WO2016141775A1 - 吉林人参低聚肽在制备抗疲劳的食品或保健食品中的用途 - Google Patents

吉林人参低聚肽在制备抗疲劳的食品或保健食品中的用途 Download PDF

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WO2016141775A1
WO2016141775A1 PCT/CN2016/070591 CN2016070591W WO2016141775A1 WO 2016141775 A1 WO2016141775 A1 WO 2016141775A1 CN 2016070591 W CN2016070591 W CN 2016070591W WO 2016141775 A1 WO2016141775 A1 WO 2016141775A1
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fatigue
jilin
food product
ginseng
oligopeptide
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李勇
鲍雷
王军波
石丰
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吉林肽谷生物工程有限责任公司
李勇
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)

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  • the invention relates to a new use of Jilin ginseng oligopeptide, in particular to the use of Jilin ginseng oligopeptide in preparing anti-fatigue food or health food.
  • Fatigue is a normal and important reaction to excessive physical exertion, long-term emotional stress, and lack of sleep, but it is also a non-specific manifestation of psychological or physiological disorders.
  • the pace of life is getting faster, the work intensity is high, eating habits are poor, lack of exercise and other reasons cause people's body resistance to decline, it is easy to produce fatigue.
  • Some anti-fatigue health care products under the prior art have certain curative effects, but the utilization rate is low, and more chemical agents are added, and long-term use may have a negative effect on the human body, so a special product containing safe and effective natural substances is prepared. It is especially urgent to take a meal to prevent and relieve fatigue.
  • a bioactive peptide refers to a peptide compound that is beneficial or physiologically active to the living activities of a living organism.
  • Peptides are intermediate in amino acid and protein in molecular structure, but they have functions that cannot be replaced by amino acids and proteins.
  • Oligopeptides also known as active small molecule peptides, generally consist of 10 or fewer amino acids. Studies have found that oligopeptides are more effective than single amino acid absorption and can directly participate in protein synthesis, thus improving the body's protein utilization. In the case of obstacles in the amino acid transport system, the ingestion of oligopeptides can achieve good absorption.
  • bioactive peptides have a wide range of biological activities, such as immune regulation, cholesterol lowering, blood pressure lowering, antithrombotic, anti-cancer, anti-viral, anti-oxidation and scavenging free radicals, and promote growth.
  • bioactive peptides have emerged with their high efficiency and safety, and gradually show their important role in clinical nutrition and broad application prospects.
  • Ginseng is a valuable Chinese herbal medicine.
  • the medicinal use of ginseng has been more than 4,000 years old.
  • the ginseng of our country is the dry root and rhizome of the ginseng of the Araliaceae plant, which is mainly produced in Jilin province. On September 4, 2012, the Ministry of Health of China approved ginseng as a new resource food.
  • Ginseng has the effects of replenishing vitality, quenching thirst, and calming the nerves.
  • a large number of pharmacological studies, clinical observations and epidemiological investigations have confirmed that ginseng has many biological activities such as improving microcirculation, improving tissue anti-hypoxia ability, inhibiting platelet aggregation, anti-tumor, anti-aging, anti-radiation and anti-fatigue. .
  • the chemical composition of ginseng is extremely complicated.
  • Ginseng oligopeptide can be directly absorbed in the human body without digestion, thus avoiding waste of active substances and greatly improving its medicine. It can be used as a new formula for foods or health products with anti-fatigue effects.
  • the object of the present invention is to provide a low-viscosity, easily absorbed and fast-absorbing Jilin ginseng oligopeptide in the preparation of anti-fatigue food or health food, and provides a new way for relieving fatigue through diet.
  • the food described therein is a powder, a liquid beverage, a milk powder, and a dairy or bakery product.
  • the health food described therein is a powder, a tablet, a soft/hard capsule or an oral solution.
  • Jilin Ginseng Oligopeptide has anti-fatigue function, and its use in preparing anti-fatigue food or health food has been found.
  • Animal experiments have found that supplementation of Jilin ginseng oligopeptides can delay the production of fatigue in experimental mice and accelerate the elimination of fatigue, with significant anti-fatigue effects.
  • Sample Jilin ginseng oligopeptide, produced by Jilin Peptide Bioengineering Co., Ltd., light yellow solid powder, the main component is a small molecule oligopeptide with molecular weight less than 1000, the content is 93.45%, and the free amino acid accounts for 3.94%.
  • mice 336 healthy and clean ICR male mice, 6-8 weeks old, weighing 18-22 g, were provided by the Experimental Animal Center of Peking University Medical School. The experimental animals were kept in cages, 6 per cage, free to eat and drink. The animal feeding laboratory meets the national standard clean level, the temperature range is 25 °C ⁇ 1 °C, the relative humidity is 50% ⁇ 60%, and the indoor lighting is controlled at 12h/12h light and dark cycle rhythm.
  • Dosage and grouping 336 male ICR mice were weighed before the experiment, and were randomly divided into 7 groups according to body weight, 48 in each group.
  • each group of animals were subdivided into 4 subgroups, 12 in each group.
  • mice were given distilled water, and the other groups were given the corresponding concentrations of whey protein and aqueous solution of Jilin ginseng oligopeptide. Each group of mice was given normal feed, free to eat and drink. The rats were intragastrically administered once a day, and each experiment was carried out after 30 days of continuous gavage.
  • mice in the first subgroup of each group were taken, and after 30 min of the last test sample, the lead was loaded with 5% body weight at the root of the rat tail.
  • the skin was then placed in a swimming pool (water depth ⁇ 30 cm, water temperature 25 ° C ⁇ 1.0 ° C), and the time from the start of swimming to exhaustion of the mice was recorded as the weight-bearing swimming time of the mice.
  • mice in the second subgroup of each group were given 30 min after the last test, and the test sample was given for 30 min at the last time. After swimming for 30 min in water at a temperature of 30 ° C, the eyeball was taken for 60 min.
  • the serum was placed in a refrigerator at 4 °C for about 3 hours, centrifuged at 2000 r/min for 15 minutes, and the serum urea nitrogen content and lactate dehydrogenase activity were measured by the Olympus Co., Ltd. automatic biochemical analyzer AU400.
  • the reagents were all made by Yingke Xinchuang (Xiamen). Technology Co., Ltd. reagent.
  • mice Effect of Jilin ginseng oligopeptide on serum urea nitrogen and lactate dehydrogenase activity in mice
  • liver glycogen level of Jilin ginseng oligopeptide 2 and 3 groups was significantly higher than that of whey protein group (p>0.05). ⁇ 0.01 and p ⁇ 0.05), see Table 3.
  • Jilin ginseng oligopeptide can delay the production of fatigue and accelerate the elimination of fatigue, thus playing a role in anti-fatigue. It has the potential as a new anti-fatigue agent, and its suitable concentration range is 0.125 ⁇ 1g/kg per day.

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Abstract

吉林人参低聚肽在制备抗疲劳的食品或保健食品中的用途。

Description

吉林人参低聚肽在制备抗疲劳的食品或保健食品中的用途 技术领域
本发明涉及吉林人参低聚肽的一种新用途，具体来说是吉林人参低聚肽在制备抗疲劳的食品或保健食品中的用途。
背景技术
疲劳是身体过度劳累、长期情绪紧张、缺乏睡眠时正常的和重要的反应，但也是一种心理或生理障碍的非特异性表现。随着经济的飞速发展，生活节奏变快，工作强度大、饮食习惯不良、缺乏运动锻炼等多种原因造成人们身体抵抗力下降，很容易产生疲劳。现有技术下的一些抗疲劳的保健品虽有一定疗效，但利用率低，且多添加化学制剂，长期服用可能会对人体产生负作用，因此制备一种含有安全而有效的天然物质的特殊膳食来预防和缓解疲劳显得尤为迫切。
生物活性肽是指对生物机体的生命活动有益或具有生理作用的肽类化合物。肽在分子结构上处于氨基酸和蛋白质的中间位置，但它具有氨基酸和蛋白质所不能替代的功能。低聚肽，又称为活性小分子肽，一般由10个或10个以下氨基酸组成。研究发现低聚肽比单个氨基酸的吸收更有效，且能直接参与蛋白质的合成，因此提高了机体对蛋白质的利用率。在氨基酸运输系统出现障碍的情况下，摄入低聚肽却能获得良好的吸收效果。另外，生物活性肽类具有广泛的生物活性，如免疫调节、降胆固醇、降血压、抗血栓、抗癌、抗病毒、抗氧化和清除自由基作用、促进生长等。目前生物活性肽以其高效、安全的特点异军突起，逐渐显示出其在临床营养中的重要作用和广泛的应用前景。
人参为名贵中药材，有关人参的药用已经有四千多年的历史。目前世界上的人参主要有四种：即我国的“吉林人参”、朝鲜的“高丽参”、日本的“东洋参”和加拿大、美国的“西洋参”。我国的人参为五加科植物人参的干燥根及根茎，主要产于吉林省。2012年9月4日，中国卫生部批准人参成为新资源食品，人参的应用将由单一的中药材及保健产品拓展到食品、饮料等领域，范围大幅扩大，这为我国的人参产业发展提供了新的契机。人参具有大补元气、生津止渴、安神等功效。近年来，大量药理研究、临床观察和流行病学调查研究均证实人参具有改善微循环、提高组织抗缺氧能力、抑制血小板聚集、抗肿瘤、抗衰老、抗辐射、抗疲劳等多种生物活性。人参的化学成分极为复杂，目前对人参皂甙的研究比较多，而其中的低聚肽类作为人参中重要的成分相对研究较少，关于其在抗疲劳食品或保健食品中的应用未见报道。人参低聚肽在人体不需消化可直接吸收，因而可避免活性物质的浪费，大大提高其药 效，可作为一种新型的具有抗疲劳作用的食品或保健品的配方。
发明内容
本发明的目的在于提供一种低粘度、易吸收且吸收快的吉林人参低聚肽在制备抗疲劳食品或保健食品中的用途，为通过饮食来缓解疲劳提供一种新途径。
其中所述的食品为粉剂、液体饮料、奶粉及奶制品或烘焙制品。
其中所述的保健食品为粉剂、片剂、软/硬胶囊或口服液。
本发明发现了现有物质—吉林人参低聚肽具有抗疲劳的功能，发现了其在制备抗疲劳的食品或保健食品中的用途。动物实验发现补充吉林人参低聚肽能够延缓实验小鼠疲劳的产生和加速疲劳的消除，具有显著的抗疲劳功效。
具体实施方式
下面结合具体实施例对本发明做进一步说明，这些实例应被理解为仅是举例说明，而非以任何方式限制本发明的范围。
实施例1、对实验小鼠抗疲劳作用的研究
一、材料和方法
样品：吉林人参低聚肽，由吉林肽谷生物工程有限责任公司生产，淡黄色固体粉末，主要成分为分子量小于1000的小分子寡肽，含量为93.45％，游离氨基酸占3.94％。
实验动物：健康清洁级ICR雄性小鼠336只，6～8周龄，体重18～22g，由北京大学医学部实验动物中心提供。实验动物分笼饲养，每笼6只，自由饮食、饮水。动物饲养实验室符合国标清洁级，温度范围25℃±1℃，相对湿度50％～60％，室内照明控制在12h/12h光暗周期节律。
二、实验方法
剂量及分组：雄性ICR小鼠336只，实验前称小鼠体重，按体重随机分为7组，每组48只。设立空白对照组、乳清蛋白组(0.50g/kg·bw)及5个吉林人参低聚肽剂量组(0.125g/kg·bw0.25g/kg·bw、0.50g/kg·bw、1.00g/kg·bw、2.00g/kg·bw，分别用吉林人参低聚肽一、二、三、四、五组来表示)，各组动物再分为4个亚组，每组12只。空白对照组小鼠灌胃蒸馏水，其余各组灌胃相应浓度的乳清蛋白及吉林人参低聚肽的水溶液。各组小鼠均给以普通饲料，自由进食和饮水。每天灌胃1次，连续灌胃30d后进行各项实验。
1)负重游泳实验
取各组第1亚组12只小鼠，末次给予受试样品30min后，在鼠尾根部负荷5％体重的铅 皮，然后将小鼠置于游泳箱中游泳(水深≥30cm，水温25℃±1.0℃)，记录小鼠自游泳开始至力竭死亡的时间，作为小鼠负重游泳时间。
2)血清尿素氮和乳酸脱氢酶活力的测定
取各组第2亚组12只小鼠，末次给予受试物30min后，末次给受试样品30min后，在温度为30℃的水中不负重游泳90min，休息60min后拔眼球采血。置4℃冰箱约3h，2000r/min离心15min分离血清，用日本奥林巴斯株式会社全自动生化仪AU400测定血清尿素氮含量和乳酸脱氢酶活力，试剂均采用英科新创(厦门)科技有限公司试剂。
3)肝糖原测定
取各组第3亚组12只小鼠，末次给予受试物30min后处死动物，取新鲜肝脏样本用生理盐水漂洗后，滤纸吸干，精确称取肝脏，按标本重量(mg)：碱液体积(μg)＝1：3，一起加入试管中，沸水浴20min，流水冷却后按肝糖原测定试剂盒说明书进行，试剂盒购自南京建成生物工程研究所。
4)血乳酸测定
取各组第4亚组12只小鼠，末次给予受试物30min后采尾血20μl，然后小鼠不负重在温度为30℃的水中游泳10min，再于游泳后0min和20min各分别采血20μl，将3次采得的血样分别加入0.48ml 1％NaF溶液中充分混匀至透明，然后加入1.5ml蛋白沉淀剂，振荡混匀，3000r/min离心10min，取上清液测定乳酸含量。血乳酸曲线下面积＝1/2×(游泳前血乳酸值+游泳后0min的血乳酸值)×10+1/2×(游泳后0min的血乳酸值+游泳后休息20min的血乳酸值)×20
统计方法：所有实验数据均以
Figure PCTCN2016070591-appb-000001
表示。采用SPSS13.0软件进行单因素方差分析，p<0.05有统计学意义。
三、实验结果
1)吉林人参低聚肽对小鼠负重游泳时间的影响
如表1所示，空白对照组与乳清蛋白组小鼠负重游泳时间无显著性差异(p﹥0.05)；与乳清蛋白组相比，吉林人参低聚肽各剂量组小鼠负重游泳时间均有一定程度的延长，其中吉林人参低聚肽二组最为显著(p﹤0.01)。
2)吉林人参低聚肽对小鼠血清尿素氮和乳酸脱氢酶活性的影响
如表2所示，空白对照组与乳清蛋白组小鼠血清尿素氮和乳酸脱氢酶活性均无显著性差异(p﹥0.05)；而与乳清蛋白组相比，吉林人参低聚肽各剂量组血清尿素氮含量均有所降低，乳酸脱氢酶活性有所增强，其中吉林人参低聚肽一组和吉林人参低聚肽二组的差异具有统计学意义(p﹤0.05或p﹤0.01)。
表1 吉林人参低聚肽对小鼠游泳时间的影响(
Figure PCTCN2016070591-appb-000002
n＝12)
Figure PCTCN2016070591-appb-000003
注：*表示与乳清蛋白组相比p﹤0.05。
表2 吉林人参低聚肽对小鼠血清尿素氮和乳酸脱氢酶活性的影响(
Figure PCTCN2016070591-appb-000004
n＝12)
Figure PCTCN2016070591-appb-000005
注：*表示与乳清蛋白组相比p﹤0.05；**表示与乳清蛋白组相比p﹤0.01。
3)吉林人参低聚肽对小鼠肝糖原含量的影响
空白对照组和乳清蛋白组小鼠肝糖原含量差异无统计学意义(p﹥0.05)；吉林人参低聚肽二组和三组小鼠肝糖原水平显著高于乳清蛋白组(p﹤0.01和p﹤0.05)，见表3。
表3 吉林人参低聚肽对小鼠肝糖原含量的影响(
Figure PCTCN2016070591-appb-000006
n＝12)
Figure PCTCN2016070591-appb-000007
注：*表示与乳清蛋白组相比p﹤0.05；**表示与乳清蛋白组相比p﹤0.01。
4)吉林人参低聚肽对小鼠血乳酸含量的影响
空白对照组和乳清蛋白组小鼠各时间段的血乳酸含量均无统计学差异(p﹥0.05)；吉林人参低聚肽二组和三组小鼠游泳后0min以及吉林人参低聚肽一、二、三组小鼠游泳后20min血乳酸水平显著低于乳清蛋白组(p﹤0.05或p﹤0.01)；吉林人参低聚肽除第五组小鼠外其余四组小鼠3个时间点血乳酸曲线下面积均小于乳清蛋白组，且差异有统计学意义(p﹤0.05或p﹤0.01)，见表4。
表4 吉林人参低聚肽对小鼠血乳酸的影响(
Figure PCTCN2016070591-appb-000008
n＝12)
Figure PCTCN2016070591-appb-000009
注：*表示与乳清蛋白组相比p﹤0.05；**表示与乳清蛋白组相比p﹤0.01。
四、实验结论
本研究通过设立空白对照组和乳清蛋白组作为对照组，探讨吉林人参低聚肽的抗疲劳作用。结果表明，吉林人参低聚肽可以延缓疲劳的产生和加速疲劳的消除，从而起到抗疲劳的作用，具备作为一种新型抗疲劳制剂的潜力，其适宜浓度范围为每天0.125～1g/kg·bw。

Claims (3)

  1. 吉林人参低聚肽在制备抗疲劳的食品或保健食品中的用途。
  2. 根据权利要求1所述的吉林人参低聚肽在制备抗疲劳的食品或保健食品中的用途，其特征在于：所述抗疲劳的食品为粉剂、液体饮料、奶粉及奶制品和烘焙制品。
  3. 根据权利要求1所述的吉林人参低聚肽在制备抗疲劳的食品或保健食品中的用途，其特征在于：所述改善和增强性功能的保健食品为粉剂、片剂、软/硬胶囊和口服液。
PCT/CN2016/070591 2015-03-11 2016-01-11 吉林人参低聚肽在制备抗疲劳的食品或保健食品中的用途 WO2016141775A1 (zh)

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