CN110613632A - Pet washing and caring composition rich in hyaluronic acid or salt thereof and preparation method thereof - Google Patents
Pet washing and caring composition rich in hyaluronic acid or salt thereof and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/002—Preparations for repairing the hair, e.g. hair cure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
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Abstract
The invention discloses a pet washing and caring composition rich in hyaluronic acid or salt thereof, which comprises the following raw materials: hyaluronic acid or its salt composition, oil, microcapsule essential oil, and amino acid surfactant. The invention also relates to a preparation method of the pet washing and caring composition. The application provides a pet washing and caring composition rich in hyaluronic acid or salt thereof, which has the effects of convenient and safe use, moisture retention, hair softening, mite removal, sterilization, fishy smell removal and fragrance retention.
Description
Technical Field
The application relates to the technical field of daily necessities for pets, and more particularly relates to a pet washing and caring composition rich in hyaluronic acid or hyaluronic acid salt and a preparation method thereof.
Background
At present, more and more people are raising pets, and the pets gradually become one member of families. The pet cat and dog has thick and dense hair, poor air permeability and difficult hair cleaning, and the skin of the pet cat and dog can secrete various substances, so that good survival conditions are provided for various parasites, various bacteria, fungi and the like. These parasites and pathogens not only harm the healthy growth of pets, cause various skin diseases, but also even cross-spread and infection of diseases of humans and animals, and harm the safety and health of humans and pets.
Effective daily care and prophylactic treatment of skin diseases in pets is an important issue facing pet enthusiasts. In veterinary clinics, mite and fungal infections are causal to each other, often mixed infections. To avoid mixed infections, precautions need to be taken. The ideal pet bath product has certain functions of cleaning and degreasing, can form fine and stable foam, has the advantages of luster, softness and restoration, small irritation and good taste covering effect on pet fur after bath, and has the effects of preventing the mite and fungal infection of pets and treating.
At present, pet bath articles in the market are various, for example, patent CN201810120430 discloses a special bath foam for pets, which comprises the following components in parts by weight: phase A: 90-100 parts of deionized water, 1.0-3.0 parts of acrylate, 16.0-20.0 parts of sodium laureth sulfate, 1.0-2.0 parts of ethylene glycol distearate and 0.6-1.0 part of cocamide MEA; phase B: polyquaternium-100.15-0.23 part, guar gum hydroxypropyl trimethyl ammonium chloride 0.1-0.3 part, dicocoyl ethyl hydroxyethyl methyl ammonium methyl sulfate 0.4-0.7 part, cocamidopropyl betaine 4.0-7.0 part, olive oil PEG-7 esters 0.7-2.0 part, sodium chloride 1.0-2.0 part, and phase C: 1.0-3.0 parts of polydimethylsiloxane, 1.0-3.0 parts of dimethiconol, 0.3-1.0 part of ammonia-terminated polydimethylsiloxane, 4.0-6.5 parts of mink oil, 0.2-0.4 part of DMDM hydantoin, 0.5-0.7 part of triclosan, 2.0-3.0 parts of triethanolamine (99%) and 0.15-0.3 part of essence, and has the functions of moistening, repairing, fluffing, sterilizing and expelling parasites. CN201611130687 discloses a tearless bath lotion for pet dog, which contains natural essence such as herba Menthae and folium Neocinnamomi Delavayi, and has unique fragrance without irritation to pet dog, and can relieve anxiety of pet dog and facilitate bathing of pet dog; the Chinese medicines such as honeycomb and golden larch bark are added, so that the mosquito-repellent incense can achieve the effects of repelling mosquitoes and expelling worms while disinfecting and relieving itching. However, the pet washing and caring products in the prior art and the patents have the problem of short fragrance retention time, and the long-term insect expelling effect is difficult to achieve.
Disclosure of Invention
The present application is proposed to solve the above-mentioned technical problems. Embodiments of the present application provide a pet care composition rich in hyaluronic acid or a salt thereof and a method of preparing the same; the pet washing and caring composition rich in hyaluronic acid or its salt has the effects of convenient and safe use, moisture retention, hair softening, mite removal, sterilization, fishy smell removal and fragrance retention.
In order to achieve the purpose, the invention adopts the following technical scheme.
1. A pet washing and caring composition rich in hyaluronic acid or salt thereof comprises the following raw materials: hyaluronic acid or its salt composition, oil, microcapsule essential oil and amino acid surfactant.
2. The pet care composition rich in hyaluronic acid or a salt thereof according to item 1, comprising hyaluronic acid or a salt thereof having a molecular weight of not more than 10kDa, hyaluronic acid or a salt thereof having a molecular weight of 100kDa to 800kDa, a crosslinked polymer of hyaluronic acid or a salt thereof, and high-affinity hyaluronic acid or a salt thereof.
3. The pet care composition rich in hyaluronic acid or a salt thereof according to item 2, wherein the high-affinity hyaluronic acid or a salt thereof is obtained by complexing cationic guar and hyaluronic acid or a salt thereof in a polyol, the hyaluronic acid or a salt thereof is one or more of hyaluronic acid with a molecular weight of 3kDa to 2000kDa, the cationic guar has a molecular weight of 100kDa to 2000kDa, and the mass ratio of hyaluronic acid to cationic guar is 1: (0.01-100).
4. The pet care composition rich in hyaluronic acid or a salt thereof according to any of claims 1-3, wherein the content of the hyaluronic acid or a salt thereof composition is 0.01-42 parts, preferably 0.1-20 parts, and more preferably 0.6-15 parts, based on 100 parts by weight of the total composition.
5. The pet care composition rich in hyaluronic acid or a salt thereof according to any of claims 1 to 3, wherein hyaluronic acid or a salt thereof having a molecular weight of not more than 10kDa is 0 to 3%, preferably 0.05 to 2%, more preferably 0.1 to 1% in the hyaluronic acid or a salt thereof composition; hyaluronic acid or salt thereof with molecular weight of 100 KDa-800 KDa accounts for 0-5%, preferably 1.0-2.0%; 0 to 10.0%, preferably 0.01 to 5.0% of hyaluronic acid or a salt cross-linked polymer thereof; and 77-100%, preferably 92-99% of high-affinity hyaluronic acid or a salt thereof.
6. The pet care composition rich in hyaluronic acid or salt thereof, wherein the oil is selected from one or more of mineral oil, vegetable oil and animal oil; preferably one or more of natural source oils and fats such as olive oil, shea butter, coconut oil, castor oil, almond oil, peanut oil, soybean oil, palm oil, avocado oil, etc.
7. The pet care composition enriched in hyaluronic acid or salt thereof of item 6, wherein said oil is olive oil PEG-7 esters.
8. The pet care composition rich in hyaluronic acid or a salt thereof according to item 6, wherein the amount of the oil is 0.1 to 10 parts, preferably 2 to 6 parts, per 100 parts by weight of the total composition.
9. The pet washing and caring composition rich in hyaluronic acid or salt thereof according to item 1, wherein the hyaluronic acid microcapsule essential oil is 0-10 parts, preferably 1-6 parts, relative to 100 parts of the total weight of the composition.
10. The pet care composition enriched in hyaluronic acid or salt thereof of item 9, wherein the microencapsulated essential oil is microencapsulated slow-release tea tree essential oil.
11. The pet care composition rich in hyaluronic acid or a salt thereof according to item 1, wherein the amino acid surfactant is 0.01 to 70 parts by weight, preferably 4 to 30 parts by weight, based on 100 parts by weight of the total composition.
12. The pet wash composition enriched in hyaluronic acid or salt thereof of claim 11, wherein said amino acid surfactant is selected from one or more of potassium cocoyl glutamate, sodium lauroyl glutamate, sodium cocoyl glycinate.
13. The pet care composition rich in hyaluronic acid or a salt thereof according to item 1, further comprising a plant extract and water, wherein the plant extract accounts for 0.01-30 parts, preferably 1-15 parts, relative to 100 parts by weight of the total composition; the balance of water.
14. The pet care composition enriched in hyaluronic acid or salt thereof of item 13, wherein the plant extract is selected from one or more of lavender extract, jasmine extract, rose extract, chamomile extract, honeysuckle extract, licorice extract, tea tree extract, citronella extract, mint extract, vernonia galamensis extract, and the like.
15. A method of preparing a pet care composition enriched in hyaluronic acid or a salt thereof, comprising:
adding water into hyaluronic acid or its salt composition, and stirring to obtain a first mixture;
adding an amino acid surfactant into the first mixture, and uniformly stirring to obtain a second mixture;
adding the plant extract into the second mixture, and uniformly stirring to obtain a third mixture;
adding the microcapsule essential oil into the third mixture, and uniformly stirring to obtain a fourth mixture;
adding grease into the fourth mixture, and uniformly stirring to obtain a fifth mixture;
adding water into the fifth mixture, and uniformly stirring to obtain the pet cleaning and caring composition rich in hyaluronic acid or its salt.
The pet washing and protecting composition rich in hyaluronic acid or hyaluronic acid salt utilizes the characteristics of hyaluronic acid or hyaluronic acid salt, hyaluronic acid salt derivative and amino acid surface activity, can mildly clean fur of pet cats and dogs, can improve the skin state of pets, maintain stable physiological functions of skin, enhance skin immunity and resistance, has the characteristics of moisturizing, moistening and softening hair, is added with microcapsule essential oil with a slow release effect, has good functions of killing insects, sterilizing and removing fishy smell and fragrance, and can greatly prolong the fragrance retention time.
Detailed description of the invention
The invention provides a pet washing and caring composition rich in hyaluronic acid or salt thereof, which comprises the following raw materials: hyaluronic acid or its salt composition, oil, microcapsule essential oil and amino acid surfactant.
Hyaluronic acid or its salt (HA) is an important component of human and animal skin, vitreous, joint lubricating fluid and cartilage tissue. The molecular formula is (C)14H21NO11) N, which is formed by repeating the connection of (1-beta-4) D-glucuronic acid and (1-beta-3) N-acetyl-D-glucosamine disaccharide units, and the polymer thereof is in vivoMolecular weights ranging from 5000 to 2000 kilodaltons are considered to be polysaccharides that fill spaces, stabilize structures, coat cells and protect cells. The amino acid surfactant is mild and non-irritant, and can be used for cleaning the surface fur of the pet, when the amino acid surfactant is used for cleaning the surface fur of the pet, a certain amount of grease is added to achieve a certain nourishing and caring effect on the skin and hair of the pet, the microcapsule essential oil can keep faint scent and has long-term anti-inflammation and insect-repelling effects on the fur of the pet, and the plant extract is non-toxic and non-irritant and has good anti-inflammation and sterilization effects. Therefore, the pet washing and protecting composition disclosed by the invention can mildly clean the fur of pet cats and dogs, can improve the skin state of pets, maintain the stable physiological function of skin, enhance the immunity and resistance of skin, has the characteristics of moisturizing, moistening and softening hair, is added with the microcapsule essential oil with a slow release effect, and also has good insecticidal and sterilization, fishy smell removal and fragrance retention effects.
The hyaluronic acid or a salt thereof composition of the present invention comprises: hyaluronic acid or a salt thereof having a molecular weight of not more than 10kDa, hyaluronic acid or a salt thereof having a molecular weight of 100kDa to 800kDa, a crosslinked polymer of hyaluronic acid or a salt thereof, and high-affinity hyaluronic acid or a salt thereof. Hyaluronic acid or its salt with molecular weight not more than 10KDa can penetrate into dermis, has effects of slightly dilating capillary, increasing blood circulation, improving middle metabolism, promoting skin nutrition absorption, removing wrinkle, increasing skin elasticity, delaying skin aging, promoting proliferation and differentiation of epidermal cell, scavenging oxygen free radical, and preventing and repairing skin injury. Hyaluronic acid or its salt is one of skin constituents, is widely distributed acidic mucopolysaccharide, exists in connective tissue matrix, and has good moisturizing effect; it can be used in cosmetic such as cream, honey, milk, facial mask, shampoo, etc. for keeping moisture of skin and hair, moistening skin and hair, increasing luster, and preventing chapped skin and wrinkle. The hyaluronic acid or the salt thereof with the molecular weight of 100 KDa-800 KDa has better viscoelasticity, moisture retention, inflammatory reaction inhibition and the like. The hyaluronic acid or salt crosslinked polymer is a polymer gel with a three-dimensional structure, which is obtained by crosslinking and modifying hyaluronic acid or salt thereof, can make up for the defects of short retention time and the like of hyaluronic acid or salt thereof, and has good biocompatibility and effect. The high-affinity hyaluronic acid or the salt thereof has good conditioning and smoothing effects on pet hair, has affinity to living tissues (such as hair, skin and the like), enables hyaluronic acid or the salt thereof to be easily adsorbed to the skin or the hair, plays the efficacy of moisturizing and caring the skin or the hair, and can prolong the residence time of hyaluronic acid or the salt thereof on the skin surface and the hair surface of the pet.
In one embodiment of the present invention, the content of the hyaluronic acid or salt composition is 0.01 to 42 parts, preferably 0.1 to 20 parts, and more preferably 0.6 to 15 parts, based on 100 parts by weight of the total composition.
In one embodiment of the present invention, the content of hyaluronic acid or a salt thereof having a molecular weight of not more than 10KDa in the hyaluronic acid or a salt thereof composition is 0 to 3%, preferably 0.05 to 2%, and more preferably 0.1 to 1% with respect to 100 parts by weight of the total composition; hyaluronic acid or salt thereof with molecular weight of 100 KDa-800 KDa accounts for 0-5%, preferably 1.0-2.0%; 0 to 10.0%, preferably 0.01 to 5.0% of hyaluronic acid or a salt cross-linked polymer thereof; and 77-100%, preferably 92-99% of high-affinity hyaluronic acid or a salt thereof.
The hyaluronic acid or salt thereof crosslinked polymer is formed by polymerizing hyaluronic acid or salt thereof through a crosslinking agent to form a macromolecular crosslinked polymer. Specific forms thereof include aqueous solutions, hydrogels and solid powders. The molecular weight of the hyaluronic acid or the salt thereof is used to cover all molecular weight sections of the hyaluronic acid or the salt thereof.
The high-affinity hyaluronic acid or the salt thereof is obtained by complexing cationic guar gum and hyaluronic acid or the salt thereof in polyhydric alcohol, the hyaluronic acid or the salt thereof is one or more of hyaluronic acid with the molecular weight of 3kDa-2000kDa and the salt thereof, the molecular weight of the cationic guar gum is 100kDa-2000kDa, and the mass ratio of the hyaluronic acid to the cationic guar gum is 1: (0.01-100).
In one embodiment of the present invention, the oil is selected from one of mineral oil, vegetable oil and animal oil, preferably one or more of olive oil, shea butter, coconut oil, castor oil, almond oil, peanut oil, soybean oil and palm oil; more preferably, the oil and fat is selected from one or two of olive oil and almond oil, and further preferably, the oil and fat is olive oil PEG-7 esters. Mineral oil generally refers to crude oil (or petroleum) which is mined and primarily processed, the mineral oil is a natural mineral product buried underground, and the petroleum which is explored and mined and is not refined is also called crude oil. Vegetable oil is a compound obtained by combining unsaturated fatty acid and glycerin, is widely distributed in nature, and is oil obtained from fruits, seeds, and germs of plants. Such as peanut oil, soybean oil, linseed oil, castor oil, rapeseed oil, and the like. The main component of vegetable oil is ester of straight chain higher fatty acid and glycerol, and the fatty acid contains various unsaturated acids such as erucic acid, eleostearic acid, ricinoleic acid, etc. in addition to palmitic acid, stearic acid and oleic acid. The vegetable oil mainly contains vitamin E, K, minerals such as calcium, iron, phosphorus, potassium, etc., and fatty acid. The fatty acid in the vegetable oil can moisten and luster the skin. Animal oils are fats of animals, as opposed to vegetable oils, i.e., animal fats and oils. The olive oil is prepared by directly cold pressing fresh olive fruits, and retains natural nutritional components without heating and chemical treatment. The olive oil is rich in squalene with excellent affinity with skin and fatty acid necessary for pets, is quickly absorbed, and can effectively keep skin elasticity and moistening; the olive oil is rich in monounsaturated fatty acid, vitamin E, K, A, D, etc., and phenolic antioxidant substances, and has effects of eliminating skin wrinkle, preventing skin aging, caring skin and hair, and preventing chap. The extraction of shea butter is from shea butter, which is a plant with magical maintenance function; is pure natural green plant source solid oil, can promote epidermal cell regeneration, and has skin nutrition effect. The olive oil PEG-7 esters are used in washing and caring products, have no toxicity or irritation, have certain moisturizing effect on skin and hair, and can enhance the moisture adsorption capacity of skin stratum corneum, thereby preventing excessive dryness of skin and hair, and being a natural skin and hair caring substance. The shea butter is relatively close to each index of sebum secretion oil of pets, contains rich non-saponification components, is easy to be absorbed by the pets, can prevent drying and cracking, further recovers and maintains the natural elasticity of skin, and has the function of diminishing inflammation. Coconut oil, is the endosperm of the palm plant coconut, and is extracted after grinding and drying. Coconut oil is white liquid in tropical places and is a beef tallow-like solid in cold places; has special smell and fragrant smell when fresh. Coconut oil has strong cleaning effect, can clean dirt in skin, is organic, natural and pure fresh coconut oil, absolutely does not hurt skin, can be used for makeup removal and cleaning, and can protect the skin from being damaged by ultraviolet rays after being externally applied. And the pure fresh coconut oil is the only oil which can reduce the loss of hair protein, and can make the hair of the pet smooth. Castor oil is triglyceride of fatty acid, and is obtained by squeezing or solvent extraction method. The castor oil has good stability, color retention, wettability, lubricity and other effects. The almond oil is yellowish and transparent, has fragrant taste, is not only an excellent edible oil, but also an advanced lubricating oil, can resist the low temperature below 20 ℃ below zero, can be used as an important raw material of advanced paint, cosmetics and high-quality perfumed soap, and can also be used for extracting essence and vitamins. The cream, milk honey and soap are used as natural additives, and have the effects of moistening skin and resisting aging. The peanut oil is yellowish and transparent, has clear color and luster and fragrant smell, and the vitamin E in the peanut oil is a good antioxidant ingredient and has important effects on protecting skin, preventing chapping and aging and the like. Soybean oil is obtained from soybean seeds, and is the grease with the highest yield in the world. The soybean oil is various in types and can be divided into squeezed soybean oil and leached soybean oil according to the processing mode; can be divided into crude soybean oil and transgenic soybean oil according to the types of soybeans. Soybean oil is rich in vitamin E and vitamin D, and has important effects of protecting skin, preventing chapping and aging, etc. Palm oil is obtained by squeezing palm fruit from oil palm tree, and palm oil and palm kernel oil are produced from palm fruit pulp and kernel. The palm oil has moderate unsaturation degree, does not contain linolenic acid, is rich in natural vitamin E and tocotrienol, is a natural efficient antioxidant, and has lasting fragrance.
In one embodiment of the present invention, the amount of the oil is 0.1 to 10 parts by weight based on 100 parts by weight of the total composition; preferably, the grease is 2-6 parts.
In one embodiment of the invention, the microcapsule essential oil is 0-10 parts by weight relative to 100 parts by weight of the total composition; preferably, the microcapsule essential oil accounts for 1-6 parts. Preferably, the microcapsule essential oil is microcapsule slow-release essential oil, more preferably, the microcapsule essential oil is microcapsule slow-release tea tree essential oil, and the tea tree essential oil (TTO) is essential oil obtained by distilling melaleuca alternifolia leaves with steam. The melaleuca alternifolia belongs to the Myrtaceae, and about 230 varieties are known as the most powerful medical therapist of nature. The tea tree essential oil is basically monoterpene, alcohol and sesquiterpene compounds, and accounts for more than 99% of the total amount. Wherein, the main components of 4-terpene alcohol and 1, 8-cineole account for more than 50 percent, and the components are the basis of strong anti-inflammatory substances of the tea tree essential oil, so that the tea tree essential oil becomes the most powerful natural antibacterial agent, and is currently developed into various products, such as preservatives, antibacterial agents and aromatic agents. The sterilization and mite removal efficacy of the tea tree essential oil is mainly exerted in the patent. The microcapsule tea tree essential oil is slowly released, and can achieve the effects of diminishing inflammation, expelling parasites and removing odor for a long time. Meanwhile, hyaluronic acid or salt thereof in the microcapsule forms a spatial network structure through molecular chains with different lengths, and the spatial network structure is combined with carboxyl and free radicals of the molecular chains, so that the retention time of the tea tree essential oil on the skin of the pet can be effectively prolonged, and the absorption of the tea tree essential oil on the skin of the pet is promoted. Meanwhile, the high-affinity hyaluronic acid or the salt thereof and the microcapsule essential oil can act synergistically to enhance the adsorption capacity of the hyaluronic acid or the salt thereof and the microcapsule essential oil on the skin and the fur of the pet, so that the effect that the hyaluronic acid or the salt thereof and the microcapsule essential oil are retained on the fur for a long time after being washed away is achieved.
In one embodiment of the present invention, the amino acid surfactant is 0.01 to 70 parts per 100 parts by weight of the total composition; preferably, the amino acid surfactant is 4-30 parts.
In one embodiment of the present invention, the amino acid surfactant may be any of all kinds of amino acid surfactants. Preferably, the amino acid surfactant is selected from one or more of potassium cocoyl glutamate, sodium lauroyl glutamate and sodium cocoyl glycinate.
In one embodiment of the invention, the washing and caring composition further comprises a plant extract and water, wherein the plant extract accounts for 0.01-30 parts, preferably 1-15 parts, relative to 100 parts by weight of the total composition; the balance of water.
In a specific embodiment of the present invention, the plant extract is selected from one or more of lavender extract, jasmine extract, rose extract, chamomile extract, honeysuckle extract, licorice extract, tea tree extract, citronella extract, mint extract, vernonia galamensis extract. The lavender extract can clear away heat and toxic materials, clean skin, control oil content, remove freckles, whiten skin, remove wrinkles, tender skin, remove under-eye dark circles and promote regeneration and recovery of damaged tissues. The rose extract has mild property, can alleviate emotion, balance endocrine, enrich blood and qi, care skin, regulate liver and stomach, relieve fatigue, improve body constitution, and moisten and nourish skin. The flos Jasmini sambac extract has effects of relieving, diminishing inflammation and killing bacteria. The chamomile extract has the effects of repairing sensitive skin, reducing fine red blood streaks, adjusting uneven skin color and the like. The herba Menthae extract can be used for treating neuralgia, skin pruritus, erythra and eczema, and has skin repairing effect. The Vernonia esculenta extract has effects of clearing away heat and toxic materials, promoting granulation, and healing sore.
The invention discloses a preparation method of a pet washing and caring composition rich in hyaluronic acid or salt thereof, which comprises the following steps:
adding a little water into hyaluronic acid or a salt composition thereof, and uniformly stirring to obtain a first mixture;
adding an amino acid surfactant into the first mixture, and uniformly stirring to obtain a second mixture;
adding the plant extract into the second mixture, and uniformly stirring to obtain a third mixture;
adding the microcapsule essential oil into the third mixture, and uniformly stirring to obtain a fourth mixture;
adding grease into the fourth mixture, and uniformly stirring to obtain a fifth mixture;
adding water into the fifth mixture, and uniformly stirring to obtain the pet cleaning and caring composition rich in hyaluronic acid or its salt.
The pet washing and caring composition rich in hyaluronic acid or the salt thereof prepared by the preparation method has the characteristics of good soothing, moisture retention, safety and smoothness for the skin and hair of pets, and can achieve good sterilization and insect expelling effects.
The pet washing and caring composition rich in hyaluronic acid or salt thereof prepared by the preparation method of the invention utilizes the characteristics of surface activity of hyaluronic acid or salt thereof, derivatives thereof and amino acids, not only can mildly clean fur of pet cats and dogs, but also can improve skin state of pets, maintain stable physiological function of skin, enhance skin immunity and resistance, has the characteristics of moisture preservation, moistening and hair softening, is added with microcapsule essential oil with slow release effect, has good functions of killing insects, sterilizing and removing fishy smell, and can greatly prolong fragrance retention time.
The following examples of the present invention are merely illustrative of specific embodiments for carrying out the present invention and are not to be construed as limiting the invention. Other changes, modifications, substitutions, combinations, and simplifications which may be made without departing from the spirit and principles of the invention are intended to be equivalents thereof and to fall within the scope of the invention.
Examples
The experimental methods used in the following examples are all conventional methods, unless otherwise specified.
Materials, reagents and the like used in the following examples are commercially available unless otherwise specified. In order to highlight the influence of hyaluronic acid on the product, the amino acid surface activity types and contents are recorded in a fixed ratio. Examples and comparative examples all selected 10 parts of potassium cocoyl glutamate, 5 parts of sodium lauroyl glutamate, 5 parts of sodium cocoyl glycinate, for a total of 20 parts of amino acid surfactant; the plant extract comprises 10 parts of flos Matricariae Chamomillae extract and 1 part of herba Menthae extract, and the total amount is 11 parts. The preparation method of the pet cleaning and caring composition adopts the following steps:
adding a little water into hyaluronic acid or a salt composition thereof, and uniformly stirring to obtain a first mixture; adding an amino acid surfactant into the first mixture, and uniformly stirring to obtain a second mixture; adding the plant extract into the second mixture, and uniformly stirring to obtain a third mixture; adding the microcapsule essential oil into the third mixture, and uniformly stirring to obtain a fourth mixture; adding grease into the fourth mixture, and uniformly stirring to obtain a fifth mixture; adding water into the fifth mixture, and uniformly stirring to obtain the pet cleaning and caring composition rich in hyaluronic acid or its salt.
The parameters of the components in examples 1 to 10 are shown in Table 1. The parameters of each component in comparative examples 1 to 5 are shown in table 1.
TABLE 1 comparative table of components for each example
Test example 1
The evaluation of the products of the above examples and comparative examples after use of pets was evaluated according to the following method:
in the center of the pet, 140 pet dogs with hair length of about 2-4 cm, no bath for one week and fur free from obvious large stains were found, and 10 dogs were used in each group. Respectively weighing the weight of a pet, thoroughly wetting the fur of the pet with purified water, bathing the pet by using the samples of the examples and the comparative examples, wherein the usage amount of the bath foam is 5.0g/1kg of the weight, after the cleaning is finished, drying the pet dog by using a blower, and giving a blind evaluation to the pet dog by using 30 groups of dogs, wherein the blind evaluation direction comprises the cleanliness, smoothness and fragrance of the fur. And after 8h, the pet dogs are blindly evaluated for smoothness and faint scent. Performing blind test on the same item again for 24 h; the faint scent degree is measured blindly for 48h and 72 h.
The cleanliness, the moistening degree, the smoothness and the fragrance of the fur are graded according to satisfaction, acceptability, generality and dissatisfaction, and the grading intervals are 5, 4, 3, 2 and 1 respectively. Generally, the maximum deviation value is removed, the relative average value is taken, and the score is more than or equal to 4, which is more satisfactory.
The evaluation items with the score of 5 are that the fur is very clean, the surface of the fur is very moist, not dry and not frizzy, the fur is smooth and refreshing, and the smell is fresh and pleasant;
the evaluation items with the score of 4 are that the fur is clean, moist and not dry, the fur is smooth and refreshing and not rough, the smell is fresh and pleasant, and no pet odor exists;
the evaluation items with the score of 3 are that the fur is clean, not moist enough and slightly dry, the fur is smooth and smooth, and no peculiar smell exists;
the evaluation items with the score of 2 are that the fur is clean and general, the hair is slightly dry and not moist enough, the fur is not smooth and is slightly rough, and the fur has a fishy smell and peculiar smell;
the evaluation items with the score of 1 are that the fur is not clean, the fur is dry, the fur is poor in smoothness and smoothness, knotting exists and the fur has a larger pet taste;
the results are as follows:
TABLE 2 fur Effect of pets after washing and caring composition prepared in each example
Test example 2
Changes in pet skin mites: 10g of the sample of example 4 was added to 20ml of water and mixed to prepare a test group, and 10g of each of comparative example 1 and a commercially available pet shampoo having insect and mite repelling and killing effects was added to 20ml of water and mixed to prepare a control group. Respectively taking demodex on live pet cats to be divided into a 1 st group, a 2 nd group and a 3 rd group on a glass slide, recording the total number of mites in each group by 10 pet cats, respectively and uniformly dropwise adding an experimental group solution and a control group solution on the 1 st group, the 2 nd group and the 3 rd group, and observing the death condition of the mites within 60min, wherein the results are shown in the following table 3.
Table 3 shows the comparison of the results obtained with the rinse-care composition of example 4 with commercial pet shampoos
| Group of | Average number of live insects/insect | Average number of live insects/cell at 10min | Average number of live insects/cell for 30min | 1h average number of live insects/number |
| Example 4 | 31 | 20 | 6 | 0 |
| Comparative example 1 | 30 | 25 | 20 | 12 |
| Is commercially available | 30 | 25 | 23 | 13 |
The results show that the pet care composition prepared in example 4 has a significant acaricidal effect compared to comparative example 1 and the commercial pet shampoo.
Test example 3
The fungus detection method comprises the following steps: shaving the sampling part with an electric razor, sterilizing the part with 75 ° ethanol, soaking mineral oil or cleaning solution with a blade, and scraping along the hair direction and perpendicular to the skin. And uniformly smearing the scraped scurf on a glass sheet, dripping 2-3 drops of 10% KOH solution, heating for several seconds, and covering a cover glass. The fungal spores or hyphae are easy to find when the hairs with irregular edges and abnormal shapes are searched.
The product was tested on mild-skinned long-haired dogs in various veterinary clinics and fungal detection was performed according to the test methods described above. The test was maintained for 20 days and the long haired dogs were washed once a day. A total of 30 dogs were selected and divided into 6 groups of 5 dogs, and the results of using the wash and care compositions prepared in example 1, example 4, example 9, comparative example 1 and comparative example 2, respectively, and the commercial mite-killing and anti-inflammatory pet bathing products are shown in Table 4.
Table 4 comparison of fungal detection number under 40-fold microscope
As can be seen from Table 4, dogs having fungal infections of the skin before treatment were treated by deep cleaning treatment on fixed affected sites daily for 20 days after shaving. The treatment results show that the number of fungi on the skin of 5 dogs treated by the product in the example 4 after 20 days of continuous treatment is all 0, which is obviously superior to that of the pet bath products in the comparative example 1, the comparative example 2 and the market antifungal pet bath products, so that the pet shampoo containing the microcapsule essential oil in the proportion has good antifungal effect, can improve the disease resistance of the skin of dogs and cats, reduces the incidence rate of skin diseases of pets, has health care effect on the skin of dogs and cats, and improves the life quality of the dogs and cats.
While embodiments of the present invention have been described above, the present invention is not limited to the specific embodiments and applications described above, which are intended to be illustrative, instructive, and not limiting. Those skilled in the art, having the benefit of this disclosure, may effect numerous modifications thereto without departing from the scope of the invention as defined by the appended claims.
Claims (10)
1. A pet care composition enriched in hyaluronic acid or a salt thereof, comprising: hyaluronic acid or its salt composition, oil, microcapsule essential oil and amino acid surfactant.
2. The pet care composition rich in hyaluronic acid or a salt thereof according to claim 1, wherein the composition of hyaluronic acid or a salt thereof comprises hyaluronic acid or a salt thereof having a molecular weight of not more than 10KDa, hyaluronic acid or a salt thereof having a molecular weight of 100KDa to 800KDa, a crosslinked polymer of hyaluronic acid or a salt thereof, and high-affinity hyaluronic acid or a salt thereof.
3. The pet care composition enriched in hyaluronic acid or salt thereof according to claim 2, wherein the high affinity hyaluronic acid or salt thereof is obtained by complexing cationic guar and hyaluronic acid or salt thereof in polyol, the hyaluronic acid or salt thereof is one or more of hyaluronic acid or salt thereof with molecular weight of 3-2000 kDa, the cationic guar has molecular weight of 100-2000 kDa, and the mass ratio of hyaluronic acid to cationic guar is 1: (0.01-100).
4. The pet care composition rich in hyaluronic acid or a salt thereof according to any of claims 1-3, wherein the content of hyaluronic acid or a salt thereof composition is 0.01-42 parts, preferably 0.1-20 parts, more preferably 0.6-15 parts, relative to 100 parts by weight of the total composition.
5. The pet care composition rich in hyaluronic acid or a salt thereof according to any of claims 1-3, wherein hyaluronic acid or a salt thereof having a molecular weight of not more than 10kDa is 0-3%, preferably 0.05-2%, more preferably 0.1-1% in the hyaluronic acid or a salt thereof composition; hyaluronic acid or salt thereof with molecular weight of 100 KDa-800 KDa accounts for 0-5%, preferably 1.0-2.0%; 0 to 10.0%, preferably 0.01 to 5.0% of hyaluronic acid or a salt cross-linked polymer thereof; and 77-100%, preferably 92-99% of high-affinity hyaluronic acid or a salt thereof.
6. The pet care composition rich in hyaluronic acid or a salt thereof according to claim 1, wherein said oil is selected from one or more of mineral oil, vegetable oil, animal oil; preferably one or more of natural source oils and fats such as olive oil, shea butter, coconut oil, castor oil, almond oil, peanut oil, soybean oil, palm oil, avocado oil, etc.
7. The pet wash composition enriched in hyaluronic acid or salt thereof according to claim 6, wherein said oil is olive oil PEG-7 esters.
8. The pet care composition rich in hyaluronic acid or a salt thereof according to claim 6, wherein said oil or fat is 0.1 to 10 parts, preferably 2 to 6 parts, per 100 parts by weight of the total composition.
9. The pet care composition rich in hyaluronic acid or a salt thereof according to claim 1, wherein said microcapsule essential oil is 0 to 10 parts, preferably 1 to 6 parts, with respect to 100 parts by weight of the total composition.
10. The pet care composition enriched in hyaluronic acid or salt thereof according to claim 9, wherein said microencapsulated essential oil is microencapsulated slow-release tea tree essential oil.
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