WO2015169248A1 - 反应杯加载装置和化学发光免疫分析设备 - Google Patents

反应杯加载装置和化学发光免疫分析设备 Download PDF

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Publication number
WO2015169248A1
WO2015169248A1 PCT/CN2015/078515 CN2015078515W WO2015169248A1 WO 2015169248 A1 WO2015169248 A1 WO 2015169248A1 CN 2015078515 W CN2015078515 W CN 2015078515W WO 2015169248 A1 WO2015169248 A1 WO 2015169248A1
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WO
WIPO (PCT)
Prior art keywords
cuvette
transmission mechanism
push
push rod
cup
Prior art date
Application number
PCT/CN2015/078515
Other languages
English (en)
French (fr)
Inventor
饶微
班定平
易万贯
朱亮
胡毅
陈晓涛
尹力
林伟
Original Assignee
深圳市新产业生物医学工程股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深圳市新产业生物医学工程股份有限公司 filed Critical 深圳市新产业生物医学工程股份有限公司
Priority to EP15789287.8A priority Critical patent/EP3141910A4/en
Priority to US15/122,893 priority patent/US10139397B2/en
Publication of WO2015169248A1 publication Critical patent/WO2015169248A1/zh

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G01N33/5304—Reaction vessels, e.g. agglutination plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0465—Loading or unloading the conveyor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0467—Switching points ("aiguillages")
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0482—Transmission
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0482—Transmission
    • G01N2035/0484—Belt or chain

Definitions

  • the present invention relates to an in vitro diagnostic device, and more particularly to a cuvette loading device and a chemiluminescent immunoassay device using the cuvette loading device.
  • Biochemiluminescence immunoassay is a kind of flying radiolabeled immunoassay based on the theory of radioimmunoassay technology. It is a high-sensitivity, wide-ranging range and easy to operate. Easy to achieve automation and other advantages.
  • biochemical luminescence measuring instruments based on biochemiluminescence immunoassay have become mature medical diagnostic equipment.
  • general-purpose bioluminescence measuring instruments are expensive, bulky, and power-hungry, and are difficult to popularize and promote. With the rapid development of biomedical equipment, the full automation of biochemical luminescence measuring instruments has certain conditions.
  • the fully automatic chemiluminescence immunoassay analyzer mainly includes a cuvette feed system, a sample loading system, a luminescence detection system, a control system and a software system.
  • the cuvette feed system includes a cuvette supply and a reaction cup movement device. There are two main types of such devices: the first one is by grasping, and the second type is directly pushed from the end of the reaction cup.
  • the existing cuvette loading device is mainly composed of a transmission mechanism and a pushing mechanism.
  • the bottom plate of the transmission mechanism is provided with two convex parallel timing belts, and the timing belt transmits the reaction cup to the push cup to realize automatic supply of the reaction cup;
  • the push mechanism pushes the cuvette at the push cup to the next station through the end of the push rod.
  • a cuvette loading device comprising:
  • a transmission mechanism including a bottom plate and a first horizontal transmission mechanism disposed on the bottom plate;
  • Push institutions including:
  • a push rod disposed on the bracket assembly and coupled to the second horizontal transmission mechanism
  • a guiding control block comprising: a starting end provided at an end point of the push cup stroke of the push rod, a terminating end provided at a starting point of the push cup stroke of the push rod, and being disposed between the starting end and the ending end, and winding
  • the return path of the push cup stroke is opened, and the distance between the start end and the end end is one cup or more and two cup positions or less.
  • a chemiluminescent immunoassay device comprising a cuvette loading device as described above.
  • the embodiment of the invention controls the push rod to return from the upper part of the reaction cup after the pushing cup operation by setting the guiding control block, thereby greatly reducing the moving range of the putting rod, reducing the movement time of the putting rod, and reducing the product. volume.
  • Figure 1 is a schematic view showing the entire structure of a first embodiment of a cuvette loading device.
  • Figure 2 is a schematic view showing another overall structure of the first embodiment of the cuvette loading device.
  • Figure 3 is a front elevational view of the first embodiment of the cuvette loading device.
  • Figure 4 is a top plan view of a first embodiment of a cuvette loading device.
  • Figure 5 is a perspective view showing the structure of the steering control block in the first embodiment of the cuvette loading device.
  • Figure 6 is a front elevational view of the bottom plate of the second embodiment of the cuvette loading device.
  • Figure 7 is a schematic cross-sectional view taken along line A-A of Figure 6.
  • Figure 8 is a perspective view showing the structure of the cuvette of the cuvette in the third embodiment of the cuvette loading device.
  • Fig. 9 is a block diagram showing the configuration of a chemiluminescence immunoassay apparatus of an embodiment.
  • the embodiment mainly includes a transmission mechanism 1 and a pushing mechanism 2, wherein the transmission mechanism 1 includes: a bottom plate 11; a first horizontal transmission mechanism 12 disposed on the bottom plate 11; a transmission slot 13 disposed on the bottom plate 11 for receiving the first horizontal transmission mechanism 12; the pushing mechanism 2 includes: a bracket a second horizontal transmission mechanism 22 disposed on the bracket assembly 21; a push rod 23 disposed on the bracket assembly 21 and connected to the second horizontal transmission mechanism 22; vertically disposed on the bracket assembly 21 a vertical transmission mechanism 24 connected to the push rod 23 and the second horizontal transmission mechanism 22; and a guiding control block 25 disposed along the pusher stroke of the push rod, the guiding control block 25 is provided at the a starting end of the end of the push cup stroke of the push rod, a terminating end of the starting point of the push cup stroke of the push rod, and a return path disposed between the start end and the end end
  • the spacing between the starting end and the ending end can be set to be more than one cup position, two cups or less, specifically slightly larger than one cup position, leaving the action space for the push rod 23 to rise. .
  • the guidance control block 25 of the present embodiment will be described in detail below.
  • the return path can be set to include a lifting track with an ascending motion guiding surface 251 and a descending motion guiding surface 253.
  • the lifting rail further includes a horizontal motion guiding surface disposed between the rising motion guiding surface 251 and the descending motion guiding surface 253.
  • the back stroke is considered to be increased; the ascending motion guiding surface 251 may be provided as a smooth bevel; and the descending motion guiding surface 253 may be located at the Replace the landing port above the starting point of the push cup stroke.
  • the guiding control block 25 may further include a guiding base 254 including a mounting bottom plate and a mounting side plate extending upward from the rear side of the mounting base.
  • the horizontal motion guiding surface 252 is disposed at an intermediate position on the mounting side plate in parallel with the mounting bottom plate, and the falling opening 253 is coupled to the terminating end of the horizontal motion guiding surface 252, and the rising motion guiding surface
  • the top end of the 251 is smoothly connected to the starting end of the horizontal movement guiding surface 252, and the bottom end is connected to the mounting bottom plate.
  • a guide pin 231 coupled with the guiding control block 25 may be disposed on the push rod 23, and the guiding pin 231 is slidably It is worn in the guiding control block 25.
  • the structure of the lifting rail can be set to other structures according to specific needs, for example, the rising motion guiding surface and the descending motion guiding surface can be directly connected to form an arc or an arch. Smoothing the surface, the push rod along the smooth surface uphill and downhill, can also achieve the purpose of circling the push cup from the end point back to the starting point.
  • the structure of other returning tracks that are easy to think based on this purpose should also be It is included in the scope of protection of the present invention.
  • the first horizontal transmission mechanism 12 in this embodiment will be described in detail below.
  • the first horizontal transmission mechanism 12 may specifically include: a transmission motor 121 fixed to the rear end of the bottom plate 11; and two first timing belt driving wheels respectively axially connected to the two ends of the transmission motor 121 122; two first timing belt driven wheels 124 respectively disposed at the front ends of the two transmission slots 13 and respectively connected to the first timing belt driving wheels 122 through two first timing belts 123; a rotating shaft 125 axially connected to the two first timing belt driven wheels 124; a first horizontal linear guide 17 disposed on the bottom plate 11 and parallel to the first transmission slot 13; in this embodiment, In the case where the setting direction is stably transmitted to the cuvette, the first horizontal linear guide 17 may not be provided.
  • the bracket assembly 21 in this embodiment will be described in detail below.
  • the bracket assembly 21 may specifically include: a support post 210 extending upward from a rear end of the bottom plate 11; a horizontal mounting surface 211 disposed above the support post 210 and extending upward from a rear side of the horizontal mounting surface 211 a vertical mounting surface 212 is disposed on the front side of the vertical mounting surface 212 and connected to the second horizontal transmission mechanism 22 via a connecting block buckle 213 for fixing the connecting block 214 of the push rod 23
  • the second horizontal transmission mechanism 22 in this embodiment will be described in detail below.
  • the second horizontal transmission mechanism 22 may specifically include: a pusher motor 221 fixed to a rear side of one end of the vertical mounting surface 212; and a second timing belt axially connected to the pusher motor 221 a driving wheel 222; a second timing belt driven wheel 224 connected to the second timing belt driving wheel 222 via a second timing belt 223; a second timing belt 211 disposed on the horizontal mounting surface 211 and parallel to the second timing belt 223 Two horizontal linear guides 225.
  • the vertical transmission mechanism 24 in this embodiment will be described in detail below.
  • the vertical transmission mechanism 24 may specifically include: a vertical linear guide 241 vertically disposed on the bracket assembly and rigidly connected to the push rod and the second horizontal transmission mechanism; and vertical setting An elastic connector 242 between the push rod and the bracket assembly.
  • the push rod 23 and the vertical linear guide 241 are both disposed on the connecting block 214 of the bracket assembly 21, and the elastic connecting member 242 is disposed at the top end of the connecting block 214 and the push rod. Between the top ends of the 23, the connecting block 214 is connected to the second horizontal linear guide 225 by a connecting block snap 213.
  • the transmission motor 121 rotates to drive the first timing belt 123 located in the transmission groove 13 to advance, and the reaction cup placed on the bottom plate 11 is sent to the push cup 100, and the reaction cup is positive in the reaction cup baffle 10.
  • the stop 101 blocks the stop, and at the push cup 100 waits for the pusher 23 to push it to the next station.
  • the push motor 221 rotates, and the horizontal linear guide 225 is driven to move horizontally by the second timing belt 223, and the push rod 23 is driven to push the reaction cup to the next station; during the return stroke, the guide control block 25 is engaged with the guide pin 231 to push The rod 23 moves up and down while horizontally moving, bypassing the push cup stroke.
  • the push rod 23 stops the lifting movement, and at this time, the push rod 23 is higher than the upper surface of the reaction cup, and under the guiding action of the horizontal movement guiding surface 252, the push rod 23 only moves horizontally, from The reaction cup moves to the end of the reaction cup, thereby avoiding the reaction cup of the push cup 100.
  • the guide pin 231 is separated from the drop port 253 by the guiding action of the guiding control block 25, and the push rod 23 is lowered and pushed.
  • the reaction cup starts a new round of pushing the cup to achieve the purpose of loading the reaction cup.
  • the guiding control block is set along the starting point and the ending point of the push cup stroke of the push rod, and the push rod is controlled to return to the returning track after the pushing cup movement, and the pushing cup stroke (ie, the cup position of the reaction cup) is returned, thereby greatly reducing
  • the smaller range of the push rod reduces the movement time of the putter, which reduces the volume of the product and increases the working speed.
  • the second embodiment provided by the present invention will be described in detail below with reference to Figs. 1 to 4, Fig. 6, and Fig. 7.
  • the core of the embodiment is that, based on the foregoing first embodiment, the structure of the bottom plate 11 is improved. Specifically, two of the bottom plates 11 are provided in parallel for accommodating the first level. a transmission slot 13 of the transmission mechanism 12, and each of the transmission slots 13 is inclined downwardly at a position corresponding to the push cup on the tail end of the bottom plate 11, that is, inclined away from the first horizontal transmission mechanism 12 to form a slope
  • the structure 130, the angle of inclination of the slope structure 130 relative to the first horizontal transmission mechanism 12 can be set to 2-5 degrees.
  • a left side plate 14 and a right side plate 15 are respectively extended upward on the left and right sides of the bottom plate 11, and the left side plate 14 and/or the right side plate 15 are further provided with an electrical connection to the control circuit.
  • the cuvette sensing element 16 can employ three optocoupler devices.
  • the transmission motor 121 rotates to drive the first timing belt 123 forward, and the reaction cup placed on the bottom plate 11 is sent to the push cup 100, and the reaction cup is stopped under the blocking surface 101 of the cuvette 10 At the push cup 100, the push rod 23 is waited for pushing it to the next station. Since the position of the drive groove 13 corresponding to the push cup 100 is a bevel structure, the first timing belt 123 at the position is lower than the surface of the bottom plate 11, Thereby, the scratching between the cuvette and the first timing belt 123 when the lateral movement of the cuvette is removed is eliminated, thereby avoiding the problem of the cuvette dumping caused thereby.
  • the push motor 221 rotates, and the horizontal linear guide 225 is driven to move horizontally by the second timing belt 223, and the push rod 23 is driven to push the reaction cup to the next station; during the return stroke, the guide control block 25 is engaged with the guide pin 231 to push The rod 23 performs the lifting movement while moving horizontally.
  • the pushing rod 23 stops the lifting movement.
  • the pushing rod 23 has been higher than the upper surface of the reaction cup, and the guiding action of the horizontal movement guiding surface 252 Next, the pusher 23 is only horizontally moved from above the reaction cup to the end of the reaction cup, thereby avoiding the reaction cup at the push cup 100.
  • the guide pin 231 is separated from the drop port 253 out of the guide control block.
  • the guiding action of 25, the push rod 23 is lowered, the reaction cup is pushed, and a new round of pushing the cup is started to achieve the purpose of loading the reaction cup.
  • the driving groove corresponding to the position of the pushing cup on the bottom plate is set as the inclined surface structure, so that the first timing belt position at the position is lower than the surface of the bottom plate, thereby avoiding the scratching between the reaction cup and the timing belt when the reaction cup is laterally moved.
  • a third embodiment provided by the present invention will be described in detail below with reference to Figs. 1 to 4 and Fig. 8.
  • the core of the embodiment is that, based on the foregoing first embodiment, the structure of the cuvette flap 10 is improved, specifically: the cuvette flap 10 includes a positive stop surface 101, and from the front stop surface The upper end surface 102 of the top end of 101 extends forward.
  • the upper block surface 102 may be provided with a push rod groove 103 through which the push rod 23 passes.
  • the left end of the push rod groove 103 is a closed structure, and the right end is an open structure.
  • the transmission motor 121 rotates to drive the first timing belt 123 forward, and the reaction cup placed on the bottom plate 11 is sent to the push cup 100, and the reaction cup is stopped under the blocking surface 101 of the cuvette 10
  • the pusher 23 is waited for pushing it to the next station, while the upper face 102 of the cuvette flap 101 limits the upward movement of the cuvette to prevent bounce when the cuvette moves.
  • the push motor 221 rotates, and the horizontal linear guide 225 is driven to move horizontally by the second timing belt 223, and the push rod 23 is driven to push the reaction cup to the next station; during the return stroke, the guide control block 25 is engaged with the guide pin 231 to push The rod 23 performs the lifting movement while moving horizontally.
  • the pushing rod 23 stops the lifting movement.
  • the pushing rod 23 has been higher than the upper surface of the reaction cup, and the guiding action of the horizontal movement guiding surface 252 Next, the pusher 23 is only horizontally moved from above the reaction cup to the end of the reaction cup, thereby avoiding the reaction cup at the push cup 100.
  • the guide pin 231 is separated from the drop port 253 out of the guide control block.
  • the guiding action of 25, the push rod 23 is lowered, the reaction cup is pushed, and a new round of pushing the cup is started to achieve the purpose of loading the reaction cup.
  • the movement direction of the cuvette is guided and controlled, thereby effectively preventing the phenomenon of bounce when the cuvette moves, and correspondingly eliminating the resulting
  • the failure caused by the card cup problem improves the reliability of the product.
  • a fourth embodiment provided by the present invention will be described in detail below with reference to Figs.
  • the core of the embodiment is that, on the basis of the foregoing third embodiment, the structure of the cuvette baffle 10 is improved, and the improvement thereof is the same as the improvement of the cuvette baffle in the foregoing fourth embodiment, no longer One by one.
  • the transmission motor 121 rotates to drive the first timing belt 123 forward, and the reaction cup placed on the bottom plate 11 is sent to the push cup 100, and the reaction cup is stopped under the blocking surface 101 of the cuvette 10
  • the push rod 23 is waited for pushing it to the next station. Since the position of the drive groove 13 corresponding to the push cup 100 is a bevel structure, the first timing belt 123 at the position is lower than the surface of the bottom plate 11, Thereby eliminating the lateral direction of the cuvette The sliding between the first timing belt 123 and the first timing belt 123 avoids the resulting cuvette dumping problem; at the same time, the upper surface 102 of the cuvette plate 101 restricts the upward movement of the cuvette and prevents the reaction cup from moving. beat.
  • the push motor 221 rotates, and the horizontal linear guide 225 is driven to move horizontally by the second timing belt 223, and the push rod 23 is driven to push the reaction cup to the next station; during the return stroke, the guide control block 25 is engaged with the guide pin 231 to push The rod 23 performs the lifting movement while moving horizontally.
  • the pushing rod 23 stops the lifting movement.
  • the pushing rod 23 has been higher than the upper surface of the reaction cup, and the guiding action of the horizontal movement guiding surface 252 Next, the pusher 23 is only horizontally moved from above the reaction cup to the end of the reaction cup, thereby avoiding the reaction cup at the push cup 100.
  • the guide pin 231 is separated from the drop port 253 out of the guide control block.
  • the guiding action of 25, the push rod 23 is lowered, the reaction cup is pushed, and a new round of pushing the cup is started to achieve the purpose of loading the reaction cup.
  • this embodiment has at least the following advantages:
  • the guiding control block is arranged to control the push rod to bypass the cup position of the reaction cup along the return path after the pushing operation, thereby greatly reducing the moving range of the putting rod, reducing the movement time of the putting rod, and reducing the product. Volume, which increases the speed of work;
  • the transmission groove on the bottom plate corresponding to the position of the push cup is set as a bevel structure, so that the first timing belt at the position is lower than the surface of the bottom plate, thereby eliminating the scratching between the reaction belt and the first timing belt when the lateral movement of the reaction cup is avoided, thereby avoiding The resulting cuvette dumping problem;
  • An upper surface is added to the top end of the cuvette baffle to guide and control the movement direction of the cuvette, thereby effectively preventing the phenomenon of bounce when the cuvette moves, and correspondingly eliminating the problem of the cup cup caused thereby.
  • the failure has improved the reliability of the product.
  • an embodiment also discloses a chemiluminescence immunoassay device 300, including a cuvette feed system 301, a sample loading system 302, a luminescence detection system 303, and a control system 304, wherein the cuvette
  • the feed system 301 can employ any of the cuvette loading devices described in the foregoing embodiments, and the same points will not be repeated.

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Abstract

一种反应杯加载装置和全自动化学发光免疫分析设备，所述反应杯加载装置包括有传动机构（1）和推送机构（2），所述传动机构（1）包括有底板（11）和设于所述底板（11）上的第一水平传动机构（12），所述推送机构（2）包括有支架组件（21）、设于所述支架组件（21）上的第二水平传动机构（22）、和与所述第二水平传动机构（22）连接的推杆（23），所述推送机构（2）还包括有：导向控制块（25），该导向控制块（25）包括有设于所述推杆（23）的推杯行程终点的起始端、设于所述推杆（23）的推杯行程起点的终止端、和设于所述起始端和终止端之间，并绕开所述推杯行程的回程轨道，且所述起始端和终止端之间的间距为一个杯位以上、两个杯位以下。

Description

反应杯加载装置和化学发光免疫分析设备
【技术领域】
本发明涉及一种体外诊断设备，尤其涉及一种反应杯加载装置和采用该反应杯加载装置的化学发光免疫分析设备。
【背景技术】
生物化学发光免疫分析法是建立在放射免疫分析技术的理论基础上，以标记法光机为示踪信号建立起来的一种飞放射标记免疫分析法，具有灵敏度高、限行范围宽、易操作、易于实现自动化等优点。目前，基于生物化学发光免疫分析法的生化发光测量仪已经成为成熟的医疗诊断设备。然而，通用型生化发光测量仪设备价格昂贵、体积笨重、功耗巨大，难以普及和推广。而随着生物医药设备的高速发展，实现生化发光测量仪的全自动化具备了一定的条件。
全自动化学发光免疫分析仪主要包括反应杯进给系统、加样系统、发光检测系统、控制系统以及软件系统。其中，反应杯进给系统中包括反应杯供给及反应杯移动的装置，现有的此类装置主要有两种：第一种通过抓取，第二种是从反应杯端部直接推动。
现有的反应杯加载装置主要由传动机构和推送机构构成，传动机构底板上设置有两条凸起的平行同步带，同步带将反应杯传送至推杯处，实现反应杯的自动供给；而推送机构通过推杆的端部将推杯处的反应杯推送到下一工位。
然而，发明人在实际使用的过程中发现，现有技术的反应杯加载装置具有以下缺点：推杆在推动反应杯时，为了避开推杯处的反应杯，推杆的运动范围至少需要占用两个杯位的空间，导致产品的整体体积大，占用空间多。
【发明内容】
有鉴于此，有必要提供一种可减小产品体积的反应杯加载装置。
一种反应杯加载装置，包括：
传动机构，包括底板和设于该底板上的第一水平传动机构；以及
推送机构，包括：
支架组件；
设于该支架组件上的第二水平传动机构；
设于所述支架组件上并与所述第二水平传动机构连接的推杆；以及
导向控制块，包括设于所述推杆的推杯行程终点的起始端、设于所述推杆的推杯行程起点的终止端、和设于所述起始端和终止端之间，并绕开所述推杯行程的回程轨道，且所述起始端和终止端之间的间距为一个杯位以上、两个杯位以下。
一种化学发光免疫分析设备，包括如上所述的反应杯加载装置。
本发明的实施例通过设置导向控制块，控制推杆在推杯动作后从反应杯的上方回位，从而大大减小了推杆的运动范围，缩小了推杆的运动时间，减小了产品体积。
【附图说明】
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他实施例的附图。
图1是反应杯加载装置第一实施例的整体结构示意图。
图2是反应杯加载装置第一实施例的另一整体结构示意图。
图3是反应杯加载装置第一实施例的主视图。
图4是反应杯加载装置第一实施例的俯视图。
图5是反应杯加载装置第一实施例中导向控制块的立体结构示意图。
图6是反应杯加载装置第二实施例中底板的主视图。
图7是沿图6中A-A线的剖面示意图。
图8是反应杯加载装置第三实施例中反应杯挡板的立体结构示意图。
图9是一实施方式的化学发光免疫分析设备的结构方框图。
【具体实施方式】
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
下面参考图1-5详细描述反应杯加载装置的一个实施例；如图1和图2所示，本实施例主要包括有传动机构1和推送机构2，其中，所述传动机构1包括有：底板11；设于该底板11上的第一水平传动机构12；设于该底板11上，用于容置所述第一水平传动机构12的传动槽13；所述推送机构2包括有：支架组件21；设于该支架组件21上的第二水平传动机构22；设于所述支架组件21上并与所述第二水平传动机构22连接的推杆23；竖直设置于该支架组件21上并与所述推杆23和第二水平传动机构22连接的竖直传动机构24；以及沿所述推杆的推杯行程设置的导向控制块25，该导向控制块25包括有设于所述推杆的推杯行程终点的起始端、设于所述推杆的推杯行程起点的终止端、和设于所述起始端和终止端之间，并绕开所述推杯行程的回程轨道。
在本实施例中，所述起始端和终止端之间的间距可设置成一个杯位以上、两个杯位以下，具体为略大于一个杯位，留出推杆23上升的动作空间即可。
下面详细描述本实施例的导向控制块25。
具体实现时，所述回程轨道可设置为包括有上升运动导向面251和下降运动导向面253的升降轨道。
进一步地，所述升降轨道还包括有设于所述上升运动导向面251和下降运动导向面253之间的水平运动导向面。
更进一步地，为了尽量减小推杆23回程过程中所受的阻力，加快其回程之间考虑；所述上升运动导向面251可设置为平滑斜面；而所述下降运动导向面253可由位于所述推杯行程起点上方的降落口代替。
更进一步地，为了合理地固定所述升降轨道考虑，导向控制块25还可包括有一导向底座254，该导向底座254包括有一安装底板和从该安装底板后侧向上延伸出的安装侧板，所述水平运动导向面252与所述安装底板平行地设于所述安装侧板上的中间位置，所述降落口253衔接于所述水平运动导向面252的终止端，而所述上升运动导向面251的顶端与所述水平运动导向面252的起始端平滑连接，底端与所述安装底板连接。
更进一步地，为了使导向控制块25能够更佳地引导推杆23回程考虑，在所述推杆23上还可设置与所述导向控制块25配合的导向销231，导向销231可滑动地穿设于导向控制块25中。
值得说明的是，所述升降轨道的结构除了以上方式外，还可根据具体需要设置成其他结构，如：可设置成上升运动导向面和下降运动导向面直接连接，形成弧形或拱形的平滑曲面，推杆沿平滑曲面上坡和下坡，也可以达到从终点绕开推杯行程回到起点的目的，基于这一目的而容易想到的根据常理设置的其他回程轨道的结构，也应包含在本发明的保护范围之内。
下面详细描述本实施例中的第一水平传动机构12。
具体实现时，所述第一水平传动机构12可具体包括有：固定于所述底板11尾端的传动电机121；与该传动电机121的两端分别轴向连接的两个第一同步带主动轮122；分别设于所述两个传动槽13的前端，并分别通过两条第一同步带123与所述第一同步带主动轮122连接的两个第一同步带从动轮124；与所述两个第一同步带从动轮124轴向连接的转轴125；设于所述底板11上，与所述第一传动槽13平行的第一水平直线导轨17；本实施例中，在能保证朝设定方向稳定地传输反应杯的情况下，也可以不需要设置所述第一水平直线导轨17。
下面详细描述本实施例中的支架组件21。
具体实现时，所述支架组件21可具体包括有：从所述底板11尾端向上延伸的支承柱210；设于支承柱210上方的水平安装面211和从该水平安装面211后侧向上延伸出的竖直安装面212；设于该竖直安装面212的前侧，并通过连接块卡扣213与所述第二水平传动机构22连接，用于固定所述推杆23的连接块214；下面详细描述本实施例中的第二水平传动机构22。
具体实现时，所述第二水平传动机构22可具体包括有：固定于所述竖直安装面212一端的后侧的推杯电机221；与该推杯电机221轴向连接的第二同步带主动轮222；通过第二同步带223与所述第二同步带主动轮222连接的第二同步带从动轮224；设于所述水平安装面211并与所述第二同步带223平行的第二水平直线导轨225。下面详细描述本实施例中的竖直传动机构24。
具体实现时，所述竖直传动机构24可具体包括有：竖直设于所述支架组件上并与所述推杆和第二水平传动机构刚性连接的竖直直线导轨241；和竖直设于所述推杆和所述支架组件之间的弹性连接件242。
更进一步地，所述推杆23和竖直直线导轨241均设置在所述支架组件21的连接块214上，所述弹性连接件242则设于所述连接块214的顶端与所述推杆23的顶端之间，且该连接块214通过连接块卡扣213与所述第二水平直线导轨225连接。
下面详细描述本实施例的工作原理。
工作时，传动电机121旋转，带动位于传动槽13内的第一同步带123向前推进，将置于底板11上的反应杯输送至推杯处100，反应杯在反应杯挡板10的正挡面101阻挡下停止，在推杯处100等待推杆23将其推到下一工位。
推送电机221旋转，通过第二同步带223驱动水平直线导轨225水平运动，带动推杆23将反应杯推出到下一工位；在回程时，导向控制块25通过与导向销231配合，使推杆23在水平运动的同时作升降运动，绕开推杯行程。到达上升运动导向面251最高处时，推杆23停止升降运动，此时推杆23已高于反应杯上表面，在水平运动导向面252的导向作用下，推杆23只作水平运动，从反应杯上方移动到反应杯末端，从而避开了推杯处100的反应杯，在反应杯的末端位置，导向销231从降落口253脱离导向控制块25的导向作用，推杆23下降，推动反应杯，开始新一轮的推杯动作，达到加载反应杯的目的。
本实施例通过沿推杆的推杯行程起点和终点设置导向控制块，控制推杆在推杯动作后沿回程轨道，绕开推杯行程（即反应杯的杯位）回位，从而大大减小了推杆的运动范围，缩小了推杆的运动时间，既减小了产品体积，又提高了工作速度。
下面参考图1-图4、图6和图7详细描述本发明提供的第二实施例。本实施例的核心在于，在前述第一实施例的基础上，对底板11的结构进行了改进，具体为：在所述底板11上平行地设有两条用于容置所述第一水平传动机构12的传动槽13，且每条传动槽13在对应所述底板11尾端上的推杯处位置向下倾斜设置，即朝远离第一水平传动机构12的方向倾斜，以形成一段斜面结构130，该斜面结构130相对于第一水平传动机构12的倾斜角度可设置为2-5度。
进一步地，在所述底板11的左右两侧还分别向上延伸出左侧板14和右侧板15，所述左侧板14和/或右侧板15上还设有电连接到控制电路的反应杯感应元件16，该反应杯感应元件16可采用三个光耦器件。
下面详细描述本实施例的工作原理。
工作时，传动电机121旋转，带动第一同步带123向前推进，将置于底板11上的反应杯输送至推杯处100，反应杯在反应杯挡板10的正挡面101阻挡下停止，在推杯处100等待推杆23将其推到下一工位，由于传动槽13对应推杯处100的位置为斜面结构，使得该处的第一同步带123位置低于底板11表面，从而消除了反应杯横向移动时与第一同步带123之间的刮碰，避免了因此而产生的反应杯倾倒问题。
推送电机221旋转，通过第二同步带223驱动水平直线导轨225水平运动，带动推杆23将反应杯推出到下一工位；在回程时，导向控制块25通过与导向销231配合，使推杆23在水平运动的同时作升降运动，到达升降运动导向面251最高处时，推杆23停止升降运动，此时推杆23已高于反应杯上表面，在水平运动导向面252的导向作用下，推杆23只作水平运动，从反应杯上方移动到反应杯末端，从而避开了推杯处100的反应杯，在反应杯的末端位置，导向销231从降落口253脱离导向控制块25的导向作用，推杆23下降，推动反应杯，开始新一轮的推杯动作，达到加载反应杯的目的。
本实施例通过将底板上对应推杯处位置的传动槽设置为斜面结构，使得该处的第一同步带位置低于底板表面，从而避免了反应杯横向移动时与同步带之间的刮碰，消除了因此而产生的反应杯倾倒问题，提高了产品的可靠性。
下面参考图1-图4、和图8详细描述本发明提供的第三实施例。本实施例的核心在于，在前述第一实施例的基础上，对反应杯挡板10的结构进行了改进，具体为：反应杯挡板10包括有正挡面101，以及从该正挡面101的顶端向前方延伸出的上挡面102。
具体实现时，所述上挡面102上可设有供推杆23穿过的推杆槽103，该推杆槽103的左端为封闭结构，右端为开口结构。
下面详细描述本实施例的工作原理。
工作时，传动电机121旋转，带动第一同步带123向前推进，将置于底板11上的反应杯输送至推杯处100，反应杯在反应杯挡板10的正挡面101阻挡下停止，在推杯处100等待推杆23将其推到下一工位，同时反应杯挡板101的上档面102限制了反应杯向上的运动，防止反应杯移动时产生跳动。
推送电机221旋转，通过第二同步带223驱动水平直线导轨225水平运动，带动推杆23将反应杯推出到下一工位；在回程时，导向控制块25通过与导向销231配合，使推杆23在水平运动的同时作升降运动，到达升降运动导向面251最高处时，推杆23停止升降运动，此时推杆23已高于反应杯上表面，在水平运动导向面252的导向作用下，推杆23只作水平运动，从反应杯上方移动到反应杯末端，从而避开了推杯处100的反应杯，在反应杯的末端位置，导向销231从降落口253脱离导向控制块25的导向作用，推杆23下降，推动反应杯，开始新一轮的推杯动作，达到加载反应杯的目的。
本实施例通过在反应杯挡板的顶端加设了上挡面，对反应杯的运动方向进行引导和控制，从而有效防止了反应杯移动时产生跳动的现象，相应地消除了因此而产生的卡杯问题导致的故障，提高了产品的可靠性。
下面参考图1-8详细描述本发明提供的第四实施例。本实施例的核心在于，在前述第三实施例的基础上，对反应杯挡板10的结构进行了改进，且其改进与前述第四实施例中对反应杯挡板的改进相同，不再一一赘述。
下面详细描述本实施例的工作原理。
工作时，传动电机121旋转，带动第一同步带123向前推进，将置于底板11上的反应杯输送至推杯处100，反应杯在反应杯挡板10的正挡面101阻挡下停止，在推杯处100等待推杆23将其推到下一工位，由于传动槽13对应推杯处100的位置为斜面结构，使得该处的第一同步带123位置低于底板11表面，从而消除了反应杯横向 移动时与第一同步带123之间的刮碰，避免了因此而产生的反应杯倾倒问题；同时反应杯挡板101的上档面102限制了反应杯向上的运动，防止反应杯移动时产生跳动。
推送电机221旋转，通过第二同步带223驱动水平直线导轨225水平运动，带动推杆23将反应杯推出到下一工位；在回程时，导向控制块25通过与导向销231配合，使推杆23在水平运动的同时作升降运动，到达升降运动导向面251最高处时，推杆23停止升降运动，此时推杆23已高于反应杯上表面，在水平运动导向面252的导向作用下，推杆23只作水平运动，从反应杯上方移动到反应杯末端，从而避开了推杯处100的反应杯，在反应杯的末端位置，导向销231从降落口253脱离导向控制块25的导向作用，推杆23下降，推动反应杯，开始新一轮的推杯动作，达到加载反应杯的目的。
与现有技术相比，本实施例至少具有以下优点：
设置了导向控制块，控制推杆在推杯动作后沿回程轨道绕开反应杯的杯位回程，从而大大减小了推杆的运动范围，缩小了推杆的运动时间，既减小了产品体积，又提高了工作速度；
将底板上对应推杯处位置的传动槽设置为斜面结构，使得该处的第一同步带位置低于底板表面，从而消除了反应杯横向移动时与第一同步带之间的刮碰，避免了因此而产生的反应杯倾倒问题；
在反应杯挡板的顶端加设了上挡面，对反应杯的运动方向进行引导和控制，从而有效防止了反应杯移动时产生跳动的现象，相应地消除了因此而产生的卡杯问题导致的故障，提高了产品的可靠性。
请参阅图9，一实施例中还公开了一种化学发光免疫分析设备300，包括有反应杯进给系统301、加样系统302、发光检测系统303、控制系统304，其中，所述反应杯进给系统301可采用前述各实施例所描述的任一种反应杯加载装置，相同之处，不再一一赘述。
上述说明已经充分揭露了本发明的具体实施方式。需要指出的是，熟悉该领域的技术人员对本发明的具体实施方式所做的任何改动均不脱离本发明的权利要求书的范围。相应地，本发明的权利要求的范围也并不仅仅局限于前述具体实施方式。

Claims (12)

  1. 一种反应杯加载装置，其特征在于，包括：
    传动机构，包括底板和设于该底板上的第一水平传动机构；以及
    推送机构，包括：
    支架组件；
    设于该支架组件上的第二水平传动机构；
    设于所述支架组件上并与所述第二水平传动机构连接的推杆；以及导向控制块，包括设于所述推杆的推杯行程终点的起始端、设于所述推杆的推杯行程起点的终止端、和设于所述起始端和终止端之间，并绕开所述推杯行程的回程轨道，且所述起始端和终止端之间的间距为一个杯位以上、两个杯位以下。
  2. 如权利要求1所述的反应杯加载装置，其特征在于，所述回程轨道包括上升运动导向面和下降运动导向面。
  3. 如权利要求2所述的反应杯加载装置，其特征在于，所述回程轨道还包括设于所述上升运动导向面和下降运动导向面之间的水平运动导向面。
  4. 如权利要求1所述的反应杯加载装置，其特征在于，所述回程轨道包括上升运动导向面、降落口，以及设于所述上升运动导向面和降落口之间的水平运动导向面，所述上升运动导向面为平滑斜面。
  5. 如权利要求4所述的反应杯加载装置，其特征在于，所述导向控制块还包括导向底座，该导向底座包括安装底板和从该安装底板后侧向上延伸出的安装侧板，所述水平运动导向面与所述安装底板平行地设于所述安装侧板上的中间位置，所述降落口衔接于所述水平运动导向面的终止端，而所述上升运动导向面的顶端与所述水平运动导向面的起始端平滑连接，底端与所述安装底板连接。
  6. 如权利要求1-5中任一项所述的反应杯加载装置，其特征在于，所述推送装置还包括：
    设于所述支架组件上，并与所述推杆和第二水平传动机构连接的竖直传动机构。
  7. 如权利要求1-5中任一项所述的反应杯加载装置，其特征在于，所述推杆上还设有导向销，所述导向销可滑动地穿设于所述导向控制块中。
  8. 如权利要求1-5中任一项所述的反应杯加载装置，其特征在于，在所述底板上平行地设有两条用于容置所述第一水平传动机构的传动槽，且每条传动槽在对应所述底板上的推杯处位置朝远离所述第一水平传动机构的方向倾斜，以形成斜面结构。
  9. 如权利要求8所述的反应杯加载装置，其特征在于，所述斜面结构相对于所述第一水平传动机构的倾斜角度为2-5度。
  10. 如权利要求1-5中任一项所述的反应杯加载装置，其特征在于，所述传动机构还包括设于所述导向控制块前下方的反应杯挡板，该反应杯挡板包括正挡面，以及从该正挡面的顶端向前方延伸出的上挡面。
  11. 如权利要求10所述的反应杯加载装置，其特征在于，所述上挡面上设有供推杆穿过的推杆槽，该推杆槽的左端为封闭结构，右端为开口结构。
  12. 一种化学发光免疫分析设备，包括如权利要求1-11中任一项所述的反应杯加载装置。
PCT/CN2015/078515 2014-05-08 2015-05-08 反应杯加载装置和化学发光免疫分析设备 WO2015169248A1 (zh)

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