WO2017010668A1 - 치열교정복합체 및 그의 제조방법 - Google Patents

치열교정복합체 및 그의 제조방법 Download PDF

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Publication number
WO2017010668A1
WO2017010668A1 PCT/KR2016/005055 KR2016005055W WO2017010668A1 WO 2017010668 A1 WO2017010668 A1 WO 2017010668A1 KR 2016005055 W KR2016005055 W KR 2016005055W WO 2017010668 A1 WO2017010668 A1 WO 2017010668A1
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WIPO (PCT)
Prior art keywords
orthodontic
hollow
biodegradable
complex
water
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PCT/KR2016/005055
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English (en)
French (fr)
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WO2017010668A8 (ko
Inventor
김태경
오명환
김윤기
Original Assignee
(주) 베리콤
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Application filed by (주) 베리콤 filed Critical (주) 베리콤
Priority to JP2018521802A priority Critical patent/JP6474530B2/ja
Priority to US15/742,505 priority patent/US11291528B2/en
Priority to EP16824585.0A priority patent/EP3332732B1/en
Publication of WO2017010668A1 publication Critical patent/WO2017010668A1/ko
Publication of WO2017010668A8 publication Critical patent/WO2017010668A8/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12—Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/14—Brackets; Fixing brackets to teeth
    • A61C7/16—Brackets; Fixing brackets to teeth specially adapted to be cemented to teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12—Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/20—Arch wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12—Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/28—Securing arch wire to bracket
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12—Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/28—Securing arch wire to bracket
    • A61C7/282—Buccal tubes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/02—Cellulose; Modified cellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C08L23/06—Polyethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/10—Homopolymers or copolymers of propene
    • C08L23/12—Polypropene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/02—Starch; Degradation products thereof, e.g. dextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/04—Starch derivatives, e.g. crosslinked derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
    • C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/02—Dextran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/12—Agar or agar-agar, i.e. mixture of agarose and agaropectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C2201/00—Material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C2201/00—Material properties
    • A61C2201/002—Material properties using colour effect, e.g. for identification purposes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/06—Biodegradable

Definitions

  • the present invention relates to an orthodontic complex and a method for manufacturing the same. More specifically, an orthodontic complex and a manufacturing method thereof, which can be used to easily orthodontic the teeth without a bracket by using a wire coated with a water-soluble or biodegradable material during orthodontic treatment. It's about how.
  • the brackets have the ability to guide the teeth by sliding along the wires while transferring the restorative force generated by the wires that are bent in the form of crooked teeth.
  • Brackets are very inconvenient because of their relatively large and complex structure, and are less aesthetic because of the visible brackets during treatment.
  • An object of the present invention is to provide a hollow orthodontic member comprising a water-soluble or biodegradable substance and a orthodontic complex comprising a wire located in the hollow.
  • Another object of the present invention is to provide an orthodontic complex that is easy to adhere to the tooth surface using an adhesive and that can be easily orthodontically corrected.
  • Another object of the present invention is to dissolve or biodegrade after a certain period of time during orthodontic procedures, creating a clearance between the wire and the adhesive, allowing it to slide and move along the teeth, making it easier to use teeth. To provide a calibration complex.
  • Another object of the present invention is to provide a method for producing the orthodontic complex.
  • An orthodontic complex comprising a wire for hollow etch orthodontic treatment,
  • Orthodontic members are provided with orthodontic complexes comprising water-soluble or biodegradable materials.
  • the tubular orthodontic member may have an inner diameter of 0.2 to 1.0 mm and a thickness of 0.001 to 0.5 mm.
  • the hollow polygonal conformal shape is n squared shape, and ⁇ may be one of 3 to 20 integer words.
  • the cross-section of the vacuum polygonal orthodontic member is a polygon of a hollow
  • the diameter of the circle inscribed in the hollow polygonal is 0.2 to 1.0 mm
  • the thickness of the hollow polygonal orthodontic orthodontic member is 0.001 to May be 5 mm.
  • the agglomerate polyhedron ⁇ large double n-pyramidal, and ⁇ may be any one of 3 to 20 integers.
  • the cross section of the hollow polygonal truncated pyramidal orthodontic member is a polyhedron with an increase in diameter, and the ratio (F / f, p) of the minimum diameter (f) to the maximum diameter (F) of the circle circumscribed to the hollow polygon is 1 ⁇ . May be ⁇ 10.
  • the minimum inner diameter (E) of the hollow park pyramidal orthodontic member is
  • the ratio (E / e, q) of the diameter (e) of the inner circumference may be l ⁇ q ⁇ 10.
  • the funnel-shaped orthodontic member may have a shape including a hollow truncated cone coupled to one end of a vacuum cylinder.
  • the funnel-type orthodontic member has a ratio (D / d, r) of the diameter (D) of the inner cylinder of the hollow cylinder to the maximum diameter (D) of the hollow cylinder of the hollow cone. May be 10
  • the orthodontic member may be any one selected from the group consisting of a transparent color or a combination of white, red, blue, yellow, green and idol.
  • the orthodontic member may be marked.
  • center portion of the mark is based on the length direction of the orthodontic member.
  • the center mark to be displayed, the work mark to display the length from the center part, and the end It may contain one or more of the end marks to display.
  • center mark may vary depending on the size of the inner or outer diameter of the orthodontic member.
  • the center mark may have a thickness of 0.1 to 5 mm.
  • the work mark may be one or more types of work lengths written on one side or both sides based on the center mark.
  • the end mark may be displayed at one end or both ends based on the length direction.
  • the color may be any one selected from the group consisting of white, red, blue, yellow, green, and a combination thereof, specifically white, black, red, yellow, yellow, yellow, green, green, blue, and blue. It can be blue, purple, or reddish purple.
  • the water-soluble or biodegradable substance may be gelatin, starch, starch derivative, salose, cellulose derivative, vegetable gum, agar, algin, alginate, carrageenan, chitosan, chitosan derivative, pectin, dextran, hyaluronic acid.
  • Onic acid polyacrylamide, polyvinylpyridone, polyvinyl alcohol, polyacrylic acid, polyethylene glycol, polypropylene glycol, polyethylene oxide, polypropylene oxide, biodegradable polyamide, biodegradable polyurethane and It may comprise one or more selected from biodegradable polyesterosis.
  • the water-soluble or biodegradable substance may also be used in the gelatin, starch, starch derivative,
  • Salulose cellulose derivative, vegetable gum, agar, algin, alginate, carrageenan, chitosan, chitosan derivative, pectin, dextran, hyaluronic acid, polyacrylamide, polyvinylpyrrolidone, polyvinyl alcohol,
  • polyacrylamide polyvinylpyrrolidone
  • polyvinyl alcohol For at least one 100 parts by weight selected from polyacrylic acid, polyethylene glycol, polypropylene glycol, polyethylene oxide, polypropylene oxide, biodegradable polyamide, biodegradable polyurethane, and biodegradable polyester resin, It may further comprise 1 to 200 parts by weight of compound represented by 1.
  • n is any one of 1 to 8.
  • the water-soluble or biodegradable material may include a compound represented by the following formula (2).
  • R is independently a hydrogen atom, a deuterium atom, a C1 to C6 alkyl group, or a C1 to C6 hydroxyalkyl group
  • ⁇ is a repeating unit.
  • the number average molecular weight of the compound represented by the formula (2) 1,000 to 9,000,000.
  • Preparing a composition for orthodontic members comprising a biodegradable material; coating the composition on a first wire; and drying the first wire coated with the composition to form a first wire coated with a water-soluble or biodegradable material.
  • a method of manufacturing the orthodontic complex comprising a step of manufacturing.
  • the method of manufacturing the orthodontic complex is to remove the first wire from the water-soluble or biodegradable material coated first wire after the step of manufacturing the first wire coated with the water-soluble or biodegradable material to remove the hollow.
  • the present invention can provide a hollow orthodontic member comprising a water-soluble or biodegradable substance and an orthodontic complex comprising a wire located in the hollow.
  • the present invention is easy to adhere to the tooth surface by using an adhesive, and can provide an orthodontic complex for easy tooth correction.
  • the present invention can provide an orthodontic complex that can be easily used by teeth by dissolving or biodegrading after a predetermined period of time during orthodontic procedures to form a gap between the wire and the adhesive, allowing it to slide along the teeth. .
  • the present invention can provide a method for producing the orthodontic complex.
  • FIG. 1 is a view illustrating a tube type and a square column type in the form of an orthodontic member according to the present invention.
  • FIG. 2 is a water-soluble or biodegradable tubular orthodontic member of the present invention, conventional bracket Alternatively, the side cross section of the tooth is schematically shown after applying a conventional small metal hollow tube.
  • FIG. 3 is a schematic diagram of an orthodontic member in which a mark of the present invention is displayed.
  • FIG. 4 is a view illustrating an orthodontic complex bonded with a wire according to an embodiment of the present invention.
  • FIG. 5 is a photograph of an orthodontic member marked with a mark according to an embodiment of the present invention.
  • FIG. 6 is a photograph of an orthodontic complex in which a mark and an orthodontic member and a wire are combined according to an embodiment of the present invention.
  • FIG. 7 shows a clinical trial procedure of orthodontics using the orthodontic complex of Example 1 of the present invention.
  • FIG. 8 is a front and side view of a clinical test result using an orthodontic complex according to Example 2 of the present invention.
  • FIG. 9 shows the clinical trial procedure of orthodontics using the orthodontic complex of Example 2 of the present invention.
  • FIG. 10 is a front and side view of a clinical test result using an orthodontic complex according to Example 2 of the present invention.
  • FIG. 11 shows the results of orthodontic correction using conventional brackets.
  • FIG. 12 shows a photograph of orthodontic correction using a metal tube in the form of a conventional hollow tube.
  • FIG. 1 is a schematic diagram of a tubular orthodontic member according to one embodiment of the present invention.
  • the orthodontic member of the present invention is a tube type, hollow polygonal shape, hollow polygonal pyramid shape, Hollow park pyramidal or fu id-type, containing water-soluble or biodegradable material.
  • the flow type orthodontic member has an inner diameter of 2 to 1.0 mm and a thickness of 0.001 to 1.0 mm.
  • the cross-section of the hollow polygonal orthodontic member is a hollow polygon, and the diameter of the circle inscribed in the hollow polygon is 0.2 to 1.0 mm. Is preferably 0.001 to 0.5 mm. However, the inner diameter and the diameter may vary depending on the diameter of the wire to be inserted into the hollow of the orthodontic member.
  • the hollow polygonal polygonal shape is n polygonal polygonal shape, n may be any one of 3 to 20 integers, preferably 4 to 15, and more preferably 4 to 8 integers, More preferably, it may be a four-hole hollow quadrilateral.
  • the ratio (E / e, q) of the minimum inner diameter (e) to the maximum inner diameter (E) of the hollow cone pyramidal orthodontic member may be l ⁇ q ⁇ 10, preferably 2 ⁇ q ⁇ 5, more
  • the cross section of the hollow polygonal truncated pyramidal orthodontic member is a polygon of hollow, and a ratio (F / f, p) of a minimum diameter (f) to a maximum diameter (F) of a circle circumscribed to the polygon of the vacuum is 1 ⁇ . ⁇ ⁇ 10, preferably 2 ⁇ p ⁇ 5, more preferably 3 ⁇ p ⁇ 4.
  • the hollow of a hollow polygonal formations n pyramid formation, and ⁇ is any one of a number of days 3 to 20, still water, and preferably from any one of days 4 to 15, more preferably from 4 to 8, still water.
  • the funnel-shaped orthodontic member includes a hollow truncated cone coupled to one end of a hollow cylinder, and the inside of the hollow cylindrical cylinder with respect to the diameter (D) of the maximum inner circumference of the hollow truncated cone.
  • the ratio (D / d, r) of the diameter (d) may be l ⁇ r ⁇ 10.
  • the ratio may be preferably 2 ⁇ r ⁇ 5, more preferably 3 ⁇ r ⁇ 4.
  • the funnel-shaped orthodontic member may have a shape including a hollow polygonal pyramid coupled to one end of a hollow polygonal polygon, and the maximum diameter of the circle circumscribed to the polygon of the cross-sectional authentication hole of the hollow polygonal pyramid (C).
  • the ratio (C / c, s) of the minimum diameter c to s may be l ⁇ s ⁇ 10, preferably 2 ⁇ s ⁇ 5, and more preferably 3 ⁇ s ⁇ 4.
  • the dental orthodontic member 10 is provided for orthodontic correction.
  • the orthodontic complex 20 including the wire 30 is manufactured by inserting the wire 30 into the orthodontic member 10, and the wire wrapped around the member is bonded to the teeth by using resin on the crooked teeth. Restorative force occurs in wires that are warped and bonded in a crooked form, which is transferred to the tooth with orthodontic force to move the tooth into the medium.
  • the orthodontic member is water-soluble or biodegradable and melts in the oral cavity, a gap is formed between the teeth and the resin so that the teeth can slide along the wire.
  • the orthodontic member may be made to be transparent for working convenience, or may be manufactured in white, red, blue, yellow, green, and a combination thereof, specifically transparent or white, black, red, Yellow, yellow, yellow green, green, cyan, blue, blue purple, purple or reddish purple can be produced.
  • the orthodontic member 10 may also mark marks 100, 200 and 300 for convenience of operation.
  • the core portion is displayed on the basis of the length direction of the orthodontic member 10.
  • It may be an increase mark 100, a work mark 200 for displaying a distance from the center portion, or an end mark 300 for displaying an end.
  • center mark may vary depending on the size of the inner or outer diameter of the orthodontic member.
  • the center mark may have a thickness of 0.1 to 5 mm.
  • the work mark may include one or more work lengths on one side or both sides based on the center mark.
  • the end mark may be displayed at one end or both ends based on the length direction.
  • the color of the mark may be any one selected from the group consisting of white, red, blue, yellow, green and a mixture of these colors, specifically white, black, red, yellow, yellow, yellow, green, blue, It can be blue, blue, purple or reddish purple.
  • the center mark can be used to easily match the center of the orthodontic member with the center of the wire, and the work mark can be used to easily find the working length from the core. The end of the orthodontic member can be easily checked.
  • composition for orthodontic members of the present invention is water-soluble or biodegradable.
  • the coating composition for orthodontic members may be used to coat orthodontic wires or to prepare orthodontic members having hollows.
  • the orthodontic member composition may include 10 to 100 parts by weight of a water-soluble or biodegradable material; and 20 to 990 parts by weight of a solvent including water.
  • the water-soluble or biodegradable substance may be dissolved or decomposed in the oral cavity.
  • the water-soluble or biodegradable material is gelatin, starch, starch derivatives, trehalose derivatives, as agarose, saelreul saelreul flora seonggeom, agar, algin, alginate, carrageenan, Quito new and chitosan Derivatives, pectin, dextran, hyaluronic acid, polyacrylamide, polyvinylpyridone, polyvinyl alcohol, polyacrylic acid, polyethylene glycol, polypropylene glycol, It may be at least one selected from polyethylhexoxide, polypropylene oxide, biodegradable polyamide, biodegradable polyurethane and biodegradable polyesterosis.
  • the biodegradable polyamide may be polylactic acid or modified polylactic acid.
  • water-soluble or biodegradable substance may be used in the gelatin, starch, starch derivative,
  • polyacrylamide polyvinylpyrrolidone
  • polyvinyl alcohol For one or more 100 parts by weight selected from polyacrylic acid, polyethylene glycol, polypropylene glycol, polyethylene oxide, polypropylene oxide, biodegradable polyamide, biodegradable polyurethane, and biodegradable polyester, It may further comprise 1 to 200 parts by weight of the compound represented by.
  • n is any one of 1 to 8.
  • the compound represented by Chemical Formula 1 may be sorbitol and glycerin.
  • the water-soluble or biodegradable substance may include 5 to 100 parts by weight of glycerin and 1 to 100 parts by weight of sorbine, based on 100 parts by weight of gelatin.
  • the water-soluble or biodegradable substance may further include 1 to 250 parts by weight of purified water.
  • the gelatin may have a jelly strength of 30 to 500 bloom, preferably 100 to 400 bloom.
  • the jelly strength is a representative physical property of gelatin.
  • the bloom value is used to express the strength of the gelatin, and the jelly strength is 6.67% according to the British Standard (BS 757).
  • water-soluble or biodegradable substance is represented by the following formula (2)
  • the compound, a cell may contain a rose derivative.
  • R is independently a hydrogen atom, a deuterium atom, a C1 to C6 alkyl group, or a C1 to C6 hydroxyalkyl group, ⁇ is a repeating unit.
  • the number average molecular weight of the compound represented by Formula 2 is 1,000 to 9,000,000.
  • the polyethylene glycol is in a solid state having a weight average molecular weight of 1,000 to 100,000.
  • the water-soluble or biodegradable polymer may include modified starch and vegetable gum. .
  • the compound represented by Chemical Formula 2 may be hydroxypropylmethyl salose.
  • the hydroxypropyl methyl cell has a degree of substitution of 15 to 15 methoxy group
  • the hydroxypropyl methylcell has a temperature of 20 ° C. and a weight of 2 weight ⁇ 3 ⁇ 4
  • Viscosities in concentrations can be from 1 to 35 mPa ⁇ s.
  • the solvent may further include a linear or pulverized C2 to C9 alcohol.
  • the weight ratio of water and alcohol in the solvent may be 100: 0 to 5:95.
  • composition for orthodontic member may further include at least one stabilizer selected from sorbate, salicylate and benzoate.
  • the content of the stabilizer may be contained in an amount of 0.01 to 5 parts by weight based on 100 parts by weight of a water-soluble or biodegradable substance. When the content of the stabilizer is less than 0.01, it does not show a preservation effect. Not deteriorate mechanical properties.
  • composition for orthodontic members may further comprise pigments.
  • the pigments are natural food colors, tar food foods, beta carotene, copper sulfate,
  • Ferric oxide may be caramel, copper, sodium chlorophyllin or titanium oxide
  • the orthodontic coating composition may further include 0.1 to 5 parts by weight of the surfactant.
  • the surfactant may be polyethylene glycol, polysorbate, fatty acid.
  • Monoglycerol ester fatty acid polyglycol ester, fatty acid sorbitan ester, fatty acid sucrose ester, fatty acid alkanolamide, polyethylene glycol condensed nonionic surfactant.
  • the polyethylene glycol may be a solid having a molecular weight of 1,000 to 100,000.
  • composition for orthodontic members may further include a compound represented by the following formula (1).
  • n is any one of 1 to 8 integers.
  • Step (a) is performed by mixing gelatin, glycerin, sorbitan solution and purified water to form a composition.
  • the solvent of the solution may be water.
  • the water-soluble or biodegradable substance is a compound represented by the following Chemical Formula 2.
  • R is independently a hydrogen atom, a deuterium atom, a C1 to C6 alkyl group, or a C1 to C6 hydroxyalkyl group, ⁇ is a repeating unit.
  • the number average molecular weight of the compound represented by Formula 2 is 1,000 to 9,000,000.
  • C1 to C6 alkyl group may preferably be CH3, and the C1 to C6 hydroxyalkyl group may preferably be CH2-CHOH-CH3.
  • the method may further comprise step (a-1) of maintaining the composition at a temperature of 50 to 100 ° C.
  • Step (a-1) is preferably 55 to 95 ° C. More preferably, it can be carried out at 60 to 90 ° C.
  • the components of the composition may be mixed evenly.
  • Step (a-1) may preferably be performed for 2 to 6 hours but may vary depending on the temperature of step (a-1). Step (a-1) may also be used to deflate under vacuum. May be additionally included.
  • the method may further include the step (a-2) of maintaining the composition at a temperature of 50 to 65 ° C.
  • Step (a-2) is preferably 53 to 53 ° C. It may be carried out at 62 ° C, more preferably at 54 to 60 ° C.
  • a wire is prepared, and the composition is coated on the surface of the wire to prepare a wire coated with the composition (step b).
  • the coating of step (b) may preferably vary depending on the gelation temperature of the composition.
  • the composition may be uniformly coated on the wire above the gelation temperature, and the gelation temperature.
  • the composition can be uniformly coated on the wire below the gelling temperature.
  • gelatin gels at low temperatures it is desirable to coat above the gelling temperature, since HPMC gels at higher temperatures. Coating at a temperature below the gelling temperature is preferred.
  • the orthodontic member may be a rib type, a vacuum polygonal shape, a funnel type, a hollow park pyramid shape, or a hollow polygonal shape pyramid shape.
  • the composition is dried on the wire coated with the composition to prepare an orthodontic member including the wire and the wire in the hollow (step c).
  • Step (c) is preferably performed at 25 to 30 ° C and relative humidity of 20 to 40%. Step (C) may be performed until the composition reaches equilibrium, and may be performed for 12 to 72 hours if performed under the above conditions.
  • the composition may be hardened to a gel close to a solid.
  • Orthodontic member preferably has a strength enough to while having a tooth 'flexibility unbroken even bending of the wires for correction to be suitable for arrangement at the time when applying the orthodontic treatment maintained the hollow.
  • the orthodontic member is manufactured by removing the wire from the orthodontic member in which the hollow air is bonded (step d).
  • the method may further include processing oil on the surface of the orthodontic member (step d-l).
  • the oil may be mineral oil, silicon oil, vegetable oil, or the like.
  • the coating solution was prepared using Cellulose (HPMC). After mixing 585 parts by weight of purified water and 1 part by weight of potassium sorbate, the temperature of the solution was heated to 90 ° C. HPMC was dissolved by injecting 220 parts by weight of HPMC and 194 parts by weight of ethanol to a solution at 90 ° C. for 2 hours. The prepared composition was aged at 55 ° C. for 12 hours to prepare a coating composition for orthodontic members. .
  • HPMC Cellulose
  • the coating solution prepared according to Preparation Example 1 is placed in a supporting liquid container maintained at 45 ° C.
  • a stainless steel straight wire having a length of 100 mm and a diameter of 0.5 mm was fixed with a fixed screw, and the wire was coated with paraffin.
  • the wire was immersed in a coating solution, immediately pulled out, and the coating solution was uniformly coated.
  • the coating solution prepared according to Preparation Example 2 was placed in a supporting liquid container maintained at 20 ° C. Wires 100 mm long and 0.5 mm in diameter were fixed with a set screw, and the wires were coated with paraffin. The wires were immersed in a coating solution, immediately pulled out, and the coating solution was uniformly coated. Referring to FIGS. 3 and 4, After drying for 24 hours at a relative humidity of 25% at room temperature, an edible dye was used on the coating to display a white center mark, a work mark, and an end mark, and wires were removed to prepare an orthodontic member with a white mark.
  • a dental orthodontic complex in which a center line is inserted into a orthodontic member having a center mark, a work mark, and an end mark of Manufacturing Example 4 is inserted, and the center line and the center mark are aligned to form a orthodontic complex Prepared.
  • Phase 3 ⁇ 4 Test 1 Correction of Toothpaste Correction of Lower Levels
  • FIG. 7 The process is shown in FIG. 7 and the front and side pictures are shown in FIG.
  • nickel-titanium wire was inserted into the water-soluble tube prepared according to Production Example 3 in addition to oral cavity, and the wire-inserted lube was directly adhered to the tooth. This appeared to be possible.
  • the simple structure was aesthetic, and there was no soft tissue stimulation by the device, so it was easy to maintain oral hygiene.
  • the orthodontic complexes combined with the wires prepared according to Example 2 are simple in structure and aesthetic, free from soft tissue stimulation by the device, and comfortable for oral hygiene. I could keep it.
  • FIG. 2 shows a wire inserted into a water-soluble tube orthodontic member of the present invention.
  • Fig. 11 is a schematic cross-sectional view of an orthodontic composite and a conventional bracket or small hollow tube, and Fig. 11 shows the results of orthodontic treatment using a conventional bracket.
  • the wire was used to bind the bracket so that it did not fall out of the bracket. As a result, the bracket and its accessories appeared to stimulate the oral internal tissue.
  • FIG. 12 shows a photo of an orthodontic calibration using a hollow tube-shaped rib.
  • the hollow tube-type tube can be applied only to the partial orthodontic treatment limited to the anterior portion and that a lot of time is required for wire insertion.
  • the present invention can provide a orthodontic orthodontic member comprising a water-soluble or biodegradable material and an orthodontic complex comprising a wire located in the hollow.
  • the present invention provides an orthodontic complex that is easy to adhere to the tooth surface by using an adhesive and that can be easily orthodonticly corrected.
  • the present invention can provide an orthodontic complex that can be easily used by teeth by dissolving or biodegrading after a predetermined period of time during orthodontic procedures to form a gap between the wire and the adhesive, allowing it to slide along the teeth. .
  • the present invention can provide a method for producing the orthodontic complex.

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Abstract

본 발명은 튜브 (tube)형,중공 다각기둥형, 중공 다각뿔대형,중공 원뿔대형 또는 깔때기 (funnel)형의 치열교정부재; 및 상기 치열교정부재의 중공에 치열교정용 와이어를 포함하는 치열교정복합체이고,상기치열교정부재는 수용성 또는 생분해성 물질을 포함하는 치열교정복합체에 관한것이다. 이에 의하여,본 발명의 치열교정복합체는 간편하게 치아에 접착함으로써 치아교정 시술을 할 수 있다.

Description

명세서
발명의 명칭:치열교정복합체및그의제조방법 기술분야
[1] 본발명은치열교정복합체및그의제조방법에관한것으로,보다상세하게는 교정시술시수용성또는생분해성물질로코팅된와이어를사용하여브라켓 없이간편하게치아교정시술을할수있는치열교정복합체및그의제조방법에 관한것이다.
배경기술
[2] 치아의배열이가지런하지않거나위아래맞물림꾀상태가정상의위치를 벗어난상태를 "부정교합' '이라하며이를바로잡아주는치료를교정치료라 한다.부정교합일경우에는보기에도좋지않을뿐만아니라발음이나 저작기능에도장애가유발되기때문에，부정교합인치아를잡아주기위한 다양한치열교정장치가사용되고있다.
[3] 그증가장대표적인치열교정장치는브라켓으로,교정용와이어와함께
사용하여치아를이동시킨다.기본적으로브라켓은비뚤어진치열형태대로 휘어진와이어에서생기는복원력을치아에전달하면서，치아가와이어를따라 미끄러져이동하도록가이드하는기능이있다.
[4] 하지만브라켓은상대적으로크고복잡한구조때문에매우불편하며，치료 중에는브라켓이보이기때문에심미성이떨어진다.
[5] 이러한단점을보완하기위하여소형증공관형태의미니튜브와와이어를 이용한치열교정방법이사용되고있으며，이러한시술방법은
대한민국등록특허제 1,234,205호 '치열교정치료용류브，에기재되어있다.
[6] 그러나미니튜브를이용한치열교정방법은다음과같은근본적문제점을 지니고있다.
[7] 첫째,불규칙하게비뚤어진치아에붙어있는 0.5mm보다작은내경을갖는 류브에와이어를끼우는것이매우어렵다.
[8] 둘째,목뒤에서부터와이어를끼우는것은불가능하기때문에미니류브는 구치부 (어금니)에사용할수없고，전치부 (앞니)의한정된부분의교정치료에만 사용할수있다.
[9] 따라서，환자의블편감은최소화하면서,간편하고보편적인치아교정시술이 가능한방법의개발이요구되는실정이다.
발명의상세한설명
기술적과제
[10] 본발명의목적은수용성또는생분해성물질올포함하는중공형치열교정부재 및상기중공에위치하는와이어를포함하는치열교정복합체를제공하는 것이다. [11] 본발명의다른목적은접착제를사용하여치아표면에접착하기쉬우며， 간편하게치아교정시술을할수있는치열교정복합체를제공하는것이다.
[12] 본발명의다른목적은치열교정시술시소정기간후용해되거나생분해되어 와이어와접착제사이에간극 (clearance)을형성함으로써，치아가와이어를따라 미끄러지면서이동할수있도록하여치아이동이용이한치열교정복합체를 제공하는것이다.
[13] 본발명의다른목적은상기치열교정복합체의제조방법을제공하는데있다. 과제해결수단
[14] 본발명의일측면에따르면,류브 (tube)형，중공다각기등형，증공다각뿔대형, 중공원뿔대형또는깔때기 (funnel)형의치열교정부재;및상기치열교정부재의 . 중공에치열교정용와이어를포함하는치열교정복합체이고,상기
치열교정부재는수용성또는생분해성물질을포함하는치열교정복합체가 제공된다.
[15] 또한상기튜브형치열교정부재는내경이 0.2내지 1.0 mm이고，두께가 0.001 내지 0.5 mm일수있다.
[16] 또한상기중공다각기등형은 n각기등형이고 , η은 3내지 20의정수증어느 하나일수있다.
[17] 또한상기증공다각기등형치열교정부재의단면이중공의다각형이고，상기 중공의다각형에내접하는원의직경은 0.2내지 1.0 mm이고,상기중공 다각기등형치열교정부재의두께는 0.001내지 5 mm일수있다.
[18] 또한상기증공다각쁄대형이중공의 n각뿔대형이고 , η은 3내지 20의정수중 어느하나일있다.
[19] 또한상기중공다각뿔대형치열교정부재의단면이증공의다각형이고，상기 중공의다각형에외접하는원의최대직경 (F)대비최소직경 (f)의비 (F/f, p)가 1<ρ≤10일수있다.
[20] 또한상기중공원뿔대형치열교정부재의최대내주의직경 (E)대비최소
내주의직경 (e)의비 (E/e, q)가 l<q≤10일수있다.
[21] 또한상기깔때기형의치열교정부재가증공형원기등의일단부에결합된 중공형원뿔대를포함하는형태일수있다.
[22] 또한상기깔때기형의치열교정부재는상기중공형원뿔대의최대내주의 ' 직경 (D)대비상기중공형원기둥의내주의직경 (d)의비 (D/d, r)가 l<r≤10일수 있다.
[23] 또한상기치열교정부재는색상이투명하거나또는백색,적색,청색，황색， 녹색및이돌의흔합색으로이루어진군에서선택된어느하나일수있다.
[24] 또한상기치열교정부재는마크가표시된것일수있다.
[25] 또한상기마크가상기치열교정부재의길이방향을기준으로중심부를
표시하는중심마크,상기중심부로부터의길이를표시하는작업마크，끝단을 표시하는끝단마크중 1종이상을포함할수있다.
[26] 또한상기중심마크가상기치열교정부재의내경또는외경의크기에따라
소정의색상으로표시될수있다.
[27] 또한상기중심마크는두께가 0.1내지 5mm일수있다.
[28] 상기작업마크가상기중심마크를기준으로일측면또는양측면에 1종이상의 작업길이를기재한것일수있다.
[29] 상기끝단마크가길이방향을기준으로일말단또는양말단에표시된것일수 있다.
[30] 또한상기색상은백색,적색,청색,황색,녹색및이들의흔합색으로이루어진 군에서선택된어느하나일수있고,구체적으로백색,검은색，적색，황적색, 황색,황록색,녹색,청록색，청색,청자색,보라색또는적자색일수있다.
[31] 또한상기수용성또는생분해성물질이젤라틴，전분,전분유도체，샐를로오스， 셀를로오스유도체,식물성검，아가,알긴,알긴산염,카라기난,키토산， 키토산유도체，펙틴,덱스트란，히알루로닉에시드，폴리아크릴아미드， 폴리비닐피를리돈,폴리비닐알코올，폴리아크릴릭에시드,폴리에틸렌글라이콜, 폴리프로필렌글라이콜，폴리에틸렌옥사이드,폴리프로필렌옥사이드，생분해성 폴리아미드,생분해성폴리우레탄및생분해성폴리에스터증에서선택된 1종 이상을포함할수있다.
[32] 또한상기수용성또는생분해성물질이상기젤라틴,전분,전분유도체,
샐를로오스,셀를로오스유도체，식물성검 ,아가，알긴,알긴산염 ,카라기난, 키토산,키토산유도체,펙틴,덱스트란，히알루로닉에시드，폴리아크릴아미드， 폴리비닐피롤리돈，폴리비닐알코올,폴리아크릴릭에시드，폴리에틸렌글라이콜, 폴리프로필렌글라이콜，폴리에틸렌옥사이드，폴리프로필렌옥사이드，생분해성 폴리아미드，생분해성폴리우레탄및생분해성폴리에스터증에서선택된 1종 이상 100중량부에대하여,아래화학식 1로표시되는화합물 1내지 200증량부를 추가로포함할수있다.
[33] [화학식 1]
Figure imgf000005_0001
[35] 상기화학식 1에서 n은 1내지 8의정수중어느하나이다. 또한상기수용성또는생분해성물질이아래화학식 2로표시되는화합물을 포함할수있다.
[화학식 2]
Figure imgf000006_0001
[39] 상기화학식 2에서 R은각각독립적으로수소원자，중수소원자， C1내지 C6 알킬기또는, C1내지 C6히드록시알킬기이이고 , η은반복단위이고.상기화학식 2로표시되는화합물의수평균분자량이 1,000내지 9,000,000이다.
[4이 본발명의다른하나의측면에따르면,물을포함하는용매및수용성또는
생분해성물질을포함하는치열교정부재용조성물을준비하는단계;상기 조성물을제 1와이어에코팅하는단계;및상기조성물이코팅된제 1와이어를 건조하여수용성또는생분해성물질이코팅된제 1와이어를제조하는단계;를 포함하는치열교정복합체의제조방법이제공된다.
[41] 또한치열교정복합체의제조방법은상기수용성또는생분해성물질이코팅된 제 1와이어를제조하는단계후에상기수용성또는생분해성물질이코팅된제 1 와이어에서상기계 1와이어를제거하여중공을갖는치열교정부재를제조하는 단계;및제 2와이어를상기치열교정부재의중공에삽입하여치열교정복합체를 제조하는단계;를추가로포함할수있다.
발명의효과
[42] 본발명은수용성또는생분해성물질올포함하는중공형치열교정부재및 상기중공에위치하는와이어를포함하는치열교정복합체를제공할수있다.
[43] 본발명은접착제를사용하여치아표면에접착하기쉬우며，간편하게치아 교정시술을할수있는치열교정복합체를제공할수있다.
[44] 본발명은치열교정시술시소정기간후용해되거나생분해되어와이어와 접착제사이에간극을형성함으로써，치아가와이어를따라미끄러지면서 이동할수있도록하여치아이동이용이한치열교정복합체를제공할수있다.
[45] 본발명은상기치열교정복합체의제조방법을제공할수있다.
도면의간단한설명
[46] 도 1은본발명의치열교정부재의형태중튜브형과사각기둥형을묘사한
개략도이다.
[47] 도 2는본발명의수용성또는생분해성튜브형치열교정부재,종래의브라켓 또는종래의소형금속중공관을적용한후치아의측단면을개략적으로나타낸 것이다.
[48] 도 3은본발명의마크가표시된치열교정부재의개략도이다.
[49] 도 4는본발명의일실시예에따른와이어 결합한치열교정복합체의
개략도이다.
[50] 도 5는본발명의일실시예에따른마크가표시된치열교정부재의사진이다.
[51] 도 6은본발명의일실시예에따른마크가표시된치열교정부재와와이어를 결합한치열교정복합체의사진이다.
[52] 도 7은본발명의실시예 1의치열교정복합체를적용한치열교정의임상시험 과정을나타낸것이다.
[53] 도 8은본발명의실시예 2에따른치열교정복합체를이용한임상시험결과의 정면과측면사진을나타낸것이다.
[54] 도 9는본발명의실시예 2의치열교정복합체를이용한치열교정의임상시험 과정을나타낸것이다.
[55] 도 10은본발명의실시예 2에따른치열교정복합체를이용한임상시험결과의 정면과측면사진을나타낸것이다.
[56] 도 11는종래의브라켓을이용한치열교정의결과를나타낸것이다.
[57] 도 12은종래의중공관형태의금속튜브를이용한치열교정의사진을나타낸 것이다.
발명의실시를위한최선의형태
[58] 이하,본발명이속하는기술분야에서통상의지식을가진자가용이하게
실시할수있도록첨부된도면을참조하여본발명의실시예를상세히
설명하도록한다.
[59] 그러나,이하의설명은본발명을특정한실시형태에대해한정하려는것이 아니며，본발명을설명함에있어서관련된공지기술에대한구체적인설명이 본발명의요지를흐릴수있다고판단되는경우그상세한설명을생략한다.
[60] 본원에서사용한용어는단지특정한실시예를설명하기위해사용된것으로， 본발명을한정하려는의도가아니다.단수의표현은문맥상명백하게다르게 뜻하지않는한，복수의표현을포함한다.본출원에서， "포함하다"또는 "가지다" 둥의용어는명세서상에기재된특징，슷자，단계，동작,구성요소，또는이들을 조합한것이존재함을지정하려는것이지，하나또는그이상의다른특징들이나 숫자，단계，동작,구성요소,또는이들을조합한것들의존재또는부가가능성을 미리배제하지않는것으로이해되어야한다.
[61]
[62] 도 1은본발명의일실시예에따른튜브형치열교정부재의개략도이다.
[63] 이하,도 1을참조하여본발명의치열교정부재에대해설명하도록한다.
[64] 본발명의치열교정부재는류브 (tube)형,중공다각기등형,중공다각뿔대형, 중공원뿔대형또는깔때기 (fu id)형이고，수용성또는생분해성물질을 포함한다.
[65] 상기류브형치열교정부재는내경은으2내지 1.0 mm이고，두께는 0.001내지
0.5 mm인것이바람직하다.
[66] 또한,상기중공다각기등형치열교정부재의단면은중공의 다각형이고，상기 중공의 다각형에내접하는원의직경은 0.2내지 1.0 mm이다.또한，상기증공 다각기둥형치열교정부재의두께는 0.001내지 0.5 mm인것이바람직하다. 그러나，상기내경 및직경은치열교정부재의중공에삽입될와이어의 직경에 따라달라질수있다.
[67] 상기중공다각기등형은 n각다각기등형이고， n은 3내지 20의 정수중어느 하나일수있고，바람직하게는 4내지 15，더욱바람직하게는 4내지 8의 정수중 어느하나일수있고，보다더욱바람직하게는 4인중공 4각기둥형일수있다.
[68] 상기중공원뿔대형 치열교정부재의 최대내주의 직경 (E)대비 최소내주의 직경 (e)의비 (E/e, q)는 l<q≤10일수있고，바람직하게는 2≤q≤5,더욱
바람직하게는 3≤q≤4일수있다.
[69] 상기중공다각뿔대형치열교정부재의단면은중공의다각형이고,상기증공의 다각형에외접하는원의최대직경 (F)대비최소직경 (f)의 비 (F/f, p)가 1<ρ< 10일 수있고,바람직하게는 2≤p≤5,더욱바람직하게는 3≤p≤4일수있다.
[70] 상기중공다각뿔대형의중공은 n각뿔대형이고 , η은 3내지 20의 정수중어느 하나일수있고，바람직하게는 4내지 15，더욱바람직하게는 4내지 8의 정수중 어느하나일수있다.
[71] 상기깔때기형의치열교정부재는중공형원기등의 일단부에 결합된중공형 원뿔대를포함하는형태이고,상기중공형원뿔대의 최대내주의 직경 (D)대비 상기중공형 원기등의내주의직경 (d)의 비 (D/d, r)는 l<r≤10일수있다.상기 비는바람직하게는 2≤r≤5,더욱바람직하게는 3≤r≤4일수있다.또한，상기 깔대기형의치열교정부재는중공형다각기등의 일단부에 결합된중공형 다각뿔대를포함하는형태일수있고,상기중공형다각뿔대의 단면인증공의 다각형에외접하는원의최대직경 (C)대비 최소직경 (c)의 비 (C/c, s)가 l<s<10 일수있고，바람직하게는 2≤s≤5,더욱바람직하게는 3≤s≤4일수있다.
[72] 도 4및도 6을참고하면，상기치열교정부재 (10)의중공에치열교정용
와이어 (30)을포함하는치열교정복합체 (20)를상기치열교정부재 (10)에 와이어 (30)를삽입하여 제조하고,상기부재가감싸고있는와이어를비뚤어진 치열에 레진을이용하여치아에접착한다.비뚤어진치열형태대로휘어서 접착된와이어에서는복원력이발생하고,이는접착제인레진을매개체로 치아를이동시킬수있는교정력으로치아에 전달된다.이와동시에
치열교정부재는수용성또는생분해성으로구강내에서녹기 때문에와이아와 레진사이에는간극이형성되어,치아는와이어를따라미끄러지면서 이동할수 있다. [73] 또한상기치열교정부재는작업상편의를위하여색상을투명하게하거나또는 백색,적색，청색，황색，녹색및이들의흔합색으로제조할수있고,구체적으로 투명하거나백색，검은색，적색，황적색，황색，황록색，녹색,청록색，청색， 청자색，보라색또는적자색을제조할수있다.
[74] 또한도 3및도 5를참고하면,또한상기치열교정부재 (10)는작업상편의를 위하여마크 (100, 200, 300)를표시할수있다.
[75] 또한상기치열교정부재 (10)의길이방향을기준으로증심부를표시하는
증심마크 (100),상기중심부로부터의거리를표시하는작업마크 (200)，또는 끝단을표시하는끝단마크 (300)일수있다.
[76] 또한상기중심마크가상기치열교정부재의내경또는외경의크기에따라
소정의색상으로표시될수있다.
[77] 또한상기중심마크는두께가 0.1내지 5mm일수있다.
[78] 또한상기작업마크를상기중심마크를기준으로일측면또는양측면에 1종 이상의작업길이를기재할수있다.
[79] 또한상기끝단마크를길이방향을기준으로일말단또는양말단에표시할수 있다.
[80] 또한상기마크의색상은백색,적색，청색,황색，녹색및이들의혼합색으로 이루어진군에서선택된어느하나일수있고,구체적으로백색，검은색，적색， 황적색,황색，황록색，녹색，청록색，청색,청자색,보라색또는적자색일수있다. 마크가표시된치열교정부재를사용할경우상기중심마크를이용하여 치열교정부재의중심과와이어의중심을쉽게일치시킬수있고,작업마크를 이용하여용이하게증심부로부터의작업길이를알수있으며,끝단마크를 이용하여치열교정용부재의말단을쉽게확인할수있다.
[81]
[82] 이하,본발명의상기수용성또는생분해성물질을제조하는데사용하는
치열교정부재용조성물에대해설명하도록한다.
[83] 본발명의치열교정부재용조성물은수용성또는생분해성물질;및물을
포함하는용제；를포함할수있다.또한,상기치열교정부재용코팅조성물은 치열교정용와이어에코팅하는데사용하거나중공을갖는치열교정부재를 제조하는데사용할수있다.
[84] 바람직하게는,상기치열교정부재용조성물은수용성또는생분해성물질 10 내지 100중량부;및물을포함하는용제 20내지 990중량부；를포함할수있다.
[85] 상기수용성또는생분해성물질은구강내에서녹거나분해될수있는
물질이라면어느것이든가능하나,바람직하게는상기수용성또는생분해성 물질이젤라틴,전분,전분유도체,샐를로오스，샐를로오스유도체,식물성검， 아가,알긴，알긴산염,카라기난，키토신 ·,키토산유도체，펙틴,덱스트란， 히알루로닉에시드,폴리아크릴아미드，폴리비닐피를리돈，폴리비닐알코올, 폴리아크릴릭에시드,폴리에틸렌글라이콜，폴리프로필렌글라이콜， 폴리에틸헥옥사이드，폴리프로필렌옥사이드，생분해성폴리아미드，생분해성 폴리우레탄및생분해성폴리에스터증에서선택된 1종이상일수있다.
[86] 상기생분해성폴리아미드는폴리락틱산，변성폴리락틱산일수있다.
[87] 또한상기수용성또는생분해성물질이상기젤라틴,전분,전분유도체,
셀를로오스,셀를로오스유도체,식물성검,아가,알긴,알긴산염，카라기난, 키토산，키토산유도체,펙틴,텍스트란，히알루로닉에시드,폴리아크릴아미드, 폴리비닐피롤리돈,폴리비닐알코올,폴리아크릴릭에시드，폴리에틸렌글라이콜， 폴리프로필렌글라이콜，폴리에틸렌옥사이드，폴리프로필렌옥사이드，생분해성 폴리아미드,생분해성폴리우레탄및생분해성폴리에스터중에서선택된 1종 이상 100중량부에대하여，아래화학식 1로표시되는화합물 1내지 200증량부를 추가로포함할수있다.
[88] [화학식 1]
Figure imgf000010_0001
[90] 상기화학식 1에서 n은 1내지 8의정수증어느하나이다.
[91]
[92] 상기화학식 1로표시되는화합물은바람직하게는솔비톨및글리세린일수 있다.
[93] 상기수용성또는생분해성물질은더욱바람직하게는젤라틴 100중량부에 대하여，글리세린 5내지 100중량부및솔비를 1내지 100중량부를포함할수 있다.
[94] 또한,상기수용성또는생분해성물질은정제수 1내지 250중량부를추가로 포함할수있다.
[95] 상기젤라틴은젤리강도는 30내지 500 Bloom일수있고，바람직하게는 100 내지 400 Bloom일수있다.
[96] 상기젤리강도란젤라틴의대표적인물리적특성이다.블룸값 (Bloom Value)은 젤라틴의강도를표시하는데사용되며，젤리강도 (Jelly strength)는 BS기준 (British Standard: BS 757)에따라 6.67%의젤라틴용액을젤리강도계의
폴런저 (Plunger)가표면으로부터 4mm깊이로눌렀을때필요한힘 (Force)으로 정의할수있다. [97]
[98] 또한상기수용성또는생분해성물질이아래화학식 2로표시되는
화합물인셀를로오스유도체를포함할수있다.
[99] [화학식 2]
Figure imgf000011_0001
[101] 상기화학식 2에서 R은각각독립적으로수소원자，중수소원자， C1내자 C6 알킬기또는, C1내지 C6히드록시알킬기이고 , η은반복단위이고.상기화학식 2로표시되는화합물의수평균분자량이 1,000내지 9,000,000이다.
[102] 상기폴리에틸렌글라이콜은중량평균분자량이 1,000내지 100,000인고체상인 것이바람직하다. -
[103] 상기수용성또는생분해성고분자는변성전분및식물성검등을포함할수 있다. .
[104] 상기화학식 2로표시되는화합물이히드록시프로필메틸샐를로오스일수 있다.
[105] 상기히드록시프로필메틸셀를로오스는메톡시기의치환도가 15내지
30%이고，히드록시프로폭시의치환도가 4내지 32%일수있다.
[106] 상기히드록시프로필메틸셀를로오스가 20°C의온도와 2중량 <¾수용액
농도에서점도가 1내지 35mPa.s일수있다.
[107] 상기용제가선형또는분쇄형의 C2내지 C9의알코올을추가로포함할수 있다.여기서용제에포함되는물과알코올의중량비는 100:0내지 5:95일수 있다.
[108] 상기치열교정부재용조성물이소르빈산염，살리신산염및벤조산염중에서 선택된 1종이상의안정제를추가로포함할수있다.
[109] 상기안정제의함량은수용성또는생분해성물질 100중량부에대하여 0.01 내지 5중량부포함할수있다.안정제의함량이 0.01미만인때에는보존효과를 보이지않고， 5중량부를초과하면제조된치열교정부재의기계적물성을 저하시켜바람지하지않다.
[1 1이 상기치열교정부재용조성물이색소를추가로포함할수있다.
[111] 상기색소는천연식용색소,타르계식용색소，베타카로틴，황산구리，
산화제이철ᅳ캐러멜，구리，철클로로필린나트륨또는산화티타늄일수있다 [112] 상기치열교정용코팅조성물은계면활성제 0.1내지 5중량부를추가로포함할 수있다.
[113] 상기계면활성제는폴리에틸렌글리콜，폴리소르베이트，지방산
모노글리세린에스테르,지방산폴리글리콜에스테르，지방산소르비탄에스테르, 지방산자당에스테르,지방산알칸올아미드，폴리에틸렌글뫼콜축합형비이온 계면활성제일수있다.
[114] 상기폴리에틸렌글라이콜은분자량이 1,000내지 100,000인고체상일수있다.
[115]
[116] 이하，본발명의치열교정부재의제조방법에대해설명하도록한다.
[117] 먼저,수용성또는생분해성물질및정제수를혼합하여치열교정부재용
조성물을제조한다 (단계 a).
[118] 여기서치열교정부재용조성물은하기화학식 1로표시되는화합물을추가로 포함할수밌다.
[119] [화학식 1]
[120]
Figure imgf000012_0001
[121 ] 상기화학식 1에서
[122] n은 1내지 8의정수중어느하나이다.
[123] 단계 (a)는젤라틴，글리세린，솔비를용액및정제수를혼합하여조성물을
제조하는단계를포함할수있다.상기솔비를용액의용매는물일수있다.
[124] 여기서수용성또는생분해성물질은아래화학식 2로표시되는화합물일
수있다.
[125] [화학식 2]
Figure imgf000013_0001
[127] 상기화학식 2에서 R은각각독립적으로수소원자，중수소원자, C1내지 C6 알킬기또는， C1내지 C6히드록시알킬기이고 , η은반복단위이고.상기화학식 2로표시되는화합물의수평균분자량이 1,000내지 9,000,000이다.
[128] 여기서 C1내지 C6알킬기는바람직하게는ᅳ CH3일수있고， C1내지 C6 히드록시알킬기는바람직하게는ᅳ CH2-CHOH-CH3일수있다.
[129] 단계 (a)이후에조성물을 50내지 100°C의온도로유지하는단계 (a-1)을추가로 포함할수있다.단계 (a- 1)은바람직하게는 55내지 95°C,더욱바람직하게는 60 내지 90°C에서수행될수있다.
[130] 상기온도범위에서상기조성물의성분들이고르게섞일수있다.
[131] 단계 (a-1)은바람직하게는 2내지 6시간동안수행될수있으나단계 (a-1)의 온도에따라달라질수있다.또한,단계 (a-1)은진공하에서탈포하는단계를 추가로포함할수있다.
[132] 상기단계 (a-1)이후에상기조성물올 50내지 65°C의온도로유지하는단계 (a-2)를추가로포함할수있다.단계 (a-2)는바람직하게는 53내지 62°C,더욱 바람직하게는 54내지 60°C에서수행될수있다.
[133] 다음으로，와이어를준비하고，상기와이어의표면에상기조성물을코팅하여 조성물이코팅된와이어를제조한다 (단계 b).
[134] 상기단계 (b)의코팅은바람직하게는상기조성물의겔화온도에따라달라질 수있다.겔화온도가낮은물질의경우상기조성물은겔화온도이상에서상기 와이어에균일하게코팅될수있으며，겔화온도가높은물질의 경우상기 조성물은겔화온도이하에서상기와이어에균일하게코팅될수있다.예를 들어젤라틴은낮은온도에서겔화되므로겔화온도이상에서코팅을하는것이 바람직하고， HPMC는높은온도에서겔화되기때문에겔화온도보다낮은 온도에서코팅하는것이바람직하다.
[135] 상기치열교정부재는류브형，증공다각기등형,깔때기형,중공원뿔대형또는 중공다각뿔대형일수있다.
[136] 다음으로，상기조성물로코팅된와이어에서상기조성물을건조시켜,상기 와이어및상기와이어를중공에포함하는치열교정부재를제조한다 (단계 c).
[137] 상기단계 (c)는바람직하게는 25내지 30°C,상대습도 20내지 40%에서수행될 수있으나이에한정되는것은아니다.단계 (C)는상기조성물이평형상태에 도달할때까지수행할수있으며，상기조건에서수행될경우 12내지 72시간 동안수행될수있다.
[138] 단계 (c)에서상기조성물은고체에가까운겔 (gel)로굳어질수있다.상기
치열교정부재는치아교정시술에적용하였을때치아의배열상태에적합할수 있도록교정용와이어의구부러짐에도파손되지'않는유연성을가지면서 중공을유지하는정도의강도를갖는것이바람직하다.
[139] 마지막으로，상기중공에와이어를결합한치열교정부재로부터상기와이어를 제거하여치열교정부재를제조한다 (단계 d).
[140] 단계 d이후에，상기치열교정부재의표면에오일을처리하는단계를추가로 포함할수있다 (단계 d-l).
[141] 상기오일은미네랄오일,실리콘오일，식물성오일등이가능하다.
[142] 한편,시술자가시술을용이하게수행하기위하여치열교정부재에와이어를 삽입하여제공할수있다.
발명의실시를위한형태
[143] [실시예]
[144] 이하,본발명의바람직한실시예를들어설명하도록한다.그러나이는예시를 위한것으로서이에의하여본발명의범위가한정되는것은아니다.
[145] 제조예 1 :코팅용액의제조
[146] 430중량부의젤라틴 (젤텍사， 250 bloom)을 390중량부의물에분산시킨후, 140 중량부의글리세린을넣고혼합하였다.이후물에용해시킨솔비톨용액 (70% 농도) 5중량부를넣고고르게분산시켰다.다음으로, 60분간 90oC에서젤라틴 용해과정을거친후 30분동안 65°C에서 700mmHg진공으로탈포하였다.상기 탈포된용액올 60°C에서 6시간동안에이징 (aging)시켜코팅용액을제조하였다.
[147] 제조예 2:코팅용액의체조
[148] 2중량 %수용액의점도가 6 mPa.s인하이드록시프로필메틸
셀를로오스 (HPMC)를이용하여코팅용액을제조하였다.정제수 585중량부와 소르빈산칼륨 1중량부를넣어혼합한후,용액의온도를 90°C까지가열시켰다. 90°C의용액에 HPMC 220중량부와에탄올 194중량부를투입하여 2시간동안 혼합하여 HPMC를용해시켰다.상기제조된조성물을 55°C에서 12시간동안 숙성시켜치열교정부재용코팅조성물을제조하였다.
[149] 제조예 3:수용성튜브의제조
[150] 제조예 1에따라제조된코팅용액을 45°C로유지되어있는담지액통에넣는다. 길이 100mm, 0.5mm직경의스테인리스강 (stainless steel)직선형와이어를 고정나사로고정하고,상기와이어를파라핀으로코팅하였다.상기와이어를 코팅용액에담지한후바로빼내어코팅용액을균일하게코팅하였다.이후, 상온에서상대습도 25%， 24시간동안건조한후상기와이어를제거하여 치열교정부재를제조하였다.
[151] 체조예 4:수용성튜브의제조
[152] 제조예 2에따라제조된코팅용액을 20oC로유지되어있는담지액통에넣었다. 길이 100mm, 0.5mm직경의와이어를고정나사로고정하고,상기와이어를 파라핀으로코팅하였다.상기와이어를코팅용액에담지한후바로빼내어 코팅용액을균일하게코팅하였다.도 3과 4를참조하면，이후,상온에서 상대습도 25%, 24시간동안건조한후코팅부에식용색소를사용하여백색의 중심마크,작업마크및끝단마크를표시하고와이어를제거하여백색마크가 표시된치열교정부재를제조하였다.
[153] 심시예 1:와이어름 ¾합하치염교정복합체의제조
[154] 제조예 3의치열교정부재에와이어를삽입하여와이어를결합한
치열교정복합체를제조하였다.
[155] 심시예 2:와이어를 ¾함하치염교정복합체의제조
[156] 도 5와도 6을참조하면，제조예 4의중심마크，작업마크및끝단마크가표시된 치열교정부재에중심선이표시된와이어를삽입하고중심선과중심마크를 일치시켜와이어를결합한치열교정복합체를제조하였다.
[157]
[158] [시험예]
[159]
[160] ¾상시험예 1：치염교정복합체름이용하치염교정
[161] 실시예 1에따라제조된치열교정복합체를이용한치열교정의임상시험
과정을도 7에나타내었고，정면과측면사진을도 8에나타내었다.
[162] 도 7및도 8을참조하면，제조예 3에따라제조된수용성튜브에구강외에서 니켈-티타늄와이어를삽입하고，와이어가삽입된류브를직접치아에 접착하였다.그결과,구치부에서도웅용이가능한것으로나타났다.
[163] 따라서,실시예 1에따라제조된수용성류브가적용된치아교정복합체는
단순한구조로심미적이며,장치에의한연조직자극이없어편안하고，쉽게 구강위생을유지할수있는것을알수있었다.
[164]
[165] ¾상시험예 2:치염교정복함체름이^하치염교정
[166] 실시예 2에따라치열교정부재의중공에와이어를관통시켜결합한와이어를 결합한치열교정복합체를적용한치열교정의임상시험과정을도 9에나타냈고， 치열교정복합체를적용한치열의정면과측면사진을도 10에나타냈고， 나타내었다.
[167] 도 9및 10을참조하면，실시예 1및 3에따라제조된치열교정복합체를직접 치아에접착하였다.그결과,구치부에서도웅용이가능한것으로나타났다.
[168] 따라서，실시예 2에따라제조된와이어와결합된치열교정복합체는단순한 구조로심미적이며，장치에의한연조직자극이없어편안하며 ,쉽게구강위생을 유지할수있음올알수있었다.
[169]
[170] 상비교시 예 1 :종래의브라 1을이용하치염교정
[171] 도 2는본발명의수용성튜브형치열교정부재에와이어를삽입한
치열교정복합체와종래의브라켓또는소형중공관의측단면을개략적으로 나타낸것이고，도 11은종래의브라켓을이용한치열교정의결과를나타낸 것이다.
[172] 도 2및도 11올참조하면，종래의브라켓을치아에접착한후결속타이를
이용하여와이어가브라켓에서빠지지않도록결속하였다.그결과，크고복잡한 구조를지닌브라켓과그부속물은구강내연조직을자극하는것으로나타났다.
[173] 따라서,종래의브라켓은복잡한구조로심미적이지않고,구강내연조직을 자극하며구강위생유지를어렵게하는것을알수있었다.
[174]
[175] ¾상비교시 예 2:중공과형태의류브름이용하치염교정
[176] 종래의중공관형태의류브를이용한치열교정의사진을도 12에나타내었다.
[177] 도 2및도 12를참조하면,종래의중공관형태의튜브를치아에접착한후
와이어를순차적으로통과하도록삽입하였다.그결과,목뒤에서부터와이어를 끼우는것은근본적으로불가능하기때문에，전치부에한정된부분교정 치료에만응용할수있는것으로나타났다:
[178] 따라서,중공관형태의튜브는전치부에한정된부분교정치료에만적용할수 있고，와이어삽입에많은시간이소요되는것을알수있었다.
[179]
[180] 본발명의범위는상기상세한설명보다는후술하는특허청구범위에의하여 나타내어지며，특허청구범위의의미및범위그리고그균둥 7fl념으로부터 도출되는모든변경또는변형된형태가본발명의범위에포함되는것으로 해석되어야한다.
산업상이용가능성
[181] 본발명은수용성또는생분해성물질을포함하는중공형치열교정부재및 상기중공에위치하는와이어를포함하는치열교정복합체를제공할수있다.
[182] 본발명은접착제를사용하여치아표면에접착하기쉬우며，간편하게치아 교정시술을할수있는치열교정복합체를제공할수있다ᅳ
[183] 본발명은치열교정시술시소정기간후용해되거나생분해되어와이어와 접착제사이에간극을형성함으로써，치아가와이어를따라미끄러지면서 이동할수있도록하여치아이동이용이한치열교정복합체를제공할수있다.
[184] 본발명은상기치열교정복합체의제조방법을제공할수있다.
[185]

Claims

청구범위
[청구항 1] 튜브 (tube)형，중공다각기등형,중공다각뿔대형,중공원뿔대형또는 깔때기 (funnel)형의치열교정부재;및
상기치열교정부재의증공에 치열교정용와이어를포함하는 치열교정복합체이고,
상기치열교정부재는수용성또는생분해성물질을포함하는 치열교정복합체.
[청구항 2] 제 1항에 있어서，
상기튜브형치열교정부재는내경이 0.2내지 1.0 mm이고，두께가으 001 내지 0.5 mm인것을특징으로하는치열교정복합체.
[청구항 3] 제 1항에 있어서，
상기중공다각기등형은 n각기등형이고, n은 3내지 20의 정수중어느 하나인것을특징으로하는치열교정복합체.
[청구항 4] 제 3항에 있어서,
상기중공다각기등형치열교정부재의단면이중공의다각형이고， 상기중공의다각형에내접하는원의직경은 0.2내지 1.0 mm이고, 상기중공다각기등형 치열교정부재의두께는 0.001내지 0.5 mm인것을 특징으로하는치열교정복합체.
[청구항 5] 제 1항에 있어서，
상기증공다각뿔대형이중공의 n각뿔대형이고 , η은 3내지 20의 정수중 어느하나인것을특징으로하는치열교정복합체 .
[청구항 6] 제 5항에 있어서，
상기중공다각뿔대형치열교정부재의단면이증공의 다각형아고， 상기중공의다각형에외접하는원의최대직경 (F)대비 최소직경 (f 의 비 (F/f, p)가 1<ρ≤10인것을특징으로하는치열교정복합체 .
[청구항 7] 제 1항에 있어서，
상기중공원뿔대형치열교정부재의최대내주의직경 (E)대비 최소 내주의직경 (e)의 비 (E/e, q)가 l<q≤10인것을특징으로하는 치열교정복합체.
[청구항 8] 게 1항에 있어서,
상기깔때기형의치열교정부재가중공형원기등의 일단부에 결합된 증공형원뿔대를포함하는형태인것을특징으로하는치열교정복합체.
[청구항 9] 제 8항에 있어서,
상기깔때기형의치열교정부재는상기증공형원뿔대의최대내주의 직경 (D)대비상기중공형원기등의내주의직경 (d)의 비 (D/d, r)가 Kr<10 인것을특징으로하는치열교정복합체 .
[청구항 1이 제 1항에 있어서, 상기치열교정부재는색상이투명하거나또는백색,적색，청색,황색， 녹색및이들의흔합색으로이루어진군에서선택된어느하나인것을 특징으로하는치열교정복합체.
[청구항 11] 제 1항에있어서,
상기치열교정부재는마크가표시된것을특징으로하는
치열교정복합체.
[청구항 I2] 제 11항에있어서,
상기마크가상기치열교정부재의길이방향을기준으로중심부를 표시하는중심마크，상기중심부로부터의길이를표시하는작업마크， 끝단을표시하는끝단마크중 1종이상을포함하는것을특징으로하는 치열교정복합체.
[청구항 13] 제 12항에있어서，
상기중심마크가상기치열교정부재의내경또는외경의크기에따라 소정의색상으로표시된것을특징으로하는치열교정복합체.
[청구항 14] 제 13항에있어서,
상기중심마크는두께가 0.1내지 5mm인것을특징으로하는 치열교정복합체.
[청구항 15] 제 13항에있어서,
상기색상은백색，적색，청색,황색，녹색및이들의혼합색으로이루어진 군에서선택된어느하나인것을특징으로하는치열교정복합체.
[청구항 16] 제 1항에있어서,상기수용성또는생분해성물질이
젤라틴,전분,전분유도체，샐를로오스，셀를로오스유도체，식물성검， 아가，알긴，알긴산염，카라기난，키토산,키토산유도체，펙틴,덱스트란, 히알루로닉에시드，폴리아크릴아미드,폴리비닐피롤리돈, 폴리비닐알코올,폴리아크릴릭에시드，폴리에틸렌글라이콜,
폴리프로필렌글라이콜，폴리에틸렌옥사이드,폴리프로필렌옥사이드， 생분해성폴리아미드,생분해성폴리우레탄및생분해성폴리에스터 중에서선택된 1종이상을포함하는것을특징으로하는치열교정복합체.
[청구항 17] 제 16항에있어서,상기수용성또는생분해성물질이
상기젤라틴,전분,전분유도체，샐를로오스，셀를로오스유도체,식물성 검,아가,알긴，알긴산염，카라기난，키토산,키토산유도체，펙틴， 덱스트란,히알루로닉에시드,폴리아크릴아미드，폴리비닐피롤리돈, 폴리비닐알코을，폴리아크릴릭에시드,폴리에틸렌글라이콜，
폴리프로필렌글라이콜,폴리에틸렌옥사이드，을리프로필렌옥사이드, 생분해성폴리아미드,생분해성폴리우레탄및생분해성폴리에스터 중에서선택된 1종이상 100증량부에대하여，아래화학식 i로표시되는 화합물 1내지 200중량부를추가로포함하는것을특징으로하는 치열교정복합체. [화학식 1]
Figure imgf000019_0001
상기화학식 1에서
n은 1내지 8의정수중어느하나이다.
[청구항 18] 제 1항에있어서,
상기수용성또는생분해성물질이아래화학식 2로표시되는화합물을 포함하는것을특징으로하는치열교정복합체.
[
Figure imgf000019_0002
상기화학식 2에서
R은각각독립적으로수소원자，증수소원자, C1내지 C6알킬기또는, C1 내지 C6히드록시알킬기이고，
n은반복단위이고.
상기화학식 2로표시되는화합물의수평균분자량이 1,000내지
9,000,000이다.
[청구항 19] 물을포함하는용매및수용성또는생분해성물질을포함하는
치열교정부재용조성물을준비하는단계；
상기조성물을제 1와이어에코팅하는단계;및
상기조성물이코팅된제 1와이어를건조하여수용성또는생분해성 물질이코팅된제 1와이어를제조하는단계;를
포함하는치열교정복합체의제조방법 . 청구항 20] 제 19항에 있어서，치열교정복합체의제조방법이
상기수용성또는생분해성물질이코팅된제 1와이어를제조하는단계 후에
상기수용성또는생분해성물질이코팅된제 1와이어에서상기거 U 와이어를제거하여중공을갖는치열교정부재를제조하는단계;및 저 12와이어를상기치열교정부재의중공에삽입하여치열교정복합체를 제조하는단계;를추가로포함하는것을특징으로하는
치열교정복합체의제조방법.
PCT/KR2016/005055 2015-07-16 2016-05-13 치열교정복합체 및 그의 제조방법 WO2017010668A1 (ko)

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EP3332732A1 (en) 2018-06-13
EP3332732A4 (en) 2019-03-20
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US11291528B2 (en) 2022-04-05
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