WO2016088996A1 - Composition utilisant des extraits naturels pour le traitement et la prévention de maladies parodontales - Google Patents

Composition utilisant des extraits naturels pour le traitement et la prévention de maladies parodontales Download PDF

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WO2016088996A1
WO2016088996A1 PCT/KR2015/010428 KR2015010428W WO2016088996A1 WO 2016088996 A1 WO2016088996 A1 WO 2016088996A1 KR 2015010428 W KR2015010428 W KR 2015010428W WO 2016088996 A1 WO2016088996 A1 WO 2016088996A1
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extract
composition
vitamin
periodontal disease
treating
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PCT/KR2015/010428
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English (en)
Korean (ko)
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우진오
정동균
이대정
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주식회사 제이앤케이 글로벌리소스
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras

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  • the present invention relates to a composition for the treatment and prevention of periodontal disease using a natural extract, and more specifically, because the composition for the treatment and prevention of periodontal disease using a natural extract can be used in combination with dental treatment in the treatment of periodontal disease. It relates to a composition for the treatment and prevention of periodontal disease using a natural extract that can be helpful and can be taken long-term without resorting to antibiotics.
  • Republic of Korea Patent Publication No. 10-0431170 is a composition for the treatment of periodontal disease containing plant extracts, cinnamon, missing, Hojang-geun, gojija, bokbunja, eoseongcho, browning, dansam extract selected from the group of 1 or 2 It provides a composition for treating periodontal disease containing more than one species as an active ingredient, excellent plant growth inhibitory activity of periodontal disease-causing bacteria, plant extracts excellent in inhibiting activity of proteolytic enzymes secreted by periodontal disease-causing bacteria
  • the present invention discloses a composition for treating periodontal disease, which is excellent in treating periodontal disease.
  • Republic of Korea Patent Publication No. 10-1358507 relates to a composition for anti-inflammatory, antibacterial and deodorant in the oral cavity containing red ginseng and natural plant-derived extracts, oral with anti-inflammatory, antibacterial and deodorant effects derived from red ginseng and natural plants It discloses a composition for anti-inflammatory, antibacterial and deodorant and a method for preparing the same.
  • Korean Laid-open Patent Publication No. 10-2012-0117387 relates to oral compositions for preventing and alleviating gum disease, which is beneficial to gum and dental health such as kelp, shiitake mushroom, green tea extract, tocopherol, and propolis. It discloses a composition for oral cavity having the gum and dental health and oral cleansing effect using the ingredients as a raw material.
  • Natural extracts namely, the treatment and prevention of periodontal disease using plant extracts have been developed a lot, but the composition for the prevention and treatment related to chronic periodontal disease or peri-implantitis has not been developed yet, and treatment and prevention effect of periodontal disease At the same time, it helps to form bones and includes functional elements that enhance immunity, thus maximizing the effect of periodontal disease treatment, and treating and preventing periodontal disease effective treatment for chronic periodontal disease and peri-implantitis. It wasn't.
  • the purpose of one embodiment of the present invention is to use the natural extracts to prepare a composition for the treatment and prevention of periodontal disease because it can be used in conjunction with dental treatment periodontal periodontal It is to provide a composition for treating and preventing periodontal disease using a natural extract that can be useful for the treatment of the disease, and can be taken for a long time without resorting to antibiotics. More specifically, calcium, avocado extract, corn extract and vitamin C and bone soluble propolis extract, corn extract, cinnamon and vitamin C, which help bone formation, and thistle extract to help boost immunity.
  • composition for the treatment and prevention of periodontal disease is prepared to include all of vitamin B1, vitamin B2 and vitamin B6. It is an object of the present invention to provide a composition for the treatment and prevention of periodontal disease using natural extracts effective for the prevention and treatment of patients.
  • one embodiment of the present invention is calcium, avocado extract, water soluble propolis extract, corn extract, cinnamon extract, thistle extract, vitamin C, vitamin B1, vitamin B2 And it provides a composition for the treatment and prevention of periodontal disease using a natural extract, characterized in that it comprises a vitamin B6.
  • Composition for treating and preventing periodontal disease using the natural extract is calcium 35 to 60% by weight, avocado extract 0.5 to 7% by weight, water soluble propolis extract 5 to 25% by weight, corn extract 2 to 15% by weight, cinnamon extract 0.5 to 7 wt%, thistle extract 2-15 wt%, vitamin C 1-10 wt%, vitamin B1 0.01-0.3 wt%, vitamin B2 0.01-0.3 wt% and vitamin B6 0.01-0.3 wt% You can do
  • composition for the treatment and prevention of periodontal disease using the natural extract may be characterized in that the addition of any one or more from the group consisting of additives consisting of silicon dioxide, magnesium stearate, crystalline cellulose and a color coating agent in the form of a tablet form. have.
  • composition for treating and preventing periodontal disease using natural extracts is a composition for treating and preventing periodontal disease that can be ingested in parallel with dental treatment, and can be ingested at the same time as treatment with dental treatment. It can help prevent periodontal disease and treat periodontal disease.
  • periodontal disease which is composed of natural extracts, not antibiotics or chemical raw materials, it can minimize the side effects that can occur in the human body due to the abuse of antibiotics, and can be taken for a long period of time periodontal disease As well as preventing and can increase the treatment effect of periodontal disease.
  • Composition for treating and preventing periodontal disease using a natural extract according to an embodiment of the present invention including all three components that are excellent in bone formation function, immune function enhancement function, periodontal inflammation prevention and treatment functions required for dental care Because of this, the effect of preventing and treating periodontal disease is excellent.
  • compositions for treating and preventing periodontal disease only with ingredients such as water-soluble propolis extract, corn extract, cinnamon extract and vitamin C, which help to strengthen the alveolar bone and periodontal ligament around teeth, Since the ingredient for promoting bone formation and the ingredient for enhancing immunity were added together to prepare a composition for the treatment and prevention of periodontal disease, the effect of preventing and treating periodontal disease than the existing composition for treating and preventing periodontal disease Has the advantage of being superior.
  • 1 is a questionnaire of the questionnaire conducted for the adjuvant composition for treatment and prevention of periodontal disease according to an embodiment of the present invention.
  • 2 and 3 is a periodontal disease that occurs when two or more weeks of taking the drug W recipe (Recipe W) prepared with the adjuvant composition for treatment and prevention of periodontal disease according to an embodiment of the present invention among the results of the treatment evaluation test It is a graph showing the decrease rate of the 11 bacterial bacteria causing disease.
  • 6 and 7 are graphs showing the reduction rate of treponema denticola (Td) and parvimonas micra (Pm) of the results of the treatment evaluation test.
  • composition for treating and preventing periodontal disease using a natural extract according to an embodiment of the present invention (hereinafter, also referred to as 'composition for treating and preventing periodontal disease'), calcium, avocado extract, water-soluble propolis extract, corn extract, cinnamon It may be characterized by including the extract, thistle extract, vitamin C, vitamin B1, vitamin B2 and vitamin B6.
  • Three functions that are essential for the prevention and treatment of periodontal disease during dental care are bone formation, prevention and treatment of periodontal inflammation, and immunity enhancement.
  • Ingredients such as calcium, avocado extract, corn extract, and vitamin C have a strong bone-forming effect because they help to maintain and secure implant prostheses, helping to prevent and treat inflammation around the implant.
  • ingredients such as water soluble propolis extract, corn extract, cinnamon extract and vitamin C are effective in preventing or treating periodontitis because they strengthen the alveolar bone and periodontal ligament around teeth.
  • ingredients such as thistle extract, vitamin B1, vitamin B2 and vitamin B6, help to boost the body's overall immunity, and in particular, the components that help the liver function, which directly helps skin inflammation, especially vitamin B
  • the group is excellent in boosting immunity because it helps nutritional and metabolic disorders and helps prevent and treat periodontal disease.
  • the composition for treating and preventing periodontal disease using a natural extract according to an embodiment of the present invention is calcium, avocado extract, water-soluble propolis extract, corn extract, cinnamon extract, thistle extract, vitamin C, vitamin B1, vitamin B2 and Since it contains vitamin B6, it helps to form bones, prevents and treats periodontal inflammation, and because immunity is strengthened, it is necessary ingredients.
  • the composition for treating and preventing periodontal disease there is an advantage that the prevention and treatment effect of periodontal disease is superior to the existing periodontal disease treatment and prevention composition.
  • Composition for treating and preventing periodontal disease using a natural extract calcium 35 to 60% by weight, avocado extract 0.5 to 7% by weight, water soluble propolis extract 5 to 25% by weight, corn extract 2 to 15% by weight, cinnamon extract 0.5-7%, thistle extract 2-15%, vitamin C 1-10%, vitamin B1 0.01-0.3%, vitamin B2 0.01-0.3% and vitamin B6 0.01-0.3% It may be characterized by comprising a%.
  • Calcium is a component of the skeleton and teeth, 99% of the calcium content in the body is present here, and is also involved in maintaining the normal function of muscles and nerves. In addition, it regulates the contraction and relaxation of skeletal muscle and myocardial cells, and is a nutrient essential for the action of many enzymes associated with blood coagulation. Bone is composed of osteoblasts and osteoclasts (Osteoclast) cells, osteoblasts secrete collagen to form a support structure of bone, osteoblasts mature into osteocytes (Osteocytes) and cause calcification of bones. Therefore, the more calcium intake is maintained in the blood calcium concentration, calcium can be used for bone formation.
  • Ostoclast osteoblasts and osteoclasts
  • osteoclasts are stimulated by parathyroid hormones and are greatly activated when a diet is low in calcium, and the activated osteoclasts release calcium from the bone and enter the blood. Lowering calcium levels in the blood promotes the activation of osteoclasts. Since bone is formed and degraded by bone turnover (Bone remodeling) of osteoblasts and osteoclasts, calcium intake is important for bone formation and maintenance.
  • calcium is preferably contained in 35 to 60% by weight relative to the total weight of the composition for treating and preventing periodontal disease using a natural extract.
  • This is a content set according to the functional labeling functional dietary standard, according to the functional labeling functional food is known that the calcium content is 220 to 660mg per day.
  • the composition when the composition contains less than 35% by weight of calcium relative to the total weight of the composition for treating and preventing periodontal disease, the total weight of the composition for treating and preventing periodontal disease and the weight of components other than calcium Considered together, the calcium content contained in the composition for treating and preventing periodontal disease is lower than the lowest daily intake content according to the functional food functional labeling standards, there is a fear that the effect of calcium is not properly expressed.
  • Excessive calcium intake causes Nephrolithiasis, Milk-alkali syndrome, which is caused by the ingestion of milk and absorbent alkaline gels for a long time, with or without hypercalcemia and alkalosis. It may cause adverse effects such as moderate alkalosis, abnormal serum phosphatase levels, severe renal failure with hypertension and calcification, and problems with calcium-mineral interactions.
  • the calcium is preferably contained in 35 to 60% by weight relative to the total weight of the composition for the treatment and prevention of periodontal disease using natural extracts.
  • calcium may be used to prepare a composition for treating and preventing periodontal disease using a natural extract according to an embodiment of the present invention using calcium phosphate, but other types of calcium may be used.
  • avocado Persea americana Mill
  • avocado contains 18.7 g of fat, 720 mg of potassium, 0.21 mg of vitamin B2, 61.90 mg of vitamin C, 71.80 mg of vitamin B6, 1.34 mg of vitamin E, and 5.30 mg of dietary fiber.
  • Antioxidant activity, Acetyl CoA carboxylase inhibition, and antimicrobial activity have been reported as avocados.
  • the total polyphenol and flavonoid contents in methanol extracts of avocado pulp, seeds and husks were measured.
  • the total polyphenol contents were 13.89 ⁇ g / mg for avocado pulp extract, 137.2 ⁇ g / mg for seed extract and 223.45 for shell extract. It was measured to be ⁇ g / mg, it was found that the polyphenol content in the seeds and shells is 10 to 20 times more than the pulp of avocado, having a high antioxidant capacity.
  • avocado extract has an excellent polyphenol content and excellent antioxidant activity, and as the concentration of avocado increases the activity of glycoprotein (ALP) of the cell membrane increases osteoblasts.
  • the avocado extract is effective in reducing the activity of TRAP enzyme (a cytochemical marker enzyme that can measure the degree of bone destruction in rats) without cytotoxicity and inhibits the differentiation of osteoclasts.
  • TRAP enzyme a cytochemical marker enzyme that can measure the degree of bone destruction in rats
  • TRAP enzyme a cytochemical marker enzyme that can measure the degree of bone destruction in rats
  • ALP glycoprotein of the cell membrane While increasing (ALP) activity has been reported to be cytotoxic to osteoclasts, it has been demonstrated that avocado extracts have the effect of proliferating osteoblasts and inhibiting osteoclasts.
  • avocado extract has the effect of helping the synthesis of collagen (Collagen) and proteoglycan (Proteoglycan). Therefore, it plays a very important role in strengthening bones by secreting collagen, proliferating osteoblasts forming bone support structures
  • avocado extract has osteoblast proliferation effect and osteoclast suppression effect, which helps bone formation. When used as a composition for treating and preventing periodontal disease, it has excellent effect on recovery and function after bone transplantation, implant and periodontal surgery. There is.
  • the avocado extract is preferably contained in an amount of 0.5 to 7% by weight based on the total weight of the composition for treating and preventing periodontal disease using a natural extract.
  • the composition containing the avocado extract when the composition containing the avocado extract is less than 0.5% by weight relative to the total weight of the composition for treating and preventing periodontal disease, the total weight of the composition for treating and preventing periodontal disease and components other than avocado extract Considering the weight together, the content of avocado extract contained in the composition for the treatment and prevention of periodontal disease is too small, so the osteoblast proliferation and osteoclast inhibitory effects of the avocado extract are not properly expressed, so there is no possibility of adding meaning. have.
  • the avocado extract contained in the therapeutic and prophylactic composition is so excessive that the amount of vitamin E contained in the avocado extract exceeds the daily intake limit, thus preventing the absorption of vitamin K in the body. It may reduce platelet aggregation, cause bleeding after surgery, and may cause adverse symptoms such as gastrointestinal disorders, muscle weakness, headaches and chronic fatigue.
  • the avocado extract is preferably contained in an amount of 0.5 to 7% by weight based on the total weight of the composition for the treatment and prevention of periodontal disease using natural extracts.
  • the avocado extract may be prepared by a conventional method known in the art to which the present invention belongs, preferably washing and drying the avocado and pulverized and then using an extract extracted with an organic solvent such as methanol or ethanol have.
  • an organic solvent such as methanol or ethanol have.
  • the avocado was washed, dried and pulverized, and then avocado extract (Avocado Fruit 10: 1 Extract (Persea Gratissima)) extracted and extracted by adding ethanol was used.
  • Propolis is collected from the sap of trees, the bark of lost trees, and the surgery of flowers by bees, and is used for self-defense of honey bees or repair of honeycombs, mainly resins, beeswax, essential oils, pollen, various organic and mineral substances. It is composed of, and has been reported to be effective in antibacterial, antifungal, antiviral, antitumor, human immune reinforcement, wound healing as well as antioxidant activity. Various organic and mineral substances in propolis contain a large amount of more than 20 different flavonoids, and these flavonoids have been reported to exhibit strong antibacterial effects. Flavonoids of propolis are all aglycone different from flavonoids of other plants, and this compound is involved in the antibacterial action of propolis.
  • propolis since propolis does not have an antibacterial action against enterobacteriaceae, it is a very safe natural antimicrobial substance because it does not adversely affect enteric strains useful for the human body, that is, bifidobacteria or lactic acid bacteria even when administered orally.
  • Propolis has been reported to have excellent antioxidant and antibacterial effects in the oral cavity.
  • Water-soluble flavonoid mixtures are effective in treating mucosal inflammation, and are effective in treating mucosal inflammation, such as clinically inhibiting gingival bleeding in patients with periodontal disease, and reduce caries morbidity due to the antibacterial and antioxidant effects of flavonoids.
  • Flavonoids are excellent in reducing caries activity by reducing acid production in human oral saliva. For this reason, propolis has been actively developed as a component of oral health-related foods or products such as mouthwashes, periodontal disease treatments or supplements, toothpastes and the like.
  • Periodontal disease patients are suffering from inflammation occurring around various implants, especially after implantation, resulting in many problems. Patients take antibiotics to treat inflammation. Long-term use of antibiotics can cause resistance. Therefore, propolis is in the spotlight as an anti-inflammatory agent using a natural extract that can be taken in the long term because it does not develop resistance.
  • Propolis extract which is used as a dietary supplement, is made from bees by mixing their secretions with resins obtained from plants, and removing wax, extracted with water or alcohol, or extracted with carbon dioxide. will be. Total flavonoids must be present in at least 1% and para-coumaric and cinnamic acid should be identified. In addition, diethylin glycol should not be detected.
  • the composition for treating and preventing periodontal disease of the present invention is water-soluble to prevent allergic reactions and inflammation or ulceration of mucous membranes. Propolis extract was used.
  • the water-soluble propolis extract is preferably contained in 5 to 25% by weight relative to the total weight of the composition for treating and preventing periodontal disease using a natural extract. This is the amount of water-soluble propolis extract is set in consideration of the intake in the human application test confirmed the functionality.
  • the total flavonoid 16 to 17 mg is most preferred as the daily intake. Since the propolis extract used as a dietary supplement should contain at least 1% of total flavonoids, the water-soluble propolis extract is preferably 160 to 200 mg in daily intake.
  • the composition containing the water-soluble propolis extract less than 5% by weight based on the total weight of the composition for treating and preventing periodontal disease
  • the total weight and water-soluble propolis extract for treating and preventing periodontal disease Considering the weight of other ingredients together, the water-soluble propolis extract contained in the composition for treating and preventing periodontal disease is less than the minimum daily intake set in consideration of the intake in the functional application test. Therefore, there is a fear that the antioxidant action and the antibacterial action effect of the water-soluble propolis extract are not properly expressed.
  • the total weight of the composition for treating and preventing periodontal disease and the weight of components other than the water-soluble propolis extract may be considered together.
  • the amount of water-soluble propolis extract contained in the composition for treating and preventing periodontal disease is too excessive than the highest daily intake of the functional food functional labeling standard, it is not common, but it is a rare side effect of propolis. It may cause an allergic reaction and inflammation or ulceration of the mucous membrane.
  • the water-soluble propolis extract is preferably contained in 5 to 25% by weight based on the total weight of the composition for the treatment and prevention of periodontal disease using natural extracts.
  • the water-soluble propolis extract may be prepared by a conventional method known in the art to which the present invention belongs, preferably by applying heat to the raw raw raw propolis to remove the bewax (beewax), then extracted into the spirit Extracted extracts may be used.
  • a water-soluble propolis extract (Water Soluble Bee Propolis Ext. 70%) prepared by applying heat to a raw propolis raw material to remove non-wax, and then adding alcohol, was used.
  • Corn extract (corn unchecked quantitative extract, Zea Mays L.) is currently used as a component of health functional foods and products aimed at preventing periodontal disease or preventing periodontal disease. This is due to the fact that Zea Mays L. (hereinafter referred to as 'ZML'), an unchecked quantitative extract from corn, was found to be effective in improving purulent and periodontitis in 1958. It has been shown in the experiment that when taken, it has the effect of preventing and regenerating alveolar bone absorption and destruction of periodontal ligament. In addition, as a result of the reduction of dental rhythm and alveolar bone resorption in patients with periodontitis, ZML was reported to stop inflammatory degradation of bone in about 80% after topical treatment. It has been found to be effective in alleviating periodontal disease.
  • Corn extract is composed mainly of phytosterol consisting of beta-Sitosterol, Stigmasterol and Ergosterol, Squlaene, a hydrocarbon, Carotene and Tocopherol (liposoluble vitamins). Tocopherol).
  • the composition for the treatment and prevention of periodontal disease according to an embodiment of the present invention uses that containing 10% or more of beta-sitosterol.
  • Beta-sitosterol is the most widely distributed plant sterol, a precursor of vitamin D, or provitamin D, which promotes absorption of calcium, promotes alveolar bone formation, regenerates periodontal ligament fibers, Excellent function of normalization and anti-inflammatory action. Beta-sitosterol promotes osteoblast production by activating the endoplasmic reticulum of osteoblasts, promotes the regeneration of the collapsed alveolar bone, and prevents the absorption of the alveolar bone, thereby strengthening the gums. In addition, it is excellent in regenerating damaged periodontal ligament fibers and preventing abnormal shaking of teeth.
  • the composition for treating and preventing periodontal disease according to an embodiment of the present invention is beta-sitosterol. It is important to use corn extracts containing more than 10%.
  • the corn extract is preferably contained by containing 2 to 15% by weight relative to the total weight of the composition for the treatment and prevention of periodontal disease using natural extracts.
  • This is a periodontal disease is determined based on the content of the corn extract listed in the general medicine, the daily intake is preferably 80 to 120mg.
  • the total weight of the composition for treating and preventing periodontal disease and components other than corn extract Considering the weight together, the amount of corn extract contained in the composition for treating and preventing periodontal disease is too small, activating osteoblast vesicles of corn extract, and promoting calcium absorption as a precursor of vitamin D, alveolar bone Effects such as promoting regeneration and periodontal ligament fiber regeneration are not properly expressed, there is a fear that it does not add meaning.
  • the corn extract exceeds 15% by weight based on the total weight of the composition for the treatment and prevention of periodontal disease, considering the total weight of the composition for the treatment and prevention of periodontal disease and the weight of components other than corn extract, periodontal disease
  • the amount of corn extract contained in the therapeutic and prophylactic composition is so excessive that the production cost may increase, resulting in a decrease in productivity, which may affect the component content of other periodontal disease treatment and prophylactic compositions. not.
  • the corn extract is preferably contained by containing 2 to 15% by weight relative to the total weight of the composition for the treatment and prevention of periodontal disease using natural extracts.
  • the corn extract may be prepared by a conventional method known in the art to which the present invention belongs, preferably washing the corn and cornbeard together, dried and pulverized, ethanol or water is added to the pulverized ground After the extraction can be used to extract the extract can be used, corn unchecked quantitative extract commonly used in the manufacture of periodontal disease medicines.
  • the corn extract (GMO Free Corn Silk with 10% Beta Sitosterol (Zea Mays)) was prepared by washing corn, drying and pulverizing, and adding ethanol to the pulverized powder. .
  • Cinnamon is a dry, evergreen tropical cinnamon tree belonging to the family Lauraceae. Herbal medicine has been used for the treatment of headache, fever, nervousness, and pain.
  • the main ingredients of cinnamon are essential oils called cinnamon oils, which are Cinnamic aldehyde, Campen cineol, Linalool, Eugenol, Sugar, Fat, Phosphorus, Iron, Because it contains ingredients such as vitamin A, vitamin B1, and vitamin B2, it is widely used as a fragrance component in beverages, chewing gums, toothpaste and cosmetics, and bad breath remover. have.
  • it stimulates the gastrointestinal mucosa, stimulates secretion, suppresses spasms of pain in the stomach, promotes the movement of the gastrointestinal tract, and releases gas and improves absorption.
  • cinnamon stimulates nerves, promotes blood circulation, warms the body, and has an antiseptic effect of inhibiting abnormal fermentation in the intestine.
  • Cinnamic aldehydes of cinnamon have a function of persistent peripheral vasodilation (hypertension) and platelet aggregation inhibition, and effects such as sweating and clay. It is widely used for colds, analgesic, and dysmenorrhea, and cinnamon extract is also excellent in antimicrobial activity to suppress food corruption.
  • Cinnamon extract can be used as a natural antibiotic and bad breath remover because of its unique flavor, antioxidant and anti-inflammatory properties.
  • it since it is excellent in inhibiting inflammation by acting as a natural antibiotic with water-soluble propolis which is a component of the composition for treating and preventing periodontal disease of the present invention, it is an important component in the composition for treating and preventing periodontal disease.
  • the cinnamon extract is preferably contained in 0.5 to 7% by weight relative to the total weight of the composition for treating and preventing periodontal disease using a natural extract.
  • the cinnamon extract when the cinnamon extract is contained in an amount of less than 0.5% by weight based on the total weight of the composition for treating and preventing periodontal disease, the total weight of the composition for treating and preventing periodontal disease and components other than cinnamon extract Considering the weight together, the content of cinnamon extract in the composition for the treatment and prevention of periodontal disease is too small, and the antioxidant and anti-inflammatory effects of cinnamon extract may not be properly expressed, which may prevent it from functioning as a natural antibiotic. .
  • cinnamon extract when included in excess of 7% by weight based on the total weight of the composition for the treatment and prevention of periodontal disease, considering the total weight of the composition for the treatment and prevention of periodontal disease and the weight of components other than cinnamon extract, periodontal disease
  • the amount of cinnamon extract contained in the therapeutic and prophylactic composition is so excessive that it can be fatal to a person with a fever or a lot of heat in the body, there is a fear that productivity may decrease due to increased production cost, and treatment and prevention of other periodontal disease It is not preferable because it may affect the component content of the composition.
  • the cinnamon extract is preferably contained in an amount of 0.5 to 7% by weight based on the total weight of the composition for the treatment and prevention of periodontal disease using natural extracts.
  • the cinnamon extract may be prepared by a conventional method known in the art to which the present invention belongs, preferably extract the water by grinding the cinnamon, it can be used through the process of filtration, concentration and purification have.
  • after adding water to the cinnamon is repeated three times the extraction process to extract for 2 hours at a temperature of 75 to 85 °C, after the filtration process, concentrated under reduced pressure and purified at a temperature of 75 to 85 °C
  • the cinnamon extract (Cinnamon Bark 2: 1 Extract (Cinnamomum Zeylanicum)) prepared by drying was purchased and used.
  • Milk Thistle is an asteraceae, scientific name is Silybum marianum (L.) Gaertn, tinnitus is Carduus silybum, and fruit and seeds are used for food.
  • herbalists have used thistle (milk thistle) seeds to protect the liver, such as chronic epilepsy, and in Europe, major countries such as Silymarin of thistle (milk thistle) protect liver cells from free radicals. Because it is known to be used as a liver supplement or a dietary supplement.
  • Thistle (milk thistle) extract is produced by pulverizing thistle milk (milk thistle), extracted by alcohol, filtration, concentration and purification, 320 ⁇ 660mg of functional ingredient silymarin (Silymarin) It is a raw material containing about / g.
  • Silymarin consists of four isomers: Silybin (A, B), Silychristin, Silydianin, and Isosilybin (A, B).
  • Thistle contains a component called Silymarin (Silymarin) is known to be effective in improving the function of the liver. Since the antioxidant activity is 10 times higher than vitamin E, glutathione secretion is increased to facilitate liver detoxification, which is effective in regenerating liver tissue, which helps restore liver function. In addition, silymarin (Silymarin), which is extracted from the seeds of thistle, has the effect of inhibiting the proliferation of cancer cells, and the research results are also effective in preventing and treating inflammation or liver damage, which is a side effect of cancer patients undergoing chemotherapy. Turned out to be excellent.
  • the milk thistle silymarin (Silymarin) component is used as a liver supplement and a dietary supplement because it has an excellent antioxidant activity, such as protecting the liver cells from free radicals, and is beneficial for liver health.
  • the recovery of liver function is very important in the treatment of periodontal disease because of the direct relationship between skin and immunity. Therefore, the milk thistle silymarin (Silymarin) component is effective in restoring liver function, it is an essential ingredient for recovery and function after bone graft, implant and periodontal surgery, so the composition for the treatment and prevention of periodontal disease Essential ingredient in the.
  • the thistle extract is preferably contained in an amount of 5 to 15% by weight relative to the total weight of the composition for treating and preventing periodontal disease using natural extracts. This is the content set according to the functional labeling standards of functional foods.
  • thistle seeds and berries are used as food ingredients, and thistle extract is also used as a general medicine.
  • Thistle extract is used abroad as a dietary supplement and medicine. It is listed as a food in the Prehensine Database and as a Dietary Supplement in the USP-NP.
  • the WHO monograph recommends 200-400 mg daily intake of silymarin, but functional health foods are considered in consideration of safety as a dietary supplement.
  • the daily intake is preferably 80 to 240 mg based on silymarin.
  • the composition of the composition for treating and preventing periodontal disease when the composition of the composition for treating and preventing periodontal disease is less than 5% by weight based on the total weight of the composition for treating and preventing periodontal disease, the total weight of the composition for treating and preventing periodontal disease and components other than thistle extract Considering the weight together, the amount of thistle extract contained in the composition for treating and preventing periodontal disease is too small, compared to the minimum daily intake set in consideration of the content set according to the functional food functional labeling standard. There is a fear that the function recovery effect is not properly expressed, so there is no meaning to add.
  • thistle extract contains more than 15% by weight relative to the total weight of the composition for the treatment and prevention of periodontal disease, when considering the total weight of the composition for the treatment and prevention of periodontal disease and the weight of components other than thistle extract, health function
  • the amount of thistle extract contained in the composition for the treatment and prevention of periodontal disease is too much higher than the maximum daily intake set in consideration of the content set according to the food functional labeling criteria, and thus, harmful symptoms such as diarrhea, headache and joint pain may occur. There is concern.
  • the thistle extract is preferably contained by containing 5 to 15% by weight relative to the total weight of the composition for the treatment and prevention of periodontal disease using natural extracts.
  • the thistle extract may be prepared by a conventional method known in the art to which the present invention belongs, preferably, thistle is pulverized and extracted with alcohol, and then the extract prepared through the process of filtration, concentration and purification to use Can be. In the present invention, thistle was pulverized and extracted by the addition of alcohol, and then the extracted extract was filtered and concentrated and stagnant thistle extract (Milk Thistle 80% Silymarin (Silybum marianum)) purchased and used.
  • Vitamin C is a six-carbon lactone, and plants and most animals can synthesize vitamin C in the body, but humans, primates, guinea pigs, large bats, and some species of birds and fish can synthesize it. Therefore, it must be in the form of food. Vitamin C contains both reduced ascorbic acid and oxidized dehydroascorbic acid, which can be converted. In fact, there are two types of food we eat.
  • Vitamin C has the function of forming connective tissue, which is used as a coenzyme of various enzymatic reactions in vivo, and is involved in the synthesis of collagen, a major protein constituting connective tissue such as skin, skeleton, blood vessels and cartilage.
  • connective tissue a major protein constituting connective tissue such as skin, skeleton, blood vessels and cartilage.
  • the amino acids proline and lysine are hydrated to form hydroxyproline and hydroxylysine
  • vitamin C plays a role in reducing the iron content of the hydroxylase. To maintain collagen tissue.
  • the electron donating function of vitamin C induces antioxidant activity to remove free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS).
  • free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS).
  • ROS reactive oxygen species
  • RNS reactive nitrogen species
  • tissues susceptible to damage from free radicals such as eyeballs, neutrophils, and semen, are known to have a relatively high content of vitamin C.
  • LDL low density lipoprotein
  • the radicals of vitamin C have a relatively long half-life of 5 to 10 seconds compared to other antioxidants, and thus are recognized as stable antioxidants.
  • Vitamin C is also known to be excellent in iron absorption effects, such as promoting the absorption of vegetable iron that is not bound to hemoglobin by converting iron to a reduced form in the small intestine.
  • vitamin C is necessary for the formation and maintenance of connective tissue, and it is effective for iron absorption and protects cells from harmful oxygen. Therefore, vitamin C is recovered and improved after bone transplantation, implant and periodontal surgery.
  • vitamin C is preferably contained in an amount of 1 to 10% by weight based on the total weight of the composition for treating and preventing periodontal disease using a natural extract. This is a content set according to the recommended daily intake of adult men and women.
  • the average requirement for vitamin C in men and women is 75 mg / day and the recommended intake is 100 mg / day.
  • the recommended intake is set based on the amount of urine excretion while keeping leukocytes' vitamin C levels to a maximum.
  • composition of the composition for treating and preventing periodontal disease is less than 1% by weight of the total weight of the composition, when considering the total weight of the composition for treating and preventing periodontal disease and the weight of components other than vitamin C, The content of vitamin C contained in the composition for the treatment and prevention of periodontal disease is less than the average required amount of, there is no meaning to add vitamin C, there is a fear that the effect of vitamin C is not properly expressed.
  • vitamin C when vitamin C is included in an amount of more than 10% by weight based on the total weight of the composition for treating and preventing periodontal disease, when considering the total weight of the composition for treating and preventing periodontal disease and the weight of the components other than vitamin C, the amount of vitamin C contained in the composition for the treatment and prevention of periodontal disease is too excessive than the recommended intake of, may cause problems due to the excessive supply of vitamin C.
  • vitamin C When supplemental foods in which excess vitamin C is added, it is known to mainly cause gastrointestinal symptoms such as nausea, vomiting, bloating, abdominal pain and diarrhea. In addition, fishery excretion and nephrolithiasis, increased uric acid excretion, excessive iron absorption, and vitamin B12 levels have been reported. In pregnant women, excessive vitamin C ingestion has been reported to cause vitamin C dependence in newborns. In animal and in vitro studies, vitamin C is pro-Oxidant and may have adverse effects. It is reported that it is possible.
  • the vitamin C is preferably contained in an amount of 1 to 10% by weight based on the total weight of the composition for treating and preventing periodontal disease using a natural extract.
  • Vitamin B1 is a hexagonal ring (Pyrimidine) containing nitrogen in the center and sulfur pentagonal ring (Thiazole) connected by a methylene bridge.
  • Pork, sunflower seeds, brewer's yeast, soybeans, potato wheat germ, whole grains and fortified grains, peas, asparagus, meat guts, peanuts and other seeds, mushrooms and watermelons are good sources of vitamin B1.
  • vitamin B1 there are many foods containing vitamin B1, but in general, the content is low, so it is desirable to eat a variety of foods.
  • Thiamin pyrophosphate (TPP), a coenzyme form of vitamin B1 has two phosphate groups, including pyruvate, alpha-ketoglutarate, and branched-chain keto acids. It serves to catalyze the decarboxylation of the same alpha-keto acids. It also catalyzes the transketolation reaction between hexose phosphates and pentose phosphates. Transketolase, which is required for ketotransition reactions, is an enzyme that requires TPP to produce pentose sugar from glucose, which is hexose, in the Pentose phosphate pathway. Vitamin B1 is therefore required for the metabolism of carbohydrates and branched amino acids (leucine, isoleucine, valine). That is, vitamin B1 is involved in energy metabolism, so the required amount of vitamin B1 is highly correlated with energy consumption.
  • vitamin B1 is required for carbohydrate and energy metabolism, when used as a composition for the treatment and prevention of periodontal disease, it can solve the weakness of carbohydrate metabolism that should be chewed and digested by periodontal disease patients. It performs an effective function in periodontal regeneration of patients with chronic periodontal disease.
  • vitamin B1 is preferably contained in an amount of 0.01 to 0.3% by weight relative to the total weight of the composition for treating and preventing periodontal disease using a natural extract. This is a content set according to the recommended daily intake of adult men and women.
  • the average vitamin B1 requirement of Korean adults is 1.0mg / day for males and 0.9mg / day for females.
  • the recommended intake is 120% of the average intake, 1.2mg / day for males and 1.1mg / day for females.
  • the indicator used in setting the recommended intake is the red blood cell's transketolase activity. The activity of this enzyme is measured by comparing the activity with and without the addition of the coenzyme of vitamin B1 after the destruction of blood cells.
  • vitamin B1 When vitamin B1 is contained in an amount of less than 0.01% by weight based on the total weight of the composition for treating and preventing periodontal disease, when considering the total weight of the composition for treating and preventing periodontal disease and the weight of components other than vitamin B1, The content of vitamin B1 contained in the composition for the treatment and prevention of periodontal disease is less than the average required amount of, it does not mean adding vitamin B1, there is a fear that the effect of vitamin B1 is not properly expressed.
  • vitamin B1 naturally, but there have been reports of toxicity when high concentrations of vitamin B1 are consumed for therapeutic purposes.
  • High levels of vitamin B1 usually cause central nervous system-related symptoms such as headaches, nausea, anxiety, insomnia, tachycardia, and lack of energy.
  • the vitamin B1 is preferably contained in an amount of 0.01 to 0.3% by weight based on the total weight of the composition for the treatment and prevention of periodontal disease using a natural extract.
  • Vitamin B2 (Riboflavin) is a three-hexagonal ring molecule, usually present in the form of Flavin adenine dinucleotide (FAD) and Flavin mononucleotide (FMN) in the biological world, with very few free vitamin B2. Vitamin B2 is relatively stable against acid, heat and oxidation, but weak against alkali and light. Animal foods such as liver, meat, chicken and fish and dairy products are good sources of vitamin B2, and soybeans, green vegetables, grains and eggs are also used as sources of vitamin B2.
  • FAD Flavin adenine dinucleotide
  • FMN Flavin mononucleotide
  • Vitamin B2 has excellent caloric metabolism. Coenzymes of vitamin B2 are involved in various enzymatic reactions, especially in caloric metabolism. Various types of vitamin B2 enzymes are used for the metabolism of carbohydrates, fats and amino acids, dehydrogenation, hydroxylation, oxidative decarboxylation, dioxygenation and oxygen peroxide. It is essential for the reduction reaction.
  • vitamin B2 Deficiency of vitamin B2 causes deficiency such as stomatitis, stomatitis, and periarthritis in the oral cavity, oral or rash of the nose and mouth, seborrheic dermatitis of the vulva, ocular hyperemia, photophobia, premature cataract, and anemia. . Therefore, vitamin B2 deficiency causes various symptoms for the oral cavity, and proper intake of vitamin B2 is effective for periodontal disease and chronic periodontal disease because vitamin B2 has an excellent function in energy generation and metabolism.
  • the composition for the treatment and prevention of periodontal disease of the present invention there is a concern that the metabolism may not be smooth due to the high content of plant extracts, that is, fat-soluble components, the treatment and prevention of periodontal disease because the metabolism can be smoothed by the addition of vitamin B2 It is an essential ingredient to enhance the effect of the composition.
  • vitamin B2 is preferably contained in an amount of 0.01 to 0.3% by weight relative to the total weight of the composition for treating and preventing periodontal disease using a natural extract. This is a content set according to the recommended daily intake of adult men and women.
  • the average amount of vitamin B2 can be set based on the activity of glutathione reductase in red blood cells and the amount of vitamin B2 excretion in urine.
  • the average amount of vitamin B2 in Korean adults is 1.3 mg / day for men and 1.0 mg / day for women.
  • the recommended intake is 120% of the average intake for men 1.5mg / day and women 1.2mg / day.
  • the composition of the composition for treating and preventing periodontal disease is less than 0.01% by weight of vitamin B2
  • the total weight of the composition for treating and preventing periodontal disease and the weight of components other than vitamin B2 are considered. Since vitamin B2 content in the composition for the treatment and prevention of periodontal disease is less than the average required amount of vitamin B2, it may not effectively affect calorie metabolism (the metabolic pathways of carbohydrates, fats and amino acids). There is no meaning or the effect of vitamin B2 may not be properly expressed.
  • the vitamin B2 is preferably contained in an amount of 0.01 to 0.3% by weight relative to the total weight of the composition for treating and preventing periodontal disease using a natural extract.
  • Vitamin B6 is present in foods in pyridoxine (Pyridoxine, PN), pyridoxal (PL), pyridoxamine (Pyridoaxamine, PM) or in their respective phosphorylated forms (PLP, PNP, PMP).
  • PLP, PMP, and protein are present in a combined form.
  • PN, PNP, and sugar are present in a combined form.
  • Coenzyme forms of vitamin B6 are PLP and PMP, in particular PLP is a form of biological activity is very high.
  • the free form of vitamin B6 varies with acidity, but is relatively unstable and easily denatured.
  • Sources of vitamin B6 include animal foods such as fish, pork, chicken, eggs and animal intestines (liver and kidneys), as well as brown rice, soybeans, and oats. Dairy products are relatively low in vitamin B6.
  • Vitamin B6 is a necessary ingredient for the use of proteins and amino acids.
  • PLP is a coenzyme of enzymes involved in the metabolism of about 100 kinds of amino acids such as aminotransferase, decarboxylase and stereoisase.
  • PLP is required for the reaction to synthesize non-essential amino acids, and if there is no PLP, all amino acids become essential amino acids and must be supplied by meal.
  • PLP is a stereoisomer and acts on the interconversion of D-type and L-type amino acids. Since only L-type amino acids are used when protein is synthesized in the human body, the action of PLP is important.
  • vitamin B6 also acts as a coenzyme of the catabolism of the homocysteine and Phosphorylase (Phosphorylase) reaction, it is also an essential component in maintaining the homocysteine level of blood normal.
  • Phosphorylase Phosphorylase
  • vitamin B6 is a necessary ingredient for the prevention and treatment of oral diseases such as stomatitis, stomatitis, and sulfitis.
  • the liver function is restored by working with thistle (milk thistle) extract of the composition for the treatment and prevention of periodontal disease of the present invention
  • the vitamin complex of vitamin B1, vitamin B2 and vitamin B6 is milk thistle (thistle extract) )
  • the metabolism facilitates to enhance immunity and to treat and prevent periodontal disease is excellent.
  • vitamin B6 is preferably contained in an amount of 0.01 to 0.3% by weight relative to the total weight of the composition for treating and preventing periodontal disease using a natural extract. This is set according to the recommended daily intake of adult men and women.
  • the average amount of vitamin B6 in Korean adults is 1.3mg / day for men and 1.2mg / day for women, and the recommended intake is 120mg of average intake, 1.5mg / day for men and 1.4mg / day for women.
  • composition of the composition for the treatment and prevention of periodontal disease contains less than 0.01% by weight of vitamin B6, when considering the total weight of the composition for treating and preventing periodontal disease and the weight of components other than vitamin B6,
  • the content of vitamin B6 contained in the composition for the treatment and prevention of periodontal disease is less than the average required amount of, it does not mean adding vitamin B6, there is a fear that the effect of vitamin B6 is not properly expressed.
  • Vitamin B6 excess from food has not been reported, but it has been reported that sensory neuropathy and skin lesions may occur when a large amount of the drug is taken for the purpose of treating diseases such as premenstrual syndrome. Ingestion of high doses of vitamin B6 can cause nerve damage, tingling limbs, staggering steps, loss of sensation around the mouth, and loss of muscle coordination.
  • the vitamin B6 is preferably contained in an amount of 0.01 to 0.3% by weight based on the total weight of the composition for the treatment and prevention of periodontal disease using a natural extract.
  • the composition for treating and preventing periodontal disease using a natural extract calcium 35 to 60% by weight, avocado extract 0.5 to 7% by weight, water soluble propolis extract 5 to 25% by weight, corn extract 2 to 15% by weight, cinnamon extract 0.5 to 7% by weight, thistle extract 2 to 15% by weight, vitamin C 1 to 10% by weight, vitamin B1 0.01 to 0.3% by weight, vitamin B2 0.01 to 0.3% by weight and vitamin B6 0.01 to Most preferably, it comprises 0.3% by weight.
  • the composition for the treatment and prevention of periodontal disease using the natural extract by adding any one or more from the additive group consisting of silicon dioxide, magnesium stearate, crystalline cellulose and a color coating agent in the form of a tablet It may be characterized in that it is manufactured as.
  • compositions for the treatment and prevention of periodontal disease using the natural extract in the form of tablets for easy ingestion added silicon dioxide, magnesium stearate, crystalline cellulose and color coating agent
  • Components of the additive group consisting of does not cause interaction with each component of the composition for treating and preventing periodontal disease using the natural extract, it is preferable that the composition is composed of components that do not affect the effective aspect.
  • 0.1 to 1 parts by weight of silicon dioxide, 0.1 to 1.5 parts by weight of magnesium stearate, crystals, corresponding to an additive group based on 100 parts by weight of the composition for treating and preventing periodontal disease using the natural extract 12 to 26 parts by weight of cellulose and 1 to 5 parts by weight of the color coating agent may be added to form a tablet formulation.
  • the content of the components of the additive group consisting of silicon dioxide, magnesium stearate, crystalline cellulose and a color coating agent is suitable for preparing a periodontal disease treatment and prevention composition using a natural extract in a tablet form, and treatment of periodontal disease using a natural extract. And it can be set to an optimized content so as not to affect the effect of the composition for prevention.
  • the ratio of 0.1 to 1 parts by weight of silicon dioxide, 0.1 to 1.5 parts by weight of magnesium stearate, 12 to 26 parts by weight of crystalline cellulose and 1 to 5 parts by weight of the color coating agent based on 100 parts by weight of the composition for treating and preventing periodontal disease using a natural extract. It is preferred to prepare further in the form of tablet form by further addition.
  • composition for the treatment and prevention of periodontal disease using a natural extract according to an embodiment of the present invention.
  • the periodontal disease adjuvant composition using the natural extract prepared as in Example was prepared in a tablet form of the drug recipe W. (Recipe W) to be administered to the study subjects, and expressed in the recipe W. (Recipe W) in the questionnaire and the questionnaire results. It is.
  • 1 is a questionnaire of a survey conducted to grasp the effects and use status of purchase patients with the composition for the treatment and prevention of periodontal disease according to an embodiment of the present invention.
  • the questionnaire items in this study were classified by patient symptom, non-answered phone call, effectiveness of recipe W after 1 month of receiving dose, status of effect compared to other products, classification by period, periodontal condition improvement, periodontal
  • the questionnaire consists of 9 questions such as improvement by symptom, repurchase status for one month, and intention of continuous taking. About 10 selected dentists at Seoul National University, Hallym University, and Pusan National University evaluated the selected items and evaluated the suitability of the selected items.
  • the number of males and females of recipe W is 251 females and 105 males.
  • the ages are 2 in 20s, 4 in 30s, 35 in 50s, 127 in 50s, 116 in 60s, and 70s. It is distributed in 65, 80 and 7 members.
  • Symptoms included 248 patients with peri-implantitis, 80 chronic periodontal diseases, 28 general periodontal diseases, 18 in the implant plan, and 6 patients with osteoporosis medication.
  • the most common symptom was improvement of tooth agitation and gum weakness (71 cases), improvement of pain and swelling of 61 cases, improvement of bleeding when brushing teeth, improvement of ache 42, and improvement of bad breath.
  • 251 of the 356 subjects responded to the telephone questionnaire.
  • 251 respondents showed peri-implantitis 70% (182), chronic periodontal disease 23% (59), periodontal disease 4% (10), and 3% (7) of the implant plan.
  • 0% (1 person) is a substitute for osteoporosis drugs, which is biased for patients with peri-implant peritonitis, but the number of patients is considered as a basis for introducing periodontal disease supplements.
  • the results of the survey can be considered as the final result, considering that the proportion of symptom by 356 subjects and that of symptom by 251 respondents are almost similar.
  • the results of Recipe W the patients who took it continuously seemed to be effective enough. Among the 173 patients who took more than a month, 22% (99) of the actual repurchase patients were repurchased. 56.9% (143 patients) of the patients desired showed the importance of taking the patient.
  • the quantitative value (concentration) of the causative agent of periodontal disease-causing bacteria before and after ingestion of the composition for treating and preventing periodontal disease was analyzed.
  • the periodontal disease adjuvant composition using the natural extract prepared as in Example was prepared as a drug recipe W. (Recipe W) in the tablet form to be taken by the subjects.
  • the treatment efficacy evaluation was commissioned by Hallym University and was given a clinical approval number, such as “IRB Approval Number 14-1-58, Hallym University Institutional Review Board.”
  • a total of 30 subjects consisted of adults aged 25 to 75 years. The average age of the subjects was 44.73 years. Patients diagnosed with mild chronic simple periodontitis were selected. Patients who had not received treatment for periodontal disease within the last 6 months and who voluntarily agreed and signed the subject's consent It was made.
  • the sample was collected and sealed in a preservative solution and container of the cytoperio analysis system (cytogen co. Ltd). Co. Ltd,) was sent to a laboratory for genetic testing, extracted DNA from the sample and attached a DNA probe (fluorescent marker) and analyzed the type and quantitative value (concentration) of the causative agent causing periodontal disease by real-time PCR.
  • cytoperio analysis system cytogen co. Ltd. Co. Ltd,
  • the causative agents of investigation were aggregatibacter actinomycetemcomitans (Aa), porphyromonas gingivalis (Pg), tannerella forsythia (Tf), treponema denticola (Td), prevotella intermedia (Pi), fusobacterrium nucleatum (Fn), parvimonas micra (Pm), campylob camp A total of 11 bacteria were identified, including eikenella corrodens (Ec), streptococcus mutans (Sm), and streptococcus sorbinus (Ss).
  • the reduction of bacteria was confirmed by quantitative analysis of each bacterium before and after taking the drug and after 3 weeks of taking the drug. A total of 30 subjects were included in a single group. Thirty subjects measured the reduction of periodontal disease-causing bacteria after two weeks of administration, and thirteen subjects measured the reduction of periodontal disease-causing bacteria after three weeks of administration. . Since the test results did not follow the normal distribution in all strains as an objective evaluation method before and after treatment, the statistical significance was evaluated by the Wilcoxon signed rank test, a nonparametric size comparison method, and evaluated under the conditions shown in Table 1 below. Was determined at P ⁇ 0.05.
  • Table 2 shows the 11 bacterial levels causing periodontal disease, aggregatibacter actinomycetemcomitans (Aa) was not detected in all subjects.
  • the levels of the remaining 10 bacteria except for Aa were all decreased, and the levels of 11 bacteria, which cause periodontal disease, were higher when taking drugs for 3 weeks or more than when taking drugs for 2 weeks or more. The decrease was found to be greater.
  • the decrease rate of the 11 bacterial bacteria causing the periodontal disease caused by taking the drug for two weeks or more is shown in the graphs of FIGS. 2 and 3, and the cause of the periodontal disease caused by taking the drug for three weeks or more 11
  • the rate of reduction of bacterial levels of the species is shown in the graphs of FIGS. 4 and 5.
  • Table 2 Considering the results of quantitative value (concentration) of periodontal disease-causing bacteria shown in Table 2 above, the number of bacteria was increased and decreased or the number of bacteria was not changed, and the statistical significance of the normality and P value of the treatment efficacy evaluation test.
  • Table 3 summarizes the statistical significance according to the normality and P value of the treatment efficacy evaluation test before and after 2 weeks of taking the drug
  • Table 4 shows the treatment corresponding to before and after 3 weeks of taking the drug. It is the result that summarized the statistical significance by the normality and P-value of the efficacy evaluation test.
  • the quantitative value (concentration) of the causative agent of periodontal disease-causing bacteria before and after ingestion of the composition for treating and preventing periodontal disease According to the analysis results, no aggregatibacter actinomycetemcomitans (Aa) was detected in all the subjects, and among the 10 causes of periodontal disease, more than half of the patients showed a decrease in the number of bacteria. Td), prevotella intermedia (Pi), fusobacterrium nucleatum (Fn), parvimonas micra (Pm), and campylobacter rectus (Cr).
  • Pg is anaerobic bacilli, closely related to acute or chronic periodontitis, and high frequency in periodontal sac of adult periodontitis patients. It was investigated. Td is a helix bacteria and is detected in most parts of periodontal pockets and is known to be associated with acute progressive periodontitis and necrosis or ulcerative periodontitis. Pi is a black pigment producing bacterium that causes hormone-related periodontitis and promotes complex infections. Fn is an anaerobic Gram-negative bacterium and is known to be detected with high frequency with helix bacteria in almost all areas where acute necrotic ulcerative gingivitis occurs.
  • Pm is an anaerobic Gram-positive cocci and has been reported to be associated with recurrent or refractory periodontal disease and implant failure.
  • Cr is an anaerobic Gram-negative bacillus and is known to cause periodontal pocket formation and secondary bacterial infections.
  • the amount of microbial reduction after taking Td and Pm also showed statistical significance.
  • the present invention can be used in combination with dental treatment because it was prepared using a natural extract for the treatment and prevention of periodontal disease can be useful in the treatment of periodontal disease, and can be taken in the long term without depending on antibiotics Since it is a composition for treating and preventing periodontal disease using a natural extract, it can be usefully used for long-term periodontal disease treatment and prophylaxis.

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Abstract

La présente invention concerne une composition utilisant des extraits naturels pour le traitement et la prévention de maladies parodontales et, plus spécifiquement, une composition utilisant un extrait naturel pour le traitement et la prévention de maladies parodontales caractérisée par le fait qu'elle contient du calcium, un extrait d'avocat, un extrait de propolis soluble dans l'eau, un extrait de maïs, un extrait de cannelle, un extrait de chardon-marie, de la vitamine C, de la vitamine B1, de la vitamine B2, et de la vitamine B6. La composition pour le traitement et la prévention de maladies parodontales est préparée à l'aide de ces extraits naturels, et peut donc être utilisée conjointement avec un traitement dentaire, de sorte que la composition peut être utile dans le traitement de maladies parodontales, et les patients peuvent prendre ladite composition pendant une longue période, même sans dépendre d'antibiotiques. En outre, la composition contient tous ces ingrédients, qui sont excellents en termes de trois fonctions nécessaires pour le traitement dentaire, à savoir une fonction de formation osseuse, une fonction de renforcement immunitaire, et une fonction de traitement et de prévention de la parodontite, et, par conséquent, la composition présente d'excellents effets de prévention et de traitement de maladies parodontales.
PCT/KR2015/010428 2014-12-03 2015-10-02 Composition utilisant des extraits naturels pour le traitement et la prévention de maladies parodontales WO2016088996A1 (fr)

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KR101665093B1 (ko) * 2015-06-15 2016-10-12 서재원 치아-치조골용 조성물 및 이를 포함하는 기능성 식품
KR102141623B1 (ko) * 2018-12-20 2020-08-05 동의대학교 산학협력단 계피 추출물을 유효성분으로 포함하는 염증성 통증 예방 또는 치료용 조성물
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KR20230159770A (ko) 2022-05-13 2023-11-22 서울프로폴리스 주식회사 면역기능을 강화하는 원산지가 다른 혼합 원료로 이중 기능성 수용성 프로폴리스 추출물 및 그 제조방법

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