Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
  • B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
  • B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
  • B65B5/101—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
  • B65B5/103—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
  • B65B35/00—Supplying, feeding, arranging or orientating articles to be packaged
  • B65B35/10—Feeding, e.g. conveying, single articles
  • B65B35/16—Feeding, e.g. conveying, single articles by grippers
  • B65B35/18—Feeding, e.g. conveying, single articles by grippers by suction-operated grippers
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
  • B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
  • B65B37/04—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged by vibratory feeders
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
  • B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
  • B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
  • B65B5/105—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by grippers
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
  • B65B57/00—Automatic control, checking, warning, or safety devices
  • B65B57/10—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged
  • B65B57/14—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged and operating to control, or stop, the feed of articles or material to be packaged
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
  • B65B57/00—Automatic control, checking, warning, or safety devices
  • B65B57/18—Automatic control, checking, warning, or safety devices causing operation of audible or visible alarm signals
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
  • B65B65/00—Details peculiar to packaging machines and not otherwise provided for; Arrangements of such details
  • B65B65/02—Driving gear

Definitions

• the present invention relates generally to the field of automated oral solid pharmaceutical packaging mechanisms for packaging oral solid pharmaceuticals in packages in accordance with patient prescription information. More specifically, the present invention is directed to systems and methods for automatically verifying placement of oral solid pharmaceuticals within packaging according to patient prescription data.
• a variety of systems and methods are disclosed which provide rapid and efficient verification of oral solid pharmaceutical product placement within packaging in accordance with patient prescription data.
• the systems and methods which are described below provide multiple independent verifications within a single piece of automation that ensure absolute confidence that the placement of oral solid pharmaceuticals within packaging strictly matches patient prescription dosing information.
• robotic pick-and-place automation is used to transfer oral solid pharmaceuticals from moveable trays or canisters that have been quality checked by a pharmacist to package locations in accordance with patient prescription data.
• a variety of sensors are used in order to verify that the oral solid pharmaceuticals have been properly placed in the desired oral solid pharmaceutical package locations precisely according to the patient prescription data.
• a pharmacist places oral solid pharmaceutical products within dispensing trays or canisters which are used to present the oral solid pharmaceutical products for picking and placing via the robotic pick-and-place machinery.
• a further sensor or imaging unit associated with the pick- and-place device verifies that the oral solid pharmaceutical product presented by the tray or canister matches the size and shape and/or color of an expected oral solid pharmaceutical product that is to be placed within the packaging material in accordance with patient prescription data that is stored by a computer associated with the system.
• the robotic pick-and-place continues to transfer one oral solid pharmaceutical product to a desired package location which has a dosing time corresponding to the patient prescription data that is for the package that is currently being filled.
• additional sensing units ensure that the transfer is completed into the desired package location in order to verify that the robotic pick-and-place unit has dropped the oral solid pharmaceutical product into a desired package location.
• the imaging sensor of the robotic pick-and-place device determines that the oral solid pharmaceutical product presented at the tray or canister is not a match to the expected oral solid pharmaceutical product according to the current patient prescription data, then the system issues an alert to the system operator in order to prevent the erroneous transfer of oral solid pharmaceutical products into the packaging material and will not pick that oral solid pharmaceutical.
• a med verification tray or transfer sensing unit is located between the end of arm tooling for the robotic pick-and-place mechanism and a oral solid pharmaceutical product package or temporary store having cavity locations corresponding to the cavities of a solid pharmaceutical package that is to be filled by the system.
• the med verification tray or transfer sensing unit preferably includes a plurality of sensors that operate to confirm transfer from the robotic pick- and-place end of arm tooling and the package cavity location corresponding to the prescription data that is currently being filled by the system. It is preferred that the system is able to ensure that a specific cavity location is being filled by confirming the drop of the oral solid pharmaceutical from the robotic pick-and-place end of arm tooling.
• an optical sensor unit includes an emitter that emits a wide beam that at least substantially covers a region above the cavity location that is to be filled.
• One or more receiving units are located opposite the emitting unit and sense the emitted beam generated by the emitter.
• An interrupt signal is generated when the one or more receiving units sense that at least a portion of the beam has been interrupted.
• the emitter and receiving unit are preferably individually associated with each package cavity location, it is possible to confirm that an oral solid pharmaceutical that has been transferred by the robotic pick-and-place unit from the dispensing tray or canister specifically into a desired oral solid pharmaceutical package cavity location corresponding to the patient prescription data.
• This technique ensures strict compliance for packaging oral solid pharmaceutical products in accordance with stored patient prescription data.
• the sensors of the med verification tray or transfer sensing unit preferably sense any additional breach of the beam immediately after the drop of the oral solid pharmaceutical product in order to ensure that the oral solid pharmaceutical product does not bounce from the desired oral solid pharmaceutical packaging location when the oral solid pharmaceutical product is dropped by the robotic pick-and-place device.
• a further verification may also be performed by imaging the packaged pharmaceuticals and matching the oral solid pharmaceutical products located within each package cavity with the corresponding patient prescription data for the specific dosing time corresponding to the package cavity location.
• Conventional systems have not been able to provide this high level of confidence for the existing automated oral solid pharmaceutical packaging systems.
• the present invention overcomes these shortcomings and deficiencies of the existing systems thereby providing a much more economical and efficient packaging solution.
• Figure 1 illustrates a first exemplary embodiment of the overall robotic pick-and-place oral solid pharmaceutical packaging system of the present invention
• Figure 2 illustrates a first exemplary embodiment of the med verification tray or transfer sensing unit of the present invention
• Figure 3 illustrates a second exemplary embodiment of the med verification tray or transfer sensing unit of the present invention
• Figure 4 is a flow diagram illustration of the verification process
• Figure 5 illustrates the end of arm tooling for the robotic pick-and-place device
• Figure 6 illustrates a dispensing canister with its lid in the open position
• Figure 7 is a cut-away illustration of the dispensing canister illustrated in Figure 6;
• Figure 8 illustrates robotic transfer of a dispensing canister
• Figure 9 illustrates the robotic pick-and-place end of arm tooling with the removable suction tip secured for pill transfer.
• FIG. 1 illustrates a first preferred exemplary embodiment of the present invention which is generally shown at 10 in the illustration.
• a robotic pick-and-place unit 12 transfers oral solid pharmaceutical products from the transfer trays or cassettes 14, 15, 16 into individual oral solid pharmaceutical package locations in accordance with patient prescription data.
• the individual transfer trays or cassettes 14, 15, 16 are preferably transferred to the respective locations shown in the illustration by another transfer robot from a staging location at which a pharmacist or technician fills the individual trays or cassettes from bulk storage.
• An initial verification is provided by a pharmacist or technician in order to ensure that the medications placed into the transfer trays or cassettes 14, 15, 16 match the medication designated for a specific transfer tray or cassette.
• Bar coding verification or other automatically verified visual coding is preferably used by the automated system in order to confirm that an individual tray or cassette that is staged adjacent the robotic pick-and place unit 12 for filling matches the designation provided by the pharmacist or technician at the time of filling.
• An additional verification of the oral solid pharmaceutical is performed by an imaging unit (not shown) that is preferably associated with the end of arm tooling portion 18 of the robotic pick-and-place unit 12.
• the imaging unit provides image data for comparison with a library of image data that is used to ensure the oral solid pharmaceutical actually picked up by the robotic pick-and place unit 12 matches an expected oral solid pharmaceutical designated by a prescription to be filled based on a plurality of visual characteristics including one or more of shape, size, and/or color of the solid oral pharmaceutical.
• the imaging unit is also preferably used in order to ensure that the end of arm tooling is placed properly above a specific oral solid pharmaceutical so that the suction tip is able to grab and move an individual solid pharmaceutical.
• An automated processing unit compares the actual image data with expected image data to determine whether there is a match, if there is no match then an alert is issued to the system operator.
• the end of arm tooling initially engages a suction tip that is secured to the transfer tray or cassette from which a solid oral pharmaceutical is to be transferred for packaging.
• the suction tip is a soft rubber end that is engaged and removed from the end of arm tooling of each cassette so that each cassette or transfer tray has its own dedicated suction tip thereby avoiding the potential for cross- contamination from different medications that are filled by the system.
• the suction tip of the end of arm tooling is again secured to its corresponding transfer tray or cassette so that it is available for use the next time that a solid oral pharmaceutical is to be transferred from the transfer tray or cassette.
• the round suction tip is preferably temporarily secured at the transfer tray or cassette via a plastic semicircular structure so that the end of arm tooling can easily engage and disengage the suction tip of each cassette or transfer tray.
• Figure 1 also illustrates the location of the med transfer verification unit 20 that is placed above a package or package template that is to be filled by the system.
• the med transfer verification unit 20 incorporates a plurality of sensors that verify the transfer into a specific package or package template cavity corresponding to a patient prescription that is filled by the system.
• FIG. 2 illustrates a first exemplary embodiment of the med transfer verification unit 20.
• the med transfer verification unit 20 preferably includes an array of cavities 22 that each individually provide a transfer path for a solid oral pharmaceutical that is packaged by the system of the present invention.
• the array of cavities 22 of the med transfer verification unit 20 preferably correspond with the individual cavities of an oral solid pharmaceutical product package that is located beneath the med transfer verification unit 20.
• Each cavity of the package or package template corresponds with a specific patient dosing time and the system automatically transfers each required oral solid pharmaceutical into its specified location strictly in accordance with predetermined patient prescription data using the robotic pick-and- place unit.
• Figure 2 also illustrates a plurality of electromagnetic emitter units 26 that are used to verify that medication transferred by the robotic pick-and-place unit actually drops into a desired package cavity or template location.
• an electromagnetic energy receiving unit (not shown) is placed opposite each of the electromagnetic emitting units and a path is formed in the med transfer verification unit 20 through the oral solid pharmaceutical transfer path for each cavity in a given row or column of the med transfer verification unit 20 in order to confirm that an oral solid pharmaceutical has been deposited in a desired cavity according to the predetermined patient prescription data.
• the med transfer verification unit 20 it is possible to verify that an oral solid pharmaceutical has been deposited by the end of arm tooling but verification is only possible for rows or columns of the med transfer verification unit 20.
• additional emitters and receivers can be used in order to provide greater resolution for pill drop verification into each individual cavity.
• the med transfer verification unit 20 also acts as a barrier between cavities to prevent inadvertent transfer of the medication between the cavities.
• Figure 3 illustrates an alternate embodiment of the med transfer verification unit 20 wherein each cavity 22 of the med transfer verification unit 20 includes its own pair of electromagnet emitter and receiver units for specifically confirming that a solid oral pharmaceutical has been dropped into a specific cavity of a package in accordance with patient prescription data.
• the electromagnetic emitter units are not shown in the illustration of Figure 3.
• Figure 3 illustrates the med transfer verification unit 20 and the individual electromagnetic receiving units 30 that are individually associated with each cavity of the med transfer verification unit 20.
• This sensing of the drop at each individual cavity provides confirmation that the oral solid pharmaceutical that has been dropped by the robotic pick-and-place unit into the package strictly in accordance with the predetermined patient prescription data.
• the individual electromagnetic emitters and receivers can also be used to ensure that pills have not bounced out from the cavities by verifying that only a single break in the beam is associated with each pill drop.
• Additional image data from optical sensing units positioned above and/or below the package cavity may be used to further confirm that each individual cavity has been properly filled with the oral solid pharmaceuticals strictly in accordance with the predetermined patient prescription data.
• Figure 4 is a flow diagram which illustrates the overall process for automatically verifying the placement of oral solid pharmaceutical products into specific cavities of a package strictly in accordance with patient prescription data stored in an electronic memory of a computer controller that is used for controlling the packaging machinery.
• a pharmacist or technician verifies transfer of medication from bulk storage into the appropriate canister or dispenser for the specified medication.
• the medication canister is returned to a carousel where it can be automatically retrieved by a robot for transfer to the robotic pick-and place device of the present invention.
• a bar code, QR code or rfid reader associated with the system reads a code on the canister before it is positioned at a specific location in a staging area so a robotic retriever can transfer the desired canister automatically to the robotic pick-and-place unit.
• a bar code or other automated reader reads a code or data from the canister when it is transferred to the staging area of the robotic pick-and-place packaging system in order to ensure that the system transfers the desired medication.
• image data from the pick-and-place unit verifies that the individual pill being transferred has physical characteristics matching those of the expected pill.
• the system verifies drop of the pill into the specific package cavity corresponding to the patient prescription data.
• the resultant package is labeled and sealed with the patient specific data after all required medications for all doses specified by patient prescription data have been filled by the system into the cavities of the product package.
• the med transfer verification tray includes one or more lights that illuminate at a region of the tray corresponding to a specific cavity of the package that is to be filled with an oral solid pharmaceutical. This assists in the manual transfer of oral solid pharmaceuticals into specific package cavities according to patient prescription data. The remaining operations associated with pill transfer can then be performed in accordance with manual transfer into a package cavity.
• the system cause one or more lights in a specific region to illuminate in order to guide the user to place a solid pharmaceutical in a desired package location corresponding to patient prescription data.
• FIG. 5 illustrates the details of the end of arm tooling for the robotic pick-and-place device which is shown generally at 60.
• High pressure and low pressure lines 62 and 64 operate to generate a vacuum at the suction tube 65.
• a pressure sensor 66 located proximate the suction tube 65 operates to ensure that a pill has been picked up by the system based on a predetermined pressure change at the pressure sensor 66.
• a valve 67 is a pneumatic solenoid switch that selectively applies the vacuum at the suction tube 65.
• the switch is preferably a 2 msec switch which causes the pressure change within 10 msec at the suction tube end within
• the solenoid switch or valve 67 consists of four standard ports and the port A and B are the supply of negative pressure and positive pressure. Port A is directly coupled to the vacuum ejector which supplies the negative pressure and port B is directly coupled to a positive pressure regulator which supplies low positive pressure. As a result, the P port is the port which supplies the vacuum pressure and the positive pressure to the suction tube. Ports A and B always have the vacuum and positive pressure active during picking and placing operations. This arrangement assures rapid pressure changes at the end of the suction tube 65. The positive pressure is required to simply and effectively remove the vacuum pressure at the end of suction tube 65.
• emitters such as model LV S 62 manufactured by Keyence as an optical emitter along with an optical sensor.
• a Fairchild semiconductor infrared emitting diode can be used as the light source in conjunction with an optical sensor.
• emitters and sensor can be used to sense a break in the sensed emission beam associated with the transit of an oral solid pharmaceutical into a product package cavity.
• one or more imaging units could be used to sense the transit of oral solid pharmaceuticals into package cavities but this arrangement requires additional image data processing in order to identify transfer into a specific package cavity.
• Figure 6 illustrates placement of a dispensing canister or cassette at the staging area of the robotic pick-and-place system generally at 70.
• the cassette 72 includes a rotating lid portion 74 and the removable rubber tip 75 for the end of the suction tube of the robotic pick- and place device.
• the removable rubber or neoprene tip 75 is secured into a plastic locking member based on the resilient nature of the rubber or neoprene tip 75 and the shape of the locking member which is preferably semi-cylindrical in order to match the contour of the removable rubber or neoprene tip 75.
• each dispensing canister or cassette 72 After the dispensing canister or cassette 72 is secured into the staging area of the robotic pick-and-place system, the suction tube of the robotic pick- and-place system is inserted into the removable rubber or neoprene tip 75.
• Each dispensing canister or cassette preferably includes its own removable rubber or neoprene tip to ensure that there is no cross-contamination of medicines via the system. Each medication therefore has its own removable rubber or neoprene tip and cross-contamination is eliminated.
• the dispensing canister or cassette 72 includes a vision region 76 at which medications are picked up by the robotic pick-and-place unit.
• the rotating lid portion 74 includes a barrier portion 77 that separates medications from a storage region during transit of the dispensing canister or cassette 72.
• a locking base portion 78 mechanically secures the dispensing canister or cassette 72 based on interaction with a protruding portion of the dispensing canister or cassette 72.
• Those skilled in the art will appreciate that a variety of known mechanical and electro-mechanical locking mechanisms may be used to secure the dispensing canister or cassette 72 to the staging area.
• Each location of the staging area includes a linear motor 79 for adjusting a resting angle of the dispensing canister or cassette 72 when secured to the staging area.
• the linear motor 79 selectively causes vibration of the dispensing canister or cassette 72 in order to shake solid oral pharmaceuticals from a storage region of the dispensing canister or cassette 72 to the vision region 76 so that the robotic pick-and-place unit can conveniently grab solid oral pharmaceuticals from the vision region for placement in packaging as described above.
• a digital imaging unit that is preferably secured to the end of arm tooling for the robotic pick-and- place unit guides the suction tube and the removable rubber or neoprene tip 75 in order to properly secure a solid oral pharmaceutical located in the vision region 76 for transfer to a package.
• the preferred angle of tilt provided by the linear motor 79 for the dispensing canister or cassette 72 in order to easily transfer solid oral pharmaceuticals from a storage portion to the vision portion of the dispensing canister or cassette 72 depends on a number of factors.
• the factors considered in selecting an appropriate tilt angle include the relative fill level for the storage portion of the dispensing canister or cassette 72. Greater fill indicates less tilt and when the dispensing canister or cassette 72 is almost empty, a greater tilt must be provided. Additional factors that should be considered in making this determination include the slope of the internal ramp connecting the storage region and the vision region 76 of the dispensing canister or cassette 72 as well as the size and shape of the medications that are stored by the dispensing canister or cassette 72. Generally, a tilt of approximately 10-20 degrees is preferable for transferring the oral solid pharmaceuticals to the vision region by vibration.
• the system monitors the number of solid oral pharmaceuticals in the dispensing canister or cassette 72 so that the angle of tilt can be dynamically altered in order to provide the most desirable transfer of solid pharmaceuticals into the vision region 76 of the dispensing canister or cassette 72. This is accomplished by noting when the technician or pharmacist has filled the dispensing canister or cassette 72 and the pill count is then decremented based on the number of oral solid pharmaceuticals that have been packaged by the robotic pick-and-place unit from a particular canister.
• the amount of vibration provided by the linear motor 79 also depends on a number of factors including pill size, shape and weight.
• a database be maintained by the system so that an electronic controller may access an electronic memory having this stored information so that the controller can selectively operate the linear motor 79 at a desired tilt angle and at a desired vibration in order to conveniently transfer medications from the storage region to the vision region of the dispensing canister or cassette 72.
• the vibration amplitude is typically a few tenths of a millimeter and the duration is typically a fraction of a second to several seconds at a frequency of a few kilohertz.
• a database should be maintained which stores the most desirable transfer characteristics for the linear motor 79 including tilt, and vibration parameters.
• a mechanical cam 82 preferably engages a static arm of the staging area for the robotic pick-and-place unit so that placement of the dispensing canister or cassette 72 in the staging area causes opening of the rotating lid portion 74 and a barrier portion 77 when the dispensing canister or cassette 72 is placed in the staging area of the robotic pick-and-place unit.
• FIG. 7 is a cut-away view of an exemplary dispensing canister or cassette 72.
• Gripping structures 81 are used by the transfer robot to transfer the dispensing canister or cassette 72 to the staging area of the robotic pick-and-place unit.
• This view clearly illustrates the vision region 77 and the storage region 86 with the sloped bottom between the vision region and the storage region 86.
• the sloped arrangement of the bottom for the storage region 86 enables convenient transfer of the oral solid pharmaceuticals from the storage region 86 to the vision 77 based on tilt and vibration of the dispensing canister or cassette 72 as noted above.
• Figure 8 illustrates an alternate arrangement for the dispensing canister or cassette which is generally shown at 90.
• Figure 8 also illustrates the end of arm tooling 91 for the robotic unit that transfers the dispensing canister or cassettes from storage locations to the staging region of the robotic pick-and-place unit.
• the dispensing canister or cassette includes a sliding lid 92 which the end of arm tooling for placement the dispensing canister or cassette engages via arm 93 once the canister has been placed in the staging area in order to slide open the sliding lid 92.
• the barrier that is attached to the lid engages an end of the vision region shown at 94 in order to ensure that medications do not inadvertently fall into the vision region during transit. This ensures that the vision region maintains a single layer of solid oral pharmaceuticals which can be easily grabbed via the end of arm tooling for the robotic pick-and-place unit.
• Figure 9 illustrates the robotic pick-and-place end of arm tooling and the removable rubber or neoprene tip 75 secured to the suction tip for grabbing medications.
• the pressure sensor located at the end of arm tooling adjacent the suction tip is preferably monitored during pill transit in order to ensure that there is no inadvertent drop of the pill during transit before the pill is place in the container.

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• Engineering & Computer Science (AREA)
• Mechanical Engineering (AREA)
• Medical Preparation Storing Or Oral Administration Devices (AREA)
• Warehouses Or Storage Devices (AREA)

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• 2015
  • 2015-11-03 ES ES15857770T patent/ES2855275T3/es active Active
  • 2015-11-03 KR KR1020227034089A patent/KR102642474B1/ko active IP Right Grant
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  • 2015-11-03 JP JP2017523980A patent/JP6743000B2/ja active Active
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