WO2015196538A1 - 覆膜植入系统以及覆膜和支架分别植入的植入系统、方法 - Google Patents
覆膜植入系统以及覆膜和支架分别植入的植入系统、方法 Download PDFInfo
- Publication number
- WO2015196538A1 WO2015196538A1 PCT/CN2014/084320 CN2014084320W WO2015196538A1 WO 2015196538 A1 WO2015196538 A1 WO 2015196538A1 CN 2014084320 W CN2014084320 W CN 2014084320W WO 2015196538 A1 WO2015196538 A1 WO 2015196538A1
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- WO
- WIPO (PCT)
- Prior art keywords
- film
- core
- stent
- branch
- guide
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
- A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/954—Instruments specially adapted for placement or removal of stents or stent-grafts for placing stents or stent-grafts in a bifurcation
Definitions
- the present invention relates to the field of film implantation of a stent graft, and in particular to a membrane implant system and an implant system and method for implanting a stent and a stent, respectively, using the membrane implant system. Background technique
- the aortic arch is a curved and large branch with multiple branches, wherein the three branches of the aortic arch, the left carotid artery and the left subclavian artery vary greatly, the diameters are not the same, the distance of the interval and the aortic arch
- the implanted vascular stent is a stent graft, wherein the membrane acts as an artificial blood vessel to direct blood flow into the three branches, and the stent is radially supported and anchored.
- the stent graft is implanted in such a manner that the stent and the stent are simultaneously implanted, that is, the membrane is previously coated on the stent and simultaneously implanted into the blood vessel with the stent.
- this approach has the following problems:
- the implant system of the implanted stent graft is oversized, which is not conducive to transport in the blood vessel;
- the main body and the branch of the film are difficult to locate at the three branch vessels, and the implantation is difficult;
- a film implantation system including a body guide wire, a guide core movably sleeved on the body guide wire, and Releasably receiving a sheath of the coating, the sheath being movably sleeved outside the core, wherein the membrane implant system has the membrane adjusted after the sheath releases the coating
- An adjustment mechanism for the axial position the adjustment mechanism being releasably connected to the coating.
- the cover film includes a main body portion forming a cylindrical structure
- the adjustment mechanism includes a front end control wire removably coupled to a front end of the main body portion and a steering transmission structure, wherein the front end control wire passes the The steering transmission structure is turned rearward and extended.
- the cover film includes a main body portion forming a cylindrical structure
- the adjustment mechanism includes a front end control wire releasably coupled to a front end of the main body portion, and the front end control wire is coupled to the guide core.
- the guiding sheath and the guiding core extend rearward
- the steering transmission structure is disposed on the guiding core
- the front end control wire is led out from the front end of the main body portion and then turned through the steering transmission structure It is then inserted into the core and extends rearward.
- the steering transmission structure is a steering hole structure through which the front end control wire passes.
- the guiding core is fixed with a seeker located in front of the main body portion, the seeking head is located in front of the guiding sheath and has a streamlined structure, and the steering transmission structure is disposed on the guiding head .
- the adjustment mechanism further includes a rear end control wire releasably coupled to a rear end of the main body portion, the rear end control wire extending rearward.
- the cover film includes a branch portion on which the main body portion forming the cylindrical structure is attached, the film implantation system further includes a branch guide wire penetrating into the branch portion, and the adjustment mechanism includes And a limiting hole disposed on the branching guide wire, wherein the branching portion is provided with a limiting hole in front of the limiting node, and the size of the limiting node is larger than the size of the limiting hole.
- the limiting hole is formed by a limiting ring connected to the branching portion by a connecting line, and the limiting ring is spaced apart from a front end edge of the branching portion.
- the connecting wires are plural and are detachably connected to the branch portions uniformly in the circumferential direction.
- the limit knot is detachably disposed on the branch guide wire.
- the film implant system further includes a core locking member that secures the lead core relative to the guide sheath.
- an implant system for implanting a stent and a stent, respectively comprising a membrane implant system provided by the present invention and a stent delivery device for releasably receiving and transporting the stent.
- the stent delivery device is sleeved outside the guiding core
- the implanting system further comprises a guiding core locking member for fixing the guiding core relative to the guiding sheath, the guiding core is locked
- the piece is fixedly coupled to the lead core and has a first locking portion and a second locking portion, the first locking portion and the second locking portion respectively unlockably locking the guiding core and along the guiding core
- the axial spacing is set.
- the core guiding locking member comprises a first locking position and a second locking position, wherein in the first locking position, the first locking portion is unlocked, and the first locking is located
- the second locking portion in front of the portion locks the guiding core, and the bracket conveying device sleeved on the guiding core slides along the guiding core to the first locking portion and the second locking portion
- the bracket conveying device passes through the second locking portion Move before.
- the stent delivery device is sleeved outside the guiding core
- the guiding core comprises a guide wire hole for the body guide wire to pass through, and a control wire hole disposed around the guide wire hole, wherein the control wire a hole is formed on a sidewall of the lead core and extends in the same direction as the lead core, and an outer wall of the lead core has a
- the stent delivery device is configured to be connected to a non-circular cross-sectional structure having protrusions forming the control wire holes.
- the implant system is for implanting the membrane and stent at the three branches of the aortic arch.
- an implant method for separately implanting a film and a stent comprising a step of sequentially implanting a film and a step of implanting a stent, wherein the film is implanted
- the main body guide wire is first inserted into the blood vessel, and the guide core movably sleeved in the main body guide wire is moved into the blood vessel along the main body guide wire, and then the guide film releasably accommodates the film.
- the sheath is movably sleeved outside the guiding core and moved into the blood vessel along the guiding core, and after the guiding sheath releases the coating, the axial position of the coating is adjusted by an adjusting mechanism, and the coating is After the adjustment is completed, the connection of the adjustment mechanism and the film is released.
- the forward movement of the main body portion is realized by a front end control wire that connects the front end of the main body portion and is turned rearward and extended to the outside of the body.
- the rearward movement of the main body portion is achieved by a rear end control wire that connects the rear end of the main body portion and extends rearward to the outside of the body.
- the film implantation step further comprising inserting a branching guide wire into the branch blood vessel of the blood vessel, and movably sleeved the branch portion of the coating film on the branching guide wire,
- the forward movement of the branch portion is achieved by operating the branch wire.
- the stent is releasably received in the stent delivery device, and the stent delivery device is movably sleeved on the guide core and moved along the guide core to the Laminating.
- the guiding core is always locked relative to the guiding sheath.
- the adjustment mechanism provided by the present invention and detachably connected to the film can not only adjust the axial position of the film after release, but also does not affect the normal operation of the patient's blood vessel after the adjustment is completed.
- FIG. 1 is a schematic view showing the structure of a stent graft implantation system in a three-branch vessel of aortic arch according to a preferred embodiment of the present invention
- FIG. 2 is a schematic structural view of an outer working portion of a stent graft implantation system according to a preferred embodiment of the present invention
- FIG. 3 is a schematic view showing the outer shape structure of a stent graft implantation system according to a preferred embodiment of the present invention
- FIG. 4 is a schematic structural view of a stent delivery device according to a preferred embodiment of the present invention
- FIG. 5 is a cross-sectional structural view of a guide core in a preferred embodiment of the present invention
- FIG. 6 is a schematic structural view of a film provided by a preferred embodiment of the present invention.
- Figure 7 is a cross-sectional structural view taken along line A-A of Figure 6;
- Figure 8 is a cross-sectional structural view taken along line B-B of Figure 6;
- FIG. 9 is a schematic top plan view of a stent provided by a preferred embodiment of the present invention.
- Figure 10 is a side elevational view of the stent provided by a preferred embodiment of the present invention. detailed description
- the positional words used such as “inside and outside”, generally refer to the inside and outside of the contour of the corresponding object, and "far, near” is the relative position of one component relative to another component.
- “front and back” are usually defined based on the direction in which the stent and related components are implanted along the vessel, ie, the corresponding component is advanced into the blood vessel and exits the vessel backward.
- the method for implanting the stent graft used in the present invention is to first implant the membrane, and then implant the stent after the membrane is accurately positioned, that is, the step of implanting the membrane and the stent are sequentially performed.
- the implantation step is to achieve separate implantation of the membrane and the stent, so that the membrane and the stent can accurately fit on the three branch vessel wall of the aortic arch.
- the stent graft implantation system and method provided by the invention can be used for the position of other blood vessels which need to be implanted between the membranes in addition to the three branches of the aortic arch, and the deformation of the applied position falls on the present.
- the present invention further improves the structure of the film and the stent itself.
- the present invention will be described in detail in four aspects of the film implantation, the stent implantation, the film structure and the stent structure.
- FIG. 1 schematically shows an internal part structure of a membrane implant system provided by the present invention
- FIG. 2 schematically shows The in vitro partial structure of the film implantation system provided by the present invention
- Fig. 3 schematically shows the overall outline structure of the film implantation system provided by the present invention.
- the film includes a main body portion 201 formed in a cylindrical structure and a branch portion 202 connected to the main body portion 201, wherein the number of the branch portions 202 depends on the position of the blood vessel used
- the first branch portion 2021, the second branch portion 2022, and the third branch portion 2023 are included to accommodate the innominate artery, the left-neck aorta, and the left subclavian artery, respectively.
- the film implantation method and system provided by the invention can adjust the axial position of the film at the external end.
- the axial direction position adjustment of the main body portion 201 of the film toward the both ends can be performed at one end of the outer body, for example, the rear end, and the axial position adjustment of the branch portion 202 of the film can also be performed by the guide wire of the branch blood vessel.
- the film is accurately fitted to the blood vessel walls of the three branches.
- the film implantation system provided by the invention can ensure that the position of the film which has been positioned is unchanged during the implantation process of the subsequent stent, thereby ensuring accurate positioning of the entire stent graft.
- the body guide wire 203 is first inserted into the blood vessel, and the guide core 205 movably sleeved in the body guide wire 203 is moved into the blood vessel along the body guide wire 203, and then The releasably accommodating guide sheath 206 is movably sleeved outside the guide core 205 and moved into the blood vessel along the guide core 205. After the guide sheath 206 releases the film, the axial position of the film is adjusted by the adjustment mechanism. And after the adjustment of the film is completed, the connection between the adjustment mechanism and the film is released.
- the film implantation system comprises a body guide wire 203, a branch guide wire 204, a guide core 205 and a guide sheath 206, wherein the guide core 205 is movably sleeved on the body guide wire 203.
- the guide sheath 206 houses the main body portion 201 and the branch portion 202 of the film, and the guide sheath 206 is movably sleeved outside the guide core 205.
- the film implantation system has an adjustment mechanism for adjusting the axial position of the film after the sheath 206 releases the film, and the adjustment mechanism is releasably connected to the film. Therefore, after the stent and the subsequent stent are implanted, the membrane can be released and the blood vessel can be withdrawn.
- the body guidewire 203 is preferably a superhard guidewire that can be inserted into the blood vessel from behind to serve as a guide for subsequent components.
- a guiding head 2051 located in front of the main body portion 201 of the film is fixed on the guiding core 205, and the guiding head 2051 has a conical shape or other streamlined structure to guide the guiding core 205 to non-destructively move along the blood vessel wall, wherein the guiding core
- the inside of the 205 is a hollow structure to be sleeved outside the main body guide wire 203 and axially moved along the main body guide wire 203.
- the number of the branch guide wires 204 depends on the number of branch blood vessels, and in the position of the three branch blood vessels of the aortic arch of the present invention,
- the branch guidewire 204 includes a first branch guidewire 2041, a second branch guidewire 2042, and a third branch guidewire 2043 to correspond to three branch vessels on the aorta, respectively.
- the guide sheath 206 is a hollow structure to accommodate the compressed film. And the introducer sheath 206 can be controlled by extending rearwardly beyond the outer end, such as a handle at the extracorporeal end.
- the guide sheath 206 is movably sleeved outside the guide core 205 that also extends rearwardly to be controlled to move along the guide core 205 as the guide core 205 moves synchronously.
- the front end of the guiding sheath 206 has no connection relationship with the guiding head 2051. For example, it can be positioned against the guiding head 2051 or at a certain interval from the guiding head 2051, so as to be able to control when the film needs to be released.
- the sheath 206 is withdrawn back from the membrane to release the membrane. At this time, the sheath 206 can be withdrawn to whether or not the membrane is coated for use as a channel for subsequent stent implantation.
- the adjustment mechanism provided by the present invention comprises a front end control wire 207 and a rear end control wire 208, respectively.
- the front end and the rear end of the main body portion 201 of the film are attached by means of various releasable means known in the art, such as electrolytic stripping and mechanical release, wherein the electrolytic stripping method can apply current through the relevant filaments in vitro.
- the connecting structure is melted and released to achieve a separation of the corresponding portions.
- the number of control wires and the connection position are not limited as long as the main body portion 201 of the film can be stably pulled.
- both the front end control wire 207 and the rear end control wire 208 are three, and are arranged at equal intervals along the circumferential direction of the main body portion 201, so that the body portion 201 of the film can be stably pulled toward the main body 201. Move forward or backward.
- the three rear end control wires 208 are not shown as being arranged at equal intervals in the circumferential direction, which constitutes a limitation of the present invention. .
- the adjustment structure of the present invention includes a steering transmission structure 209 that enables the corresponding control wire to be steered.
- the front end control wire can be steered rearward and backward through the steering transmission structure 209, that is, the front end of the film can be pulled at the outer end of the rear side, and combined to extend backward.
- the implant system is provided to enable pulling of the ends of the film at the outer end of the rear.
- the steering transmission structure 209 may be disposed in front of the main body portion 201 of the film.
- the front end control wire 207 may be connected to the lead core 205 in a manner of adjusting the front end of the film forward at the rear end, and specifically, may be directly connected to the lead core 205 or connected to the guide.
- the lead 2051 is connected indirectly to the core 205, so that when it is necessary to adjust the front end of the film forward, it is only necessary to push the lead 205 forward.
- the manner of pulling the rear end of the film is not limited to the use of the back end control wire 208.
- the blood vessel wall is close. Such modifications are intended to fall within the scope of the present invention.
- the front end control wire 207 is movably passed through the guide core 205, and the steering transmission structure 209 is disposed on the guide core 205, preferably on the seek head 2051.
- the steering transmission structure 209 may be a steering hole formed on the seeker 2051.
- the steering hole may be directly opened in the seeker 2051 or may be obtained by providing a guide ring connected to the seeker 2051.
- the front end control wire 207 can be drawn from the front end of the main body portion 201 of the film and then penetrated into the core 205 and extended rearward along the core 205. Therefore, when it is necessary to move the main body portion 201 to the front side, the front end control wire 207 can be pulled forward only by pulling the front end control wire 207 at the outer end of the rear side, and the overall structure is simple and ingenious.
- the rearward movement of the main body portion 201 is realized by the rear end control wire that connects the rear end of the main body portion 201 and extends rearward to the outside.
- the rear end control wire 208 can be directly coupled to the rear end of the main body portion 201 by a detachable manner, and is drawn out from the rear end and penetrates into the guide sheath 206 and extends rearward along the guide sheath 206.
- the main body portion 201 can be moved rearward by directly pulling the rear end control wire 208 backward at the outer outer end.
- the present invention provides an implant system and method that enables precise adjustment of the axial position of the body portion 201 of the membrane at an extracorporeal end.
- the branch portion 202 of the film is movably sleeved on the branch wire 204, wherein the idea of the present invention is to adjust the axial position of the branch portion of the film.
- the forward movement of the branch portion 202 is achieved by operating the branch guide wire 204. Specifically, due to the presence of the main body portion 201, the implantation system only needs to pull the branch portion 202 forward to fit the blood vessel wall without pulling the branch portion 202 rearward.
- the present invention creatively utilizes the branch guidewire 204 to adjust the axial position of the branch portion 202, wherein the branch guidewire 204 penetrates into the rearwardly extending guide sheath 206 to extend rearwardly along the introducer sheath 206.
- the adjusting mechanism includes a limiting knot 211 disposed on the branching guide wire 204, and the limiting portion hole 210 is disposed on the branching portion 202, wherein the limiting node 211 is The size is larger than the size of the limiting hole 210, and the limiting hole 210 is located in front of the limiting node 211. In this way, when the branch portion 202 needs to be pulled forward, the branch wire 204 is only pulled forward, and the limit node 211 is caught on the limiting hole 210 to drive the branch portion 202 to move forward.
- the limiting knot 211 can be formed by winding two guide wires or by connecting additional components on the guide wire.
- the limiting knot 211 is detachably disposed in the branching guide wire 204, for example, the two guide wires are wound in a detachable manner (electrolytic removal, mechanical release, etc.). Whether the limit junction 211 needs to be disengaged from the branch guide wire 204 depends on the final withdrawal mode of the branch guide wire 204. If the branch guide wire 204 is withdrawn from the front, the limit junction 211 is required to be associated with the branch guide wire 204. In the detachable manner, if the branching wire 204 is withdrawn from the rear, the limiting knot 211 and the branching guide wire 204 are not required to be released, and the branching guide wire 204 can be directly withdrawn from the rear.
- the limiting hole 210 may be formed by connecting a limiting ring on the branch portion 202, and the limiting ring may be formed by a metal that can be implanted into a human body. Due to the small size, the limit ring can be placed in the patient with the film without causing vascular disease.
- the limiting ring is preferably connected to the branching portion 202 by a connecting wire so as to be spaced apart from each other, which can reduce the abrasion of the branching wire 202 by the branching wire 204.
- the portion 202 has a plurality of connecting lines and is detachably connected to the branch portion 202 in the circumferential direction, so that the limiting ring is located at a radial center of the branch portion 202, so that the branching guide wire 204 pulls the branch portion 202 more efficiently.
- the connecting line can be released from the branching portion 202, so that after the release, the limiting ring can be withdrawn forward with the branching guide wire 204, and the limit knot can be released without the limit. In this way, after the limit ring is withdrawn, it will not interfere with the circulation of blood in the blood vessels in the later stage.
- the limit junction 211 and the limiting hole 210 have other modifications, and various modifications are within the scope of the present invention without departing from the concept of the present invention.
- the inner wall of the guiding sheath 206 may be extended along the extending direction of the guiding sheath 206.
- the guidewire receiving slots allow the corresponding wires to extend only over the inner wall of the introducer sheath 206 without affecting the stent implantation through the introducer sheath 206 at a later stage.
- the extracorporeal control portion includes a wire fixing member 212 that releasably fixes the corresponding control wire and the guide wire, and the guide core 205 is opposed to the
- the guide sheath 206 is fixed with a guide core locking member 213, wherein the number of the wire fixing members 212 depends on the number of the guide wires and the control wires used in the present invention, and the structure thereof is known to those skilled in the art, for example, fixing.
- the structure of the plug, that is, the corresponding wire is fixed on the fixed plug.
- the fixing plug can be inserted and fixed on the fixed base such as the handle, and various deformation modes of the wire fixing member 212 are required. All fall within the scope of protection of the present invention.
- the guiding sheath 206 is removed from the film and the film is controlled by the front end control wire 207, the guiding core 205 where the steering transmission structure 209 is located needs to be fixed.
- the guiding core locking member 213 is opposite to the guiding core 205.
- the guide sheath 206 is fixed.
- the guide sheath 206 is extended to the outer end and then fixed to the base such as the handle, so that the position of the guide core 205 can also be fixed.
- the core locking member 213 will be described in detail below in connection with the respective implantation of the film and the stent.
- the stent delivery device 214 is configured to releasably receive and transport the stent, and the stent delivery device can adopt the implantation method of various stents in the field. Store, transport and release.
- the stent is releasably received in the stent delivery device 214, and the stent delivery device 214 is movably sleeved on the guide core 205 and moved along the guide core 205 to the overlay. membrane.
- the guide core 205 in the film implantation system is used as a guide guide wire for guiding the movement of the stent delivery device when the stent is implanted, and the stent delivery device 214 is movably sleeved in the
- the guide core 205 is external and can and can be moved within the guide sheath 206 after the release of the film, so that the respective implantation processes of the film and the stent can be organically combined to enable efficient implantation of the stent graft.
- the core locking member 213 provided by the present invention employs a special structure. Specifically, the guiding core locking member 213 is fixedly connected to the guiding sheath 206 and has a first locking portion 2131 and a second locking portion 2132. The first locking portion 2131 and the second locking portion 2132 are respectively unlockably locked.
- the cores 205 are disposed at intervals along the axial direction of the lead core 205.
- the guiding core 206 can be fixedly connected to the guiding sheath 206, or can be an indirect fixed connection.
- the guiding sheath 206 and the guiding core locking member 213 can be fixed on the base of the operating handle, etc.
- the rear end of the ground guiding sheath 206 is fixed to the operating handle, and the front end of the guiding core locking member 213 is fixed on the operating handle, thereby achieving an indirect fixed connection of the guiding core locking member 214 and the guiding sheath 206.
- the rear end of the guiding core 205 passes through the rear end of the guiding sheath 206, and the first locking portion 2131 and the second locking portion 2132 are unlockably locked to the portion of the guiding core 205 extending from the guiding sheath 206, respectively. on.
- the core guiding member 213 includes a rod-shaped body fixedly connected to the guiding sheath 206, and the first locking portion 2131 and the second locking portion 2132 are respectively disposed in a rod shape.
- the main body is spaced apart along the length direction of the rod-shaped main body, and the two locking portions respectively unlockably lock the guide core 205 and are spaced apart along the axial direction of the guide core 205.
- the first locking portion 2131 and the second locking portion 2132 extend in the same direction from the rod-shaped body toward the guiding core 205, and a lock that unlockably locks the guiding core 205 is provided at an end away from the rod-shaped body. Tight structure.
- the locking structure of the two locking portions may be various.
- the locking structure is a thread locking member
- the guiding core 205 is correspondingly formed with the thread locking member.
- the threaded holes i.e., the locking structure with the bolt structure, are inserted or removed to the corresponding locking holes on the guiding core 205.
- Various other locking methods known in the art fall within the scope of the present invention.
- the guiding core locking member 213 includes a first locking position and a second locking position, and the first locking portion 2131 is in the first The locking state of the locking position and the second locking position are different, and the locking state of the second locking portion 2132 in the first locking position and the second locking position is different from that of the first locking portion 2131. . That is, when it is necessary to implant the bracket through the guide core 205, it is only necessary to sequentially unlock the two locking portions and ensure that the locking state and the unlocking state of the two locking portions are different.
- the first locking portion 2131 is unlocked, and the second locking portion 2132 located in front of the first locking portion 2131 locks the guiding core 205, and the bracket sleeved on the guiding core 205
- the conveying device slides along the guiding core 205 between the first locking portion 2131 and the second locking portion 2132.
- the first locking portion 2131 locks the guiding core 205, and the second locking portion 2132 is unlocked.
- the stent delivery device is moved forward by the second locking portion 2132 to reach a predetermined position within the film.
- bracket conveying device that extends out of the body to be controlled
- the locking of the lead core 205 of the first locking portion 2131 is hindered.
- the bracket can smoothly pass through the two locking portions in the unlocked state, and the locking state can keep the guiding core 205 and the guiding sheath 206 in a relatively fixed position, so that the position of the film is
- the stent is always guaranteed to remain unchanged during the implantation process.
- the method of separately implanting the membrane and the stent ensures that the stent can be accurately attached to the corresponding three branches of the aortic arch together with the membrane after implantation.
- the stent delivery device 214 includes a stent sheath 217, a stent core 216, and a stent core 215.
- the bracket is compressed and received in the bracket guide sheath 217 and sleeved outside the bracket core 216, and the bracket core 215 is movably sleeved between the bracket core 216 and the bracket guide sheath 217 and located at the rear end of the bracket, wherein
- the stent core 215, the stent sheath 217, and the stent core 216 can each extend rearward to the extracorporeal end for control and a stent guide 219 having a streamlined structure is secured to the front end of the stent core 215.
- the stent core 216 is slidably sleeved outside the lead core 205 to allow the stent delivery device 214 to enter the guide sheath 206 and move forward by operating the stent sheath 217, the stent core 216 And the stent core 215 implants the stent into the corresponding position. After the operation bracket is transported to the corresponding position, it is ensured that the stent core 215 is not moved and the stent guide sheath 217 is withdrawn backward, so that the stent can be deployed and attached to the film.
- the stent is implanted by withdrawing the stent core 215, the stent core 216 and the stent sheath 217 rearward. It should be noted that the stent sheathing device 217, the stent core 216 and the stent core 215 are not longer than the first locking portion 2131 and the second locking portion 2132. None interfere with the normal operation of the lead lock member 213.
- the present invention further improves the core 205 in view of the need for the front end control wire 207 to be movably passed through the lead core 205 and the bracket needs to be implanted along the lead core 205.
- the guiding core 205 includes a guide wire hole 2051 through which the main body guide wire 203 passes and a plurality of control wire holes 2052 disposed around the guide wire hole 2051, wherein the control wire hole 2052 is formed in the guide core 205.
- the outer wall of the guide core 205 has a non-circular cross-sectional structure having projections forming the control wire aperture 2052.
- the triangular structure shown in FIG. 5 is not limited thereto. Therefore, the projections through this non-circular cross-sectional structure are not only Control wire apertures 2052 can be formed to accommodate control wires such as front end control wires 207, and as long as the inner wall of stent guide core 216 in stent delivery device 214 is designed to positively mate with the outer wall of the lead core 205, both in guide core 205 and The bracket guiding core 216 bracket establishes a profile connection relationship, so that by rotating the guiding core 205, the rotating bracket conveying device 214 can be simultaneously realized, thereby realizing the adjustment of the circumferential position of the bracket, so that the positioning accuracy of the bracket can be more ensured.
- the guiding core 205, the guiding sheath 206, various wires and the stent delivery device of the membrane implantation system can be evacuated backward of the human blood vessel, thereby completing the present invention.
- Implantation of a stent graft It should be noted that, in the method for implanting the stent graft of the present invention, the stent can be implanted by other stent implantation techniques well known in the art, and the method of implanting the branch vessel disclosed in FIG. 1 can also be used.
- the deformation of the various stent implants falls within the scope of the present invention.
- the present invention in order to accommodate various shapes, sizes and angles of the three branches of the aortic arch, the present invention has also been successfully modified to accommodate expansion and contraction in all directions. Different coatings are not required for individual vascular characteristics.
- the present invention also provides a film covering of a stent graft.
- the film-coated body of the film comprises a body portion 201 and a branch portion 202 connected to the body portion 201 and communicating with the body portion 201.
- the body portion 201 is at least partially topographical.
- a first corrugated structure capable of being compressed in the axial direction thereof is formed, and a curved pattern 220 is further formed on the film, the curved pattern 220 extending from the branch portion 202 to the main body portion 201, and, as shown in FIGS. 7 and 8
- the curved pattern 220 is configured as a second corrugated structure that enables the body portion 201 and the branch portion 202 to be compressed perpendicular to the direction in which the arcuate lines 220 extend.
- the curved lines on the left side of the main body portion 201 are capable of indicating
- the curved portion 220 of the other portion adopts a simple drawing method capable of indicating the extending direction thereof, and the contrasting drawing method can clearly show that the curved pattern 220 can make the main body portion pass through.
- the 201 and the branch portion 202 are formed as a corrugated structure that is compressed perpendicular to the extending direction of the curved line 220.
- the end of the body portion 201 is axially compressible by the first corrugated structure, and the arcuate pattern 220 enables the end portion to be radially compressed. Therefore, the main body portion having the first corrugated structure and the second corrugated structure provided by the present invention can be arbitrarily deformed in the axial direction and the radial direction, and the main body portion forming the first corrugated structure can also be formed according to the characteristics of the corrugated structure. Bending occurs in the axial direction, so that it is possible to fully adapt to the deformation of the shape, size and angle of the blood vessel wall of the main blood vessels in various branch vessels.
- the branch portion 202 is formed as a third corrugated structure which is compressible in the axial direction thereof, and therefore, the film provided by the present invention is also capable of adapting to the angle and dimensional deformation of the blood vessel wall of the branch vessel in the branch blood vessel.
- the main body portion 201 between the end portion of the main body portion 201 and the branch portion 202 is formed as a first corrugated structure, and more preferably, at the branch portion 202.
- the first corrugated structure is formed.
- the film provided by the present invention further includes a plurality of tightening wires 211 disposed on the first corrugated structure and/or the second corrugated structure and/or the third corrugated structure, and each of the tightening wires 211 is respectively fixed at the first On the crests of the corrugated structure and/or the second corrugated structure. Therefore, when it is required to compress the corresponding corrugated structure on the film, it is only necessary to tighten the tightening line 211 on the peak of the corresponding position and tighten it, so that the tightening line 211 provided at different positions can be covered.
- the change in size of the film in the axial direction and the radial direction that is, the inner diameter and length of the main body portion 201 and the branch portion 202, the inclination angle of the branch portion 202 with respect to the main body portion 201, the spacing between the branch portions 202, and the like can be adjusted.
- the tightening wire 211 is fixed on the peak located at the corner of the curved line 220, that is, formed on the second corrugated structure, wherein the corner position is the corner position in the extending direction of the curved line 220 (see The tightening line 221) identified in the lower part of FIG. 6 is located at a position aligned with the branch portion 202 on the main body portion 201.
- the tightening wire 211 can be tightened not only to the left to control the length of the main body portion, but also upward.
- the lower beam is tightened to control the diameter of the main body portion, and can also be tightened to the right to control the spacing between the branch portions 202, and to tighten the tightening line with the upward and branch portions 202 to control the inclination angle of the branch portion 202, that is, the corner.
- the tightening portion of the position can be tightened with the tightening wire 211 located in any direction around it, so that the diameter, the length of the main body portion 201 of the film and the angle of the branch portion 202 can be completed by the tightening wire 211 located at the corner. Adjustment.
- the film provided by the present invention can perform secondary processing on the film according to the characteristics of the patient's blood vessels in vitro, so that the film can be more adapted to different human blood vessels, and it is not necessary to customize different films for different people, and the cost is low. Practicality.
- the specification of the corrugated structure on the film according to the present invention depends on the shape of the blood vessel to be used, and the film provided by the present invention can be formed by hot pressing of a polymer material such as PTFE which can be implanted into the human body, for the size of the film.
- a polymer material such as PTFE which can be implanted into the human body, for the size of the film.
- Various modifications of the specifications, materials, and the like fall within the scope of the present invention.
- the present invention also improves the stent in the stent graft.
- the branch portion 202 of the film if the stent for supporting and anchoring the film adopts a monolithic structure, it will cause a hole resistance to the branch portion and affect the blood flow of the branch portion. Therefore, in the prior art, separate stents are respectively implanted at both ends of the membrane, so that the anchoring and anchoring of the membrane can be anchored, and the blood flow of the branch can be kept unobstructed. However, this will cause the implantation process of the stent to be cumbersome and inconvenient.
- the integral bracket is employed in the present invention and the problem of the hole resistance to the branch portion can be effectively avoided.
- the stent provided by the present invention includes a stent body 230, and the stent body 230 is formed with a branch portion 202 corresponding to the coating film. Notch portion 233. Therefore, due to the presence of the notch portion 233, no pore resistance is caused to the film branching portion 202, and support and anchoring of the film are completed by one bracket.
- bracket can be used.
- a type of bracket that is, the notch portion 233 and the branch portion 202 correspond. Otherwise, such a bracket having the notch portion 233 is not used if the circumferential direction of the bracket cannot be secured.
- the branch guide wire in order to ensure the circumferential positioning of the stent, can be inserted into the notch portion 233, so that the circumferential direction of the notch portion 233 can be substantially determined to correspond to the branch portion 202.
- the stent enters the film, it can also By rotating the guide core by the unique core rotation method of the present invention, the holder is rotated, thereby ensuring that the notch portion 233 and the branch portion 202 are completely corresponding.
- the notch portion 233 can be designed according to the size and number of the branch portions 202, and the size and the number of deformations of the notch portion 233 fall within the protection scope of the present invention.
- the holder main body 230 includes a loose portion 232 between the dense portion 231 at both ends and the dense portion, wherein the dense portion 231 has a skeleton density larger than that of the loose portion 232, and the notch portion 233 is formed on the loose portion 232.
- the skeletal density referred to herein refers to the density of the wire (e.g., wire) designed at the corresponding position when the stent is manufactured.
- the dense portion 231 at both ends can function as a radial support for the stent body 230, and the loose portion 232 located at the middle can more reliably prevent the pore resistance of the denser wire to the blood vessel, which is more favorable for the normal blood vessel of the human body. jobs.
- the dense portions 231 located at both ends have the same skeleton density.
- the holder main body 230 is formed in a straight cylindrical structure and is composed of two dense portions 231 and one loose portion 232.
- the ratio of the length of the dense portion 231 and the loose portion 232 is 1:3-1:2.
- the skeleton density of the loose portion 230 is uniformly distributed in the axial direction, The ratio of the density of the loose portion 232 to the skeleton density of the dense portion 231 is 1: 1 : 10-1: 2.
- the bulk density of the loose portion 231 is unevenly distributed, but the density of the skeleton from the axial center toward both ends is gradually increased.
- the stent provided by the present invention better supports the blood vessel, and the effect is effective to effectively solve the problem of occurrence of the pore resistance.
- the stent body 230 can be woven into a Z-shaped compressible structure using a wire material such as metal tantalum, medical stainless steel, or nickel-titanium alloy, and various modifications known in the art for the material and the compressed structure fall within the scope of the present invention.
- the notch portion 233 may be one and simultaneously for three branch vessels, and may also correspond to a plurality of branch vessels respectively, and such deformations fall within the present invention. In the scope of protection.
- the present invention focuses on an implant system, method, and a film and a stent for a stent graft for a three-branch vessel of the aortic arch, which enables accurate positioning of the membrane and the stent, and is simple in structure and convenient to operate. It has high practicality and promotion value.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14894193.3A EP3017789B8 (en) | 2014-06-25 | 2014-08-13 | Cover implantation system, and implantation system for separately implanting cover and stent |
JP2016530344A JP6395831B2 (ja) | 2014-06-25 | 2014-08-13 | 被膜植え込みシステム、および、被膜とステントとをそれぞれ植え込むシステム |
US14/895,909 US10327930B2 (en) | 2014-06-25 | 2014-08-13 | System for implanting membrane, system and method for implanting membrane and stent respectively |
ES14894193.3T ES2663524T3 (es) | 2014-06-25 | 2014-08-13 | Sistema de implante de cubiertas, y sistema de implante para implantar por separado la cubierta y el stent |
Applications Claiming Priority (2)
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CN201410293146.X | 2014-06-25 | ||
CN201410293146.XA CN105310798B (zh) | 2014-06-25 | 2014-06-25 | 覆膜植入系统以及覆膜和支架分别植入的植入系统 |
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WO2015196538A1 true WO2015196538A1 (zh) | 2015-12-30 |
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PCT/CN2014/084320 WO2015196538A1 (zh) | 2014-06-25 | 2014-08-13 | 覆膜植入系统以及覆膜和支架分别植入的植入系统、方法 |
Country Status (6)
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US (1) | US10327930B2 (zh) |
EP (1) | EP3017789B8 (zh) |
JP (1) | JP6395831B2 (zh) |
CN (1) | CN105310798B (zh) |
ES (1) | ES2663524T3 (zh) |
WO (1) | WO2015196538A1 (zh) |
Cited By (1)
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CN108245280A (zh) * | 2016-12-29 | 2018-07-06 | 先健科技(深圳)有限公司 | 覆膜支架 |
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WO2019227357A1 (zh) * | 2018-05-30 | 2019-12-05 | Li Lei | 分支血管的支架精准植入系统的操作装置 |
CN110507448B (zh) * | 2019-08-22 | 2020-06-23 | 胡锡祥 | 一种主动脉弓覆膜支架血管 |
CN110495969B (zh) * | 2019-09-17 | 2022-12-20 | 侯红军 | 主动脉弓-胸主动脉滑道调控预开窗覆膜支架 |
CN111419495A (zh) * | 2019-10-28 | 2020-07-17 | 上海宏派医疗科技有限公司 | 一种新型自膨式血管支架输送系统 |
CN114587731A (zh) * | 2022-04-13 | 2022-06-07 | 郑州大学第一附属医院 | 一种血管支架辅助调节装置 |
CN117442403B (zh) * | 2023-12-25 | 2024-03-15 | 北京华脉泰科医疗器械股份有限公司 | 可顺序释放的一体式带分支主动脉支架及支架输送器 |
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US20170105859A1 (en) | 2017-04-20 |
CN105310798A (zh) | 2016-02-10 |
EP3017789A4 (en) | 2016-08-24 |
ES2663524T3 (es) | 2018-04-13 |
EP3017789B8 (en) | 2018-04-18 |
US10327930B2 (en) | 2019-06-25 |
EP3017789B1 (en) | 2017-12-20 |
CN105310798B (zh) | 2017-10-17 |
JP6395831B2 (ja) | 2018-09-26 |
EP3017789A1 (en) | 2016-05-11 |
JP2016525007A (ja) | 2016-08-22 |
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