81] 상기폴리에틸렌글라이콜은분자량이 1,000내지 100,000인고체상일수있다.
[82]
[83] 도 1은본발명의일실시예에따른조성물을이용한류브형치열교정부재의 개략도이다.
[84] 이하，도 1을참조하여본발명의조성물을이용한치열교정부재에대해
설명하도록한다.
[85] 본발명의조성물을이용한치열교정부재는류브 (tube)형,중공다각기둥형, 중공다각뿔대형，중공원뿔대형또는깔때기 (funnel)형이고ᅳ수용성또는 생분해성물질을포함한다.
[86] 상기튜브형치열교정부재는내경은 0.2내지 1.0 mm이고，두께는 0.001내지 0.5 mm인것이바람직하다.
[87] 또한,상기중공다각기등형치열교정부재의단면은중공의다각형이고,상기 중공의다각형에내접하는원의직경은 0.2내지 1.0 mm이다.또한,상기중공 다각기등형치열교정부재의두께는 0.001내지 0.5 mm인것이바람직하다ᅳ 그러나，상기내경및직경은치열교정부재의증공에삽입될와이어의직경에 따라달라질수있다.
[88] 상기중공다각기둥형은 n각다각기둥형이고， n은 3내지 20의정수증어느 하나일수있고，바람직하게는 4내지 15，더욱바람직하게는 4내지 8의정수중 어느하나일수있고，보다더욱바람직하게는 4인중공 4각기둥형일수있다.
[89] 상기중공원뿔대형치열교정부재의최대내주의직경 (E)대비최소내주의 직경 (e)의비 (E/e, q)는 Kq<10일수있고,바람직하게는 2<q<5,더욱
바람직하게는 3≤q≤4일수있다.
[90] 상기중공다각뿔대형치열교정부재의단면은중공의다각형이고，상기중공의 다각형에외접하는원의최대직경 (F)대비최소직경 (f)의비 (F/f, p)가 1<ρ≤10일 수있고,바람직하게는 2≤p≤5,더욱바람직하게는 3≤p≤4일수있다.
[91] 상기중공다각뿔대형의중공은 n각뿔대형이고 , η은 3내지 20의정수중어느 하나일수있고,바람직하게는 4내지 15，더욱바람직하게는 4내지 8의정수중 어느하나일수있다.
[92] 상기깔때기형의치열교정부재는중공형원기둥의일단부에결합된중공형 원뿔대를포함하는형태이고，상기중공형원뿔대의최대내주의직경 (D)대비 상기중공형원기등의내주의직경 (d)의비 (D/d, r)는 l<r≤10일수있다.상기 비는바람직하게는 2≤r≤5,더욱바람직하게는 3≤r≤4일수있다.또한,상기 깔대기형의치열교정부재는증공형다각기등의일단부에결합된중공형 다각뿔대를포함하는형태일수있고，상기중공형다각뿔대의단면인중공의 다각형에외접하는원의최대직경 (C).대비최소직경 (c)의비 (C/c, s)가 l<s≤10 일수있고，바람직하게는 2≤s≤5,더욱바람직하게는 3≤s≤4일수있다.
[93] 도 4및도 6을참고하면，상기치열교정부재 (10)의중공에치열교정용
와이어 (30)을포함하는치열교정복합체 (20)를상기치열교정부재 (10)에 와이어 (30)를삽입하여제조하고,상기부재가감싸고있는와이어를비뚤어진 치열에레진을이용하여치아에접착한다.비뚤어진치열형태대로휘어서 접착된와이어에서는복원력이발생하고，이는접착제인레진을매개체로 치아를이동시킬수있는교정력으로치아에전달된다.이와동시에
치열교정부재는수용성또는생분해성으로구강내에서녹기때문에와이어와 레진사이에는간극이형성되어,치아는와이어를따라미끄러지면서이동할수 있다.
[94] 또한상기치열교정부재는작업상편의를위하여색상을투명하게하거나또는 백색,적색，청색，황색，녹색및이들의혼합색으로제조할수있고,구체적으로 투명하거나백색，검은색，적색，황적색,황색，황록색，녹색,청록색,청색， 청자색，보라색또는적자색을제조할수있다.
[95] 또한도 3및도 5를참고하면,상기치열교정부재 (10)는작업상편의를위하여 마크 (100,200,300)를표시할수있다.
[96] 또한상기치열교정부재 (10)의길이방향을기준으로중심부를표시하는
중심마크 (100)，상기증심부로부터의거리를표시하는작업마크 (200)，또는 끝단을표시하는끝단마크 (300)일수있다.
[97] 또한상기중심마크가상기치열교정부재의내경또는외경의크기에따라 소정의색상으로표시될수있다.
[98] 또한상기증심마크는두께가 0.1내지 5mm일수있다.
[99] 또한상기작업마크를상기중심마크를기준으로일측면또는양측면에 1종 이상의작업길이를기재할수있다.
[100] 또한상기끝단마크를길이방향을기준으로일말단또는양말단에표시할수 있다.
[101] 또한상기마크의색상은백색，적색,청색，황색,녹색및이들의혼합색으로 이루어진군에서선택된어느하나일수있고，구체적으로백색，검은색，적색， 황적색，황색，황록색，녹색，청록색,청색，청자색，보라색또는적자색일수있다. 마크가표시된치열교정부재를사용할경우상기중심마크를이용하여 치열교정부재의증심과와이어의중심을쉽게일치시킬수있고，작업마크를 이용하여용이하게중심부로부터의작업길이를알수있으며，끝단마크를 이용하여치열교정용부재의말단을쉽게확인할수있다.
[102]
[103] 이하,본발명의조성물을이용한치열교정부재의제조방법에대해설명하도록 한다.
[104] 먼저 ?수용성또는생분해성물질및정제수를흔합하여치열교정부재용
조성물을제조한다 (단계 a).
[105] 여기서치열교정부재용조성물은하기화학식 1로표시되는화합물을추가로 포함할수있다.
[106] [화학식 1]
[107]
Figure imgf000011_0001
[108] 상기화학식 1에서
[109] n은 1내지 8의정수중어느하나이다.
[110] 단계 (a)는젤라틴，글리세린，솔비를용액및정제수를흔합하여조성물을
제조하는단계를포함할수있다.상기솔비틀용액의용매는물일수있다.
[111] 여기서수용성또는생.분해성물질은아래화학식 2로표시되는화합물일
수있다.
[112] [화학식 2]
Figure imgf000012_0001
[1 14] 상기화학식 2에서 R은각각독립적으로수소원자,중수소원자, C1내지 C6 알킬기또는， C1내지 C6히드록시알킬기이고， η은반복단위이고.상기화학식 2로표시되는화합물의수평균분자량이 1,000내지 9,000,000이다.
[115] 여기서 C1내지 C6알킬기는바람직하게는 -CH3일수있고, C1내지 C6
히드록시알킬기는바람직하게는 -CH2-CHOH-CH3일수있다.
[116] 단계 (a)이후에조성물을 50내지 100°C의온도로유지하는단계 (a-1)을추가로 포함할수있다.단계 (a-1)은바람직하게는 55내지 95°C,더욱바람직하게는 60 내지 90°C에서수행될수있다.
[117] 상기온도범위에서상기조성물의성분들이고르게섞일수있다.
[1 18] 단계 (a-1)은바람직하게는 2내지 6시간동안수행될수있으나단계 (a-1)의 온도에따라달라질수있디-.또한，단계 (a-1)은진공하에서탈포하는단계를 추가로포함할수있다.
[119] 상기단계 (a-1)이후에상기조성물을 50내지 650C의온도로유지하는단계 (a-2)를추가로포함할수있다.단계 (a-2)는바람직하게는 53내지 62°C,더욱 바람직하게는 54내지 60°C에서수행될수있다.
[12이 다음으로，와이어를준비하고，상기와이어의표면에상기조성물을코팅하여 조성물이코팅된와이어를제조한다 (단계 b).
[121] 상기단계 (b)의코팅은바람직하게는상기조성물의겔화온도에따라달라질 수있다.겔화온도가낮은물질의경우상기조성물은겔화온도이상에서상기 와이어에균일하게코팅될수있으며，겔화온도가높은물질의경우상기 조성물은겔화온도이하에서상기와이어에균일하게코팅될수있다.예를 들어젤라틴은낮은온도에서겔화되므로겔화온도이상에서코팅을하는것이 바람직하고, HPMC는높은온도에서겔화되기때문에겔화온도보다낮은 온도에서코팅하는것이바람직하다.
[122] 상기치열교정부재는튜브형，증공다각기등형，깔때기형，중공원뿔대형또는 중공다각뿔대형일수있다.
[123] 다음으로，상기조성물로코팅된와이어에서상기조성물을건조시켜，상기 와이어및상기와이어를증공에포함하는치열교정부재를제조한다 (단계 c).
[124] 상기단계 (c)는바람직하게는 25내지 30°C,상대습도 20내지 40%에서수행될 수있으나이에한정되는것은아니다.단계 (C)는상기조성물이평형상태에 도달할때까지수행할수있으며，상기조건에서수행될경우 12내지 72시간 동안수행될수있다ᅳ
[125] 단계 (c)에서상기조성물은고체에가까운겔 (gel)로굳어질수있다.상기
치열교정부재는치아교정시술에적용하였을때치아의배열상태에적합할수 있도록교정용와이어의구부러짐에도파손되지않는유연성을가지면서 중苦을유지하는정도의강도를갖는것이바람직하다.
[126] 마지막으로，상기증공에와이어를결합한치열교정부재로부터상기와이어를 제거하여치열교정부재를제조한다 (단계 d).
[127] 단계 d이후에，상기치열교정부재의표면에오일을처리하는단계를추가로 포함할수있다 (단계 d-1).
[128] 상기오일은미네랄오일，실리콘오일,식물성오일등이가능하다.
[129] 한편，시술자가시술을용이하게수행하기위하여치열교정부재에와이어를 삽입하여제공할수있다.
[130]
발명의실시를위한형태
[131] [실시예]
[132] 이하，본발명의바람직한실시예를들어설명하도록한다.그러나이는예시를 위한것으로서이에의하여본발명의범위가한정되는것은아니다.
[133] 심시예 1:코팅 ^액의제조
[134] 430중량부의젤라틴 (젤텍사, 250 bloom)을 390중량부의물에분산시킨후, 140 중량부의글리세린을넣고혼합하였다.이후물에용해시킨솔비톨용액 (70% 농도) 5증량부를넣고고르게분산시켰다.다음으로, 60분간ᅳ 90°C에서젤라틴 용해과정올거친후 30분동안 65°C에서 700mmHg진공으로탈포하였다.상기 탈포된용액을 60°C에서 6시간동안에이징 (aging)시켜코팅용액을제조하였다.
[135] 심시예 2:코팅용액의제조
[136] 2중량 %수용액의점도가 6 mPa.s인하이드록시프로필메틸
샐를로오스 (HPMC)를이용하여코팅용액을제조하였다.정제수 585중량부와 소르빈산칼륨 1중량부를넣어혼합한후，용액의온도를 90까지가열시켰다. 90의용액에 HPMC 220중량부와에탄올 194증량부를투입하여 2시간동안 흔합하여 HPMC를용해시켰다.상기제조된조성물을 55에서 12시간동안 숙성시켜치열교정부재용코팅조성물을제조하였다.
[137]
[138] [시험예]
[139] 시험예 1:수용성튜브의 제조
[140] 실시예 1에따라제조된코팅용액을 45°C로유지되어있는담지액통에넣는다. 길이 lOOmm, 0.5mm직경의스테인리스강 (stainless steel)직선형와이어를 고정나사로고정하고，상기와이어를파라핀으로코팅하였다.상기와이어를 코팅용액에담지한후바로빼내어코팅용액을균일하게코팅하였다.이후, 상은에서상대습도 25%, 24시간동안건조한후상기와이어를제거하여 치열교정부재를제조하였다.
[141] 시험예 2:수용성튜브의제조
[142] 실시예 2에따라제조된코팅용액을 20로유지되어있는담지액통에넣었다. 길이 100mm, 0.5mm직경의와이어를고정나사로고정하고，상기와이어를 파라핀으로코팅하였다.상기와이어를코팅용액에담지한후바로빼내어 코팅용액을균일하게코팅하였다.도 3과 4를참조하면,이후,상온에서 상대습도 25%, 24시간동안건조한후코팅부에식용색소를사용하여백색의 중심마크,작업마크및끝단마크를표시하고와이어를제거하여백색마크가 표시된치열교정부재를제조하였다.
[143]
[144] 시험예 3:와이어름겸합하치염교정부채의제조
[145] 시험예 1의치열교정부재에와이어를삽입하여와이어를결합한
치열교정부재를제조하였다.
[146] 시험예 4:와이어름겸합하치염교정부재의제조
[147] 도 5와도 6을참조하면,시험예 2의중심마크,작업마크및끝단마크가표시된 치열교정부재에중심선이표시된와이어를삽입하고증심선과중심마크를 일치시켜와이어를결합한치열교정부재를제조하였다.
[148]
[149] 상시 예 1:치염교정부재를이용하치염교정
[150] 시험예 1및 3에따라제조된수용성튜브를이용한치열교정의임상시험 과정을도 7에나타내었고,정면과측면사진을도 8에나타내었다.
[151] 도 7및도 8을참조하면,시험예 1에따라제조된수용성튜브에구강외에서 니켈-티타늄와이어를삽입하고，와이어가삽입된튜브를직접치아에 접착하였다.그결과,구치부에서도웅용이가능한것으로나타났다.
[152] 따라서，시험예 1에따라제조된수용성류브는단순한구조로심미적이며, 장치에의한연조직자극이없어편안하고,쉽게구강위생을유지할수있는 것을알수있었다.
[153]
[154] 상시 예 2:치염교 부재름이용하치염교
[155] 시험예 2및 4에따라치열교정부재의중공에와이어를관통시켜결합한
와이어를결합한치열교정부재를적용한치열교정의임상시험과정을도 9에 나타냈고，치열교정부재를적용한치열의정면과측면사진을도 10에나타냈고， 나타내었다.
[156] 도 9및 10을참조하면，시험예 1및 3에따라제조된치열교정부재를직접
치아에접착하였다.그결과，구치부에서도웅용이가능한것으로나타났다. [157] 따라서,시험예 4에따라제조된와이어와결합된치열교정부재는단순한 구조로심미적이며,장치에의한연조직자극이없어편안하며，쉽게구강위생을 유지할수있음을알수있었다.
[158]
[159] ¾상비교시험예 1：종래의브라 ᅵ음이용하치염교정
[160] 도 2는본발명의조성물을이용한수용성류브형치열교정부재와종래의
브라켓또는소형중공관의측단면을개략적으로나타낸것이고,도 11은종래의 브라켓을이용한치열교정의결과를나타낸것이다.
[161] 도 2및도 11을참조하면,종래의브라켓을치아에접착한후결속타이를
이용하여와이어가브라켓에서빠지지않도록결속하였다.그결과,크고복잡한 구조를지닌브라켓과그부속물은구강내연조직을자극하는것으로나타났다.
[162] 따라서，종래의브라켓은복잡한구조로심미적이지않고,구강내연조직을 자극하며구강위생유지를어렵게하는것을알수있었다.
[163]
[164] 임상비교시험예 2:중공과형태의튜브름이용하치염교정
[165] 종래의중공관형태의튜브를이용한치열교정의사진을도 12에나타내었다.
[166] 도 2및도 12를참조하면，종래의중공관형태의류브를치아에접착한후
와이어를순차적으로통과하도록삽입하였다.그결과，목뒤에서부터와이:,어를 끼우는것은근본적으로불가능하기때문에，전치부에한정된부분교정 치료에만웅용할수있는것으로나타났다.
[167] 따라서，중공관형태의튜브는전치부에한정된부분교정치료에만적용할수 있고，와이어삽입에많은시간이소요되는것을알수있었다.
[168]
[169] 본발명의범위는상기상세한설명보다는후술하는특허청구범위에의하여 나타내어지며，특허청구범위의의미및범위그리고그균등개념으로부터 도출되는모든변경또는변형된형태가본발명의범위에포함되는것으로 해석되어야한다.
[Π0]
산업상이용가능성
[171] 본발명에따르면수용성또는생분해성치열교정부재용조성물을제공할수 있다.
[172] 본발명에따르면구강내에서용해되거나생분해되어와이어가이동할수 있는유격을제공하는치열교정부재에사용하기위한수용성또는생분해성 조성물을제공할수있다.

Claims

청구범위
[청구항 1] 수용성또는생분해성물질;및
물을포함하는용제;를
포함하는치열교정부재용조성물.
[청구항 2] 제 1항에있어서，
상기치열교정부재용조성물이
수용성또는생분해성물질 10내지 100중량부;및
용제 20내지 990중량부；를포함하는것을특징으로하는치열교정부재용 조성물.
[청구항 3] 제 1항에있어서，상기수용성또는생분해성물질이
젤라틴，전분,전분유도체,셀를로오스，셀를로오스유도체,식물성검, 아가，알긴,알긴산염，카라기난,키토산,키토산유도체,펙틴，텍스트란, 히알루로닉에시드,폴리아크릴아미드,폴리비닐피롤리돈， 폴리비닐알코올，폴리아크릴릭에시드,폴리에틸렌글라이콜， 폴리프로필렌글라이콜,폴리에틸렌옥사이드，폴리프로필렌옥사이드, 생분해성폴리아마이드,생분해성폴리우레탄및생분해성폴리에스터 중에서선택된 1종이상을포함하는것을특징으로하는치열교정부재용 조성물.
[청구항 4] 제 3항에있어서,상기수용성또는생분해성물질이
상기젤라틴,전분,전분유도체,샐를로오스，샐를로오스유도체,식물성 검 ,아가，알긴 알긴산염 ,카라기난,키토산,키토산유도체，펙틴， 덱스트란，히알루로닉에시드,폴리아크릴아미드,폴리비닐피를리돈, 폴리비닐알코올,폴리아크릴릭에시드，폴리에틸렌글라이콜， 폴리프로필렌글라이콜，폴리에틸렌옥사이드,폴리프로필렌옥사이드, 생분해성폴리아미드,생분해성폴리우레탄및생분해성폴리에스터 중에서선택된 1종이상 100중량부에대하여,아래화학식 1로표시되는 화합물 1내지 200증량부를추가로포함하는것을특징으로하는 치열교정부재용조성물.
[화학식 1]
Figure imgf000017_0001
상기화학식 1에서
n은 1내지 8의정수중어느하나이다.
[청구항 5] 제 3항에있어서,
상기수용성또는생분해성물질이아래화학식 2로표시되는화합물을 포함하는것을특징으로하는치열교정부재용조성물.
[
Figure imgf000017_0002
상기화학식 2에서
R은각각독립적으로수소원자,중수소원자， C1내지 C6알킬기또는， C1 내지 C6히드록시알킬기이고，
n은반복단위이고.
상기화학식 2로표시되는화합물의수평균분자량이 1,000내지
9,000,000이다.
[청구항 6] 제 5항에있어서,
상기화학식 2로표시되는화합물이히드록시프로필메틸샐를로오스인 것을특징으로하는치열교정부재용조성물.
[청구항 7] 겨 16항에있어서，
상기히드록시프로필메틸셀를로오스는메록시기의치환도가 15내지 30%이고,히드록시프로폭시의치환도가 4내지 32%인것을특징으로 하는치열교정부재용조성물.
[청구항 8] 제 7항에있어서，
상기히드록시프로필메틸셀를로오스가 20oC의온도와 2중량 %수용액 농도에서점도가 1내지 35mPa.s인것을특징으로하는치열교정부재용 조성물.
[청구항 9] 제 1항에있어서，
상기용제가선형또는분쇄형의 C2내지 C9의알코올을추가로포함하는 것을특징으로하는치열교정부재용조성물,
[청구항 10] 제 9항에있어서,
상기치열교정부재용조성물이소르빈산염,살리신산염및벤조산염 증에서선택된 1종이상의안정제를추가로포함하는것을특징으로하는 치열교정부재용조성물.
[청구항 11] 제 10항에있어서,
상기치열교정부재용조성물이색소를추가로포함하는것을특징으로 하는치열교정부재용조성물.
[청구항 12] 제 1항에있어서，상기치열교정부재가
튜브 (tube)형,중공다각기등형，증공다각뿔대형,중공원뿔대형또는 깔때기 (funnel)형의치열교정부재이고,
상기치열교정부재는상기수용성또는생분해성물질을포함하는것을 특징으로하는치열교정부재용조성물.
[청구항 13] 제 12항에있어서，
상기치열교정부재가중공에와이어를포함하는것을특징으로하는 치열교정부재용조성물.
PCT/KR2016/005054 2015-07-16 2016-05-13 치열교정부재에 사용하기 위한 수용성 또는 생분해성 조성물 WO2017010667A1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2015-0100987 2015-07-16
KR1020150100987A KR101591015B1 (ko) 2015-07-16 2015-07-16 치열교정용 코팅 조성물 및 그의 제조 방법
KR20150181574 2015-12-18
KR10-2015-0181574 2015-12-18

Publications (1)

Publication Number Publication Date
WO2017010667A1 true WO2017010667A1 (ko) 2017-01-19

Family

ID=57757813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/005054 WO2017010667A1 (ko) 2015-07-16 2016-05-13 치열교정부재에 사용하기 위한 수용성 또는 생분해성 조성물

Country Status (1)

Country Link
WO (1) WO2017010667A1 (ko)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003335A (ja) * 2000-04-21 2002-01-09 Koden Kk 化粧用コーティング組成物、除去剤、および口内用開唇支持体
US20120199138A1 (en) * 2011-02-08 2012-08-09 Hannapel Eric D Orthodontic appliance shield
US20140212827A1 (en) * 2011-08-24 2014-07-31 Tsi-Zong Tzou Orthodontic appliances with dissolvable coatings
US20140302448A1 (en) * 2013-04-05 2014-10-09 Benjamin Cassalia Orthodontic Wire Alignment System and Method
KR20140138937A (ko) * 2012-03-23 2014-12-04 호아킨 티. 아리자 치열 교정용 튜브
KR101591015B1 (ko) * 2015-07-16 2016-02-03 (주) 베리콤 치열교정용 코팅 조성물 및 그의 제조 방법

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003335A (ja) * 2000-04-21 2002-01-09 Koden Kk 化粧用コーティング組成物、除去剤、および口内用開唇支持体
US20120199138A1 (en) * 2011-02-08 2012-08-09 Hannapel Eric D Orthodontic appliance shield
US20140212827A1 (en) * 2011-08-24 2014-07-31 Tsi-Zong Tzou Orthodontic appliances with dissolvable coatings
KR20140138937A (ko) * 2012-03-23 2014-12-04 호아킨 티. 아리자 치열 교정용 튜브
US20140302448A1 (en) * 2013-04-05 2014-10-09 Benjamin Cassalia Orthodontic Wire Alignment System and Method
KR101591015B1 (ko) * 2015-07-16 2016-02-03 (주) 베리콤 치열교정용 코팅 조성물 및 그의 제조 방법

Similar Documents

Publication Publication Date Title
DE69918703T2 (de) Filmbildende zusammensetzungen aus modifizierter stärke
JP5372761B2 (ja) ヒドロキシプロピルメチルセルロース硬カプセルおよび製造方法
WO2017010668A1 (ko) 치열교정복합체 및 그의 제조방법
US8753613B2 (en) Dental retraction material having enhanced fluid absorption
ES2566533T3 (es) Composiciones adhesivas para dentadura postiza
FR2978047A1 (fr) Nouvelle composition hemostatique
JP5489471B2 (ja) Ｐｅｇ充填硬質カプセル剤のバンドシール
JP2005137935A (ja) 硬質カプセル及びその製造方法
WO2017010669A1 (ko) 치열교정부재 및 그의 제조방법
KR101591015B1 (ko) 치열교정용 코팅 조성물 및 그의 제조 방법
WO2017010667A1 (ko) 치열교정부재에 사용하기 위한 수용성 또는 생분해성 조성물
KR101695842B1 (ko) 마크가 표시된 치열교정부재 및 그의 제조방법
KR101591011B1 (ko) 치열교정용 부재 및 그의 제조방법
EP2525770A1 (fr) Materiau d&#39;insertion destine a elargir le sillon gingival
US20120161067A1 (en) Dental etching gel composition and method of use thereof
JP4994897B2 (ja) 歯科用前処理剤組成物
KR102146273B1 (ko) 치열교정용 와이어 복합체 및 그의 제조방법
KR20170009680A (ko) 치열교정용 부재 및 그의 제조방법
JP2650060B2 (ja) 義歯床過圧部診査用ペースト
JP5225723B2 (ja) 義歯安定剤
KR20170009682A (ko) 치열교정용 코팅 조성물 및 그의 제조 방법
JP2002173409A (ja) 歯科用根管充填材組成物
JP4425374B2 (ja) 根管充填用シーラー組成物
Brandt et al. Microleakage of Fissure Sealants after Aging Based on Fissure Configuration

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16824584

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16824584

Country of ref document: EP

Kind code of ref document: A1