WO2016153203A1 - Composition cosmétique pour parfaire l'éclaircissement de la peau - Google Patents
Composition cosmétique pour parfaire l'éclaircissement de la peau Download PDFInfo
- Publication number
- WO2016153203A1 WO2016153203A1 PCT/KR2016/002499 KR2016002499W WO2016153203A1 WO 2016153203 A1 WO2016153203 A1 WO 2016153203A1 KR 2016002499 W KR2016002499 W KR 2016002499W WO 2016153203 A1 WO2016153203 A1 WO 2016153203A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- skin whitening
- formula
- melanin
- cosmetic composition
- compound
- Prior art date
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 63
- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 239000002537 cosmetic Substances 0.000 title claims abstract description 35
- 230000000694 effects Effects 0.000 claims abstract description 19
- 235000013376 functional food Nutrition 0.000 claims abstract description 17
- 230000036541 health Effects 0.000 claims abstract description 13
- 230000005764 inhibitory process Effects 0.000 claims abstract description 10
- 230000003061 melanogenesis Effects 0.000 claims abstract description 5
- 210000003491 skin Anatomy 0.000 claims description 65
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims description 58
- 150000001875 compounds Chemical class 0.000 claims description 41
- 210000002752 melanocyte Anatomy 0.000 claims description 29
- 238000004519 manufacturing process Methods 0.000 claims description 27
- 230000015572 biosynthetic process Effects 0.000 claims description 25
- 230000002401 inhibitory effect Effects 0.000 claims description 23
- 210000004027 cell Anatomy 0.000 claims description 21
- 108010070503 PAR-2 Receptor Proteins 0.000 claims description 19
- 102000032628 PAR-2 Receptor Human genes 0.000 claims description 17
- 230000019612 pigmentation Effects 0.000 claims description 13
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims description 12
- 235000013305 food Nutrition 0.000 claims description 12
- 230000003796 beauty Effects 0.000 claims description 11
- 210000002510 keratinocyte Anatomy 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 7
- 210000001787 dendrite Anatomy 0.000 claims description 7
- 210000004443 dendritic cell Anatomy 0.000 claims description 7
- 230000001737 promoting effect Effects 0.000 claims description 6
- 230000002708 enhancing effect Effects 0.000 claims description 5
- 229960002986 dinoprostone Drugs 0.000 claims description 2
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 12
- -1 PGE 2 Chemical compound 0.000 description 10
- 230000008099 melanin synthesis Effects 0.000 description 10
- 239000000284 extract Substances 0.000 description 7
- 239000003075 phytoestrogen Substances 0.000 description 7
- HOWDUIVVWDUEED-WAUHAFJUSA-N Ser-Leu-Ile-Gly-Lys-Val-Amide Chemical compound OC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O HOWDUIVVWDUEED-WAUHAFJUSA-N 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 239000000262 estrogen Substances 0.000 description 4
- 229940011871 estrogen Drugs 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 4
- 229960004705 kojic acid Drugs 0.000 description 4
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 102000003425 Tyrosinase Human genes 0.000 description 3
- 108060008724 Tyrosinase Proteins 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241000935061 Larrea Species 0.000 description 2
- 241001547668 Larrea cuneifolia Species 0.000 description 2
- 244000122992 Larrea divaricata Species 0.000 description 2
- 102000018402 Protease-activated receptor 2 Human genes 0.000 description 2
- 229930185210 Saponoside Natural products 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- 238000003501 co-culture Methods 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000000411 inducer Substances 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- CNOKQOBEMGIIAH-JYAZKYGWSA-N (2s)-2-[[(2s)-2-[[2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoic acid Chemical compound OC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(O)=O CNOKQOBEMGIIAH-JYAZKYGWSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 244000014603 Kigelia pinnata Species 0.000 description 1
- 235000002329 Kigelia pinnata Nutrition 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 241000159213 Zygophyllaceae Species 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 235000015140 cultured milk Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 229940124600 folk medicine Drugs 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000008269 hand cream Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical class C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical class OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000012035 limiting reagent Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 238000007539 photo-oxidation reaction Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 108010014211 seryl-leucyl-isoleucyl-glycyl-arginyl-leucine Proteins 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
Definitions
- the present invention relates to a cosmetic composition for enhancing skin lightening.
- Human skin color is determined by a number of factors, including the activity of melanocytes (melanocytes) that make melanin pigments, the distribution of blood vessels, the thickness of the skin and the presence or absence of pigments in the body, such as carotenoids or bilirubin.
- melanocytes melanocytes
- the black pigment called melanin produced in melanocytes has the most important effect on the skin color of humans.
- the formation of melanin pigment is influenced by genetic factors, physiological factors related to hormone secretion and stress, and environmental factors such as ultraviolet irradiation.
- Melanin has an important function of protecting the body from ultraviolet rays due to its presence in the skin, but overproduction of melanin cures or alleviates excessive melanin pigmentation caused by skin pigment abnormalities such as blemishes, freckles or pigmentation and UV exposure. Research into functional cosmetics for the purpose of whitening improvement is being actively conducted.
- Kojic acid has been used in cosmetics and pharmaceuticals as a representative raw material with a whitening effect, but it has been discontinued due to insufficient whitening effect of kojic acid, safety problems on the skin, formulation and stability during formulation, etc. There is a growing demand for new raw materials that can be used as alternatives to kojic acid.
- the present inventors have completed the present invention to provide a cosmetic composition for enhancing skin whitening by inhibiting the increase of prostaglandin E 2 (PGE 2 ), which is an intermediate factor promoting the production of melanin, by inhibiting melanin production.
- PGE 2 prostaglandin E 2
- An object of the present invention is to provide a cosmetic composition for skin whitening enhancement.
- An object of the present invention is to provide a cosmetic composition for enhancing skin whitening through the inhibition of intermediate factors that promote the production of melanin.
- An object of the present invention is to provide a health functional food for skin whitening improvement.
- the present invention provides a cosmetic composition for improving skin whitening containing a compound represented by the following formula (1) as an active ingredient.
- the compound of the present invention may provide a cosmetic composition for enhancing skin whitening, which is characterized by inhibiting skin melanin production by inhibiting PGE 2 (Prostaglandin E 2 ) activity, but is not limited thereto.
- a cosmetic composition for enhancing skin whitening which is characterized by inhibiting skin melanin production by inhibiting PGE 2 (Prostaglandin E 2 ) activity, but is not limited thereto.
- the compound of the present invention is characterized by inhibiting dendritic cell formation (DC formation) of melanocytes by proteinase-activated receptor-2 (PAR-2). It may provide a cosmetic composition for improving skin whitening, but is not limited thereto.
- the compound may illustrate a cosmetic composition for improving skin whitening, which is contained in an amount of 0.001 to 10% by weight based on the total weight of the composition, but is not limited thereto.
- the present invention provides a method of inhibiting melanin pigmentation by inhibiting the increase of PGE 2 (Prostaglandin E 2 ) by treating a compound represented by Formula 1 to keratinocytes and melanogenesis cells.
- PGE 2 Prostaglandin E 2
- the present invention is a dendritic cell of melanocytes (Melanocyte) by the protease-activated receptor-2 (PAR-2) by treating the compound represented by the formula (1) to keratinocytes and melanogenesis cells It provides a method of suppressing formation (DC formation).
- the present invention provides a health functional food for improving skin whitening containing the compound represented by the following formula (1) as an active ingredient.
- the health functional food may include, but is not limited to, a health functional food for improving skin whitening, which is an inner beauty food.
- the present invention is a cosmetic composition for skin whitening to enhance the skin whitening cosmetic composition having the effect of skin whitening by inhibiting the production of melanin by inhibiting the production of PGE 2 (Prostaglandin E 2 ) as an intermediate factor for promoting melanin production Can provide.
- PGE 2 Prostaglandin E 2
- the cosmetic composition for improving skin whitening according to the present invention, it is possible to provide a health functional food for improving skin whitening as well as cosmetics for improving skin whitening while having an excellent effect on improving skin whitening and having low cytotoxicity.
- the health functional food for improving skin whitening has an advantage of having an effect of improving skin whitening even more by ingesting it in the form of inner beauty food.
- prostaglandin E 2 Prostaglandin E 2, PGE 2.
- Figure 2 shows the results of inhibition of melanocyte dendrite cell formation (Melanocyte dendrite cell formation).
- the present invention provides a cosmetic composition for skin whitening, containing a compound represented by the following formula (1) as an active ingredient.
- the compound is known to be effective in anti-inflammatory, antibacterial, bactericidal action, and lowers blood pressure and is used for anti-inflammatory, such as sinusitis, headache, toothache, rhinitis.
- the present inventors completed the present invention to provide a cosmetic composition for improving skin whitening containing the compound as an active ingredient for the first time that the compound having such an anti-inflammatory effect has the effect of improving skin whitening.
- the compound may provide a cosmetic composition for skin whitening, which is characterized by preventing pigmentation by inhibiting skin melanin production by inhibiting PGE 2 (Prostaglandin E 2 ) activity, but is not limited thereto. .
- Inflammation-induced PGE 2 by protease-activated receptor-2 (PAR-2) in cells increases the dendrite length of surrounding melanocytes, leading to increased melanin delivery to surrounding cells. It becomes easy and pigmentation by melanin formation is increased.
- the present invention is a method for inhibiting pigmentation by inhibiting the production of intermediate factors that promote the production of melanin, such as PGE 2 , which is an inflammation-inducing substance, by using a compound represented by Chemical Formula 1 of the present invention. It provides a cosmetic composition for improving skin whitening by inhibiting the production of PGE 2 caused by the activity of the activating receptor (PAR-2) to inhibit melanin formation.
- PGE 2 which is an inflammation-inducing substance
- the inhibition of melanin formation prevents the production of PGE 2 , which is an intermediate factor that promotes the production of melanin, by using the compound of the present invention, dendritic cell formation of melanocytes induced by PGE 2 (DC formation). ), which can inhibit melanin delivery to peripheral cells, thereby inhibiting pigmentation.
- the cosmetic composition for skin whitening can inhibit melanin production by preventing the increase of the intermediate factor promoting melanin production, which is the dendritic cell formation of melanocytes caused by the melanogenesis-promoting intermediate factors (
- the intermediate factor promoting melanin production which is the dendritic cell formation of melanocytes caused by the melanogenesis-promoting intermediate factors
- the compound may be treated in a co-culture system of keratinocytes and melanocyte-forming cells to perform skin whitening effect experiments. That is, the skin whitening effect can be confirmed by confirming that the cells are treated with the compound to inhibit the production of PGE 2 , an intermediate factor that promotes the production of melanin.
- the concentration of the compound melanin As an example of the present invention, after activating the protease activating receptor (PAR-2) in the cell to induce the production of the inflammatory substance PGE 2 , when the compound is treated in the cell, the concentration of the compound melanin Through experiments to determine whether production of PGE 2 , which is an intermediate for promoting production, is inhibited, it can be confirmed that the compound has a skin whitening effect by inhibiting melanin production induced by PGE 2 .
- PAR-2 protease activating receptor
- the compound may be treated in the co-culture system of keratinocytes and melanogenesis cells to evaluate the inhibitory effect of melanocyte dendrite cell formation of melanocytes.
- pigmentation is the increase in the dendrite length of the peripheral melanocytes (melanocyte) when the inflammatory agent PGE 2 is increased by PAR-2 activation to facilitate the transfer of melanin to the surrounding cells, the pigmentation Triggered. Accordingly, when the compound represented by Formula 1 of the present invention is treated with melanocytes, skin whitening through melanin production is inhibited through experiments to determine whether dendritic cell formation (DC formation) of melanocytes is inhibited by the compound. Proved effective.
- the cosmetic composition for skin whitening of the present invention may further include phytoestrogens as necessary, but is not limited thereto.
- the phytoestrogens are called phytoestrogens, which are plant-derived natural estrogens, and have functions and structures similar to those of estrogens.
- Larrea Cunefolia which is significant for estrogen activity, such as the compounds of the present invention cuneifolia Cav .
- Extracts The extract of the plant as a zygophyllaceae evergreen shrub, known to be used in folk medicine to treat indigestion in Latin America, but its efficacy is not yet the bar turns to the scientific, La Patria (Larre a) in plants L. Tree Pharmacological actions such as anti-inflammatory, anti-bacterial and anti-viral effects of L. tridentata or L. divaricata shrub have been reported.
- This extract is a phytoestrogens component that can replace the function of estrogen that decreases with age, affects melanocyte formation and inhibition of tyrosinase activity, and inhibits the production of keratinocytes that produce melanocytes. It is thought to help skin whitening by suppressing it.
- the present invention contains a steroid analogue Steroidic Saponoside (Steroidic Saponoside), and further comprises an anti-inflammatory effect of Kigelia Africana extract to give the effect of maintaining the elasticity of the skin tissue of, above all the phytoestrogens la Ria kyune polyamic (Larrea cuneifolia Cav . )
- Steproidic Saponoside Steroid analogue Steroidic Saponoside
- Kigelia Africana extract to give the effect of maintaining the elasticity of the skin tissue of, above all the phytoestrogens la Ria kyune polyamic (Larrea cuneifolia Cav . )
- phytoestrogen phytoestrogen
- the compound represented by the following formula (1) may provide a cosmetic composition for improving skin whitening, characterized in that it contains 0.001 to 10% by weight based on the total weight of the composition It is not. More specifically, containing 0.1 to 10% by weight may have the most excellent efficacy in the whitening effect.
- the raw material efficiency is the highest, the skin whitening effect without the skin irritation is not limited to the range that can be the best.
- the formulation of the cosmetic composition for skin whitening enhancement is not particularly limited and may be appropriately selected as desired.
- toner lotion, lotion, massage cream, nourishing cream, moisturizing cream, hand cream, foundation, essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion or body cleanser But it is not limited thereto.
- the carrier component may be further included according to the formulation, and may be appropriately added according to the formulation.
- solvents, solvating or emulsifying agents can be used, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, glycerol aliphatic esters, polyethylene glycols, Fatty acid esters of sorbitan, aliphatic alcohol sulfates, aliphatic alcohol ether sulfates, sulfosuccinic acid monoesters, isethionates, imidazolinium derivatives, methyltaurate, sarcosinates, fatty acid amide ether sulfates, alkylamidobetaines, aliphatic Alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glyce
- a component included in a general cosmetic composition may be blended as necessary.
- oils and fats, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, flavorings, blood circulation Accelerators, cooling agents, limiting agents, purified water, and the like are not limited thereto.
- a health functional food for improving skin whitening containing the compound represented by the following formula (1) as an active ingredient.
- the functional food for improving skin whitening may provide various types of food additives or functional foods.
- a functional food for improving skin whitening for example, it may be processed into leaching tea, liquid tea, beverage, fermented milk, cheese, yogurt, juice, probiotic and health supplement food, etc. It can be used in the form.
- the formulation of the functional food may be in various forms such as solutions, emulsions, viscous mixtures, tablets, powders, pills, etc., which may be administered by a variety of methods, such as simple drinking, injection, spray or squeeze method. .
- the health functional food for improving skin whitening has an advantage of having an effect of further improving skin whitening by ingesting it in the form of inner beauty food.
- the inner beauty is an inner beauty food called 'eating cosmetics or beauty food', and refers to a food that changes the physical constitution of the skin by absorbing various ingredients that are good for the skin. In consideration of skin condition and lifestyle, you can choose the inner beauty food that suits you. More preferably, when the cosmetic composition containing the cosmetic composition and the inner beauty food containing the compound are mixed, the skin whitening improvement effect is significantly higher than that of using only the cosmetics, so that the effect of improving the skin whitening effect can be seen. Have
- Human-derived keratinocytes Human immortal Keratinocyte
- melanocytes were cultured using a coculture system, and then activated by proteinase-activated receptor-2 (PAR-2).
- PAR-2 proteinase-activated receptor-2
- Cells were treated with 10 ⁇ M of SLIGLV (Ser-Leu-Ile-Gly-Lys-Val-amide) as an inducer for generating PGE 2 .
- SLIGLV Ser-Leu-Ile-Gly-Lys-Val-amide
- the compound of Formula 1 was treated with the cells at concentrations of 0 uM, 25 uM and 50 uM, respectively.
- the melanocytes was immunostained with tyrosinase antibody to observe the dendrite cells (DC) length of the melanocytes.
- the results are shown in Figure 2, it was confirmed that the formation of melanocytes dendritic cells (dendrite cell, DC) in the group treated with the compound of formula 1, compared to the group treated only SLIGLV as a positive control group.
- the compounds and L. kyune polyamic Larrea cuneifolia Cav .
- the formation of melanocyte-dendritic cells was significantly inhibited.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
La présente invention concerne une composition cosmétique permettant de parfaire l'éclaircissement de la peau. Plus précisément, la présente invention concerne : une composition cosmétique permettant de parfaire l'éclaircissement de la peau par l'inhibition d'un facteur intermédiaire favorisant la mélanogenèse ; et un aliment diététique permettant de parfaire l'éclaircissement de la peau, offrant un effet permettant par son administration de parfaire l'éclaircissement de la peau.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG11201707758PA SG11201707758PA (en) | 2015-03-20 | 2016-03-14 | Cosmetic composition for improving skin whitening |
| CN201680029125.4A CN107624065A (zh) | 2015-03-20 | 2016-03-14 | 用于改善皮肤美白的化妆品组合物 |
| MYPI2017703500A MY192729A (en) | 2015-03-20 | 2016-03-14 | Cosmetic composition for improving skin whitening |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150038769A KR102323455B1 (ko) | 2015-03-20 | 2015-03-20 | 피부미백 증진용 화장료 조성물 |
| KR10-2015-0038769 | 2015-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2016153203A1 true WO2016153203A1 (fr) | 2016-09-29 |
Family
ID=56977515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2016/002499 WO2016153203A1 (fr) | 2015-03-20 | 2016-03-14 | Composition cosmétique pour parfaire l'éclaircissement de la peau |
Country Status (5)
| Country | Link |
|---|---|
| KR (1) | KR102323455B1 (fr) |
| CN (1) | CN107624065A (fr) |
| MY (1) | MY192729A (fr) |
| SG (1) | SG11201707758PA (fr) |
| WO (1) | WO2016153203A1 (fr) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020076775A (ko) * | 2001-03-30 | 2002-10-11 | 주식회사 태평양 | 자외선에 의해 증가하는 프로스타글란딘을 억제하는성분과 멜라닌 합성을 억제하는 성분을 동시에 함유하는미백 화장료 조성물 |
| JP2004284990A (ja) * | 2003-03-24 | 2004-10-14 | Kanebo Ltd | 皮膚化粧料及び経口美白剤 |
| JP2011102272A (ja) * | 2009-11-11 | 2011-05-26 | Shiseido Co Ltd | Ｔｉｅ２活性化剤、血管の成熟化、正常化又は安定化剤、リンパ管安定化剤並びにしわ防止・改善剤及びむくみ改善・予防剤 |
| WO2012011908A1 (fr) * | 2010-07-22 | 2012-01-26 | The Procter & Gamble Company | Compositions et procédés permettant d'inhiber l'activation de par2 dans les kératinocytes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09255551A (ja) * | 1996-03-28 | 1997-09-30 | Shiseido Co Ltd | 皮膚外用剤 |
| FR2785804B1 (fr) * | 1998-11-17 | 2002-10-18 | Sederma Sa | Compositions a usage cosmetique ou dermopharmaceutique contenant un extrait de larrea divaricata ou de larrea tridentata pour ralentir le vieillissement cutane |
| CN101085129B (zh) * | 2007-07-11 | 2010-11-10 | 石任兵 | 石菖蒲总酚提取物制备方法 |
| KR101079980B1 (ko) * | 2009-02-12 | 2011-11-04 | 숙명여자대학교산학협력단 | 신이로부터 분리된 리그난 성분과 그 용도 |
| CN104274831A (zh) * | 2013-07-10 | 2015-01-14 | 苏德培 | 一种基于天然衍生肽和炎症抑制剂和/或抗氧化化合物的组合物 |
-
2015
- 2015-03-20 KR KR1020150038769A patent/KR102323455B1/ko active IP Right Grant
-
2016
- 2016-03-14 CN CN201680029125.4A patent/CN107624065A/zh active Pending
- 2016-03-14 SG SG11201707758PA patent/SG11201707758PA/en unknown
- 2016-03-14 WO PCT/KR2016/002499 patent/WO2016153203A1/fr active Application Filing
- 2016-03-14 MY MYPI2017703500A patent/MY192729A/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020076775A (ko) * | 2001-03-30 | 2002-10-11 | 주식회사 태평양 | 자외선에 의해 증가하는 프로스타글란딘을 억제하는성분과 멜라닌 합성을 억제하는 성분을 동시에 함유하는미백 화장료 조성물 |
| JP2004284990A (ja) * | 2003-03-24 | 2004-10-14 | Kanebo Ltd | 皮膚化粧料及び経口美白剤 |
| JP2011102272A (ja) * | 2009-11-11 | 2011-05-26 | Shiseido Co Ltd | Ｔｉｅ２活性化剤、血管の成熟化、正常化又は安定化剤、リンパ管安定化剤並びにしわ防止・改善剤及びむくみ改善・予防剤 |
| WO2012011908A1 (fr) * | 2010-07-22 | 2012-01-26 | The Procter & Gamble Company | Compositions et procédés permettant d'inhiber l'activation de par2 dans les kératinocytes |
Non-Patent Citations (1)
| Title |
|---|
| LI, WEI - JEN ET AL.: "Biofunctional Constituents from Lirioderidron Tulipifera with Antioxidants and Anti-Melanogenic Properties", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 14, no. 1, 2013, pages 1698 - 1712, XP055315119 * |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201707758PA (en) | 2017-10-30 |
| KR102323455B1 (ko) | 2021-11-09 |
| CN107624065A (zh) | 2018-01-23 |
| MY192729A (en) | 2022-09-05 |
| KR20160112655A (ko) | 2016-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106580797A (zh) | 一种美白祛斑霜及其制备方法 | |
| KR102033089B1 (ko) | 항균, 항염증, 피지감소, 각질박리 및 피부진정용 조성물 | |
| JP4233734B2 (ja) | 美白用皮膚外用剤 | |
| EP3643295A1 (fr) | Composition contenant un extrait de cirsium japonicum en tant que principe actif pour stimuler la mélanogenèse | |
| KR101382112B1 (ko) | 편백다당체를 함유하는 피부 외용제 조성물 | |
| CA2819796A1 (fr) | Extrait de parties aeriennes de gynandropsis gynandra ou cleome gynandra et compositions cosmetiques, dermatologiques ou pharmaceutiques le comprenant | |
| KR20200063855A (ko) | 밀크씨슬 꽃 추출물을 유효성분으로 포함하는 멜라닌 생성 촉진용 조성물 | |
| WO2020218888A1 (fr) | Composition cosmétique pour le blanchiment de la peau contenant de nouvelles lactobacillus rhamnosus lm1011 en tant que principe actif | |
| KR20140126892A (ko) | 진세노사이드 Rg3를 함유하는 피부 외용제 조성물 | |
| WO2016110276A1 (fr) | Composition topique renfermant de l'obacunone et procédé pour le blanchiment de la peau | |
| WO2017217695A1 (fr) | Composition comprenant l'alpha-garcinia mangostana, le bêta-garcinia mangostana, le gamma-garcinia mangostana, ou le composé gartanin utilisé comme ingrédient efficace pour atténuer les rides de la peau ou pour hydrater la peau | |
| KR20080049332A (ko) | 미백용 합마유 추출물 | |
| JP2011178770A (ja) | 皮膚の色素沈着を抑制する組成物およびその利用 | |
| KR102286679B1 (ko) | 효소 처리된 차나무 뿌리 유래 사포닌 분획물을 함유하는 피부 외용제 조성물 | |
| KR102154927B1 (ko) | 클로로겐산, 페룰산, 레스베라트롤 및 스트렙토코쿠스 테르모필루스 발효물을 유효성분으로 함유하는 피부 개선용 기능성 화장료 조성물 | |
| KR20100134323A (ko) | 피지 억제 및 여드름 개선용 화장료 조성물 | |
| WO2020091295A1 (fr) | Composition comprenant un extrait d'écorce d'ailanthus altissima en tant que principe actif pour le soin de la peau acnéique ou l'inhibition de la sécrétion de sébum | |
| KR20110067994A (ko) | 송라추출물을 함유하는 피부외용제 조성물 | |
| WO2016153203A1 (fr) | Composition cosmétique pour parfaire l'éclaircissement de la peau | |
| JP2006316020A (ja) | レプチン産生抑制剤 | |
| KR101894747B1 (ko) | 공진단 성분 추출물과 연꽃 추출물을 포함하는 화장료 조성물 | |
| KR20140126891A (ko) | 진세노사이드 Rf를 함유하는 피부 외용제 조성물 | |
| KR20220153866A (ko) | 장미 유래 세포외소포체를 유효성분으로 포함하는 피부 개선용 외용제 조성물 | |
| KR101317433B1 (ko) | 지구자, 길경, 밀싹 및 세이지 추출물을 함유하는 미백 화장용 조성물 | |
| CN101854909B (zh) | 含有桔梗皂苷-d的皮肤美白剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 16769021 Country of ref document: EP Kind code of ref document: A1 |
|
| WWE | Wipo information: entry into national phase |
Ref document number: 11201707758P Country of ref document: SG |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 16769021 Country of ref document: EP Kind code of ref document: A1 |