WO2016070489A1 - 一种沉香原液，其制备工艺和用途 - Google Patents

一种沉香原液，其制备工艺和用途 Download PDF

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WO2016070489A1
WO2016070489A1 PCT/CN2015/000677 CN2015000677W WO2016070489A1 WO 2016070489 A1 WO2016070489 A1 WO 2016070489A1 CN 2015000677 W CN2015000677 W CN 2015000677W WO 2016070489 A1 WO2016070489 A1 WO 2016070489A1
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agarwood
water
weight
stock solution
parts
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English (en)
French (fr)
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孙广娥
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孙广娥
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • C11B9/025—Recovery by solvent extraction
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • C11B9/027—Recovery of volatiles by distillation or stripping
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/40—Tea flavour; Tea oil; Flavouring of tea or tea extract
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the invention relates to an agarwood stock solution, a preparation process and a use thereof.
  • Agarwood (a famous doctor) is a plant of the genus Aquilaria agallocha Roxb., leaves elliptic-lanceolate, lanceolate or oblanceolate, apex long apex; umbels without stalk or stalk short; flowers white, long fruit 3 cm or more. It is native to Indonesia, Cambodia and Vietnam, and is also cultivated in Taiwan. Agarwood is Aquilaria sinensis (lour.) Gilg. and Aquilaria agallocha Roxb. Wood containing resin.
  • the medicine can be divided into Domestic agarwood and imported agarwood, of which imported agarwood is mainly produced in India, Malaysia and other places: domestic agarwood, also known as Hainan agarwood, mainly produced in Hainan Island, Guangxi and other places called domestic agarwood or earth agarwood, daughter fragrance, its spicy, bitter sexually lukewarm, with the effect of qi and pain relief, warming and stopping vomiting, and qi and asthma.
  • domestic agarwood also known as Hainan agarwood, mainly produced in Hainan Island, Guangxi and other places called domestic agarwood or earth agarwood
  • daughter fragrance its spicy, bitter Sexually lukewarm, with the effect of qi and pain relief, warming and stopping vomiting, and qi and asthma.
  • Chinese herbal medicine Aquilaria Resin (Aquilaria Resin, Aloeswood, Agarwood or Eaglewood) is a traditional and valuable herbal and natural fragrance in China, Japan, India, Southeast Asia and the Middle East.
  • Aquilaria sinensis (Lour.) G English name lncenseTree, also known as fragrant wood (Hainan), white wood incense (Guangzhou, Yunnan, Shuangjiang, Simao), tooth fragrant tree, daughter fragrance (Guangdong) stack incense (Materia Medica The outline of the series), Qingguixiang, Yaxiang, and Wanxiang (Guangdong) are the only plant resources for the production of Chinese herbal medicine Aquilaria sinensis. It is a precious medicinal plant unique to China.
  • White wood incense, earth agarwood, and daughter fragrant belong to the genus Rutaceae, a subtropical evergreen tree, which is a precious medicinal plant unique to China. Baimuxiang is based on its resin-containing wood. The medicinal material is called agarwood. It is the authentic source of Chinese traditional Chinese medicine agarwood. It is also the only plant resource for producing Chinese herbal medicine agarwood. Its function is the same as the wood-containing wood of the imported Chinese medicine agarwood. Chinese herbal medicine Shenxiang is China, Traditional precious herbs and precious natural spices from Japan, India and other Southeast Asian countries.
  • Agarwood has strong antibacterial effect. Its aroma is in the spleen, clearing the spirit, replenishing the five internal organs, relieving cough and phlegm, warming the stomach and warming the spleen, ventilating and setting pain, and can be used as medicine. It is the best medicine of the best medicine. Slightly warm, bitter and bitter. In the temperature drop, warm kidneys. Qi and pain, warm and stop vomiting, gas and asthma. It is used to treat chest and abdomen swelling and pain, stomach cold and vomiting hiccups, kidney deficiency, gas and asthma. The dosage is 1.5 ⁇ 4.5g, and the decoction should be followed.
  • the soil agarwood contains volatile oil and resin, and the volatile oil contains Agarospirol, which has a calming effect.
  • Medicinal has the effect of relieving pain, regulating the liver, and warming the kidney. Indications: Qi Qi reverse wheezing, vomiting hiccups, abdominal pain, waist and knee cold, large intestines secret, urinary gas, men cold.
  • agarwood can be reduced in the reverse, it can and stomach, rise temper, warm and not dry, good and not vent. Therefore, people can take agarwood when they vomit because they eat cold food, or if they suffer from cholera because they eat unclean food.
  • Agarwood is still a healthy star for the elderly, and the elderly are prone to constipation, but long-term use of agarwood can be avoided. Young people feel dizzy and tinnitus because of their busy work. If you can't sleep at night, Agarwood can help them fall asleep.
  • Mold-infected agarwood contains Agaro-spirol, Agarol, Agarofuran, dihydro-aramid, 4-hydroxydihydrofuran, 3,4-dihydroxydihydrofurfuran , Nor-ketoaga-rofuran; agarwood containing no mold infection, sulfur, celery, linalool, etc.
  • Baimuxiang contains volatile oil, among which sesquiterpene components: scented snail alcohol, baimuxinic acid, baimuxinal, baimu-xinol, dehydrobaimuxinol, white wood furan (sinenofuranal), ainenofuranol, ⁇ -amphibious furan, dihydrocarrageenan, isobaimuxinol.
  • 6-hydroxy-2-(2- [6-hydroxy-2-(2-phenylethyl)chromone] is AH3,6-methoxy-2-(2-phenylethyl)chromone [6-methoxy-2-(2) -phenylethyl)chromone] is AH4,6,7-dimethoxy-2-(2-phenylethyl)chromone [6,7-dimethoxy-2-(2-phenylethyl) Chromone] is AH5,6-methoxy-2-[2-(3'-methoxyphenyl)ethyl]chromone ⁇ 6-methoxyl-2-[2-(3'-methoxyphenyl)ethyl]chromone ⁇ is AHbl, 2-(2-phenylethyl)chromone [2-(2-phenylethy
  • the domestic agarwood contains volatile oil, among which the sesquiterpene components are: agarospirol, agarol, gmelo-furan, a- and ⁇ -agarfuran, dihydrofuran furan ( Dihydroa-garofuran), nor-ketoagarofuran, 4-hydroxydihydroagarofuran, 3,4-dihydroxydihydroagarofuran, a- A-guaiene, a-bulnesene, kusunol, karanone, dihydrokaranone, oxoagarospirol, 1 (10), 11-guaiacene-15-aldehyde [guaia-1(10), 11-dien-15-al], 3,11- celery diene-9-one (seline-3,11 -dien-9-one), 3,11-sedipin-9-ol (seline-3, 11-dien-9-ol), chenkoheremol, and the like.
  • benzylacetone also contains aquillochin, liriodendron ). It also contains 2-(2-phenylethyl)chromone [2-(2-phenylethyl)chromone] and its dimer and trimer components: AH1, AH1a, AH2, AH2a, Ah2b, AH3, AH4, AH5 AH6, AH7, AH8, AH9, A10, AH11, AH12, AH13, AH14, AH15, AH16, AH17, AH18, AH19b, AH19b, AH20, AH23, of which AH1 is also called agaretol, AH2 is also called AH2. It is iso-agaretol (isoagarotetrol).
  • agarwood It is necessary to select a sinking piece of good quality and without coloring or sizing, especially thick slabs. Wash it with water After the net is put into the water and boiled, the first time the dried perfume is more impurities, such as the dust, the secretion of insect ants, the decaying plant body, etc., it should be dumped; the second time the boiling perfume can be directly consumed. You can use old perfume to brew old tea such as Pu'er and ⁇ tea. Agarwood can not only remove the old gas in the tea, but also make the old taste deeper and more mellow. Agarwood is very resistant to foaming, and a piece of incense can often be soaked for months.
  • An object of the present invention is to provide a stock of agarwood comprising agarwood volatile oil and water, wherein the agarwood volatile oil is from 35 to 45 parts by weight of white woody, 25 to 35 parts by weight of agarwood and 25 to 35 parts by weight of daughter fragrance. Extracted from the mixture.
  • the agarwood stock solution is obtained by extracting a mixture of 40 parts by weight of white woody, 30 parts by weight of earthy agarwood and 30 parts by weight of daughter.
  • Another object of the present invention is to provide a process for preparing an agarwood stock solution, the process comprising:
  • step 2) adding the agarwood mixture obtained in the step 1) to the purified water and immersing at room temperature for 0.5-1.5 hours;
  • the purified water is natural mineral water or purified water in an amount of 10-15 times the weight of the agarwood.
  • steps 2 and 3 are carried out in a closed container.
  • the agarwood stock solution of the present invention is used for the preparation of drinking water.
  • the drinking water further comprises a fragrance and a flavoring agent.
  • the drinking water further comprises a natural preservative.
  • the agarwood stock solution of the present invention can also be used in food processing.
  • the agarwood stock solution of the invention can also be used as a raw material in deep processing processes such as tea, spices and essential oils.
  • the agarwood stock solution of the invention contains three kinds of agarwood extracts of white woody, earthy agarwood and daughter's aroma, although the chemical constituents of the three kinds of agarwood are basically of the same type, for example, there are mainly sesquiterpene compounds, 2- (2-Phenylethyl) chromone, triterpenoids, aromatics, fatty acids, etc., but due to the difference in the content of the specific components of the three kinds of agarwood, the agarwood stock solution prepared by using the mixture of the three agarwoods It not only contains the volatile oil components of these three agarwoods, but also has the advantages of three agarwood extracts.
  • the aroma of the agarwood stock prepared by using these three kinds of agarwood is more pure than the general agarwood extract, and has a good effect on the central nervous system, especially for improving the quality of sleep.
  • the composition and content of the agarwood stock solution of the present invention were determined by GC-MS (gas chromatography-mass spectrometry) (gas chromatography conditions: the column was a Varian Cpsil 5CB (30 mx 0.25 nm x 0.25 nm) elastic quartz capillary; the injection temperature was 250 ° C.
  • the carrier gas is high-purity nitrogen, the flow rate is 1.0ml/min, no split injection; the injection volume is 1 ⁇ l, the heating procedure is: 90°C for 4min, 1°C/min to 150°C, heat for 25min, then 2 °C/min rose to 180 °C, and finally increased to 230 °C at 2 °C / min: 70min; mass spectrometry conditions: ion source is EI source, electron energy 70eV; solvent delay 4min, mass scan range 50-500m / z full range Scan), the main components and contents are as follows.
  • Figure 1 is a flow chart showing the production of the agarwood stock solution of the present invention.
  • the prepared agarwood puree is added to the seasoning after adding spices and flavoring, and can be used as a finished product of agarwood drinking water after passing the test.
  • the prepared agarwood puree is seasoned by adding spices and flavoring agents, and then added with a natural preservative to be bottled. After passing the test, it can be used as a finished product of agarwood drinking water.
  • the prepared agarwood puree is seasoned by adding spices and flavoring agents, and then added with a natural preservative to be bottled. After passing the test, it can be used as a finished product of agarwood drinking water.
  • the prepared agarwood puree is added to the seasoning after adding spices and flavoring, and can be used as a finished product of agarwood drinking water after passing the test.
  • the prepared agarwood puree is added to the seasoning after adding spices and flavoring, and can be used as a finished product of agarwood drinking water after passing the test.
  • the cooking apparatus used in the above Examples 1-5 is a circular steamer with a heating device at the bottom.
  • the upper part has a lid, and the lid has a hinge device.
  • the lid is divided into two parts, one of which has a handle, and the user can view the cooking condition in the pot during use; the other part is connected to the draft tube at the upper end. It is a steam-removed pipe, and the draft pipe is connected to the condensing pipe, and the outlet of the condensing pipe is the water intake port.
  • the agarwood stock solution obtained in the above Examples 1-5 can also be used as a deep processing process for tea, spices, essential oils, foods and the like.
  • Example 1 the stock solution prepared in Example 1 and the white wood scent, earth agarwood, and daughter scented liquid prepared according to the method of Example 1 (the same quality white wood scent, earth agarwood, and daughter scent were used instead of the three agarwood mixtures, other conditions were not Change, finally collect the same volume of agarwood stock solution).
  • the recommended oral intake for humans is three times a day, 100 mL each time (by weight 60 kg), 1.7 mL/kg ⁇ bw.
  • mice clean grade ICR mice and feed.
  • Feeding conditions temperature 20-25 ° C, relative humidity 40% -70% barrier system.

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Abstract

一种沉香原液，其包括沉香挥发油和水，其中所述沉香挥发油是从35-45重量份的白木香，25-35重量份的土沉香和25-35重量份的女儿香的混合物中提取得到的，其制备工艺包括以下步骤：1）按重量计，将用清水清洗后晾干的白木香、土沉香和女儿香按一定重量比混合得到混合物；2)将步骤1）得到的沉香混合物加入到净水中在常温下浸泡0.5-1.5个小时；3）加热煮沸步骤2）的沉香和水的混合物，含有沉香挥发油成分的水蒸气经冷凝管冷凝，形成沉香原液。

Description

一种沉香原液，其制备工艺和用途 技术领域
本发明涉及一种沉香原液，其制备工艺和用途。
背景技术
沉香(名医别录)同属植物沉香Aquilaria agallocha Roxb.，叶椭圆状披针形、披针形或倒披针形，先端长渐尖；伞形花序无总梗或梗短；花白色，蒴果长3厘米以上。原产印度尼西亚，柬埔寨及越南，台湾亦有栽培。沉香为瑞香科植物白木香Aquilaria sinensis(lour.)Gilg.及沉香Aquilaria agallocha Roxb.含有树脂的木材.因系木的心材体重，体重，置水中则沉，气香故而得名，药材可分为国产沉香和进口沉香，其中进口沉香主产于印度、马来西亚等地：国产沉香又名海南沉香，主产于海南岛、广西等地称为国产沉香或土沉香、女儿香，其味辛、苦、性微温，具行气止痛、温中止呕、纳气平喘的功效，用于胸腹胀闷疼痛、胃寒呕吐呃逆、肾虚气逆喘急，健康的白木香植物并不产生沉香，只有通过自然因素(雷劈、火烧、虫蛀、动物攀抓、人为砍伤等)的作用，沉香才会在白木香植物中逐渐形成，沉香含挥发油的量较高，具有浓郁的香气，是沉香挥发性药效的主要成份，沉香临床应用广泛具有消化系统和中枢神经系统保护等药理作用。
中药沉香(AquilariaResin、Aloeswood、Agarwood或Eaglewood)是中国、日本、印度、东南亚以及中东国家传统名贵的药材和天然香料。土沉香(Aquilaria sinensis(Lour.)G)，英文名lncenseTree，又称香材(海南)、白木香(广州、云南、双江、思茅)、牙香树、女儿香(广东)栈香(本草纲目拾遗)、青桂香、崖香、莞香(广东)是我国生产中药沉香的唯一植物资源，为我国特有的珍贵药用植物。
白木香、土沉香、女儿香同属瑞香科沉香属植物，是一种亚热带常绿乔木，为我国特有的珍贵药用植物。白木香以其含树脂的木材入药，药材名为沉香，为国产中药沉香的正品来源，也是我国生产中药沉香的唯一植物资源。其功用与进口中药沉香的含树酯的木材相同。中药沉香乃是中国、 日本、印度以及其他东南亚国家的传统名贵药材和名贵天然香料。
据《本草纲目》记载，沉香木具有强烈的抗菌效能，其香气入脾、清神理气、补五脏、止咳化痰、暖胃温脾、通气定痛、能入药，是上等药材极品。性微温，味辛、苦。降气温中，暖肾纳气。行气止痛，温中止呕，纳气平喘。用于治疗胸腹胀闷疼痛、胃寒呕吐呃逆、肾虚气逆喘急等病症。用量1.5～4.5g，入煎剂宜后下。土沉香含挥发油及树脂，挥发油中含沉香螺醇(Agarospirol)，具有镇静作用。药用具有行气止痛、调中平肝、温肾纳气之功效。主治：治气逆喘息，呕吐呃逆，脘腹胀痛，腰膝虚冷，大肠虚秘，小便气淋，男子精冷。除此之外，沉香可以降逆调中，它能和胃气，升脾气，性温而不燥，善行而不泄。所以当人们因为暴吃生冷的食物而呕吐不止，或因吃进不干净的食物而患上霍乱都可以服用沉香。除此之外，沉香还是老年人的健康福星，老年人容易便秘，但长期服用沉香可以得以避免。年轻人因为工作繁忙而感到头晕耳鸣，彻夜难眠的话，沉香也可以帮助他们香甜入睡。
沉香的丙酮提取物经皂化蒸馏，得挥发油13％，其中含苄基丙酮、对甲氧基苄基丙酮等，残渣中有氢化桂皮酸、对甲氧基氢化桂皮酸等。经霉菌感染的沉香含沉香螺醇(Agaro-spirol)、沉香醇(Agarol)、沉香呋喃(Agarofuran)、二氢沉香呋喃、4-羟基二氢沉香呋喃、3，4-二羟基二氢沉香呋喃、去甲沉香呋喃酮(Nor-ketoaga-rofuran)；未经霉菌感染的沉香含硫、芹子烷(Selinane)、沉香醇等。
白木香含挥发油，其中倍半萜成分：沉香螺醇，白木香酸(baimuxinic acid)，白木香醛(baimuxinal)，白木香醇(baimu-xinol)，去氢白木香醇(dehydrobaimuxinol)，白木香呋喃醛(sinenofuranal)，白木香呋喃醇(ainenofuranol)，β-沉香呋喃，二氢卡拉酮，异白木香醇(isobaimuxinol)。还含其他挥发成分：苄基丙酮，对甲氧基苄基丙酮，茴香酸(anisic acid)，又含2-(2-苯乙基)色酮类成分：6-羟基-2-(2-苯乙基)色酮[6-hydroxy-2-(2-phenylethyl)chromone]即是AH3，6-甲氧基-2-(2-苯乙基)色酮[6-methoxy-2-(2-phenylethyl)chromone]即是AH4，6，7-二甲氧基-2-(2-苯乙基)色酮[6，7-dimethoxy-2-(2-phenylethyl) chromone]即是AH5，6-甲氧基-2-[2-(3′-甲氧基苯)乙基]色酮{6-methoxyl-2-[2-(3’-methoxyphenyl)ethyl]chromone}即是AHbl，2-(2-苯乙基)色酮[2-(2-phenylethyl)chromone]即是AH8，6-羟基-2-[2-(4′-甲氧基苯)乙基]色酮{6-hydroxy-2-[2-(4′-methoxyphenyl)ethyl]ethyl]chromone}，5，8-二羟基-2-(2-对甲氧基苯乙基)色酮{5，8-dihydroxy-2-[2-(p-methoxyphenyl)ethyl]chromone}，6，7-二甲氧基-2-(2-对甲氧基苯乙基)色酮{6，7-dimethoxy-2-[2-(p-methoxyphenyl)ethyl]chromone}，5，8-二羟基-2-(2-苯乙基)色酮[5，8-dihydroxy-2-(2-phenylethyl)chromone]。
国产沉香含挥发油，其中倍半萜成分有：沉香螺醇(agarospirol)，沉香醇(agarol)，石梓呋喃(gmelo-furan)，a-及β-沉香呋喃(agarofuran)，二氢沉香呋喃(dihydroa-garofuran)，去甲沉香呋喃酮(nor-ketoagarofuran)，4-羟基二氧沉香呋喃(4-hydroxydihydroagarofuran)，3，4-二羟基二氧沉香呋喃(3，4-dihydroxydihydroagarofuran)，a-愈创木烯(a-guaiene)，a-布藜烯(a-bulnesene)，枯树醇(kusunol)，卡拉酮(karanone)，二氢卡拉酮(dihydrokaranone)，沉香螺醇醛(oxoagarospirol)，1(10)，11-愈创木二烯-15-醛[guaia-1(10)，11-dien-15-al]，3，11-芹子二烯-9-酮(seline-3，11-dien-9-one)，3，11-芹子二烯-9-醇(seline-3，11-dien-9-ol)，沉香雅槛蓝醇(jinkoheremol)等。还含其他挥发成分：苄基丙酮(benzylacetone)，对甲氧基苄基丙酮(P-methoxybenzylacetone)，氢化桂皮酸(hydrocinnamic acid)等；又含沉香木质素(aquillochin)，鹅掌揪碱(liriodenine)。另含2-(2-苯乙基)色酮类[2-(2-phenylethyl)chromone]及其二聚体、三聚体成分：AH1、AH1a、AH2、AH2a、Ah2b、AH3、AH4、AH5、AH6、AH7、AH8、AH9、A10、AH11、AH12、AH13、AH14、AH15、AH16、AH17、AH18、AH19b、AH19b、AH20、AH23，其中AH1又称为沉香四醇(agarotetrol)，AH2又称为异沉香四醇(isoagarotetrol)。
通常，沉香的使用方法有3种：a.使用电薰炉，取适量沉香片置於电薰炉的不锈钢盘内，插上电源即可；b.使用品香炉；c.沉香片冲茶法，必须挑选质量好，且无作色或上胶的沉片，尤以厚片为佳。将其用清水洗 净后放入水中煮沸，第一次煮开的沉香水中杂质较多，如灰土、虫蚁的分泌物、腐烂的植物体等，要倒掉；第二次煮沸的沉香水即可直接饮用。可用沉香水冲泡普洱、沱茶等老茶，沉香不但可去除茶中腐旧之气，而且能使老味更加深沉醇厚。沉香香材非常耐泡，一块香材往往可泡上数月之久。
发明内容
本发明的目的是提供一种沉香原液，其包括沉香挥发油和水，其中该沉香挥发油是从35-45重量份的白木香、25-35重量份的土沉香和25-35重量份的女儿香的混合物中提取得到的。
在本发明的一优选实施方式中该沉香原液，该沉香挥发油是从40重量份的白木香、30重量份的土沉香和30重量份的女儿的混合物中提取得到的。
本发明的另一目的是提供一种沉香原液的制备工艺，该工艺包括：
1)按重量计，将用清水清洗后晾干的白木香、土沉香和女儿香按一定重量比混合得到混合物；
2)将步骤1)得到的沉香混合物加入到净水中在常温下浸泡0.5-1.5个小时；
3)加热煮沸步骤2)的沉香和净水的混合物，含有沉香挥发油成分的水蒸气经冷凝管冷凝，形成沉香原液。
在本发明的一个优选实施方式中，所述净水为天然矿物质水或纯净水，其用量为沉香重量的10-15倍。
在本发明的一个优选实施例中，步骤2和步骤3是在密闭的容器中进行的。
作为本发明的第三个目的，本发明的沉香原液用于制备饮用水。
在本发明的一个优选实施方式中，该饮用水中进一步包括香料和调味剂。
在本发明的一个优选实施方式中，该饮用水中进一步包括天然防腐剂。
本发明的沉香原液还可用于食品加工中。
本发明的沉香原液还可作为茶、香料、精油等深加工工艺中的原料。
本发明的沉香原液中含有白木香、土沉香和女儿香三种沉香的提取物，虽然这三种沉香中的化学成分基本上属于相同的类型，例如，都主要有倍半萜化合物、2-(2-苯乙基)色酮、三萜类、芳香族类，脂肪酸类等，但是由于这三种沉香的具体成分的含量是有差别的，利用这三种沉香的混合物制备出来的沉香原液不但包含了这三种沉香的挥发油成分，而且，具有三种沉香的提取物的优势互补。用这三种沉香制备得到的沉香原液的香气较一般的沉香提取物的香气纯正，对中枢神经系统保护效果好，尤其对提高睡眠质量的效果尤为显著。使用GC-MS(气相色谱-质谱)对本发明的沉香原液的成分及含量行了测定(气相色谱条件：色谱柱为Varian Cpsil 5CB(30mx0.25nmx0.25nm)弹性石英毛细管；进样温度为250℃，载气是高纯氮气，流速为1.0ml/min，不分流进样；进样量为1μl，升温程序为：90℃保温4min，1℃/min升至150℃，保温25min，再以2℃/min升至180℃，最后以2℃/min升至230℃：保温70min；质谱条件是：离子源为EI源，电子能量70eV；溶剂延时4min，质量扫描范围50-500m/z全程扫描)，主要成分及含量如下。
Figure PCTCN2015000677-appb-000001
附图说明
图1为本发明沉香原液的生产流程图。
具体实施方式
本发明在以下实例中进一步说明，这些实例决不欲限制本发明的范围。
实施例1
按重量计，将用清水清洗干净，去除杂质，晾干后的40份的白木香，30份的土沉香、30份的女儿香混合成混合物；将该混合物放入蒸煮锅中加入1200份天然矿物质水或纯净水中在常温下浸泡1小时，使混合物中沉香的有益成分充分进入水中；开启蒸煮装置加热煮沸上述三种沉香和水的混合物，使沉香中的挥发油成分随着水蒸气从导流管进入冷凝管，经冷凝后在取水口取出，得到沉香原液1100mL。
制备得到的沉香原浆，加入香料、调味剂调味后装瓶，经检验合格后即可作为沉香饮用水成品。
实施例2
按重量计，将用清水清洗干净，去除杂质，晾干后的35份的白木香，33份的土沉香、32份的女儿香混合成混合物；将混合物放入蒸煮锅中加入1500份天然矿物质水或纯净水中在常温下浸泡0.8个小时，使混合物中沉香的有益成分充分进入水中；开启蒸煮装置加热煮沸上述三种沉香和水的混合物，使沉香中的挥发油成分随着水蒸气从导流管进入冷凝管，经冷凝后在取水口取出，到沉香原液1370mL。
制备得到的沉香原浆，加入香料、调味剂调味后，再加入天然防腐剂装瓶，经检验合格后即可作为沉香饮用水成品。
实施例3
按重量计，将用清水清洗干净，去除杂质，晾干后的30份的白木香，35份的土沉香、35份的女儿香混合成混合物；将该混合物放入蒸煮锅中加入 1000份天然矿物质水或纯净水中在常温下浸泡0.5个小时，使混合物中沉香的有益成分充分进入水中；开启蒸煮装置加热煮沸上述三种沉香和水的混合物，使沉香中的挥发油成分随着水蒸气从导流管进入冷凝管，经冷凝后在取水口取出，即得到沉香原液855mL。
制备得到的沉香原浆，加入香料、调味剂调味后，再加入天然防腐剂装瓶，经检验合格后即可作为沉香饮用水成品。
实施例4
按重量计，将用清水清洗干净，去除杂质，晾干后的45份的白木香，25份的土沉香、30份的女儿香混合成混合物；将该混合物放入蒸煮锅中加入1100份天然矿物质水或纯净水中在常温下浸泡1.5个小时，使混合物中沉香的有益成分充分进入水中；开启蒸煮装置加热煮沸上述三种沉香和水的混合物，使沉香中的挥发油成分随着水蒸气从导流管进入冷凝管，经冷凝后在取水口取出，得到沉香原液960mL。
制备得到的沉香原浆，加入香料、调味剂调味后装瓶，经检验合格后即可作为沉香饮用水成品。
实施例5
按重量计，将用清水清洗干净，去除杂质，晾干后的45份的白木香，30份的土沉香、25份的女儿香混合成混合物；将该混合物放入蒸煮锅中加入1400份天然矿物质水或纯净水中在常温下浸泡1.2个小时，使混合物中沉香的有益成分充分进入水中；开启蒸煮装置加热煮沸上述三种沉香和水的混合物，使沉香中的挥发油成分随着水蒸气从导流管进入冷凝管，经冷凝后在取水口取出，得到沉香原液1290mL。
制备得到的沉香原浆，加入香料、调味剂调味后装瓶，经检验合格后即可作为沉香饮用水成品。
上述实施例1-5中用到的蒸煮设备是一种圆形的蒸锅，底部有加热装置。上部有锅盖，锅盖上有铰链装置，把锅盖分为两部分，其中一部分有把手，使用者可以在使用过程中查看锅内的蒸煮情况；另一部分上端连接导流管， 是蒸汽排除的管道，导流管连接冷凝管，冷凝管的出口即为取水口。
上述实施例1-5得到的沉香原液还可作为茶、香料、精油、食品等深加工工艺中。
实施例6
改善睡眠功能实验：
实验目的：检验产品是否具有改善睡眠的功能。
实验材料：实施例1制备的原液和按实施例1的方法制备的白木香、土沉香、女儿香的原液(用同等质量白木香、土沉香、女儿香分别代替三种沉香混合物，其它条件不变，最后收集同等体积的沉香原液)。
人体口服推荐摄入量为每日三次，每次100mL(按体重60kg计)，1.7mL/kg·bw。
实验动物：清洁级ICR小鼠及饲料。
饲养条件：温度20-25℃，相对湿度40％-70％的屏障系统。
实验方法：按照《保健食品检验与评价技术规范》(2003版)评价标准进行直接催眠实验、延长巴比妥钠睡眠时间实验、巴比妥钠阀下剂量催眠实验、巴比妥钠睡眠潜伏期实验，设白木香原液组、土沉香原液组、女儿香原液组、本发明的沉香原液组和阴性对照组(无菌水)，每个组的剂量相当于人用最大推荐剂量的10倍。经口每日三次给予小鼠一定剂量的受试物，小鼠灌胃量为17mL/kg·bw。
实验结果如表4、表5和表6所示：经口给小鼠17mL/kg·bw，白木香原液、土沉香原液、女儿香原液和本发明的沉香原液都能缩短巴比妥钠诱导睡眠潜伏期(P＜0.05，0.05，0.05，0.05)，但是本发明的沉香原液效果最明显；上述四种沉香原液均能提高阀下剂量巴比妥钠诱导小鼠睡眠的发生率(P＜0.05，0.05，0.05，0.05)，但是本发明的沉香原液效果最明显；上述四种沉香原液均能延长巴比妥钠诱导的睡眠时间(P＜0.05，0.05，0.05，0.05)，但是本发明的沉香原液效果最明显。说明实施例1制备的沉香原液有改善睡眠的作用，且改善睡眠的效果较同等用量的任一种沉香的效果都好。具体实验结果数据如下：
表2，沉香原液对巴比妥钠诱导小鼠睡眠时间的影响(n＝15，x±s)
Figure PCTCN2015000677-appb-000002
表3沉香原液对阀下剂量巴比妥钠诱导小鼠睡眠发生率的影响(n＝15，x±s)
Figure PCTCN2015000677-appb-000003
表4沉香原液对巴比妥钠诱导小鼠睡眠潜伏期的影响(n＝15，x±s)
Figure PCTCN2015000677-appb-000004
对于本领域技术人员而言，显然本申请不限于上述示范性实施例的细 节，而且在不背离本申请的精神或基本特征的情况下，能够以其他的具体形式实现本申请。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限制性的，本申请的范围由所附权利要求而不是上述说明限定，因此旨在将落在权利要求的等同要件的含义和范围内的所有变化涵括在本申请内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。

Claims (9)

  1. 一种沉香原液，其包括沉香挥发油和水，其中所述沉香挥发油是从35-45重量份的白木香、25-35重量份的土沉香和25-35重量份的女儿的混合物中提取得到的。
  2. 根据权利要求1所述的沉香原液，其中所述沉香挥发油是从40重量份的白木香、30重量份的土沉香和30重量份的女儿的混合物中提取得到的。
  3. 一种权利要求1或2所述的沉香原液的制备工艺，其包括以下步骤：
    1)按重量计，将用清水清洗后晾干的白木香、土沉香和女儿香按一定重量比混合得到混合物；
    2)将步骤1)得到的沉香混合物加入到净水中在常温下浸泡0.5-1.5个小时；
    3)加热煮沸步骤2)的沉香和净水的混合物，含有沉香挥发油成分的水蒸气经冷凝管冷凝，形成沉香原液。
  4. 根据权利要求3所述的制备工艺，其中所述净水为天然矿物质水或纯净水，其用量为沉香重量的10-15倍。
  5. 根据权利要求3所述的制备工艺，其中步骤2和步骤3是在密闭的容器中进行的。
  6. 权利要求1或2所述的沉香原液在制备饮用水中的应用。
  7. 根据权利要求6所述的应用，其中所述饮用水进一步包括香料和调味剂。
  8. 根据权利要求6所述的应用，其中所述饮用水进一步包括天然防腐剂。
  9. 权利要求1或2所述的沉香原液在制备食品中的应用。
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