WO2015141408A1 - Instrument médical - Google Patents

Instrument médical Download PDF

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Publication number
WO2015141408A1
WO2015141408A1 PCT/JP2015/055219 JP2015055219W WO2015141408A1 WO 2015141408 A1 WO2015141408 A1 WO 2015141408A1 JP 2015055219 W JP2015055219 W JP 2015055219W WO 2015141408 A1 WO2015141408 A1 WO 2015141408A1
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WO
WIPO (PCT)
Prior art keywords
lumen
stent
outer tube
refrigerant
medical device
Prior art date
Application number
PCT/JP2015/055219
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English (en)
Japanese (ja)
Inventor
賢二 大山
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to JP2016508625A priority Critical patent/JPWO2015141408A1/ja
Publication of WO2015141408A1 publication Critical patent/WO2015141408A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod

Definitions

  • the present invention relates to a medical instrument.
  • a cylindrical stent is placed in the blood vessel to widen the stenosis (occlusion), which is the target site, and a treatment method for ensuring blood flow is known. It has been.
  • a stent delivery system is used as a medical instrument that transports and places a stent to a target site (see, for example, Patent Document 1).
  • the medical device described in Patent Document 1 includes a balloon catheter having a balloon that can be inflated and deflated at the tip.
  • the stent In order to transport the stent to the target site, first, the stent is mounted on the outside of the deflated balloon, and the stent is transported to the target site as it is. Thereafter, the balloon is inflated. As a result, the stent is expanded and plastically deformed to maintain the expanded state.
  • the stent of Patent Document 1 is made of a shape memory alloy that is restored to an expanded shape by heating at a temperature higher than the body temperature. Therefore, the medical instrument described in Patent Document 1 includes a heating element that heats the stent.
  • the heating element is composed of a coil that generates heat when energized.
  • the said stent can be heated with a heating element. As a result, the stent is brought into close contact with the blood vessel wall, and is thus reliably placed at the target site.
  • the medical device described in Patent Document 1 has a complicated structure such as a wiring for energizing the heating element in addition to the heating element, and this complexity hinders a quick procedure. There is a risk of becoming.
  • there is an optimum temperature for heating the stent when the temperature is lower than this temperature, the shape of the stent is not restored, that is, the expansion is insufficient, and as a result, the degree of adhesion with the blood vessel wall is insufficient. Then, there is a risk that the target part will deviate. On the other hand, if the temperature is higher than the optimum temperature, there is a risk that the blood vessel wall may be burned.
  • An object of the present invention is to provide a medical instrument that can perform a placement operation quickly, reliably, and safely when placing a stent in a blood vessel.
  • a medical device for placing a stent to be used in a blood vessel in the blood vessel A medical instrument comprising: an outer tube having a first lumen that houses the stent in a contracted state and a second lumen through which a coolant that cools the stent in the contracted state passes.
  • the stent has a cylindrical shape and is composed of a superelastic metal that expands due to the elastic force of the stent itself.
  • the first lumen has a distal end opening that opens at the distal end of the outer tube and is released while the stent in the contracted state is expanded; Before releasing the stent through the tip opening, the refrigerant is supplied to the second lumen, and when releasing the stent, the refrigerant is discharged from the second lumen.
  • the first lumen has a distal end opening that opens to the distal end of the outer tube and is released while the contracted stent is expanded, Before releasing the stent through the tip opening, the coolant has not been supplied to the second lumen, and when the stent is released, the refrigerant is discharged while the second lumen is released.
  • the outer tube communicates with the second lumen, and supplies the refrigerant to the second lumen.
  • the outer tube communicates with the second lumen and is supplied to the second lumen.
  • the medical device according to any one of (1) to (4), further including a discharge unit that discharges the refrigerant.
  • a heating mechanism for heating and expanding the cooled stent can be omitted, and thus the structure of the medical device can be simplified. Thereby, operation of a medical instrument becomes easy and the indwelling operation at the time of indwelling a stent in a blood vessel can be performed rapidly.
  • the body temperature can be used for heating the cooled stent, the stent can be surely heated above the transformation point of the superelastic metal. This ensures that the stent is expanded and the stent placement operation is ensured. In addition, it is possible to reliably prevent a risk of burns on the blood vessel wall, and the safety during the stent placement operation is high.
  • FIG. 1 is a longitudinal cross-sectional view sequentially illustrating an operation process of the medical instrument (first embodiment) of the present invention.
  • FIG. 2 is a longitudinal cross-sectional view sequentially illustrating an operation process of the medical instrument (first embodiment) of the present invention.
  • FIG. 3 is a longitudinal cross-sectional view sequentially illustrating the operation process of the medical instrument (first embodiment) of the present invention.
  • 4 is a cross-sectional view taken along line AA in FIG.
  • FIG. 5 is a longitudinal sectional view showing a second embodiment of the medical instrument of the present invention.
  • FIG. 6 is a perspective view showing a third embodiment of the medical instrument of the present invention.
  • FIGS. 1 to 3 are longitudinal sectional views sequentially showing the operation process of the medical device (first embodiment) of the present invention.
  • 4 is a cross-sectional view taken along line AA in FIG.
  • the right side in FIGS. 1 to 3 (the same applies to FIGS. 5 and 6) is referred to as “base end” and the left side is referred to as “tip”.
  • the thickness direction of the guide wire is schematically shown exaggerated for easy understanding. The direction ratio is different from the actual one.
  • the medical device 1 shown in FIGS. 1 to 3 is a stent delivery system in which a stent 100 is arranged in a peripheral region such as a blood vessel of a lower limb.
  • the medical instrument 1 includes an instrument body 10 having a double tube structure having an outer tube 2 and an inner tube 3, an operation unit 4 for relatively moving the outer tube 2 and the inner tube 3, and an operation unit. 4 and a hub 5 that supports 4.
  • the stent 100 When a stenosis part or a blockage part (hereinafter referred to as “stenosis part”) occurs in the blood vessel wall, the stent 100 can be placed in the blood vessel to expand the stenosis part as a target site from the inside. Thereby, the blood flow in the blood vessel is ensured.
  • stenosis part a stenosis part or a blockage part
  • the stent 100 is a combination of a large number of linear bodies 101 in a stitch shape, and the overall shape forms a cylindrical shape.
  • the constituent material of the linear body 101 is a superelastic alloy that exhibits superelasticity in vivo (at least around 37 ° C.).
  • Superelastic alloys include any shape of the stress-strain curve caused by tension, including those where the transformation point (Af point) can be measured remarkably and those that cannot be measured. This includes everything that almost returns to its original shape.
  • the preferred composition of the superelastic alloy is a Ni—Ti alloy such as a Ni—Ti alloy of 49 to 52 atomic% Ni, a Cu—Zn alloy of 38.5 to 41.5 wt% Zn, 1 to 10 wt% X Cu—Zn—X alloy (X is at least one of Be, Si, Sn, Al, and Ga), Ni-Al alloy of 36 to 38 atomic% Al, and the like.
  • X is at least one of Be, Si, Sn, Al, and Ga
  • Ni-Al alloy of 36 to 38 atomic% Al, and the like.
  • the Ni—Ti alloy is particularly preferable.
  • the stent 100 expands to return to its original shape by the elastic force of the stent 100 itself, that is, an expansion force (Radial ⁇ Force) RF. Can be spread reliably from the inside.
  • the expansion force RF is suppressed under a temperature lower than the transformation point.
  • the transformation point is preferably lower than the in vivo temperature, for example, about 18 to 28 ° C.
  • the medical instrument 1 is used for arranging such a stent 100 in a blood vessel.
  • the medical instrument 1 includes the instrument main body 10 having the outer tube 2 and the inner tube 3, the operation unit 4, and the hub 5.
  • the configuration of each unit will be described.
  • the outer tube 2 has a first lumen 21, a second lumen 22, and a third lumen 23, which are concentrically from the inside toward the outside. It is an arranged flexible tube.
  • the total length of the outer tube 2 is not particularly limited, and is preferably 500 to 2000 mm, and more preferably 800 to 1500 mm, for example, when used for the treatment of a peripheral region.
  • the constituent material of the outer tube 2 is not particularly limited.
  • polyolefin such as polypropylene, polyethylene, and ethylene-vinyl acetate copolymer
  • polyester such as polyamide, polyethylene terephthalate, and polybutylene terephthalate
  • polyurethane polyvinyl chloride
  • polystyrene polystyrene.
  • fluorine resin such as ethylene-tetrafluoroethylene copolymer
  • various flexible resins such as polyimide, polyamide elastomer, polyester elastomer, polyurethane elastomer, polystyrene elastomer, fluorine elastomer, silicone rubber, latex rubber, etc.
  • elastomers, or a combination of two or more of them can be used.
  • the first lumen 21 is a space for storing the stent 100 in a contracted state in which the stent 100 is contracted.
  • the first lumen 21 has a distal end opening 211 opened at the distal end (distal end) of the outer tube 2 and a proximal end opening 212 opened at the proximal end (proximal end) of the outer tube 2. . Then, the stent 100 in the contracted state (stored state) is released while being expanded (see FIG. 3).
  • the second lumen 22 is a lumen that is disposed outside the first lumen 21 and through which the refrigerant C passes.
  • the stored stent 100 stored in the first lumen 21 can be cooled.
  • the cooling temperature is below the transformation point of the superelastic metal.
  • the transformation point is about 18 to 28 ° C., it is preferably ⁇ 50 to 18 ° C., more preferably 0 to 10 ° C. .
  • the expansion force RF of the stent 100 can be reliably reduced, and therefore, the operation for releasing the stent 100 from the distal end opening 211 can be easily performed as will be described later.
  • coolant C For example, a physiological saline, a contrast agent, etc. are mentioned.
  • the second lumen 22 has a distal end closed side portion 221 whose distal end is closed by the distal end wall portion 24 of the outer tube 2 and a proximal end opening portion 222 whose proximal end is opened.
  • a port 25 that communicates with the second lumen 22 through the proximal end opening 222 is provided.
  • the port 25 functions as a supply unit (see FIG. 2) for supplying the refrigerant C to the second lumen 22, and as a discharge unit (see FIG. 3) for discharging the refrigerant C supplied to the second lumen 22.
  • This is a supply / discharge port with functions. That is, the port 25 is a portion where the supply unit and the discharge unit are combined. Thereby, compared with the case where a supply part and a discharge part are each provided separately, the structure of the medical instrument 1 can be made simple.
  • the port 25 protrudes in a tubular shape from the operation unit 4 and is connected to the pump 12 via the pipe 11.
  • a valve 13 is provided in the middle of the pipe 11.
  • the pump 12 is connected to the tank 15 via a pipe 14.
  • the tank 15 is filled with a sufficiently cooled refrigerant C.
  • the refrigerant C sequentially passes through the pipe 14, the pump 12, the pipe 11, and the port 25, The second lumen 22 is reached. Thereby, the refrigerant C is supplied to the second lumen 22.
  • the pump 12 in the direction opposite to the above (reversely rotating), as shown in FIG.
  • the refrigerant C passes through the port 25, the pipe 11, the pump 12, and the pipe 14 in this order, and the tank 15 is reached. Thereby, the refrigerant C is discharged from the second lumen 22. Note that the valve 13 is closed while the pump 12 is stopped.
  • the third lumen 23 is a lumen that is disposed outside the second lumen 22 and exhibits a heat insulating function that blocks heat from the outside of the outer tube 2. Thereby, it is possible to prevent the refrigerant C passing through the second lumen 22 from being heated and heated and unintentionally increasing its temperature, and thus the stent 100 can be sufficiently and reliably cooled. it can.
  • the third lumen 23 can be filled with gas G. Thereby, as shown in FIG. 2, the third lumen 23 expands, and the heat insulating function in the third lumen 23 is reliably exhibited.
  • gas G For example, air, a carbon dioxide, nitrogen etc. are mentioned.
  • a heat insulating material such as a porous material may be filled.
  • the third lumen 23 has a distal end closed side portion 231 whose distal end is closed by the distal end wall portion 24 of the outer tube 2 and a proximal end opening portion 232 whose proximal end is opened. is doing.
  • a port 26 that communicates with the third lumen 23 via the proximal end opening 232 is provided.
  • the port 26 functions as a supply unit (see FIG. 2) for supplying the gas G to the third lumen 23 and as a discharge unit (see FIG. 3) for discharging the gas G supplied to the third lumen 23.
  • This is a supply / discharge port with functions. That is, the port 26 is a portion where the supply unit and the discharge unit are combined.
  • the port 26 protrudes in a tubular shape from the operation unit 4 in the same direction as the port 26, and is connected to the pump 17 via the pipe 16.
  • a valve 18 is provided in the middle of the pipe 16. Then, by opening the valve 18 and operating the pump 17 (forward rotation), as shown in FIG. 2, the gas G is sucked from the pump 17 and sequentially passes through the pipe 16 and the port 26. The third lumen 23 is reached. Thereby, the gas G is supplied to the third lumen 23. Further, by operating the pump 17 in the opposite direction (reverse rotation), the gas G passes through the port 26 and the pipe 16 in this order and reaches the pump 17 as shown in FIG. As a result, the gas G is discharged from the third lumen 23. Note that the valve 18 is closed while the pump 17 is stopped.
  • the first lumen 21, the second lumen 22, and the third lumen 23 are arranged concentrically in order from the inside to the outside of the outer tube 2.
  • the stent 100 in the first lumen 21 can be reliably cooled by the refrigerant C in the second lumen 22 from any position around the circumference.
  • the refrigerant C can be surely insulated from the gas G in the third lumen 23 from any position around the circumference.
  • the operation unit 4 is connected and fixed to the base end of the outer tube 2. As shown in FIG. 3, the operation part 4 moves the outer tube 2 with respect to the inner tube 3 along its longitudinal direction.
  • the operation unit 4 has a lever 41 protruding in a direction orthogonal to the moving direction of the outer tube 2.
  • a finger can be put on the lever 41, and in this state, the lever 41 can be pulled toward the proximal end or pushed toward the distal end.
  • pipe 2 can move toward a base end direction independently of the inner tube
  • the hub 5 supports the operation unit 4 so as to be movable.
  • the hub 5 has a box shape, for example, and a lever 41 protrudes from the outer surface thereof.
  • the hub 5 can be gripped with one hand and the lever 41 can be operated with the other hand.
  • the constituent material of the operation unit 4 and the hub 5 is not particularly limited, and for example, various resin materials and various metal materials can be used.
  • the inner tube 3 is inserted through the first lumen 21 of the outer tube 2.
  • the base end portion of the inner tube 3 is fixed to the hub 5.
  • the inner tube 3 has a lumen 31 through which the guide wire 200 is inserted.
  • the lumen 31 has a distal end opening 311 that opens to the distal end (distal end) of the inner tube 3 and a proximal end opening 312 that opens to the proximal end (proximal end) of the inner tube 3.
  • the guide wire 200 can be inserted into the lumen 31 via the proximal end opening 312 and protrude from the distal end opening 311.
  • the total length of the inner tube 3 is preferably longer than the total length of the outer tube 2.
  • the distal end portion 32 of the inner tube 3 can be projected from the distal end opening portion 211 of the first lumen 21 of the outer tube 2, so that the guide wire 200 projecting from the inner tube 3 guides in the blood vessel. Can be performed reliably.
  • an enlarged diameter portion 33 having an enlarged outer diameter is provided.
  • the enlarged-diameter portion 33 has a contrast property and is used to confirm the position of the distal end portion of the instrument main body portion 10 in the blood vessel under X-ray contrast.
  • a method in which a particulate X-ray opaque material is contained or the X-ray opaque material itself is used.
  • the radiopaque material for example, a noble metal such as gold, platinum, tungsten, or an alloy containing these (eg, platinum-iridium alloy) can be used.
  • the enlarged diameter portion 33 is disposed in the immediate vicinity of the proximal end side of the stent 100 housed in the first lumen 21 of the outer tube 2.
  • the stent 100 can be restricted from moving in the same direction together with the outer tube 2.
  • the diameter-enlarged portion 33 also functions as a restricting portion that restricts the movement of the stent 100 in the proximal direction.
  • the constituent material of the inner tube 3 is not particularly limited, and for example, those listed as the constituent material of the outer tube 2 can be used. In this case, the constituent material of the inner tube 3 and the constituent material of the outer tube 2 may be the same or different.
  • an initial medical device 1 is prepared at room temperature.
  • the stent 100 is stored and attached in advance in the first lumen 21 of the outer tube 2 in a contracted state.
  • the stent 100 is expanded to return to its original shape with its own expansion force RF1.
  • the outer peripheral portion 102 of the stent 100 is in close contact with the inner peripheral portion 213 that defines the first lumen 21, so that the stent 100 is reliably prevented from being detached from the first lumen 21.
  • the guide wire 200 is inserted into the inner tube 3 in this state, and the distal end opening 211 of the medical instrument 1 is inserted to the target site in the blood vessel while the guide wire 200 is advanced.
  • the refrigerant C is supplied into the second lumen 22 of the outer tube 2 and the gas G is supplied into the third lumen 23.
  • the 2nd lumen 22 and the 3rd lumen 23 each expand
  • the inner peripheral portion 213 of the first lumen 21 is reduced in diameter. Thereby, the stent 100 is pressed from the inner peripheral part 213 and further contracts compared to the initial state.
  • the stent 100 is sufficiently cooled by the refrigerant C in the second lumen 22 at a temperature lower than the transformation point.
  • the stent 100 is made of a superelastic alloy, and the expansion force RF2 is suppressed at a temperature lower than the transformation point. Therefore, the expansion force RF2 during cooling is smaller than the expansion force RF1. .
  • the degree of adhesion between the outer peripheral portion 102 of the stent 100 and the inner peripheral portion 213 of the first lumen 21 is reduced, and the stent 100 is easily detached from the first lumen 21.
  • the refrigerant C can be insulated by the gas G supplied into the third lumen 23, and therefore, the temperature rise of the refrigerant C due to body temperature can be prevented. Thereby, the stent 100 can be reliably cooled with the refrigerant C. On the other hand, it is possible to prevent the blood vessel wall from being cooled by the refrigerant C by the gas G in the third lumen 23.
  • the outer diameter of the outer tube 2 increases as a whole. Therefore, the part which the outer tube
  • the stent 100 is gradually released from the distal end opening 211 of the outer tube 2.
  • the protruding portion 103 protruding from the distal end opening portion 211 of the outer tube 2 of the stent 100 is exposed to blood and is heated above the transformation point. Thereby, the protrusion 103 is expanded and expanded with the expansion force RF1.
  • the operation at the operation unit 4 is performed until the entire stent 100 is released into the blood vessel. Thereby, the deployed stent 100 can be placed in the blood vessel.
  • the refrigerant C is recovered from the second lumen 22 while releasing the stent 100. Accordingly, excessive cooling of the stent 100 is prevented, and thus the stent 100 is heated more rapidly than the transformation point after protruding from the distal end opening 211.
  • the refrigerant C is supplied again into the first lumen 21 to expand the stent 100. Can be suppressed.
  • the refrigerant C is recovered and the gas G is recovered from the third lumen 23.
  • the refrigerant C is supplied to the second lumen 22 before the stent 100 is released through the distal end opening 211 of the first lumen 21, and the expansion force RF of the stent 100 is increased. It can be reliably lowered. Thereby, when the operation of releasing the stent 100 is performed, the sliding resistance between the outer peripheral portion 102 of the stent 100 and the inner peripheral portion 213 of the first lumen 21 is sufficiently reduced, and thus the operation is facilitated. And can be done quickly. As a result, the placement operation when placing the stent 100 in the blood vessel can be performed quickly.
  • body temperature is used for heating the stent 100 without heating it with a separately provided heating mechanism, for example.
  • the heating mechanism can be omitted, and thus the device configuration of the medical instrument 1 is simplified, and the danger of causing burns to the blood vessel wall is reliably prevented, and safety is improved. high.
  • the stent 100 is reliably heated above the transformation point by the body temperature, an expansion force RF that can be deployed without excess or deficiency is obtained. This ensures that the stent 100 is placed in the blood vessel.
  • the stent 100 presses the inner tube 3 in the proximal direction through the enlarged diameter portion 33. Due to this pressing, the inner tube 3 is partially bent, that is, undulated, and a phenomenon called “shortening” occurs in which the stent 100 is also retracted from the target site toward the proximal end.
  • the sliding resistance is sufficiently reduced, the inner tube 3 is prevented from receiving a pressing force of a level of undulation. Thereby, shortening can be prevented.
  • FIG. 5 is a longitudinal sectional view showing a second embodiment of the medical instrument of the present invention.
  • This embodiment is the same as the first embodiment except that the operation method of the medical instrument is different.
  • the refrigerant C is not yet supplied to the second lumen 22, and the gas G is also supplied to the third lumen 23. Is not supplied.
  • the refrigerant C is supplied to the second lumen 22 and the gas G is supplied to the third lumen 23 while releasing the stent 100.
  • the stent 100 is heated more rapidly than the transformation point after protruding from the distal end opening 211.
  • the operation for releasing the stent 100 and the operation for supplying the refrigerant C are performed at the same time, the procedure using the medical instrument 1 can be performed more quickly.
  • FIG. 6 is a perspective view showing a third embodiment of the medical instrument of the present invention.
  • This embodiment is the same as the first embodiment except that the shape of the second lumen is different.
  • the second lumen 22 has a spiral portion 223 having a spiral shape at the distal end portion thereof.
  • the spiral portion 223 is disposed concentrically between the first lumen 21 and the third lumen 23, and the stent 100 in the first lumen 21 is viewed from the side of the instrument body 10. overlapping. Thereby, the stent 100 can be cooled reliably.
  • the proximal end side of the spiral portion 223 communicates with the port 25, and the distal end side communicates with a port 27 provided separately from the port 25.
  • the port 27 protrudes in a tubular shape from the operation unit 4 like the port 25 and is connected to the tank 15 via the pipe 19. Then, the refrigerant C is supplied to the spiral portion 223 through the port 25 and then discharged through the port 27.
  • the port 25 is a supply port that functions as a supply unit
  • the port 27 is a discharge port that functions as a discharge unit.
  • the valve 13 is opened and the refrigerant C is circulated to cool the stent 100. After the stent 100 is released, the valve 13 is closed and the circulation of the refrigerant C is stopped.
  • the medical instrument 1 may be configured so that the valve 13 can be in an open state and a closed state in conjunction with the movement operation of the outer tube 2.
  • the third lumen 23 may be configured so that the gas G circulates similarly to the refrigerant C.
  • each part which comprises a medical instrument is a thing of arbitrary structures which can exhibit the same function Can be substituted. Moreover, arbitrary components may be added.
  • the medical instrument of the present invention may be a combination of any two or more configurations (features) of the above embodiments.
  • the second lumen is formed in a spiral shape so that the refrigerant reciprocates.
  • the second lumen simply has a “U” shape, so that the refrigerant is It may be configured to reciprocate.
  • a wall portion is provided to divide the second lumen along the circumferential direction of the outer tube into two lumens in the circumferential direction on the base end side from the distal end portion thereof, whereby the refrigerant reciprocates. Also good.
  • the second lumen may meander, and the refrigerant may reciprocate a plurality of times around the stent.
  • the medical device of the present invention is a medical device for placing a stent used by being placed in a blood vessel in the blood vessel, the first lumen housing the stent in a contracted state, and cooling the stent in the contracted state. And an outer tube having a second lumen through which the refrigerant passes. Therefore, when placing a stent in a blood vessel, the placement operation can be performed quickly, reliably and safely. Therefore, the medical device of the present invention has industrial applicability.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

La présente invention concerne un instrument médical à utiliser pour implanter une endoprothèse vasculaire à demeure dans un vaisseau sanguin. L'instrument médical est pourvu d'un tube externe, ledit tube externe comprenant une première lumière servant à y loger l'endoprothèse dans un état contracté et une seconde lumière permettant la traversée d'un réfrigérant pour refroidir l'endoprothèse dans l'état contracté. L'endoprothèse a une forme tubulaire et est conçue à partir d'un métal super-élastique qui permet le déploiement de l'endoprothèse dû, en soi, à la force élastique de l'endoprothèse. L'instrument médical permet de réduire la force de déploiement de l'endoprothèse par refroidissement de l'endoprothèse au moyen du réfrigérant à une température inférieure ou égale à la température de transformation du métal super-élastique.
PCT/JP2015/055219 2014-03-19 2015-02-24 Instrument médical WO2015141408A1 (fr)

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JP2014-057289 2014-03-19
JP2014057289 2014-03-19

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019503213A (ja) * 2015-12-03 2019-02-07 インサイテック リミテッド 前立腺の治療中に使用するための尿道カテーテル、システムおよび方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01119266A (ja) * 1987-11-02 1989-05-11 Terumo Corp 体腔の内径確保用装置
US5224953A (en) * 1992-05-01 1993-07-06 The Beth Israel Hospital Association Method for treatment of obstructive portions of urinary passageways
JP2000288092A (ja) * 1999-04-12 2000-10-17 Tomio Ota カテーテル
JP2003524506A (ja) * 2000-03-01 2003-08-19 イナークール セラピーズ インコーポレイテッド 再狭窄を伴う血管形成術のための冷却療法及び装置
JP2007503250A (ja) * 2003-08-26 2007-02-22 ボストン サイエンティフィック サイムド， インコーポレイテッド ステント・デリバリー・システム

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01119266A (ja) * 1987-11-02 1989-05-11 Terumo Corp 体腔の内径確保用装置
US5224953A (en) * 1992-05-01 1993-07-06 The Beth Israel Hospital Association Method for treatment of obstructive portions of urinary passageways
JP2000288092A (ja) * 1999-04-12 2000-10-17 Tomio Ota カテーテル
JP2003524506A (ja) * 2000-03-01 2003-08-19 イナークール セラピーズ インコーポレイテッド 再狭窄を伴う血管形成術のための冷却療法及び装置
JP2007503250A (ja) * 2003-08-26 2007-02-22 ボストン サイエンティフィック サイムド， インコーポレイテッド ステント・デリバリー・システム

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JP2019503213A (ja) * 2015-12-03 2019-02-07 インサイテック リミテッド 前立腺の治療中に使用するための尿道カテーテル、システムおよび方法

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