WO2016129100A1 - Agent permettant d'augmenter le nombre de bactéries utiles dans les intestins d'animaux, et méthode permettant d'améliorer l'environnement intestinal du bétail dans lequel est utilisé ledit agent - Google Patents

Agent permettant d'augmenter le nombre de bactéries utiles dans les intestins d'animaux, et méthode permettant d'améliorer l'environnement intestinal du bétail dans lequel est utilisé ledit agent Download PDF

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Publication number
WO2016129100A1
WO2016129100A1 PCT/JP2015/053961 JP2015053961W WO2016129100A1 WO 2016129100 A1 WO2016129100 A1 WO 2016129100A1 JP 2015053961 W JP2015053961 W JP 2015053961W WO 2016129100 A1 WO2016129100 A1 WO 2016129100A1
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WO
WIPO (PCT)
Prior art keywords
livestock
bacteria
useful bacteria
agent
feed
Prior art date
Application number
PCT/JP2015/053961
Other languages
English (en)
Japanese (ja)
Inventor
山田　豊
松井　宏樹
Original Assignee
油化産業株式会社
国立大学法人三重大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 油化産業株式会社, 国立大学法人三重大学 filed Critical 油化産業株式会社
Priority to KR1020177018724A priority Critical patent/KR102376381B1/ko
Priority to PCT/JP2015/053961 priority patent/WO2016129100A1/fr
Priority to JP2016574594A priority patent/JP6557686B2/ja
Publication of WO2016129100A1 publication Critical patent/WO2016129100A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry

Definitions

  • the present invention relates to an agent for increasing useful intestinal bacteria that increases useful bacteria present in the intestines of animals.
  • the present invention improves the intestinal environment of livestock by increasing useful bacteria in the intestinal flora of livestock and decreasing harmful bacteria using the animal intestinal useful bacteria increasing agent of the present invention. Therefore, the present invention also relates to a method for improving the intestinal environment of livestock, which improves and maintains digestive physiological functions and immune functions, prevents the occurrence of diseases, and improves the efficient productivity of livestock.
  • the “animal” in the present invention is a vertebrate such as mammals, birds, reptiles, amphibians, fish, and the like, for example, humans, domestic animals, primates (monkeys, chimpanzees, etc.), laboratory animals (mouse, rats, etc.), etc. is there.
  • the term “livestock” in the present invention refers to industrial animals, pets, pets for viewing, and sporting animals that are accustomed or raised for human use of their products (milk, meat, eggs, etc.). There are, for example, cows, pigs, sheep, goats, horses, poultry, dogs, cats, small birds, fish farms and the like.
  • the intestinal flora includes useful and harmful bacteria.
  • useful bacteria include bacteria belonging to the genus Lactobacillus ⁇ and Bifidobacterium ⁇ . And the like. The balance of competitive growth between these useful bacteria and harmful bacteria is disrupted, resulting in an enteric bacterial flora that predominates harmful bacteria, causing a decline in immune function and digestive physiology. It is thought to lead to a decrease in productivity.
  • Patent Document 1 a nutritional supplement for livestock containing higher fatty acid triglycerides and medium chain fatty acid triglycerides
  • Patent Document 2 Dairy substitute milk composition for the purpose of improving soft stool and reducing stress
  • Patent Document 3 A milk replacer composition
  • Patent Document 4 a medium containing a medium chain fatty acid mixture
  • Patent Document 4 a pharmaceutical for inhibiting contamination by E. coli have been reported.
  • JP-A-6-153812 Japanese Patent Laid-Open No. 10-127232 Japanese Patent No. 2723961 Japanese Patent No. 5259905
  • the present invention aims at improving the intestinal environment of animals such as livestock, preventing the occurrence of diseases, and improving the productivity of livestock, paying attention to the above series of matters.
  • the present inventors have increased useful bacteria among intestinal flora of animals such as livestock, and reduced harmful bacteria. As a result, it has been found that the intestinal environment can be improved, and the occurrence of diseases and reduction in productivity can be prevented, and the present invention has been completed.
  • the present invention is an animal intestinal useful bacteria increasing agent containing at least one fatty acid selected from the group consisting of caprylic acid, capric acid and lauric acid or a salt thereof. Further, the present invention is a method for improving the intestinal environment of livestock, characterized in that a feed containing 0.1 to 2% by weight of the animal enteric useful bacteria increasing agent of the present invention is fed to livestock.
  • the animal intestinal useful bacteria increasing agent of the present invention increases the useful bacteria among the intestinal bacterial flora of animals such as livestock, and lowers harmful bacteria to make the animal's intestinal environment a dominant bacterial flora predominantly useful bacteria.
  • caprylic acid, capric acid, and lauric acid which are the main components, are essentially substances that have extremely high absorption rates and metabolic rates, and are also effective in that vitality can be obtained quickly by ingestion.
  • the method for improving the intestinal environment of livestock of the present invention can improve the intestinal environment of livestock, prevent the occurrence of diseases, and improve the productivity.
  • the animal intestinal useful bacteria increasing agent of the present invention is at least one fatty acid selected from the group consisting of caprylic acid, capric acid and lauric acid, or a salt thereof (hereinafter referred to as “the useful bacteria increasing agent”). , Also referred to as “fatty acid etc.”). It is preferable to contain two types of fatty acids or salts selected from the group consisting of caprylic acid, capric acid and lauric acid, and it is particularly preferable to contain these three types of fatty acids or salts.
  • fatty acid salt calcium salts and magnesium salts of the above-mentioned various fatty acids are preferable because they are essential mineral components for livestock, and these may be used singly or in combination of two.
  • These fatty acid metal salts are solid at room temperature, and are easy to handle and mix with feed, and in view of their effects on ruminant rumen, these fatty acid metal salts are included in lipids. Is preferred. In particular, it is more preferable to use solid powder or granular fatty acid calcium or fatty acid magnesium.
  • the useful bacteria increasing agent of the present invention can be applied to livestock such as cattle, pigs, chickens, etc., for example, short-term breeding with high breeding density (head or feather / area), switching to feed with different nutrition and form, heat, Diseases can be prevented by reducing harmful bacteria in the intestines and increasing useful bacteria during periods of various management stresses such as cold, weaning, group movements based on people in the farm, and long-distance transportation of livestock. It is possible to prevent this, maintain feed intake and promote growth, and maintain productivity.
  • Harmful bacteria that can be reduced by feeding livestock feed containing the useful bacteria increasing agent of the present invention include, for example, Escherichia Coli, Salmonella genus, Clostridium perfingers, etc. In particular, it has a strong effect on Escherichia Coli and Clostridium f perfingers.
  • useful bacteria that can be increased by feeding the animal feed of the present invention include bacteria belonging to the genus Lactobacillus genus and Bifidobacterium genus.
  • the useful bacteria increasing agent of the present invention may contain known additives such as carriers and excipients.
  • the content of the fatty acid or the like in the useful bacterium increasing agent of the present invention is preferably 70% by weight or more, particularly preferably 90% by weight or more, and further preferably 95% by weight or more. If the content is less than 70% by weight, it may be insufficient for improving the intestinal flora of animals, and other components such as long chain fatty acids and minerals will be fed, which is inefficient.
  • the useful bacteria increasing agent and livestock feed of the present invention can be used as food additives, pharmaceuticals, and also as livestock feed additives.
  • Livestock feed may contain, for example, corn flour, rice flour, flour such as rice bran, minerals, amino acids, proteins, vitamins, lipids and the like.
  • it may contain ingredients described in the Japan Standard Feed Ingredients Table (2009 edition, edited by the National Agriculture and Food Research Organization).
  • the form of the useful bacteria increasing agent and livestock feed of the present invention may be any form such as liquid, paste, powder, granule, pellet, etc., and can be prepared by a known method according to the desired form. it can.
  • the useful bacterium increasing agent of the present invention is 0.1 to 2% by weight, preferably 0.10 to 1.5% by weight, particularly preferably 0.5 to 1% by weight. It is characterized by feeding the mixed feed to livestock. If the amount of feed for livestock is less than 0.1% by weight in the feed, the effects of the present invention may not be obtained.
  • the feed frequency and the amount of feed containing the useful bacteria increasing agent of the present invention vary depending on the physical properties of the feed, the type of livestock and the body weight (age), etc., and the normal feed frequency and amount of the feed are adopted. can do.
  • caprylic acid Ca As the livestock feed used in the examples, four types of livestock feeds of caprylic acid Ca, capric acid Ca, lauric acid Ca, caprylic acid / capric acid / lauric acid mixed fatty acid Ca were prepared.
  • the fatty acid content of livestock feed is shown in Table 1.
  • Examples 1 to 5, Comparative Examples 1 to 5 The feed for livestock shown in Tables 3 and 4 was fed for 3 weeks using 50 Holstein milking cows fed with water and the basic feed shown in Table 2 for each Example and Comparative Example. Feces were sampled 3 weeks after feeding and stored frozen until analysis. Fecal bacteria counts were investigated for Bifidobacterium, Escherichia coli, Salmonella, Campylobacter jejumi, and Clostridium perfringens by real-time PCR. Specifically, the number of bacteria is determined by the procedure of 1) extracting DNA from the sample, 2) analyzing the DNA using each PCR method, and 3) quantifying the number of bacteria based on the proportional relationship between the gene amount and the number of bacteria. Asked.
  • Examples 6 to 10, Comparative Examples 6 to 10 Using 50 LWD castrated pigs fed with water and the basic feed shown in Table 11 for each of the Examples and Comparative Examples, the livestock feed shown in Tables 12 and 13 was fed for 2 weeks. did. Feces were sampled 2 weeks after feeding and stored frozen until analysis. The number of bacteria in the feces was determined by real-time PCR using the genera Bifidobacterium, Escherichia coli, Salmonella, Campylobacter jejumi., Clostridium perfringens. Was investigated.
  • the number of bacteria is determined by the procedure of 1) extracting DNA from the sample, 2) analyzing the DNA using each PCR method, and 3) quantifying the number of bacteria based on the proportional relationship between the gene amount and the number of bacteria. Asked. Then, it was calculated as a relative value with the number of swine bacteria before feeding as 1.
  • nine kinds of bacteria belonging to the genus Lactobacillus in stool that is, Lactobacillus acidophilus, Lactobacillus casei-group, Lactobacillus delbrueckii, Lactobacillus gasseri, Lactobacillus plantarum, Lactobacillus rhamnosus, and Lactobacillus reuteri were detected by multiplex PCR.
  • the feed efficiency was calculated from the incidence of diarrhea during the feeding period, the feed intake and the body weight for 2 weeks of feeding.
  • the results of each example are shown in Table 14, Table 16, Table 18, and Table 19, and the results of each comparative example are shown in Table 15, Table 17, Table 18, and Table 19, respectively.
  • the fecal Bifidobacterium genus increased 1.16 to 1.35 times, Escherichia coli 0.79 to 0.26 times, and Salmonella genus 0. It decreased from 84 times to 0.21 times, Campylobacter jejumi from 0.88 times to 0.60 times, and Clostridium pefringens from 0.89 times to 0.66 times.
  • the Biffidobacterium genus was not significantly changed from 0.93 to 1.00 times, and Escherichia Coli was from 1.00 times to 1.11 times. Salmonella genus increased 1.05 to 1.16 times, Campylobacter jejumi 1.15 to 1.27 times, and Clostridium perfringens 1.08 to 1.29 times.
  • the ratio (detection rate) of the number of Lactobacillus species in the feces of Examples 6 to 10 was 40% to 60% for L. acidophilus, 20% to 80% for L. delbrueckii, and L. delbrueckii. Gasseri was 60% to 80%, and L. rhamnosus was 40% to 60%.
  • L. acidophilus was 0% to 20%
  • L. delbrueckii was 0% to 20%
  • L. gasseri was 0% to 20%
  • the detection rate was as low as 0% to 20%, and other bacteria were not detected.
  • Example 11 to 15, Comparative Examples 11 to 15 Feeding the livestock feeds shown in Table 21 and Table 22 for 5 weeks using 100 three-week-old broiler chickens fed with water and the basic feed shown in Table 20 for each Example and Comparative Example did. Feces were sampled from 5 birds in each ward 2 weeks after feeding and stored frozen until analysis. Fecal bacteria count was investigated for Bifidobacterium genus, Escherichia coli, Salmonella genus, Campylobacter jejumi., And Clostridium perfringens by real-time PCR.
  • the number of bacteria is determined by the procedure of 1) extracting DNA from the sample, 2) analyzing the DNA using each PCR method, and 3) quantifying the number of bacteria based on the proportional relationship between the gene amount and the number of bacteria. Asked. And it calculated as a relative value by setting the number of broiler bacteria before feeding to 1.
  • nine kinds of bacteria belonging to the genus Lactobacillus in stool that is, Lactobacillus acidophilus, Lactobacillus casei-group, Lactobacillus delbrueckii, Lactobacillus gasseri, Lactobacillus plantarum, Lactobacillus rhamnosus, and Lactobacillus reuteri were detected by multiplex PCR.
  • the growth rate after 5 weeks of salary was investigated.
  • the results of each example are shown in Table 23, Table 25, and Table 27, and the results of each comparative example are shown in Table 24, Table 26, and Table 27, respectively.
  • the ratio (detection rate) of the number of detected genus Lactobacillus in Examples 11 to 15 was 40% to 60% for L. acidophilus, 40% to 60% for L. delbrueckii, and L Gasseri was detected from 40% to 80% and L. rhamnosus was detected from 40% to 80%.
  • L. delbrueckii was 0% to 20%
  • L. gasseri was 0% to 20%
  • the detection rate was low, and other bacteria were detected. There wasn't.
  • the growth rate of Examples 11 to 15 was 99 to 100%. In contrast, in Comparative Examples 11 to 15, the growth rate was 95 to 97%, which was lower than those in Examples 11 to 15.
  • the animal intestinal useful bacteria increasing agent of the present invention can improve the intestinal environment of the animal by increasing useful bacteria existing in the intestine of the animal and reducing harmful bacteria. It can be used as a pharmaceutical or as an additive for livestock feed. In particular, by feeding a livestock feed containing a specific amount of the animal intestinal useful bacteria increasing agent of the present invention, increasing the useful bacteria in the intestinal flora of livestock and reducing harmful bacteria It is possible to improve the intestinal environment of livestock, thereby preventing the occurrence of diseases and improving the productivity of livestock.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Fodder In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'objet de la présente invention est d'améliorer l'environnement intestinal chez des animaux tels que du bétail, et de prévenir ainsi une maladie avant qu'elle ne survienne, et d'améliorer la productivité du bétail. Cet agent permettant d'augmenter le nombre de bactéries utiles dans les intestins d'animaux contient au moins un acide gras choisi dans le groupe constitué par de l'acide caprylique, de l'acide caprique, et de l'acide laurique, ou des sels de ceux-ci.
PCT/JP2015/053961 2015-02-13 2015-02-13 Agent permettant d'augmenter le nombre de bactéries utiles dans les intestins d'animaux, et méthode permettant d'améliorer l'environnement intestinal du bétail dans lequel est utilisé ledit agent WO2016129100A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020177018724A KR102376381B1 (ko) 2015-02-13 2015-02-13 동물장내 유용균 증가제 및 이것을 사용한 가축장내 환경개선방법
PCT/JP2015/053961 WO2016129100A1 (fr) 2015-02-13 2015-02-13 Agent permettant d'augmenter le nombre de bactéries utiles dans les intestins d'animaux, et méthode permettant d'améliorer l'environnement intestinal du bétail dans lequel est utilisé ledit agent
JP2016574594A JP6557686B2 (ja) 2015-02-13 2015-02-13 動物腸内有用菌増加剤及びこれを用いた家畜腸内環境改善方法

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PCT/JP2015/053961 WO2016129100A1 (fr) 2015-02-13 2015-02-13 Agent permettant d'augmenter le nombre de bactéries utiles dans les intestins d'animaux, et méthode permettant d'améliorer l'environnement intestinal du bétail dans lequel est utilisé ledit agent

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Cited By (1)

* Cited by examiner, † Cited by third party
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CN109688832A (zh) * 2016-09-02 2019-04-26 富士胶片株式会社 家畜用饲料或家畜用补充剂、乳杆菌属细菌的生长促进剂以及乳杆菌属细菌的生长促进方法

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JPWO2016129100A1 (ja) 2017-11-24
JP6557686B2 (ja) 2019-08-07
KR20170117382A (ko) 2017-10-23
KR102376381B1 (ko) 2022-03-17

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