WO2015125392A1 - 皮膚用化粧料組成物、皮膚用化粧料用抗菌剤及びジオール化合物が有する抗菌効果の増強方法 - Google Patents
皮膚用化粧料組成物、皮膚用化粧料用抗菌剤及びジオール化合物が有する抗菌効果の増強方法 Download PDFInfo
- Publication number
- WO2015125392A1 WO2015125392A1 PCT/JP2014/083201 JP2014083201W WO2015125392A1 WO 2015125392 A1 WO2015125392 A1 WO 2015125392A1 JP 2014083201 W JP2014083201 W JP 2014083201W WO 2015125392 A1 WO2015125392 A1 WO 2015125392A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- component
- ether
- skin
- skin cosmetic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- the present invention relates to a skin cosmetic, antibacterial agent for skin cosmetic, and a method for enhancing the antibacterial effect of a diol compound, which is highly safe against human skin and has a good antibacterial effect.
- antibacterial agents are usually used for antiseptic purposes.
- the most used as such antibacterial agents are parabens.
- parabens Although parabens have low toxicity, they have the disadvantage that the concentration range for use is limited due to high skin irritation. Therefore, the use concentration of parabens in cosmetics is limited to 1% or less.
- an increasing number of people have an allergic reaction to parabens. Since people who have an allergic reaction also react to parabens at extremely low concentrations, there is an increasing demand for cosmetics that do not contain parabens.
- cosmetics that do not use antibacterial agents have poor storage stability and are difficult to manage as products, antibacterial agents that are highly safe for the human body have been demanded.
- diol compounds such as alkane diols and alkyl glyceryl ethers, and compounds obtained by adding alkylene oxide to these diol compounds as antibacterial agents (see, for example, Patent Documents 1 to 3).
- These compounds are characterized by high safety to the human body compared to parabens while having good performance as antibacterial agents.
- the problem to be solved by the present invention is to provide a skin cosmetic composition having a high safety to the human body and a high antibacterial effect, an antibacterial agent for skin cosmetics, and a method for enhancing the antibacterial effect of a diol compound. There is to do.
- the present inventors diligently studied and found a composition that is highly safe for the human body and also has a high antibacterial effect, leading to the present invention. That is, the present invention relates to the component (A) which is one or two selected from hexyl glyceryl ether and cyclohexyl glyceryl ether, one or two selected from 1,2-propanediol and 1,3-propanediol.
- component (A) is one or two selected from hexyl glyceryl ether and cyclohexyl glyceryl ether, one or two selected from 1,2-propanediol and 1,3-propanediol.
- Component (B) as well as citric acid, lactic acid, hydroxyethylethylenediaminetriacetic acid, hydroxyethyliminodiacetic acid, dihydroxyethylglycine, gluconic acid, phytic acid, pentethic acid, etidronic acid, tartaric acid and their salts, and gluco
- C cosmetic composition for skin containing (C) component which is 1 type (s) or 2 or more types selected from the group which consists of nolactone.
- the present invention provides an antibacterial agent for skin cosmetics comprising the component (A), the component (B) and the component (C), the component (A), the component (B) and the component (C).
- a method for enhancing the antibacterial effect of the component (A) in the skin cosmetic which comprises adding to the skin cosmetic.
- the skin cosmetic composition according to the present invention has high safety to the human body and high antibacterial effect.
- the cosmetic composition for skin of the present invention has little irritation to the skin and excellent usability.
- the component (A) used in the present invention is hexyl glyceryl ether represented by the following formula (1) and cyclohexyl glyceryl ether represented by the following formula (2), and only one of them is used. Alternatively, the two components may be mixed and used.
- any known method may be used.
- hexanol and glycerol are subjected to a dehydration condensation reaction
- hexyl chloride, hexyl bromide and glycerol are dehydrochlorinated or debrominated.
- the above reaction is performed using glycerin partially esterified with a lower fatty acid, and a saponification after the reaction is completed to remove the fatty acid, or a partial ketalized product of glycerin
- a product with high purity can be obtained.
- a cyclohexyl glyceryl ether by the same method as the above, replacing the hexanol of a raw material with a cyclohexanol.
- Both hexyl glyceryl ether and cyclohexyl glyceryl ether are those in which glycerin is bonded to a hydrocarbon group having 6 carbon atoms through an ether bond, but are good for compounds in which glycerin is bonded to a hydrocarbon group having 5 or less carbon atoms through an ether bond. Antibacterial effect is not obtained.
- a compound in which glycerin is bonded to a hydrocarbon group having 7 or more carbon atoms by an ether bond may increase irritation to the skin.
- the component (B) used in the present invention is 1,2-propanediol (propylene glycol) and 1,3-propanediol, and either one of them can be used or two components can be used simultaneously. Good. When tripropylene glycol or polypropylene glycol is used, a good antibacterial effect cannot be obtained. In addition, 1,2-propanediol and 1,3-propanediol are less irritating than other polyhydric alcohols, and are excellent in safety and use as cosmetics, and there is almost no difference in performance due to the structure of these two compounds. Absent. However, it is preferable to use 1,2-propanediol because it is easily available and used for general purposes.
- Component (C) used in the present invention is citric acid, lactic acid, hydroxyethylethylenediaminetriacetic acid, hydroxyethyliminodiacetic acid, dihydroxyethylglycine, gluconic acid, phytic acid, pentetic acid, etidronic acid, tartaric acid and salts thereof. Moreover, it is gluconolactone, and one kind of these groups may be used or two or more kinds may be used simultaneously.
- the component (C) having an acid form may be used in the form of an acid, or may be used in the form of a salt after complete neutralization or partial neutralization. Examples of the salt include sodium salt, potassium salt, An ammonium salt etc. are mentioned.
- the component (C) is roughly classified into hydroxycarboxylic acids and phosphoric acids, but there is almost no performance difference due to the roughly classified structure.
- citric acid, etidronic acid, phytic acid, and salts thereof, which are generally used, are preferable, citric acid, etidronic acid, and salts thereof are more preferable, and citric acid and salts thereof are most preferable.
- the skin cosmetic composition of the present invention contains the above-mentioned component (A), component (B) and component (C), and each component is composed of a plurality of components (for example, component (A) Is composed of hexyl glyceryl ether and cyclohexyl glyceryl ether), the total amount thereof is the amount of each component.
- component (A) Is composed of hexyl glyceryl ether and cyclohexyl glyceryl ether
- the component (A) is known to have an antibacterial effect, but when the component (B) and the component (C) are contained, the antibacterial effect is significantly improved over the component (A) alone. Therefore, the composition containing (A) component, (B) component, and (C) component works effectively as an antibacterial agent. Since the antibacterial agent is less irritating to the skin and excellent in the feeling of use, it can be said that it is an unprecedented antibacterial agent and can be used in a variety of applications. It is preferable to use it. If either one of the component (B) or the component (C) is not blended, the antibacterial effect cannot be expected to improve.
- the ratio of each component is not particularly specified, but because of its good antibacterial effect, component (B) is 1 to 30 parts by mass and component (C) is 0.05 to 10 parts by mass with respect to 1 part by mass of component (A).
- component (B) is more preferably 2 to 20 parts by mass and the component (C) is more preferably 0.1 to 5 parts by mass with respect to 1 part by mass of the component (A).
- the said compounding ratio is also the compounding ratio of each component in the antibacterial agent for skin cosmetics of this invention, and the compounding ratio of each component in the method of enhancing the antibacterial effect of the (A) component in skin cosmetics. Applied.
- the amount of the components (A) to (C) in the skin cosmetic composition of the present invention is not particularly defined, but the component (A) is 0.01 to 0.01% with respect to the total amount of the skin cosmetic composition.
- the blending is preferably 3% by mass, more preferably 0.1 to 2% by mass. When the amount is less than 0.01% by mass, a high antibacterial effect may not be obtained. When the amount exceeds 3% by mass, the skin irritation may be increased, or the effect corresponding to the additive may not be obtained.
- about the compounding quantity of (B) component and (C) component it is preferable to mix
- the components (A) to (C) may be added for each component, or (A) to (C) in advance. You may add in the form of the composition which mixed the component.
- the antibacterial agent for skin cosmetics of the present invention is in the form of a mixture as described above, in addition to the components (A) to (C), additives such as solvents such as water and alcohol, and surfactants It may be a composition in a state involving. In this case, since the handling is easy, it is preferable to adjust the solid content of the antibacterial agent for skin cosmetics to 30 to 90% by mass, and to adjust the solid content to 40 to 70% by mass. It is preferable. In addition, it is preferable to mix
- the performance of the cosmetic composition for skin of the present invention may vary depending on the type of component (A).
- component (A) is hexyl glyceryl ether
- the antibacterial effect tends to be higher than that of cyclohexyl glyceryl ether.
- component (A) is cyclohexyl glyceryl ether
- irritation to human skin tends to be weaker than that of hexyl glyceryl ether.
- A About the kind and compounding quantity of a component, what is necessary is just to select suitably according to the kind of cosmetics, and the effect to improve.
- the skin cosmetic composition of the present invention in addition to the above essential components, other components used in cosmetics, for example, powder components, liquid fats and oils, solid fats and oils, within a range not inhibiting the effects of the present invention, Wax, hydrocarbon, higher fatty acid, higher alcohol, ester, silicone, anionic surfactant, cationic surfactant, amphoteric surfactant, nonionic surfactant, moisturizer, water-soluble polymer, sequestering agent, lower 1 type or 2 or more types, such as alcohol, a polyhydric alcohol (except (B) component of this invention), sugar, an amino acid, an organic amine, a polymer emulsion, a pH adjuster, a skin nutrient, a vitamin, antioxidant, etc. It can mix
- POE represents “polyoxyethylene”
- POP” represents “polyoxypropylene”.
- the powder component examples include inorganic powders (for example, talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, saucite, biotite, permiculite, magnesium carbonate, calcium carbonate, silicic acid.
- inorganic powders for example, talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, saucite, biotite, permiculite, magnesium carbonate, calcium carbonate, silicic acid.
- Red No. 104 Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3 and Blue No. 1
- natural pigments for example, chlorophyll, ⁇ -carotene, etc.
- liquid oils examples include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern castor oil, castor oil, linseed oil , Safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin and the like.
- the solid fat include cacao butter, coconut oil, hardened coconut oil, palm oil, palm kernel oil, owl kernel oil, hardened oil, owl, and hardened castor oil.
- wax examples include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, Examples include jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.
- hydrocarbon oil examples include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and the like.
- higher fatty acids examples include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tall oil fatty acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) etc. are mentioned.
- higher alcohols examples include linear alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol); branched chain alcohols (eg, monostearyl glycerin ether (batyl alcohol) ), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyl decanol, isostearyl alcohol, octyldodecanol, etc.).
- linear alcohols eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol
- branched chain alcohols eg, monostearyl glycerin ether (batyl alcohol)
- 2-decyltetradecinol lanolin alcohol
- cholesterol phytosterol
- hexyl decanol isosteary
- ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, lactic acid Myristyl, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, Diisostearyl malate, glycerin di-2-heptylundecanoate, tri-2-ethylhexanoic
- silicone oil examples include linear polysiloxanes (for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxanes (for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexyl).
- silicone resins that form a three-dimensional network structure various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.) It is done.
- Anionic surfactants include, for example, fatty acid soaps (eg, sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (eg, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (eg, POE-lauryl sulfate triethanolamine, POE-sodium lauryl sulfate, etc.); N-acyl sarcosine acid (eg, sodium lauroyl sarcosine, etc.); higher fatty acid amide sulfonate (eg, sodium N-myristoyl-N-methyl taurate, palm Oil fatty acid methyl taurine sodium, lauryl methyl taurine sodium, etc .; phosphoric acid ester salts (POE-oleyl ether sodium phosphate, POE-stearyl ether phosphoric acid, etc.); sulfosuccinate (eg, , Sodium di
- Examples of the cationic surfactant include alkyltrimethylammonium salts (eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (eg, cetylpyridinium chloride, etc.); distearyldimethylammonium dialkyldimethylammonium chloride; Poly (N, N′-dimethyl-3,5-methylenepiperidinium chloride); alkyl quaternary ammonium salt; alkyldimethylbenzylammonium salt; alkylisoquinolinium salt; dialkyl morpholinium salt; POE-alkylamine; Examples include alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride and the like.
- alkyltrimethylammonium salts eg, stearyltrimethylammonium chloride, lauryltrimethyl
- amphoteric surfactants examples include imidazoline-based amphoteric surfactants (eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide). Side-1-carboxyethyloxy disodium salt, etc.); betaine surfactants (for example, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amide betaine) , Sulfobetaine, etc.).
- imidazoline-based amphoteric surfactants eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide).
- Nonionic surfactants include, for example, sorbitan fatty acid esters (for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate).
- sorbitan fatty acid esters for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate.
- Glycerol penta-2-ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl diglycerol sorbitan, etc.
- glycerin polyglycerin fatty acids eg mono cottonseed oil fatty acid glycerin, monoerucic acid glycerin, sesquioleate glycerin, glyceryl monostearate) , ⁇ , ⁇ '-oleic acid pyroglutamate glycerin, monostearate glycerin malate, etc.
- propylene glycol fatty acid esters eg monos Hydrogenated castor oil derivative; glycerin alkyl ether; POE-sorbitan fatty acid esters (for example, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraole) POE
- moisturizing agent examples include polyethylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salt, dl-pyrrolidone carboxyl
- moisturizing agent examples include acid salts, short-chain soluble collagen, diglycerin (EO) PO adducts, Izayoi rose extract, yarrow extract, and merirot extract.
- natural water-soluble polymers include plant-based polymers (for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, caraya gum, carrageenan, pectin, agar, quince seed (malmello), alge colloid (guckweed extract), starch (Rice, corn, potato, wheat), glycyrrhizic acid); microbial polymer (eg, xanthan gum, dextran, succinoglucan, bulllan, gellan gum); animal polymer (eg, collagen, casein, albumin, gelatin, etc.) ) And the like.
- plant-based polymers for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, caraya gum, carrageenan, pectin, agar, quince seed (malmello), alge colloid (guckweed extract), starch (Rice, corn, potato, wheat), glycyrrhizic acid);
- water-soluble polymers include starch polymers (eg, carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose polymers (methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropyl) Cellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, etc.); alginic acid polymers (eg, sodium alginate, propylene glycol alginate, etc.); vinyl polymers (eg, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone) , Carboxyvinyl polymer, etc.); polyoxyethylene polymer (eg, polyethylene glycol) Cole 20,000, 40,000, 60,000 polyoxyethylene polyoxypropylene copolymer, etc.); acrylic polymer (for example, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethyleneimine; c
- Examples of the sequestering agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate.
- Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.
- polyhydric alcohols examples include trivalent alcohols (eg, glycerin, trimethylolpropane, etc.); tetravalent alcohols (eg, pentaerythritol, such as 1,2,5,6-hexanetetraol); pentavalent alcohols (For example, xylitol); hexavalent alcohol (for example, sorbitol, mannitol, etc.); polyhydric alcohol polymer (for example, diethylene glycol, triethylene glycol, dipropylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, Triglycerin, tetraglycerin, polyglycerin, etc.); divalent alcohol alkyl ethers (for example, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glyco) Monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether,
- Monosaccharides include, for example, tricarbon sugars (eg, D-glyceryl aldehyde, dihydroxyacetone, etc.); tetracarbon sugars (eg, D-erythrose, D-erythrulose, D-treose, erythritol, etc.); pentose sugars (eg, L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, etc .; hexose (eg, D-glucose, D-talose, D) -Bucicose, D-galactose, D-fructose, L-galactose, L-mannose, D-tagatose, etc.); pentose sugar (eg, aldheptose, heproose, etc.); octo
- oligosaccharide examples include sucrose, umbelliferose, lactose, planteose, isolicnose, ⁇ , ⁇ -trehalose, raffinose, lycnose, umbilicin, stachyose verbus course and the like.
- polysaccharide examples include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran, kerato sulfate. , Locust bingham, succinoglucan, caronic acid and the like.
- amino acids examples include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like.
- amino acid derivatives include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl ⁇ -alanine sodium, glutathione, pyrrolidone carboxylic acid and the like.
- organic amines examples include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol. Is mentioned.
- Examples of the polymer emulsion include an acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin liquid, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and a natural rubber latex.
- Examples of the pH adjusting agent include buffers such as lactic acid-sodium lactate and succinic acid-sodium succinate.
- vitamins examples include vitamin A, B1, B2, B6, C, E and derivatives thereof, pantothenic acid and derivatives thereof, biotin and the like.
- antioxidant examples include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.
- anti-inflammatory agents eg, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.
- Products e.g., buckwheat, auren, shikon, peonies, birch, birch, sage, loquat, carrot, aloe, mallow, iris, grape, yokoinin, loofah, lily, saffron, nematode, ginger, hypericum, onionis, garlic, capsicum , Chimpi, toki, seaweed, etc.
- activator eg, royal jelly, photosensitizer, cholesterol derivative, etc.
- blood circulation promoter eg, nicotinic acid benzyl ester, nicotinic acid ⁇ -butoxyethyl ester, capsaicin, gingerone
- Cantharide egly
- the cosmetic composition for skin of the present invention may be used in any cosmetic composition as long as it is applied to human skin, for example, cream, facial cleansing cream, facial cleansing foam, cleansing cream, cleansing milk, cleansing lotion, Examples include massage creams, moisture creams, sunscreen creams, hand creams, lipsticks, liquid foundations, lotions, lotions, and emulsions.
- test lotion and a test cream were obtained from the lotion (formulation 1) and the cream (formulation 2) according to the following formula and the formulations shown in Tables 1 and 2.
- a “skin irritation test” was carried out using the obtained test lotion and test cream.
- the “preservation test” was performed.
- the five strains used for the evaluation are as follows.
- Formulation 1 lotion
- Polyethylene glycol weight average molecular weight 1500
- Glycerin 1.0%
- PEG-240 / decyltetradeces-20 / HDI 1.5%
- Xanthan gum 1.0%
- Sodium hydroxide appropriate amount (adjusted to pH 6.0) (A), (B), (C) component, etc. The amount of water shown in the table The remainder
- A-1 Hexyl glyceryl ether
- A-2 cyclohexyl glyceryl ether
- A-3 2-ethylhexyl glyceryl ether
- A-4 pentyl glyceryl ether
- B-1 1,2-propanediol
- B-2 tripropylene glycol
- B-3 Polypropylene glycol (weight average molecular weight 400)
- C-1 Citric acid
- C-2 Lactic acid
- C-3 Hydroxyethylethylenediamine triacetic acid
- C-4 Hydroxyethyliminodiacetic acid
- C-5 Dihydroxyethylglycine
- C-6 Gluconic acid
- C-7 Gluconolactone
- C -8 Phytic acid
- C-9 Penteto acid
- C-10 Etidronic acid
- C-11 Tartaric acid
- a skin irritation test and an antiseptic test were performed using the lotion and cream prepared by the above formulation.
- the test method is as follows. ⁇ Skin irritation test> After washing the face of 20 female monitors, the test cosmetic lotion was applied to the face, and the feeling of use was evaluated according to the following criteria. Scores were averaged and ranked according to the following criteria. The results are shown in Tables 3 and 4.
- ⁇ Preservation test> To the lotion and cream of the obtained test cosmetics, add the following three bacteria and two fungi to the test lotion and cream so that the number of bacteria is 10 6 cfu / g, After mixing until uniform, the “preservation test” was performed.
- the five strains used for the evaluation are as follows. (Bacteria) Escherichia coli ATCC 8739 Pseudomonas aeruginosa NBRC13275 Staphylococcus aureus ATCC 6538 (Fungi) Candida Albicans ATCC 10231 Aspergillus brasiliensis ATCC 16404
- the skin lotion and cream to which bacteria were added were operated according to the preservation efficacy test method listed in the Japanese Pharmacopoeia. Specifically, the skin lotion and cream to which bacteria were added were stored in a thermostatic bath at 25 ° C., the change in the number of bacteria after 2 weeks and 4 weeks was examined, and the antiseptic effect was determined according to the following evaluation criteria. . The results are shown in Tables 3 and 4.
- Bacteria The number of bacteria after 2 weeks is less than 0.1% of the number of bacteria at the time of addition (10 6 cfu / g), the number of bacteria after 4 weeks is the same as the number after 2 weeks
- Fungus the number of bacteria after 2 weeks Less than the number of bacteria at the time of addition (10 6 cfu / g)
- the number of bacteria after 4 weeks is the same as after 2 weeks Symbols in the table +: Does not meet the criteria-: Meets the criteria
- Example 1 is the lotion and cream which added the mixing
- the comparative example 1 was a comparative mixing
- 1 is a lotion and cream to which 1 is added.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
従って、本発明が解決しようとする課題は、人体に対する安全性が高く、且つ抗菌効果の高い皮膚用化粧料組成物、皮膚用化粧料用抗菌剤及びジオール化合物が有する抗菌効果の増強方法を提供することにある。
固体油脂としては、例えば、カカオ脂、ヤシ油、硬化ヤシ油、パーム油、パーム核油、モクロウ核油、硬化油、モクロウ、硬化ヒマシ油等が挙げられる。
炭化水素油としては、例えば、流動パラフィン、オゾケライト、スクワラン、プリスタン、パラフィン、セレシン、スクワレン、ワセリン、マイクロクリスタリンワックス等が挙げられる。
非イオン界面活性剤としては、例えば、ソルビタン脂肪酸エステル類(例えば、ソルビタンモノオレエート、ソルビタンモノイソステアレート、ソルビタンモノラウレート、ソルビタンモノパルミテート、ソルビタンモノステアレート、ソルビタンセスキオレエート、ソルビタントリオレエート、ペンタ-2-エチルヘキシル酸ジグリセロールソルビタン、テトラ-2-エチルヘキシル酸ジグリセロールソルビタン等);グリセリンポリグリセリン脂肪酸類(例えば、モノ綿実油脂肪酸グリセリン、モノエルカ酸グリセリン、セスキオレイン酸グリセリン、モノステアリン酸グリセリン、α,α'-オレイン酸ピログルタミン酸グリセリン、モノステアリン酸グリセリンリンゴ酸等);プロピレングリコール脂肪酸エステル類(例えば、モノステアリン酸プロピレングリコール等);硬化ヒマシ油誘導体;グリセリンアルキルエーテル;POE-ソルビタン脂肪酸エステル類(例えば、POE-ソルビタンモノオレエート、POE-ソルビタンモノステアレート、POE-ソルビタンモノオレート、POE-ソルビタンテトラオレエート等);POEソルビット脂肪酸エステル類(例えば、POE-ソルビットモノラウレート、POE-ソルビットモノオレエート、POE-ソルビットペンタオレエート、POE-ソルビットモノステアレート等);POE-グリセリン脂肪酸エステル類(例えば、POE-グリセリンモノステアレート、POE-グリセリンモノイソステアレート、POE-グリセリントリイソステアレート等のPOE-モノオレエート等);POE-脂肪酸エステル類(例えば、POE-ジステアレート、POE-モノジオレエート、ジステアリン酸エチレングリコール等);POE-アルキルエーテル類(例えば、POE-ラウリルエーテル、POE-オレイルエーテル、POE-ステアリルエーテル、POE-ベヘニルエーテル、POE-2-オクチルドデシルエーテル、POE-コレスタノールエーテル等);プルロニック型類(例えば、プルロニック等);POE・POP-アルキルエーテル類(例えば、POE・POP-セチルエーテル、POE・POP-2-デシルテトラデシルエーテル、POE・POP-モノブチルエーテル、POE・POP-水添ラノリン、POE・POP-グリセリンエーテル等);テトラPOE・テトラPOP-エチレンジアミン縮合物類(例えば、テトロニック等);POE-ヒマシ油硬化ヒマシ油誘導体(例えば、POE-ヒマシ油、POE-硬化ヒマシ油、POE-硬化ヒマシ油モノイソステアレート、POE-硬化ヒマシ油トリイソステアレート、POE-硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、POE-硬化ヒマシ油マレイン酸等);POE-ミツロウ・ラノリン誘導体(例えば、POE-ソルビットミツロウ等);アルカノールアミド(例えば、ヤシ油脂肪酸ジエタノールアミド、ラウリン酸モノエタノールアミド、脂肪酸イソプロパノールアミド等);POE-プロピレングリコール脂肪酸エステル;POE-アルキルアミン;POE-脂肪酸アミド;ショ糖脂肪酸エステル;アルキルエトキシジメチルアミンオキシド;トリオレイルリン酸等が挙げられる。
低級アルコールとしては、例えば、エタノール、プロパノール、イソプロパノール、イソブチルアルコール、t-ブチルアルコール等が挙げられる。
多糖としては、例えば、セルロース、クインスシード、コンドロイチン硫酸、デンプン、ガラクタン、デルマタン硫酸、グリコーゲン、アラビアガム、ヘパラン硫酸、ヒアルロン酸、トラガントガム、ケラタン硫酸、コンドロイチン、キサンタンガム、ムコイチン硫酸、グアガム、デキストラン、ケラト硫酸、ローカストビンガム、サクシノグルカン、カロニン酸等が挙げられる。
有機アミンとしては、例えば、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、モルホリン、トリイソプロパノールアミン、2-アミノ-2-メチル-1,3-プロパンジオール、2-アミノ-2-メチル-1-プロパノール等が挙げられる。
pH調製剤としては、例えば、乳酸-乳酸ナトリウム、コハク酸-コハク酸ナトリウム等の緩衝剤等が挙げられる。
酸化防止剤としては、例えば、トコフェロール類、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、没食子酸エステル類等が挙げられる。
<試験化粧料の作成>
化粧水(処方1)及びクリーム(処方2)を下記の処方及び表1、2の配合に従って試験化粧水及び試験クリームを得た。得られた試験化粧水及び試験クリームを使って「皮膚刺激性試験」を実施した。また、得られた試験化粧水及び試験クリームの菌数が106cfu/gとなるように、下記の細菌3種及び真菌2種をそれぞれの試験化粧水及び試験クリームに1種ずつ添加し、均一になるまで混合した後「防腐性試験」を実施した。なお評価に用いた5種類の菌株は以下の通りである。
Escherichia coli ATCC 8739
Pseudomonas aeruginosa NBRC13275
Staphylococcus aureus ATCC 6538
(真菌類)
Candida Albicans ATCC 10231
Aspergillus brasiliensis ATCC 16404
ポリエチレングリコール(重量平気分子量1500) 2.0%
グリセリン 1.0%
テトラオレイン酸ポリオキシエチレンソルビット(30EO) 1.5%
(PEG-240/デシルテトラデセス-20/HDI)コポリマー 0.8%
キサンタンガム 1.0%
水酸化ナトリウム 適量(pH 6.0に調整)
(A)、(B)、(C)成分等 表に示す配合量
水 残部
ジメチルポリシロキサン 8.0%
トリエチルヘキサノイン 10.0%
(アクリレーツ/アクリル酸アルキル(C10-30))クロスポリマー 0.2%
モノステアリン酸POE(20)ソルビタン 3.0%
グリセリン 2.0%
水酸化ナトリウム 適量(pH 6.0に調整)
(A)、(B)、(C)成分等 表に示す配合量
水 残部
<試験に使用した成分>
A-1:ヘキシルグリセリルエーテル
A-2:シクロヘキシルグリセリルエーテル
A-3:2-エチルヘキシルグリセリルエーテル
A-4:ペンチルグリセリルエーテル
B-1:1,2-プロパンジオール
B-2:トリプロピレングリコール
B-3:ポリプロピレングリコール(重量平均分子量400)
C-1:クエン酸
C-2:乳酸
C-3:ヒドロキシエチルエチレンジアミン三酢酸
C-4:ヒドロキシエチルイミノ二酢酸
C-5:ジヒドロキシエチルグリシン
C-6:グルコン酸
C-7:グルコノラクトン
C-8:フィチン酸
C-9:ペンテト酸
C-10:エチドロン酸
C-11:酒石酸
<皮膚刺激性試験>
女性モニター20人に、洗顔後、顔面に試験化粧料の化粧水を塗布して、下記の基準で、使用感を評価した。スコアの平均を取り、以下の基準でランク分けした。結果を表3、4に記す。
1:まったく刺激を感じない
2:微妙に何か刺激らしいものを感じる
3:軽い刺激感を感じる
4:強い刺激感を感じる
5:頬の上に置いておけないぐらいの刺激感を感じる
(ランク分け)
A:スコア平均が2.0未満
B:スコア平均が2.0以上3.0未満
C:スコア平均が3.0以上
得られた試験化粧料の化粧水及びクリームに、菌数が106cfu/gとなるように下記の細菌3種及び真菌2種をそれぞれの試験化粧水及び試験クリームに1種ずつ添加し、均一になるまで混合した後「防腐性試験」を実施した。なお評価に用いた5種類の菌株は以下の通りである。
(細菌類)
Escherichia coli ATCC 8739
Pseudomonas aeruginosa NBRC13275
Staphylococcus aureus ATCC 6538
(真菌類)
Candida Albicans ATCC 10231
Aspergillus brasiliensis ATCC 16404
細菌:2週間後の菌数が添加時の菌数(106cfu/g)の0.1%以下であり、4週間後の菌数が2週間後と同数以下
真菌:2週間後の菌数が添加時の菌数(106cfu/g)と同数以下であり、4週間後の菌数が2週間後と同数以下
表中の記号 +:基準を満たさない -:基準を満たす
以下に試験結果を記す。なお実施例及び比較例の数字は、上記の表1、2の配合の数字に対応しており、例えば、実施例1は配合1を添加した化粧水及びクリームであり、比較例1は比較配合1を添加した化粧水及びクリームである。
Claims (6)
- ヘキシルグリセリルエーテル及びシクロヘキシルグリセリルエーテルから選択される1種又は2種である(A)成分、1,2-プロパンジオール及び1,3-プロパンジオールから選択される1種又は2種である(B)成分、並びにクエン酸、乳酸、ヒドロキシエチルエチレンジアミン三酢酸、ヒドロキシエチルイミノ二酢酸、ジヒドロキシエチルグリシン、グルコン酸、フィチン酸、ペンテト酸、エチドロン酸、酒石酸及びこれらの塩、及びグルコノラクトンからなる群から選択される1種又は2種以上である(C)成分を含有する、皮膚用化粧料組成物。
- (A)成分1質量部に対して、(B)成分が1~30質量部、(C)成分が0.05~10質量部である、請求項1に記載の皮膚用化粧料組成物。
- 皮膚用化粧料組成物全量に対して、(A)成分を0.01~3質量%含有する、請求項1又は2に記載の皮膚用化粧料組成物。
- ヘキシルグリセリルエーテル及びシクロヘキシルグリセリルエーテルから選択される1種又は2種である成分(A)成分、1,2-プロパンジオール及び1,3-プロパンジオールから選択される1種又は2種である(B)成分、並びにクエン酸、乳酸、ヒドロキシエチルエチレンジアミン三酢酸、ヒドロキシエチルイミノ二酢酸、ジヒドロキシエチルグリシン、グルコン酸、フィチン酸、ペンテト酸、エチドロン酸、酒石酸及びこれらの塩、及びグルコノラクトンからなる群から選択される1種又は2種以上である(C)成分を含有する、皮膚用化粧料用抗菌剤。
- (A)成分1質量部に対して、(B)成分が1~30質量部、(C)成分が0.05~10質量部である、請求項4に記載の皮膚用化粧料用抗菌剤。
- ヘキシルグリセリルエーテル及びシクロヘキシルグリセリルエーテルから選択される1種又は2種である(A)成分、1,2-プロパンジオール及び1,3-プロパンジオールから選択される1種又は2種である(B)成分、並びにクエン酸、乳酸、ヒドロキシエチルエチレンジアミン三酢酸、ヒドロキシエチルイミノ二酢酸、ジヒドロキシエチルグリシン、グルコン酸、フィチン酸、ペンテト酸、エチドロン酸、酒石酸及びこれらの塩、並びにグルコノラクトンからなる群から選択される1種又は2種以上である(C)成分を皮膚用化粧料に添加することを含む、前記皮膚用化粧料における(A)成分の抗菌効果を増強する方法。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016503949A JP6557651B2 (ja) | 2014-02-24 | 2014-12-16 | 皮膚用化粧料組成物、皮膚用化粧料用抗菌剤及びジオール化合物が有する抗菌効果の増強方法 |
EP14883082.1A EP3111918B1 (en) | 2014-02-24 | 2014-12-16 | Skin cosmetic composition, antibacterial agent for skin cosmetic, and method for enhancing antibacterial effect of diol compound |
CN201480076260.5A CN106029048A (zh) | 2014-02-24 | 2014-12-16 | 皮肤用化妆料组合物、皮肤用化妆料用抗菌剂以及增强二醇化合物所具有的抗菌效果的方法 |
KR1020167023594A KR102280926B1 (ko) | 2014-02-24 | 2014-12-16 | 피부용 화장료 조성물, 피부용 화장료용 항균제 및 디올 화합물이 갖는 항균효과의 증강방법 |
US15/119,031 US10137069B2 (en) | 2014-02-24 | 2014-12-16 | Skin cosmetic composition, antibacterial agent for skin cosmetic, and method for enhancing antibacterial effect of diol compound |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014-032974 | 2014-02-24 | ||
JP2014032974 | 2014-02-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2015125392A1 true WO2015125392A1 (ja) | 2015-08-27 |
Family
ID=53877921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2014/083201 WO2015125392A1 (ja) | 2014-02-24 | 2014-12-16 | 皮膚用化粧料組成物、皮膚用化粧料用抗菌剤及びジオール化合物が有する抗菌効果の増強方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US10137069B2 (ja) |
EP (1) | EP3111918B1 (ja) |
JP (1) | JP6557651B2 (ja) |
KR (1) | KR102280926B1 (ja) |
CN (1) | CN106029048A (ja) |
WO (1) | WO2015125392A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017199921A1 (ja) * | 2016-05-20 | 2017-11-23 | 株式会社Adeka | 抗菌性組成物、それを含む化粧料組成物及び肌用シート状製品 |
WO2018142917A1 (ja) * | 2017-02-03 | 2018-08-09 | 株式会社Adeka | 化粧料の保存安定性を向上させる方法 |
WO2019073874A1 (ja) * | 2017-10-11 | 2019-04-18 | 株式会社Adeka | 抗菌性組成物及び該抗菌性組成物を含む化粧料 |
JP2020023478A (ja) * | 2018-07-31 | 2020-02-13 | 株式会社Adeka | 化粧料用乳化組成物 |
WO2020066893A1 (ja) * | 2018-09-25 | 2020-04-02 | 株式会社Adeka | グリセリルエーテル含有組成物の製造方法およびグリセリルエーテル含有組成物 |
RU2731917C1 (ru) * | 2016-11-28 | 2020-09-09 | Пола Кемикал Индастриз, Инк. | Средство для устранения морщин |
JP2022031761A (ja) * | 2017-02-03 | 2022-02-22 | 株式会社Adeka | 難水溶性成分の溶解性を向上させる方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3763353B1 (en) * | 2018-03-08 | 2024-01-24 | Adeka Corporation | Method for improving water solubility of sparingly-soluble component |
EP3735958A1 (en) * | 2019-05-10 | 2020-11-11 | DSM IP Assets B.V. | Topical compositions with preservation system |
KR20220006589A (ko) * | 2019-05-10 | 2022-01-17 | 디에스엠 아이피 어셋츠 비.브이. | 국소 조성물 |
IT201900006884A1 (it) * | 2019-05-16 | 2020-11-16 | Areaderma S R L | Prodotto topico preferibilmente di derivazione naturale |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000191509A (ja) * | 1998-12-25 | 2000-07-11 | Kao Corp | 皮膚洗浄剤組成物 |
JP2004307484A (ja) * | 2003-03-24 | 2004-11-04 | Mandom Corp | 防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品 |
JP2005213174A (ja) * | 2004-01-29 | 2005-08-11 | Mandom Corp | 防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品 |
JP2006273719A (ja) * | 2005-03-28 | 2006-10-12 | Adeka Corp | 抗菌剤組成物 |
JP2008266332A (ja) * | 2007-04-16 | 2008-11-06 | L'air Liquide Sante Internatl | グリセロールエーテル/ポリオール混合物に基づいた組成物 |
JP2011057647A (ja) * | 2009-09-14 | 2011-03-24 | Adeka Corp | 化粧料 |
JP2011173808A (ja) * | 2010-02-23 | 2011-09-08 | Adeka Corp | 化粧料 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3993163B2 (ja) | 2003-12-12 | 2007-10-17 | 花王株式会社 | 抗菌剤及び抗菌液体洗浄剤組成物 |
JP5025997B2 (ja) | 2005-06-08 | 2012-09-12 | 株式会社Adeka | 抗菌剤 |
JP5030422B2 (ja) | 2005-12-14 | 2012-09-19 | 株式会社Adeka | 抗菌剤及びこれを含有する抗菌性組成物 |
DE602007009841D1 (de) * | 2006-07-21 | 2010-11-25 | Kao Corp | Reinigungsmittelzusammensetzung für harte oberflächen |
KR101295789B1 (ko) * | 2007-11-14 | 2013-08-12 | 오엠피, 인코포레이티드 | 피부 치료용 조성물 |
FR2991176B1 (fr) * | 2012-06-01 | 2014-12-19 | Galderma Res & Dev | Compositions topiques, contenant un retinoide solubilise, de type gel hydroglycolique |
EP2807925A1 (en) | 2013-05-26 | 2014-12-03 | Symrise AG | Antimicrobial compositions |
-
2014
- 2014-12-16 WO PCT/JP2014/083201 patent/WO2015125392A1/ja active Application Filing
- 2014-12-16 CN CN201480076260.5A patent/CN106029048A/zh active Pending
- 2014-12-16 JP JP2016503949A patent/JP6557651B2/ja active Active
- 2014-12-16 KR KR1020167023594A patent/KR102280926B1/ko active IP Right Grant
- 2014-12-16 US US15/119,031 patent/US10137069B2/en active Active
- 2014-12-16 EP EP14883082.1A patent/EP3111918B1/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000191509A (ja) * | 1998-12-25 | 2000-07-11 | Kao Corp | 皮膚洗浄剤組成物 |
JP2004307484A (ja) * | 2003-03-24 | 2004-11-04 | Mandom Corp | 防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品 |
JP2005213174A (ja) * | 2004-01-29 | 2005-08-11 | Mandom Corp | 防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品 |
JP2006273719A (ja) * | 2005-03-28 | 2006-10-12 | Adeka Corp | 抗菌剤組成物 |
JP2008266332A (ja) * | 2007-04-16 | 2008-11-06 | L'air Liquide Sante Internatl | グリセロールエーテル/ポリオール混合物に基づいた組成物 |
JP2011057647A (ja) * | 2009-09-14 | 2011-03-24 | Adeka Corp | 化粧料 |
JP2011173808A (ja) * | 2010-02-23 | 2011-09-08 | Adeka Corp | 化粧料 |
Non-Patent Citations (1)
Title |
---|
See also references of EP3111918A4 * |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2017199921A1 (ja) * | 2016-05-20 | 2019-03-14 | 株式会社Adeka | 抗菌性組成物、それを含む化粧料組成物及び肌用シート状製品 |
WO2017199921A1 (ja) * | 2016-05-20 | 2017-11-23 | 株式会社Adeka | 抗菌性組成物、それを含む化粧料組成物及び肌用シート状製品 |
RU2731917C1 (ru) * | 2016-11-28 | 2020-09-09 | Пола Кемикал Индастриз, Инк. | Средство для устранения морщин |
WO2018142917A1 (ja) * | 2017-02-03 | 2018-08-09 | 株式会社Adeka | 化粧料の保存安定性を向上させる方法 |
JP7142138B2 (ja) | 2017-02-03 | 2022-09-26 | 株式会社Adeka | 難水溶性成分の溶解性を向上させる方法 |
JPWO2018142917A1 (ja) * | 2017-02-03 | 2019-11-21 | 株式会社Adeka | 化粧料の保存安定性を向上させる方法 |
JP7490336B2 (ja) | 2017-02-03 | 2024-05-27 | 株式会社Adeka | 化粧料の保存安定性を向上させる方法 |
JP2022031761A (ja) * | 2017-02-03 | 2022-02-22 | 株式会社Adeka | 難水溶性成分の溶解性を向上させる方法 |
WO2019073874A1 (ja) * | 2017-10-11 | 2019-04-18 | 株式会社Adeka | 抗菌性組成物及び該抗菌性組成物を含む化粧料 |
JPWO2019073874A1 (ja) * | 2017-10-11 | 2020-09-17 | 株式会社Adeka | 抗菌性組成物及び該抗菌性組成物を含む化粧料 |
EP3695827A4 (en) * | 2017-10-11 | 2021-07-21 | Adeka Corporation | ANTIBACTERIAL COMPOSITION AND COSMETIC PRODUCT INCLUDING THE SAID ANTIBACTERIAL COMPOSITION |
KR102591175B1 (ko) * | 2017-10-11 | 2023-10-18 | 가부시키가이샤 아데카 | 항균성 조성물 및 그 항균성 조성물을 포함하는 화장료 |
KR20200068683A (ko) * | 2017-10-11 | 2020-06-15 | 가부시키가이샤 아데카 | 항균성 조성물 및 그 항균성 조성물을 포함하는 화장료 |
US11260003B2 (en) | 2017-10-11 | 2022-03-01 | Adeka Corporation | Antimicrobial composition and cosmetic containing antimicrobial composition |
JP2020023478A (ja) * | 2018-07-31 | 2020-02-13 | 株式会社Adeka | 化粧料用乳化組成物 |
JP7448318B2 (ja) | 2018-07-31 | 2024-03-12 | 株式会社Adeka | 化粧料用乳化組成物 |
JP7362640B2 (ja) | 2018-09-25 | 2023-10-17 | 株式会社Adeka | グリセリルエーテル含有組成物の製造方法およびグリセリルエーテル含有組成物 |
JPWO2020066893A1 (ja) * | 2018-09-25 | 2021-08-30 | 株式会社Adeka | グリセリルエーテル含有組成物の製造方法およびグリセリルエーテル含有組成物 |
US11918668B2 (en) | 2018-09-25 | 2024-03-05 | Adeka Corporation | Method for producing glyceryl ether-containing composition, and glyceryl ether-containing composition |
WO2020066893A1 (ja) * | 2018-09-25 | 2020-04-02 | 株式会社Adeka | グリセリルエーテル含有組成物の製造方法およびグリセリルエーテル含有組成物 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2015125392A1 (ja) | 2017-03-30 |
EP3111918A4 (en) | 2017-08-02 |
KR20160115957A (ko) | 2016-10-06 |
US10137069B2 (en) | 2018-11-27 |
CN106029048A (zh) | 2016-10-12 |
JP6557651B2 (ja) | 2019-08-07 |
KR102280926B1 (ko) | 2021-07-22 |
EP3111918B1 (en) | 2019-08-14 |
EP3111918A1 (en) | 2017-01-04 |
US20160354291A1 (en) | 2016-12-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6557651B2 (ja) | 皮膚用化粧料組成物、皮膚用化粧料用抗菌剤及びジオール化合物が有する抗菌効果の増強方法 | |
KR102402508B1 (ko) | 고형 분말 화장료 | |
JP5277011B2 (ja) | 水中油型乳化白濁皮膚化粧料 | |
JP6362243B2 (ja) | 化粧料用ゲル状組成物 | |
JP2015027953A (ja) | 皮膚用化粧料 | |
CN111212626B (zh) | 抗菌性组合物以及含有该抗菌性组合物的化妆料 | |
US11395486B2 (en) | Antibacterial and antifungal composition | |
JP2008088127A (ja) | ニキビ肌用皮膚外用組成物 | |
JP3673924B2 (ja) | 皮膚外用剤 | |
WO2017073758A1 (ja) | 組成物 | |
JP2004143104A (ja) | 皮膚外用剤 | |
JPWO2018088570A1 (ja) | 皮膚外用剤組成物 | |
JP2006249049A (ja) | 皮膚外用組成物 | |
JP4349883B2 (ja) | 皮膚外用組成物 | |
JP2010047506A (ja) | ゾル−ゲル可逆性組成物、増粘剤及び化粧料。 | |
JP4375609B2 (ja) | 皮膚外用剤 | |
JP7412975B2 (ja) | 抗菌性組成物、該抗菌性組成物を含む化粧料組成物、及びグリセリルエーテル組成物の抗菌性を向上させる方法 | |
JP2010155792A (ja) | 皮膚外用剤 | |
JP4301499B2 (ja) | 皮膚外用組成物 | |
JP2020002032A (ja) | 抗菌性組成物及び該抗菌性組成物を含む化粧料 | |
JP2006256966A (ja) | 皮膚外用組成物 | |
JP2004307386A (ja) | 皮膚外用組成物 | |
JP2006188448A (ja) | 皮膚外用剤 | |
JP2009143837A (ja) | シワ形成抑制剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 14883082 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2016503949 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 15119031 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 20167023594 Country of ref document: KR Kind code of ref document: A |
|
REEP | Request for entry into the european phase |
Ref document number: 2014883082 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2014883082 Country of ref document: EP |