WO2016159423A1 - 포졸란을 포함하는 가축 사료용 첨가제 조성물 및 이의 용도 - Google Patents

포졸란을 포함하는 가축 사료용 첨가제 조성물 및 이의 용도 Download PDF

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WO2016159423A1
WO2016159423A1 PCT/KR2015/003416 KR2015003416W WO2016159423A1 WO 2016159423 A1 WO2016159423 A1 WO 2016159423A1 KR 2015003416 W KR2015003416 W KR 2015003416W WO 2016159423 A1 WO2016159423 A1 WO 2016159423A1
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livestock
composition
pozzolanic
feed
weight
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PCT/KR2015/003416
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English (en)
French (fr)
Korean (ko)
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최규택
박병성
박상오
이관호
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주식회사 모닝스타
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Priority to CN201580078379.0A priority Critical patent/CN107427030A/zh
Publication of WO2016159423A1 publication Critical patent/WO2016159423A1/ko

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  • the present invention relates to an additive composition for livestock feed and its use comprising Pozzolan as an active ingredient.
  • Organic livestock refers to livestock that has not been fertilized or genetically modified for livestock production without chemical fertilizers, pesticides, and genetically modified feeds.
  • antibiotics, growth hormone, and animal origin It is not an intensive factory-type breeding that does not use artificial synthetic additives such as by-product feeds or animal medicines, but it is a natural method of breeding, processing, Means the distribution, evaluation, and labeling of livestock and their livestock products.
  • the certification of organic livestock includes the production and distribution of organic livestock as well as the final product, the livestock food.
  • the most difficult part of implementing organic livestock is the coping and prevention of diseases when breeding without antibiotics. This requires the administration of feed additives with immunity and antimicrobial / antiviral activity.
  • the certification criteria for organic livestock raising in Korea is the transition period (12 months after stocking of cattle, 6 months after pigs). Use only acceptable substances and do not use antibiotics or growth accelerators. According to the Ministry of Agriculture, Forestry and Forestry Notice No. 2004-72, it was limited to 18 species (9 anticoccidial agents, 9 growth promoters) from December 2007. In 2012, the use of antibiotics as a growth accelerator for livestock is completely prohibited.
  • the inventors of the present invention can replace antibiotics and provide an antimicrobial composition for feed, and in particular, it is possible to suppress harmful bacteria and improve immune function for livestock feed, and to improve feed demand and feed for livestock feed. It is an object to provide an antimicrobial composition of a new material. It is also an object of the present invention to provide a feed additive, a livestock feed comprising the same, and a novel immune enhancing method.
  • the present invention provides an antimicrobial composition for livestock feed comprising pozzolan as an active ingredient.
  • the pozzolanic may be a combination of any one or more of silica, aluminum, aluminum oxide (Al 2 O 3), iron, (Fe), ferric trioxide (Fe 2 O 3), and germanium (Ge).
  • the pozzolane is a composition having a silica content of at least 70% by weight.
  • the pozzolane is a composition in which the content ratio of silicon and silicon dioxide (SiO 2) in silica is in the range of 1: 2 to 1: 3.
  • the pozzolan may be 80% by weight or more of silica and aluminum oxide. It is preferred to be in the powder phase in the pozzolane.
  • the pozzolanic is preferably mixed in a ratio of 0.01 to 0.70% by weight based on the total weight of the feed.
  • the livestock may be any one of cows, chickens, pigs, horses, goats, ducks, geese, dogs, cats, and rabbits.
  • a livestock feed additive containing the antimicrobial composition as an active ingredient.
  • the pozzolanic is preferably mixed in a ratio of 0.01 to 0.70% by weight based on the total weight of the feed, the livestock may be any one of cow, chicken, pig, horse, goat, duck, goose, dog, cat, rabbit. have.
  • a livestock feed comprising the livestock feed additive.
  • a method for enhancing immunity of a livestock wherein the antimicrobial composition or the livestock feed additive is administered to a livestock.
  • Pozolan for livestock feed according to the present invention is a very suitable material for feed of organic livestock, such as odor removal while enhancing the immune function and have an antimicrobial / antiviral effect. It improves the absorption and utilization of nutrients and has a weight gain effect, which in turn can improve meat quality and promote growth. Livestock It can be applied to a variety of livestock feed, and can replace antibiotics with various side effects, so it is expected to satisfy the strict specifications of countries around the world including Korea.
  • 1 to 4 are photographs showing the growth inhibitory or promoting effect of each of the strains Salmonella typhimurium, Escherichia coli, Clostridium butyricum, Lactobacillus casei.
  • Control group (medium 1), SP extract (medium 4), SP3% (medium 2), SP5% (medium 3) is shown.
  • FIGS 6 and 7 are photographs showing growth inhibition of strains MRSA (Staphylococcus aureus) and VRE (Enterococcus), respectively.
  • Figure 8 is a graph comparing the growth of the strains (MRSA and VRE). Control group (medium 1), SP extract (medium 4), SP3% (medium 2), SP5% (medium 3) is shown.
  • FIG. 9 is a graph comparing the 35-day shipping weight of the broiler of Example 3.
  • Figure 10 is a graph comparing the weight gain rate by growth period of the broiler of Example 3.
  • Figure 11 is a graph comparing the feed efficiency of the broiler of Example 3.
  • Control group (T1), SP 0.3% (T2), SP 0.5% (T3), SP 0.7% (T4) are shown.
  • FIG. 12 is a graph comparing the conductor ratio of the broiler of Example 3.
  • FIG. 13 is a graph comparing tracheal weight at week 3 of the broiler of Example 3.
  • FIG. 14 is a graph comparing tracheal weight at week 5 of the broiler of Example 3.
  • FIG. 15 is a graph comparing the weight of immune organs of the broiler of Example 3 at week 3.
  • FIG. 15 is a graph comparing the weight of immune organs of the broiler of Example 3 at week 3.
  • FIG. 16 is a graph comparing the weight of immune organs of the broiler of Example 3 at week 5.
  • FIG. 17 is a graph comparing blood IgG content of broilers of Example 3.
  • FIG. 18 is a graph comparing the concentration of powdered microorganisms in a broiler of Example 3.
  • 19 and 20 are graphs comparing the contents of cecum organic acid of the broiler of Example 3.
  • Control group (T1), SP 0.3% (T2), SP 0.5% (T3), SP 0.7% (T4) are shown.
  • 21 is a graph comparing fatty acid content of broiler of Example 3.
  • Figure 23 is a graph comparing the hydrogen sulfide content of the broiler of Example 3.
  • FIG. 24 is a graph comparing end weights of piglets of Example 4.
  • 25 is a graph comparing the daily weight gain of piglets of Example 4.
  • Figure 26 is a graph comparing the daily feed intake of piglets of Example 4.
  • Figure 27 is a graph comparing the feed demand rate of piglets of Example 4.
  • FIG. 28 is a graph comparing blood analysis results of piglets of Example 4.
  • FIG. 29 is a graph comparing the concentration of powdered microorganisms in piglets of Example 4.
  • 30 and 31 are graphs comparing the contents of cecum organic acid in piglets of Example 4.
  • the present invention provides an antimicrobial composition for livestock feed comprising pozzolan as an active ingredient.
  • the pozzolan mineral is composed of volcanic ashes and is known as a type of feldspar. It is known as an orphan created during the Cretaceous period, and its main mountain is a mineral derived from Pojori village near Bari Island in Italy, and the famous Colosseum Stadium, which was already famous in Roman times around 2nd century AD, and Pandeon. It has been found by researchers to use pozzolanic, which has been used in place of cement in buildings and has been preserved in its original form for years without cracking and corrosion. Other distribution areas are produced only in extremely limited regional countries such as the United States, the Mountain Region, Malaysia, and India, and the unusual ones are the fact that there is no germanium or far-infrared emission effect other than Italy and Korea. The same vein does not exist at all.
  • pozzolan was added to the base material of concrete manufacturing and used as a mixed material to give special performance to concrete or to improve its properties.
  • Inorganic solidifying material for solidifying waste is usually cement-reactive, so that inorganic sludge of appropriate moisture content Suitable for solidifying (containing heavy metals).
  • pozzolan (Pozzolan) having a good affinity with cement is most commonly used to control the sludge moisture content and cement replacement solidification aid, and the cost is relatively low.
  • Pozzolanic is at least one selected from the group consisting of volcanic ash, tuff, siliceous silica, diatomaceous earth and natural rock, and is preferably in powder form.
  • the main component may be silica-alumina or silica, and preferably pozzolan is a combination of any one or more of silica, aluminum, aluminum oxide (Al 2 O 3), iron, (Fe), ferric trioxide (Fe 2 O 3), and germanium (Ge).
  • pozzolanic is a composition having a silica content of at least 70% by weight.
  • the pozzolane is a composition in which the content ratio of silicon and silicon dioxide (SiO 2) in silica is in the range of 1: 2 to 1: 3.
  • the pozzolane preferably has a content of silica and aluminum oxide of 80% by weight or more. It is preferred to be in the powder phase in the pozzolane.
  • antimicrobial is meant the ability to reduce, prevent, inhibit or eliminate the growth or survival of microorganisms at any concentration.
  • the antimicrobial composition may mean the same as an antibiotic, which is a generic term for an antimicrobial agent, and may mean the same as an antimicrobial agent, a fungicide, a preservative, a preservative or an antimicrobial agent, preferably Gram-positive bacteria, Gram-negative bacteria, fungi (yeast and mold) Means a substance capable of inhibiting or inhibiting the development and life functions of at least one microorganism selected from the group consisting of, that is, antibacterial and antifungal substances.
  • the pozzolanic may be added to the feed without content limitation, but is preferably mixed in a ratio of 0.01 to 0.70% by weight based on the total weight of the feed. More preferably, it is 0.3 to 0.7 weight%, More preferably, it is 0.5 weight%.
  • the livestock may be cattle, chickens, pigs, horses, goats, ducks, geese, dogs, cats or rabbits, preferably chicken or pigs, but is not limited thereto.
  • a livestock feed additive containing the antimicrobial composition as an active ingredient.
  • the livestock feed additive may be used as it is or may be added to known carriers, stabilizers, etc., such as grains and by-products allowed for livestock, and organic acids such as citric acid, fumaric acid, adipic acid, lactic acid, and malic acid, if necessary.
  • Phosphates such as sodium phosphate, potassium phosphate, acid pyrophosphate, and polyphosphate (polyphosphate), or natural substances such as polyphenols, catechins, alpha-tocopherols, rosemary extracts, vitamin C, green tea extracts, licorice extracts, chitosan, tannic acid, and phytic acid.
  • Antioxidants, antibiotics, antibacterial agents and other additives may be added, and the shape thereof may be in a suitable state such as powder, granules, pellets, suspensions, etc. It can be mixed and supplied to.
  • the pozzolanic is preferably mixed in a ratio of 0.01 to 0.70% by weight based on the total weight of the feed, the livestock may be any one of cow, chicken, pig, horse, goat, duck, goose, dog, cat, rabbit. have.
  • a livestock feed comprising the livestock feed additive.
  • the additives may be cereals, for example crushed or ground wheat, oats, barley, corn and rice; Vegetable protein sources based on rapeseed, soybean and sunflower seeds; Animal protein sources; molasses; And dry ingredients consisting of milk products such as various milk powders and whey powders.
  • the liquid component may consist of lipids, such as fats, for example vegetable fats, and / or carboxylic acids, for example fatty acids, optionally liquefied by heating.
  • a powder or particulate concentration is obtained depending on the degree of polishing of the components.
  • water should preferably be added to the animal feed, which is subsequently processed by conventional pelletization, extension or extrusion processes. Any additional water can be removed by drying. If desired, the resulting particulate animal feed can be ground to smaller particle sizes.
  • a method for enhancing immunity of a livestock wherein the antimicrobial composition or the livestock feed additive is administered to a livestock.
  • the pozzolane is mixed at a ratio of 0.01 to 0.70% by weight based on the total weight of the feed, more preferably 0.3 to 0.7% by weight, even more preferably 0.5% by weight.
  • the livestock may be cattle, chickens, pigs, horses, goats, ducks, geese, dogs, cats or rabbits, preferably pigs, but is not limited thereto.
  • Pozzolane was supplied with powdered products from Morningstar Co., Ltd. and analyzed by ingredients of KIST's analysis institute, and as a result, various Si and Ge components were identified as shown in Tables 1 and 2 below. It became.
  • a sample was prepared by mixing various amounts of pozzolanic or pozzolanic extract in a raw material medium or feed.
  • Distilled water medium 1 which is a control group, was sterilized after adding distilled water to the raw material of the medium without adding pozzolan, diluted with strain 10 ⁇ 7 , and then inoculated with 100 uL.
  • Distilled water medium 2 and 3 of the experimental group were mixed with 3.0 and 5.0% of distilled water and pozzolane, respectively, and sterilized in the raw material, and diluted with strain 10 ⁇ 7 , respectively, and then inoculated with 100 uL.
  • CFU Coldy Forming Unit
  • colony mass, colony
  • FIGS. 1 to 4 and 6 to 7 Photos showing growth inhibition or promotion according to the media of the respective strains are shown in FIGS. 1 to 4 and 6 to 7, respectively. Comparison graphs between the strains are shown in FIGS. 5 and 8.
  • beneficial bacteria Salmonella typhimurium, Escherichia coli, MRSA, VRE
  • pozzolanic or pozzolanic extract The effect was confirmed.
  • broiler broiler broiler broiler
  • the growth capacity of each stage according to the growth of broiler that is, feed intake, weight gain and feed efficiency, were measured, respectively, and the results are shown in Table 7 below. Feed efficiency was expressed as feed intake divided by weight gain in a given period. The dressing percent was calculated as the ratio of carcass weight (weight excluding feathers, blood, head, legs and viscera) to live weight at day 35. The results are shown in Table 8 below. The weights of liver, proximal and immune organs (thymus, spleen, F sac) were measured at 3 weeks and 5 weeks, respectively. Table 10 is the analysis of lipids, blood sugar, AST, ALT, and the like through blood analysis.
  • FIG. 9 is a graph comparing the 35-day shipping body weight according to the pozzolanic content showed the largest increase rate in the case of 0.5% content of pozzolanic T3.
  • Figure 10 is a comparison of the weight gain rate by growth period, the highest increase rate of pozzolanic 0.5% content at each time period.
  • FIG. 11 shows a comparison of feed efficiency, and showed similar results for pozolan 0.3% and 0.7%, and slightly increased for 0.5% T3.
  • FIG. 12 shows a somewhat higher increase in T3, comparing the conductor rates.
  • FIG. 13 is a graph comparing the increase in tracheal weight at 3 weeks, the largest increase in T3 followed by the highest increase in the order of T2 and T4.
  • Figure 14 is a graph comparing the increase in tracheal weight at 5 weeks, which also showed a slightly higher increase in T3, and the other T2 and T3 were similar to the control group T1.
  • Figure 15 shows the weight of the immune system at 3 weeks, showing a significant increase in T3 indirectly showing that the duration of immunity is enhanced.
  • Figure 16 shows the weight of the immune organs at week 5, which also showed a markedly high increase in T3.
  • Blood immunoassay was determined by ELISA (enzyme-linked immunosorbent assay, Bethyl laboratories., Inc., USA) (Constantinoiu et al., 2007). The results are shown in Table 11.
  • Figure 17 is a graph comparing the content of IgG as a blood immune material showed the largest increase in T3 and in order of T4 and T2 confirmed that the pozzolanic can increase the secretion of immune material.
  • Fig. 18 is a graph comparing the change patterns of the microorganisms, and the beneficial bacteria showed the highest concentration in T3 for Lactobacillus , and the high inhibitory effect for the harmful bacterium E. Coli, Salmonella .
  • the cecals were collected from the sacrificed chickens and the concentrations of acetate, propionate, butyrate, isobutyrate, valerate and isovalerate were measured by a gas chromatographic system (model GC-15A, Shimadzu Corp., Kyoto, Japan). It was.
  • Figures 19 and 20 compare the cecum organic acid, although the content of some organic acids decreased, but the overall short-chain organic acid (SCFA, Sohrt chain Fatty acid) showed the largest increase rate in T3 and increased in the treatment group containing pozzolanic Showed.
  • SCFA Sohrt chain Fatty acid
  • Lipids were extracted from chicken leg meat and injected into a gas chromatographic system (model GC-15A, Shimadzu Corp., Kyoto, Japan) to analyze fatty acids. The results are shown in Table 14.
  • Ammonia and hydrogen sulfide concentrations were measured with a gas indicator (Gas Indicator AP-20, Axis Sensitive Co. Ltd, Japan). After inhaling the gas according to the manufacturer's manual, the displayed value was recorded and compared with the control, and presented as shown in Table 15 below.
  • a gas indicator Gas Indicator AP-20, Axis Sensitive Co. Ltd, Japan.
  • 22 and 23 are graphs comparing the contents of ammonia and hydrogen sulfide, showing a tendency to decrease overall in the treatment group containing pozzolanic, in particular, the largest decrease in T4.
  • 24 to 27 are graphs comparing end weight, daily weight gain, daily intake, and feed demand rate, respectively, showing a high increase rate in the treatment group containing pozzolanic, especially the highest value in the group containing 0.5% pozzolanic. Showed.
  • FIG. 28 is a graph comparing the levels of lipids and blood glucose as a result of blood analysis, showing an increase in the treatment group containing pozzolanic. This is higher than the antibiotic treatment group, demonstrating the replacement effect of antibiotics.
  • Blood immunoassay was measured by ELISA (enzyme-linked immunosorbent assay, Bethyl laboratories., Inc., USA) (Constantinoiu et al., 2007) and the results are shown in Table 18.
  • Fig. 29 is a graph comparing the microorganisms with beneficial bacteria showed the highest concentration in T3 in the case of Lactobacillus , and showed higher inhibitory effect than the antibiotics in the case of harmful bacterium E. Coli, Salmonella .
  • cecals were collected from sacrificial weaners and the concentrations of acetate, propionate, butyrate, isobutyrate, valerate and isovalerate were measured by a gas chromatographic system (model GC-15A, Shimadzu Corp., Kyoto, Japan) and the results are shown in Table 20. .
  • T4 group containing 0.5% of the total short chain organic acid (SCFA) containing pozzolanic showed a higher increase rate than the T2 group treated with antibiotics, and contained pozzolanic as a whole.
  • the treatment group showed a tendency to increase.
  • pozolan induced an increase in the organic acid of the cecum.

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PCT/KR2015/003416 2015-03-31 2015-04-06 포졸란을 포함하는 가축 사료용 첨가제 조성물 및 이의 용도 WO2016159423A1 (ko)

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KR101890877B1 (ko) * 2017-04-28 2018-08-23 (주)현농 바실러스 서브틸러스와 비타민b2를 함유한 양어용 보조사료와 이의 제조방법
KR102139867B1 (ko) * 2018-10-17 2020-07-29 주식회사 바이오원 고수율의 바다달팽이 펩타이드의 제조방법
KR102374291B1 (ko) * 2019-09-10 2022-03-14 강릉원주대학교산학협력단 천연 포졸란을 포함하는 사료 첨가제 조성물
KR102289532B1 (ko) * 2021-01-28 2021-08-17 농업회사법인 주식회사 삼광 기능성 가축보조사료의 조성물 및 이의 제조방법

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