WO2016108233A1 - Cosmetic topical skin and hair treatment formulation - Google Patents
Cosmetic topical skin and hair treatment formulation Download PDFInfo
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- WO2016108233A1 WO2016108233A1 PCT/IL2015/051263 IL2015051263W WO2016108233A1 WO 2016108233 A1 WO2016108233 A1 WO 2016108233A1 IL 2015051263 W IL2015051263 W IL 2015051263W WO 2016108233 A1 WO2016108233 A1 WO 2016108233A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
- A61K8/70—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine containing perfluoro groups, e.g. perfluoroethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Definitions
- Patent Application Serial Number 236521 filed August 5, 2005, entitled “Cosmetic Topical Skin and Hair Treatment Formulation.”
- the aforementioned application is hereby incorporated herein by reference.
- the present invention relates to a cosmetic treatment formulation.
- the invention particularly relates to cosmetic treatment including a combination of oils and an oxygen carrier.
- Skin is the soft outer covering of vertebrates. In mammals the skin guards the underlying muscles, bones, ligaments and internal organs. Mammals may have also some hair on their skin.
- the skin is one of the most important organs of the body because it interfaces with the environment and is the first line of defense from external factors. For example, the skin plays a key role in protecting the body against pathogens and excessive water loss. Other functions of the skin include insulation, temperature regulation and sensation.
- the skin has three layers - the epidermis, the dermis and the subcutis (or hypodermis).
- the epidermis forms the surface of the skin. It is made up of several layers of cells called keratinocytes.
- the dermis lies underneath the epidermis and contains skin appendages: hair follicles, sebaceous (oil) glands and sweat glands.
- the subcutis contains fat cells and some sweat glands.
- the protective barrier of the skin is the hydrolipidic film, also known as the skin barrier, which contains aqueous substances and oils produced by the sebaceous glands. The function of the skin barrier is to retain moisture, protect against the entrance of germs and fungi into the skin and protect against UV radiation - a leading cause of premature aging signs. An intact skin barrier maintains the skin's natural suppleness.
- Oxygen is used by skin cells to produce energy to fuel cellular processes such as proliferation and production of extracellular matrix substances both which are essential for maintaining healthy, young looking skin. Oxygen levels in the skin are lower than other parts of the body and are known to decrease further with age.
- Sebum contributes to the skin's slightly acidic natural pH somewhere between 5 and 6.8 on the pH spectrum. This oily substance gives hair moisture and shine as it travels naturally down the hair shaft, and serves as a protective substance preventing the hair from drying out or absorbing excessive amounts of external substances.
- Hair follicles are the mammalian skin organ that produces hair.
- the hair follicle includes papilla which is a large structure at the base of the hair follicle made up mainly of connective tissue and a capillary loop.
- papilla Around the papilla is the hair matrix, a collection of epithelial cells often interspersed with pigment-producing cells. Cell division in the hair matrix produces the cells that form the major structures of the hair fiber and the inner root sheath.
- the hair matrix epithelium is one of the fastest growing cell populations in the human body.
- the root sheath is composed of an external and internal root sheath.
- the internal root sheath is composed of three layers where the internal cuticle layer is continuous with the outermost layer of the hair fiber.
- the bulge is located in the outer root sheath and houses several types of stem cells that are supplied to the hair follicle.
- the hair follicle stem cells are responsible for hair production as well as regeneration of the epidermis and sebaceous glands.
- Other structures associated with the hair follicle include the cup in which the follicle grows known as the infundibulum, the arrector pili muscles, the sebaceous glands, and the apocrine sweat glands. Hair follicle receptors sense the position of the hair.
- Each arrector pili is composed of bundle of smooth muscle fibers which are attached to several follicles (a follicular unit) and are innervated by the sympathetic branch of the autonomic nervous system.
- the contraction of the muscle is therefore involuntary. Stresses such as cold, fear etc. may stimulate the sympathetic nervous system and thus cause temporarily contraction.
- the sebaceous glands are microscopic exocrine glands in the skin that secrete an oily or waxy matter, called sebum that lubricates and waterproof the skin and hair.
- Essential oils are extracts of plants that have been screened for their potential uses as being source of biologically active compounds.
- the greatest obstacle for trans-dermal delivery is the barrier property of the stratum corneum.
- Many approaches have been employed to breach the skin barrier, of which, the most widely used is that of chemical penetration enhancers.
- Terpenes found in the essential oils of plants, especially in conifers and citrus trees are used as penetration enhancers and are classified as Generally Regarded As Safe (GRAS) by the Food and Drug Administration.
- GRAS Generally Regarded As Safe
- Other known important uses of Eos are for antimicrobial and cancer treatments.
- Some of the EOs such as lemon oil and orange oil are a rich source of un-saturated fatty acids; oleic acid ( ⁇ -9), linoleic acid ( ⁇ -6) and linolenic acid ( ⁇ -3).
- Mammals have a limited ability to synthesize important long-chain ⁇ -3 fatty acids when the diet includes mainly shorter-chain ⁇ -3 fatty acids.
- the ability to make the longer-chain ⁇ -3 fatty acids may also be impaired in aging.
- the ratio between ingested fatty acids ⁇ -6 and the ⁇ -3 has significant influence on rate of production of eicosanoids, a group of hormones intimately involved in the body's inflammatory and homeostatic processes.
- ⁇ -9 fatty can be created by the human body from unsaturated fat and therefore not classified as essential in the diet.
- PFCs Perfluorinated oils or perfluorocarbons
- silicone based synthetic fluids that were first associated with the air conditioning industry.
- PFCs are characterized by: odorless, colorless, non-flammable, low viscosity, hydrocarbon free, short retention time in human body, high water and oil repellency and non-irritant. Those characteristics made the PFCs particularly suitable for skin care while providing good feel on use.
- Oxygenated perfluorocarbones administered in emulsions are known to increase surface oxygen concentration without the need for a pressure chamber.
- PFD Perfluorodecalin
- PFD is a PFC having lipophobic and hydrophobic characteristics that facilitates emulsions by formation of a third liquid phase.
- PFD is chemically and biologically inert and is capable of dissolving (or physically carry), relatively large amounts of gases. At 25°C 100 ml of PFD may dissolve 49 ml oxygen. Consequently, PFD is useful for various applications such as cell cultures growth, ulcers burns and skin treatments.
- the cosmetic topical cosmetic treatment formulation O 2 XEED includes: at least about 0.01 % to at most about 10% by weight lemon oil; at least about 0.01 % to at most about 10% by weight orange oil; at least about 0.01 % to at most about 10% by weight Inca inchi oil; at least about 0.01 % to at most about 10% by weight turmeric oil, and at least about 0.01 % to at most about 10% by weight perfluorodecalin.
- the cosmetic topical treatment formulation (termed O 2 XEED), can be incorporated into cosmetic preparations, including but not limited to: creams, soaps, lotions, body butters, gels, emulsions, solutions, impregnation sheets, tinctures, sprays, serums, masks or mousses.
- Limonene is one of the major components of citrus oils with concentrations from 88% to 95% of lemon or orange oil. Other components found in citrus fruit oils are Citral that has been highlighted as an active compound particularly against decay and Linalool terpene that may be important in any antimicrobial activity. Natural compound, derived from lemon oil extract may play a role in controlling free radical-induced lipid peroxidation and tissue damage in the skin.
- Sacha inchi (Plukenetia volubilisL), also named “Inca Peanut”, “wild peanut”, “Inca inchi” or “mountain peanut”, is a plant of the Euphorbiaceae family, which grows in the Amazonian forest. This plant, widely cultivated in Peru, has been a component of the diet of various native tribal groups of the region (Hamaker et al., 1992).
- Inca inchi Seeds of Inca inchi are of great interest due to their high oil content (35-60%) which contains elevated levels of ⁇ -3 and ⁇ -6 that reach about 45% and 35% of total fatty acids (FA), respectively.
- Other FA such as oleic, palmitic and stearic, are also present in minor proportions (Hamaker et al., 1992).
- Inca inchi oil also contains essential minerals such as magnesium calcium, and zinc.
- the tocopherols (vitamine E and derivatives) and Examponificables (campesterol, stigmasterol and beta sitosterole) that are found in Inca inchi oil may provide the skin improved microcirculation, free radicals scavanging as well as antioxidation protection.
- Curcuma longa Linn, or turmeric is a medicinal plant widely cultivated in tropical regions.
- the main bioactive component of turmeric is a yellow color pigment - the curcumin.
- the major constituents of the curcumeric oil are a-turmerone (44.1 %), ⁇ - turmerone (18.5%) and ar-turmerone (5.4%).
- In vitro experiments show similar activity of the curcumeric oil to vitamine E: improving microcirculation, oxygen free radicals scavanging and protection against oxidation of fats, oils and cellular organelles and structures.
- the antioxidant activity, (oxygen free radicals scavanging) of the curcumin inhibits damage in human keratinocytes and fibroblasts cells.
- the keratinocyte is the cell type that constitute 90% of the cells in the epidermis, the outermost layer of the skin.
- Fibroblasts are cells that synthesize the extracellular matrix and the collagen, the structural framework of human tissue that plays a critical role in wound healing. Fibroblasts are the most common cells in connective tissues that are found in the papilla at the base of the hair follicle.
- the cosmetic topical cosmetic treatment formulation O 2 XEED includes: at least about 0.01 % to at most about 10% by weight lemon oil; at least about 0.01 % to at most about 10% by weight orange oil; at least about 0.01 % to at most about 10% by weight Inca inchi oil; at least about 0.01 % to at most about 10% by weight turmeric oil, and at least about 0.01 % to at most about 10% by weight perfluorodecalin.
- the cosmetic topical skin treatment formulation O 2 XEED includes: about 0.5% by weight lemon oil; about 0.5% by weight orange oil; about 0.5% by weight Inca inchi; about 0.5% by weight turmeric oil, and about 1.0% by weight perfluorodecalin.
- the cosmetic topical treatment formulation (termed O 2 XEED), can be incorporated into cosmetic preparations, including but not limited to: creams, soaps, lotions, body butters, gels, emulsions, solutions, impregnation sheets, tinctures, sprays, serums, masks or mousses.
- a method of improving the appearance of the skin including applying to the skin a cosmetic topical treatment formulation including: lemon oil, orange oil, Inca inchi oil, turmeric oil and perfluorodecalin.
- a method of improving the appearance of the hair including applying to the hair a cosmetic topical treatment formulation including: lemon oil, orange oil, Inca inchi oil, turmeric oil and perfluorodecalin.
- a method of improving the appearance of the skin and hair including applying to cosmetic treatment formulation including: at least about 0.01 % to at most about 10% by weight lemon oil; at least about 0.01 % to at most about 10% by weight orange oil; at least about 0.01 % to at most about 10% by weight Inca Inchi oil; at least about 0.01 % to at most about 10% by weight turmeric oil, and at least about 0.01 % to at most about 10% by weight perfluorodecalin.
- a method of improving the appearance of the skin and hair including applying to cosmetic treatment formulation including: about 0.5% by weight lemon oil; about 0.5% by weight orange oil; about 0.5% by weight Inca inchi; about 0.5% by weight turmeric oil, and about 1 .0% by weight perfluorodecalin.
- each formulation contained only one component out of the five components: lemon oil, orange oil, Inca inchi oil, turmeric oil and perfluorodecaline in a respective concentration, namely either: about 0.5% by lemon oil; about 0.5% by weight orange oil; about 0.5% by weight Incalnca inchi oil; about 0.5% by weight turmeric oil, or about 1 .0% by weight perfluorodecaline.
- a blind test was conducted encompassing 200 volunteers, which were separated to five groups of 40 individuals each.
- the volunteers of each group treated their facial skin with a different formulation either: about 0.5% by weight lemon oil; about 0.5% by weight orange oil; about 0.5% by weight Inca inchi oil; about 0.5% by weight turmeric oil; about 1 .0% by weight perfluorodecaline, or about 3.0% by weight O2XEED.
- Each volunteer was asked to rank the effect of the composition on the following criteria of skin appearance: improvement in skin hydration; smoothness of wrinkles; reduction in skin visible pigment spots; better unified skin tone, and tight skin appearance revealing younger looking skin.
- Average ranks for each formulation are given in Table 2.
- Table 2 Average ranks of the effect of separate components of the cosmetic topical skin treatment formulation of the present invention on facial skin appearance criteria, compared to the effect of the cosmetic topical skin treatment formulation - O 2 XEED.
- a blind test was conducted with 200 volunteers, which were separated to five groups of 40 individuals each.
- the volunteers of each group treated their hair with a different formulation either: about 0.5% by weight lemon oil; about 0.5% by weight orange oil; about 0.5% by weight Inca inchi oil; about 0.5% by weight turmeric oil; about 1 .0% by weight perfluorodecaline, or about 3.0% by weight O 2 XEED.
- Each volunteer was asked to rank the effect of the composition on the following criteria of hair appearance: improvement of the texture and the soft touch of the hair; strengthens of the hair fibers resistance from roots to hair end; improvement in hair softness; better hair moisturization and hydretion, and enhancement of hair shine and brilliance. Average ranks for each formulation are given in Table 3.
- Table 3 Average ranks of the effect of separate components of the cosmetic hair treatment formulation of the present invention on hair appearance criteria, compared to the effect of the cosmetic topical skin treatment formulation - O 2 XEED.
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Abstract
The present invention relates to a cosmetic treatment formulation. The invention particularly relates to cosmetic treatment that includes a combination comprising at least: fluorocarbon oxygen carrier; citrus oils; Inca inchi oil, and turmeric oil. This combination had achieved a surprising synergistic effect on skin and on hair appearance when applied to the skin and to the hair. Volunteers who used the above mentioned combination have rated its effect substantially higher compared to using each component of the combination when used separately and also compared to the sum of the results achieved by using each component separately.
Description
COSMETIC TOPICAL SKIN AND HAIR TREATMENT
FORMULATION
CROSS-REFERENCE TO RELATED APPLICATIONS [001 ] The present application claims the benefit of priority to an Israeli
Patent Application Serial Number 236521 , filed August 5, 2005, entitled "Cosmetic Topical Skin and Hair Treatment Formulation." The aforementioned application is hereby incorporated herein by reference.
TECHNICAL FIELD
[002] The present invention relates to a cosmetic treatment formulation. The invention particularly relates to cosmetic treatment including a combination of oils and an oxygen carrier.
BACKGROUND ART
[003] Skin is the soft outer covering of vertebrates. In mammals the skin guards the underlying muscles, bones, ligaments and internal organs. Mammals may have also some hair on their skin. The skin is one of the most important organs of the body because it interfaces with the environment and is the first line
of defense from external factors. For example, the skin plays a key role in protecting the body against pathogens and excessive water loss. Other functions of the skin include insulation, temperature regulation and sensation.
[004] In humans and other mammals, the skin has three layers - the epidermis, the dermis and the subcutis (or hypodermis). The epidermis forms the surface of the skin. It is made up of several layers of cells called keratinocytes. The dermis lies underneath the epidermis and contains skin appendages: hair follicles, sebaceous (oil) glands and sweat glands. The subcutis contains fat cells and some sweat glands. The protective barrier of the skin is the hydrolipidic film, also known as the skin barrier, which contains aqueous substances and oils produced by the sebaceous glands. The function of the skin barrier is to retain moisture, protect against the entrance of germs and fungi into the skin and protect against UV radiation - a leading cause of premature aging signs. An intact skin barrier maintains the skin's natural suppleness.
[005] In young skin, the epidermis fully renews itself approximately every 4 weeks. This process continuously slows during aging. The number of skin stem cells decreases and their vitality diminishes. Excessive UV exposure of the skin and an unhealthy lifestyle (smoking, alcohol) aggravate these effects considerably, resulting in thinner, more deeply wrinkled skin. The hydrolipidic
film is reduced, which leaves the skin dryer and less well protected. As no new epidermal stem cells can develop during life, it is important to maintain the vitality of the skin stem cells and their ability to divide as long as possible.
[006] During everyday life the skin is exposed to chemicals like soap and to physical stresses like friction with clothes or exposure to sunlight. The epidermis and skin appendages need to be renewed constantly to keep the skin in good condition. In addition, if the skin is cut or damaged, it has to be able to be repaired efficiently in order to keep protecting the body from the environment.
[007] Oxygen is used by skin cells to produce energy to fuel cellular processes such as proliferation and production of extracellular matrix substances both which are essential for maintaining healthy, young looking skin. Oxygen levels in the skin are lower than other parts of the body and are known to decrease further with age.
[008] Care of the hair and care of the scalp skin may appear separate, but are actually intertwined because hair grows from beneath the skin. The living parts of hair (hair follicle, hair root, root sheath, and sebaceous gland) are beneath the skin, while the actual hair shaft which emerges (the cuticle which covers the cortex and medulla) has no living processes. If the scalp is not cleaned regularly, by the removal of dead skin cells, toxins released through the skin or external hazards (such as bacteria, viruses, and chemicals) may create a
breeding ground for infection. The sebaceous glands in human skin produce sebum, which is composed primarily of fatty acids. Sebum acts to protect hair and skin, and can inhibit the growth of microorganisms on the skin. Sebum contributes to the skin's slightly acidic natural pH somewhere between 5 and 6.8 on the pH spectrum. This oily substance gives hair moisture and shine as it travels naturally down the hair shaft, and serves as a protective substance preventing the hair from drying out or absorbing excessive amounts of external substances.
[009] Hair follicles are the mammalian skin organ that produces hair. The hair follicle includes papilla which is a large structure at the base of the hair follicle made up mainly of connective tissue and a capillary loop. Around the papilla is the hair matrix, a collection of epithelial cells often interspersed with pigment-producing cells. Cell division in the hair matrix produces the cells that form the major structures of the hair fiber and the inner root sheath. The hair matrix epithelium is one of the fastest growing cell populations in the human body. The root sheath is composed of an external and internal root sheath. The internal root sheath is composed of three layers where the internal cuticle layer is continuous with the outermost layer of the hair fiber. The bulge is located in the outer root sheath and houses several types of stem cells that are supplied to the hair follicle. The hair follicle stem cells are responsible for hair production as well as regeneration of the epidermis and sebaceous glands. Other structures
associated with the hair follicle include the cup in which the follicle grows known as the infundibulum, the arrector pili muscles, the sebaceous glands, and the apocrine sweat glands. Hair follicle receptors sense the position of the hair. Each arrector pili is composed of bundle of smooth muscle fibers which are attached to several follicles (a follicular unit) and are innervated by the sympathetic branch of the autonomic nervous system. The contraction of the muscle is therefore involuntary. Stresses such as cold, fear etc. may stimulate the sympathetic nervous system and thus cause temporarily contraction. The sebaceous glands are microscopic exocrine glands in the skin that secrete an oily or waxy matter, called sebum that lubricates and waterproof the skin and hair.
[010] Essential oils (EOs) are extracts of plants that have been screened for their potential uses as being source of biologically active compounds. The greatest obstacle for trans-dermal delivery is the barrier property of the stratum corneum. Many approaches have been employed to breach the skin barrier, of which, the most widely used is that of chemical penetration enhancers. Terpenes found in the essential oils of plants, especially in conifers and citrus trees are used as penetration enhancers and are classified as Generally Regarded As Safe (GRAS) by the Food and Drug Administration. Other known important uses of Eos are for antimicrobial and cancer treatments.
[01 1 ] Some of the EOs such as lemon oil and orange oil are a rich source of un-saturated fatty acids; oleic acid (ω-9), linoleic acid (ω-6) and linolenic acid (ω-3). Mammals have a limited ability to synthesize important long-chain ω-3 fatty acids when the diet includes mainly shorter-chain ω-3 fatty acids. The ability to make the longer-chain ω-3 fatty acids may also be impaired in aging. The ratio between ingested fatty acids ω-6 and the ω -3 has significant influence on rate of production of eicosanoids, a group of hormones intimately involved in the body's inflammatory and homeostatic processes. Unlike ω-3 f and ω-6 fatty acids, ω-9 fatty can be created by the human body from unsaturated fat and therefore not classified as essential in the diet.
[012] Perfluorinated oils or perfluorocarbons (PFCs) are silicone based synthetic fluids that were first associated with the air conditioning industry. PFCs are characterized by: odorless, colorless, non-flammable, low viscosity, hydrocarbon free, short retention time in human body, high water and oil repellency and non-irritant. Those characteristics made the PFCs particularly suitable for skin care while providing good feel on use. Oxygenated perfluorocarbones administered in emulsions are known to increase surface oxygen concentration without the need for a pressure chamber.
[013] Perfluorodecalin (PFD), is a PFC having lipophobic and hydrophobic characteristics that facilitates emulsions by formation of a third liquid phase. PFD
is chemically and biologically inert and is capable of dissolving (or physically carry), relatively large amounts of gases. At 25°C 100 ml of PFD may dissolve 49 ml oxygen. Consequently, PFD is useful for various applications such as cell cultures growth, ulcers burns and skin treatments.
SUMMARY OF THE INVENTION
[014] To our surprising we realized that a formulation including a combination of lemon oil, orange oil, Inca inchi oil, turmeric oil and perfluorodecalin has a synergistic effect on skin and on hair appearance when applied to the skin and to the hair.
[015] In accordance with one embodiment of the present invention the cosmetic topical cosmetic treatment formulation O2XEED includes: at least about 0.01 % to at most about 10% by weight lemon oil; at least about 0.01 % to at most about 10% by weight orange oil; at least about 0.01 % to at most about 10% by weight Inca inchi oil; at least about 0.01 % to at most about 10% by weight turmeric oil, and at least about 0.01 % to at most about 10% by weight perfluorodecalin.
[016] In accordance with yet another embodiment of the present invention, the cosmetic topical treatment formulation, (termed O2XEED), can be
incorporated into cosmetic preparations, including but not limited to: creams, soaps, lotions, body butters, gels, emulsions, solutions, impregnation sheets, tinctures, sprays, serums, masks or mousses.
DISCLOSURE OF THE INVENTION
[017] Illustrative embodiments of the invention are described below. In the interest of clarity, not all features/components of an actual implementation are necessarily described.
Composition of the Cosmetic Treatment Formulation [018] Limonene is one of the major components of citrus oils with concentrations from 88% to 95% of lemon or orange oil. Other components found in citrus fruit oils are Citral that has been highlighted as an active compound particularly against decay and Linalool terpene that may be important in any antimicrobial activity. Natural compound, derived from lemon oil extract may play a role in controlling free radical-induced lipid peroxidation and tissue damage in the skin.
Apart for limonene being the dominant ingredient in orange oil (greater than 90%), a second important group of substances includes long chain aliphatic hydrocarbon alcohols and aldehydes like 1 -octanol and octanal.
[019] Sacha inchi (Plukenetia volubilisL), also named "Inca Peanut", "wild peanut", "Inca inchi" or "mountain peanut", is a plant of the Euphorbiaceae family, which grows in the Amazonian forest. This plant, widely cultivated in Peru, has been a component of the diet of various native tribal groups of the region (Hamaker et al., 1992). Seeds of Inca inchi are of great interest due to their high oil content (35-60%) which contains elevated levels of ω-3 and ω-6 that reach about 45% and 35% of total fatty acids (FA), respectively. Other FA such as oleic, palmitic and stearic, are also present in minor proportions (Hamaker et al., 1992). Inca inchi oil also contains essential minerals such as magnesium calcium, and zinc. The tocopherols (vitamine E and derivatives) and insaponificables (campesterol, stigmasterol and beta sitosterole) that are found in Inca inchi oil may provide the skin improved microcirculation, free radicals scavanging as well as antioxidation protection.
[020] The high content of fatty acids ω-3, ω-6 and ω-9 that are found in lemon oil, orange oil and Inca Inchi oil are listed below in table 1 :
Insaturated acids fatty contents in lemon oil, orange oil and Inca inchi
[021 ] The synergic effect of the use of a composition comprising ω-3, ω-6 and ω-9 may lead to the following benefitial results in skin treatment: limitation of Trans Epidermal Water Loss (TEWL), maitaining elasticity, enhancing transcutaneous flux and oxygen incorporation.
[022] Curcuma longa Linn, or turmeric (Zingiberaceae) is a medicinal plant widely cultivated in tropical regions. The main bioactive component of turmeric is a yellow color pigment - the curcumin. The major constituents of the curcumeric oil are a-turmerone (44.1 %), β- turmerone (18.5%) and ar-turmerone (5.4%). In vitro experiments show similar activity of the curcumeric oil to vitamine E: improving microcirculation, oxygen free radicals scavanging and protection against oxidation of fats, oils and cellular organelles and structures.
The antioxidant activity, (oxygen free radicals scavanging), of the curcumin inhibits damage in human keratinocytes and fibroblasts cells. The keratinocyte is the cell type that constitute 90% of the cells in the epidermis, the outermost layer of the skin. Fibroblasts are cells that synthesize the extracellular matrix and the collagen, the structural framework of human tissue that plays a critical role in wound healing. Fibroblasts are the most common cells in connective tissues that are found in the papilla at the base of the hair follicle.
[023] To our surprising we realized that a formulation including a combination of lemon oil, orange oil, Inca inchi oil, turmeric oil and perfluorodecalin has a synergistic effect on skin and on hair appearance when applied to the skin and to the hair. The trade name we have given to this formulation is O2XEED.
[024] In accordance with one embodiment of the present invention the cosmetic topical cosmetic treatment formulation O2XEED includes: at least about 0.01 % to at most about 10% by weight lemon oil; at least about 0.01 % to at most about 10% by weight orange oil; at least about 0.01 % to at most about 10% by weight Inca inchi oil; at least about 0.01 % to at most about 10% by weight turmeric oil, and at least about 0.01 % to at most about 10% by weight perfluorodecalin.
[025] In accordance with another embodiment of the present invention the cosmetic topical skin treatment formulation O2XEED includes: about 0.5% by weight lemon oil; about 0.5% by weight orange oil; about 0.5% by weight Inca inchi; about 0.5% by weight turmeric oil, and about 1.0% by weight perfluorodecalin.
[026] In accordance with yet another embodiment of the present invention, the cosmetic topical treatment formulation, (termed O2XEED), can be incorporated into cosmetic preparations, including but not limited to: creams, soaps, lotions, body butters, gels, emulsions, solutions, impregnation sheets, tinctures, sprays, serums, masks or mousses.
Method of usage
[027] In one embodiment of the present invention there is provided a method of improving the appearance of the skin including applying to the skin a cosmetic topical treatment formulation including: lemon oil, orange oil, Inca inchi oil, turmeric oil and perfluorodecalin.
[028] In another embodiment of the present invention there is provided a method of improving the appearance of the hair including applying to the hair a cosmetic topical treatment formulation including: lemon oil, orange oil, Inca inchi oil, turmeric oil and perfluorodecalin.
[029] In another embodiment of the present invention there is provided a method of improving the appearance of the skin and hair including applying to cosmetic treatment formulation including: at least about 0.01 % to at most about 10% by weight lemon oil; at least about 0.01 % to at most about 10% by weight orange oil; at least about 0.01 % to at most about 10% by weight Inca Inchi oil; at least about 0.01 % to at most about 10% by weight turmeric oil, and at least about 0.01 % to at most about 10% by weight perfluorodecalin.
[030] In another embodiment of the present invention there is provided a method of improving the appearance of the skin and hair including applying to cosmetic treatment formulation including: about 0.5% by weight lemon oil; about 0.5% by weight orange oil; about 0.5% by weight Inca inchi; about 0.5% by weight turmeric oil, and about 1 .0% by weight perfluorodecalin.
Synergistic effect
[031 ] In order to evaluate the effect of the cosmetic topical skin treatment formulation the invention, formulations were manufactured, in which each formulation contained only one component out of the five components: lemon oil, orange oil, Inca inchi oil, turmeric oil and perfluorodecaline in a respective concentration, namely either: about 0.5% by lemon oil; about 0.5% by weight orange oil; about 0.5% by weight Incalnca inchi oil; about 0.5% by weight turmeric oil, or about 1 .0% by weight perfluorodecaline.
[032] A blind test was conducted encompassing 200 volunteers, which were separated to five groups of 40 individuals each. The volunteers of each group treated their facial skin with a different formulation either: about 0.5% by weight lemon oil; about 0.5% by weight orange oil; about 0.5% by weight Inca inchi oil; about 0.5% by weight turmeric oil; about 1 .0% by weight perfluorodecaline, or about 3.0% by weight O2XEED. Each volunteer was asked to rank the effect of the composition on the following criteria of skin appearance: improvement in skin hydration; smoothness of wrinkles; reduction in skin visible pigment spots; better unified skin tone, and tight skin appearance revealing younger looking skin. Average ranks for each formulation are given in Table 2.
Table 2: Average ranks of the effect of separate components of the cosmetic topical skin treatment formulation of the present invention on facial skin appearance criteria, compared to the effect of the cosmetic topical skin treatment formulation - O2XEED.
* Computed sum of volunteers' ranking results achieved by using each component separately (0.5% lemon oil, 0.5% orange oil, 0.5% Inca inchi oil, 0.5% turmeric oil or 1% perfluorodecalin)
[033] As can be seen in Table 2, volunteers who treated their facial skin with O2XEED rated its effect vis-a-vis the five skin appearance criteria in
substantially higher ranks than the ranks they gave to effects achieved by using each component separately and also compared to the sum of the results achieved by using each component separately, thus emphasizing the synergistic effect on skin appearance of the cosmetic topical skin treatment formulation of the present invention.
[034] A blind test was conducted with 200 volunteers, which were separated to five groups of 40 individuals each. The volunteers of each group treated their hair with a different formulation either: about 0.5% by weight lemon oil; about 0.5% by weight orange oil; about 0.5% by weight Inca inchi oil; about 0.5% by weight turmeric oil; about 1 .0% by weight perfluorodecaline, or about 3.0% by weight O2XEED. Each volunteer was asked to rank the effect of the composition on the following criteria of hair appearance: improvement of the texture and the soft touch of the hair; strengthens of the hair fibers resistance from roots to hair end; improvement in hair softness; better hair moisturization and hydretion, and enhancement of hair shine and brilliance. Average ranks for each formulation are given in Table 3.
Table 3: Average ranks of the effect of separate components of the cosmetic hair treatment formulation of the present invention on hair appearance criteria, compared to the effect of the cosmetic topical skin treatment formulation - O2XEED.
* Computed sum of results achieved by using each component separately as reflected by volunteers' ranking
(0.5% lemon oil, 0.5% orange oil, 0.5% Inca inchi oil, 0.5% turmeric oil or 1% perfluorodecalin)
[035] As can be seen in Table 3, volunteers who treated their hair with O2XEED rated its effect vis-a-vis the five hair appearance criteria in substantially
higher ranks than the ranks they gave to effects achieved by using each component separately and also compared to the sum of the results achieved by using each component separately, thus emphasizing the synergistic effect on hair appearance of the cosmetic topical hair treatment formulation of the present invention.
[036] It should be understood that the above description is merely exemplary and that there are various embodiments of the present invention that may be devised, mutatis mutandis, and that the features described in the above- described embodiments, and those not described herein, may be used separately or in any suitable combination; and the invention can be devised in accordance with embodiments not necessarily described above.
Claims
A cosmetic treatment formulation comprising at least:
• fluorocarbon oxygen carrier;
• citrus oils;
• Inca inchi oil, and
• turmeric oil.
A cosmetic treatment formulation as in claim 1 , wherein said oxygen carrier is perfluorodecalin.
A cosmetic treatment formulation as in claim 2, wherein said citrus oils are lemon oil and orange oil.
The formulation according to claim 3, wherein: the perfluorodecalin comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation; the lemon oil comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation; the orange oil comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation; the Inca inchi oil comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation; the turmeric oil comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation;
the perfluorodecalin comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation.
The formulation according to claim 3, wherein: the lemon oil comprises about 0.5% by weight of the cosmetic treatment formulation; the orange oil comprises about 0.5% by weight of the cosmetic treatment formulation; the Inca inchi oil comprises about 0.5% by weight of the cosmetic treatment formulation; the turmeric oil comprises about 0.5% by weight of the cosmetic treatment formulation; the perflurorodeclain comprises about 1 .0% by weight of the cosmetic treatment formulation.
The cosmetic treatment formulation according to claim 3, wherein the formulation is in the form of a cream, soap, lotion, body butter, gel, emulsion, solution, impregnation sheet, tincture, spray, serum, mask or mousse.
7. A method of improving the appearance of the skin comprising applying to the skin a cosmetic topical skin treatment formulation comprising: perfluorodecalin, lemon oil, orange oil, inca inchi oil and turmeric oil
8. The method according to claim 7, wherein: the perfluorodecalin comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation; the lemon oil comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation; the orange oil comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation; the inca inchi oil comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation; the turmeric oil comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation; the perfluorodecalin comprises at least about 0.1 % to at most about 10% by weight of the cosmetic treatment formulation.
9. The method according to claim 7, wherein: the lemon oil comprises about 0.5% by weight of the cosmetic treatment formulation; the orange oil comprises about 0.5% by weight of the cosmetic treatment formulation; the inca inchi oil comprises about 0.5% by weight of the cosmetic treatment formulation; the turmeric oil comprises about 0.5% by weight of the cosmetic treatment formulation; the perflurorodeclain comprises about 1 .0% by weight of the cosmetic treatment formulation.
10. The method according to claim 7, wherein: wherein the formulation is in the form of a cream, soap, lotion, body butter, gel, emulsion, solution, impregnation sheet, tincture, spray, serum, mask or mousse.
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