WO2015194645A1 - ブリスターパック用吸収層、それを含む積層体、及びそれを用いたブリスターパック - Google Patents
ブリスターパック用吸収層、それを含む積層体、及びそれを用いたブリスターパック Download PDFInfo
- Publication number
- WO2015194645A1 WO2015194645A1 PCT/JP2015/067659 JP2015067659W WO2015194645A1 WO 2015194645 A1 WO2015194645 A1 WO 2015194645A1 JP 2015067659 W JP2015067659 W JP 2015067659W WO 2015194645 A1 WO2015194645 A1 WO 2015194645A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- layer
- laminate
- inner skin
- skin layer
- blister pack
- Prior art date
Links
- 239000002250 absorbent Substances 0.000 title claims abstract description 49
- 230000002745 absorbent Effects 0.000 title claims abstract description 49
- 229920005989 resin Polymers 0.000 claims abstract description 50
- 239000011347 resin Substances 0.000 claims abstract description 50
- -1 polypropylene Polymers 0.000 claims abstract description 36
- 239000004743 Polypropylene Substances 0.000 claims abstract description 30
- 229920001155 polypropylene Polymers 0.000 claims abstract description 30
- 229920001903 high density polyethylene Polymers 0.000 claims abstract description 23
- 239000004700 high-density polyethylene Substances 0.000 claims abstract description 23
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 claims abstract description 9
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 claims abstract description 9
- 239000011230 binding agent Substances 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims description 45
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 39
- 229910052782 aluminium Inorganic materials 0.000 claims description 39
- 238000010521 absorption reaction Methods 0.000 claims description 32
- 230000002787 reinforcement Effects 0.000 claims description 4
- 239000010410 layer Substances 0.000 description 237
- 238000000465 moulding Methods 0.000 description 21
- 238000000034 method Methods 0.000 description 19
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 16
- 239000010457 zeolite Substances 0.000 description 16
- 229910021536 Zeolite Inorganic materials 0.000 description 15
- 239000003814 drug Substances 0.000 description 12
- 239000002808 molecular sieve Substances 0.000 description 11
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 11
- 229940079593 drug Drugs 0.000 description 10
- 230000003014 reinforcing effect Effects 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 230000003746 surface roughness Effects 0.000 description 8
- 230000005484 gravity Effects 0.000 description 6
- 230000002209 hydrophobic effect Effects 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 239000004800 polyvinyl chloride Substances 0.000 description 6
- 239000004698 Polyethylene Substances 0.000 description 5
- 230000007547 defect Effects 0.000 description 5
- 238000007373 indentation Methods 0.000 description 5
- 239000008188 pellet Substances 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 229920006395 saturated elastomer Polymers 0.000 description 5
- 229920006305 unsaturated polyester Polymers 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 239000005038 ethylene vinyl acetate Substances 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 229920000092 linear low density polyethylene Polymers 0.000 description 4
- 239000004707 linear low-density polyethylene Substances 0.000 description 4
- 235000019645 odor Nutrition 0.000 description 4
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 4
- 229920013716 polyethylene resin Polymers 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000004952 Polyamide Substances 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 3
- 239000002274 desiccant Substances 0.000 description 3
- 238000009820 dry lamination Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 229920002647 polyamide Polymers 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920005673 polypropylene based resin Polymers 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 229920005992 thermoplastic resin Polymers 0.000 description 3
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000000292 calcium oxide Substances 0.000 description 2
- 235000012255 calcium oxide Nutrition 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229920006242 ethylene acrylic acid copolymer Polymers 0.000 description 2
- 229920005648 ethylene methacrylic acid copolymer Polymers 0.000 description 2
- 229920006244 ethylene-ethyl acrylate Polymers 0.000 description 2
- 229920006225 ethylene-methyl acrylate Polymers 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 238000003475 lamination Methods 0.000 description 2
- 238000007561 laser diffraction method Methods 0.000 description 2
- 229920001684 low density polyethylene Polymers 0.000 description 2
- 239000004702 low-density polyethylene Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007721 medicinal effect Effects 0.000 description 2
- 229920001179 medium density polyethylene Polymers 0.000 description 2
- 239000004701 medium-density polyethylene Substances 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229920001707 polybutylene terephthalate Polymers 0.000 description 2
- 238000000790 scattering method Methods 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- RTTZISZSHSCFRH-UHFFFAOYSA-N 1,3-bis(isocyanatomethyl)benzene Chemical compound O=C=NCC1=CC=CC(CN=C=O)=C1 RTTZISZSHSCFRH-UHFFFAOYSA-N 0.000 description 1
- 208000032484 Accidental exposure to product Diseases 0.000 description 1
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229920010126 Linear Low Density Polyethylene (LLDPE) Polymers 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229920002292 Nylon 6 Polymers 0.000 description 1
- 229920002302 Nylon 6,6 Polymers 0.000 description 1
- 229920000007 Nylon MXD6 Polymers 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910001579 aluminosilicate mineral Inorganic materials 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000005042 ethylene-ethyl acrylate Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920002493 poly(chlorotrifluoroethylene) Polymers 0.000 description 1
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 description 1
- 229920005678 polyethylene based resin Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
- 238000007666 vacuum forming Methods 0.000 description 1
Images
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
- B65D65/38—Packaging materials of special type or form
- B65D65/40—Applications of laminates for particular packaging purposes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/34—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents and having several recesses to accommodate a series of articles or quantities of material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
Definitions
- the present invention relates to an absorbent layer for a blister pack, a laminate including the same, and a blister pack using the laminate.
- the present invention uses an absorbent layer for a blister pack that does not cause molding defects even when a pocket portion having a depth is formed for packaging a large drug, a laminate including the same, and the laminate.
- blister packs Regarding blister packs.
- Powdered drugs are enclosed in thin paper bags or film bags, while drugs such as tablets or capsules are enclosed in blister packs called PTP (press-through packs).
- PTP press-through packs
- ⁇ Drugs may alter the medicinal properties by absorbing moisture. Therefore, conventionally, a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack.
- a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack.
- the operation of putting the desiccant into the outer bag takes time and there is a risk of accidental ingestion or accidental eating.
- the inside of the blister pack cannot be kept at a low humidity, and there is a problem in that the deterioration of the drug progresses.
- some chemicals are easily oxidatively decomposed, and others emit a specific odor. Therefore, there is a demand for absorbing gas such as oxygen and odor in the blister pack.
- Patent Document 1 discloses a technique for improving the long-term stability of a drug by forming an absorbent layer having an absorbent inside a blister pack.
- a dome-shaped pocket portion is formed in a laminate of a base material and an absorption layer which are barrier layers.
- medical agent which is a tablet is put into the pocket part, and this is sealed with the cover material. According to this technology, it is considered that it is possible to maintain a dry state, prevent oxidation, and efficiently remove odors without enclosing a desiccant or the like in the outer bag.
- Patent Document 1 further discloses a technique for forming an aluminum layer not only on the cover material on the back side of the blister pack but also on the front blister pack laminate, so-called aluminum blister packaging. According to this technique, since the aluminum layer is formed on the blister pack, the drug cannot be visually recognized, but the ultraviolet ray can be blocked and the barrier property can be further enhanced.
- Patent Document 2 inserts a reinforcing layer using a specific polymer between the aluminum layer and the absorbing layer.
- the shoulder portion of the pocket may tear or a pinhole may occur depending on the mold or molding depth of the molding machine.
- the present invention relates to an absorbent layer for blister packs that does not cause molding defects even when pockets are formed to a certain depth and that provides sufficient formability, a laminate including the same, and a blister using the laminate.
- the purpose is to provide a pack.
- Outer skin layer For blister packs comprising an intermediate layer having an inorganic absorbent and a binder resin; and an inner skin layer having a high density polyethylene and a polypropylene resin in this order and satisfying at least one of the following conditions (a) to (c) Absorption layer: (A) the inner skin layer contains 3 to 70% by weight of high density polyethylene and 97 to 30% by weight of a polypropylene resin; (B) Arithmetic mean roughness Ra of the surface of the inner skin layer opposite to the intermediate layer when measured according to ISO 4287 is 0.40 ⁇ m or more; and (c) According to ISO 8295 The dynamic friction coefficient of the inner skin layer with the ultra high molecular weight polyethylene when measured is 0.200 or less.
- a blister pack package comprising the blister pack according to [9] and the contents stored in the pocket portion.
- the absorbent layer for blister packs of the present invention includes an outer skin layer, an intermediate layer containing an inorganic absorbent and a binder resin, and an inner skin layer in this order. Since the inorganic absorbent contained in the intermediate layer is prevented from being detached during use and the absorbent layer can be easily produced, it is sandwiched between the upper and lower skin layers.
- the outer skin layer is a layer used on the side (outside) opposite to the side into which the contents of the blister pack are put, and the inner skin layer is a layer used on the side into which the contents are put (inside).
- the blister pack absorbent layer 4 of the present invention can be used by being laminated with the base material layer 2 and the aluminum layer 3 in the blister pack 1 of the present invention.
- the blister pack absorbent layer 4 of the present invention has an outer skin layer 41, an intermediate layer 42, and an inner skin layer 43.
- An absorption layer including an outer skin layer, an intermediate layer, and an inner skin layer can be manufactured by an inflation method.
- This is a method for producing a multilayer film by extruding a plurality of resins into a tube shape at the same time by a plurality of extruders and sending the air into the tubes to inflate them.
- the intermediate layer of the absorbent layer is formed into a film or sheet by extrusion or injection molding such as inflation method, T-die method, coextrusion, etc., and the outer skin layer and inner skin layer are formed into a film by a known method. Then, the absorbent layer can be manufactured by laminating the intermediate layer.
- Examples of the molding method for molding the pocket portion of the blister pack include a flat plate air forming method, a plug assist pressure forming method, a drum type vacuum forming method, and a plug forming method.
- a plug molding method using a cylindrical rod (plug material) having a round tip at a viscosity average molecular weight of 1 million or more is preferable for forming a pocket.
- a crack may occur in the shoulder portion or the skirt portion of the dome-shaped pocket portion.
- the blister pack laminate is cracked with high probability when the pocket portion is formed. Found that occurs. That is, when the friction between the plug material and the inner skin layer is large, only the contact portion between the plug material and the inner skin layer is greatly stretched, and it is considered that a large tensile stress is generated in the laminated body and a crack is generated. .
- the present inventors make the surface of the inner skin layer of the absorption layer easy to slide with the plug material, so that when the plug material is pushed into the inner skin layer, the entire pushing surface is strained as uniformly as possible, The present invention has been achieved.
- the inner skin layer contains high-density polyethylene and polypropylene-based resin and satisfies at least one of the following conditions (a) to (c): (A) containing 3 to 70% by weight of high density polyethylene and 97 to 30% by weight of polypropylene resin; (B) Arithmetic mean roughness Ra of the surface opposite to the intermediate layer when measured according to ISO 4287 is 0.40 ⁇ m or more; and (c) Ultra high when measured according to ISO 8295 Coefficient of dynamic friction with molecular weight polyethylene is 0.200 or less.
- a blister pack with an absorbent layer having a deep pocket can be produced while minimizing the occurrence of molding defects. it can.
- the high density polyethylene means a polyethylene having a density measured in accordance with JIS K6922-1 of 920 kg / m 3 or more, and this is generally a linear unit in which ethylene as a repeating unit has almost no branching. Bonded crystalline polyethylene.
- a preferred high density polyethylene has a density measured according to JIS K6922-1 of 942 kg / m 3 or more.
- the high density polyethylene used in the present invention may have a melt flow rate (MFR) measured in accordance with JIS K6922-1 in the range of 0.05 to 30 g / 10 min, preferably 0.10 to 10.0 g / The range is 10 min, more preferably 0.20 to 5.0 g / 5 min, and still more preferably 0.50 to 3.0 g / 10 min.
- MFR melt flow rate
- a polypropylene resin is a resin containing a propylene group repeating unit in a polymer main chain of 30 mol% or more, 40 mol% or more, 50 mol% or more, 60 mol% or more, 70 mol% or more, or 80 mol% or more.
- examples include polypropylene (PP) homopolymer, random polypropylene (random PP), block polypropylene (block PP), chlorinated polypropylene, carboxylic acid-modified polypropylene, and derivatives thereof, and mixtures thereof.
- the polypropylene resin used in the present invention may have a melt flow rate (MFR) measured in accordance with JIS K7210 in the range of 0.5 to 100 g / 10 min, preferably in the range of 1.5 to 50 g / 10 min. More preferably, it is in the range of 3.0 to 20 g / 10 min, and still more preferably in the range of 5.0 to 15 g / 10 min.
- MFR melt flow rate
- the inner skin layer is provided with appropriate elasticity in the inner skin layer by including 3 to 70% by weight of high density polyethylene and 97 to 30% by weight of polypropylene resin in the inner skin layer. And the friction between the plug member and the plug member can be reduced.
- the inner skin layer comprises 5 to 65 wt% high density polyethylene and 95 to 35 wt% polypropylene-based resin, most preferably 25 to 50 wt% high density polyethylene and 75 to 50 wt%. Contains polypropylene resin.
- the arithmetic average roughness Ra of the surface on the opposite side of the intermediate layer of the inner skin layer when measured according to ISO 4287 is 0.40 ⁇ m or more, preferably 0.45 ⁇ m or more, more preferably Is 0.50 ⁇ m or more, more preferably 0.55 ⁇ m or more.
- the surface roughness is large, the contact area between the inner skin layer and the plug material is reduced, so that the friction with the plug material is reduced, and the local strain at the contact portion between the plug material and the inner skin layer is reduced. Less likely to occur.
- the arithmetic surface roughness Ra is preferably 1.50 ⁇ m or less, more preferably 1.30 ⁇ m or less, and even more preferably 1.00 ⁇ m or less.
- the dynamic friction coefficient ( ⁇ D) between the ultrahigh molecular weight polyethylene and the inner skin layer when measured in accordance with ISO8295 is 0.200 or less, preferably 0.190 or less, more preferably 0. .185 or less, more preferably 0.180 or less, and most preferably 0.175 or less.
- the ultra high molecular weight polyethylene is a polyethylene having a viscosity average molecular weight of 1 million or more measured based on JIS K7367-3: 1999, and particularly an ultra high molecular weight polyethylene resin having a molecular weight of 5.5 million (product name: Neulite ( Trademark) NL-W (manufactured by Sakushin Kogyo Co., Ltd.).
- the inner skin layer contains high-density polyethylene and polypropylene-based resin, but may further contain other resins within the range satisfying the above conditions.
- the resin that can be used include other polyethylene resins, saturated or unsaturated polyester, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and mixtures thereof.
- the inner skin layer includes the same resin as the intermediate layer with which the inner skin layer contacts and the resin layer on the surface of the lid on the inner skin layer side, thereby enhancing the adhesion between these layers.
- the polyethylene-based resin is a resin containing a repeating unit of an ethylene group in a polymer main chain of 30 mol% or more, 40 mol% or more, 50 mol% or more, 60 mol% or more, 70 mol% or more, or 80 mol% or more.
- low density polyethylene LDPE
- linear low density polyethylene LLDPE
- medium density polyethylene MDPE
- high density polyethylene HDPE
- EAA ethylene-acrylic acid copolymer
- EAA ethylene-methacrylic Acid copolymer
- EAA ethylene-ethyl acrylate copolymer
- EMA ethylene-methyl acrylate copolymer
- EVA carboxylic acid modified polyethylene
- EVA carboxylic acid modified ethylene vinyl Acetate copolymer and Derivatives of al, as well as selected from the group consisting of mixtures.
- the thickness of the inner skin layer is preferably 5 ⁇ m or more, 10 ⁇ m or more, or 20 ⁇ m or more, and preferably 100 ⁇ m or less, 70 ⁇ m or less, 50 ⁇ m or less, or 40 ⁇ m or less.
- outer skin layer examples of the resin constituting the outer skin layer include polyethylene resins, polypropylene resins, saturated or unsaturated polyesters, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and mixtures thereof.
- PVC polyvinyl chloride
- the outer skin layer contains the same resin as the intermediate layer, thereby enhancing the adhesion with the intermediate layer.
- the thickness of the outer skin layer is preferably 5 ⁇ m or more, 10 ⁇ m or more, or 20 ⁇ m or more from the viewpoint of obtaining appropriate moldability and elasticity, and is preferably 100 ⁇ m or less, 70 ⁇ m or less, 50 ⁇ m or less, or 40 ⁇ m or less. .
- the intermediate layer In the intermediate layer, an inorganic absorbent is dispersed in a binder resin.
- the intermediate layer functions as an absorption layer that absorbs moisture and organic components in the blister pack.
- inorganic absorbents that can be used in the intermediate layer include chemical adsorbents such as calcium oxide, calcium chloride, calcium sulfate, magnesium sulfate, and sodium sulfate, and physical adsorbents such as aluminum oxide, quicklime, silica gel, and inorganic molecular sieves.
- inorganic molecular sieves include, but are not limited to, aluminosilicate minerals, clays, porous glass, microporous activated carbon, zeolite, activated carbon, or compounds having an open structure capable of diffusing small molecules such as water.
- Such an inorganic absorbent can obtain high hygroscopicity even in a low humidity region, and absorbs moisture slightly contained in the blister pack, even in such a low relative humidity environment. It is particularly preferable to use an absorbent that can exhibit high absorbability.
- Zeolite As the zeolite, natural zeolite, artificial zeolite, synthetic zeolite or the like can be used. Zeolite is a porous granular material used to separate substances according to the difference in molecular size, and has a structure with uniform pores. Therefore, water (steam, water vapor), organic gas, etc. can be absorbed.
- An example of a synthetic zeolite is a molecular sieve. Among these, a molecular sieve having a pore (absorption port) diameter of 0.3 nm to 1 nm can be used.
- molecular sieves having pore sizes of 0.3 nm, 0.4 nm, 0.5 nm, and 1 nm are referred to as molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, and molecular sieve 13X, respectively.
- the average particle size of the molecular sieve is, for example, about 10 ⁇ m. In the present invention, these zeolites can be properly used in accordance with the object to be absorbed and the properties of the contents.
- hydrophobic zeolite when absorbing odor, it is preferable to use hydrophobic zeolite because organic gas is often the causative substance.
- Hydrophobic zeolite is a generic term for a so-called high silica zeolite in which aluminum atoms in the crystal skeleton of the zeolite are reduced by dealumination to increase the silica-alumina ratio.
- Hydrophobic zeolite is a zeolite that loses its affinity for polar substances such as water and absorbs nonpolar substances more strongly, and more easily absorbs organic gases and the like.
- hydrophobic molecular sieve which is an example of the hydrophobic zeolite
- those having a pore diameter of 0.6 to 0.9 nm can be used, and examples thereof include Abscents 1000, Abscents 2000, Abscents 3000 (manufactured by Union Showa Co., Ltd.) and the like.
- the pore diameter can be confirmed by structural analysis by X-ray diffraction.
- the average particle size of the hydrophobic zeolite is, for example, 3 to 5 ⁇ m.
- the inorganic absorbent is 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more based on the weight of the intermediate layer. In the range of 90% by weight, 80% by weight, 70% by weight or less, or 60% by weight or less in the intermediate layer from the viewpoint of dispersibility in the binder resin and moldability. Can be included.
- the inorganic absorbent can be 5% by volume or more, 10% by volume or more, 20% by volume or more, or 30% by volume or more, 70.0% by volume or less, 65% by volume or less, 60% by volume or less, It can be 55 volume% or less, or 50 volume% or less.
- the specific gravity of the layer is obtained by measurement, the measured value, the inorganic absorbent and
- the volume% of the inorganic absorbent may be determined from the added weight of the thermoplastic resin and the specific gravity of the thermoplastic resin. For example, when the specific gravity of a layer formed using 50 g of an inorganic absorbent and 50 g of a thermoplastic resin having a specific gravity of 0.9 g / cm 3 is 1.1 g / cm 3 , it is included in the layer.
- the inorganic absorbent can be calculated to have a specific gravity of 1.41 g / cm 3, and it can be said that 38.9% by volume is present in the layer.
- the inorganic absorbent may be contained in the inner skin layer and / or the outer skin layer, but considering the moldability of these layers and the ease of bonding with other layers, etc., it is 40% by volume or less. 30 volume% or less, 28.8 volume% or less, 20 volume% or less, 10 volume% or less, or 5 volume% or less.
- binder resin examples include polyethylene resins, polypropylene resins, saturated or unsaturated polyesters, ionomers, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and mixtures thereof.
- the thickness of the intermediate layer is preferably 20 ⁇ m or more, 30 ⁇ m or more, or 40 ⁇ m or more from the viewpoint of absorption capacity, moldability, and elasticity, and is 500 ⁇ m or less, 300 ⁇ m or less, 200 ⁇ m or less, 150 ⁇ m or less, or 100 ⁇ m or less. It is preferable.
- the laminated body for blister packs of this invention has said base material layer by the side of the outer skin layer of said absorption layer and said absorption layer.
- the laminated body for blister packs of this invention has an aluminum layer between an absorption layer and a base material layer.
- the laminate 10 for blister packs of the present invention has a base material layer 2, an aluminum layer 3, and an absorption layer 4.
- a known laminating method such as dry lamination or extrusion lamination can be used.
- the resin used for the base material layer is not particularly limited as long as it provides a suitable moldability to the blister pack laminate.
- polypropylene resins, polyamides, and polyethylene terephthalate are particularly preferable.
- the thickness of the base material layer is preferably 10 ⁇ m or more, 20 ⁇ m or more, or 30 ⁇ m or more, and preferably 300 ⁇ m or less, 200 ⁇ m or less, or 100 ⁇ m or less.
- the aluminum layer is used for imparting barrier properties. This may be a pure aluminum-based aluminum foil or an aluminum alloy-based aluminum foil.
- the thickness of the aluminum layer is preferably 7 ⁇ m or more, 10 ⁇ m or more, or 20 ⁇ m or more, and 60 ⁇ m or less, 50 ⁇ m or less, or 40 ⁇ m or less in order to give appropriate moldability and elasticity to the blister pack laminate.
- a reinforcement layer is used in order to improve the moldability of the laminated body for blister packs.
- This may consist of polyvinyl chloride, saturated or unsaturated polyesters (eg polyethylene terephthalate, polybutylene terephthalate), polyamides and mixtures thereof.
- the thickness of the reinforcing layer is preferably 15 ⁇ m or more, or 25 ⁇ m or more, and is 60 ⁇ m or less, or 50 ⁇ m or less.
- the reinforcing layer described in Patent Document 3 can be used as the reinforcing layer.
- the laminated body for blister packs of the present invention includes a printed layer, an anchor coat layer for enhancing adhesion between two layers, a primer layer, between any two layers of a base material layer, an aluminum layer, a reinforcing layer, and an absorbent layer. You may have.
- the blister pack of this invention has said laminated body for blister packs, and a cover material.
- the laminate and the lid material are at least partially adhered, and in particular, when the two outermost layers of the above-described blister pack laminate are the inner skin layer of the base material layer and the absorbent layer, the lid material is the inner skin layer.
- Glue. Blister pack that contains the contents in the pocket part of the blister pack by forming the pocket part for storing the contents in the blister pack laminate and then storing the contents in the pocket part and bonding the lid material A package can be produced.
- the lid member includes a resin layer, and further includes an aluminum layer different from the aluminum layer that may be included in the above-described blister pack laminate.
- “another aluminum layer” may be the same material and thickness, that is, the same aluminum layer may be present in each of the blister pack laminate and the lid. is doing.
- the resin of the resin layer is selected from the group consisting of polypropylene resin, polyvinyl chloride, ethylene vinyl acetate copolymer, and mixtures thereof.
- the lid member has a form in which an aluminum layer is coated with a resin layer.
- the resin layer of the lid member and the layer (inner skin layer) to which the laminated body for blister packs adheres contain the same resin from the viewpoint of enhancing the adhesiveness.
- the contents of the blister pack of the present invention are not limited as long as they can be deteriorated by contact with the outside air, and examples thereof include drugs, foods, cosmetics, medical devices, electronic parts and the like. Moreover, as a chemical
- FIG. 1 is a schematic view of a blister pack 1 with an absorbent layer.
- a lid material 5 is bonded to a blister pack laminate 10 in which a base material layer 2, an aluminum layer 3, and an absorbent layer 4 are laminated in order, and a dome-shaped pocket formed in the laminate 10
- the content 100 is included in the part.
- the layers are laminated by a dry lamination method, there are adhesive layers between the base material layer and the aluminum layer and between the aluminum layer and the absorption layer.
- FIG. 2 is a schematic diagram of the layer structure of the blister pack of the present invention.
- the end portion of the blister pack where the pocket portion is not formed is shown.
- the blister pack laminate 10 in which the base material layer 2, the aluminum layer 3, and the absorbent layer 4 are laminated in this order.
- the lid 5 is adhered.
- the absorbent layer 4 includes an outer skin layer 41, an intermediate layer 42, and an inner skin layer 43, and the lid member includes a resin layer 51 and an aluminum layer 52.
- the laminate 10 is formed with a pocket portion for accommodating the contents.
- Example creation> The laminated bodies for blister packs of Examples 1 to 4 and Comparative Examples 1 to 5 were changed to only the configuration of the inner skin layer, and were configured as shown in Table 1 and Table 2 below.
- the material of each layer is put into a twin-screw kneading extruder (PCM-30 manufactured by Ikekai Co., Ltd.), kneaded while heating and melting the resin, and then extruded into a pellet to cool.
- the outer skin layer pellet, the intermediate layer pellet, and the inner skin layer pellet were obtained.
- a film serving as an absorption layer was formed by coextrusion molding using an inflation molding method. Inflation molding was performed with a three-layer inflation molding machine (3SOIB, Placo Corporation) at a resin temperature of 180 ° C. and a take-up speed of 13 m / min.
- the base layer, the aluminum layer, the reinforcing layer, and the outer skin layer of the absorption layer were all laminated by a dry lamination method.
- a urethane-based adhesive Takelac TM and Takenate TM
- the coating amount of the adhesive between each layer was 5 g / m 2 .
- ⁇ Evaluation 1 Surface roughness> The surface roughness (arithmetic mean roughness Ra) of the surface on the side opposite to the intermediate layer of the inner skin layer of the laminate for blister packs of Examples 1 to 4 and Comparative Examples 1 to 5 was determined according to ISO 4287. Measurement was performed using a thickness measuring machine (ET4000AK, Kosaka Laboratory Ltd.). An R2 ⁇ m needle tip, apex angle of 60 °, and a diamond stylus were used. The results for the arithmetic average roughness Ra of the inner skin layer are shown in FIG.
- the surface roughness is large and the slip property is high when HDPE is contained in less than 75 parts by weight.
- the surface roughness is low and the slipperiness is also low.
- this is considered to be because HDPE has a high density and therefore has low compatibility with PP, and when these are blended, a sea island structure is formed and the surface is roughened.
- the maximum indentation depth that can be formed was evaluated.
- the test is performed 10 times for each depth of each example, and when the appearance is not visually observed such as cracks, scratches, dents, etc. in the pockets formed by all 10 times, the conditions under which molding is possible It was.
- the test results are shown in FIG.
- the laminate (Comparative Example 1) including a conventional LLDPE 100% inner skin layer has a low maximum indentation depth of 4.75 mm.
- produced in the shoulder part of the dome shape of a pocket and the maximum indentation depth became 4.75 mm.
- the thickness of the top surface portion is not thin, it is considered that the plug and the surface of the laminate are not slipped at the time of molding, and an excessive load is applied to the shoulder portion.
- the laminate including the inner skin layers of Examples 1 to 4 having high slip properties the maximum indentation depth was 5.50 mm or more.
- the laminated body (comparative example 5) containing PP100% of inner skin layers was favorable in slip property, the moldability was as low as 5.00 mm. This is presumably because the elastic modulus of PP is lower than that of HDPE, and the force that stretches the inner skin layer during molding is transmitted non-uniformly to the aluminum layer, resulting in molding defects such as cracks.
- the laminated body for blister packs using the absorbent layer of the present invention deep pockets can be formed, and the blister packs using the same are stable for a long period of time (inhibition of alteration). Can be stored at.
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Food Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Composite Materials (AREA)
- Packages (AREA)
- Laminated Bodies (AREA)
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2017119533A (ja) * | 2015-12-28 | 2017-07-06 | 共同印刷株式会社 | ブリスターパック用積層体、及びそれを用いたブリスターパック |
JP2017214143A (ja) * | 2016-05-31 | 2017-12-07 | 共同印刷株式会社 | ブリスターパック用積層体、及びそれを用いたブリスターパック |
CN113518710A (zh) * | 2019-03-28 | 2021-10-19 | 积水化成品工业株式会社 | 层叠发泡片 |
WO2022097658A1 (ja) * | 2020-11-06 | 2022-05-12 | 出光ユニテック株式会社 | 積層体および容器 |
WO2024043910A1 (en) * | 2022-08-26 | 2024-02-29 | Zeus Company Inc. | Uhmwpe dip-coated tubes |
Families Citing this family (1)
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JP7351777B2 (ja) * | 2020-03-16 | 2023-09-27 | 株式会社Uacj製箔 | アルミニウム積層体、包装材、及びプレススルーパッケージ |
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- 2015-06-18 TW TW104119800A patent/TW201615517A/zh unknown
- 2015-06-18 WO PCT/JP2015/067659 patent/WO2015194645A1/ja active Application Filing
- 2015-06-18 JP JP2016529526A patent/JPWO2015194645A1/ja active Pending
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JPS61190460A (ja) * | 1985-02-06 | 1986-08-25 | 出光石油化学株式会社 | ブリスタ−包装体 |
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JP2004224430A (ja) * | 2003-01-27 | 2004-08-12 | Sumitomo Bakelite Co Ltd | Ptp包装用シート |
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JP2017119533A (ja) * | 2015-12-28 | 2017-07-06 | 共同印刷株式会社 | ブリスターパック用積層体、及びそれを用いたブリスターパック |
JP2017214143A (ja) * | 2016-05-31 | 2017-12-07 | 共同印刷株式会社 | ブリスターパック用積層体、及びそれを用いたブリスターパック |
CN113518710A (zh) * | 2019-03-28 | 2021-10-19 | 积水化成品工业株式会社 | 层叠发泡片 |
WO2022097658A1 (ja) * | 2020-11-06 | 2022-05-12 | 出光ユニテック株式会社 | 積層体および容器 |
WO2024043910A1 (en) * | 2022-08-26 | 2024-02-29 | Zeus Company Inc. | Uhmwpe dip-coated tubes |
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