WO2015156017A1 - Procédé permettant de favoriser la pénétration d'un ingrédient de soin de beauté dans la peau et dispositif permettant de favoriser la pénétration d'un ingrédient de soin de beauté dans la peau - Google Patents

Procédé permettant de favoriser la pénétration d'un ingrédient de soin de beauté dans la peau et dispositif permettant de favoriser la pénétration d'un ingrédient de soin de beauté dans la peau Download PDF

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Publication number
WO2015156017A1
WO2015156017A1 PCT/JP2015/052652 JP2015052652W WO2015156017A1 WO 2015156017 A1 WO2015156017 A1 WO 2015156017A1 JP 2015052652 W JP2015052652 W JP 2015052652W WO 2015156017 A1 WO2015156017 A1 WO 2015156017A1
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Prior art keywords
skin
penetration
ions
cosmetic
ion
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PCT/JP2015/052652
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English (en)
Japanese (ja)
Inventor
絵美 齋藤
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シャープ株式会社
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Publication date
Application filed by シャープ株式会社 filed Critical シャープ株式会社
Priority to CN201580008864.0A priority Critical patent/CN106061542A/zh
Priority to JP2016512614A priority patent/JPWO2015156017A1/ja
Publication of WO2015156017A1 publication Critical patent/WO2015156017A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Definitions

  • the present invention relates to a technique for promoting penetration of cosmetic ingredients contained in cosmetics and the like into the skin.
  • ionization is a method of penetrating a component ionized using a direct current to the back of the skin by energizing the skin.
  • Patent Document 1 proposes a method of increasing the penetration of ingredients into the skin by miniaturizing cosmetics using an ultrasonic element.
  • the above-described ion introduction has a high penetration effect, but a cosmetic ingredient that is weak against electrical stimulation is decomposed at the stage of ionization, and there is a problem that it is unclear whether it is penetrated while maintaining the efficacy of the ingredient. It was. Moreover, in order to acquire an effect, it was necessary to energize skin for about 5 minutes, and there also existed a difficulty that it took an effort.
  • the present invention has been made to solve the above-described problems, and an object of the present invention is to provide a method and an apparatus capable of penetrating cosmetic ingredients into the skin more easily than before.
  • the present invention promotes the penetration of the cosmetic ingredient into the skin by contacting the cosmetic ingredient with the skin and then irradiating the cosmetic ingredient with positive ions and negative ions combined with water molecules generated by discharge in the atmosphere. It is a method to do.
  • the present invention is also an apparatus used to promote the penetration of cosmetic ingredients into the skin, and an ion generator that generates positive ions and negative ions combined with water molecules generated by discharge in the atmosphere; Also provided is a cosmetic ingredient skin permeation promoting device comprising a blowing part for sending the positive ions and negative ions to the skin in contact with the cosmetic ingredient.
  • the positive ion is H + (H 2 O) m (m is an arbitrary natural number), and the negative ion is O 2 ⁇ (H 2 O) n (n is an arbitrary natural number). preferable.
  • the present invention it is possible to provide a method and an apparatus therefor, in which a cosmetic ingredient can penetrate deeper into the skin than before and a sufficient effect of the cosmetic ingredient can be obtained.
  • FIG. 1 It is a schematic diagram for demonstrating the principle of the ion generation using the ion generating element 60 in the apparatus used suitably for the method of accelerating
  • FIG. 1 It is a schematic diagram which shows the external appearance of the whole apparatus (Preferred example (Embodiment 1) of the skin penetration promotion apparatus of this invention) provided with the ion generating element 60 shown in FIG.
  • FIG. It is a figure which shows typically the external appearance of the skin penetration promotion apparatus 71 (Embodiment 2) of the other preferable example of this invention.
  • FIG. 2 It is a figure which shows typically the cross section of the skin penetration promotion apparatus 71 (Embodiment 2) of the other preferable example of this invention.
  • FIG. 8A is a photograph showing the results of Experimental Example 1
  • FIG. 8A shows Example 1
  • FIG. 8B shows Comparative Example 1
  • FIG. 8C shows Comparative Example 2.
  • FIG. 10 is a graph showing the results of Experimental Example 2.
  • the method of promoting the penetration of the cosmetic component of the present invention into the skin comprises contacting the cosmetic component with the skin, and then adding positive ions and negative ions combined with water molecules generated by discharge in the atmosphere to the cosmetic component. Irradiating.
  • the “beauty component” is a component having a hydrophilic group such as ceramide, collagen, hyaluronic acid, ascorbic acid, etc., and cosmetics such as lotion, cosmetic liquid, milky lotion, cream, quasi-drugs, pharmaceuticals This refers to natural or synthetic chemicals that are applied to the skin, such as the face, to make the appearance beautiful.
  • FIG. 1 shows an ion using an ion generating element 60 in an apparatus (a preferable example of the skin permeation promoting apparatus of the present invention described later) suitably used for the method of promoting the penetration of the cosmetic component of the present invention into the skin.
  • FIG. 2 is a schematic diagram for explaining the principle of generation, and FIG. 2 is an apparatus (preferred example of the skin permeation promoting apparatus of the present invention) including the ion generating element 60 shown in FIG. It is a schematic diagram shown.
  • the ion generating element 60 has an ion generating element 60 shown in FIG. 1 as an ion generating part in a case (housing).
  • the ion generating element 60 includes voltage application needle electrodes 1 and 2 connected to the high voltage generation devices 4 and 5 and a ground (opposite) electrode 3 disposed adjacent to the voltage application needle electrodes 1 and 2. .
  • the ground electrode 3 is provided with a number of through-holes 31 through which the voltage application needle electrodes 1 and 2 pass, in the number of voltage application needle electrodes.
  • the voltage application needle electrodes 1 and 2 have needle-shaped tips, and the voltage application needle electrodes 1 and 2 are connected to and supported by the high voltage generators 4 and 5, and the center of the through hole 31 of the ground electrode 3 is supported.
  • the needle tip is located in the through hole 31 within the thickness range of the ground electrode 3.
  • the high voltage generators 4 and 5 supply the DC pulse voltage to the voltage application needle electrodes 1 and 2 to discharge them, thereby ionizing the air in the vicinity of the ground electrode 3. Ions generated by the ion generating element 60 of the ion generator 6 are released from the opening 61 of the case. And the released ion is dissipated in the atmosphere by a blower fan 7 installed adjacent to the ion generator 6 as a blower.
  • the ion generating element 60 includes, as ion generating electrodes, a voltage applying needle electrode 1 (positive ion generating electrode) connected to the high voltage generating device 4 and a voltage applying needle electrode 2 (negative ion generating electrode) connected to the high voltage generating device 5. ).
  • a DC pulse voltage is supplied to the voltage application needle electrode 1 to apply a positive voltage
  • a DC pulse voltage is supplied to the voltage application needle electrode 2 to apply a negative voltage.
  • the amount (concentration) of ions to be generated is adjusted by the voltage / pulse period applied to the voltage application needle electrodes 1 and 2 by the high voltage generators 4 and 5.
  • the cosmetic ingredient is irradiated with positive ions and negative ions combined with water molecules generated by discharge in the atmosphere.
  • the cosmetic component can be efficiently penetrated into the skin.
  • the positive ion is H + (H 2 O) m (m is an arbitrary natural number)
  • the negative ion is O 2 ⁇ (H 2 O) n (n is an arbitrary natural number).
  • the concentration of positive ions and negative ions generated by discharge is preferably 7,000 / cm 3 or more, respectively. This is because when the concentration of positive ions and negative ions is less than 7,000 / cm 3 , the efficiency of the action of supplementing the skin with water tends to be low.
  • the definition of the number of ions is a value obtained by counting small ions, and the critical mobility in air is 1 cm 2 / V ⁇ sec.
  • the skin penetration of the cosmetic component is promoted by the present invention is that the water of positive and negative ions comes into contact with the skin and penetrates it, thereby forming a path for the cosmetic component having a hydrophilic group to penetrate. It is thought to be due to the mechanism.
  • the present invention also provides an apparatus suitably used in the above-described method for promoting skin penetration of a cosmetic ingredient of the present invention.
  • the cosmetic component skin permeation promoting device of the present invention is a positive ion and negative ion generating unit that binds to water molecules generated by discharge in the atmosphere, and the positive ion on the skin in which the cosmetic component is in contact. And a blower for sending negative ions. Specifically, it can be suitably realized with the configuration described above with reference to FIGS.
  • FIG. 3 and FIG. 4 are views schematically showing a skin penetration promoting device 71 (Embodiment 2) of another preferred example of the present invention, FIG. 3 shows an appearance, and FIG. 4 shows a cross section.
  • an ion generator 77 having an ion generator as shown in FIG. 1 is provided as an ion generator in a case (housing) 72 a. Ions generated by the ion generating element of the ion generating unit 77 are discharged from the opening (blow-out port) 76 of the case 72a.
  • FIG. 1 a skin penetration promoting device 71 of another preferred example of the present invention
  • FIG. 3 shows an appearance
  • FIG. 4 shows a cross section.
  • the skin penetration promoting device 71 includes a blower 75 having a blower fan 78 adjacent to the ion generator 77. Positive ions and negative ions generated in the ion generator 77 are dissipated into the atmosphere by the blower fan 78 of the blower 75.
  • the skin penetration promoting device 71 configured as described above is used during sleeping, for example, the skin can be irradiated with ions for a long time without trouble.
  • the skin penetration promoting device 71 has the ion generating part 77 and the air blowing part 75 arranged at a convenient position during sleep, and the casing 72a and the support part 74 are connected by an arm 73 that can freely adjust the inclination. It is preferable.
  • the skin permeation promoting device 71 preferably has a small amount of air blown by the blower fan 78 in order to prevent the skin from being dried while being used for a long time such as sleeping.
  • FIGS. 5 to 7 are diagrams schematically showing a skin penetration promoting device 120 (Embodiment 3) of another preferred example of the present invention.
  • FIG. 5 is an appearance of the front side
  • FIG. FIG. 7 is a vertical side view (excluding the clip portion).
  • the skin permeation promoting device 120 shown in FIGS. 5 to 7 also includes an ion generating unit that generates positive ions and negative ions combined with water molecules generated by discharge in the atmosphere, and the skin in contact with the cosmetic component. It has a blowing section for sending positive ions and negative ions, and has a function of blowing out positive ions and negative ions to the outside together with air sucked from the outside.
  • Skin permeation promoting device 120 has a prismatic outer shape, and is small, for example, having a height of about 50 mm, a width in the left-right direction of about 35 mm, and a thickness in the front-rear direction of about 10 mm, and can be used for portable use.
  • the skin penetration promoting device 120 includes a housing 121, a circuit board 163, a battery 164, a blower 165 that is the above-described blowing unit, an ion generator 166 that is the above-described ion generating unit, a clip unit 122, and a hanging strap 128.
  • the housing 121 includes a body 11 that is a vertical and rectangular tube, a plate-shaped upper plate 132 that covers the upper end of the body 131, and a plate-shaped bottom plate 133 that covers the lower end of the body 131.
  • the body part 131 has a suction port 131a slightly in the middle of the left and right sides.
  • the upper plate 132 has air outlets 132a and 132b on the front side.
  • the bottom plate 133 is provided with a USB socket terminal and a power button (not shown) for connection to an external power source.
  • the circuit board 163 is disposed substantially at the center in the front-rear direction.
  • the battery 164 is a rechargeable lithium ion battery, for example, and has an outer shape of a rectangular plate.
  • the battery 164 is disposed on the rear side of the circuit board 163.
  • the blower 165 is a centrifugal fan, and a plurality of blades 165a are rotationally driven around an axis in the front-rear direction by a motor 165b.
  • the blower 165 is disposed with a gap on the front side of the circuit board 163, and the gap communicates with a suction port 131 a provided in the body portion 131 of the housing 121, and constitutes an upstream side passage 167 a. .
  • the ion generator 166 is disposed above the circuit board 163, and a negative high voltage and a positive high voltage are applied to the two discharge electrodes of the ion generator 166, respectively. Will occur.
  • the positive ions and negative ions generated by the ion generator 166 are blown out from the outlets 132a and 132b together with the air flowing through the downstream side passage 167c.
  • Example 1 (A) 6 hours after application of cosmetics, positive and negative ions and wind are applied to a human three-dimensional cultured epidermis model (Labsite Epi Model 12, manufactured by Japan Tissue Engineering Co., Ltd.) in which normal human epidermis cells are layered. (Example 1), (b) After application of cosmetics, only 6 hours of wind was irradiated (air blowing conditions were the same as in Example 1) (Comparative Example 1), (c) Naturally left for 6 hours after application of cosmetics In the three cases (Comparative Example 2), the level of penetration of cosmetic ingredients into the skin was observed.
  • a fluorescent labeled ceramide C-12 NBD-D-erythro-sphingosine (C-12 NBD Ceramide, Cayman Chemical)
  • a cosmetic ingredient skin permeation enhancer plasma cluster bedside
  • Irradiation was performed by adjusting the ion generating part and the air blowing part of Moisture IB-BS12 (manufactured by Sharp Corporation).
  • the other ingredients of the cosmetic were water, ethanol, glycerin, butylene glycol, and PEG 60 hydrogenated castor oil generally used in cosmetics.
  • the penetration level of the fluorescent ceramide was judged by observing the cross section of the epidermis model with a fluorescence microscope.
  • FIG. 8 is a photograph showing the results of Experimental Example 1.
  • FIG. 8 (a) shows Example 1
  • FIG. 8 (b) shows Comparative Example 1
  • FIG. 8 (c) shows Comparative Example 2.
  • FIG. 8 (a) after applying cosmetics, when positive and negative ions and wind are irradiated (Example 1), the skin is deeper than cosmetics alone (not only the stratum corneum surface but also the granular layer, It can be seen that fluorescent ceramide has penetrated (up to the spinal layer).
  • Cosmetics are applied and only the wind is irradiated
  • the penetration of the surface of the stratum corneum is the same as in the case of cosmetics application only (Comparative Example 2). It turns out that it is an effect.
  • ceramide-containing lotion in an environment of room temperature of 21 ° C. and humidity of 39 to 40%, 50 ⁇ L of ceramide-containing lotion is applied to a range of 5 cm square inside the human forearm, and then 100 and 100 positive ions and negative ions are respectively applied to the applied portion. Irradiation was carried out by adjusting the ion generating part and the air blowing part of a cosmetic ingredient skin permeation promoting device (Plasma Cluster Bedside Moisture IB-BS12, manufactured by Sharp Corporation) so that the ion concentration was 000 / cm 3 .
  • the other ingredients of the cosmetic were water, ethanol, glycerin, butylene glycol, and PEG 60 hydrogenated castor oil generally used in cosmetics.
  • the amount of ceramide permeating into the stratum corneum was determined by peeling the skin surface (corneal layer) with tape 2 ⁇ 5 cm, and quantifying the ceramide in the collected stratum corneum by HPLC.
  • FIG. 9 is a graph showing the results of Experimental Example 2, where the ordinate represents the amount of ceramide detected ( ⁇ g / ml), the abscissa represents no PCI (Comparative Example 3), and PCI (Example 2), respectively. Show. In the results shown in FIG. 9, the amount of ceramide detected was 3.160 ⁇ g / ml when both positive and negative ions and wind were irradiated after the cosmetic application (Example 2), whereas 2 2 after the cosmetic application.

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Electrotherapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne un procédé permettant de favoriser la pénétration d'un ingrédient de soin de beauté dans la peau, ledit procédé comprenant les étapes consistant à amener l'ingrédient de soin de beauté en contact avec la peau puis à rayonner l'ingrédient de soin de beauté avec des ions positifs et des ions négatifs chacun liés à une molécule d'eau, les ions positifs et les ions négatifs étant générés par décharge électrique dans l'atmosphère ; et un dispositif permettant de favoriser la pénétration dans la peau, ledit dispositif étant utilisé pour favoriser la pénétration d'un ingrédient de soin de beauté dans la peau et comprenant une unité de génération d'ions et une unité de soufflage d'air, ladite unité de génération d'ions pouvant générer des ions positifs et des ions négatifs chacun liés à une molécule d'eau par décharge électrique dans l'atmosphère, et l'unité de soufflage d'air étant utilisée pour fournir des ions négatifs et des ions positifs à l'intérieur de la peau entrée en contact avec l'ingrédient de soin de beauté. Il devient ainsi possible de fournir un procédé et un dispositif permettant tous deux la pénétration d'un ingrédient de soin de beauté dans la peau de manière plus simple par comparaison avec les procédés et les dispositifs traditionnels.
PCT/JP2015/052652 2014-04-10 2015-01-30 Procédé permettant de favoriser la pénétration d'un ingrédient de soin de beauté dans la peau et dispositif permettant de favoriser la pénétration d'un ingrédient de soin de beauté dans la peau WO2015156017A1 (fr)

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Application Number Priority Date Filing Date Title
CN201580008864.0A CN106061542A (zh) 2014-04-10 2015-01-30 促进美容成分向皮肤渗透的方法和皮肤渗透促进装置
JP2016512614A JPWO2015156017A1 (ja) 2014-04-10 2015-01-30 美容成分の皮膚への浸透を促進する方法および皮膚浸透促進装置

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JP2014081071 2014-04-10
JP2014-081071 2014-04-10

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Cited By (1)

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WO2023048130A1 (fr) 2021-09-21 2023-03-30 株式会社アイシン Agent topique pour la peau et les cheveux, procédé d'utilisation de produit cosmétique et dispositif de fourniture de fines particules d'eau

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CN108144181A (zh) * 2018-01-08 2018-06-12 深圳市易美嘉科技有限公司 可增强吸收的便携式负离子雾化美容仪

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JP2011200722A (ja) * 2009-10-09 2011-10-13 Sharp Corp 肌表面の水分量を増加させると共に真皮の水分保持機能を向上させる美容器具
JP2014045968A (ja) * 2012-08-31 2014-03-17 Sharp Corp 口唇の保湿方法および美容器具
JP2014059105A (ja) * 2012-09-18 2014-04-03 Sharp Corp イオン発生システム及びイオン発生装置

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JP2003159305A (ja) * 2001-09-13 2003-06-03 Matsushita Electric Works Ltd 肌ケア装置
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US20130184513A1 (en) * 2010-11-30 2013-07-18 Sharp Kabushiki Kaisha Skin care method and skin care device
JP5066284B1 (ja) * 2011-05-12 2012-11-07 シャープ株式会社 毛髪の加湿及び損傷軽減方法並びに毛髪の加湿及び損傷軽減装置
KR20140121835A (ko) * 2012-02-24 2014-10-16 후지필름 가부시키가이샤 피부 외용제 및 정상 피부세포 부활화제
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JP2011200722A (ja) * 2009-10-09 2011-10-13 Sharp Corp 肌表面の水分量を増加させると共に真皮の水分保持機能を向上させる美容器具
JP2014045968A (ja) * 2012-08-31 2014-03-17 Sharp Corp 口唇の保湿方法および美容器具
JP2014059105A (ja) * 2012-09-18 2014-04-03 Sharp Corp イオン発生システム及びイオン発生装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023048130A1 (fr) 2021-09-21 2023-03-30 株式会社アイシン Agent topique pour la peau et les cheveux, procédé d'utilisation de produit cosmétique et dispositif de fourniture de fines particules d'eau

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